@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O4F15_HUMAN: (2016-01-12 )
MNGMNHSVVSEFVFMGLTNSREIQLLLFVFSLLFYFASMMGNLVIVFTVTMDAHLHSPMYFLLANLSIIDMAFCSITAPKMICDIFKKHKAISFRGCITQIFFSHALGGTEMVLLIAMAFDRYMAICKPLHYLTIMSPRMCLYFLATSSIIGLIHSLVQLVFVVDLPFCGPNIFDSFYCDLPRLLRLACTNTQELEFMVTVNSGLISVGSFVLLVISYIFILFTVWKHSSGGLAKALSTLSAHVTVVILFFGPLMFFYTWPSPTSHLDKYLAIFDAFITPFLNPVIYTFRNKDMKVAMRRLCSRLAHFTKIL
Atome Classification :
(20 SA)
---------------------------------------------------........--------.10...----------------.--....---------------20........30.....-.------..40........50......-..60.....-...70-.......-..80.....-...90....------------....100....-...110....------------...120.......130...---....140.......150-........160.......170.....-..180....------...-----190-----....--.....200....-....210.......220--........-.230----------.---------------------........240.---......250--------........260--.--.----------.---.--.---...---------270-------------........280.......290---...--.....300---------------.......310------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------MNGM
N
H
S
V
--------
V
S
E
F
V
F
----------------M--GLTN---------------SRE
I
Q
L
L
L
F
V
F
S
L
L
F
Y
F
-
A
------
S
M
MG
N
L
V
I
V
F
T
V
TMDAHLHS-
P
M
Y
F
L
L
ANL-
S
I
I
D
--
M
A
F
CSIT-
A
P
K
M
I
C
D
I
F
-
K
KHKA
I
S
F
R
------------
G
C
I
T
Q
I
F
F
S
HA-LGG
T
E
M
V
L
L
I
------------
A
M
A
F
D
R
Y
M
A
I
C
K
P
L
H
Y
L
T
I---MSP
R
M
C
L
Y
F
L
A
T
S
S
I
I
--
G
L
I
H
S
L
V
Q
L
V
F
V
VDLPFCG
P
N
I
F
D
S
F
-
Y
C
D
L
P
R
L
L
R
------
L
AC-----T-------NTQ
E
--
L
E
F
M
V
T
V-NS
G
L
-
I
S
V
G
S
F
V
L
L
V
I
S
Y
I
F
----
I
L
F
T
V
W
KH-SS------------G---------------------
G
L
A
K
A
L
S
T
L
S
A
H
---
V
T
V
V
I
L
FF---------G
P
L
M
F
F
Y
TWP---S--
P
----------
T
---
S
--
H
---
L
D
K
---------
Y
L
--------------
A
I
F
D
A
F
I
T
P
F
L
N
P
V
I
Y
T
FRN----K
D
M
--
K
V
A
M
R
R
L
C
---------------
S
R
L
A
H
F
T
KIL------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
92.09
18%
-131
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------------------------------------------------------
M
N
G
T
E
--------
G
P
N
F
Y
V
PFSNKTGVVRSPFEAP
Q
--
Y
Y
L
A
---------------
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
-
L
------
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
-
A
V
A
D
--
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
------------
G
C
N
L
E
G
F
F
A
T
L
-
G
G
E
I
A
L
W
S
L
V
------------
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
------------
F
G
E
N
H
A
I
M
--
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
------
W
-
S
R
Y
I
P
E
G
M
Q
------
C
S
C
-----
G
I
DYYTPH
E
E
T
N
--
N
E
S
F
V
I
Y
-
M
F
V
V
-
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
----
L
V
F
T
V
K
E
A
A
A
S
------------
A
---------------------
T
T
Q
K
A
E
K
E
V
T
R
M
---
V
I
I
M
V
I
A
F
---------
L
I
C
W
L
P
Y
A
G
V
---
A
--
F
----------
Y
---
I
--
F
---
T
H
Q
GSDFGPIFM
T
I
--------------
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
----
K
Q
F
--
R
N
C
M
V
T
T
L
---------------
C
C
G
K
N
P
S
T
T
V
SKTETS
Q
V
A
P
A-------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
89.28
16%
-146
- C3 -
2Z73
5
OPSD_TODPA
A:
[33-335]
------------------------------------------------------------------------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
-
I
------
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
-
P
A
N
M
F
I
I
N
L
-
A
F
S
D
--
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
------------
A
C
K
V
Y
G
F
I
G
G
I
-
F
G
F
M
S
I
M
T
M
A
------------
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
--
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
----
E
G
V
L
C
-
N
C
S
F
D
Y
I
S
-----------------------
R
D
S
T
--
T
R
S
N
I
L
C
-
M
F
I
L
-
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
----
I
V
M
S
V
S
N
H
-
E
K
------------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
---
V
S
Q
F
L
L
S
W
---------
S
P
Y
A
V
V
A
L
L
A
---
Q
--
F
----------
G
PLE
W
VT
P
---
Y
A
A
---------
Q
L
--------------
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
----
P
K
F
--
R
E
A
I
S
Q
T
F
---------------
P
W
V
L
T
C
C
Q
F
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
87.38
18%
-136
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---------------------------------------------------
M
N
G
T
E
G
P
----------
N
F
Y
V
P
----------------
F
--
S
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
-
L
------
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
-
A
V
A
D
--
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
------------
G
C
N
L
E
G
F
F
A
T
L
-
G
G
E
I
A
L
W
S
L
V
------------
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
------------
F
G
E
N
H
A
I
M
--
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
-------
I
P
E
G
M
Q
------
C
S
C
G
I
DYY
T
-------
P
H
E
E
--
T
N
N
E
S
F
V
-
I
Y
M
F
-
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
--
L
V
F
T
V
K
E
A
-
A
A
------------
Q
---------------------
Q
Q
E
S
A
T
T
Q
K
A
E
K
---
E
V
T
R
M
V
I
I
---------
M
V
I
A
F
L
I
C
W
L
---
P
--
Y
----------
A
---
G
--
V
---
A
F
Y
---------
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
----
K
Q
F
--
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
PA----------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
84.29
16%
-144
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
---------------------------------------------------------------------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
-
T
------
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
-
V
T
N
Y
F
L
V
N
L
-
A
F
A
E
--
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
------------
Y
C
K
F
H
N
F
F
P
I
A
-
A
V
F
A
S
I
Y
S
M
T
------------
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
S
-----
A
T
A
T
K
V
V
I
C
V
I
W
V
L
--
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
-
E
T
----
M
P
S
R
V
-
V
C
M
I
E
W
P
E
H
--------------
P
-------
N
K
I
Y
--
E
K
V
Y
H
I
C
-
V
T
V
L
-
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
----
V
G
I
T
L
W
A
S
-
E
I
PGDSSDRYH
E
Q
V
S
---------------------
A
K
R
K
V
V
K
M
M
I
V
V
---
V
C
T
F
A
I
C
W
---------
L
P
F
H
I
F
F
L
L
P
---
Y
--
I
NPD-------
L
Y--
L
K-
K
FI
Q
Q
V
Y
---------
L
A
--------------
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
----
D
R
F
--
R
L
G
F
K
H
A
F
---------------
R
C
C
P
F
I
S
A
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
79.08
16%
-146
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-328]
--------------------------------------------------------------------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
-
L
------
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
-
A
V
A
D
--
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
------------
G
C
N
L
E
G
F
F
A
T
L
-
G
G
E
I
A
L
W
S
L
V
------------
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
--
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
----
E
G
M
Q
C
-
S
C
G
I
D
Y
Y
T
---------
P
-----
H
-------
E
E
T
N
--
N
E
S
F
V
I
Y
-
M
F
V
V
-
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
----
L
V
F
T
V
K
E
A
-
A
A
------------
Q
QQESA
T
T
Q
K
------------
A
E
K
E
V
T
R
M
V
I
I
M
---
V
I
A
F
L
I
C
W
---------
L
P
Y
A
G
V
A
F
Y
I
---
F
T
H
Q
----------
G
S--
D
FG
P
---
I
F
M
---------
T
I
--------------
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
----
K
Q
F
--
R
N
C
M
V
T
T
L
---------------
C
C
G
K
N
P
L
G
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
73.37
17%
-125
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
-------------------------------------------------------------------------------------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
-
L
------
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
-
V
T
D
V
Y
L
L
N
L
-
A
L
A
D
--
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
------------
L
C
K
V
V
S
L
L
K
E
V
-
N
F
Y
S
G
I
L
L
L
A
------------
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
----
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
--
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
P
----
N
N
S
S
P
-
V
C
Y
E
V
L
G
N
---------------
D
-------
T
A
K
W
--
R
M
V
L
R
I
L
-
P
H
T
F
-
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
----
T
L
R
T
L
F
K
A
-
H
M
------------
G
---------------------
Q
K
H
R
A
M
R
V
I
F
A
V
---
V
L
I
F
L
L
C
W
---------
L
P
Y
N
L
V
L
L
A
D
---
T
--
L
M
RTQVIQE
S
C
E
R
R
-
N
--
N
I
G
-
R
A
L
---------
D
A
--------------
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
----
Q
N
F
--
R
H
G
F
L
K
I
L
---------------
A
M
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
71.86
10%
-122
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------------------------------------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
-
A
------
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
-
V
T
N
Y
F
I
T
S
L
-
A
C
A
D
--
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
------------
W
C
E
F
W
T
S
I
D
V
L
-
C
V
T
A
S
I
E
T
L
C
------------
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
--
S
G
L
T
S
F
L
P
I
Q
M
-------
H
W
Y
R
A
T
H
Q
-
E
A
I
N
C
Y
A
E
E
------
T
C
C
-----
D
-------
F
F
T
N
--
Q
A
Y
A
I
A
S
-
S
I
V
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
----
F
Q
E
A
K
R
Q
L
-
N
I
------------
F
---------------------
E
M
L
R
I
D
E
G
L
R
L
K
---
I
Y
K
D
T
E
G
Y
---------
Y
T
I
G
I
G
H
L
L
T
---
K
--
S
----------
P
---
S
--
L
---
N
A
A
---------
K
S
--------------
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
----
K
L
F
--
N
Q
D
V
D
A
A
V
---------------
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
59
Fugue
69.39
15%
-173
* C4 *
1YNH
2
ASTB_ECOLI
A:
[14-452]
A
W
E
V
N
F
D
G
LVGLTHHYAGLSFGN
E
A
S
T
R
H
RFQVSN
P
R
L
A
A
K
Q
G
L
L
K
M
K
A
L
A
D
A
G
F
P
Q
A
V
I
P
P
H
ERPF
I
P
V
L
R
Q
----------------
L
--
G
F
S
G
---------------
S
D
E
Q
V
L
E
K
V
A
R
Q
A
P
H
W
L
-
S
S
V
S
SAS
P
M
W
V
A
N
A
A
T
I
A
P
S
A
D
T
L
-
D
G
-
K
V
H
L
T
V
A
N
L
N
N
K
F
H
--
R
S
L
E
A
P
V
-
T
E
S
L
L
K
A
I
F
-
N
D
E
E
K
F
S
V
H
S
A
LPQVALLGDE
G
A
A
N
H
N
R
L
G
G
H
-
Y
G
E
P
G
M
Q
L
F
V
Y
GREEGNDTRPS
R
Y
P
A
R
Q
T
R
E
A
S
E
A
V
A
R
L
N
Q
---
V
N
P
Q
Q
V
I
F
A
Q
Q
N
P
D
V
I
D
Q
G
V
F
H
N
D
V
I
A
V
S
N
R
Q
V
L
F
C
H
Q
Q
A
F
A
R
Q
-
S
Q
L
L
A
N
L
R
A
R
V
NGFM
A
I
E
-----
V
-------
P
A
T
Q
--
V
S
V
S
D
T
V
-
S
T
Y
L
-
F
N
S
-
Q
L
L
S
R
D
D
G
S
M
M
----
L
V
L
P
Q
E
C
R
-
E
H
------------
A
---------------------
G
V
W
G
Y
L
N
E
L
L
A
A
DNP
I
S
E
L
K
V
F
D
L
R
E
S
M
A
N
GG
G
P
A
C
L
R
L
R
V
V
L
T
E
E
--
E
----------
R
---
R
--
A
---
V
N
P
---------
A
V
--------------
M
M
N
D
T
L
F
N
A
L
N
D
W
V
D
R
Y
Y
R
D
RLTA
A
D
L
AD
P
Q
L
L
R
E
G
R
---------------
E
A
L
D
V
L
S
Q
L
L
NLGSVYPFQR--------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
68.04
11%
-151
- C1 -
1V9D
1
DIAP1_MOUSE
A:
[6-337]
---------------------------------------------VKELKV
L
D
S
K
T
A
Q
N
--------
L
S
I
F
L
G
----------------
S
--
F
R
M
P
---------------
Y
Q
E
I
K
N
V
I
L
E
V
N
E
A
V
L
T
-
E
------
S
M
I
Q
N
L
I
K
Q
M
P
E
P
E
Q
L
K
M
L
S
-
E
L
K
E
E
Y
D
D
L
-
A
E
S
E
--
Q
F
G
V
V
M
G
-
T
V
P
R
---
L
R
-
P
R
L
N
A
I
L
F
K
------------
L
Q
F
S
E
Q
V
E
N
------------
I
------------
K
P
E
I
V
S
V
T
A
A
C
E
E
L
R
K
S
E
N
---
F
S
S
L
L
-
S
F
L
C
K
L
R
D
T
K
--
S
A
D
Q
K
M
T
L
L
H
F
L
A
E
L
C
E
N
D
H
P
E
V
L
K
F
-
P
D
E
L
A
H
V
E
K
------
A
S
R
-----
V
-------
S
A
E
N
--
L
Q
K
S
L
D
Q
-
M
K
K
Q
-
I
A
D
V
E
R
D
V
Q
N
F
P
A
A
T
DEKD
K
F
V
E
K
M
T
S
-
F
V
------------
K
---------------------
D
A
Q
E
Q
Y
N
K
L
R
M
M
---
H
S
N
M
E
T
L
Y
---------
K
E
L
G
D
Y
F
V
F
D
---
P
--
K
----------
K
---
L
--
S
---
V
E
E
---------
F
F
--------------
M
D
L
H
N
F
R
N
M
F
L
Q
A
V
K
E
N
Q
K
R
----
R
E
T
--
E
E
K
M
R
R
A
K
---------------
L
A
K
E
K
A
E
K
E
R
L-----------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
65.09
19%
-148
- C3 -
3EML
8
ENLYS_BPT4
A:
[22-219]
--------------------------------------------------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
-
L
------
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
-
V
T
N
Y
F
V
V
S
L
-
A
A
A
D
--
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
------------
G
C
L
F
I
A
C
F
V
L
V
-
L
T
Q
S
S
I
F
S
L
L
------------
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
--
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
-
G
C
G
E
G
Q
---------
V
A
C
-----
L
-------
F
E
D
V
VP
M
N
Y
M
V
Y
F
-
N
F
F
A
-
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
----
I
F
L
A
A
R
R
Q
-
L
N
------------
I
---------------------
F
E
M
L
R
I
D
E
G
L
R
L
---
K
I
Y
K
D
T
E
G
---------
Y
Y
T
I
G
I
G
H
L
L
---
T
--
K
----------
S
---
P
--
S
---
L
N
A
---------
A
K
--------------
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
----
E
K
L
--
F
N
Q
D
V
D
A
A
---------------
V
R
G
I
L
R
N
A
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
64.71
16%
-146
- C2 -
4QIK
8
RC3H1_HUMAN
A:
[4-313]
---------------------------------------------GVE
D
T
K
H
Y
E
E
A
K
K
C
--------
V
E
E
L
A
L
----------------
Y
L
K
P
L
S
S
---------------
A
R
G
V
G
L
N
S
T
T
Q
S
V
L
S
R
P
M
Q
------
R
K
L
V
T
L
V
H
C
Q
L
V
E
E
E
G
R
I
R
A
M
R
A
A
R
S
L
G
E
R
-
T
V
T
E
--
L
I
L
Q
H
Q
N
-
P
Q
Q
L
S
S
N
L
W
-
A
A
V
R
A
---
R
------------
G
C
Q
---
F
L
G
P
A
M
Q
--
E
E
A
L
K
L
V
------------
L
L
A
L
E
D
G
S
A
L
S
R
K
V
L
V
L
F
V
---
V
Q
R
L
E
P
R
F
P
Q
A
S
K
T
S
I
--
G
H
V
V
Q
L
L
Y
R
A
----------
S
C
F
K
S
L
M
Q
L
K
E
E
F
R
T
Y
------
E
A
L
-----
R
-------
R
E
H
D
--
S
Q
I
V
Q
I
A
M
E
A
G
L
R
I
A
P
D
Q
W
S
S
L
L
Y
G
D
Q
-----------
S
H
-
K
S
------------
H
M
--------------------
Q
S
I
I
D
K
L
Q
T
P
A
S
---
F
A
Q
S
V
Q
E
L
---------
T
I
A
L
Q
R
T
G
D
P
---
A
--
N
----------
L
---
N
--
R
---
L
R
P
---------
H
L
--------------
E
L
L
-
A
N
I
D
P
S
P
D
A
P
P
P
T
W
E
Q
L
---
E
N
G
--
L
V
A
V
R
T
V
V
---------------
H
G
L
V
D
Y
I
Q
N
H
------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
60.89
18%
-145
- C3 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-224]
----------------------------------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
-
A
------
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
-
T
T
N
Y
L
V
V
S
L
-
A
V
A
D
--
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
------------
C
C
D
V
F
V
T
L
D
V
M
-
M
C
T
A
S
I
W
N
L
C
------------
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
--
A
F
A
V
S
C
P
L
L
F
G
F
N
T
T
-------
G
D
P
T
-
V
C
S
I
----------------------------
S
N
P
---
D
-
F
V
I
Y
-
S
S
V
V
-
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
----
I
Y
V
V
L
K
Q
R
-
R
R
------------
K
---------------------
N
I
F
E
M
L
R
I
D
E
G
L
---
R
L
K
I
Y
K
D
T
---------
E
G
Y
Y
T
I
G
I
G
H
---
L
--
L
----------
T
---
K
--
S
---
P
S
L
---------
N
A
--------------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
----
E
A
E
--
K
L
F
N
Q
D
V
D
---------------
A
A
V
R
G
I
L
R
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
59.28
14%
-129
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-233]
-------------------------------------------------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
-
A
------
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
-
V
T
N
Y
F
I
T
S
L
-
A
C
A
D
--
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
------------
W
C
E
F
W
T
S
I
D
V
L
-
C
V
T
A
S
I
E
T
L
C
------------
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
--
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
-
H
---
Q
E
A
I
-
N
C
Y
A
E
----------
E
T
C
-----
C
-------
D
F
F
T
--
N
Q
A
Y
A
I
A
-
S
S
I
V
-
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
----
V
F
Q
E
A
K
R
Q
-
L
N
------------
I
---------------------
F
E
M
L
R
I
D
E
G
L
R
L
---
K
I
Y
K
D
T
E
G
---------
Y
Y
T
I
G
I
G
H
L
L
---
T
--
K
----------
S
---
P
--
S
---
L
N
A
---------
A
K
--------------
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
----
E
K
L
--
F
N
Q
D
V
D
A
A
---------------
V
R
G
I
L
R
N
A
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
59.13
13%
-145
- C3 -
3UON
2
ACM2_HUMAN (first)
A:
[25-213]
---------------------------------------------------------------------------------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
-
V
------
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
-
V
N
N
Y
F
L
F
S
L
-
A
C
A
D
--
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
------------
V
C
D
L
W
L
A
L
D
Y
V
-
V
S
N
A
S
V
M
N
L
L
------------
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
--
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
V
--
R
T
V
E
D
G
-
E
C
Y
I
Q
F
---------------------------
F
S
--
N
A
A
V
T
F
G
-
T
A
I
A
-
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
----
I
S
R
A
S
K
S
R
-
I
N
------------
I
---------------------
F
E
M
L
R
I
D
E
G
L
R
L
---
K
I
Y
K
D
T
E
G
---------
Y
Y
T
I
G
I
G
H
L
L
---
T
--
K
----------
S
---
P
--
S
---
L
N
A
---------
A
K
--------------
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
----
E
K
L
--
F
N
Q
D
V
D
A
A
---------------
V
R
G
I
L
R
N
A
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
56.21
14%
-134
- C3 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-198]
---------------------------------------------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
-
V
------
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
-
V
G
N
L
Y
I
V
S
L
-
S
V
A
D
--
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
------------
L
C
L
F
W
L
S
M
D
Y
V
-
A
S
T
A
S
I
F
S
V
F
------------
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
--
S
F
L
W
V
I
P
I
L
G
-
W
N
H
--------
R
R
E
D
-
K
C
E
T
D
F
Y
---------------------------
D
--
V
T
W
F
K
V
M
-
T
A
I
I
-
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
----
I
Y
K
A
V
R
Q
H
-
C
N
------------
I
---------------------
F
E
M
L
R
I
D
E
G
L
R
L
---
K
I
Y
K
D
T
E
G
---------
Y
Y
T
I
G
I
G
H
L
L
---
T
--
K
----------
S
---
P
--
S
---
L
N
A
---------
A
K
--------------
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
----
E
K
L
--
F
N
Q
D
V
D
A
A
---------------
V
R
G
I
L
R
N
A
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
53.57
15%
-138
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[48-236]
-------------------------------------------------------------------------------------------------------------------
K
I
F
L
P
T
I
Y
S
I
I
F
L
-
T
------
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
-
M
T
D
K
Y
R
L
H
L
-
S
V
A
D
--
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
------------
L
C
K
A
V
H
V
I
Y
T
V
-
N
L
Y
S
S
V
W
I
L
A
------------
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
--
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
-----
A
D
D
R
Y
-
I
C
D
R
F
Y
P
------------------------
N
D
L
W
--
V
V
V
F
Q
F
Q
-
H
I
M
V
-
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
----
I
I
S
K
L
S
H
S
-
G
S
------------
N
---------------------
I
F
E
M
L
R
I
D
E
G
L
R
---
L
K
I
Y
K
D
T
E
---------
G
Y
Y
T
I
G
I
G
H
L
---
L
--
T
----------
K
---
S
--
P
---
S
L
N
---------
A
A
--------------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
----
A
E
K
--
L
F
N
Q
D
V
D
A
---------------
A
V
R
G
I
L
R
N
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
53.11
15%
-130
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[63-247]
-------------------------------------------------------------------------------------------------------------------
I
K
L
T
S
V
V
F
I
L
I
C
C
-
F
------
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
-
P
M
Y
Y
F
I
G
N
L
-
A
L
S
D
--
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
A
------------
Q
W
F
L
R
E
G
S
M
F
V
-
A
L
S
A
S
V
F
S
L
L
------------
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
--
S
L
I
L
G
G
L
P
I
M
G
W
N
C
I
-------
S
A
L
S
-
S
C
S
T
V
L
P
-------------------------
L
Y
---
H
K
H
Y
-
I
L
-
F
C
T
T
-
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
----
I
Y
S
L
V
R
T
R
-
N
I
------------
F
---------------------
E
M
L
R
I
D
E
G
L
R
L
K
---
I
Y
K
D
T
E
G
Y
---------
Y
T
I
G
I
G
H
L
L
T
---
K
--
S
----------
P
---
S
--
L
---
N
A
A
---------
K
S
--------------
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
----
K
L
F
--
N
Q
D
V
D
A
A
V
---------------
R
G
I
L
R
N
A
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
52.84
15%
-141
- C4 -
1SRV
-
A:
[192-336]
---------------------------------------------------------------------
G
Y
Q
F
----------------
D
--
K
G
Y
I
---------------
S
P
Y
F
V
T
---------
N
P
-
E
------
T
M
E
A
V
L
E
D
A
F
I
L
I
V
E
K
K
V
S
--------------------------------------------
N
------------
V
R
E
L
L
P
I
L
E
Q
V
-
A
Q
T
G
K
P
L
L
I
I
------------
A
E
D
V
E
--------------------
G
E
A
L
A
T
L
V
V
N
K
L
R
--
G
T
L
S
-----
V
A
A
V
K
A
P
G
F
G
----
D
R
R
-
K
E
M
L
K
D
I
A
A
------
V
T
G
-----
G
-------
T
V
I
S
--
E
E
L
G
F
K
L
-
E
N
---------------------------
A
T
L
-
S
M
------------
L
---------------------
G
R
A
E
R
V
R
I
T
K
-------
D
E
T
T
I
V
---------
G
-------
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
44.73
24%
-126
- C3 -
3C9L
3
OPSD_BOVIN
A:
[55-143]
--------------------------------------------------------------------------------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
-
A
V
A
D
L
F
M
V
F
G
G
F
T
-
T
--
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
------------
G
C
N
L
E
G
F
F
A
T
L
-
G
G
E
I
A
L
W
S
L
V
------------
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
--
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
-
Y
Y
T
P
H
E
E
T
N
------
N
E
S
-----
F
-------
V
I
Y
M
--
F
V
V
H
F
I
I
-
P
L
I
V
-
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
----
A
A
Q
Q
Q
E
S
A
-
T
T
------------
Q
---------------------
K
A
E
K
E
V
T
R
M
V
I
I
---
M
V
I
A
F
L
I
C
---------
W
L
P
Y
A
G
V
A
F
Y
---
I
--
F
----------
T
---
H
--
Q
---
G
S
D
---------
F
G
--------------
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
--
M
M
N
K
Q
F
R
N
---------------
C
M
V
T
T
L
C
C
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
44.66
24%
-123
- C3 -
1F88
2
OPSD_BOVIN
A:
[55-143]
--------------------------------------------------------------------------------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
-
A
V
A
D
L
F
M
V
F
G
G
F
T
-
T
--
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
------------
G
C
N
L
E
G
F
F
A
T
L
-
G
G
E
I
A
L
W
S
L
V
------------
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
--
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
-
Y
Y
T
P
H
E
E
T
N
------
N
E
S
-----
F
-------
V
I
Y
M
--
F
V
V
H
F
I
I
-
P
L
I
V
-
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
----
A
A
S
A
T
T
Q
K
-
A
E
------------
K
---------------------
E
V
T
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
---------
A
G
V
A
F
Y
I
F
T
H
---
Q
--
G
----------
S
---
D
--
F
---
G
P
I
---------
F
M
--------------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
----
M
N
K
--
Q
F
R
N
C
M
V
T
---------------
T
L
C
C
G
K
N
P
S
T
------------------------------------------------------------------------------------------------------------------------------------------------------------