@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5DI_HUMAN: (2016-01-13 )
MLLTDRNTSGTTFTLLGFSDYPELQVPLFLVFLAIYNVTVLGNIGLIVIIKINPKLHTPMYFFLSQLSFVDFCYSSIIAPKMLVNLVVKDRTISFLGCVVQFFFFCTFVVTESFLLAVMAYDRFVAICNPLLYTVNMSQKLCVLLVVGSYAWGVSCSLELTCSALKLCFHGFNTINHFFCEFSSLLSLSCSDTYINQWLLFFLATFNEISTLLIVLTSYAFIVVTILKMRSVSGRRKAFSTCASHLTAITIFHGTILFLYCVPNSKNSRHTVKVASVFYTVVIPMLNPLIYSLRNKDVKDTVTEILDTKVFSY
Atome Classification :
(20 SA)
--------.........10........20----.----.......30......---------..40........50........60...-.....70.......-.80......-..90-......---..100.......110-.....--....120.......130....---...140.......150.......160.......170.......180.......190-----.-------.---..--.....200---........--.210--........220.....-..230-----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------.-----------------......240..-.....250----........260....------------.----.------------.------270.-----------....--..280-........290..-.....300.......310.-----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------
M
L
LTDRNTSG
T
T
F
T
L
LGFSDY----P----EL
Q
V
P
L
F
L
V
F
L
A
I
Y
N
---------
V
T
V
LGNI
G
L
I
V
I
I
K
INPKLH
T
P
M
Y
F
F
L
-
S
Q
L
S
F
V
D
F
C
Y
S
SII-
A
P
K
M
L
V
N
L
V
-VKDR-
T
I
S
F
L
G
---
C
V
V
Q
F
F
F
F
C
T
F
V
V
---
T
E
S
F
L
--
L
A
V
M
A
Y
D
R
F
V
A
I
C
N
P
L
L
Y
TVN---MSQ
K
L
C
V
L
L
V
VGSYAWG
V
S
C
S
L
E
L
T
C
S
A
L
K
L
C
F
H
G
F
N
T
I
N
H
F
F
C
E
F
S
S
L
L
SLSC-------
S
-------
D
---
T
Y
--
I
N
Q
W
L
L
-----
F
F
L
A
T
F
N
E
--
I
S
T
---
L
L
I
V
L
T
S
Y
A
F
I
V
V
T
I
L
-
K
M
RS------------------------------------------------------------------------------------------------------------------------------------------------------------------V-------------------------------------------------------------------------------------------------------------------------------------------------------------------S-----------------G
R
R
K
A
F
S
T
C
A
S
-
H
L
T
A
I
T
I
-----FHG
T
I
L
F
L
Y
C
VPNSK------------N----S------------
R
------
H
T
V
K
-----------
V
A
S
V
--
F
Y
T
V
--
V
I
P
M
L
N
P
L
I
Y
S
L
R-NK
D
V
K
D
T
V
T
E
I
L
DTKVFSY-----------------------------
39
Fugue
84.62
15%
-132
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
----
Y
LAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
---------
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
---
C
N
L
E
G
F
F
A
T
L
G
G
E
---
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
--------------
M
Q
C
S
C
-------
G
I
DYYTPH
E
---
E
T
--
N
N
E
S
F
V
-----
I
Y
M
F
V
V
H
F
--
I
I
P
---
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------
T
T
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
------------
G
----
S
------------
D
------
F
G
P
I
-----------
F
M
T
I
P
A
F
F
A
K
--
T
S
A
V
Y
N
P
V
I
Y
I
M
M
-
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A---------------
22
HHSearch
84.52
19%
-145
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
----------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
---------
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
-
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
-
T
F
G
N
F
W
---
C
E
F
W
T
S
I
D
V
L
C
V
T
---
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
----
T
H
Q
E
A
I
N
C
Y
A
E
E
----
T
C
-------
C
-------
D
---
F
F
--
T
N
Q
A
Y
A
-----
I
A
S
S
I
V
S
F
--
Y
V
P
---
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF-
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----------------
K
E
H
K
A
L
K
T
L
G
I
-
I
M
G
T
F
T
L
-----
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
------------
D
NL--
I
------------
R
------
K
E
V
Y
-----------
I
L
L
N
--
W
I
G
Y
--
V
N
S
G
F
N
P
L
I
Y
C
-
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------
24
HHSearch
83.12
19%
-149
* C1 *
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
---------
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
-
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
-
S
L
G
R
P
L
---
C
L
F
W
L
S
M
D
Y
V
A
S
T
---
A
S
I
F
S
--
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
-
N
H
--------
R
R
E
D
K
C
E
T
D
F
Y
D
----------------------------
V
T
W
F
K
-----
V
M
T
A
I
I
N
F
--
Y
L
P
---
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
-
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------------
R
E
R
K
A
A
K
Q
L
G
F
-
I
M
A
A
F
I
L
-----
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
------------
K
----
N
CC----------
N
------
E
H
L
H
-----------
M
F
T
I
--
W
L
G
Y
--
I
N
S
T
L
N
P
L
I
Y
P
L
C
-
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------------------------
21
HHSearch
81.80
19%
-150
- C1 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-----------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
---------
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
-
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
-
P
L
G
P
V
V
---
C
D
L
W
L
A
L
D
Y
V
V
S
N
---
A
S
V
M
N
--
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
--
G
V
R
T
V
E
D
G
E
C
Y
I
Q
F
F
----------------------------
S
N
A
A
V
T
-----
F
G
T
A
I
A
A
F
--
Y
L
P
---
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
-
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
R
E
K
K
V
T
R
T
I
L
A
-
I
L
L
A
F
I
I
-----
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
------------
A
PC--
I
------------
P
------
N
T
V
W
-----------
T
I
G
Y
--
W
L
C
Y
--
I
N
S
T
I
N
P
A
C
Y
A
L
C
-
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------------
40
Fugue
80.33
15%
-132
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
YLAE
P
----
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
---------
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
---
C
N
L
E
G
F
F
A
T
L
G
G
E
---
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
--------------
M
Q
C
S
C
G
I
DYYTP
H
-------
E
---
E
T
--
N
N
E
S
F
V
-----
I
Y
M
F
V
V
H
F
--
I
I
P
---
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----------------
Q
E
S
A
T
T
Q
K
A
E
K
-
E
V
T
R
M
V
I
-----
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
------------
V
----
A
------------
F
------
Y
I
F
T
H
QGSDFGPIFM
T
I
P
A
--
F
F
A
K
--
T
S
A
V
Y
N
P
V
I
Y
I
M
M
-
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
GDDEA
S
T
T
V
S
K
TETSQVAPA---------
27
HHSearch
80.07
16%
-152
- C1 -
3EML
13
ENLYS_BPT4
A:
[21-469]
----------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
---------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
-
C
A
A
C
H
G
---
C
L
F
I
A
C
F
V
L
V
L
T
Q
---
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
---
A
C
-------
L
-------
F
---
E
D
VV
P
M
N
Y
M
V
-----
Y
F
N
F
F
A
C
V
--
L
V
P
---
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----------------
K
E
V
H
A
A
K
S
L
A
I
-
I
V
G
L
F
A
L
-----
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
------------
P
DCSH
A
------------
P
------
L
W
L
M
-----------
Y
L
A
I
--
V
L
S
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-----------------------------
32
HHSearch
77.29
18%
-148
- C1 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
---------
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
-
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
-
N
F
S
R
I
C
---
C
D
V
F
V
T
L
D
V
M
M
C
T
---
A
S
I
W
N
--
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
-------
T
G
D
P
T
V
C
S
I
S
N
P
-----------------------------
D
--
F
V
-----
I
Y
S
S
V
V
S
F
--
Y
L
P
---
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
-
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
-----------------
R
E
K
K
A
T
Q
M
V
A
I
-
V
L
G
A
F
I
V
-----
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
------------
Q
TCH-
V
------------
S
------
P
E
L
Y
-----------
S
A
T
T
--
W
L
G
Y
--
V
N
S
A
L
N
P
V
I
Y
T
T
F
-
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------------------------
28
HHSearch
74.74
16%
-145
- C1 -
2KS9
1
NK1R_HUMAN
A:
[33-324]
-----------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
---------
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
-
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
-
Y
Y
G
L
F
Y
---
C
K
F
H
N
F
F
P
I
A
A
V
F
---
A
S
I
Y
S
--
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
-----
E
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-----------------
N
---
K
I
--
Y
E
K
V
Y
H
-----
I
C
V
T
V
L
I
Y
--
F
L
P
---
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
-
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
A
K
R
K
V
V
K
M
M
I
V
-
V
V
C
T
F
A
I
-----
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
------------
P
----
D
------------
L
YLKKFI
Q
Q
V
Y
-----------
L
A
I
M
--
W
L
A
M
--
S
S
T
M
Y
N
P
I
I
Y
C
C
L
-
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
-----------------------------
30
HHSearch
74.46
15%
-138
- C1 -
2Z73
5
OPSD_TODPA
A:
[32-333]
--------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
---------
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
-
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
-
I
F
G
F
A
A
---
C
K
V
Y
G
F
I
G
G
I
F
G
F
---
M
S
I
M
T
--
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
----
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
----------------------
D
S
--
T
T
R
S
N
I
-----
L
C
M
F
I
L
G
F
--
F
G
P
---
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
-
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------------
A
E
M
R
L
A
K
I
S
I
V
-
I
V
S
Q
F
L
L
-----
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
------------
P
LEW-
V
------------
T
------
P
Y
A
A
-----------
Q
L
P
V
--
M
F
A
K
--
A
S
A
I
H
N
P
M
I
Y
S
V
S
-
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
-----------------------------
31
HHSearch
73.73
14%
-129
- C1 -
1U19
14
OPSD_BOVIN
A:
[40-327]
----------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
---------
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
---
C
N
L
E
G
F
F
A
T
L
G
G
E
---
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
--
Y
--
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
-----------------
E
---
E
T
--
N
N
E
S
F
V
-----
I
Y
M
F
V
V
H
F
--
I
I
P
---
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------
A
E
K
E
V
T
R
M
V
I
I
-
M
V
I
A
F
L
I
-----
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QGS---------
D
----
F
------------
G
------
P
I
F
M
-----------
T
I
P
A
--
F
F
A
K
--
T
S
A
V
Y
N
P
V
I
Y
I
M
M
-
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
-----------------------------
29
HHSearch
72.51
17%
-132
- C1 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
--------------------------------------
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
---------
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
-
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
-
K
L
T
P
A
Q
---
W
F
L
R
E
G
S
M
F
V
A
L
S
---
A
S
V
F
S
--
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
W
N
C
-------
I
S
A
L
S
S
C
S
T
V
L
P
L
------------------------
Y
---
H
K
H
Y
I
-----
L
F
-
C
T
T
V
F
--
T
L
L
---
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
-
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
E
N
V
A
L
L
K
T
V
I
I
-
V
L
S
V
F
I
A
-----
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
------------
K
----
V
KTC
D
--------
I
------
L
F
R
A
-----------
E
Y
F
L
--
V
L
A
V
--
L
N
S
G
T
N
P
I
I
Y
T
L
T
-
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
--------------------------------
23
HHSearch
68.55
16%
-134
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-496]
--------------------------------------
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
---------
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
-
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
-
Y
F
G
N
F
L
---
C
K
A
V
H
V
I
Y
T
V
N
L
Y
---
S
S
V
W
I
--
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
-----
S
E
A
D
D
R
Y
I
C
D
R
F
Y
P
N
D
-----------------------
L
--
W
V
V
V
F
Q
-----
F
Q
H
I
M
V
G
L
--
I
L
P
---
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
-
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
-----------------
Q
K
R
K
A
L
K
T
T
V
I
-
L
I
L
A
F
F
A
-----
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
----
T
------------
V
------
H
K
W
I
-----------
S
I
T
E
--
A
L
A
F
--
F
H
C
C
L
N
P
I
L
Y
A
F
L
-
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
-----------------------------
48
Fugue
68.43
16%
-132
- C1 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
---------------
S
F
K
C
A
L
T
K
T
G
F
-------------
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
---------
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
-
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
-
I
F
G
D
A
M
---
C
K
L
Q
R
F
I
F
H
V
N
L
Y
---
G
S
I
L
F
--
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
--
K
S
L
G
---
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
---
S
P
I
L
F
Y
S
G
T
G
V
R
K
N
K
T
I
T
C
Y
D
T
T
-------------
S
-------
D
---
E
Y
--
L
R
S
Y
F
I
-----
Y
S
M
C
T
T
V
A
MF
C
V
P
---
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
C
TVCG
Y
I
Y
N
PEDGDPDN
G
V
N
P
G
T
D
F
K
D
I
-
V
C
P
L
C
G
V
-----
G
K
D
Q
F
E
E
V
E
E
P
L
R
R
K
------------
S
----
I
------------
Y
------
L
V
I
I
-----------
V
L
T
V
--
F
A
V
S
--
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR
33
HHSearch
65.25
15%
-128
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
---------------------------------------
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
---------
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
-
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
-
I
F
G
T
F
L
---
C
K
V
V
S
L
L
K
E
V
N
F
Y
---
S
G
I
L
L
--
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
--
Y
--
H
P
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
------------------
T
---
A
K
--
W
R
M
V
L
R
-----
I
L
P
H
T
F
G
F
--
I
V
P
---
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
-
K
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----------------
Q
K
H
R
A
M
R
V
I
F
A
-
V
V
L
I
F
L
L
-----
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
------------
R
----
T
QVIQE
S
C
E
R
R
N
N
I
------
G
R
A
L
-----------
D
A
T
E
--
I
L
G
F
--
L
H
S
C
L
N
P
I
I
Y
A
F
I
-
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------
42
Fugue
58.10
14%
-133
- C1 -
3ZPJ
-
?
A:
[1-356]
-M
T
T
L
E
E
I
N
L
L
V
E
R
G
Y
Y
E
E
A
L
A
K
V
Y
E
I
E
D
----
P
----
I
E
Q
V
Q
V
L
T
K
I
V
V
T
I
Y
Q
H
DGPMEW
I
P
S
I
M
E
D
A
M
Y
I
A
K
K
L
R
D
P
A
N
K
A
V
A
Y
S
I
I
A
S
T
L
A
I
M
E
Y
E
E
D
A
M
D
-
F
F
N
R
A
I
D
E
A
-
N
E
I
E
-
S
P
I
E
K
G
---
M
V
L
S
T
L
A
Y
H
L
A
I
A
GY
P
D
N
A
L
E
--
I
F
N
I
A
F
D
T
I
I
G
A
E
T
S
Y
T
H
K
V
D
---
G
I
L
R
I
G
D
L
L
E
K
A
G
D
T
L
P
S
N
E
A
M
D
F
Y
K
M
A
F
D
I
F
D
K
L
H
V
N
Q
R
A
A
I
V
E
K
K
I
E
L
A
K
T
V
-------
Y
-------
D
VGL
P
Q
--
I
R
A
A
L
L
K
GK
N
H
Y
A
L
A
I
I
K
K
--
K
Y
S
G
V
M
R
L
I
G
E
L
E
V
A
L
W
M
K
R
V
N
-
N
M
E
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------
V
V
D
K
A
F
E
C
C
E
S
P
R
F
T
D
V
N
V
-----
Q
H
I
A
R
L
L
T
E
L
G
N
L
R
R
------------
A
----
L
------------
K
------
F
A
K
E
-----------
I
Q
N
I
--
H
K
R
S
E
A
L
K
A
I
A
L
E
L
V
R
R
K
K
-
F
E
E
V
K
K
I
I
E
S
I
P
D
P
K
I
R
E
E
A
L
N
E
I
GTIE--------------------
8
PsiBlast_PDB
53.70
27%
-163
- C1 -
4U15
1
ACM3_RAT
A:
[21-140]
-----------------------------------------------
F
L
A
L
-----------
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
-
L
S
L
A
C
A
D
L
I
I
-
G
V
I
-
S
M
N
L
F
T
T
Y
I
-
I
M
N
R
W
A
L
G
N
L
A
---
C
--
D
L
W
L
S
I
D
Y
V
A
---
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
--
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
E
C
F
I
Q
F
L
S
E
P
T
I
-------
T
-------
F
---
G
T
--
A
I
A
A
F
Y
-----
M
P
V
T
I
M
T
I
--
L
Y
W
---
R
I
Y
K
E
T
E
K
M
N
I
F
E
M
L
R
-
I
D
E
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----------------
S
G
G
D
E
A
E
K
L
F
N
-
Q
D
V
D
A
A
V
-----
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
------------
L
----
D
------------
A
------
V
R
R
A
-----------
A
L
I
N
--
M
V
F
Q
--
M
G
E
T
G
V
A
G
F
T
N
S
L
-
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
-----------------------------
6
PsiBlast_PDB
53.59
27%
-169
- C1 -
4DAJ
2
ACM3_RAT (first)
A:
[21-140]
-----------------------------------------------
F
L
A
L
-----------
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
-
L
S
L
A
C
A
D
L
I
I
-
G
V
I
-
S
M
N
L
F
T
T
Y
I
-
I
M
N
R
W
A
L
G
N
L
A
---
C
--
D
L
W
L
S
I
D
Y
V
A
---
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
--
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
E
C
F
I
Q
F
L
S
E
P
T
I
-------
T
-------
F
---
G
T
--
A
I
A
A
F
Y
-----
M
P
V
T
I
M
T
I
--
L
Y
W
---
R
I
Y
K
E
T
E
K
M
N
I
F
E
M
L
R
-
I
D
E
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------
L
K
I
Y
K
D
T
E
G
Y
Y
-
T
I
G
I
G
H
L
-----
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
------------
K
----
A
------------
I
------
G
R
N
T
-----------
N
G
V
I
--
T
K
D
E
--
A
E
K
L
F
N
Q
D
V
D
A
A
V
-
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
-----------------------------
7
PsiBlast_PDB
52.39
27%
-171
- C1 -
4U14
1
ENLYS_BPT4
A:
[21-140]
-----------------------------------------------
F
L
A
L
-----------
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
-
L
S
L
A
C
A
D
L
I
I
-
G
V
I
-
S
M
N
L
F
T
T
Y
I
-
I
M
N
R
W
A
L
G
N
L
A
---
C
--
D
L
W
L
S
I
D
Y
V
A
---
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
--
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
E
C
F
I
Q
F
L
S
E
P
T
I
-------
T
-------
F
---
G
T
--
A
I
A
A
F
Y
-----
M
P
V
T
I
M
T
I
--
L
Y
W
---
R
I
Y
K
E
T
E
K
M
N
C
F
E
M
L
R
-
I
D
E
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------
L
K
I
Y
K
D
C
E
G
Y
Y
-
T
I
G
I
G
H
L
-----
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
------------
K
----
A
------------
I
------
G
R
N
T
-----------
N
G
V
I
--
T
K
D
E
--
A
E
K
L
F
N
Q
D
V
D
A
A
V
-
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
-----------------------------
43
Fugue
52.18
12%
-150
- C1 -
1FJ2
13
LYPA1_HUMAN
A:
[3-231]
--------
M
D
P
E
F
M
S
T
P
L
P
A
I
V
------
P
----
A
----
A
R
K
A
T
A
A
V
I
F
L
H
G
L
G
---------
D
T
-------------
G
H
G
W
A
E
A
F
A
G
I
R
---
S
S
H
I
K
Y
I
C
P
H
---
A
P
----------
V
R
-
P
V
T
L
N
M
---
N
V
A
M
P
S
W
F
D
I
I
G
L
---
S
P
D
S
Q
--
E
D
E
S
G
I
K
Q
A
A
E
N
I
K
A
L
I
D
Q
E
V
---
K
N
G
I
P
S
N
R
I
I
L
G
G
F
S
Q
G
G
A
L
S
L
Y
T
A
L
-
T
T
Q
Q
K
L
A
G
----------------------------------------------------------------------
V
T
A
L
S
C
W
L
P
L
R
A
S
F
P
-
Q
G
P
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----------------
A
N
R
D
----------
I
S
I
L
Q
-----
C
H
G
D
C
D
P
L
V
P
L
M
F
G
S
------------
L
----
T
------------
V
------
E
K
L
K
-----------
T
L
V
N
--
P
A
N
V
--
T
F
K
T
Y
E
G
M
M
H
S
S
--
C
Q
Q
E
M
M
D
V
K
Q
F
I
D
K
L
L
P
P
I
-----------------------------
15
PsiBlast_PDB
51.98
24%
-166
- C1 -
4S0V
1
OX2R_HUMAN
A:
[58-187]
--------------------------------------
E
Y
E
W
V
L
I
A
G
Y
I
I
V
F
V
---------
V
A
L
I
G
N
V
L
V
C
V
A
V
W
K
N
H
H
M
R
T
V
T
N
Y
F
I
-
V
N
L
S
L
A
D
V
L
V
T
I
T
C
-
L
P
---
A
T
L
V
-
V
D
I
T
-
E
T
W
F
F
G
Q
S
L
C
K
V
I
P
Y
L
Q
T
V
S
V
S
---
V
S
V
L
T
--
L
S
C
I
A
L
D
R
W
Y
A
I
C
H
P
----
S
T
---
A
K
R
A
R
N
S
I
V
I
I
----
W
I
V
S
C
I
I
M
I
P
Q
A
I
V
M
E
C
S
T
V
F
K
T
T
L
F
T
V
C
D
E
R
W
G
G
E
I
Y
P
-------
K
-------
M
---
Y
H
--
I
C
F
F
L
V
-----
T
Y
M
A
P
L
C
L
--
M
V
L
---
A
Y
L
Q
I
F
R
K
L
W
C
R
Q
G
I
D
-
C
S
F
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------
S
Y
L
T
G
S
R
D
E
R
K
-
K
S
L
L
S
K
F
-----
G
M
D
E
G
V
T
F
M
F
I
G
R
F
D
------------
R
----
G
------------
Q
------
K
G
V
D
-----------
V
L
L
K
--
A
I
E
I
--
L
S
S
K
K
E
F
Q
E
M
R
F
I
-
I
I
G
K
G
D
P
E
L
E
G
W
A
R
S
L
E
E
K
-----------------------------