@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O51B6_HUMAN: (2016-01-12 )
MGLNKSASTFQLTGFPGMEKAHHWIFIPLLAAYISILLGNGTLLFLIRNDHNLHEPMYYFLAMLAATDLGVTLTTMPTVLGVLWLDHREIGHGACFSQAYFIHTLSVMESGVLLAMAYDCFITIRSPLRYTSILTNTQVMKIGVRVLTRAGLSIMPIVVRLHWFPYCRSHVLSHAFCLHQDVIKLACADITFNRLYPVVVLFAMVLLDFLIIFFSYILILKTVMGIGSGGERAKALNTCVSHICCILVFYVTVVCLTFIHRFGKHVPHVVHITMSYIHFLFPPFMNPFIYSIKTKQIQSGILRLFSLPHSRA
Atome Classification :
(20 SA)
--------.........10...----------------.....20........30........----40........50........60........70....-..----..80........90........100........110........120.......130.......140...--.....150.-...--------....160...-----.....170----.......180......-------.190.......200.......210.......220----..---------....------------------------------------------------------------------------------------------------------------------------------------------------------------------.230-----...--------......-----240..------------.....250----------........260...--..---..270.......280.......290.......300.......310--------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------MGLNKSA
S
T
F
Q
L
TG----------------FPGMEKAH
H
W
I
F
I
P
L
L
A
A
Y
I
S
I
L
LG----N
G
T
L
L
F
L
I
RNDHNLH
E
P
M
Y
Y
F
L
A
M
L
A
ATDL
G
V
T
L
T
T
-
M
P
----
T
V
L
G
V
L
WLDHREIGHG
A
C
FS
Q
A
Y
F
-
I
H
T
L
S
V
M
ES-
G
V
L
L
A
M
A
Y
D
C
F
I
T
IRSP
L
R
Y
T
SILTN
T
Q
V
M
K
-
I
G
V
--
R
V
L
T
RA-G
L
-
S
I
M
--------
P
I
V
V
R
-LH
W
F
-----
P
Y
C
R
S
H
V
L
----
S
H
A
F
C
L
H
Q
D
V
I
K
L
A
C
A-------DI
T
F
N
R
L
Y
P
V
V
V
L
F
A
M
V
L
L
D
F
L
I
I
F
F
S
Y
I
L
I
L
K
T
----
V
M
---------GIGS------------------------------------------------------------------------------------------------------------------------------------------------------------------GG-------
E
R
A
--------
K
A
L
N
T
C
-----
V
S
H
I
C
------------
C
I
L
V
F
Y
V
-----------
T
V
V
C
L
T
F
I
H
R
F
G
KH--V
P
---
H
V
V
H
I
T
M
S
Y
I
H
F
LFPPFM
N
P
F
I
Y
S
I
K
T
K
Q
I
Q
S
G
I
L
R
L
FSLPHSRA--------------------
2
PsiBlast_PDB
90.09
24%
-153
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[14-297]
-----------------------------------------------------
L
A
I
A
V
L
A
I
L
G
----
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
-
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
-
V
L
V
L
T
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
--
C
W
V
L
S
F
-
A
I
-
G
L
T
--------
P
M
----
L
G
W
N
NCGQ---
S
Q
G
C
G
E
----
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
-------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
----
M
E
---------
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
-------
E
R
A
--------
R
S
T
L
Q
K
-----
E
V
H
A
A
------------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
1
PsiBlast_PDB
89.71
24%
-152
- C4 -
3VG9
8
?
A:
[14-297]
-----------------------------------------------------
L
A
I
A
V
L
A
I
L
G
----
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
-
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
-
V
L
V
L
T
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
--
C
W
V
L
S
F
-
A
I
-
G
L
T
--------
P
M
----
L
G
W
N
NCGQ---
S
Q
G
C
G
E
----
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
-------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
----
M
E
---------
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
-------
E
R
A
--------
R
S
T
L
Q
K
-----
E
V
H
A
A
------------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
27
HHSearch
89.64
18%
-164
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[37-477]
------------------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
----
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
-
D
V
L
C
V
T
A
S
I
-
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
-
I
I
L
--
M
V
W
I
V
S
-
G
L
-
T
S
F
--------
L
P
I
Q
M
H
W
Y
R
A
-----
T
H
-----
Q
----
E
A
I
N
C
Y
A
E
E
----
T
C
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
----
A
K
---------
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF-
C
L
-------
K
E
H
--------
K
A
L
K
T
L
-----
G
I
I
M
G
------------
T
F
T
L
C
W
L
-----------
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
--
L
I
---
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------
44
Fugue
89.50
15%
-141
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--------
M
N
G
T
E
G
-
P
N
F
Y
V
P
F
SNKTGVVRSPFEAPQY
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
----
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
-
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
-
V
A
F
--
T
W
V
M
A
L
-
A
C
-
A
A
P
--------
P
L
V
G
W
-
S
R
Y
I
-----
P
E
G
-------------------
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
---------
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
TTQK
A
E
K
E
V
T
--------
R
M
V
I
I
M
-----
V
I
A
F
L
------------
I
C
W
L
P
Y
A
-----------
G
V
A
F
Y
I
F
T
H
Q
--
G
S
--
D
F
---
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A------
10
PsiBlast_PDB
89.28
24%
-149
- C4 -
3PWH
1
?
A:
[14-297]
-----------------------------------------------------
L
A
I
A
V
L
A
I
L
G
----
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
-
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
-
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
--
C
W
V
L
S
F
-
A
I
-
G
L
T
--------
P
M
----
L
G
W
N
NCGQP--------GCGE
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
-------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
----
M
E
---------
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
-------
E
R
A
--------
R
S
T
L
Q
K
-----
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
------------
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
--
W
L
M
Y
L
A
I
V
L
A
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
11
PsiBlast_PDB
89.23
24%
-149
- C4 -
3REY
1
AA2AR_HUMAN
A:
[14-297]
-----------------------------------------------------
L
A
I
A
V
L
A
I
L
G
----
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
-
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
-
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
--
C
W
V
L
S
F
-
A
I
-
G
L
T
--------
P
M
----
L
G
W
N
NCGQP--------GCGE
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
-------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
----
M
E
---------
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
-------
E
R
A
--------
R
S
T
L
Q
K
-----
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
------------
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
--
W
L
M
Y
L
A
I
V
L
A
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
14
PsiBlast_PDB
88.65
24%
-152
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[14-297]
-----------------------------------------------------
L
A
I
A
V
L
A
I
L
G
----
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
-
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
-
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
--
C
W
V
L
S
F
-
A
I
-
G
L
T
--------
P
M
----
L
G
W
N
NCGQP--------GCGE
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
-------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
----
M
E
---------
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
-------
E
R
A
--------
R
S
T
L
Q
K
-----
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
------------
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
--
W
L
M
Y
L
A
I
V
L
A
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
6
PsiBlast_PDB
88.60
25%
-154
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[14-297]
-----------------------------------------------------
L
A
I
A
V
L
A
I
L
G
----
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
A
I
S
-
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
-
V
L
V
L
T
A
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
-
I
I
A
I
C
W
V
L
S
F
A
I
G
L
-
T
P
M
LGWNNCGQ
P
K
E
G
K
-
A
------------
G
C
G
E
----
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
-------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
----
M
E
---------
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
-------
E
R
A
--------
R
S
T
L
Q
K
-----
E
V
H
A
A
------------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
--
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------------
12
PsiBlast_PDB
88.48
24%
-150
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[14-297]
-----------------------------------------------------
L
A
I
A
V
L
A
I
L
G
----
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
-
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
-
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
--
C
W
V
L
S
F
-
A
I
-
G
L
T
--------
P
M
----
L
G
W
N
NCGQP--------GCGE
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
-------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
----
M
E
---------
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
-------
E
R
A
--------
R
S
T
L
Q
K
-----
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
------------
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
--
W
L
M
Y
L
A
I
V
L
A
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
13
PsiBlast_PDB
88.11
24%
-154
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[14-297]
-----------------------------------------------------
L
A
I
A
V
L
A
I
L
G
----
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
-
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
-
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
--
C
W
V
L
S
F
-
A
I
-
G
L
T
--------
P
M
----
L
G
W
N
NCGQP--------GCGE
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
-------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
----
M
E
---------
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
-------
E
R
A
--------
R
S
T
L
Q
K
-----
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
------------
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
--
W
L
M
Y
L
A
I
V
L
A
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
3
PsiBlast_PDB
87.65
25%
-159
- C4 -
2YDO
3
?
A:
[14-297]
-----------------------------------------------------
L
A
I
A
V
L
A
I
L
G
----
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
A
I
S
-
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
-
V
L
V
L
T
A
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
-
I
I
A
I
C
W
V
L
S
F
A
I
G
L
-
T
P
M
LGWNNCGQ
P
K
E
G
K
-
A
H
---------
S
Q
G
C
G
E
----
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
-------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
----
M
E
---------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
-----
E
V
H
A
A
------------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------------
4
PsiBlast_PDB
86.70
25%
-159
- C4 -
2YDV
6
?
A:
[14-297]
-----------------------------------------------------
L
A
I
A
V
L
A
I
L
G
----
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
A
I
S
-
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
-
V
L
V
L
T
A
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
-
I
I
A
I
C
W
V
L
S
F
A
I
G
L
-
T
P
M
LGWNNCGQ
P
K
E
G
K
-
A
H
---------
S
Q
G
C
G
E
----
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
-------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
----
M
E
---------
S
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
-----
E
V
H
A
A
------------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------------
5
PsiBlast_PDB
86.44
25%
-157
- C4 -
4UG2
3
?
A:
[14-297]
-----------------------------------------------------
L
A
I
A
V
L
A
I
L
G
----
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
A
I
S
-
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
-
V
L
V
L
T
A
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
-
I
I
A
I
C
W
V
L
S
F
A
I
G
L
-
T
P
M
LGWNNCGQ
P
K
E
G
K
-
A
H
---------
S
Q
G
C
G
E
----
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
-------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------
R
S
T
L
Q
K
-----
E
V
H
A
A
------------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
----
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
45
Fugue
86.26
16%
-144
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
PFE-------------
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
----
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
-
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
-
V
A
F
--
T
W
V
M
A
L
-
A
C
-
A
A
P
--------
P
L
V
G
W
-
S
R
Y
I
-----
P
E
G
-------------------
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
EAAAQQQES
A
T
T
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
-------
E
K
E
--------
V
T
R
M
V
I
-----
I
M
V
I
A
------------
F
L
I
C
W
L
P
-----------
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
---
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
GDDEA
S
T
T
V
S
K
TETSQVAPA
20
PsiBlast_PDB
85.66
23%
-158
- C4 -
2YCZ
2
ADRB1_MELGA
A:
[25-299]
-----------------------------------------------------------
I
V
A
G
----
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
------
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
-
I
I
C
--
T
V
W
A
I
S
-
A
L
V
S
F
L
--------
P
I
M
---
M
H
W
W
---------
R
D
E
D
----
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
---------
K
I
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
-------
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
------------
W
L
P
F
F
L
V
-----------
N
I
V
-----
N
V
F
N
R
D
L-
V
P
---
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
-
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------------
18
PsiBlast_PDB
85.66
23%
-156
- C4 -
2YCW
7
ADRB1_MELGA
A:
[25-299]
-----------------------------------------------------------
I
V
A
G
----
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
------
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
-
I
I
C
--
T
V
W
A
I
S
-
A
L
V
S
F
L
--------
P
I
M
---
M
H
W
W
---------
R
D
E
D
----
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
---------
K
I
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
-------
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
------------
W
L
P
F
F
L
V
-----------
N
I
V
-----
N
V
F
N
R
D
L-
V
P
---
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
-
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------------
31
HHSearch
85.61
19%
-174
- C4 -
3EML
13
ENLYS_BPT4
A:
[21-471]
---------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
----
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
-
V
L
V
L
T
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
-
I
I
A
--
I
C
W
V
L
S
-
F
A
-
I
G
L
--------
T
P
M
L
G
-
W
N
N
C
-----
G
Q
-----------
S
Q
G
C
G
E
G
Q
V
---
A
C
L
FE-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
----
A
R
---------
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
Q
-------
K
E
V
--------
H
A
A
K
S
L
-----
A
I
I
V
G
------------
L
F
A
L
C
W
L
-----------
P
L
H
I
I
N
C
F
T
F
F
C
P
D
CS
H
A
---
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------------
17
PsiBlast_PDB
84.22
23%
-158
- C4 -
2VT4
8
ADRB1_MELGA
A:
[25-298]
-----------------------------------------------------------
I
V
A
G
----
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
------
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
-
I
I
C
--
T
V
W
A
I
S
-
A
L
V
S
F
L
--------
P
I
M
---
M
H
W
W
---------
R
D
E
D
----
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
------------
W
L
P
F
F
L
V
-----------
N
I
V
-----
N
V
F
N
R
D
L-
V
P
---
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
-
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------
19
PsiBlast_PDB
83.67
23%
-154
- C4 -
2YCX
3
ADRB1_MELGA
A:
[25-294]
-----------------------------------------------------------
I
V
A
G
----
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
------
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
-
I
I
C
--
T
V
W
A
I
S
-
A
L
V
S
F
L
--------
P
I
M
---
M
H
W
W
---------
R
D
E
D
----
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
---------
K
I
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
-------
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
------------
W
L
P
F
F
L
V
-----------
N
I
V
-----
N
V
F
N
R
D
L-
V
P
---
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
-
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
------------------------------
32
HHSearch
83.17
16%
-156
- C4 -
2Z73
5
OPSD_TODPA
A:
[31-333]
------------------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
----
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
----
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
-
G
G
I
F
G
F
M
S
I
-
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
-
M
I
I
--
F
V
W
L
W
S
-
V
L
-
W
A
I
--------
G
P
I
F
G
-
W
G
A
Y
-----
T
L
----
E
G
----
V
L
C
N
C
S
F
D
Y
I
S
------------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
----
V
S
---------
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
N
-------
A
E
M
--------
R
L
A
K
I
S
-----
I
V
I
V
S
------------
Q
F
L
L
S
W
S
-----------
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E-
W
V
---
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
--------------------