@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MC5R_HUMAN: (2016-01-11 )
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110-.--.......120--------.........130.......140.......150.---......160.....------------------------..170---------------...--.--.....-----------------------180---------------------..----------------------.----------------------..-....190....----...200.......210.......220..-------------------------------------------------------------------------------------------------------------------------------------------------------.---------------....230.-----------------------------------------------------------------------------------------------------------------------------------------------------.----.----....240.......250.......260.......270.......280...--.--...290.......300.......310.......320...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNS
S
F
H
L
H
F
L
D
L
N
L
N
ATEGNLSGPNVKNKSSPCEDM
G
I
A
V
E
V
F
L
T
L
G
V
I
S
L
L
E
N
I
L
V
I
G
A
I
VKNKNLHS
P
M
Y
F
F
V
C
S
L
A
V
A
D
M
L
V
S
M
SSA
W
E
T
I
T
I
Y
L
LNN
K
H
L
V
I
A
D
A
F
V
--
R
--
H
I
D
N
V
F
D
S
----------
M
I
C
I
S
V
V
A
S
M
C
S
L
L
A
I
A
V
D
R
Y
V
T
I
F
Y
A
L
R
Y
H
H
I
---
M
TARRSGA
I
I
A
G
I
W
------------------------
A
F
C-----------------TGC--
G
--
I
V
F
I
L
-----------------------Y-----------------------SE----------------------S----------------------
T
Y
-
V
I
L
C
L
I
S
M
F
F
A
----
M
L
F
L
L
V
S
L
Y
I
H
M
F
L
L
A
R
T
H
V
K
R
I
AALPG-------------------------------------------------------------------------------------------------------------------------------------------------------A---------------S
S
A
R
Q
RTS-----------------------------------------------------------------------------------------------------------------------------------------------------M----Q----G
A
V
T
V
T
M
L
L
G
V
F
T
V
C
W
A
P
F
F
L
H
L
T
L
M
LSCPQ
N
L
Y
C
S
R
F
M
S
H
F
N
M
Y
L
I
L
I
M
--
C
--
N
S
V
M
D
P
L
I
Y
A
F
R
S
Q
E
M
R
K
T
F
K
E
I
I
C
CRG
F
R
I
A
CSFPRRD
25
HHSearch
94.97
30%
-176
- C1 -
3EML
13
ENLYS_BPT4
A:
[23-472]
-------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
-----
G
F
C
A
A
C
H
G
--
C
--
L
F
I
A
C
F
V
L
-------------
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
------------------------
V
L
S
-----------------
F
A
I
--
G
--
L
T
P
M
L
-----------------------
G
-----------------------
W
N
----------------------
N
CGQSQGCGEGQVACLFEDVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
----
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
-
A
---------------
Y
R
S
T
L
Q
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
V
----
H
----
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
--
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------
7
PsiBlast_PDB
91.98
28%
-179
- C1 -
3PWH
1
?
A:
[7-303]
------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
I
----------
S
T
G
F
C
--
A
A
C
H
G
C
L
F
I
A
C
----------
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
------------------------
V
L
S
F
A
I
G
L
T
PMLGWNNCGQP-
G
C
--
G
EG
Q
V
A
C
L
-----------------------
F
-----------------------
E
D
----------------------
V
----------------------
V
P
-
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
P
G
E
R
A
R
S
T
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
----
M
Y
L
A
I
V
L
--
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------
10
PsiBlast_PDB
91.72
28%
-184
- C1 -
3UZA
1
AA2AR_HUMAN
A:
[7-303]
------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
I
----------
S
T
G
F
C
--
A
A
C
H
G
C
L
F
I
A
C
----------
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
------------------------
V
L
S
F
A
I
G
L
T
PMLGWNNCGQP-
G
C
--
G
EG
Q
V
A
C
L
-----------------------
F
-----------------------
E
D
----------------------
V
----------------------
V
P
-
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
P
G
E
R
A
R
S
T
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
----
M
Y
L
A
I
V
L
--
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------
5
PsiBlast_PDB
91.42
28%
-188
- C1 -
3VG9
8
?
A:
[6-303]
-----------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
----------
S
T
G
F
C
--
A
A
C
H
G
C
L
F
I
A
C
----------
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
------------------------
V
L
S
F
A
I
G
L
TPMLGWNNCGQS
Q
G
C
--
G
EG
Q
V
A
C
L
-----------------------
F
-----------------------
E
D
----------------------
V
----------------------
V
P
-
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
P
G
E
R
A
R
S
T
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
----
M
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------
11
PsiBlast_PDB
90.60
28%
-182
- C1 -
3UZC
1
AA2AR_HUMAN
A:
[7-303]
------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
I
----------
S
T
G
F
C
--
A
A
C
H
G
C
L
F
I
A
C
----------
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
------------------------
V
L
S
F
A
I
G
L
T
PMLGWNNCGQP-
G
C
--
G
EG
Q
V
A
C
L
-----------------------
F
-----------------------
E
D
----------------------
V
----------------------
V
P
-
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
P
G
E
R
A
R
S
T
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
----
M
Y
L
A
I
V
L
--
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------
9
PsiBlast_PDB
90.56
28%
-178
- C1 -
3RFM
1
AA2AR_HUMAN
A:
[7-303]
------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
I
----------
S
T
G
F
C
--
A
A
C
H
G
C
L
F
I
A
C
----------
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
------------------------
V
L
S
F
A
I
G
L
T
PMLGWNNCGQP-
G
C
--
G
EG
Q
V
A
C
L
-----------------------
F
-----------------------
E
D
----------------------
V
----------------------
V
P
-
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
P
G
E
R
A
R
S
T
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
----
M
Y
L
A
I
V
L
--
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------
8
PsiBlast_PDB
90.43
28%
-180
- C1 -
3REY
1
AA2AR_HUMAN
A:
[7-303]
------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
I
----------
S
T
G
F
C
--
A
A
C
H
G
C
L
F
I
A
C
----------
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
------------------------
V
L
S
F
A
I
G
L
T
PMLGWNNCGQP-
G
C
--
G
EG
Q
V
A
C
L
-----------------------
F
-----------------------
E
D
----------------------
V
----------------------
V
P
-
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
P
G
E
R
A
R
S
T
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
----
M
Y
L
A
I
V
L
--
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------
6
PsiBlast_PDB
90.23
28%
-184
- C1 -
3VGA
1
AA2AR_HUMAN
A:
[6-303]
-----------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
----------
S
T
G
F
C
--
A
A
C
H
G
C
L
F
I
A
C
----------
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
------------------------
V
L
S
F
A
I
G
L
T
PMLGWNNCGQS
Q
G
C
--
G
EG
Q
V
A
C
L
-----------------------
F
-----------------------
E
D
----------------------
V
----------------------
V
P
-
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
P
G
E
R
A
R
S
T
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
----
M
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------
1
PsiBlast_PDB
90.23
28%
-207
- C1 -
2YDO
3
?
A:
[6-303]
-----------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
------------------
V
L
A
I
P
F
A
--
I
--
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQPK
E
G
K
A
H
S
-----------------
Q
G
C
GE
G
--
Q
V
A
C
L
-----------------------
F
-----------------------
E
D
----------------------
V
----------------------
V
P
-
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
----
M
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
4
PsiBlast_PDB
89.62
28%
-199
- C1 -
4UHR
1
AA2AR_HUMAN
A:
[6-303]
-----------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
------------------
V
L
A
I
P
F
A
--
I
--
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQPKEGK
A
--------------------
G
C
GE
G
--
Q
V
A
C
L
-----------------------
F
-----------------------
E
D
----------------------
V
----------------------
V
P
-
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
P
G
E
R
A
R
S
T
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
A
P
L
W
L
----
M
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
2
PsiBlast_PDB
89.46
28%
-203
- C1 -
2YDV
6
?
A:
[3-303]
--------------------------------
I
M
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
------------------
V
L
A
I
P
F
A
--
I
--
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQPK
E
G
K
A
H
S
-----------------
Q
G
C
GE
G
--
Q
V
A
C
L
-----------------------
F
-----------------------
E
D
----------------------
V
----------------------
V
P
-
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
----
M
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
26
HHSearch
88.94
25%
-164
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[45-477]
----------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
---
M
K
M
W
T
F
G
N
F
W
--
C
--
E
F
W
T
S
I
D
V
----------
L
---
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
------------------------
I
V
S
-----------------
G
L
T
--
S
--
F
L
P
I
Q
-----------------------
M
H----------------------
W
Y
RATH
Q
E
A
I
N
C
Y
A
EETCCDFFTN
Q
----------------------
A
Y
-
A
I
A
S
S
I
V
S
F
Y
V
----
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
---------------
A
Y
K
F
C
L
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
----
K
----
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
----
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
--
V
--
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------
3
PsiBlast_PDB
88.93
28%
-207
- C1 -
4UG2
3
?
A:
[6-303]
-----------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
------------------
V
L
A
I
P
F
A
--
I
--
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
TPMLGWNNCGQPK
E
G
K
A
H
S
-----------------
Q
G
C
GE
G
--
Q
V
A
C
L
-----------------------
F
-----------------------
E
D
----------------------
V
----------------------
V
P
-
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
S
T
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
----
M
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------
28
HHSearch
86.33
23%
-163
- C1 -
3PBL
2
DRD3_HUMAN (first)
A:
[43-472]
----------------------------------------
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
--
G
G
V
W
N
F
S
R
I
C
--
C
--
D
V
F
V
T
L
D
V
----------
M
---
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
------------------------
V
L
A
-----------------
F
A
V
--
S
--
C
P
L
L
F
-----------------------
G
-----------------------
F
N
----------------------
T
TGDPTVCSISN
P
----------
D
F
-
V
I
Y
S
S
V
V
S
F
Y
L
----
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW
D
---------------
A
Y
G
V
P
L
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
----
K
----
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
---
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
--
V
--
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-------------
45
Fugue
85.40
23%
-180
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
--------
V
V
P
F
G
A
A
H
I
L
M
K
M
W
T
FG
N
--
F
W
C
E
F
W
T
S
----------
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
------------------------
I
V
S
-----------------
G
L
T
--
S
--
F
L
P
I
Q
-----------------------
M
HWYRATH
Q
E
A
I
N
C
Y
A
EETCCDFF
T
N
----------------------
Q
----------------------
A
Y
-
A
I
A
S
S
I
V
S
F
Y
V
----
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------
D
---------------
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
----
K
----
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
----
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
--
V
--
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------
32
HHSearch
85.31
27%
-164
- C1 -
3V2Y
1
ENLYS_BPT4
A:
[68-495]
----------------------------------------
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
T
A
N
L
L
L
S
G
A
----
T
T
Y
K
L
T
P
A
Q
--
W
--
F
L
R
E
G
S
M
F
-------------
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
------------------------
V
I
S
-----------------
L
I
L
--
G
--
G
L
P
I
M
-----------------------
G
-----------------------
W
N
----------------------
C
ISALSSCSTVLPLYH-------
K
H
-
Y
I
L
F
C
T
T
V
F
T
L
----
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
---------------
Y
A
S
R
S
S
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------
V
----
A
----
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
V
K
T
--
C
D
I
L
F
R
A
E
Y
F
L
V
L
A
V
--
L
--
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
-----------
24
HHSearch
83.46
23%
-160
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[13-443]
----------------------------------------
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
---
M
S
K
W
S
L
G
R
P
L
--
C
--
L
F
W
L
S
M
D
Y
-------------
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
------------------------
F
L
S
-----------------
F
L
W
--
V
--
I
P
I
L
G
-----------------------
W
-----------------------
N
H
-----------------------RREDKCETDFYDV
T
--------
W
F
-
K
V
M
T
A
I
I
N
F
Y
L
----
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
-----------------
N
R
A
K
R
V
I
T
T
F
R
TGTWD
A
Y
L
H
M
N
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
----
K
----
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
C
----
N
E
H
L
H
M
F
T
I
W
L
G
Y
--
I
--
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-------------
12
PsiBlast_PDB
83.08
25%
-198
- C1 -
2VT4
8
ADRB1_MELGA
A:
[29-298]
-----------------------------------------------------
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
--------
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
WG
S
--
F
L
C
E
L
W
T
S
----------
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
------------------------
A
I
S
-----------------
A
L
V
--
S
--
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
DPGCCDF
V
-----------------------
T
N
----------------------
R
----------------------
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
----
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
--
K
----
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
Y
--
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
---------
A
-----
16
PsiBlast_PDB
82.88
25%
-196
- C1 -
2YCY
6
ADRB1_MELGA
A:
[29-299]
-----------------------------------------------------
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
--------
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
WG
S
--
F
L
C
E
L
W
T
S
----------
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
------------------------
A
I
S
-----------------
A
L
V
--
S
--
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
DPGCCDF
V
-----------------------
T
N
----------------------
R
----------------------
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
----
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
---------------
A
S
K
R
K
R
V
M
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
M
R
E
H
K
----
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
Y
--
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
---------
A
F
----
14
PsiBlast_PDB
82.84
25%
-193
- C1 -
2YCX
3
ADRB1_MELGA
A:
[29-294]
-----------------------------------------------------
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
--------
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
WG
S
--
F
L
C
E
L
W
T
S
----------
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
------------------------
A
I
S
-----------------
A
L
V
--
S
--
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
DPGCCDF
V
-----------------------
T
N
----------------------
R
----------------------
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
----
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
---------------
A
S
K
R
K
R
V
M
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
M
R
E
H
K
----
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
Y
--
A
--
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
------------------