@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu35990: (2016-07-31 )
MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEAIDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELMLAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDISHSAKRLAEYIQQPFV
Atome Classification :
(45 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.---.--......20.......-.30........40-..------------------------------.......50........60........70........80........90.------------.----......100.......110.......120.......-130.-.......140.......-150...-....----160.......170...--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
L
V
L
A
VHPHM---
E
--
T
S
V
V
N
K
A
W
A
E
E
L
S
KH-DN
I
T
V
R
D
L
Y
K
EY--
P
D
------------------------------
E
A
I
D
V
A
K
E
Q
Q
L
C
E
E
Y
D
R
I
V
F
Q
F
P
L
Y
WYSS
P
P
L
L
K
K
W
Q
D
L
V
L
T
Y
G
WAFGSE------------G----NALHG
K
E
L
M
L
A
VSTGSE
A
E
K
YQAGGANHY
S
I
S
E
L
L
K
-
P
-
F
Q
-
A
T
S
NLIGMKYL
P
P
Y
V
F
Y-GVNY
A
A
-
A
E
D
I
----
S
H
S
A
K
R
L
A
E
Y
I
QQPFV--
119
HHSearch
91.78
36%
-165
- C1 -
3L9W
2
KEFC_ECOLI (first)
A:
[237-406]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
L
I
I
Y
A
H
P
Y
P
---
H
--
H
S
H
A
N
K
R
M
L
E
Q
A
R
T
L
-
E
G
V
E
I
R
S
L
Y
Q
L
Y
--
P
D
------------------------------
F
N
I
D
I
A
A
E
Q
E
A
L
S
R
A
D
L
I
V
W
Q
H
P
M
Q
W
Y
S
I
P
P
L
L
K
L
W
I
D
K
V
F
S
H
G
W
A
Y
G
H
G
------------
G
----
T
A
L
H
G
K
H
L
L
W
A
V
T
T
G
G
G
E
S
H
F
E
I
G
A
H
--
P
G
F
D
V
L
S
Q
-
P
-
L
Q
-
A
T
A
I
Y
C
G
L
N
W
L
P
P
F
A
M
H
-
C
T
F
I
C
D
-
D
E
T
L
----
E
G
Q
A
R
H
Y
K
Q
R
L
L
E
-----
3
PsiBlast_PDB
90.76
38%
-170
- C1 -
3L9W
2
KEFC_ECOLI (first)
A:
[239-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
I
I
Y
A
H
P
Y
P
---
H
--
H
S
H
A
N
K
R
M
L
E
Q
A
R
T
L
-
E
G
V
E
I
R
S
L
Y
Q
L
Y
--
P
D
------------------------------
F
N
I
D
I
A
A
E
Q
E
A
L
S
R
A
D
L
I
V
W
Q
H
P
M
Q
W
Y
S
I
P
P
L
L
K
L
W
I
D
K
V
F
S
H
G
W
A
Y
G
H
G
------------
G
----
T
A
L
H
G
K
H
L
L
W
A
V
T
T
G
G
G
E
S
H
F
E
I
G
A
--
H
P
G
F
D
V
L
S
Q
-
P
-
L
Q
-
A
T
A
I
Y
C
G
L
N
W
L
P
P
F
A
M
H
-
C
T
F
I
C
D
-
D
E
T
L
E
G
Q
A
R
H
Y
K
Q
R
L
L
E
W
--------
22
PsiBlast_CBE
88.90
38%
-171
- C1 -
3L9W
2
KEFC_ECOLI
B:
[239-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
I
I
Y
A
H
P
Y
P
---
H
--
H
S
H
A
N
K
R
M
L
E
Q
A
R
T
L
-
E
G
V
E
I
R
S
L
Y
Q
L
Y
--
P
D
------------------------------
F
N
I
D
I
A
A
E
Q
E
A
L
S
R
A
D
L
I
V
W
Q
H
P
M
Q
W
Y
S
I
P
P
L
L
K
L
W
I
D
K
V
F
S
H
G
W
A
Y
G
H
G
------------
G
----
T
A
L
H
G
K
H
L
L
W
A
V
T
T
G
G
G
E
S
H
F
E
I
G
A
--
H
P
G
F
D
V
L
S
Q
-
P
-
L
Q
-
A
T
A
I
Y
C
G
L
N
W
L
P
P
F
A
M
H
-
C
T
F
I
C
D
-
D
E
T
L
E
G
Q
A
R
H
Y
K
Q
R
L
L
E
W
--------
21
PsiBlast_CBE
88.79
38%
-172
- C1 -
3L9X
2
KEFC_ECOLI
B:
[239-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
I
I
Y
A
H
P
Y
P
---
H
--
H
S
H
A
N
K
R
M
L
E
Q
A
R
T
L
-
E
G
V
E
I
R
S
L
Y
Q
L
Y
--
P
D
------------------------------
F
N
I
D
I
A
A
E
Q
E
A
L
S
R
A
D
L
I
V
W
Q
H
P
M
Q
W
Y
S
I
P
P
L
L
K
L
W
I
D
K
V
F
S
H
G
W
A
Y
G
H
G
------------
G
----
T
A
L
H
G
K
H
L
L
W
A
V
T
T
G
G
G
E
S
H
F
E
I
G
A
--
H
P
G
F
D
V
L
S
Q
-
P
-
L
Q
-
A
T
A
I
Y
C
G
L
N
W
L
P
P
F
A
M
H
-
C
T
F
I
C
D
-
D
E
T
L
EGQA
R
H
Y
K
Q
R
L
L
E
W
--------
4
PsiBlast_PDB
88.42
38%
-168
- C1 -
3L9X
2
KEFC_ECOLI (first)
A:
[239-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
I
I
Y
A
H
P
Y
P
---
H
--
H
S
H
A
N
K
R
M
L
E
Q
A
R
T
L
-
E
G
V
E
I
R
S
L
Y
Q
L
Y
--
P
D
------------------------------
F
N
I
D
I
A
A
E
Q
E
A
L
S
R
A
D
L
I
V
W
Q
H
P
M
Q
W
Y
S
I
P
P
L
L
K
L
W
I
D
K
V
F
S
H
G
W
A
Y
G
H
G
------------
G
----
T
A
L
H
G
K
H
L
L
W
A
V
T
T
G
G
G
E
S
H
F
E
I
G
A
--
H
P
G
F
D
V
L
S
Q
-
P
-
L
Q
-
A
T
A
I
Y
C
G
L
N
W
L
P
P
F
A
M
H
-
C
T
F
I
C
D
-
D
E
T
L
E
G
Q
A
R
H
Y
K
Q
R
L
L
E
W
--------
23
PsiBlast_CBE
87.31
38%
-171
- C1 -
3EYW
2
KEFC_ECOLI
B:
[239-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
I
I
Y
A
H
P
Y
P
---
H
--
H
S
H
A
N
K
R
M
L
E
Q
A
R
T
L
-
E
G
V
E
I
R
S
L
Y
Q
L
Y
--
P
D
------------------------------
F
N
I
D
I
A
A
E
Q
E
A
L
S
R
A
D
L
I
V
W
Q
H
P
M
Q
W
Y
S
I
P
P
L
L
K
L
W
I
D
K
V
F
S
H
G
W
A
Y
G
H
G
------------
G
----
T
A
L
H
G
K
H
L
L
W
A
V
T
T
G
G
G
E
S
H
F
E
I
G
A
--
H
P
G
F
D
V
L
S
Q
-
P
-
L
Q
-
A
T
A
I
Y
C
G
L
N
W
L
P
P
F
A
M
H
-
C
T
F
I
C
D
-
D
E
T
L
E
G
Q
A
R
H
Y
K
Q
R
L
L
E
W
--------
2
PsiBlast_PDB
86.25
38%
-169
- C1 -
3EYW
2
KEFC_ECOLI (first)
A:
[239-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
I
I
Y
A
H
P
Y
P
---
H
--
H
S
H
A
N
K
R
M
L
E
Q
A
R
T
L
-
E
G
V
E
I
R
S
L
Y
Q
L
Y
--
P
D
------------------------------
F
N
I
D
I
A
A
E
Q
E
A
L
S
R
A
D
L
I
V
W
Q
H
P
M
Q
W
Y
S
I
P
P
L
L
K
L
W
I
D
K
V
F
S
H
G
W
A
Y
G
H
G
------------
G
----
T
A
L
H
G
K
H
L
L
W
A
V
T
T
G
G
G
E
S
H
F
E
I
G
A
--
H
P
G
F
D
V
L
S
Q
-
P
-
L
Q
-
A
T
A
I
Y
C
G
L
N
W
L
P
P
F
A
M
H
-
C
T
F
I
C
D
-
D
E
T
L
E
G
Q
A
R
H
Y
K
Q
R
L
L
E
W
--------
111
HHSearch
78.80
43%
-37
- C1 -
3F2V
1
?
A:
[2-175]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
T
L
I
I
L
A
H
P
N
I
---
S
--
Q
S
T
V
H
K
H
W
S
D
A
V
R
Q
H
T
D
R
F
T
V
H
E
L
Y
A
V
Y
--
P
Q
------------------------------
G
K
I
D
V
A
A
E
Q
K
L
I
E
T
H
D
S
L
V
W
Q
F
P
I
Y
W
F
N
C
P
P
L
L
K
Q
W
L
D
E
V
L
T
Y
G
W
A
Y
G
S
K
------------
G
----
K
A
L
K
G
R
K
I
A
L
A
V
S
L
G
A
P
A
A
D
Y
R
A
D
G
A
V
G
C
S
V
A
E
V
L
R
-
P
-
F
E
-
L
T
A
K
Y
C
N
A
D
Y
R
P
P
F
T
F
H
-
T
-----S
E
A
A
R
----
Q
E
V
E
R
S
A
R
D
Y
L
-------
1
PsiBlast_PDB
78.59
44%
-37
- C1 -
3F2V
1
?
A:
[3-172]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
I
I
L
A
H
P
N
I
---
S
--
Q
S
T
V
H
K
H
W
S
D
A
V
R
Q
H
T
D
R
F
T
V
H
E
L
Y
A
V
Y
--
P
Q
------------------------------
G
K
I
D
V
A
A
E
Q
K
L
I
E
T
H
D
S
L
V
W
Q
F
P
I
Y
W
F
N
C
P
P
L
L
K
Q
W
L
D
E
V
L
T
Y
G
W
A
Y
G
S
K
------------
G
----
K
A
L
K
G
R
K
I
A
L
A
V
S
L
G
A
P
A
A
D
Y
R
A
D
G
A
V
G
C
S
V
A
E
V
L
R
-
P
-
F
E
-
L
T
A
K
Y
C
N
A
D
Y
R
P
P
F
T
F
H
T--
S
E
A
A
-
R
Q
E
V
----
E
R
S
A
R
-------------
115
HHSearch
76.87
39%
-90
- C1 -
3HA2
2
?
A:
[1-167]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
T
L
I
I
V
A
H
P
E
L
ARS
N
--
T
Q
P
F
F
K
A
A
I
E
N
F
S
----
N
V
T
W
H
P
L
V
A
-------------------------------------
D
F
N
V
E
Q
E
Q
S
L
L
L
Q
N
D
R
I
I
L
E
F
P
L
Y
W
Y
S
A
P
A
L
L
K
Q
W
M
D
T
V
M
T
T
K
F
A
T
G
H
-------------
Q
----
Y
A
L
E
G
K
E
L
G
I
V
V
S
T
G
D
N
G
N
A
F
Q
A
G
A
A
E
K
F
T
I
S
E
L
M
R
-
P
-
F
E
-
A
F
A
N
K
T
K
M
M
Y
L
P
I
L
A
V
H
-
Q
F
L
Y
L
E
-
P
D
A
Q
----
Q
R
L
L
V
A
Y
Q
Q
Y
A
T
N
V
----
5
PsiBlast_PDB
70.73
39%
-153
- C1 -
3HA2
2
?
A:
[2-138]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
L
I
I
V
A
H
P
E
L
---
A
--
R
S
N
T
Q
P
F
F
K
A
A
I
E
N
F
-
S
N
V
T
W
H
P
L
V
A
D
F
-------------------------------------
N
V
E
Q
E
Q
S
L
L
L
Q
N
D
R
I
I
L
E
F
P
L
Y
W
Y
S
A
P
A
L
L
K
Q
W
M
D
T
V
M
T
T
K
F
A
T
G
H
Q
-----------------
Y
A
L
E
G
K
E
L
G
I
V
V
S
T
G
D
N
G
N
A
F
Q
A
G
A
A
E
K
F
T
I
S
E
L
M
R
-
P
-
F
E
-
A
F
A
N
K
T
K
M
M
Y
L
P
---------------------------------------
101
Fugue
70.11
35%
-23
- C1 -
3EYW
4
KEFC_ECOLI (first)
B:
[5-411]
M
R
V
I
I
A
G
FG
R
F
G
Q
I
T
G
R
L
L
L
S
S
G
V
K
M
V
V
L
D
HDPDH
I
E
T
L
R
K
F
GMKVFYGDATR
M
D
L
L
E
S
A
GAAKAEVLINAIDD
P
Q
T
N
L
Q
L
T
E
M
V
K
E
HFPH
L
Q
I
I
A
R
A
RD
V
D
H
Y
I
R
L
R
Q
A
GVEKPERET
F
E
G
A
L
K
T
G
R
L
A
L
E
S
L
GLG
P
Y
E
A
R
E
R
A
D
V
F
R
R
F
N
I
Q
M
V
E
E
M
A
M
V
END
T
K
A
R
A
A
V
Y
K
R
T
S
A
M
I
L
I
I
Y
A
H
P
Y
P
---
H
--
H
S
H
A
N
K
R
M
L
E
Q
A
R
T
L
-
E
G
V
E
I
R
S
L
Y
Q
L
Y
--
P
D
------------------------------
F
N
I
D
I
A
A
E
Q
E
A
L
S
R
A
D
L
I
V
W
Q
H
P
M
Q
W
Y
S
I
P
P
L
L
K
L
W
I
D
K
V
F
S
H
G
W
A
Y
G
H
G
------------
G
----
T
A
L
H
G
K
H
L
L
W
A
V
T
T
G
G
G
E
S
H
F
E
I
G
A
H
P
G
--
F
D
V
L
S
Q
-
P
-
L
Q
-
A
T
A
I
Y
C
G
L
N
W
L
P
P
F
A
M
H
-
C
T
F
I
C
D
-
D
E
T
L
----
E
G
Q
A
R
H
Y
K
Q
R
L
L
E
W
Q
E
A
H
121
HHSearch
65.87
31%
-14
- C1 -
4GI5
6
?
A:
[23-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
V
L
L
I
Y
A
H
P
E
P
---
R
S
L
N
G
A
L
K
N
F
A
I
R
H
L
Q
Q
A
G
H
E
V
Q
V
S
D
L
Y
A
M
R
WK
A
G
YDADDSGAPPVGEFWRPT
L
D
S
K
Q
A
F
A
Q
GT-
Q
S
A
D
I
V
A
E
Q
E
K
L
L
W
A
D
T
V
I
F
Q
F
P
L
W
W
F
S
M
P
A
I
M
K
G
W
I
D
R
V
Y
A
W
G
F
A
Y
G
V
G
E
H
S
DRHWGDRYG
E
----
G
T
F
V
G
K
R
A
M
L
I
V
T
A
G
G
W
A
E
H
Y
S
P
R
G
I
N
-
G
P
I
D
D
I
L
F
-
P
I
Q
H
-
G
M
L
F
Y
P
G
F
E
V
L
P
P
L
V
F
Y
-
R
T
D
K
T
D
-
A
G
Q
F
----
A
D
Q
C
A
A
L
A
E
R
L
D
T
L
----
120
HHSearch
62.11
34%
6
- C1 -
4FGL
5
NQO2_HUMAN
A:
[6-217]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
L
I
V
Y
A
H
Q
E
P
---
K
S
F
N
G
S
L
K
N
V
A
V
D
E
L
S
R
Q
G
C
T
V
T
V
S
D
L
Y
A
M
N
FE
P
R
ATDKDITGTLSNPEVFN
Y
G
V
E
T
H
E
A
Y
K
Q
RS
L
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
GFYD--------
S
----
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
P
L
-
Q
H
-
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
R
----
K
G
M
V
A
A
W
S
Q
R
L
Q
T
I
----
28
PsiBlast_CBE
52.59
40%
-64
- C1 -
4XDG
8
NQO2_HUMAN
A:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
50
PsiBlast_CBE
52.45
40%
-60
- C1 -
4FGL
5
NQO2_HUMAN
C:
[84-202]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
17
PsiBlast_PDB
52.02
40%
-56
- C1 -
4QOD
6
NQO2_HUMAN
A:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
81
PsiBlast_CBE
51.93
40%
-62
- C1 -
3UXE
5
NQO2_HUMAN
A:
[81-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
35
PsiBlast_CBE
51.09
40%
-57
- C1 -
4QOG
5
NQO2_HUMAN
B:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
27
PsiBlast_CBE
51.02
40%
-59
- C1 -
4XDG
5
NQO2_HUMAN
B:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
29
PsiBlast_CBE
50.13
40%
-63
- C1 -
4QOJ
5
NQO2_HUMAN
B:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
37
PsiBlast_CBE
50.12
40%
-59
- C1 -
4QOE
4
NQO2_HUMAN
B:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
11
PsiBlast_PDB
50.01
40%
-57
- C1 -
3OVM
5
NQO2_HUMAN
A:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
33
PsiBlast_CBE
49.93
40%
-61
- C1 -
4QOH
5
NQO2_HUMAN
B:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
32
PsiBlast_CBE
49.40
40%
-61
- C1 -
4QOI
5
NQO2_HUMAN
A:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
38
PsiBlast_CBE
49.04
40%
-59
- C1 -
4QOD
5
NQO2_HUMAN
B:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
75
PsiBlast_CBE
48.48
40%
-52
- C1 -
4GR9
5
NQO2_HUMAN
A:
[81-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
62
PsiBlast_CBE
48.45
40%
-62
- C1 -
4ZVN
6
?
B:
[81-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
48
PsiBlast_CBE
48.20
40%
-57
- C1 -
1ZX1
5
NQO2_HUMAN
B:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
19
PsiBlast_PDB
47.94
40%
-59
- C1 -
4QOF
3
NQO2_HUMAN
A:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
13
PsiBlast_PDB
47.84
40%
-56
- C1 -
3OWX
5
NQO2_HUMAN
A:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
10
PsiBlast_PDB
47.71
40%
-63
- C1 -
3GAM
5
NQO2_HUMAN
A:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
55
PsiBlast_CBE
47.67
40%
-53
- C1 -
4FGJ
7
NQO2_HUMAN
B:
[84-202]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
85
PsiBlast_CBE
47.32
40%
-56
- C1 -
3NHY
5
NQO2_HUMAN
A:
[81-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
93
PsiBlast_CBE
47.09
40%
-54
- C1 -
3NHR
6
NQO2_HUMAN
A:
[81-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
91
PsiBlast_CBE
47.08
40%
-58
- C1 -
3NHS
5
NQO2_HUMAN
A:
[81-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
73
PsiBlast_CBE
46.98
40%
-53
- C1 -
4U7F
5
NQO2_HUMAN
A:
[81-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
71
PsiBlast_CBE
46.75
40%
-55
- C1 -
4U7G
5
NQO2_HUMAN
A:
[81-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
9
PsiBlast_PDB
46.64
40%
-61
- C1 -
3G5M
5
NQO2_HUMAN
A:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
87
PsiBlast_CBE
46.54
40%
-57
- C1 -
3NHW
5
NQO2_HUMAN
A:
[81-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
16
PsiBlast_PDB
46.45
40%
-61
- C1 -
3OX3
5
NQO2_HUMAN
A:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
89
PsiBlast_CBE
45.72
40%
-58
- C1 -
3NHU
5
NQO2_HUMAN
A:
[81-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
14
PsiBlast_PDB
45.59
40%
-61
- C1 -
3OX1
5
NQO2_HUMAN
A:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
97
PsiBlast_CBE
45.20
40%
-59
- C1 -
3NHL
5
NQO2_HUMAN
A:
[81-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------
15
PsiBlast_PDB
44.77
40%
-51
- C1 -
3OX2
5
NQO2_HUMAN
A:
[82-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
I
T
D
E
Q
K
K
V
R
E
A
D
L
V
I
F
Q
F
P
L
Y
W
F
S
V
P
A
I
L
K
G
W
M
D
R
V
L
C
Q
G
F
A
F
D
I
P
------------
G
FYDS
G
L
L
Q
G
K
L
A
L
L
S
V
T
T
G
G
T
A
E
M
Y
T
K
T
G
V
N
G
D
S
-
R
Y
F
L
W
-
P
-
L
Q
H
G
T
L
H
F
C
G
F
K
V
L
A
P
Q
I
S
F
-
A
P
E
I
A
S
-
E
E
E
-----------------------