@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O11A1_HUMAN: (2016-01-11 )
MEIVSTGNETITEFVLLGFYDIPELHFLFFIVFTAVYVFIIIGNMLIIVAVVSSQRLHKPMYIFLANLSFLDILYTSAVMPKMLEGFLQEATISVAGCLLQFFIFGSLATAECLLLAVMAYDRYLAICYPLHYPLLMGPRRYMGLVVTTWLSGFVVDGLVVALVAQLRFCGPNHIDQFYCDFMLFVGLACSDPRVAQVTTLILSVFCLTIPFGLILTSYARIVVAVLRVPAGASRRRAFSTCSSHLAVVTTFYGTLMIFYVAPSAVHSQLLSKVFSLLYTVVTPLFNPVIYTMRNKEVHQALRKILCIKQTETLD
Atome Classification :
(20 SA)
.........10...----.....20......----..30........40..---......50........60........70........-80---........90.-........-100......------------.110.......120.......130.......140.......150.......160......-----.170.......180.......190.......200....--...210.......220---------......-------.230..-----------------.-----....240.---..----....250......--------.------------260.....---..-------270.......280-........290.......300....---...310...------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
I
VSTG
N
E
T
I
T
E
F
----
V
L
L
GFYDI
P
E
L
H
F
----
L
F
F
I
V
F
T
A
V
Y
V
F
I
I
IG---N
M
L
I
I
V
A
VVSSQRLHK
P
M
Y
I
F
L
A
N
L
S
F
L
D
I
L
Y
TS
A
V
-
M
P
---
K
M
L
E
G
F
L
Q
E
-
A
-
T
I
S
V
A
G
C
L
-
L
Q
F
F
I
FG
S
L
------------
A
T
A
E
C
L
L
L
A
V
M
A
YD
R
Y
L
A
I
C
YPLHYPLLMGP
R
R
Y
M
G
L
V
V
T
T
W
L
S
G
F
V
V
D
G
L
V
V
A
L
V
A
Q
L
R-----FCG
P
N
H
I
D
Q
F
Y
C
D
F
M
L
F
V
GLACSDP
R
V
A
Q
V
T
T
L
I
L
S
V
F
--
C
L
T
I
P
F
G
L
I
L
T
S
Y
A
R
I
---------
V
V
A
V
L
R-------VPAGA
S
-----------------
R
-----
R
R
A
F
S
T
C
S
---
S
H
----
L
A
V
V
T
T
F
Y
G
T
L
M
I
--------
F
------------
Y
VA
P
S
A
V
H
---
S
Q
-------
L
L
S
K
V
F
S
L
L
Y
T
V
--
V
T
P
L
F
N
P
V
I
Y
TMR
N
K
E
V
H
Q
A
L
R
K
I
L
---CIKQTETLD------------
17
PsiBlast_PDB
92.04
25%
-170
- C8 -
2YDO
3
?
A:
[15-312]
------------------------------------------
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
------
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
------------
A
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
-
G
L
T
P
M
L
--
G
W
N
-----
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
---------
F
L
A
A
R
R
Q
L
K
Q
M
E
S--------------------------------
T
L
Q
K
E
---
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------------
F
F
C
P
D
C
S
H
---
A
P
-------
L
W
L
M
Y
L
A
I
V
L
S
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
------------
18
PsiBlast_PDB
91.42
25%
-171
- C8 -
2YDV
6
?
A:
[15-312]
------------------------------------------
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
------
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
------------
A
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
-
G
L
T
P
M
L
--
G
W
N
-----
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
---------
F
L
A
A
R
R
Q
L
K
Q
M
ES
Q
------------------------------
S
T
L
Q
K
E
---
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------------
F
F
C
P
D
C
S
H
---
A
P
-------
L
W
L
M
Y
L
A
I
V
L
S
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
------------
6
PsiBlast_PDB
91.37
24%
-166
- C8 -
3UZC
1
AA2AR_HUMAN
A:
[15-305]
------------------------------------------
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
------
A
C
H
G
C
L
-
F
I
A
C
F
V
L
V
L
------------
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
-
G
L
T
P
M
L
--
G
W
N
-----
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
FA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
---------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------------
R
-----
A
R
S
T
L
Q
K
E
---
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
A
--------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
P
-------
L
W
L
M
Y
L
A
I
V
L
A
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S----------------------
3
PsiBlast_PDB
91.07
24%
-168
- C8 -
3REY
1
AA2AR_HUMAN
A:
[15-305]
------------------------------------------
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
------
A
C
H
G
C
L
-
F
I
A
C
F
V
L
V
L
------------
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
-
G
L
T
P
M
L
--
G
W
N
-----
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
FA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
---------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------------
R
-----
A
R
S
T
L
Q
K
E
---
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
A
--------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
P
-------
L
W
L
M
Y
L
A
I
V
L
A
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S----------------------
5
PsiBlast_PDB
90.74
24%
-165
- C8 -
3UZA
1
AA2AR_HUMAN
A:
[15-305]
------------------------------------------
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
------
A
C
H
G
C
L
-
F
I
A
C
F
V
L
V
L
------------
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
-
G
L
T
P
M
L
--
G
W
N
-----
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
FA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
---------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------------
R
-----
A
R
S
T
L
Q
K
E
---
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
A
--------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
P
-------
L
W
L
M
Y
L
A
I
V
L
A
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S----------------------
2
PsiBlast_PDB
90.68
24%
-163
- C8 -
3PWH
1
?
A:
[15-305]
------------------------------------------
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
------
A
C
H
G
C
L
-
F
I
A
C
F
V
L
V
L
------------
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
-
G
L
T
P
M
L
--
G
W
N
-----
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
FA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
---------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------------
R
-----
A
R
S
T
L
Q
K
E
---
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
A
--------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
P
-------
L
W
L
M
Y
L
A
I
V
L
A
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S----------------------
4
PsiBlast_PDB
90.47
24%
-166
- C8 -
3RFM
1
AA2AR_HUMAN
A:
[15-305]
------------------------------------------
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
------
A
C
H
G
C
L
-
F
I
A
C
F
V
L
V
L
------------
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
-
G
L
T
P
M
L
--
G
W
N
-----
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
FA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
---------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------------
R
-----
A
R
S
T
L
Q
K
E
---
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
A
--------
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
P
-------
L
W
L
M
Y
L
A
I
V
L
A
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S----------------------
20
PsiBlast_PDB
90.15
25%
-174
- C8 -
4UHR
1
AA2AR_HUMAN
A:
[15-312]
------------------------------------------
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
------
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
------------
A
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
-
G
L
T
P
M
L
--
G
W
N
-----
N
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
FA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
---------
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------------
R
-----
A
R
S
T
L
Q
K
E
---
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------------
F
F
C
P
D
C
-
H
---
A
P
-------
L
W
L
M
Y
L
A
I
V
L
S
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
------------
19
PsiBlast_PDB
89.61
25%
-175
- C8 -
4UG2
3
?
A:
[15-309]
------------------------------------------
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
------
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
------------
A
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
-
G
L
T
P
M
L
--
G
W
N
-----
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
---------
F
L
A
A
R
R
Q
L----------------------------------
A
R
S
T
L
Q
K
E
---
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------------
F
F
C
P
D
C
S
H
---
A
P
-------
L
W
L
M
Y
L
A
I
V
L
S
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
SH
V
L
R
------------------
10
PsiBlast_PDB
85.47
22%
-170
- C8 -
4QKX
2
ADRB2_HUMAN
A:
[187-463]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----------------
F
G
A
A
C
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
-----
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
---------
F
Q
E
A
K
R
-------
Q
L
Q
--------------------
K
FAL
K
E
H
K
A
L
K
T
L
G
---
I
I
----
M
G
T
F
T
L
C
W
L
P
F
F
I
--------
V
------------
N
I
V
H
V
I
Q
D
---
N
L
-------
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
---
C
L
-------------------
9
PsiBlast_PDB
85.26
22%
-168
- C8 -
4LDO
3
A:
[187-463]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----------------
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
-----
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
---------
F
Q
E
A
K
R
-------
Q
L
Q
--------------------
K
FAL
K
E
H
K
A
L
K
T
L
G
---
I
I
----
M
G
T
F
T
L
C
W
L
P
F
F
I
--------
V
------------
N
I
V
H
V
I
Q
D
---
N
L
-------
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
---
C
L
-------------------
8
PsiBlast_PDB
85.20
22%
-169
- C8 -
4LDL
3
ADRB2_HUMAN
A:
[187-463]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----------------
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
-----
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
---------
F
Q
E
A
K
R
-------
Q
L
Q
--------------------
K
FA
L
K
E
H
K
A
L
K
T
L
G
---
I
I
----
M
G
T
F
T
L
C
W
L
P
F
F
I
--------
V
------------
N
I
V
H
V
I
Q
D
---
N
L
-------
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
---
C
L
-------------------
7
PsiBlast_PDB
84.80
22%
-166
- C8 -
4LDE
3
A:
[187-463]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----------------
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
-----
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
---------
F
Q
E
A
K
R
-------
Q
L
Q
--------------------
K
FAL
K
E
H
K
A
L
K
T
L
G
---
I
I
----
M
G
T
F
T
L
C
W
L
P
F
F
I
--------
V
------------
N
I
V
H
V
I
Q
D
---
N
L
-------
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
---
C
L
-------------------
71
Fugue
83.73
18%
-137
- C6 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
NKTG
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
AE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
-
L
E
G
F
F
A
T
L
G
------------
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
I
D
----
Y
Y
T
P
---------
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
--
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---------
V
F
T
V
K
E
-------
A
A
A
S
A
T
-----------------
T
-----
Q
K
A
E
K
E
V
T
---
R
M
----
V
I
I
M
V
I
A
F
L
I
C
W
L
--------
P
------------
Y
A
G
V
A
F
Y
I
---
F
T
H
QGSDFG
P
I
F
M
T
I
P
A
F
F
A
K
--
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
---
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A
1
PsiBlast_PDB
82.87
21%
-166
- C8 -
4GBR
1
ADRB2_HUMAN
A:
[10-286]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----------------
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
-----
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
---------
F
Q
E
A
K
R
-------
Q
L
Q
K
I
D
-----------------
K
FC
L
K
E
H
K
A
L
K
T
L
G
---
I
I
----
M
G
T
F
T
L
C
W
L
P
F
F
I
--------
V
------------
N
I
V
H
V
I
Q
D
---
N
L
-------
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
---
C
L
-------------------
66
HHSearch
82.74
16%
-165
- C6 -
2Z73
5
OPSD_TODPA
A:
[32-331]
---------------------------
A
V
Y
Y
----
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
---
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
-
V
Y
G
F
I
G
G
I
F
------------
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
-----
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
-----
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
--
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
---------
V
M
S
V
S
N
-------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----
N
A
E
M
R
L
A
K
I
S
I
V
I
----
V
S
Q
F
L
L
S
W
S
P
Y
A
V
--------
V
------------
A
L
L
A
Q
F
G
P
LEW
V
T
-------
P
Y
A
A
Q
L
P
V
M
F
A
K
--
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
---
P
W
V
L
T
C
C
Q
F
------------
16
PsiBlast_PDB
80.70
22%
-158
- C8 -
2RH1
9
ADRB2_HUMAN (first)
A:
[45-315]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----------------
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
-----
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
-------
I
D
E
G
L
------------------
R
-----
L
K
I
Y
K
D
T
E
---
G
Y
----
Y
---
T
I
G
I
G
H
L
L
T
--------
K
------------
S
P
S
L
N
A
A
K
---
S
E
-------
L
D
K
A
I
G
R
N
T
N
G
V
--
I
T
K
D
E
A
E
K
L
F
---
N
Q
D
V
D
A
A
V
R
G
I
L
---
R
N
A
K
L
K
P
V
Y
------------
11
PsiBlast_PDB
79.89
22%
-160
- C8 -
3D4S
6
ENLYS_BPT4
A:
[46-316]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----------------
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
-----
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
QLN
I
F
E
M
L
R
-------
I
D
E
G
L
------------------
R
-----
L
K
I
Y
K
D
T
E
---
G
Y
----
Y
---
T
I
G
I
G
H
L
L
T
--------
K
------------
S
P
S
L
N
A
A
K
---
S
E
-------
L
D
K
A
I
G
R
N
T
N
G
V
--
I
T
K
D
E
A
E
K
L
F
---
N
Q
D
V
D
A
A
V
R
G
I
L
---
R
N
A
K
L
K
P
V
Y
------------
12
PsiBlast_PDB
79.21
22%
-155
- C8 -
3NY8
7
ENLYS_BPT4
A:
[46-316]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----------------
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
-----
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
-------
I
D
E
G
L
------------------
R
-----
L
K
I
Y
K
D
T
E
---
G
Y
----
Y
---
T
I
G
I
G
H
L
L
T
--------
K
------------
S
P
S
L
N
A
A
K
---
S
E
-------
L
D
K
A
I
G
R
N
T
N
G
V
--
I
T
K
D
E
A
E
K
L
F
---
N
Q
D
V
D
A
A
V
R
G
I
L
---
R
N
A
K
L
K
P
V
Y
------------
14
PsiBlast_PDB
79.16
22%
-155
- C8 -
3NYA
3
ADRB2_HUMAN (first)
A:
[46-316]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----------------
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
-----
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
-------
I
D
E
G
L
------------------
R
-----
L
K
I
Y
K
D
T
E
---
G
Y
----
Y
---
T
I
G
I
G
H
L
L
T
--------
K
------------
S
P
S
L
N
A
A
K
---
S
E
-------
L
D
K
A
I
G
R
N
T
N
G
V
--
I
T
K
D
E
A
E
K
L
F
---
N
Q
D
V
D
A
A
V
R
G
I
L
---
R
N
A
K
L
K
P
V
Y
------------