@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2L8_HUMAN: (2016-01-13 )
MENYNQTSTDFILLGLFPPSRIDLFFFILIVFIFLMALIGNLSMILLIFLDTHLHTPMYFLLSQLSLIDLNYISTIVPKMASDFLHGNKSISFTGCGIQSFFFLALGGAEALLLASMAYDRYIAICFPLHYLIRMSKRVCVLMITGSWIIGSINACAHTVYVLHIPYCRSRAINHFFCDVPAMVTLACMDTWVYEGTVFLSATIFLVFPFIGISCSYGQVLFAVYHMKSAEGRKKAYLTCSTHLTVVTFYYAPFVYTYLRPRSLRSPTEDKVLAVFYTILTPMLNPIIYSLRNKEVMGALTRVSQRICSVKM
Atome Classification :
(20 SA)
.........10........20.-------------.......30........40--.........50..---......60........70.....-...80........90........100.......110.-......120.......130.......140.......150.......160--------------------.......170.......180......-------.-------190.-......200....-----...210------------------........220-----..-----------.....230------------------.....-------------....240...------....------250..----.....260...---.---..-.270.........280.....-..290.......300.-----------------......310--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MENYNQTST
D
F
I
L
L
GLFPP
S
R
I
-------------
D
L
F
F
F
I
L
I
V
F
I
F
L
M
A
L
IG---
N
L
S
M
I
L
L
I
F
LDTH---LH
T
P
M
Y
F
L
L
S
Q
L
S
L
I
D
L
N
Y
I
S
T
I
-
V
P
K
M
A
S
D
F
LHGNK
S
I
S
F
TG
C
G
I
Q
S
F
F
F
L
ALGG
A
E
A
L
L
-
L
A
S
M
AYD
R
Y
I
A
I
C
F
P
L
H
Y
L
I
R
MSK
R
V
C
V
L
M
I
TG
S
W
I
I
G
S
I
N
A
C
A
H
T
V
Y
V
--------------------
L
HIPYCRSRAIN
H
F
FCD
V
P
A
M
V
T
L
A
C
-------
M
-------
D
T
W
V-YE
G
T
V
F
L
S
A
T
I
F
L
-----
V
F
P
F
I-------------------GISCS
Y
G
Q
V
L
F
-----
A
V
-----------
Y
HMKSA--------------------EGR
K
K
-------------
A
Y
L
T
CST
H
L
T
------
V
V
T
F
------
Y
Y
A
P
F
----
V
Y
T
YLRPRSLR---S---PT-E
D
--
K
V
L
A
V
F
Y
T
I
L
T
P
M
L
N
P
I
-
I
Y
S
LRN
K
E
V
M
G
A
L
T
R
V
-----------------
S
Q
R
I
CSVKM--
8
PsiBlast_PDB
91.97
24%
-144
- C3 -
3C9L
13
OPSD_BOVIN
A:
[37-312]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
EA
A
A
-----------
Q
Q
Q
E
S
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
D
D
E
--
30
HHSearch
91.41
16%
-136
* C3 *
2KS9
1
NK1R_HUMAN
A:
[35-324]
--------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
---
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
-
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
---------------------
T
--
T
-
E
-
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-----------------
N
K
I
Y
-
E
K
V
Y
H
I
C
V
T
V
L
I
Y
-----
F
L
P
L
L
-------------------
V
I
G
Y
A
Y
T
V
V
G
I
-----
T
L
-----------
W
A
S
E
I
P
GDSSDRYH
E
Q
V
---------
S
A
K
R
K
-------------
V
V
K
M
M
I
V
V
V
C
------
T
F
A
I
------
C
W
L
P
F
----
H
I
F
F
L
L
P
Y
I
N
P
---
D
LYL
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
-
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
-----------------
F
R
C
C
P
F
I
S
A
--
9
PsiBlast_PDB
90.29
24%
-144
- C3 -
1F88
7
OPSD_BOVIN
A:
[37-312]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G
------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
TVKEA
A
A
---------------
S
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
P
S
T
--
10
PsiBlast_PDB
90.02
24%
-141
- C3 -
3DQB
4
GNAT1_BOVIN (first)
A:
[37-312]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
-----------
Q
Q
Q
E
S
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
-----
35
HHSearch
90.01
16%
-143
- C3 -
2Z73
5
OPSD_TODPA
A:
[35-334]
------------------------------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
---
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
-
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
--------------------
G
A
---
Y
T
-
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
-------------------
D
S
T
-
T
R
S
N
I
L
C
M
F
I
L
G
F
-----
F
G
P
I
L
-------------------
I
I
F
F
C
Y
F
N
I
V
M
-----
S
V
-----------
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
-------------
L
A
K
I
S
I
V
I
V
S
------
Q
F
L
L
------
S
W
S
P
Y
----
A
V
V
A
L
L
A
Q
F
G
P
LEW
V
---
T
P
-
Y
A
--
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
-
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
-----------------
F
P
W
V
L
T
C
C
Q
--
19
PsiBlast_PDB
89.85
24%
-143
- C3 -
2I35
4
OPSD_BOVIN
A:
[37-312]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G
------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
EA
A
A
-----------
Q
Q
Q
E
S
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
D
D
E
--
11
PsiBlast_PDB
89.59
24%
-142
- C3 -
3PQR
9
OPSD_BOVIN
A:
[37-312]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
-----------
Q
Q
Q
E
S
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
-----
7
PsiBlast_PDB
88.83
24%
-144
- C3 -
3CAP
4
OPSD_BOVIN
A:
[37-312]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
-----------
Q
Q
Q
E
S
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
-----
13
PsiBlast_PDB
88.80
24%
-140
- C3 -
4J4Q
8
GNAT1_BOVIN (first)
A:
[37-312]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
-----------
Q
Q
Q
E
S
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
-----
18
PsiBlast_PDB
88.77
24%
-147
- C3 -
2I36
1
OPSD_BOVIN
A:
[37-312]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G
------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
-----------
Q
Q
Q
E
S
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
-----
12
PsiBlast_PDB
88.72
24%
-143
- C3 -
3PXO
4
OPSD_BOVIN
A:
[37-312]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
-----------
Q
Q
Q
E
S
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
-----
43
Fugue
88.70
18%
-129
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
RSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
---
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
KK
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
-
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
----------------------------------
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
-
N
E
S
F
V
I
Y
M
F
V
V
H
F
-----
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
-----
T
V
KEAAASA----
T
T
Q
K
A
E
--------------------
K
E
V
T
R
-------------
M
V
I
I
M
V
I
A
F
L
------
I
C
W
L
------
P
Y
A
G
V
----
A
F
Y
I
F
T
H
Q
G
S
D
---
F
---
G
P
-
I
F
--
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPSTTV------
S
K
T
E
T
S
Q
V
A
P
A
14
PsiBlast_PDB
88.56
24%
-142
- C3 -
4PXF
7
OPSD_BOVIN
A:
[37-312]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
-----------
Q
Q
Q
E
S
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
-----
17
PsiBlast_PDB
87.19
24%
-127
- C3 -
1HZX
14
OPSD_BOVIN
A:
[40-313]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G
------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
TVKEA
A
A
----------------
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
P
L
G
--
5
PsiBlast_PDB
85.95
23%
-131
- C3 -
3C9M
1
OPSD_BOVIN
A:
[37-312]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
-----
T
V
-----------
K
E
A
A
A
Q
--------------------
Q
Q
E
S
A
-------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
----
F
Y
I
F
T
H
Q
G
S
C
F
---
G
---
P
I
-
F
M
--
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
P
----
16
PsiBlast_PDB
85.20
24%
-124
- C3 -
1GZM
15
OPSD_BOVIN
A:
[40-313]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
EA
A
A
-----------
Q
Q
Q
E
S
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
D
D
E
--
15
PsiBlast_PDB
85.11
24%
-120
- C3 -
3OAX
16
OPSD_BOVIN
A:
[40-313]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
TVKEA
A
A
-----------
Q
Q
Q
E
S
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
P
L
G
--
20
PsiBlast_PDB
85.03
24%
-122
- C3 -
2HPY
13
OPSD_BOVIN
A:
[40-313]
--------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
--------------------
G
W
S
R
Y
------------
I
P
E
G
M
Q
C
S
C
G
------
I
-------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
TVKEA
A
A
-----------
Q
Q
Q
E
S
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
F
------
Y
I
F
T
H
----
Q
G
S
D
F
G
P
I
F
M
T
---
I
---
P
----------
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------------
L
C
C
G
K
N
P
L
G
--
47
Fugue
84.17
17%
-119
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
S
F
K
C
A
L
T
K
T
G
F
----------
Q
-------------
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
---
N
S
V
A
I
W
M
F
V
F
H
M
K
---
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
-
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
KNKTITCYDTTSDEY
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
-------
Y
-------
G
L
I
V
-
R
A
L
I
Y
K
M
K
K
Y
T
C
T
-----
V
C
G
Y
I
Y
N
PEDGDPDNGVNPGTDFK
D
I
V
C
P
L
C
G
V
G
K
-----
D
Q
-----------
F
E
E
V
E
E
--------------------
P
L
R
R
K
-------------
S
I
Y
L
V
I
I
V
L
T
------
V
F
A
V
------
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
---
T
---
P
A
-
M
C
--
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
-----------------
F
R
R
R
-------
42
Fugue
83.23
18%
-112
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
--
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
RSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
-
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
----------------------------------
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
-
N
E
S
F
V
I
Y
M
F
V
V
H
F
-----
I
I
P
L
I
-------------------
V
I
F
F
C
Y
G
Q
L
V
F
-----
T
V
KEAAAQQQESA
T
T
Q
K
A
E
--------------------
K
E
V
T
R
-------------
M
V
I
I
M
V
I
A
F
L
------
I
C
W
L
------
P
Y
A
G
V
----
A
F
Y
I
F
T
H
Q
G
S
D
---
F
---
G
P
-
I
F
--
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
PA