@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0124: (2015-11-28 )
MLLGIEKRGITNALWKLQEADQREVLTLTQRFELPEILARTLAIRGVNIENAGNFLYPLIRSLLPDPFHLLDMDKAVFRIIQAINNDENIAIFGDYDVDGATSSALISRYLRAIGIHSIIYIPDRVDEGYGLNSNALLQLKKKGIDLCISVDCGTLAYQPIEDAKGFGLDVIVIDHHLGTEKLPSAIAVVNPNRLDESSPYNSLAAVGVSFLLTVALNKSLREQDFFAGKKEPDLFDLLDLVALGTVCDVMQITGLNRAFVSQGLKVMSARKNVGLRVLFDALGILERPNVSRLSFNIGPCINAGGRIGEALLGARLLSTDDKKEADSIALKLIDLNNARKMMENEALLEAIIQVEKSTQSGANFIMVSGNWHQGVIGIIASRLKEKFHLPTIVISLNNRIGKASCRSIPGVDIGAAVLSAKCMNLIIEGGGHSMAAGFLINEDKMSDLHDFLTERFAYSTNDKALKVDGIVTAKAINLSLWNQLQRLEPFGVGNPEPRFIIQGAKIRKPEIVGVDHIKCFIVDDDVMVRAIAFRSANTHLGSAIMEGNIEAILGKISMNYWNGNEFVQFLIEDVLTIS
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10--------...---......-20..-......30........40.....-...-50.......--.60........-------------70........80......---..--90..---------------------------...--.-..100---....-.....110....-----------...120--..---..-------.-------.--.-----130...-..---..140.-------........150------.......-.160.......170---....---.....180...-....190.------....-..200.......210..-.....220.......230-........240.....-..250.....-..260.......-------270.....---..280....--...290.......300.......310......-------------------.320....-...330.......340--------.-........350..-.....360..-.---....370---.....-----....380....--...390--------.......400..-.....410--........420......-.430.......440.-......450-.........460--.......470.......480.......490.......500.......510....-...520.-------......530....-...540....-...550.......560..------.....570.......--------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLLGIEKRG
I
---------
T
N
A
---
L
W
K
LQE-AD
Q
R
-
E
V
L
T
L
T
Q
RFE
L
P
E
I
L
A
R
T
L
AIRG-VNI-ENAG
N
F
L
Y
P
--
L
I
R
S
LLPD
P
F
H
-------------
L
L
D
M
D
K
A
V
F
R
I
I
Q
A
INND---E
N
--
I
A
I
F
---------------------------GDY--D-VDG-----A
T
S
S
-
A
L
I
S
R
Y
L
R
A
IGI-----------
H
S
I
I
YI--PD---RV-------D-------E--G-----YGL
N
S
N
-
A
L
---
L
Q
L
--
K
-------KKG
I
D
L
C
I
SV-------DCGT
L
A
Y-QPIEDAKGF
G
L
D
-----
V
I
V
I
---DHHL
G
T
E
KLP
S
-
A
I
A
V
VNPN------RLDE-SSPY
N
S
L
A
A
V
G
V
S
F
L
L
T
-
V
A
LN
K
S
L
R
E
Q
D
FFAGKK--EP
D
L
F
D
L
L
D
L
V
A
L
G
T
V
-
C
D
V
M
Q
ITGL
N
-
R
A
F
V
S
Q
G
L
K
V
M
S
-------ARKNV
G
L
R
---
V
L
F
D
A
L
G
IL--ERPNV
S
R
L
S
FNIGPCINAG
G
R
I
G
E
A
L
L
G
A
RLL-------------------STDDKKE
A
-
D
S
I
A
L
K
L
I
DLN
N
A
R
----------
K
-
M
M
E
N
E
A
L
L
E
A
I
I
Q
-
V
EKSTQSGA
N
-
F
---
I
M
V
SG-----NWHQ
G
-----
V
I
G
I
I
A
S
R
L
K
E
--KFHL
P
T
--------
I
V
I
SLNNRIGKA-SCRSIPG---
V
D
I
G
A
A
V
L
S
A
K
C
M
N
L
I
I-EGGGH
S
M
A
A
G
F
L
IN
E
-
D
K
M
S
D
L
H
---
D
F
L
T
E
R
FAYSTN--D
K
A
L
K
VD
G
I
V
T
A
K
A
I
N
L
S
L
W
N
Q
L
Q
RLEPFGVGNPE
P
R
F
I
I
QGAKIRKP
E
I
V
G
V
D
-
H
I
K
C
F
I
V-------DD
D
V
M
V
R
A
I
A
FRS-ANTHL
G
S
A
I
M
-EG
N
I
E
A
I
L
G
K
I
S
M
N
YW
N
G
------
N
E
F
V
Q
F
L
I
E
D
V
LTIS--------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
98.73
29%
-102
- C4 -
2ZXR
1
RECJ_THET8
A:
[1-658]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
---------
D
R
V
---
R
W
R
V
L
S
L
P
P
L
A
-
Q
W
R
E
V
M
A
A
L
E
V
G
P
E
A
A
L
A
Y
W
H
R
G
-
F
R
R
-
K
E
D
L
D
----------
P
P
L
A
L
L
P
-------------
L
K
G
L
R
E
A
A
A
L
L
E
E
A
L
R
Q
G
---
K
R
--
I
R
V
H
---------------------------
G
D
Y
--
D
-
A
D
G
-----
L
T
G
T
-
A
I
L
V
R
G
L
A
A
L
G
A
-----------
D
V
H
P
F
I
--
P
S
---
D
-------------------------------------------------------
L
F
L
T
V
-------
D
C
G
---------------
V
E
-----
V
I
V
T
---
D
H
H
----------
T
L
V
V
H
P
A
------
L
--
T
-
P
D
L
K
E
K
P
T
G
A
G
V
A
F
L
L
L
-
W
A
L
H
E
R
L
---------
G
--
L
P
P
P
L
E
Y
A
D
L
A
A
V
G
T
I
-
A
D
V
A
P
L
W
G
W
N
-
R
A
L
V
K
E
G
L
A
R
I
P
-------
A
S
S
W
V
G
L
R
---
L
L
A
E
A
V
G
Y
----
T
G
K
A
V
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
-------------------
L
T
D
D
A
A
E
A
-
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
----------
Q
-
T
L
E
E
A
M
L
R
K
L
L
P
Q
-
A
D
P
E
A
K
A
----
I
---
V
L
L
D
P
-----
E
G
H
P
G
-----
V
M
G
I
V
A
S
R
I
L
E
--
A
T
L
R
P
V
--------
F
L
V
A
----
Q
G
K
G
-
T
V
R
S
L
A
P
---
I
S
A
V
E
A
L
--
R
S
A
E
D
L
L
L
-
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
-
A
L
F
P
A
F
K
---
A
R
V
E
A
Y
A
A
R
F
P
D
P
-
V
R
E
V
A
L
L
D
L
L
P
E
P
G
L
L
P
Q
V
F
R
E
L
A
L
L
E
P
Y
G
E
G
N
P
E
P
L
F
L
L
F
G
A
P
E
E
A
R
R
L
G
E
G
R
-
H
L
A
F
R
L
K
-------
G
----
V
R
V
L
A
W
K
Q
-
G
D
L
A
L
P
P
E
-------
V
E
V
A
G
L
L
S
E
N
A
W
N
G
------
H
L
A
Y
E
V
Q
A
V
D
L
R
K
P
E
A
L
E
G
G
I
APF
A
Y
P
L
P
L
L
E
A
L
A
R
A
R
L
GEG
V
Y
V
P
EDN
P
E
G
L
D
Y
A
W
K
A
GFRLLPPEEAGLWLGLPP
R
P
V
L
GRR
V
E
V
A
L
G
REARARLSAPPVLHTPE
A
R
L
K
A
L
V
H
R
R
L
L
F
A
Y
E
R
RH
P
G
L
F
S
E
A
L
L
A
Y
W
E
V
N
R-------------------
31
HHSearch
95.61
30%
-109
* C4 *
2ZXR
1
RECJ_THET8
A:
[3-530]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
---
R
W
R
V
L
S
-
L
P
P
L
A
Q
W
R
E
V
M
A
A
L
E
V
G
P
E
A
A
L
A
Y
W
H
R
G
-
F
R
R
K
E
D
----
L
D
P
--
P
L
-----
A
L
L
P
-------------
L
K
G
L
R
E
A
A
A
L
L
E
E
A
L
R
Q
G
---
K
R
--
I
R
V
H
---------------------------
G
D
Y
--
D
-
A
D
G
-----
L
T
G
T
-
A
I
L
V
R
G
L
A
A
L
G
A
-----------
D
V
H
P
F
I
--
P
----------------------------------------------------------
S
D
L
F
L
T
V
-------
D
C
---------------
G
V
E
-----
V
I
V
T
---
D
H
H
T
----------
L
V
V
H
P
A
------
L
T
P
D
--
L
-
K
E
K
P
T
G
A
G
V
A
F
L
L
L
-
W
A
L
H
E
R
L
G
L
-----------
P
P
P
L
E
Y
A
D
L
A
A
V
G
T
I
-
A
D
V
A
P
L
W
G
W
N
-
R
A
L
V
K
E
G
L
A
R
I
P
-------
A
S
S
W
V
G
L
R
---
L
L
A
E
A
V
G
Y
----
T
G
K
A
V
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
-------------------
L
T
D
D
A
A
E
A
-
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
----------
Q
-
T
L
E
E
A
M
L
R
K
L
L
P
Q
-
A
D
----
P
E
A
K
A
I
---
V
L
L
D
P
-----
E
G
H
P
G
-----
V
M
G
I
V
A
S
R
I
L
E
--
A
T
L
R
P
V
--------
F
L
V
A
Q
----
G
K
G
-
T
V
R
S
L
A
P
---
I
S
A
V
E
A
L
R
S
--
A
E
D
L
L
L
-
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
-
A
L
F
P
A
F
K
---
A
R
V
E
A
Y
A
A
R
F
P
D
P
V
R
E
V
A
L
L
D
L
-
L
P
E
P
G
L
L
P
Q
V
F
R
E
L
A
L
L
E
P
Y
G
E
G
N
P
E
P
L
F
L
L
F
G
A
P
E
-
E
A
R
R
L
G
E
G
R
H
L
A
F
R
L
K
-----------
G
V
R
V
L
A
W
K
Q
-
G
D
L
-
A
-
L
-----
P
P
E
V
E
V
A
G
L
L
S
E
N
A
W
N
G
------
H
L
A
Y
E
V
Q
A
V
D
L
R
K
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
86.62
31%
-103
- C4 -
1IR6
1
RECJ_THET8
A:
[10-394]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
A
L
L
P
-------------
L
K
G
L
R
E
A
A
A
L
L
E
E
A
L
R
Q
G
---
K
R
--
I
R
V
H
---------------------------
G
D
Y
--
D
-
A
D
G
-----
L
T
G
T
-
A
I
L
V
R
G
L
A
A
L
G
A
-----------
D
V
H
P
F
I
--
P
H
---
R
L
-------
E
-------
E
--
G
-----
Y
G
V
L
M
E
-
R
V
---
P
E
H
--
L
-------
E
-
A
S
D
L
F
L
T
V
-------
D
C
G
I
T
N
H
-
A
E
L
R
E
L
L
E
N
G
V
E
-----
V
I
V
T
---
D
H
H
T
P
G
K
T
P
P
P
-
G
-
L
V
V
H
P
A
------
L
T
P
D
-
L
K
E
K
--
P
T
G
A
G
V
A
F
L
L
L
-
W
A
L
H
E
R
L
---------
G
--
L
P
P
P
L
E
Y
A
D
L
A
A
V
G
T
I
-
A
D
V
A
P
L
W
G
W
N
-
R
A
L
V
K
E
G
L
A
R
I
P
-------
A
S
S
W
V
G
L
R
---
L
L
A
E
A
V
G
Y
----
T
G
K
A
V
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
-------------------
L
T
D
D
A
A
E
A
-
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
----------
Q
-
T
L
E
E
A
M
L
R
K
L
L
P
Q
-
A
D
P
E
A
K
A
----
I
---
V
L
L
D
P
-----
E
G
H
P
G
-----
V
M
G
I
V
A
S
R
I
L
E
--
A
T
L
R
P
V
--------
F
L
V
A
----
Q
G
K
G
-
T
V
R
S
L
A
P
---
I
S
A
V
E
A
L
R
--
S
A
E
D
L
L
L
-
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
-
A
L
F
P
A
F
K
---
A
R
V
E
A
Y
A
A
R
F
P
D
--
P
V
R
E
V
A
L
L
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.20
30%
-106
- C4 -
2ZXR
1
RECJ_THET8
A:
[73-517]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
--
I
R
V
H
---------------------------
G
D
Y
--
D
-
A
D
G
-----
L
T
G
T
-
A
I
L
V
R
G
L
A
A
L
G
A
-----------
D
V
H
P
F
I
--
P
----------------------------------------------------------
S
D
L
F
L
T
V
-------
D
C
---------------
G
V
E
-----
V
I
V
T
---
D
H
H
T
---------
L
-
V
V
H
P
A
------
L
T
P
D
-
L
K
--
E
K
P
T
G
A
G
V
A
F
L
L
L
-
W
A
L
H
E
R
L
---------
G
--
L
P
P
P
L
E
Y
A
D
L
A
A
V
G
T
I
-
A
D
V
A
P
L
W
G
W
N
-
R
A
L
V
K
E
G
L
A
R
I
P
-------
A
S
S
W
V
G
L
R
---
L
L
A
E
A
V
G
Y
T
--
G
K
--
A
V
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
-------------------
L
T
D
D
A
A
E
A
-
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
----------
Q
-
T
L
E
E
A
M
L
R
K
L
L
P
Q
-
A
D
P
E
A
K
A
----
I
---
V
L
L
D
P
-----
E
G
H
P
G
-----
V
M
G
I
V
A
S
R
I
L
E
--
A
T
L
R
P
V
--------
F
L
V
A
----
Q
G
K
G
-
T
V
R
S
L
A
P
---
I
S
A
V
E
A
L
R
S
A
E
--
D
L
L
L
-
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
-
A
L
F
P
A
F
K
A
R
V
E
A
Y
A
A
R
F
P
D
P
V
R
--
E
V
A
L
-
L
D
-
L
L
P
E
P
G
L
L
P
Q
V
F
R
E
L
A
L
L
E
P
Y
G
E
G
N
P
E
P
L
F
L
L
F
G
A
P
E
E
A
R
R
L
G
E
G
R
-
H
L
A
F
R
L
K
-------
G
----
V
R
V
L
A
W
K
Q
-
G
D
L
A
L
P
P
E
V
-------
E
V
A
G
L
L
S
E
N
A
W
N
G
------
H
L
A
Y
E
V
Q
A
V
D
L
R
K
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.89
30%
-99
- C4 -
2ZXO
-
RECJ_THET8
A:
[73-517]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
--
I
R
V
H
---------------------------
G
D
Y
--
D
-
A
D
G
-----
L
T
G
T
-
A
I
L
V
R
G
L
A
A
L
G
A
-----------
D
V
H
P
F
I
--
P
----------------------------------
M
E
-
R
V
---
P
E
---
H
-------
L
E
A
S
D
L
F
L
T
V
-------
D
C
G
I
T
N
H
-
A
E
L
R
E
L
L
E
N
G
V
E
-----
V
I
V
T
---
D
H
H
T
P
G
K
T
P
P
P
-
G
L
-
V
V
H
P
A
------
L
T
P
D
-
L
K
--
E
K
P
T
G
A
G
V
A
F
L
L
L
-
W
A
L
H
E
R
L
---------
G
--
L
P
P
P
L
E
Y
A
D
L
A
A
V
G
T
I
-
A
D
V
A
P
L
W
G
W
N
-
R
A
L
V
K
E
G
L
A
R
I
P
-------
A
S
S
W
V
G
L
R
---
L
L
A
E
A
V
G
Y
T
--
G
K
--
A
V
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
-------------------
L
T
D
D
A
A
E
A
-
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
----------
Q
-
T
L
E
E
A
M
L
R
K
L
L
P
Q
-
A
D
P
E
A
K
A
----
I
---
V
L
L
D
P
-----
E
G
H
P
G
-----
V
M
G
I
V
A
S
R
I
L
E
--
A
T
L
R
P
V
--------
F
L
V
A
----
Q
G
K
G
-
T
V
R
S
L
A
P
---
I
S
A
V
E
A
L
R
S
A
E
--
D
L
L
L
-
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
-
A
L
F
P
A
F
K
A
R
V
E
A
Y
A
A
R
F
P
D
P
V
R
--
E
V
A
L
-
L
D
-
L
L
P
E
P
G
L
L
P
Q
V
F
R
E
L
A
L
L
E
P
Y
G
E
G
N
P
E
P
L
F
L
L
F
G
A
P
E
E
A
R
R
L
G
E
G
R
-
H
L
A
F
R
L
K
-------
G
----
V
R
V
L
A
W
K
Q
-
G
D
L
A
L
P
P
E
V
-------
E
V
A
G
L
L
S
E
N
A
W
N
G
------
H
L
A
Y
E
V
Q
A
V
D
L
R
K
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.80
30%
-99
- C4 -
2ZXP
2
RECJ_THET8
A:
[73-517]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
--
I
R
V
H
---------------------------
G
D
Y
--
D
-
A
D
G
-----
L
T
G
T
-
A
I
L
V
R
G
L
A
A
L
G
A
-----------
D
V
H
P
F
I
--
P
----------------------------------
M
E
-
R
V
---
P
E
---
H
-------
L
E
A
S
D
L
F
L
T
V
-------
D
C
G
I
T
N
H
-
A
E
L
R
E
L
L
E
N
G
V
E
-----
V
I
V
T
---
D
H
H
T
P
G
K
T
P
P
P
-
G
L
-
V
V
H
P
A
------
L
T
P
D
-
L
K
--
E
K
P
T
G
A
G
V
A
F
L
L
L
-
W
A
L
H
E
R
L
---------
G
--
L
P
P
P
L
E
Y
A
D
L
A
A
V
G
T
I
-
A
D
V
A
P
L
W
G
W
N
-
R
A
L
V
K
E
G
L
A
R
I
P
-------
A
S
S
W
V
G
L
R
---
L
L
A
E
A
V
G
Y
T
--
G
K
--
A
V
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
-------------------
L
T
D
D
A
A
E
A
-
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
----------
Q
-
T
L
E
E
A
M
L
R
K
L
L
P
Q
-
A
D
P
E
A
K
A
----
I
---
V
L
L
D
P
-----
E
G
H
P
G
-----
V
M
G
I
V
A
S
R
I
L
E
--
A
T
L
R
P
V
--------
F
L
V
A
----
Q
G
K
G
-
T
V
R
S
L
A
P
---
I
S
A
V
E
A
L
R
S
A
E
--
D
L
L
L
-
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
-
A
L
F
P
A
F
K
A
R
V
E
A
Y
A
A
R
F
P
D
P
V
R
--
E
V
A
L
-
L
D
-
L
L
P
E
P
G
L
L
P
Q
V
F
R
E
L
A
L
L
E
P
Y
G
E
G
N
P
E
P
L
F
L
L
F
G
A
P
E
E
A
R
R
L
G
E
G
R
-
H
L
A
F
R
L
K
-------
G
----
V
R
V
L
A
W
K
Q
-
G
D
L
A
L
P
P
E
V
-------
E
V
A
G
L
L
S
E
N
A
W
N
G
------
H
L
A
Y
E
V
Q
A
V
D
L
R
K
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.68
32%
-90
- C4 -
1IR6
1
RECJ_THET8
A:
[34-394]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
--
I
R
V
H
---------------------------
G
D
Y
--
D
-
A
D
G
-----
L
T
G
T
-
A
I
L
V
R
G
L
A
A
L
G
A
-----------
D
V
H
P
F
I
--
P
H
---
R
L
-------
E
-------
E
--
G
-----
Y
G
V
L
M
E
-
R
V
---
P
E
---
H
-------
L
E
A
S
D
L
F
L
T
V
-------
D
C
G
I
T
N
H
-
A
E
L
R
E
L
L
E
N
G
V
E
-----
V
I
V
T
---
D
H
H
T
P
G
K
T
P
P
P
-
G
L
-
V
V
H
P
A
------
L
T
P
D
-
L
K
--
E
K
P
T
G
A
G
V
A
F
L
L
L
-
W
A
L
H
E
R
L
---------
G
--
L
P
P
P
L
E
Y
A
D
L
A
A
V
G
T
I
-
A
D
V
A
P
L
W
G
W
N
-
R
A
L
V
K
E
G
L
A
R
I
P
-------
A
S
S
W
V
G
L
R
---
L
L
A
E
A
V
G
Y
T
--
G
K
--
A
V
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
-------------------
L
T
D
D
A
A
E
A
-
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
----------
Q
-
T
L
E
E
A
M
L
R
K
L
L
P
Q
-
A
D
P
E
A
K
A
----
I
---
V
L
L
D
P
-----
E
G
H
P
G
-----
V
M
G
I
V
A
S
R
I
L
E
--
A
T
L
R
P
V
--------
F
L
V
A
Q
----
G
K
G
-
T
V
R
S
L
A
P
---
I
S
A
V
E
A
L
R
S
A
E
--
D
L
L
L
-
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
-
A
L
F
P
A
F
K
A
R
V
E
A
Y
A
A
R
F
P
D
P
V
R
--
E
V
A
L
-
L
D
-
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
56.91
18%
-89
- C4 -
3DEV
3
?
A:
[1-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
E
I
F
N
E
I
M
Q
R
V
K
E
A
---
E
T
--
I
I
I
H
---------------------------
R
H
V
RP
D
-
P
D
A
-----
Y
G
S
Q
-
L
G
L
K
L
Y
L
E
R
K
F
P
-----------
E
K
N
I
Y
A
--
T
G
---
E
A
-------
E
-------
P
--
S
-----
L
S
F
I
G
D
--
L
---
D
E
I
--
D
DS-----
V
Y
S
D
A
L
V
I
V
C
-------
D
T
A
N
A
P
R
-
I
D
D
Q
R
Y
-
L
N
G
Q
S
-----
L
I
K
I
---
D
H
H
P
A
T
D
Q
Y
G
D
--
V
N
F
V
N
T
E
------
A
----------
S
S
T
S
E
I
I
F
D
F
I
-
S
H
F
N
D
L
S
-------------
I
I
D
E
H
V
A
R
V
L
Y
L
G
I
V
-
G
D
T
G
R
F
L
F
S
N
-
T
----------
S
-------
P
H
T
M
E
V
A
S
---
Q
L
L
A
-
Y
P
F
------
N
--------------------
H
N
A
E
L
N
K
M
-------------------
S
E
K
D
P
-
K
L
-
M
P
F
Q
-------------------------
G
Y
V
L
Q
----
N
-
F
E
L
--
S
D
S
H
E
-
Y
C
Q
I
K
I
T
N
D
V
L
K
Q
F
D
I
Q
P
N
-----
E
A
S
Q
F
V
N
T
V
A
D
--
I
S
G
L
K
I
W
-------
M
F
G
V
D
E
G
D
Q
I
R
C
-
R
I
R
S
K
G
----
I
T
I
N
D
V
A
N
Q
------
F
G
--
G
G
G
H
P
N
A
S
G
V
S
V
Y
S
W
D
E
F
E
E
L
A
---
Q
A
L
R
Q
K
L
L
E
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
47.83
17%
-95
- C4 -
2QB7
5
PPX1_YEAST
A:
[25-207]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
D
---
V
L
--
T
I
C
V
---------------------------
G
N
E
SA
D
-
M
D
S
-----
I
A
S
A
-
I
T
Y
S
Y
C
Q
Y
I
Y
N
E
G
TYSEE
K
K
K
G
S
F
I
V
P
I
I
DI
P
R
EDL
S
L
R
R
D
V
M
Y
V
L
-------
E
--
K
-----
L
K
I
K
E
E
-
E
L
FF
I
E
D
L
--
K
S
L
K
Q
NVS
Q
G
T
E
L
N
S
Y
L
V
-------
D
N
N
D
T
P
K
-
N
L
K
N
-
Y
--
I
D
N
V
-----
V
G
I
I
---
D
H
H
F
D
L
Q
K
H
L
D
A
E
P
R
I
V
K
V
-------
S
G
----------
S
C
S
S
L
V
F
N
Y
W
-
Y
E
K
L
Q
G
-
D
-----------
R
E
V
V
M
N
I
A
P
L
L
M
G
A
I
L
-
I
D
T
S
N
M
R
R
K
V
-
E
E
S
D
K
L
A
I
E
R
C
Q
-------
A
V
L
S
G
A
V
N
---
E
V
S
A
Q
G
L
E
D
--
S
S
E
F
Y
K
E
I
K
S
R
K
N
D
I
K
G
F
S
V
S
D
I
L
K
K
D
Y
K
Q
F
N
-------------------
F
Q
G
K
G
H
K
G
-
L
E
I
G
L
S
S
I
V
K
R
M
S
W
----------
L
-
F
N
E
H
G
G
E
A
D
F
V
N
Q
-
C
R
R
F
Q
A
E
R
G
L
-
D
---
V
L
V
L
L
-----
T
S
W
R
K
-----
A
G
D
S
H
R
E
L
V
I
L
--
G
D
S
N
V
V
--------
R
E
L
I
E
R
V
S
D
K
L
Q
-
L
Q
L
F
G
G
N
---
L
D
G
G
V
A
M
F
K
Q
L
N
V
E
A
T
R
-
K
Q
V
V
P
Y
L
E
E
A
Y
S
N
L
E
-
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
47.80
24%
-81
- C4 -
2HTM
-
THIG_THET8
A:
[106-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
D
P
L
E
-------------
T
L
---
K
A
A
E
R
L
I
E
--------
E
D
--
F
L
V
L
---------------------------
P
Y
M
--
G
-
P
D
-----------
L
V
L
A
K
R
L
A
A
L
G
T
-----------
A
T
V
M
P
L
--
A
A
---
P
I
-------
G
-------
S
--
G
-----
W
G
V
R
T
R
-
A
L
---
L
E
L
F
A
R
-------
E
K
A
S
L
P
P
V
V
V
-------
D
A
G
L
G
L
P
-
S
H
A
A
E
V
M
E
L
G
L
D
-----
A
V
L
V
---
N
T
A
I
A
E
A
Q
D
P
P
-
A
M
A
E
A
F
R
L
------
A
V
E
A
-
G
R
K
A
Y
L
A
G
P
M
R
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
46.38
17%
-39
- C2 -
4OGE
6
CAS9_ACTNH
A:
[10-1101]
H
H
L
R
V
G
I
D
V
G
TH
S
V
G
L
A
T
L
R
V
D
DHGTPIELL
S
A
L
S
H
I
H
DLS
G
I
A
R
R
A
R
R
L
L
H
H
R
R
T
Q
L
Q
Q
L
D
E
V
L
R
D
L
GFPIPS
M
A
V
R
H
I
A
R
H
R
GWRNPYSKVESLLSPAEESPFMKRKICARQGVSPD
V
C
K
Q
L
L
RAVFKADSPRGSAVSRVAPDPLPGQGSFRRAPKCD
P
E
F
Q
R
F
R
I
I
S
I
V
A
N
L
R
I
S
ETKG
E
N
R
P
LT
A
D
E
R
R
H
V
V
T
F
L
T
EDSQADLT
W
V
D
V
A
E
K
L
GVHRRDLRGTAVHTRSAARPPID
A
T
D
R
I
M
R
Q
TKI
S
S
L
K
T
W
W
E
E
AD
S
E
Q
R
G
A
M
I
R
Y
L
Y
EDPTD
S
E
C
A
E
I
I
AELPEEDQAKLDSLH
L
P
A
G
R
A
AYS
R
E
S
L
T
A
L
S
D
H
M
L
A
T
TDD
L
H
E
A
R
K
R
L
F
G
V
D
D
S
W
A
---------
P
P
A
E
A
I
N
A
P
V
G
N
-
P
S
V
D
-
R
T
L
K
I
V
G
R
Y
-
L
S
A
V
E
S
M
W
G
T
P
E
V
-
I
H
V
-
E
H
V
R
D
G
F
-----------
T
S
E
R
-------------
M
A
D
E
R
D
K
A
N
R
R
R
Y
N
D
N
Q
E
---
A
M
--
K
K
I
Q
---------------------------
R
D
Y
--
G
-
K
E
G
-----
Y
I
S
R
-
G
D
I
V
R
-
L
D
A
L
E
L
-----------
Q
G
--------------------------------------------------------------------
C
A
C
L
-------
Y
C
G
T
T
I
------
G
Y
H
T
C
Q
L
D
-----
H
I
V
P
---
Q
A
G
P
G
S
N
N
R
R
G
-
N
L
V
A
V
-
C
E
------
R
C
N
R
-
S
K
S
N
T
P
F
A
V
W
A
Q
K
C
G
I
P
H
V
G
V
K
E
A
I
G
R
V
R
G
W
R
K
Q
T
--
S
S
E
D
L
T
R
L
K
K
E
V
I
A
R
L
-
R
R
T
Q
E
D
P
E
I
D
E
R
S
M
E
S
V
A
W
M
A
N
E
-------
L
H
H
R
I
A
A
A
---
Y
P
E
T
T
V
M
V
Y
R
G
S
I
T
A
A
A
R
K
A
A
G
I
D
S
R
I
N
L
I
G
E
K
G
------
R
K
D
-------------------
R
I
D
R
R
H
H
A
V
D
A
S
V
V
A
L
M
E
A
S
V
A
K
----------
T
-
L
A
E
R
S
S
L
R
G
E
-----
Q
R
L
T
G
K
E
Q
T
-
W
---
K
Q
Y
T
G
-----
S
---------
T
V
G
A
R
E
H
F
E
M
W
--
R
G
H
M
L
H
--------
L
T
E
L
F
N
E
R
L
A
E
---------------
D
K
V
Y
V
T
Q
N
I
R
L
R
L
S
-
D
G
N
A
H
T
------
V
N
P
-
S
K
L
---------
V
S
H
R
L
G
D
G
L
T
--
V
Q
Q
I
D
-------
R
A
C
T
P
A
L
W
C
A
L
T
R
E
K
D
F
D
E
K
N
G
L
P
A
R
E
D
R
A
I
R
V
H
G
H
E
I
K
S
S
D
-
Y
I
Q
V
F
S
K
RKKTDSD
R
D
E
T
P
F
G
A
I
A
V
R
G
-
G
F
V
E
I
G
P
S
I
H
-
H
A
R
I
Y
R
V
E
G
K
K
P
-----
V
------
Y
A
M
L
R
V
F
T
H
D
L
L
S
Q
R
HGDLFSAVIPPQS
I
S
M
R
C
AE
P
K
L
R
K
A
I
T
T
GNATYL
G
W
V
V
VG
D
E
L
E
I
NVDSFTKY
A
I
G
R
F
L
E
D
F
PNTT
R
W
R
I
CGYDTNS
K
L
T
L
K
P
IVLAAEGLENPS
S
A
V
N
E
I
V
ELK
G
W
R
V
A
I
N
V
L
T
K
V
HPTV
V
R
R
D
ALGRPRYSSRSN
L
P
T
S
W
T
IE
14
PsiBlast_PDB
46.17
24%
-74
- C4 -
3E70
3
?
C:
[119-218]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
E
E
I
R
K
A
---
E
K
PY
V
I
M
F
---------------------------
V
G
F
--
N
-
G
S
G
-----
K
T
T
T
I
A
K
L
A
N
W
L
K
N
H
G
F
-----------
S
V
V
I
A
A
--
S
D
---
T
---------------------------
F
R
A
G
-
A
I
---
E
Q
L
--
E
-------
E
H
A
K
R
I
G
V
K
V
IKHSYGA
D
P
A
A
V
A
Y
-
D
A
I
Q
H
A
K
A
R
G
I
D
-----
V
V
L
I
---
D
T
A
G
R
S
E
T
N
R
N
-
L
M
D
E
M
K
K
I
------
A
R
V
T
-
K
P
N
L
V
I
F
V
G
D
A
L
A
G
N
A
I
-
V
E
Q
A
R
Q
F
N
E
A
V
K
I
D
G
I
I
--
L
T
K
L
D
A
D
A
R
G
G
A
A
L
S
I
-
S
Y
V
I
D
A
P
I
L
F
-
V
G
V
G
Q
G
Y
D
D
L
R
P
-------
F
E
K
E
W
F
L
E
---
R
I
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
45.94
15%
-59
- C4 -
1WPN
5
PPAC_BACSU
A:
[2-155]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
--
I
L
I
F
---------------------------
G
H
Q
NP
D
-
T
D
T
-----
I
C
S
A
-
I
A
Y
A
D
L
K
N
K
L
G
F
-----------
N
A
E
P
V
R
--
L
G
---
Q
V
N
G
E
T
Q
Y
A
L
-------
D
--
Y
-----
F
K
Q
E
S
P
R
L
V
---
E
T
---
A
-------
A
N
E
V
N
G
V
I
L
V
-------
D
H
N
E
R
Q
Q
-
S
I
K
D
--
I
E
E
V
Q
V
-----
L
E
V
I
---
D
H
H
R
I
A
N
F
E
T
A
E
P
L
Y
Y
R
----------------
A
E
P
V
G
C
T
A
T
I
L
N
K
M
Y
-
K
E
N
N
V
---------------
K
I
E
K
E
I
A
G
L
M
L
S
A
I
I
-
S
D
S
L
L
F
K
S
P
T
-
C
T
D
Q
D
V
A
A
A
K
E
L
-------
A
E
I
A
G
V
D
A
---
E
E
Y
G
L
N
M
L
K
--
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
45.27
11%
-62
- C3 -
1G8K
6
AIOA_ALCFA
A:
[4-825]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ND
R
I
T
L
P
P
AN
A
Q
R
T
N
M
T
CHFCIVG
C
G
Y
H
V
Y
K
W
P
EL
E
E
G
G
RAPEQ
N
A
L
G
L
D
F
R
K
Q
LPPLA
V
T
L
T
P
A
M
---
T
N
V
V
T
E
-
H
D
G
A
-
R
Y
D
I
M
V
V
P
D
K
A
C
V
V
N
S
G
L
S
S
T
R
G
-
G
K
M
-
A
S
Y
M
Y
T
P
T
G
--
D
G
K
E
R
L
S
A
P
R
L
YAAD
E
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
---
Q
G
--
V
F
F
S
C
F
DHGGAGGG
F
E
N
T
W
G
T
G
K
L
M
F
SAIQT
P
M
V
--
R
-
I
H
N
-----
R
P
A
Y
-
N
S
E
C
H
A
T
R
E
M
G
I
-----------
G
E
L
N
N
A
--
Y
E
---
D
A
-------
Q
-------
L
--
A
D
V
I
W
S
I
G
N
N
P
Y
-
E
S
Q--
T
N
Y
--
F
-------
L
N
H
W
L
P
N
L
Q
G
-------
A
T
T
S
K
K
K
-
E
R
F
P
N
E
N
F
P
Q
A
R
-----
I
I
F
V
---
D
P
R
-
E
T
P
S
V
A
I
-
A
R
H
V
A
G
N
D
------
R
V
L
H
-
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
-
Y
V
V
E
Q
G
W
I
D
K
P
F
I
E
A
H
T
--
K
G
--
F
D
D
A
V
K
T
N
R
L
S
L
-
D
E
C
S
N
I
T
G
V
P
-
V
D
M
L
K
R
A
A
E
W
S
Y
-------
K
P
K
A
S
G
Q
A
PR
T
M
H
A
Y
E
K
G
I
I
--
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
H
N
V
G
R
R
G
T
G
C
V
R
M
GG
H
Q
E
G
Y
T
R
P
P
YPGDKKIY
I
D
Q
E
L
I
K
G
-
K
G
R
I
M
T
W
W
G
C
N
N
F
Q
TSNN
A
Q
A
L
R
E
A
-
I
L
Q
R
S
A
I
V
K
Q
A
M
Q
-
K
A
R
G
A
T
T
E
E
M
-
V
---
D
V
I
Y
E
-----
A
T
Q
N
G
G
L
F
V
T
S
I
N
L
Y
P
T
K
L
A
E
AA
H
L
M
L
P
A
A
H
P
GE
M
N
L
T
S
M
N
G
E
R
R
I
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
C
L
I
A
A
R
I
A
N
A
L
R
D
M
Y
-
Q
K
D
G
K
A
E
M
A
A
Q
F
-
E
G
-
F
D
W
K
T
E
E
---
D
A
F
N
D
G
F
R
R
A
G
Q
--
P
G
A
P
A
I
D
S
Q
G
G
S
T
G
H
L
V
T
-
Y
D
R
L
R
K
S
G
N
N
G
V
Q
L
P
V
V
--
S
W
D
E
S
K
G
L
V
G
T
E
M
L
Y
T
-
E
G
K
F
D
T
D
-------
D
G
K
A
H
F
K
P
A
P
W
N
G
-
L
P
A
T
V
Q
Q
Q
K
D
-
K
Y
R
F
W
L
N
N
G
R
N
N
E
V
W
Q
T
A
YHDQYN
S
L
M
Q
E
R
Y
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
DVTGG
D
I
V
E
V
Y
N
DF
G
S
T
F
A
M
V
Y
P
V
AEIKRG
Q
T
F
M
L
F
GYVNGIQGDVTTDWTDRDIIPYYK
G
T
W
G
D
I
R
K
VGSM
S
E
F
K
R
TVSFKSRRFG----------------------------------------------------
45
Fugue
45.03
19%
-48
- C3 -
4INO
-
?
A:
[1-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
V
K
V
K
D
Y
F
G
-------------
E
Q
T
I
K
L
P
V
S
K
I
I
Y
L
G
S
F
A
---
E
V
--
P
A
M
F
---------------------------
H
T
W
--
D
R
V
V
G
-----
I
S
D
Y
-
A
F
K
S
D
I
V
K
A
T
----------------
L
K
D
--
P
E
---
R
I
-------
K
-------
P
M
S
S
-----
D
H
A
A
A
L
-
N
V
---
E
L
L
--
K
-------
K
L
S
P
D
L
V
V
T
F
--------
V
G
N
--
P
-
K
A
V
E
H
A
K
K
F
G
I
S
-----
F
L
S
F
QEK
T
I
A
E
V
M
E
D
I
D
T
-
Q
A
K
A
L
E
V
D
A
S
K
K
L
A
K
M
Q
E
-
T
L
D
F
I
A
E
R
L
K
G
V
K
K
K
K
G
-
V
E
L
---
F
H
K
A
N
K
I
S
G
H
Q
A
L
D
S
D
I
L
E
K
G
G
I
D
N
F
G
L
K
Y
V
K
F
G
R
A
D
I
S
V
-
E
K
I
V
K
E
N
P
E
I
I
F
I
W
WISPL
S
P
E
D
V
L
N
N
---
P
K
F
A
T
I
K
A
I
--
K
N
K
Q
V
Y
K
L
-----
P
T
M
D
I
G
G
------
P
R
A
P
L
I
-------------------
S
L
F
I
A
L
K
A
-
H
P
E
A
F
K
G
V
D
I
N
A
I
V
----------
K
-
D
Y
Y
K
V
V
F
D
L
N
D
A
E
-
V
E
P
F
L
W
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
43.95
24%
-71
- C4 -
3DMD
3
?
B:
[119-218]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
E
E
I
R
K
A
---
E
K
PY
V
I
M
F
---------------------------
V
G
F
--
N
-
G
S
G
-----
K
T
T
T
I
A
K
L
A
N
W
L
K
N
H
G
F
-----------
S
V
V
I
A
A
--
S
D
---
T
---------------------------
F
R
A
G
-
A
I
---
E
Q
L
--
E
-------
E
H
A
K
R
I
G
V
K
V
I
K
H
S
YGA
D
P
A
A
V
A
Y
-
D
A
I
Q
H
A
K
A
R
G
I
D
-----
V
V
L
I
---
D
T
A
G
R
S
E
T
N
R
N
-
L
M
D
E
M
K
K
I
------
A
R
V
T
-
K
P
N
L
V
I
F
V
G
D
A
L
A
G
N
A
I
-
V
E
Q
A
R
Q
F
N
E
A
V
K
I
D
G
I
I
--
L
T
K
L
D
A
D
A
R
G
G
A
A
L
S
I
-
S
Y
V
I
D
A
P
I
L
F
-
V
G
V
G
Q
G
Y
D
D
L
R
P
-------
F
E
K
E
W
F
L
E
---
R
I
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
43.85
13%
-51
* C3 *
4NAR
4
?
A:
[4-423]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
E
G
D
P
L
T
-------------
E
E
K
I
K
E
G
L
S
K
L
V
E
D
L
G
K
V
---
K
K
--
V
L
V
V
---------------------------
H
T
D
--
Y
-
T
R
V
-----
D
F
T
H
-
L
V
A
K
N
L
Y
R
F
L
L
E
-----------
R
G
L
--------------------------------------------------------------
K
E
F
H
T
L
N
A
S
---------
G
T
H
R
T
M
K
I
E
E
F
E
K
K
L
G
I
S
RNERR
V
F
F
H
---
N
H
E
F
F
N
P
E
A
L
A
-
F
V
G
T
L
P
A
G
------
F
V
S
E
M
T
E
G
D
L
E
E
E
-------
I
P
-
I
K
V
N
R
L
L
F
E
D
-------------
F
D
A
I
F
F
I
N
G
T
V
P
-
H
E
S
T
G
F
S
G
G
L
-
K
I
V
I
---------------------------------------
P
G
I
------------
A
S
T
E
V
V
D
T
F
H
W
A
A
V
L
M
------------------
G
I
P
K
L
I
G
T
-
V
D
N
P
A
R
K
I
-
I
N
R
A
S
----------
E
M
I
F
E
K
I
K
A
R
S
F
T
L
N
M
V
Y
E
E
E
E
E
V
I
P
-
R
---
A
L
Y
I
D
-----
E
G
Y
E
G
-----
F
L
R
A
Y
E
K
A
C
E
L
--
S
S
Q
L
H
V
--------
K
Y
I
D
R
P
L
R
R
A
V
Q
-
V
I
G
E
E
Y
D
---
E
V
W
T
A
G
K
G
S
Y
K
L
Q
R
P
G
V
M
A
K
G
G
Q
I
I
I
Y
A
P
H
I
K
R
-
F
H
-
S
N
P
Q
M
--
D
K
W
I
R
E
I
G
Y
H
C
K
--
D
Y
V
K
W
Y
L
K
K
H
P
D
F
N
K
N
V
A
A
H
V
I
N
V
R
----
G
A
G
T
F
D
P
E
---
T
G
K
E
E
F
E
F
D
V
I
L
A
T
-
S
I
-------------
P
E
D
E
C
R
A
V
N
L
G
Y
M
D
P
S
K
I
K
K
E
D
F
M
D
E
D
S
L
W
I
V
P
-------
G
G
------
K
Y
L
Y
D
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
43.00
16%
-63
- C4 -
2HAW
9
PPAC_BACSU
A:
[2-155]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
--
I
L
I
F
---------------------------
G
H
Q
NP
D
-
T
D
T
-----
I
C
S
A
-
I
A
Y
A
D
L
K
N
K
L
G
F
-----------
N
A
E
P
V
R
--
L
G
---
Q
V
-------
N
G
E
T
Q
Y
A
L
D
--
Y
-----
F
K
Q
E
S
P
-
R
L
---
V
E
T
--
A
-------
A
N
E
V
N
G
V
I
L
V
-------
D
H
N
E
R
Q
Q
-
S
I
K
D
--
I
E
E
V
Q
V
-----
L
E
V
I
---
D
H
H
R
I
A
N
F
E
T
A
E
P
L
Y
Y
R
A
E
----------------
P
V
G
C
T
A
T
I
L
N
K
M
Y
-
K
E
N
N
V
---------------
K
I
E
K
E
I
A
G
L
M
L
S
A
I
I
-
S
D
S
L
L
F
K
S
P
T
-
C
T
D
Q
D
V
A
A
A
K
E
L
-------
A
E
I
A
G
V
D
A
---
E
E
Y
G
L
N
M
L
K
--
A
G
A
D
L
S
K
K
T
V
E
E
L
I
S
L
D
A
K
E
F
T
L
G
S
K
K
V
E
I
A
Q
-------------------
V
N
T
V
D
I
E
D
-
V
K
K
R
Q
A
E
L
E
A
V
I
S
K
----------
V
-
V
A
E
K
N
L
D
L
F
L
L
V
I
-
T
D
I
L
E
N
D
S
L
A
-
L
---
A
I
G
N
E
-----
A
A
K
V
E
-----
K
A
F
N
V
T
L
E
N
N
T
--
A
L
L
K
G
V
--------
V
S
R
K
K
Q
V
V
P
V
L
T
-
D
A
M
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
40.79
32%
-13
- C4 -
1SZK
5
GABT_ECOLI
A:
[145-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
L
T
G
K
V
N
P
-
Y
S
A
G
M
G
L
M
P
GH
V
Y
R
A
L
Y
P
C
P
L
H
-------------
G
I
S
E
D
D
A
I
A
S
I
H
R
I
F
K
N
D
AAP
E
D
--
I
A
A
I
---------------------------
V
I
E
--
P
-
V
Q
G
SGGF
Y
A
S
S
P
-
A
F
M
Q
R
L
R
A
L
C
D
E
-----------
H
G
I
M
L
I
--
A
D
---
E
V
-------
Q
-------
S
--
G
-----
A
G
-
R
T
G
-
T
L
---
F
A
M
--
E
-------
Q
M
G
V
A
P
D
L
T
T
-------
F
A
K
S
I
A
G
-
G
F
P
L
A
G
V
T
G
R
A
E
-----
V
M
D
A
---
V
A
P
G
G
L
G
G
T
Y
A
-
G
N
P
I
A
C
V
A
------
A
L
E
V
-
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
-
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
--
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
-
D
G
D
H
N
K
P
D
A
K
-
L
T
A
E
I
V
A
R
A
R
D
K
-------
G
L
I
L
L
S
C
G
---
P
Y
Y
N
V
L
R
I
L
--
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
40.15
31%
-14
- C4 -
1SZU
11
GABT_ECOLI
D:
[145-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
L
T
G
K
V
N
P
-
Y
S
A
G
M
G
L
M
P
GH
V
Y
R
A
L
Y
P
C
P
L
H
-------------
G
I
S
E
D
D
A
I
A
S
I
H
R
I
F
K
N
D
AAP
E
D
--
I
A
A
I
---------------------------
V
I
E
--
P
-
V
Q
G
EGGFY
A
S
S
P
-
A
F
M
Q
R
L
R
A
L
C
D
E
-----------
H
G
I
M
L
I
--
A
D
---
E
A
-------
Q
-------
S
--
G
-----
A
G
-
R
T
G
-
T
L
---
F
A
M
--
E
-------
Q
M
G
V
A
P
D
L
T
T
-------
F
A
K
S
I
A
G
-
G
F
P
L
A
G
V
T
G
R
A
E
-----
V
M
D
A
---
V
A
P
G
G
L
G
G
T
Y
A
-
G
N
P
I
A
C
V
A
------
A
L
E
V
-
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
-
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
--
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
-
D
G
D
H
N
K
P
D
A
K
-
L
T
A
E
I
V
A
R
A
R
D
K
-------
G
L
I
L
L
S
C
G
---
P
Y
Y
N
V
L
R
I
L
--
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------