@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0380: (2015-11-30 )
MYNNLRDFIEALEKKRDLIRIKKEVSTILEMTEIHRRVSLNKGPAIIFENVVTENGKSVIPVLVNLFGTIERIAFGLNISPGELRDLGKLLAFLQSPEPPKNLKDVIKMFPLLKVVLSMRSKIVNKAPCQEVVLTGDDVDLSLLPIQTCWPNEPAPLITWPIVITKGPTEDKQDNFNLGIYRMQVMDKKTTLMRWLAHRGGASHHKRWKENGRSIKFPAAAVIGSDPATLIAAVTPVPETLSEYQFAGLLRKKPLELVNCKTISLQVPAHAEIVLEGYVSLDSYRNEGPYGDHTGYYNSVEQFPEFNITAITMRKNPIYLSTFTGKPPDEPSILGEALNEIFVPILINQFPEIVDFYLPPEGCSYRIAVVSVKKSYPGHAKRIIMGIFSFLKQFLYTKFIIVVDDDINIRDWKEVMWAISTRMDPVRDTVMIENAPIDYLDFASPESGLGGKMGFDATNKMPPETKREWGKKIEMSEEIVKKVTEKWDEYGLTDD
Atome Classification :
(20 SA)
---.....--....10........20.......-.30........40........50-----.-----.-.......60........70.........80---.-....-----..--------.------90........100-.......110-----.........----120.....-..130.---.....---.140.......150...---..-..-.160.......170.......180.......190.......200.......210....---------....220......--.230....-...240.......250.......260..----.....270......-.-280...---------------....290.....--..300.-.--.--.--....310.......320.......----330-.-....-...340.....-..-350--...-....-.360-...-..----..------------.-------370------.-----......--------380.--.---.....390...----------..------..400.--......----410-.......420.......430-.....---.----...440.......--450.......460------...--.------....---470....------...---480.......490...---------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MYN
N
L
--
R
D
F
I
E
A
L
E
K
K
R
D
L
I
R
I
K
K
E
V
S
T
I
-
L
E
M
T
E
I
H
R
R
VSLNKG
P
A
I
I
F
E
N
------
V
-----V-TENGK
S
V
I
P
V
L
V
N
L
F
G
T
I
-
E
R
I
AFGLNIS
P
---
G
-
E
L
R
D
-----
L
G
--------
K
------
L
L
A
F
LQSPEP
P
K
N
-
L
K
D
V
I
K
M
F
-------
P
L
L
K
V
V
L
S
M
----
R
S
K
IVNKA-PC
Q
E
V
V
---
L
TGDD---V
D
L
S
L
L
P
I
QTCW-PNEP---A
P
-
L
I
-
T
W
P
I
V
I
TKGPTEDKQDNFN
L
G
I
Y
R
M
Q
VMDK
K
T
T
L
M
R
W
L
A
HRGG
A
S
H
H
K
R
W
K
E-NG
R
S
I---------KFP
A
A
AVIGSDP
A
--
T
L
I
A
A
VTP-V
P
E
T
L
S
E
Y
Q
F
A
G
L
L
R
KKP
L
E
L
V
N
C
K
T
I
S
----
L
QVPA
H
A
E
I
V
L
E
G
Y
-
V
-
S
L
D
SYR---------------NEGPYGDHTGY
Y
--
N
S
V
-
E
Q-F--P--E--F
N
I
T
A
I
T
MRKN
P
I
Y
L
STFTGKPPD----
E
-
P
-
S
-
I
L
G
E
-
A
L
N
E
I
F
V
P
I
L
I
-NQ-
F
P
---
E
I
V
-
D
FYL-PPE--GC
S
-
Y
R
----
I
A
------------
V
-------
V
S
V
------K-----KSYPG
H
--------
A
K
R
I
--
I
---
M
G
I
F
S
F
L
K
Q
F
L
----------Y
T
------
K
F
I
I
V
V--DDDI
N
I
----
R
D
W
-
K
E
V
M
W
A
I
S
TRMDPVR
D
T
V
---
M
IENA---P----I
D
Y
LDFASPESGL--GGKMGFDATNKM-------P
P
E
--
T
------
K
R
E
W---GKKIE
M
S
------
E
E
I
---
V
K
K
V
T
E
K
W
D
EYGLTDD---------------
20
HHSearch
99.08
58%
-105
* C7 *
2IDB
2
UBID_ECOLI
A:
[6-491]
----
Y
N
D
L
--
R
D
F
L
T
L
L
E
Q
Q
G
E
L
K
R
I
T
L
P
V
D
P
H
-
L
E
I
T
E
I
A
D
R
T
L
R
A
G
G
P
A
L
L
F
E
N
------
P
---------
K
G
Y
S
-
M
P
V
L
C
N
L
F
G
T
P
-
K
R
V
A
M
G
M
G
Q
E
D
---
V
S
A
L
R
E
-----
V
G
--------
K
------
L
L
A
F
L
K
E
P
E
P
P
K
G
-
F
R
D
L
-------------------
M
----
P
T
K
R
L
R
G
A
-
P
C
Q
Q
K
I
---
V
S
G
D
D
---
V
D
L
N
R
I
P
I
M
T
C
W
-
P
E
D
A
---
A
P
-
L
I
-
T
W
G
L
T
V
T
R
G
P
H
K
E
R
Q
---
N
L
G
I
Y
R
Q
Q
L
I
G
K
N
K
L
I
M
R
W
L
S
H
R
G
G
A
L
D
Y
Q
E
W
C
A
A
H
P
-
G
E
---------
R
F
P
V
S
V
A
L
G
A
D
P
A
--
T
I
L
G
A
V
T
P
-
V
P
D
T
L
S
E
Y
A
F
A
G
L
L
R
G
T
K
T
E
V
V
K
C
I
S
N
D
----
L
E
V
P
A
S
A
E
I
V
L
E
G
Y
-
I
-
E
Q
G
E
T
A
---------------
P
E
G
P
Y
G
D
H
T
G
Y
Y
--
N
E
V
-
D
S
-
F
--
P
--
V
--
F
T
V
T
H
I
T
Q
R
E
D
A
I
Y
H
S
T
Y
T
G
R
P
P
D
----
E
-
P
-
A
-
V
L
G
V
-
A
L
N
E
V
F
V
P
I
L
Q
-
K
Q
-
F
P
---
E
I
V
-
D
F
Y
L
-
P
P
E
--
G
C
S
-
Y
R
----
L
A
------------
V
-------
V
T
I
------
K
-----
K
Q
Y
A
G
H
--------
A
K
R
V
--
M
---
M
G
V
W
S
F
L
R
Q
F
M
----------
Y
T
------
K
F
V
I
V
C
--
D
D
D
V
N
A
----
R
D
W
-
N
D
V
I
W
A
I
T
T
R
M
D
P
A
R
D
T
V
---
L
V
E
N
T
---
P
----
I
D
Y
L
D
F
A
S
P
V
S
G
L
--
G
S
K
M
G
L
D
A
T
N
K
W
-------
P
G
E
--
T
------
Q
R
E
W
---
G
R
P
I
K
K
D
------
P
D
V
---
V
A
H
I
D
A
I
W
D
E
L
A
I
F
-----------------
31
Fugue
83.47
28%
-87
- C7 -
4IWS
-
?
A:
[23-515]
M
N
R
S
A
L
D
F
--
R
H
F
V
D
H
L
R
R
Q
G
D
L
V
D
V
H
T
E
V
D
A
N
-
L
E
I
G
A
I
T
R
R
V
Y
E
R
R
A
P
A
P
L
F
H
N
------
I
-----
R
D
S
L
P
G
A
R
V
L
G
A
P
A
G
L
--------------
R
A
---
D
-
R
A
R
A
-----
H
S
--------
R
------
L
A
L
H
F
G
L
P
E
H
-
S
G
-
P
R
D
I
V
A
M
L
-------
R
A
A
M
R
A
E
P
I
----
A
P
R
R
L
E
R
G
-
P
V
Q
E
N
V
---
W
L
G
E
Q
---
V
D
L
T
R
F
P
V
P
L
L
H
-
E
Q
D
G
---
G
R
-
Y
F
G
T
Y
G
F
H
V
V
Q
T
P
D
G
S
-
W
D
S
W
S
V
G
--
R
L
M
L
V
D
R
N
T
L
A
G
P
T
I
P
T
Q
H
I
G
I
I
R
E
Q
W
R
R
-
L
G
K
P
-----------
T
P
W
A
M
A
L
G
A
P
P
A
--
A
L
A
A
A
G
M
P
-
L
P
E
G
V
S
E
A
G
Y
V
G
A
L
V
G
E
P
V
E
V
V
R
T
Q
T
N
G
----
L
W
V
P
A
N
T
E
I
V
L
E
G
E
-
I
-
S
L
D
E
T
A
---------------
L
E
G
P
M
G
E
Y
H
G
Y
S
--
F
P
I
G
K
P
-
Q
--
P
--
L
--
F
H
V
H
A
L
S
F
R
D
Q
P
I
L
P
I
C
V
A
G
T
P
P
E
----
E
-
N
-
H
T
I
W
G
T
-
M
I
S
A
Q
L
L
D
V
A
Q
-
N
A
G
L
P
-----
V
-
D
M
V
W
-------
C
S
-
Y
E
AATC
W
A
------------
V
-------
L
S
I
------
D
-----
V
Q
R
L
A
A
L
GTD
A
A
A
F
A
A
R
V
--
A
---
E
T
V
F
G
S
H
A
G
H
L
----------
V
P
------
K
L
I
L
V
G
--
N
D
-
I
D
V
----
T
E
I
-
D
Q
V
V
W
A
L
A
T
R
A
H
P
L
H
D
H
F
---
A
F
P
Q
I
---
R
DFPM
V
P
Y
L
D
A
E
D
K
A
R
G
S
--
G
G
R
L
V
I
N
C
---
L
-------
Y
P
E
--
Q
F
A
GQMR
A
A
T
A
---
S
F
R
H
A
Y
P
------
T
A
L
---
R
R
R
V
E
E
R
W
S
D
Y
G
F
------------------
1
PsiBlast_PDB
82.65
28%
-83
- C7 -
4ZA9
4
?
A:
[10-499]
-------
F
--
R
S
F
V
E
A
L
K
V
D
N
D
L
V
E
I
N
T
P
I
D
P
N
-
L
E
A
A
A
I
T
R
R
V
C
E
T
N
D
K
A
P
L
F
N
N
------
L
-----
I
G
M
K
N
G
------
L
F
R
I
L
G
------------
A
P
---
G
-
S
L
R
K
SSADR
Y
G
--------
R
------
L
A
R
H
L
A
L
P
-
P
T
A
S
-
M
R
E
I
L
D
K
M
-------
L
S
A
S
D
M
P
P
I
----
P
P
T
I
V
P
T
G
-
P
C
K
E
N
S
---
L
D
D
S
E
---
F
D
L
T
E
L
P
V
P
L
I
H
-
K
S
D
G
---
G
K
-
Y
I
Q
T
Y
G
M
H
I
V
Q
S
P
D
G
T
W
T
---
N
W
S
I
A
R
A
M
V
H
D
K
N
H
L
T
G
L
V
I
P
P
Q
H
I
W
Q
I
H
Q
M
W
K
K
-
E
G
R
S
----------
D
V
P
W
A
L
A
F
G
V
P
P
A
--
A
I
M
A
S
S
M
P
-
I
P
D
G
V
T
E
A
G
Y
V
G
A
M
T
G
S
S
L
E
L
V
K
C
D
T
N
D
----
L
Y
V
P
A
T
S
E
I
V
L
E
G
T
-
L
-
S
I
S
E
T
G
---------------
P
E
G
P
F
G
E
M
H
G
Y
I
FP
G
D
T
-
H
L
-
G
--
A
--
K
--
Y
K
V
N
R
I
T
Y
R
N
N
A
I
M
P
M
S
S
C
G
R
L
T
D
----
E
-
T
H
T
-
M
I
G
S
L
A
A
A
E
I
R
K
L
C
Q
Q
-
N
D
-
L
P
----
I
T
-
D
A
F
A
-
P
F
E
--
S
Q
V
-
T
W
----
V
A
L
R
V
D
T
E
K
-----
L
-------
R
A
M
------
K
-----
T
T
S
E
G
F
--------
R
K
R
V
--
G
---
D
V
V
F
N
H
K
A
G
Y
T
----------
I
H
------
R
-
L
V
L
V
--
G
D
D
I
D
V
----
Y
E
G
-
K
D
V
L
W
A
F
S
T
R
C
R
P
G
M
D
E
T
---
L
F
E
D
V
---
R
GFPL
I
P
Y
M
G
H
G
N
G
P
A
H
R
--
G
G
K
V
V
S
D
A
L
--
M
-------
P
T
E
YT
T
------
G
R
N
W
E--
A
A
D
F
N
Q
S
YP----
E
D
L
---
K
Q
K
V
L
D
N
W
T
K
M
G
F
S
-----------------
2
PsiBlast_PDB
82.39
28%
-83
- C7 -
4ZAA
8
?
A:
[10-499]
-------
F
--
R
S
F
V
E
A
L
K
V
D
N
D
L
V
E
I
N
T
P
I
D
P
N
-
L
E
A
A
A
I
T
R
R
V
C
E
T
N
D
K
A
P
L
F
N
N
------
L
-----
I
G
M
K
N
G
------
L
F
R
I
L
G
------------
A
P
---
G
-
S
L
R
K
SSADR
Y
G
--------
R
------
L
A
R
H
L
A
L
P
-
P
T
A
S
-
M
R
E
I
L
D
K
M
-------
L
S
A
S
D
M
P
P
I
----
P
P
T
I
V
P
T
G
-
P
C
K
E
N
S
---
L
D
D
S
E
---
F
D
L
T
E
L
P
V
P
L
I
H
-
K
S
D
G
---
G
K
-
Y
I
Q
T
Y
G
M
H
I
V
Q
S
P
D
G
T
W
T
---
N
W
S
I
A
R
A
M
V
H
D
K
N
H
L
T
G
L
V
I
P
P
Q
H
I
W
Q
I
H
Q
M
W
K
K
-
E
G
R
S
----------
D
V
P
W
A
L
A
F
G
V
P
P
A
--
A
I
M
A
S
S
M
P
-
I
P
D
G
V
T
E
A
G
Y
V
G
A
M
T
G
S
S
L
E
L
V
K
C
D
T
N
D
----
L
Y
V
P
A
T
S
E
I
V
L
E
G
T
-
L
-
S
I
S
E
T
G
---------------
P
E
G
P
F
G
E
M
H
G
Y
I
FP
G
D
T
-
H
L
-
G
--
A
--
K
--
Y
K
V
N
R
I
T
Y
R
N
N
A
I
M
P
M
S
S
C
G
R
L
T
D
----
E
-
T
H
T
-
M
I
G
S
L
A
A
A
E
I
R
K
L
C
Q
Q
-
N
D
-
L
P
----
I
T
-
D
A
F
A
-
P
F
E
--
S
Q
V
-
T
W
----
V
A
L
R
V
D
T
E
K
-----
L
-------
R
A
M
------
K
-----
T
T
S
E
G
F
--------
R
K
R
V
--
G
---
D
V
V
F
N
H
K
A
G
Y
T
----------
I
H
------
R
-
L
V
L
V
--
G
D
D
I
D
V
----
Y
E
G
-
K
D
V
L
W
A
F
S
T
R
C
R
P
G
M
D
E
T
---
L
F
E
D
V
---
R
GFPL
I
P
Y
M
G
H
G
N
G
P
A
H
R
--
G
G
K
V
V
S
D
A
L
--
M
-------
P
T
E
YT
T
------
G
R
N
W
E--
A
A
D
F
N
Q
S
YP----
E
D
L
---
K
Q
K
V
L
D
N
W
T
K
M
G
F
S
-----------------
3
PsiBlast_PDB
82.37
26%
-82
- C7 -
4ZAD
3
?
A:
[9-511]
-------
F
--
R
D
F
I
Q
V
L
K
N
E
G
D
L
I
E
I
D
T
E
V
D
P
N
-
L
E
V
G
A
I
T
R
K
A
Y
E
N
K
L
A
A
P
L
F
N
N
------
L
-------
K
Q
D
P
E
N
I
D
P
K
--
N
L
F
R
I
L
-
G
--------
C
P
---
G
-
G
L
R
G
-----
F
G
--------
N
DH
A
R
I
A
L
H
L
G
L
D
S
Q
T
P
M
K
E
-
I
I
D
F
L
V
A
N
-------
R
N
P
K
K
Y
I
P
P
----
V
L
V
P
N
D
Q
S
-
P
H
K
K
H
H
---
L
T
K
E
Q
---
I
D
L
T
K
L
P
V
P
L
L
H
-
H
G
D
G
---
G
K
-
F
I
Q
T
Y
G
M
W
V
L
Q
T
P
D
K
S
W
T
---
N
W
S
I
A
R
G
M
V
H
D
S
K
S
I
T
G
L
V
I
N
P
Q
H
V
K
Q
V
S
D
A
W
V
A
-
A
G
K
G
D
---------
K
I
P
F
A
L
C
F
G
V
P
P
A
--
A
I
L
V
S
S
M
P
-
I
P
D
G
A
T
E
A
E
Y
I
G
G
L
C
N
Q
A
V
P
V
V
K
C
E
T
N
D
----
L
E
V
P
A
D
C
E
M
V
F
E
G
Y
-
L
-
D
R
D
T
L
V
---------------
R
E
G
P
F
G
E
M
H
G
Y
C
--
F
P
K
-
D
H
-
H
T
Q
P
--
L
--
Y
R
V
N
H
I
S
Y
R
D
Q
A
I
M
P
I
S
N
P
G
L
C
T
D
----
E
-
T
-
H
-
T
L
I
G
-
G
L
V
S
A
E
T
K
Y
L
I
-
S
Q
-
H
P
V
L
S
K
I
V
E
D
V
F
T
-
P
Y
E
--
A
Q
A
-
L
W
----
L
A
------------
V
K
I
N
T
H
E
L
V
K
L
------
K
-----
T
N
------------
A
K
E
L
S
N
L
---
V
G
D
F
L
F
R
S
K
E
C
----------
Y
K
VCSIL-
H
E
I
I
L
V
--
G
D
D
I
D
I
----
F
D
F
-
K
Q
L
I
W
A
Y
T
T
R
H
T
P
V
Q
D
Q
L
---
Y
F
D
D
V
K--
P
----
F
A
L
A
P
F
A
S
Q
G
P
L
I
--
K
T
R
Q
G
G
K
C
V
T
T
C
IFPKQFT
D
P
D
--
F
------
E
F
V
T
---
C
N
F
N
G
Y
P
------
E
E
V
---
K
N
K
I
S
Q
N
W
D
K
Y
Y
K
------------------
6
PsiBlast_PDB
82.10
26%
-84
- C7 -
4ZAC
4
FDC1_YEAST
A:
[10-501]
-------
F
--
R
D
F
I
Q
V
L
K
D
E
D
D
L
I
E
I
T
E
E
I
D
P
N
-
L
E
V
G
A
I
M
R
K
A
Y
E
S
H
L
P
A
P
L
F
K
N
------
L
-----------
K
G
A
S
K
D
L
F
S
I
L
G
C
-------
P
A
G
L
R
S
---
K
-
E
K
G
D
-----
H
G
--------
R
------
I
A
H
H
L
-
G
L
D
P
K
T
T
-
I
K
E
I
I
D
Y
L
L
E
C
K
E
KE
P
L
P
P
I
T
V
P
---------
V
S
S
A
-
P
C
K
T
H
I
---
L
S
E
E
K
---
I
H
L
Q
S
L
P
T
P
Y
L
H
-
V
S
D
G
---
G
K
Y
L
Q
-
T
Y
G
M
W
I
L
Q
T
P
--
D
K
K
W
T
-
N
W
S
I
A
R
G
M
V
V
D
D
K
H
I
T
G
L
V
I
K
P
Q
H
I
R
Q
I
A
D
S
W
A
A
-
I
G
K
A
N
---------
E
I
P
F
A
L
C
F
G
V
P
P
A
--
A
I
L
V
S
S
M
P
-
I
P
E
G
V
S
E
S
D
Y
V
G
A
I
L
G
E
S
V
P
V
V
K
C
E
T
N
D
----
L
M
V
P
A
T
S
E
M
V
F
E
G
T
-
L
-
S
L
T
D
T
H
---------------
L
E
G
P
F
G
E
M
H
G
Y
V
--
F
K
S
-
Q
G
-
H
--
P
--
C
P
L
Y
T
V
K
A
M
S
Y
R
D
N
A
I
L
P
V
S
N
P
G
L
C
T
D
----
E
-
T
H
T
-
L
I
G
S
-
L
V
A
T
E
A
K
E
L
A
I
-
E
S
-
G
L
---
P
I
L
-
D
A
F
M
-
P
Y
E
--
A
Q
A
L
W
L
----
I
L
------------
K
-------
V
D
L
------
K
G
L
Q
A
L
K
T
T
P
E
E
--------
F
C
K
K
--
V
---
G
D
I
Y
F
R
T
K
V
G
F
----------
I
V
------
H
E
I
I
L
V
--
A
D
D
I
D
I
----
F
N
F
-
K
E
V
I
W
A
Y
V
T
R
H
T
P
V
A
D
Q
M
---
A
F
D
D
V
TSF
P
----
L
A
P
F
V
S
Q
S
S
R
S
K
T
MK
G
G
K
C
V
T
N
C
I
F
R
Q
-------
Q
Y
E
--
R
------
S
F
D
Y
I
T
C
N
F
E
K
G
Y
P
------
K
G
L
---
V
D
K
V
N
E
N
W
K
R
Y
G
Y
K
-----------------
4
PsiBlast_PDB
80.94
25%
-79
- C7 -
4IWS
-
?
A:
[29-515]
------
D
F
--
R
H
F
V
D
H
L
R
R
Q
G
D
L
V
D
V
H
T
E
V
D
A
N
-
L
E
I
G
A
I
T
R
R
V
Y
E
R
R
A
P
A
P
L
F
H
N
------
I
-----------
R
D
S
L
P
-------
G
A
-
R
V
L
G
A
P
A
G
L
R
A
---
D
-
R
A
R
A
-----
H
S
--------
R
------
L
A
L
H
F
G
L
P
E
-
H
S
G
-
P
R
D
I
V
A
M
L
-------
R
A
A
M
R
A
E
P
I
----
A
P
R
R
L
E
R
G
-
P
V
Q
E
N
V
---
W
L
G
E
Q
---
V
D
L
T
R
F
P
V
P
L
L
H
-
E
Q
D
G
---
G
R
-
Y
F
G
T
Y
G
F
H
V
V
Q
T
P
-
D
G
S
W
D
S
W
S
V
G
--
R
L
M
L
V
D
R
N
T
L
A
G
P
T
I
P
T
Q
H
I
G
I
I
R
E
Q
W
R
R
-
L
G
K
P
T
-----------
P
W
A
M
A
L
G
A
P
P
A
--
A
L
A
A
A
G
M
P
-
L
P
E
G
V
S
E
A
G
Y
V
G
A
L
V
G
E
P
V
E
V
V
R
T
Q
T
N
G
----
L
W
V
P
A
N
T
E
I
V
L
E
G
E
-
I
-
S
L
D
E
T
A
---------------
L
E
G
P
M
G
E
Y
H
G
Y
S
--
F
P
I
-
G
K
P
Q
--
P
--
L
--
F
H
V
H
A
L
S
F
R
D
Q
P
I
L
P
I
C
V
A
G
T
P
P
E
----
E
N
H
-
T
-
I
W
G
T
-
M
I
S
A
Q
L
L
D
V
A
Q
-
N
A
G
L
P
-----
V
-
D
M
V
W
-------
C
S
-
Y
E
----
A
A
TC
W
A
V
L
S
I
D
V
Q
R
L
-------
A
A
L
------
G
-----
T
D
A
A
A
F
--------
A
A
R
V
--
A
---
E
T
V
F
G
S
H
A
G
H
L
----------
V
P
------
K
-
L
I
L
V
--
G
N
D
I
D
V
----
T
E
I
-
D
Q
V
V
W
A
L
A
T
R
A
H
P
L
H
D
H
F
AFP
Q
I
R
D
F
---
P
M---
V
P
Y
L
D
A
E
D
K
A
R
G
S
--
G
G
R
L
---
V
I
N
C
L
-------
Y
P
E
--
Q
------
F
A
G
Q
---
M
R
A
A
T
A
S
FRHAYP
T
A
L
---
R
R
R
V
E
E
R
W
S
D
Y
G
F
------------------
5
PsiBlast_PDB
80.43
25%
-81
- C7 -
4IP2
3
?
A:
[29-516]
------
D
F
--
R
H
F
V
D
H
L
R
R
Q
G
D
L
V
D
V
H
T
E
V
D
A
N
-
L
E
I
G
A
I
T
R
R
V
Y
E
R
R
A
P
A
P
L
F
H
N
------
I
-----------
R
D
S
L
P
-------
G
A
-
R
V
L
G
A
P
A
G
L
R
A
---
D
-
R
A
R
A
-----
H
S
--------
R
------
L
A
L
H
F
G
L
P
E
-
H
S
G
-
P
R
D
I
V
A
M
L
-------
R
A
A
M
R
A
E
P
I
----
A
P
R
R
L
E
R
G
-
P
V
Q
E
N
V
---
W
L
G
E
Q
---
V
D
L
T
R
F
P
V
P
L
L
H
-
E
Q
D
G
---
G
R
-
Y
F
G
T
Y
G
F
H
V
V
Q
T
P
-
D
G
S
W
D
S
W
S
V
G
--
R
L
M
L
V
D
R
N
T
L
A
G
P
T
I
P
T
Q
H
I
G
I
I
R
E
Q
W
R
R
-
L
G
K
P
T
-----------
P
W
A
M
A
L
G
A
P
P
A
--
A
L
A
A
A
G
M
P
-
L
P
E
G
V
S
E
A
G
Y
V
G
A
L
V
G
E
P
V
E
V
V
R
T
Q
T
N
G
----
L
W
V
P
A
N
T
E
I
V
L
E
G
E
-
I
-
S
L
D
E
T
A
---------------
L
E
G
P
M
G
E
Y
H
G
Y
S
--
F
P
I
-
G
K
P
Q
--
P
--
L
--
F
H
V
H
A
L
S
F
R
D
Q
P
I
L
P
I
C
V
A
G
T
P
P
E
----
E
N
H
-
T
-
I
W
G
T
-
M
I
S
A
Q
L
L
D
V
A
Q
-
N
A
G
L
P
-----
V
-
D
M
V
W
-------
C
S
-
Y
E
----
A
A
TC
W
A
V
L
S
I
D
V
Q
R
L
-------
A
A
L
------
G
-----
T
D
A
A
A
F
--------
A
A
R
V
--
A
---
E
T
V
F
G
S
H
A
G
H
L
----------
V
P
------
K
-
L
I
L
V
--
G
N
D
I
D
V
----
T
E
I
-
D
Q
V
V
W
A
L
A
T
R
A
H
P
L
H
D
H
F
AFP
Q
I
R
D
F
---
P
M---
V
P
Y
L
D
A
E
D
K
A
R
G
S
--
G
G
R
L
---
V
I
N
C
L
-------
Y
P
E
--
Q
------
F
A
G
Q
---
M
R
A
A
T
A
S
FRHAYP
T
A
L
---
R
R
R
V
E
E
R
W
S
D
Y
G
F
G
-----------------
37
Fugue
47.20
18%
-57
- C3 -
4RAP
1
TIBC_ECOH1
A:
[10-391]
-----
I
T
P
--
P
D
T
P
T
Q
A
G
P
E
N
I
F
Y
D
F
N
D
G
A
R
V
L
-
L
P
E
G
K
W
H
V
R
L
L
D
A
D
S
E
N
I
L
F
C
C
------
D
V
D
K
G
W
V
-
T
S
S
K
K
Y
F
V
R
F
R
I
Q
V
F
R
Q
G
-
A
T
P
L
L
D
E
T
L
-------
K
L
K
D
-----
R
P
--------
V
------
L
I
S
F
-----
P
T
G
T
-
L
G
D
L
L
G
W
F
-------
P
Y
A
E
R
F
Q
S
L
----
H
K
C
R
L
E
C
T
M
S
Q
D
I
I
D
---
L
L
A
P
Q
---
Y
P
----
Q
I
Q
F
S
T
-
P
D
K
P
RTV
A
P
-
Y
A
-
T
Y
R
V
G
L
Y
F
G
G
D
T
N
N
Q
---------------
P
V
D
F
R
K
V
G
F
H
R
----------------------------
S
A
G
Y
I
L
G
V
D
P
R
--
E
A
P
V
R
L
D
L
-
S
A
P
R
V
I
A
A
P
Y
V
C
I
A
T
Q
S
T
C
Q
A
K
Y
W
N
N
G
T
----
G
W
S
E
V
I
A
H
L
K
S
L
G
Y
R
V
M
C
I
D
R
----------------------
D
A
H
Y
G
-----------------------
Q
G
F
V
W
N
H
I
P
W
G
A
E
D
F
T
G
K
L
P
------------
L
Q
E
-
R
V
N
L
L
R
H
---------------
A
-
S
F
F
I
G
L
P
S
--
G
L
S
-
W
L
----
A
W
------------
A
-------
T
R
I
------
P
---------------------
V
V
--
L
---
I
S
G
F
S
L
P
N
S
E
F
----------
Y
T
------
P
W
-
R
V
F
--
N
S
H
G
C
Y
----
G
C
W
-
D
D
---------------------
T
S
L
---
N
----
F
D
H
H
D
F
L
W
C
P
R
H
K
--
N
T
D
R
Q
F
E
C
T
R
L
I
-------
T
G
A
--
Q
------
V
N
G
V
---
I
N
K
L
H
R
S
------
L
T
-----------------------------------
36
Fugue
42.18
20%
-62
- C2 -
4RDQ
9
?
A:
[1-366]
------------------------------
T
V
T
-
Y
T
N
R
V
A
D
A
R
L
G
T
F
S
Q
L
L
L
Q
W
K
G
------
S
-----
I
-
Y
K
L
L
Y
S
E
F
L
I
F
I
S
L
Y
F
A
I
--
S
L
V
Y
R
L
I
L
S
E
---
S
-
Q
R
L
M
-----
F
E
--------
K
------
L
A
L
Y
C
N
S
Y
----------
A
E
L
I
-------
P
V
S
F
V
L
G
F
Y
----
V
S
L
V
V
S
R
W
-
W
A
Q
Y
E
S
---
I
P
-----------------
W
-
P
D
R
I
---
M
N
-
L
V
-
S
C
N
V
--------
D
G
E
D
E
Y
G
R
-
L
L
R
R
T
L
M
R
Y
S
N
L
C
S
V
L
I
L
R
S
V
S
T
A
V
Y
K
R
F
P
------------------
S
M
E
H
V
V
R
A
G
L
M
--
T
-----------
P
E
E
H
K
K
F
E
S
L
N
S
P
H
N
K
F
W
I
P
C
V
W
F
S
----
N
L
A
V
K
A
R
N
---
E
G
R
-
I
-
R
-
D
S
V
L
---------------
L
Q
G
I
L
N
E
L
N
T
L
R
--
S
Q
C
-
G
R
-
L
--
Y
--
G
--
Y
D
W
I
S
I
---------------
P
L
V
----
Y
-
T
-
Q
-
V
V
T
V
-
A
V
Y
S
F
F
L
A
C
L
I
G
R
Q
-
F
-----------
L
-
D
P
E
-------------------------------------------------
K
A
Y
P
G
H
--------
E
L
D
L
--
F
---
V
P
V
F
T
F
L
Q
F
F
F
----------
Y
A
------
G
W
L
K
V
A
--
E
Q
L
I
N
P
FGED
D
D
D
-
F
E
T
N
W
L
I
D
R
N
L
Q
V
S
L
M
A
V
D
E
-
M
H
Q
D
L
---
P
----
I
-----------
L
--
E
K
D
L
Y
W
N
E
P
D
P
Q
-------
P
P
Y
--
T
------
A
A
T
A
---
E
Y
K
----------------------
R
P
S
F
L
G
S
T
F
D
IS-------------
34
Fugue
42.13
16%
-31
- C5 -
4Q86
4
YCAO_ECOLI
A:
[2-583]
---
T
Q
T
F
I
--
P
G
K
D
A
A
L
E
D
--
S
I
A
R
F
Q
Q
K
L
S
D
L
G
F
Q
I
E
E
A
S
W
L
N
P
V
P
N
V
W
S
V
H
I
R
D
KECAL
C
F
-----
T
-
N
G
K
G
A
T
K
K
A
A
L
A
S
A
L
G
E
Y
F
E
R
L
S
T
N
Y
F
F
A
D
FWL
G
-
E
T
I
A
-----
N
G
PFVHYPN
E
K
------
W
F
P
L
T
E
N
D
D
V
P
E
G
L
L
D
D
R
L
R
A
F
Y
D
-----
P
E
N
E
L
T
G
S
M
LIDL
Q
S
G
N
E
D
R
G
-
I
C
G
L
P
F
---
T
R
Q
S
D
N
Q
T
V
Y
I
P
M
N
I
I
G
N
L
Y
V
S
N
G
M
---
S
A
-
G
N
-
T
R
N
E
A
R
V
Q
G
L
S
E
V
F
E
R
Y
V
K
N
R
I
I
A
E
S
I
S
L
P
E
I
P
A
D
V
L
A
R
Y
P
A
V
V
E
A
I
E
T
L
E
A
-
E
G
F
P
I
F
A
Y
D
GSLGG
Q
Y
P
V
I
C
V
V
L
F
N
P
A
NG
T
C
F
A
S
F
G
A
-
H
P
D
------
F
G
V
A
L
E
R
T
V
T
E
L
L
Q
G
R
G
L
K
DLDV
F
T
P
P
T
F
D
D
E
E
V
A
E
H
-
T
-
N
L
E
T
H
F
---------------
I
D
S
S
G
L
I
S
W
D
L
F
--
K
Q
D
-
A
D
-
Y
--
P
FV
D
--
W
N
F
S
G
T
T
E
E
E
F
A
T
L
M
A
I
F
N
K
E
D
K
E
V
Y
I
A
D
-
Y
-
E
-
H
L
G
V
-
Y
A
C
R
I
I
V
P
G
M
S
-
D
I
-
Y
P
---
A
-
E
-
D
L
W
L
-
A
N
N
SM
G
S
H
-
L
R
----
E
T
------------
I
-------
L
S
L
PGSEWE
K
-----
E
D
Y
L
N
L
--------
I
E
Q
L
--
D
E
E
G
F
D
D
F
T
R
V
R
E
L
L
GLATGSDNGW
Y
T
LR
I
G
E
L
K
A
M
L
A
L
A
G
G
D
L
E
Q
A
----
L
V
W
T
E
W
T
M
E
F
N
S
S
V
F
S
P
E
R
A
N
Y
---
Y
---
R
---
C
----
L
Q
T
L
L
L
L
A
Q
E
E
D
R
--
Q
P
L
Q
Y
L
N
A
F
V
R
M
-------
Y
G
A
--
D
------
A
V
E
A
---
A
S
A
A
M
S
G
------
E
A
A
FYG
L
Q
P
V
D
S
D
L
H
A
F
A
A
H
Q
S
L
L
K
A
Y
E
K
L
Q
R
A
K
A
A
F
38
Fugue
41.38
17%
-18
- C6 -
3J6V
-
RT05_BOVIN
E:
[89-430]
---
F
F
T
K
L
TA
D
E
L
W
K
G
A
L
A
E
T
G
A
G
A
R
K
G
R
G
K
R
-----
T
K
R
K
R
R
K
D
L
N
R
G
Q
I
I
-------------------
G
E
G
R
R
---------
G
F
L
-
W
P
G
L
N
A
P
L
M
K
S
---
G
-
A
I
Q
T
-----
I
T
--------
Q
------
R
S
K
E
E
Q
E
K
V
E
A
D
M
-
V
Q
Q
R
E
E
W
D
-------
R
K
R
K
M
K
V
K
R
----
E
R
G
W
S
G
N
S
-
W
---------
G
G
I
S
---
L
G
-----------
P
P
D
P
---
G
P
-----------
N
G
E
T
Y
D
D
F
D
T
R
I
L
E
V
R
N
V
F
N
M
T
A
K
----------------------
E
G
R
K
R
---------
S
V
R
V
L
V
A
V
G
N
G
R
G
--
A
A
G
F
A
I
G
K
-
A
T
E
-----------
R
A
D
A
F
R
K
A
K
N
R
A
V
H
----
Y
L
----------
H
Y
-
I
-
E
R
-----------------------
Y
E
D
H
T
I
Y
H
--
D
I
S
-
L
T
-
F
--
K
--
R
--
T
H
I
K
-------------
M
K
K
Q
P
R
G
----
Y
-
G
-
L
-
R
C
H
R
-
A
I
T
T
I
C
R
L
I
G
I
-
K
-----------
D
M
Y
A
-
K
V
S
--
G
-------------------------------------------------
S
V
N
--------
M
L
S
L
--
T
---
R
G
L
F
Q
G
L
S
R
Q
E
-----------
T
------
H
Q
Q
L
A
D
--
K
K
S
L
H
V
----
V
E
F
-
R
E
E
C
G
P
L
P
I
V
V
A
S
P
Q
G
A
L
---
R
K
D
P
E
---
P
----
E
D
----
E
V
P
D
I
------
K
L
D
W
D
D
V
K
A
V
-------
Q
G
M
--
K
------
R
S
V
W
---
S
G
L
K
R
A
A
------
T
------------------------------------
24
HHSearch
25.68
20%
3
- C8 -
1C96
3
ACON_BOVIN
A:
[153-214]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
---------
A
Y
P
G
V
L
L
I
G
T
D
S
H
--
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
------------
L
K
C
P
K
V
I
G
V
K
L
T
G
S
-
L
-
S
G
W
T
S
P
---------------
K
D
V
I
L
K
V
A
G
I
L
T
--
V
K
G
-
G
T
-
G
--
A
--
I
--
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
----
E
-
I
-
G
-
A
T
T
S
-
V
F
P
Y
N
H
R
M
K
K
Y
-
L
S
-
K
T
---
G
R
A
-
D
I
A
N
-
L
A
D
--
E
F
K
-
D
H
----
L
V
------------
P
-------
D
P
G
------
C
-----
H
Y
D
Q
V
I
--------
E
I
N
L
--
S
---
E
L
K
P
H
I
N
G
P
F
T
----------
P
D
------
L
A
H
P
V
A
--
E
V
G
S
V
A
----
E
K
E
-
G
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
S
S
---
Y
E
D
M
G
---
R
----
S
A
A
V
A
K
Q
A
L
A
H
G
L
--
K
C
K
S
Q
F
T
I
T
P
G
S
-------
E
Q
I
--
R
------
A
T
I
E
---
R
D
G
Y
A
Q
V
------
L
R
D
---
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
---------------
9
PsiBlast_PDB
25.09
27%
-17
- C7 -
3QFY
-
?
A:
[246-337]
------------------------------------------------------
E
A
------
S
-----
V
-
P
R
A
G
K
S
A
D
S
V
A
S
G
W
Y
-
P
I
-
G
S
H
S
V
A
V
T
L
Q
P
---
G
-
E
S
R
D
-----
L
V
--------
Y
------
V
L
G
Y
L
E
N
P
D
E
E
K
W
-
A
D
D
A
-------------------------
H
Q
V
V
N
K
A
-
P
A
H
A
L
L
G
R
F
A
T
S
E
Q
---
V
D
A
A
L
E
A
L
N
S
Y
W
-
T
N
L
L
---
S
T
-
Y
S
-
V
S
S
T
D
E
K
L
D
R
M
V
N
I
W
N
Q
Y
Q
C
M
V
T
F
N
M
S
R
S
A
S
F
F
E
T
G
I
G
R
G
M
G
F
R
D
S
N
Q
D
L
L
G
-
F
V
H
L
I
---------
P
E
R
A
R
E
R
I
I
D
I
A
S
--
T
Q
F
A
D
G
S
A
-
Y
H
Q
Y
Q
P
L
T
K
R
G
N
N
D
I
G
S
G
F
N
D
D
P
L
W
L
I
A
----
G
V
A
A
Y
I
K
E
S
G
D
W
G
I
-
L
-
D
E
P
V
P
F
---------------
D
N
E
P
G
S
E
V
P
L
F
E
--
H
L
T
-
R
S
-
F
--
Q
--
F
--
T
V
Q
N
R
G
P
H
G
L
P
L
I
G
R
A
D
W
N
D
C
L
N
L
----
N
-
C
-
F
-
S
T
T
P
-
G
E
S
F
Q
T
T
E
N
Q
A
-
G
G
-
V
A
---
E
S
V
-
F
I
A
A
-
Q
F
V
--
L
Y
G
-
A
E
----
Y
A
------------
T
-------
L
A
E
------
R
-----
R
G
L
A
D
V
--------
A
T
E
A
--
R
---
K
Y
V
D
E
V
R
A
A
V
L
----------
E
H
------
G
W
D
G
Q
W
--
F
L
R
A
Y
D
----
Y
Y
G
-
N
P
V
G
T
D
A
K
P
E
G
K
I
W
I
E
P
Q
---
G
F
A
V
M
---
A
----
G
I
G
V
G
E
G
P
D
D
A
D
A
--
P
A
V
K
A
L
D
S
V
N
E
M
-------
L
G
T
--
P
------
H
G
L
V
---
L
Q
Y
P
A
Y
T
------
T
Y
Q
---
I
E
L
G
E
V
S
T
Y
P
P
G
Y
K
E
N
---------------
7
PsiBlast_PDB
23.91
27%
-12
- C7 -
2CQS
-
?
A:
[246-337]
------------------------------------------------------
E
A
------
S
-----
V
-
P
R
A
G
K
S
A
D
S
V
A
S
G
W
Y
-
P
I
-
G
S
H
S
V
A
V
T
L
Q
P
---
G
-
E
S
R
D
-----
L
V
--------
Y
------
V
L
G
Y
L
E
N
P
D
E
E
K
W
-
A
D
D
A
-------------------------
H
Q
V
V
N
K
A
-
P
A
H
A
L
L
G
R
F
A
T
S
E
Q
---
V
D
A
A
L
E
A
L
N
S
Y
W
-
T
N
L
L
---
S
T
-
Y
S
-
V
S
S
T
D
E
K
L
D
R
M
V
N
I
W
N
Q
Y
Q
C
M
V
T
F
N
M
S
R
S
A
S
F
F
E
T
G
I
G
R
G
M
G
F
R
D
S
N
Q
D
L
L
G
-
F
V
H
L
I
---------
P
E
R
A
R
E
R
I
I
D
I
A
S
--
T
Q
F
A
D
G
S
A
-
Y
H
Q
Y
Q
P
L
T
K
R
G
N
N
D
I
G
S
G
F
N
D
D
P
L
W
L
I
A
----
G
V
A
A
Y
I
K
E
S
G
D
W
G
I
-
L
-
D
E
P
V
P
F
---------------
D
N
E
P
G
S
E
V
P
L
F
E
--
H
L
T
-
R
S
-
F
--
Q
--
F
--
T
V
Q
N
R
G
P
H
G
L
P
L
I
G
R
A
D
W
N
D
C
L
N
L
----
N
-
C
-
F
-
S
T
T
P
-
G
E
S
F
Q
T
T
E
N
Q
A
-
G
G
-
V
A
---
E
S
V
-
F
I
A
A
-
Q
F
V
--
L
Y
G
-
A
E
----
Y
A
------------
T
-------
L
A
E
------
R
-----
R
G
L
A
D
V
--------
A
T
E
A
--
R
---
K
Y
V
D
E
V
R
A
A
V
L
----------
E
H
------
G
W
D
G
Q
W
--
F
L
R
A
Y
D
----
Y
Y
G
-
N
P
V
G
T
D
A
K
P
E
G
K
I
W
I
E
P
Q
---
G
F
A
V
M
---
A
----
G
I
G
V
G
E
G
P
D
D
A
D
A
--
P
A
V
K
A
L
D
S
V
N
E
M
-------
L
G
T
--
P
------
H
G
L
V
---
L
Q
Y
P
A
Y
T
------
T
Y
Q
---
I
E
L
G
E
V
S
T
Y
P
P
G
Y
K
E
N
---------------
11
PsiBlast_PDB
23.80
27%
-18
- C7 -
3QG0
-
?
A:
[246-337]
------------------------------------------------------
E
A
------
S
-----
V
-
P
R
A
G
K
S
A
D
S
V
A
S
G
W
Y
-
P
I
-
G
S
H
S
V
A
V
T
L
Q
P
---
G
-
E
S
R
D
-----
L
V
--------
Y
------
V
L
G
Y
L
E
N
P
D
E
E
K
W
-
A
D
D
A
-------------------------
H
Q
V
V
N
K
A
-
P
A
H
A
L
L
G
R
F
A
T
S
E
Q
---
V
D
A
A
L
E
A
L
N
S
Y
W
-
T
N
L
L
---
S
T
-
Y
S
-
V
S
S
T
D
E
K
L
D
R
M
V
N
I
W
N
Q
Y
Q
C
M
V
T
F
N
M
S
R
S
A
S
F
F
E
T
G
I
G
R
G
M
G
F
R
D
S
N
Q
D
L
L
G
-
F
V
H
L
I
---------
P
E
R
A
R
E
R
I
I
D
I
A
S
--
T
Q
F
A
D
G
S
A
-
Y
H
Q
Y
Q
P
L
T
K
R
G
N
N
D
I
G
S
G
F
N
D
D
P
L
W
L
I
A
----
G
V
A
A
Y
I
K
E
S
G
D
W
G
I
-
L
-
D
E
P
V
P
F
---------------
D
N
E
P
G
S
E
V
P
L
F
E
--
H
L
T
-
R
S
-
F
--
Q
--
F
--
T
V
Q
N
R
G
P
H
G
L
P
L
I
G
R
A
D
W
N
D
C
L
N
L
----
N
-
C
-
F
-
S
T
T
P
-
G
E
S
F
Q
T
T
E
N
Q
A
-
G
G
-
V
A
---
E
S
V
-
F
I
A
A
-
Q
F
V
--
L
Y
G
-
A
E
----
Y
A
------------
T
-------
L
A
E
------
R
-----
R
G
L
A
D
V
--------
A
T
E
A
--
R
---
K
Y
V
D
E
V
R
A
A
V
L
----------
E
H
------
G
W
D
G
Q
W
--
F
L
R
A
Y
D
----
Y
Y
G
-
N
P
V
G
T
D
A
K
P
E
G
K
I
W
I
E
P
Q
---
G
F
A
V
M
---
A
----
G
I
G
V
G
E
G
P
D
D
A
D
A
--
P
A
V
K
A
L
D
S
V
N
E
M
-------
L
G
T
--
P
------
H
G
L
V
---
L
Q
Y
P
A
Y
T
------
T
Y
Q
---
I
E
L
G
E
V
S
T
Y
P
P
G
Y
K
E
N
---------------
13
PsiBlast_PDB
23.64
27%
-17
- C7 -
3AFJ
-
?
A:
[246-337]
------------------------------------------------------
E
A
------
S
-----
V
-
P
R
A
G
K
S
A
D
S
V
A
S
G
W
Y
-
P
I
-
G
S
H
S
V
A
V
T
L
Q
P
---
G
-
E
S
R
D
-----
L
V
--------
Y
------
V
L
G
Y
L
E
N
P
D
E
E
K
W
-
A
D
D
A
-------------------------
H
Q
V
V
N
K
A
-
P
A
H
A
L
L
G
R
F
A
T
S
E
Q
---
V
D
A
A
L
E
A
L
N
S
Y
W
-
T
N
L
L
---
S
T
-
Y
S
-
V
S
S
T
D
E
K
L
D
R
M
V
N
I
W
N
Q
Y
Q
C
M
V
T
F
N
M
S
R
S
A
S
F
F
E
T
G
I
G
R
G
M
G
F
R
D
S
N
Q
D
L
L
G
-
F
V
H
L
I
---------
P
E
R
A
R
E
R
I
I
D
I
A
S
--
T
Q
F
A
D
G
S
A
-
Y
H
Q
Y
Q
P
L
T
K
R
G
N
N
D
I
G
S
G
F
N
D
D
P
L
W
L
I
A
----
G
V
A
A
Y
I
K
E
S
G
D
W
G
I
-
L
-
D
E
P
V
P
F
---------------
D
N
E
P
G
S
E
V
P
L
F
E
--
H
L
T
-
R
S
-
F
--
Q
--
F
--
T
V
Q
N
R
G
P
H
G
L
P
L
I
G
R
A
D
W
N
D
C
L
N
L
----
N
-
C
-
F
-
S
T
T
P
-
G
E
S
F
Q
T
I
E
N
Q
A
-
G
G
-
V
A
---
E
S
V
-
F
I
A
A
-
Q
F
V
--
L
Y
G
-
A
E
----
Y
A
------------
T
-------
L
A
E
------
R
-----
R
G
L
A
D
V
--------
A
T
E
A
--
R
---
K
Y
V
D
E
V
R
A
A
V
L
----------
E
H
------
G
W
D
G
Q
W
--
F
L
R
A
Y
D
----
Y
Y
G
-
N
P
V
G
T
D
A
K
P
E
G
K
I
W
I
E
P
Q
---
G
F
A
V
M
---
A
----
G
I
G
V
G
E
G
P
D
D
A
D
A
--
P
A
V
K
A
L
D
S
V
N
E
M
-------
L
G
T
--
P
------
H
G
L
V
---
L
Q
Y
P
A
Y
T
------
T
Y
Q
---
I
E
L
G
E
V
S
T
Y
P
P
G
Y
K
E
N
---------------
14
PsiBlast_PDB
23.62
27%
-16
- C7 -
3ACS
-
?
A:
[246-337]
------------------------------------------------------
E
A
------
S
-----
V
-
P
R
A
G
K
S
A
D
S
V
A
S
G
W
Y
-
P
I
-
G
S
H
S
V
A
V
T
L
Q
P
---
G
-
E
S
R
D
-----
L
V
--------
Y
------
V
L
G
Y
L
E
N
P
D
E
E
K
W
-
A
D
D
A
-------------------------
H
Q
V
V
N
K
A
-
P
A
H
A
L
L
G
R
F
A
T
S
E
Q
---
V
D
A
A
L
E
A
L
N
S
Y
W
-
T
N
L
L
---
S
T
-
Y
S
-
V
S
S
T
D
E
K
L
D
R
M
V
N
I
W
N
Q
Y
Q
C
M
V
T
F
N
M
S
R
S
A
S
F
F
E
T
G
I
G
R
G
M
G
F
R
D
S
N
Q
D
L
L
G
-
F
V
H
L
I
---------
P
E
R
A
R
E
R
I
I
D
I
A
S
--
T
Q
F
A
D
G
S
A
-
Y
H
Q
Y
Q
P
L
T
K
R
G
N
N
D
I
G
S
G
F
N
D
D
P
L
W
L
I
A
----
G
V
A
A
Y
I
K
E
S
G
D
W
G
I
-
L
-
D
E
P
V
P
F
---------------
D
N
E
P
G
S
E
V
P
L
F
E
--
H
L
T
-
R
S
-
F
--
Q
--
F
--
T
V
Q
N
R
G
P
H
G
L
P
L
I
G
R
A
D
F
N
D
C
L
N
L
----
N
-
C
-
F
-
S
T
T
P
-
G
E
S
F
Q
T
T
E
N
Q
A
-
G
G
-
V
A
---
E
S
V
-
F
I
A
A
-
Q
F
V
--
L
Y
G
-
A
E
----
Y
A
------------
T
-------
L
A
E
------
R
-----
R
G
L
A
D
V
--------
A
T
E
A
--
R
---
K
Y
V
D
E
V
R
A
A
V
L
----------
E
H
------
G
W
D
G
Q
W
--
F
L
R
A
Y
D
----
Y
Y
G
-
N
P
V
G
T
D
A
K
P
E
G
K
I
W
I
E
P
Q
---
G
F
A
V
M
---
A
----
G
I
G
V
G
E
G
P
D
D
A
D
A
--
P
A
V
K
A
L
D
S
V
N
E
M
-------
L
G
T
--
P
------
H
G
L
V
---
L
Q
Y
P
A
Y
T
------
T
Y
Q
---
I
E
L
G
E
V
S
T
Y
P
P
G
Y
K
E
N
---------------
23
HHSearch
23.60
14%
-11
* C8 *
2B3Y
1
ACOC_HUMAN
A:
[193-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
---------
Y
Y
P
D
-
S
L
V
G
T
D
S
H
--
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
------------
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
-
P
-
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
--
V
A
Q
-
L
S
-
I
--
A
--
D
--
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
----
I
-
T
-
Y
-
L
V
Q
T
-
G
R
D
E
E
K
L
K
Y
I
K
-
K
Y
-
L
Q
---
A
V
G
-
M
F
R
D
-
F
N
D
--
P
S
Q
-
D
P
----
D
F
------------
T
-------
Q
V
V
------
E
-----
L
D
L
K
T
V
--------
V
P
C
C
--
S
---
G
P
K
R
P
Q
D
K
V
A
V
----------
S
D
------
M
K
K
D
F
E
--
S
C
L
G
A
K
----
Q
G
F
-
K
G
F
Q
V
A
P
E
H
H
N
D
H
K
T
F
I
Y
---
D
N
T
E
F
---
T
----
L
A
H
G
S
V
V
I
A
A
I
T
S
--
C
T
N
T
S
N
P
S
V
M
L
G
-------
A
G
L
--
L
------
A
K
K
A
---
V
D
A
G
L
N
V
------
M
P
Y
---
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
---------------
12
PsiBlast_PDB
23.54
27%
-13
- C7 -
3ACT
-
?
A:
[246-337]
------------------------------------------------------
E
A
------
S
-----
V
-
P
R
A
G
K
S
A
D
S
V
A
S
G
W
Y
-
P
I
-
G
S
H
S
V
A
V
T
L
Q
P
---
G
-
E
S
R
D
-----
L
V
--------
Y
------
V
L
G
Y
L
E
N
P
D
E
E
K
W
-
A
D
D
A
-------------------------
H
Q
V
V
N
K
A
-
P
A
H
A
L
L
G
R
F
A
T
S
E
Q
---
V
D
A
A
L
E
A
L
N
S
Y
W
-
T
N
L
L
---
S
T
-
Y
S
-
V
S
S
T
D
E
K
L
D
R
M
V
N
I
W
N
Q
Y
Q
C
M
V
T
F
N
M
S
R
S
A
S
F
F
E
T
G
I
G
R
G
M
G
F
R
D
S
N
Q
D
L
L
G
-
F
V
H
L
I
---------
P
E
R
A
R
E
R
I
I
D
I
A
S
--
T
Q
F
A
D
G
S
A
-
Y
H
Q
Y
Q
P
L
T
K
R
G
N
N
D
I
G
S
G
F
N
D
D
P
L
W
L
I
A
----
G
V
A
A
Y
I
K
E
S
G
D
W
G
I
-
L
-
D
E
P
V
P
F
---------------
D
N
E
P
G
S
E
V
P
L
F
E
--
H
L
T
-
R
S
-
F
--
Q
--
F
--
T
V
Q
N
R
G
P
H
G
L
P
L
I
G
R
A
D
W
N
D
C
L
N
L
----
N
-
C
-
F
-
S
T
T
P
-
G
E
S
F
Q
T
T
E
N
Q
A
-
G
G
-
V
A
---
E
S
V
-
F
I
A
A
-
Q
F
V
--
L
Y
G
-
A
E
----
Y
A
------------
T
-------
L
A
E
------
R
-----
R
G
L
A
D
V
--------
A
T
E
A
--
R
---
K
Y
V
D
E
V
R
A
A
V
L
----------
E
H
------
G
W
D
G
Q
W
--
F
L
R
A
Y
D
----
Y
Y
G
-
N
P
V
G
T
D
A
K
P
E
G
K
I
W
I
E
P
Q
---
G
F
A
V
M
---
A
----
G
I
G
V
G
E
G
P
D
D
A
D
A
--
P
A
V
K
A
L
D
S
V
N
E
M
-------
L
G
T
--
P
------
H
G
L
V
---
L
Q
Y
P
A
Y
T
------
T
Y
Q
---
I
E
L
G
E
V
S
T
Y
P
P
G
Y
K
E
N
---------------