@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TA2R9_HUMAN: (2016-01-15 )
MPSAIEAIYIILIAGELTIGIWGNGFIVLVNCIDWLKRRDISLIDIILISLAISRICLLCVISLDGFFMLLFPGTYGNSVLVSIVNVVWTFANNSSLWFTSCLSIFYLLKIANISHPFFFWLKLKINKVMLAILLGSFLISLIISVPKNDDMWYHLFKVSHEENITWKFKVSKIPGTFKQLTLNLGVMVPFILCLISFFLLLFSLVRHTKQIRLHATGFRDPSTEAHMRAIKAVIIFLLLLIVYYPVFLVMTSSALIPQGKLVLMIGDIVTVIFPSSHSFILIMGNSKLREAFLKMLRFVKCFLRRRKPFVP
Atome Classification :
(20 SA)
---------------........----.10....----....20-----.......-------.30....--...--.40-------------------------........--50.....-...--------60.-....--...------70-........80...-..-------.-------..90------------...--.-.....100.---...----------...110--.------.......120------.---......130.......140........150.......160------..------.....-------..170.-----.-----.-....180----------........190-----........------.200.......210.------.-...------------------------------------------------------------------------------------------------------------------------------------------------------.----------------------------------------------------------------------------------------------------------------------------------------------------.-220...--....230...----....----240....-----...250..-----..-.-.-------------.-------260..--.....270-----....---------...280---------------......-..290------------.-------.......300.-..-....310------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------MPSA
I
E
A
I
----
Y
I
I
L
I
AG----
E
L
T
I
G
I
-----WGN
G
F
I
V
-------
L
V
N
C
I
D
W
--
L
K
R--RD
I
-------------------------
S
L
I
D
I
I
L
I
--
S
L
A
I
S
R
I
-
C
L
L
--------
C
V
I-SLD
G
--
F
F
M
------
L
L
-FPGTYG
N
S
V
L
V
S
I
-
V
N
-------
V
-------
V
WT-------------FAN--N-SS
L
W
F
T
S
C
L
---
S
I
F
----------
Y
L
L
K
I
---A------NISH
P
F
F
F
W
L
------
K
---
L
K
I
N
K
V
M
L
A
I
L
L
G
S
F
L
I
-
S
L
I
I
SVPKNDD
M
W
Y
H
L
F
K
VS--------HE------E
N
I
T
W
-------
K
F
K
VSK-----I-----P-G
T
F
K
Q
L
-----------
T
LNL
G
V
M
V
P
-------
F
I
L
C
L
I
S
F
------
F
L
L
L
F
S
L
V
R
H
T
K
Q
I
R
------
L
-
H
AT------------------------------------------------------------------------------------------------------------------------------------------------------G----------------------------------------------------------------------------------------------------------------------------------------------------F-RDP
S
T
E
--
A
H
M
R
A
I
K
A
V
I
----
I
F
L
L
----
L
L
I
V
Y
Y
P
-----
V
F
L
V
MTSS-----AL-I-P-------------Q-------
G
K
L
V
L
--
M
IG
D
I
V
T
V
-----
I
FPS---------SH
S
F
I
----------------
L
I
MGN
S
-
K
L
R
E
-------------
A
-------
F
L
K
M
L
R
F
V
K
C
F
-
L
R
-RRKPFVP------------------------------------------------
28
HHSearch
81.64
17%
-138
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[38-322]
-------------------
N
K
Y
V
----
V
I
I
A
Y
A
L
----
V
F
L
L
S
L
-----
L
G
N
S
L
V
M
-------
L
V
I
L
Y
-----
S
R
--
V
G
R
-------------------------
S
V
T
D
V
Y
L
L
--
N
L
A
L
A
D
L
-
L
F
A
--------
L
T
--
L
P
I
W
--
A
A
S
------
K
--
V
N
G
W
I
F
G
T
F
L
C
K
V
-
V
S
-------
L
-------
L
K
E
-------------
V
N
F
--
Y
-
S
G
I
L
L
L
A
C
I
---
S
V
D
----------
R
Y
L
A
I
------------
V
H
A
T
-
R
T
L
------
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
-
S
M
N
L
S
L
P
F
F
L
F
R
Q
-
A
--
Y
H
P
--------
N
N
------
S
S
P
V
C
-------
Y
E
V
L
G
N
-----
D
TAKW-
R
-
M
V
L
R
I
L
-----------
P
H
T
F
G
F
I
V
P
-------
L
F
V
M
L
F
C
Y
------
G
F
T
L
R
T
L
F
K
A
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
--
Q
K
H
R
A
M
R
V
I
F
----
A
V
V
L
----
I
F
L
L
C
W
L
-----
P
Y
N
L
V
L
L
A
-----
D
T
-
L
M
R
TQVIQE
S
C
E
R
R
N
-
N
-------
I
G
R
A
L
--
D
A
T
E
I
L
G
F
-----
L
H
S
C
---------
L
N
P
I
I
----------------
Y
A
F
I
G
Q
-
N
F
R
H
-------------
G
-------
F
L
K
I
L
A
M
H
G
-------------------------------------------------------------
17
HHSearch
76.20
14%
-141
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[47-497]
-------------------
N
K
I
F
----
L
P
T
I
Y
S
I
----
I
F
L
T
G
I
-----
V
G
N
G
L
V
I
-------
L
V
M
---
G
--
Y
Q
K
--
K
L
R
-------------------------
S
M
T
D
K
Y
R
L
--
H
L
S
V
A
D
L
-
L
F
V
--------
I
-
T
-
L
P
F
W
--
A
V
D
------
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
-
V
H
-------
V
-------
I
Y
T
-------------
V
N
L
--
Y
-
S
S
V
W
I
L
A
F
I
---
S
L
D
----------
R
Y
L
A
I
------------
V
H
A
T
-
N
S
Q
------
R
---
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
-
A
L
L
L
T
I
P
D
F
I
F
A
N
----
V
S
E
--------
A
D
------
D
R
Y
I
C
-------
D
R
F
Y
P
N
-----
D
L
W
---
V
-
V
V
F
Q
F
Q
-----------
H
I
M
V
G
L
I
L
P
-------
G
I
V
I
L
S
C
Y
------
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
------
E
-
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
----------------------------------------------------------------------------------------------------------------------------------------------------
A
-
Y
G
S
K
G
H
--
Q
K
R
K
A
L
K
T
T
V
----
I
L
I
L
----
A
F
F
A
C
W
L
-----
P
Y
Y
I
G
I
S
I
-----
D
S
-
F
-
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
-------
V
H
K
W
I
--
S
I
T
E
A
L
A
F
-----
F
H
C
C
---------
L
N
P
I
L
----------------
Y
A
F
L
G
A
-
K
F
K
T
-------------
S
-------
A
Q
H
A
L
T
S
G
R
P
L
-
E
V
-
L
F
Q
----------------------------------------------------
23
HHSearch
75.96
15%
-129
- C4 -
2Z73
5
OPSD_TODPA
A:
[32-335]
------------------
A
V
Y
Y
S
----
L
G
I
F
I
G
I
----
C
G
I
I
G
C
-----
G
G
N
G
I
V
I
-------
Y
L
F
T
K
-----
T
K
--
S
L
Q
-------------------------
T
P
A
N
M
F
I
I
--
N
L
A
F
S
D
F
-
T
F
S
--------
L
V
N
G
F
P
L
M
--
T
I
S
------
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
-
Y
G
-------
F
-------
I
G
G
-------------
I
F
G
--
F
-
M
S
I
M
T
M
A
M
I
---
S
I
D
----------
R
Y
N
V
I
------------
G
R
P
M
-
A
A
S
------
K
---
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
-
S
V
L
W
A
I
G
P
I
F
G
W
G
-
A
--
Y
T
L
--------
E
G
------
V
L
C
N
C
-------
S
F
D
Y
I
S
RD
S
--
T
-----
T
-
R
S
N
I
L
C
-----------
M
F
I
L
G
F
F
G
P
-------
I
L
I
I
F
F
C
Y
------
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
------
A
-
M
A
K
RLNAKE
L
-----------------------------------------------------------------------------------------------------------------------------------------------
R
----------------------------------------------------------------------------------------------------------------------------------------------------
K
-
A
Q
A
G
A
N
--
A
E
M
R
L
A
K
I
S
I
----
V
I
V
S
----
Q
F
L
L
S
W
S
-----
P
Y
A
V
V
A
L
L
-----
A
Q
-
F
-
G
PLEW---------
V
-------
T
P
Y
A
A
--
Q
L
P
V
M
F
A
K
-----
A
S
A
I
---------
H
N
P
M
I
----------------
Y
S
V
S
H
P
-
K
F
R
E
-------------
A
-------
I
S
Q
T
F
P
W
V
L
T
C
-
C
Q
-
F
D
D
K
E
T
E
------------------------------------------------
25
HHSearch
74.04
11%
-135
- C4 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
----------------------
L
----
W
A
A
A
Y
T
V
----
I
V
V
T
S
V
-----
V
G
N
V
V
V
M
-------
W
I
I
---
L
--
A
H
K
--
R
M
R
-------------------------
T
V
T
N
Y
F
L
V
--
N
L
A
F
A
E
A
-
S
M
A
--------
A
F
N
-
T
V
V
N
--
F
T
Y
------
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
-
H
N
-------
F
-------
F
P
I
-------------
A
A
V
--
F
-
A
S
I
Y
S
M
T
A
V
---
A
F
D
----------
R
Y
M
A
I
------------
I
H
P
L
-
Q
P
R
------
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
-
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
----
T
E
T
--------
M
P
------
S
R
V
V
C
-------
M
I
E
W
P
E
-----
H
PNKIY
E
-
K
V
Y
H
I
C
-----------
V
T
V
L
I
Y
F
L
P
-------
L
L
V
I
G
Y
A
Y
------
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
------
S
-
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
----------------------------------------------------------------------------------------------------------------------------------------------------
R
-
Y
H
E
Q
V
S
--
A
K
R
K
V
V
K
M
M
I
----
V
V
V
C
----
T
F
A
I
C
W
L
-----
P
F
H
I
F
F
L
L
-----
P
Y
-
I
-
N
-------------
P
DLYLKKF
I
Q
Q
V
Y
--
L
A
I
M
W
L
A
M
-----
S
S
T
M
---------
Y
N
P
I
I
----------------
Y
C
C
L
N
D
-
R
F
R
L
-------------
G
-------
F
K
H
A
F
R
C
C
P
F
I
-
S
A
-
G
D
Y
E
G
L
E
------------------------------------------------
42
Fugue
72.23
20%
-163
- C1 -
4L8N
3
?
A:
[6-457]
---------------
N
T
S
I
C
R
L
G
----
F
T
Y
D
I
S
Q
----
S
K
N
--------
W
G
N
N
K
P
V
-------
I
K
S
I
I
P
Y
S
S
A
E
Q
--
A
G
I
-------------------------
K
K
Y
D
V
I
E
E
IN
G
V
P
V
T
E
V
----------------
S
V
D
E
--
I
P
Q
------
L
L
-
N
P
A
G
R
-
N
D
V
L
L
T
I
-
S
N
LSSP
S
K
Q
V
-------
L
V
K
K
D
C
K
K
SNAIT
E
D
Q
L
A
S
A
Y
A
M
Y
S
L
E
T
T
N
E
Q
---
E
F
V
----------
C
P
F
K
T
---
T
V
T
SDGV
D
F
G
N
F
K
T
F
A
F
S
T
IDEN
N
---
R
K
L
E
T
V
I
N
E
C
I
E
N
E
L
T
K
K
G
L
T
V
D
I
A
K
P
D
L
L
I
Q
T
F
Y
F
F
D
K
N
PNYLGA
N
E
------
K
E
P
T
Y
-------
R
Y
N
F
S
H
-----
S
-----
K
M
E
K
F
P
F
L
NY
A
A
A
E
A
E
AE
Y
L
L
Q
F
G
I
R
I
I
D
QKDIPG
R
V
L
W
E
C
E
A
------
N
E
L
L
E
D
S
Y
R
L
D
E
Y
A
R
------
V
-
H
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------
C
M
Q
Y
P
Y
T
K
YG
R
N
V
P
F
K
V
S
K
K
----
T
Y
N
Y
----
T
G
I
S
Y
D
I
DKLDQ
V
V
D
V
D
R
N
S
-----
P
A
-
Y
-
A
-------------
A
-------
G
---
I
--
R
P
R
D
I
I
E
K
-----
I
G
R
H
KMDHS
A
E
E
F
S
S
A
Y
K
----------------
R
F
I
T
N
T
M
Q
Y
R
D
PKT
M
F
T
D
ANGFK
Y
C
M
------
F
W
D
V
F
K
Y
P
Q
I
A
-
D
A
S
Q
S
S
D
Y
L
P
AFSYLYYFAPYINPSGNN
A
C
T
F
N
I
K
R
GK
T
K
L
E
V
I
I
R
P
T
I
R
S
E
V
T
V
E
IK
26
HHSearch
69.97
12%
-133
- C4 -
1U19
14
OPSD_BOVIN
A:
[41-328]
---------------------
S
M
----
L
A
A
Y
M
F
L
----
L
I
M
L
G
F
-----
P
I
N
F
L
T
L
-------
Y
V
T
---
V
--
Q
H
K
--
K
L
R
-------------------------
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
-
F
M
V
--------
F
G
G
-
F
T
T
T
--
L
Y
T
------
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
-------
F
-------
F
A
T
-------------
L
G
G
--
E
-
I
A
L
W
S
L
V
V
L
---
A
I
E
----------
R
Y
V
V
V
------------
C
K
P
M
-
S
N
F
------
R
---
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
-
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
--
Y
I
P
--------
E
G
------
M
Q
C
S
C
-------
G
I
D
Y
Y
T
PHEET
N
-----
N
-
E
S
F
V
I
Y
-----------
M
F
V
V
H
F
I
I
P
-------
L
I
V
I
F
F
C
Y
------
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
Q
K
--
A
E
K
E
V
T
R
M
V
I
----
I
M
V
I
----
A
F
L
I
C
W
L
-----
P
Y
A
G
V
A
F
Y
-----
I
F
-
T
-
H
QGSD---------
F
-------
G
P
I
F
M
--
T
I
P
A
F
F
A
K
-----
T
S
A
V
---------
Y
N
P
V
I
----------------
Y
I
M
M
N
K
-
Q
F
R
N
-------------
C
-------
M
V
T
T
L
C
C
G
K
N
P
-
L
G
-
D
D
E
A
S
T
T
------------------------------------------------
41
Fugue
69.90
22%
-168
- C6 -
4Q6O
8
?
A:
[21-437]
-----------MIEK
A
P
T
N
V
E
D
R
DK
A
P
H
L
L
L
L
A
G
IQGD
E
P
G
G
F
N
-----
A
T
N
L
F
L
M
HYSVL
K
G
L
V
E
V
V
P
V
--
L
N
K
--
P
S
M
L
R
NHRGLYGDMNRKFAALDKNDPE
Y
P
T
I
Q
E
I
K
S
--
L
I
A
K
P
S
I
D
A
V
L
--------
H
L
H
-
D
G
G
G
--
Y
Y
R
PVYVDA
M
L
-
N
P
K
R
W
G
N
C
F
I
I
D
Q
-
D
E
-------
V
KGAKFPN
L
L
A
-------------
F
A
N
--
N
-
T
I
E
S
I
N
A
H
L
LHP
I
E
E
----------
Y
H
L
K
N
---
T
------
R
T
A
Q
G
D
T
-
E
M
------
Q
---
K
A
L
T
F
Y
A
I
N
Q
K
K
S
A
F
A
N
-
E
A
S
K
E
L
P
L
A
S
R
V
F
Y
H
L
Q
A
I
E
G
L
L
-----
N
Q
------
L
N
I
P
F
-------
K
R
D
F
D
L
-----
N
-----
P
-
N
S
V
H
A
L
I
N
---------
D
K
N
L
W
A
K
I
S
-------
S
L
P
-----------
K
M
P
L
F
N
L
R
P
K
L
N
H
F
P
------
L
P
H
N
T
------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------------------------------------------------------------------------------------------------------------------------------------------
I
-
P
Q
I
P
I
E
--
S
N
A
Y
I
V
G
L
V
K
N
KQ
E
V
F
L
K
YGNK
L
M
T
R
L
S
P
-----
F
Y
I
E
F
D
P
S
LE
E
V
K
M
Q
-
I
-
D
-------------
N
-------
K
D
Q
M
V
--
K
I
G
S
V
V
E
V
K
E
S
F
Y
I
H
A
M
---------
D
N
I
R
A
----------------
N
V
I
G
F
S
-
V
S
N
E
-------------
N
KPNEAGY
T
I
K
F
K
D
F
Q
K
R
F
S
L
D
-
K
Q
E
R
I
Y
R
I
E
F
Y
KNNAFS
G
M
I
L
V
K
F
V------------------------------
27
HHSearch
69.36
12%
-143
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------
Y
A
L
S
Y
C
A
----
L
I
L
A
I
V
-----
F
G
N
G
L
V
C
-------
M
A
V
---
L
--
K
E
R
--
A
L
Q
-------------------------
T
T
T
N
Y
L
V
V
--
S
L
A
V
A
D
L
-
L
V
A
--------
T
L
V
-
M
P
W
V
--
V
Y
L
------
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
-
F
V
-------
T
-------
L
D
V
-------------
M
M
C
--
T
-
A
S
I
W
N
L
C
A
I
---
S
I
D
----------
R
Y
T
A
V
------------
V
M
P
V
-
H
Y
Q
------
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
-
A
F
A
V
S
C
P
L
L
F
G
F
N
-
T
---
T
----------
G
------
D
P
T
V
C
-------
S
I
S
N
P
---------------
D
F
V
I
Y
-----------
S
S
V
V
S
F
Y
L
P
-------
F
G
V
T
V
L
V
Y
------
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
------
F
-
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
-----------------
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW-----------------------------------------------------------------------------------------------------------------------------------
D
-
A
Y
G
V
P
L
--
R
E
K
K
A
T
Q
M
V
A
----
I
V
L
G
----
A
F
I
V
C
W
L
-----
P
F
F
L
T
H
V
L
-----
N
T
-
H
C
Q
TCH----------
V
-------
S
P
E
L
Y
--
S
A
T
T
W
L
G
Y
-----
V
N
S
A
---------
L
N
P
V
I
----------------
Y
T
T
F
N
I
-
E
F
R
K
-------------
A
-------
F
L
K
I
L
S
C
---------------------------------------------------------------
16
HHSearch
67.39
12%
-129
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
----------------------
F
----
I
V
L
V
A
G
S
----
L
S
L
V
T
I
-----
I
G
N
I
L
V
M
-------
V
S
I
---
K
--
V
N
R
--
H
L
Q
-------------------------
T
V
N
N
Y
F
L
F
--
S
L
A
C
A
D
L
-
I
I
G
--------
V
F
S
-
M
N
L
Y
--
T
L
Y
------
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
-
W
L
-------
A
-------
L
D
Y
-------------
V
V
S
--
N
-
A
S
V
M
N
L
L
I
I
---
S
F
D
----------
R
Y
F
C
V
------------
T
K
P
L
-
T
Y
P
------
V
---
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
-
S
F
I
L
W
A
P
A
I
L
F
W
Q
-
F
I
-
V
G
V
R-------
T
V
------
E
D
G
E
C
-------
Y
I
Q
F
F
S
-----------
N
-
A
A
V
T
F
G
-----------
T
A
I
A
A
F
Y
L
P
-------
V
I
I
M
T
V
L
Y
------
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
------
M
-
L
R
I
------------------------------------------------------------------------------------------------------------------------------------------------------
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
-
A
Y
P
P
P
S
--
R
E
K
K
V
T
R
T
I
L
----
A
I
L
L
----
A
F
I
I
T
W
A
-----
P
Y
N
V
M
V
L
I
-----
N
T
-
F
-
C
APC----------
I
-------
P
N
T
V
W
--
T
I
G
Y
W
L
C
Y
-----
I
N
S
T
---------
I
N
P
A
C
----------------
Y
A
L
C
N
A
-
T
F
K
K
-------------
T
-------
F
K
H
L
L
M
----------------------------------------------------------------
18
HHSearch
67.13
13%
-147
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
---------------------
M
P
----
L
V
V
V
L
S
T
----
I
C
L
V
T
V
-----
G
L
N
L
L
V
L
-------
Y
A
V
---
R
--
S
E
R
--
K
L
H
-------------------------
T
V
G
N
L
Y
I
V
--
S
L
S
V
A
D
L
-
I
V
G
--------
A
V
V
-
M
P
M
N
--
I
L
Y
------
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
-
W
L
-------
S
-------
M
D
Y
-------------
V
A
S
--
T
-
A
S
I
F
S
V
F
I
L
---
C
I
D
----------
R
Y
R
S
V
------------
Q
Q
P
L
-
R
Y
L
------
K
---
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
-
S
F
L
W
V
I
P
I
L
G
W
N
H
----------------
R
------
R
E
D
K
C
-------
E
T
D
F
Y
D
-----
V
-------
T
W
F
K
V
M
-----------
T
A
I
I
N
F
Y
L
P
-------
T
L
L
M
L
W
F
Y
------
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
------
M
-
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW------------------------------------------------------------------------------------------------------------------------------------
D
-
A
Y
L
H
M
N
--
R
E
R
K
A
A
K
Q
L
G
----
F
I
M
A
----
A
F
I
L
C
W
I
-----
P
Y
F
I
F
F
M
V
-----
I
A
-
F
-
C
KNC----------
C
-------
N
E
H
L
H
--
M
F
T
I
W
L
G
Y
-----
I
N
S
T
---------
L
N
P
L
I
----------------
Y
P
L
C
N
E
-
N
F
K
K
-------------
T
-------
F
K
R
I
L
H
I
---------------------------------------------------------------
38
Fugue
67.02
16%
-160
- C3 -
4CIJ
-
?
A:
[3-269]
------------MS
G
L
K
P
C
V
D
W
L
----
Q
V
T
F
K
T
G
----
Q
D
S
V
K
----------------------
K
C
V
E
K
--
L
E
K
V
F
E
I
L
-------------------------
G
L
N
E
A
E
F
L
--
P
L
K
N
G
K
Y
-
G
Y
K
--------
Q
G
V
-
A
F
Q
G
NP
V
L
A
------
V
Y
-
Y
D
G
A
D
D
M
G
I
H
V
E
M
T
G
Q
-------
G
-------
C
R
L
-------------
F
E
L
--
H
-
T
S
I
N
W
Y
E
L
F
---
Y
R
L
----------
V
Y
-------------------
E
Y
E
V
------
N
---
I
T
R
L
D
V
A
V
D
D
F
K
G
Y
F
K
I
-
N
T
L
V
K
K
L
K
D
D
E
V
T
S
R
F
K
K
A
R
--------
H
I
------
E
N
I
V
I
-------
E
----------------
G
-
G
E
T
I
G
H
-----------
T
L
Y
F
G
A
--
P
-------
S
S
D
I
Q
V
R
F
------
Y
E
---------
K
N
V
Q
------
M
-
G
M
D
------------------------------------------------------------------------------------------------------------------------------------------------------
I
----------------------------------------------------------------------------------------------------------------------------------------------------
D
-
V
W
N
R
T
E
--
I
Q
L
R
D
D
R
A
H
V
----
V
A
Q
I
----
I
A
D
D
V
L
P
-----------------------------------------------------
L
G
E
I
V
A
G
-----
L
L
R
N
---------
Y
I
Q
F
R
----------------
T
R
K
A
T
D
-
K
N
K
K
-------------
R
-------
W
-
P
L
A
R
F
W
L
N
F
-
L
G
-
D
V
Q
P
L
R
I
AKQM--------------------------------------------
20
HHSearch
66.57
13%
-137
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
---------------------
V
G
----
M
G
I
V
M
S
L
----
I
V
L
A
I
V
-----
F
G
N
V
L
V
I
-------
T
A
I
---
A
--
K
F
E
--
R
L
Q
-------------------------
T
V
T
N
Y
F
I
T
--
S
L
A
C
A
D
L
-
V
M
G
--------
L
A
V
-
V
P
F
G
--
A
A
H
------
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
-------
S
-------
I
D
V
-------------
L
C
V
--
T
-
A
S
I
E
T
L
C
V
I
---
A
V
D
----------
R
Y
F
A
I
------------
T
S
P
F
-
K
Y
Q
------
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
-
S
G
L
T
S
F
L
P
I
Q
M
H
W
-
Y
R
-
A
T
H
--------
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------
D
F
F
--------
T
-----
N
-
Q
A
Y
A
I
A
-----------
S
S
I
V
S
F
Y
V
P
-------
L
V
I
M
V
F
V
Y
------
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
------
M
-
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT--
W
----------------------------------------------------------------------------------------------------------------------------------------------------
D
-
A
Y
K
F
C
L
--
K
E
H
K
A
L
K
T
L
G
----
I
I
M
G
----
T
F
T
L
C
W
L
-----
P
F
F
I
V
N
I
V
-----
H
V
-
I
-
Q
DNL----------
I
-------
R
K
E
V
Y
--
I
L
L
N
W
I
G
Y
-----
V
N
S
G
---------
F
N
P
L
I
----------------
Y
C
-
R
S
P
-
D
F
R
I
-------------
A
-------
F
Q
E
L
L
C
L
---------------------------------------------------------------
44
Fugue
66.36
11%
-161
- C5 -
1VD5
4
UGL_BACGL
A:
[1-377]
MW
Q
Q
A
I
G
D
A
L
G
I
T
A
R
N
L
K
K
F
G
D
R
----
F
P
H
V
S
D
G
----
S
N
K
Y
V
L
N
DNTD
W
T
D
G
F
W
S
-------
G
I
L
W
L
C
Y
--
E
Y
T
--
G
D
E
-------------------------
Q
Y
R
E
G
A
V
R
--
T
V
A
S
F
R
E
-
R
L
D
R
FENLDHH
D
I
G
-
F
L
Y
S
--
L
S
A
------
K
A
-
Q
W
I
V
E
K
D
E
S
A
R
K
L
-
A
L
-------
D
-------
A
A
D
-------------
V
L
M
--
R
-
R
W
R
A
D
A
G
I
I
---
Q
A
W
GPKGDPENGG
R
I
I
I
D
---
C
------
L
L
N
L
P
L
L
L
W
A
------
G
---
E
Q
T
G
D
P
E
Y
R
R
V
A
E
A
H
A
L
-
K
S
R
R
F
L
V
R
G
D
D
S
S
Y
H
T
F
Y
F
D
--------
P
E
------
N
G
N
A
I
-------
R
G
G
T
H
Q
-----
G
-----
N
-
T
D
G
S
T
W
-----------
T
R
G
Q
A
W
G
I
Y
-------
G
F
A
L
N
S
R
Y
L
GN
A
D
L
L
E
T
A
K
R
M
A
R
H
F
L
A
R
V
PEDGVV
Y
-
W
D
F
------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------------------------------------------------------------
V
-
P
Q
E
P
S
S
--
Y
R
D
S
S
A
S
A
I
T
----
A
C
G
L
----
L
E
I
A
S
Q
L
-----
D
E
S
D
P
E
R
Q
-----
R
F
-
I
-
D
-------------
A
-------
A
K
T
T
V
T
A
L
R
D
G
Y
A
E
R
-----
D
D
G
E
---------
A
E
G
F
I
RRGSYHVRGGISP
D
D
Y
T
I
W
G
D
Y
-
Y
Y
L
E
-------------
A
-------
L
L
R
L
E
R
G
V
T
G
Y
-
W
Y
-
E
R
G
R
---------------------------------------------------
22
HHSearch
64.12
14%
-132
- C4 -
3EML
13
ENLYS_BPT4
A:
[22-472]
---------------------
S
V
----
Y
I
T
V
E
L
A
----
I
A
V
L
A
I
-----
L
G
N
V
L
V
C
-------
W
A
V
---
W
--
L
N
S
--
N
L
Q
-------------------------
N
V
T
N
Y
F
V
V
--
S
L
A
A
A
D
I
-
A
V
G
--------
V
L
A
-
I
P
F
A
--
I
T
I
------
S
T
---
G
F
C
A
A
C
H
G
C
L
F
-
I
A
-------
C
-------
F
V
L
-------------
V
L
T
--
Q
-
S
S
I
F
S
L
L
A
I
---
A
I
D
----------
R
Y
I
A
I
------------
R
I
P
L
-
R
Y
N
------
G
---
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
-
N
--
C
G
Q
-----------------
S
Q
G
C
GEGQVAC
L
F
E
D
V
V
-----
P
-----
M
-
N
Y
M
V
Y
F
-----------
N
F
F
A
C
V
L
V
P
-------
L
L
L
M
L
G
V
Y
------
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
------
M
-
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW-
D
----------------------------------------------------------------------------------------------------------------------------------------------------
A
-
Y
R
S
T
L
Q
--
K
E
V
H
A
A
K
S
L
A
----
I
I
V
G
----
L
F
A
L
C
W
L
-----
P
L
H
I
I
N
C
F
-----
T
F
F
C
-
P
DCSH---------
A
-------
P
L
W
L
M
--
Y
L
A
I
V
L
S
H
-----
T
N
S
V
---------
V
N
P
F
I
----------------
Y
A
Y
R
I
R
-
E
F
R
Q
-------------
T
-------
F
R
K
I
I
R
S
H
V
L
R
-
Q
---------------------------------------------------------
24
HHSearch
63.36
11%
-122
- C4 -
3V2Y
1
ENLYS_BPT4
A:
[62-495]
-------------------
S
I
K
L
----
T
S
V
V
F
I
L
----
I
C
C
F
I
I
-----
L
E
N
I
F
V
L
-------
L
T
I
---
W
--
K
T
K
--
K
F
H
-------------------------
R
P
M
Y
Y
F
I
G
--
N
L
A
L
S
D
L
-
L
A
G
--------
V
A
Y
-
T
A
N
L
--
L
L
S
------
G
A
--
T
T
Y
K
L
T
P
A
Q
W
F
L
-
R
E
-------
G
-------
S
M
F
-------------
V
A
L
--
S
-
A
S
V
F
S
L
L
A
I
---
A
I
E
----------
R
Y
I
T
M
------------
L
K
------------------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
-
S
L
I
L
G
G
L
P
I
M
G
W
N
-
C
---
I
----------
S
------
A
L
S
S
C
-------
S
T
V
L
P
L
-----
Y
-----
H
-
K
-
H
Y
I
L
-----------
F
C
T
T
V
F
T
L
L
-------
L
L
S
I
V
I
L
Y
------
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
------
L
-
R
I
D
EGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
----------------------------------------------------------------------------------------------------------------------------------------------------
A
-
Y
A
S
R
S
S
--
E
N
V
A
L
L
K
T
V
I
----
I
V
L
S
----
V
F
I
A
C
W
A
-----
P
L
F
I
L
L
L
L
-----
D
V
-
G
-
C
-------------
K
VKTC
D
--
I
L
F
R
A
--
E
Y
F
L
V
L
A
V
-----
L
N
S
G
---------
T
N
P
I
I
----------------
Y
T
L
T
N
K
-
E
M
R
R
-------------
A
-------
F
I
R
I
M
G
R
P
L
-------------------------------------------------------------
35
Fugue
61.46
17%
-103
- C2 -
2XQH
4
?
A:
[23-280]
-----------------
S
D
A
K
A
----------
S
G
----
E
F
S
V
A
V
------
G
N
G
A
R
A
-------
T
E
K
A
------------------------------------------------
S
T
A
V
G
S
W
-
A
--------------
A
A
D
G
K-
Q
S
T
------
A
L
-
G
V
G
T
Y
A
Y
A
N
A
S
T
A
-
L
G
-------
S
-------
V
-
A
-------------
F
V
D
--
N
-
T
A
T
Y
G
T
A
A
G
---
N
R
A
----------
K
V
D
K
-----------
D
A
T
E
G
T
A
L
G
A
------
K
---
A
T
V
T
N
-
K
N
S
V
A
L
G
A
-------
N
S
V
T
T
R
D
N
E
V
Y
I
G
Y
K
T
G
--------
T
E
------
S
D
K
T
Y
-------
G
---
T
R
-----
V
-----
L
-
G
G
L
S
D
G
-----------
T
R
N
-
S
D
A
A
T
-------
V
G
Q
L
N
R
K
V
------
G
G
V
Y
D
D
V
K
A
R
I
T
V
E
S
------
E
-
K
Q
K
------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
T
D
Q
K
T
S
--
E
V
N
E
K
V
E
A
R
------------------------------
T
T
V
-----
G
V
-
D
-
S
-------------
D
-------
G
K
L
T
R
--
A
E
G
A
T
K
T
I
-----
A
V
N
D
---------
G
L
V
A
L
----------------
S
G
R
T
D
R
-
I
D
Y
A
-------------
V
-------
G
A
I
D
G
R
V
T
R
N
T
-
Q
S
-
I
E
K
N
S
K
A
I
A
A
N
T
RT-----------------------------------------
5
PsiBlast_PDB
58.47
26%
-155
- C4 -
3ODU
4
CXCR4_HUMAN (first)
A:
[62-180]
------------------------------------------
G
I
-----
V
G
N
G
L
V
I
-------
L
V
M
---
G
--
Y
Q
K
--
K
L
R
-------------------------
S
M
T
D
K
Y
R
L
--
H
L
S
V
A
D
---
L
L
--------
F
V
I
-
T
L
P
F
--
W
A
V
------
D
A
-
V
A
N
W
Y
F
G
N
F
L
C
K
A
-
V
H
-------
V
-------
I
Y
T
-------------
V
N
L
--
Y
-
S
S
V
W
I
L
A
F
I
---
S
L
D
----------
R
Y
L
A
I
V
HA
T
------
N
S
Q
R
P
----
R
------
K
---
L
L
A
E
K
V
---
V
Y
V
G
V
W
I
P
-
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
A
D
D
R
--------
Y
I
------
C
D
R
F
Y
-------
P
N
D
L
W
V
-----
V
-----
V
-
F
Q
F
Q
H
I
-----------
M
V
G
L
I
L
P
G
I
-------
V
I
L
S
C
Y
C
I
------
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
------
L
-
R
I
D
------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------------------------------------------------------------
G
-
L
R
L
K
I
Y
--
K
D
T
E
G
Y
Y
T
I
G
----
I
G
H
L
----
L
T
K
S
P
S
L
-----
N
A
A
K
S
E
L
D
-----
K
A
-
I
-
G
-------------
R
-------
N
T
N
G
V
--
I
T
K
D
E
A
E
K
-----
L
F
N
Q
---------
D
V
D
A
A
----------------
V
R
G
I
L
R
-
N
A
K
L
-------------
K
-------
P
V
Y
D
S
L
D
A
V
R
R
-
A
A
-
L
I
N
M
V
F
Q
------------------------------------------------
6
PsiBlast_PDB
57.08
26%
-159
- C4 -
3OE8
1
CXCR4_HUMAN (first)
A:
[62-180]
------------------------------------------
G
I
-----
V
G
N
G
L
V
I
-------
L
V
M
---
G
--
Y
Q
K
--
K
L
R
-------------------------
S
M
T
D
K
Y
R
L
--
H
L
S
V
A
D
---
L
L
--------
F
V
I
-
T
L
P
F
--
W
A
V
------
D
A
-
V
A
N
W
Y
F
G
N
F
L
C
K
A
-
V
H
-------
V
-------
I
Y
T
-------------
V
N
L
--
Y
-
S
S
V
W
I
L
A
F
I
---
S
L
D
----------
R
Y
L
A
I
V
HA
T
------
N
S
Q
R
P
----
R
------
K
---
L
L
A
E
K
V
---
V
Y
V
G
V
W
I
P
-
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
A
D
D
R
--------
Y
I
------
C
D
R
F
Y
-------
P
N
D
L
W
V
-----
V
-----
V
-
F
Q
F
Q
H
I
-----------
M
V
G
L
I
L
P
G
I
-------
V
I
L
S
C
Y
C
I
------
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
------
L
-
R
I
D
------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------------------------------------------------------------
G
-
L
R
L
K
I
Y
--
K
D
T
E
G
Y
Y
T
I
G
----
I
G
H
L
----
L
T
K
S
P
S
L
-----
N
A
A
K
S
E
L
D
-----
K
A
-
I
-
G
-------------
R
-------
N
T
N
G
V
--
I
T
K
D
E
A
E
K
-----
L
F
N
Q
---------
D
V
D
A
A
----------------
V
R
G
I
L
R
-
N
A
K
L
-------------
K
-------
P
V
Y
D
S
L
D
A
V
R
R
-
A
A
-
L
I
N
M
V
F
Q
------------------------------------------------
40
Fugue
56.84
16%
-152
* C6 *
3C5H
8
RHG35_HUMAN
A:
[11-255]
-----------RENL
Y
F
Q
G
T
Y
N
I
----
S
V
V
G
L
S
G
T---
E
K
E
K
G
Q
-----
C
G
I
G
-----------------------------------------------------------------
K
S
C
L
-
C
N
R
--------
F
V
R
-
P
S
A
D
--
E
F
H
------
L
D
-
H
T
S
V
L
S
T
S
D
F
G
G
R
-
V
--------------------------------
V
N
N
--
D
-
H
F
L
Y
W
G
E
V
S
---
K
M
H
----------
I
V
E
Q
T
---
E
------
F
I
D
D
Q
T
F
Q
P
H
------
R
---
S
T
A
L
Q
P
Y
I
K
R
A
A
A
T
K
L
A
-
S
------
A
E
K
L
M
Y
F
C
T
D
Q
L
G
--------
L
E
------
Q
D
-------------------------------
F
E
Q
K
-----------
Q
M
P
D
G
K
L
L
-------------
V
D
G
------
F
L
L
G
I
D
V
S
R
N
F
D
D
Q
L
------
K
-
F
V
S
------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------------------------------------------------------------------------------------------------------------------------------------------
L
-
Y
N
Q
L
A
K
--
T
K
----
K
P
I
V
----
V
V
L
T
----
K
-------------
C
D
E
G
V
E
-----
R
Y
-
I
-
R
-------------
D
-------
A
H
T
F
A
--
L
S
K
K
N
L
Q
V
-----
V
E
T
S
---------
A
R
S
----------------------
N
V
-
N
V
D
L
-------------
A
-------
F
S
T
L
V
Q
L
I
D
K
------------------------------------------------------------
4
PsiBlast_PDB
56.62
26%
-153
- C4 -
3OE6
4
CXCR4_HUMAN (first)
A:
[62-180]
------------------------------------------
G
I
-----
V
G
N
G
L
V
I
-------
L
V
M
---
G
--
Y
Q
K
--
K
L
R
-------------------------
S
M
T
D
K
Y
R
L
--
H
L
S
V
A
D
---
L
L
--------
F
V
I
-
T
L
P
F
--
W
A
V
------
D
A
-
V
A
N
W
Y
F
G
N
F
L
C
K
A
-
V
H
-------
V
-------
I
Y
T
-------------
V
N
L
--
Y
-
S
S
V
W
I
L
A
F
I
---
S
L
D
----------
R
Y
L
A
I
VHA
T
------
N
S
Q
R
P
----
R
------
K
---
L
L
A
E
K
V
---
V
Y
V
G
V
W
I
P
-
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
A
D
D
R
--------
Y
I
------
C
D
R
F
Y
-------
P
N
D
L
W
V
-----
V
-----
V
-
F
Q
F
Q
H
I
-----------
M
V
G
L
I
L
P
G
I
-------
V
I
L
S
C
Y
C
I
------
I
I
S
K
L
D
E
G
L
R
L
K
I
Y
K
------
D
-
T
E
G
------------------------------------------------------------------------------------------------------------------------------------------------------
Y
----------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
T
I
G
I
G
H
--
L
L
T
K
S
P
S
L
N
A
----
A
K
S
E
----
L
D
K
A
I
G
R
-----
N
T
N
G
V
I
T
K
-----
D
E
-
A
-
E
-------------
K
-------
L
F
N
Q
D
--
V
D
A
A
V
R
G
I
-----
L
R
N
A
---------
K
L
K
P
V
----------------
Y
D
S
L
D
A
-
V
R
R
A
-------------
A
-------
L
I
N
M
V
F
Q
M
G
E
T
-
G
V
-
A
G
F
S
L
R
M
------------------------------------------------