@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0385: (2015-12-01 )
MSNRKDLLSVLDFTVNDVGNIIELAGQYLENKAANGRILENKTVINLFFEDSTRTLTSFEMAAKSLGANVVTLPVKSSSINKGEDLTDMIKTLNAMNPDYIVVRQKSSGIVNMLAKHVSCLLINAGDGSSEHPTQALADYFVISSHKKQIKNLKIVICGDILHSRVARSNIRLLKMFGAKICLVAPPTLICKHFPEVDSIYYSLIEGIKDADVIMLLRLQKERMNSGCFIPSNREYFYLYGLDSQKLLCAKSNAIVMHPGPINRGIEISSDITDHIILQQVEFGLAIRKAVLHYYRPC
Atome Classification :
(23 SA)
.........10........20........30-...--.....--.40........50........60........70...--.-..-..80........90........100.......110........120........130.......140.......150.......160.......170.....-..180....-----...-190-...--.---------.-------..200---.......210.......220.......230.......---240........250.......260.......270--.---.---...-..280.......290......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
N
R
K
D
L
L
S
V
L
D
F
T
V
N
D
V
G
N
I
I
E
L
A
G
Q
Y
L
E
--NKA--AN
G
R
I
--
L
EN
K
T
V
I
N
L
F
FEDSTR
T
L
T
S
F
E
M
A
A
K
SLGA
N
V
V
T
L
P--V-KS-SSINKG
E
D
L
T
D
M
I
K
T
L
NAMNP
D
Y
I
V
V
R
QKSS
G
I
V
-
N
M
L
A
K
H
V
S
C
L
-
L
I
NAGDGSSEH
P
T
Q
A
L
A
D
Y
F
V
I
S
S
H
K
K
QIKN
L
K
I
V
I
C
G
D
I
L
H
S
R
V
A
R
SN
I
R
L
L
KMF-G
A
K
I
C
L
VA
P
-----
P
T
L
-
I
C
K
-HFP--
E
---------
V
-------
D
S
I
Y
Y
---
S
L
I
EGIKD
A
D
V
I
M
L
L
R
L
Q
K
E
RMNS
G
C
F
IPSN
R
E
Y
F
Y
L
---YG-LDS
Q
K
L
L
C
AKS
N
A
I
V
MHPGPINRG
I
E
ISSD
I
--
T
---
D
---
H
I
I
-
L
Q
Q
V
E
F
G
L
A
I
R
K
A
V
L
H
YYRPC
55
HHSearch
97.88
37%
-124
* C7 *
3R7F
7
PYRB_BACSU
A:
[1-291]
---
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
--
G
K
----
T
D
N
Q
--
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
--
G
-
T
S
-
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
-
E
E
L
V
S
Q
V
N
I
P
-
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
-----
S
E
W
-
Q
D
E
-
E
N
T
--------------------
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
---
A
V
S
Q
E
G
Y
L
N
K
---
Y
G
-
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
--
V
---
E
SEK
S
R
I
-
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
2
PsiBlast_PDB
95.53
36%
-119
- C7 -
3R7F
7
PYRB_BACSU
A:
[2-286]
----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
--
G
K
T
--
D
N
Q
----
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
--
G
-
T
S
-
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
-
E
E
L
V
S
Q
V
N
I
P
-
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
-----
S
E
---
W
Q
-
D
E
E
--
N
---------
T
-------
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
---
S
Q
E
G
Y
L
N
K
---
Y
G
-
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
--
V
---
E
SEK
S
R
I
-
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
27
PsiBlast_CBE
95.51
36%
-119
- C7 -
3R7F
8
PYRB_BACSU
B:
[2-286]
----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
--
G
K
T
--
D
N
Q
----
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
--
G
-
T
S
-
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
-
E
E
L
V
S
Q
V
N
I
P
-
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
-----
S
E
---
W
Q
-
D
E
E
--
N
---------
T
-------
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
---
S
Q
E
G
Y
L
N
K
---
Y
G
-
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
--
V
---
E
SEK
S
R
I
-
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
1
PsiBlast_PDB
94.97
36%
-117
- C7 -
3R7D
3
PYRB_BACSU
A:
[2-286]
----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
--
G
K
T
--
D
N
Q
----
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
--
G
-
T
S
-
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
-
E
E
L
V
S
Q
V
N
I
P
-
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
-----
S
E
---
W
Q
-
D
E
E
--
N
---------
T
-------
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
---
S
Q
E
G
Y
L
N
K
---
Y
G
-
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
--
V
---
E
SEK
S
R
I
-
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
26
PsiBlast_CBE
94.70
36%
-113
- C7 -
3R7F
7
PYRB_BACSU
C:
[2-286]
----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
--
G
K
T
--
D
N
Q
----
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
--
G
-
T
S
-
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
-
E
E
L
V
S
Q
V
N
I
P
-
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
-----
S
E
---
W
Q
-
D
E
E
--
N
---------
T
-------
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
---
S
Q
E
G
Y
L
N
K
---
Y
G
-
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
--
V
---
E
SEK
S
R
I
-
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
25
PsiBlast_CBE
94.48
36%
-109
- C7 -
3R7L
3
PYRB_BACSU
B:
[2-286]
----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
--
G
K
T
--
D
N
Q
----
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
--
G
-
T
S
-
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
-
E
E
L
V
S
Q
V
N
I
P
-
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
-----
S
E
---
W
Q
-
D
E
E
--
N
---------
T
-------
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
---
S
Q
E
G
Y
L
N
K
---
Y
G
-
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
--
V
---
E
SEK
S
R
I
-
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-
21
PsiBlast_CBE
94.34
36%
-111
- C7 -
3R7L
3
PYRB_BACSU
F:
[2-286]
----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
--
G
K
T
--
D
N
Q
----
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
--
G
-
T
S
-
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
-
E
E
L
V
S
Q
V
N
I
P
-
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
-----
S
E
---
W
Q
-
D
E
E
--
N
---------
T
-------
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
---
S
Q
E
G
Y
L
N
K
---
Y
G
-
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
--
V
---
E
SEK
S
R
I
-
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-
24
PsiBlast_CBE
94.15
36%
-111
- C7 -
3R7L
3
PYRB_BACSU
C:
[2-286]
----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
--
G
K
T
--
D
N
Q
----
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
--
G
-
T
S
-
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
-
E
E
L
V
S
Q
V
N
I
P
-
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
-----
S
E
---
W
Q
-
D
E
E
--
N
---------
T
-------
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
---
S
Q
E
G
Y
L
N
K
---
Y
G
-
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
--
V
---
E
SEK
S
R
I
-
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-
6
PsiBlast_PDB
93.75
37%
-133
- C7 -
4BJH
14
PYRB_AQUAE
B:
[33-319]
----
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
--
G
K
E
--
E
T
I
K
A
------
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
S
--
G
-
S
E
-
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
P
Y
K
E
I
V
K
S
L
N
L
R
-
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
-----
K
T
L
-
I
P
R
-
D
V
E
VF
K
---------
V
-------
D
-
V
F
D
---
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
-
Y
I
P
S
E
S
S
Y
F
K
Q
---
F
G
-
L
T
K
E
R
F
E
K
V
K
---
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
--
V
YTE
K
---
S
L
I
-
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
F
L
W
T
-
3
PsiBlast_PDB
93.33
36%
-112
- C7 -
3R7L
3
PYRB_BACSU
A:
[2-286]
----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
--
G
K
T
--
D
N
Q
----
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
--
G
-
T
S
-
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
-
E
E
L
V
S
Q
V
N
I
P
-
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
-----
S
E
---
W
Q
-
D
E
E
--
N
---------
T
-------
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
---
S
Q
E
G
Y
L
N
K
---
Y
G
-
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
--
V
---
E
SEK
S
R
I
-
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-
5
PsiBlast_PDB
93.31
37%
-127
- C7 -
3D6N
1
PYRB_AQUAE
B:
[2-288]
----
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
--
G
K
E
--
E
T
I
K
A
------
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
S
--
G
-
S
E
-
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
P
Y
K
E
I
V
K
S
L
N
L
R
-
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
-----
K
T
L
-
I
P
R
-
D
V
E
VF
K
---------
V
-------
D
-
V
F
D
---
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
-
Y
I
P
S
E
S
S
Y
F
K
Q
---
F
G
-
L
T
K
E
R
F
E
K
V
K
---
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
--
V
YTE
K
---
S
L
I
-
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
F
L
W
T
-
23
PsiBlast_CBE
93.15
36%
-113
- C7 -
3R7L
3
PYRB_BACSU
D:
[2-286]
----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
--
G
K
T
--
D
N
Q
----
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
--
G
-
T
S
-
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
-
E
E
L
V
S
Q
V
N
I
P
-
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
-----
S
E
---
W
Q
-
D
E
E
--
N
---------
T
-------
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
---
S
Q
E
G
Y
L
N
K
---
Y
G
-
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
--
V
---
E
SEK
S
R
I
-
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-
22
PsiBlast_CBE
92.97
36%
-109
- C7 -
3R7L
3
PYRB_BACSU
E:
[2-286]
----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
--
G
K
T
--
D
N
Q
----
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
--
G
-
T
S
-
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
-
E
E
L
V
S
Q
V
N
I
P
-
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
-----
S
E
---
W
Q
-
D
E
E
--
N
---------
T
-------
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
---
S
Q
E
G
Y
L
N
K
---
Y
G
-
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
--
V
---
E
SEK
S
R
I
-
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-
29
PsiBlast_CBE
92.59
36%
-115
- C7 -
3R7D
2
PYRB_BACSU
B:
[2-286]
----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
--
G
K
T
--
D
N
Q
----
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
--
G
-
T
S
-
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
-
E
E
L
V
S
Q
V
N
I
P
-
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
-----
S
E
---
W
Q
-
D
E
E
--
N
---------
T
-------
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
---
S
Q
E
G
Y
L
N
K
---
Y
G
-
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
--
V
---
E
SEK
S
R
I
-
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
28
PsiBlast_CBE
92.42
36%
-116
- C7 -
3R7D
4
PYRB_BACSU
C:
[2-286]
----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
--
G
K
T
--
D
N
Q
----
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
--
G
-
T
S
-
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
-
E
E
L
V
S
Q
V
N
I
P
-
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
-----
S
E
---
W
Q
-
D
E
E
--
N
---------
T
-------
F
G
T
Y
V
---
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
---
S
Q
E
G
Y
L
N
K
---
Y
G
-
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
--
V
---
E
SEK
S
R
I
-
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
52
PsiBlast_CBE
89.81
32%
-127
- C7 -
2RGW
1
PYRB_METJA
C:
[2-296]
----
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
M
E
E
LL
N
T
K
--
R
P
L
K
L
--
L
E
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D-
L
-
K
S
-
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
-
R
L
A
S
E
Y
S
Q
V
P
-
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
KELRL
P
K
D
-
I
I
E
-
D
L
K
--
A
---------
K
-------
N
I
K
F
Y
EKE
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
------
P
D
P
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
G
K
K
F
I
I
M
H
P
L
P
--
R
V
D
E
I
D
Y
D
V
--
D
---
D
LPQ
A
K
Y
-
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
53
PsiBlast_CBE
89.67
32%
-130
- C7 -
2RGW
1
PYRB_METJA
B:
[2-296]
----
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
M
E
E
LL
N
T
K
--
R
P
L
K
L
--
L
E
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D-
L
-
K
S
-
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
-
R
L
A
S
E
Y
S
Q
V
P
-
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
KELRL
P
K
D
-
I
I
E
-
D
L
K
--
A
---------
K
-------
N
I
K
F
Y
EKE
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
------
P
D
P
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
G
K
K
F
I
I
M
H
P
L
P
--
R
V
D
E
I
D
Y
D
V
--
D
---
D
LPQ
A
K
Y
-
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
49
PsiBlast_CBE
89.66
32%
-129
- C7 -
2RGW
1
PYRB_METJA
F:
[2-296]
----
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
M
E
E
LL
N
T
K
--
R
P
L
K
L
--
L
E
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D-
L
-
K
S
-
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
-
R
L
A
S
E
Y
S
Q
V
P
-
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
KELRL
P
K
D
-
I
I
E
-
D
L
K
--
A
---------
K
-------
N
I
K
F
Y
EKE
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
------
P
D
P
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
G
K
K
F
I
I
M
H
P
L
P
--
R
V
D
E
I
D
Y
D
V
--
D
---
D
LPQ
A
K
Y
-
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
50
PsiBlast_CBE
89.40
32%
-129
- C7 -
2RGW
1
PYRB_METJA
E:
[2-296]
----
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
M
E
E
LL
N
T
K
--
R
P
L
K
L
--
L
E
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D-
L
-
K
S
-
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
-
R
L
A
S
E
Y
S
Q
V
P
-
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
KELRL
P
K
D
-
I
I
E
-
D
L
K
--
A
---------
K
-------
N
I
K
F
Y
EKE
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
------
P
D
P
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
G
K
K
F
I
I
M
H
P
L
P
--
R
V
D
E
I
D
Y
D
V
--
D
---
D
LPQ
A
K
Y
-
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
40
PsiBlast_CBE
89.18
32%
-123
- C7 -
3E2P
1
PYRB_METJA
K:
[2-296]
----
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
M
E
E
LL
N
T
K
--
R
P
L
K
L
--
L
E
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D-
L
-
K
S
-
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
-
R
L
A
S
E
Y
S
Q
V
P
-
I
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
KELRL
P
K
D
-
I
I
E
-
D
L
K
--
A
---------
K
-------
N
I
K
F
Y
EKE
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
------
P
D
P
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
G
K
K
F
I
I
M
H
P
L
P
--
R
V
D
E
I
D
Y
D
V
--
D
---
D
LPQ
A
K
Y
-
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
10
PsiBlast_PDB
88.78
32%
-116
- C7 -
1ML4
1
PYRB_PYRAB
A:
[6-301]
----
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
R
L
E
R
--
E
L
K
--
E
K
G
Q
L
EY
A
K
G
K
I
L
A
T
L
F
F
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
A
--
E
-
A
S
T
S
S
V
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
C
-
D
V
I
V
I
R
H
P
K
E
G
A
A
-
R
L
A
A
E
V
A
E
V
P
-
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
L
Y
L
I
S
P
-----
E
L
L
R
M
P
R
-
H
I
V
--
E
E
L
R
E
K
GMK
V
V
-------
E
T
T
-----
T
L
E
D
V
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
F
------
P
D
E
Q
E
Y
L
K
V
KGS
Y
Q
-
V
N
L
K
V
L
E
K
A
K
D
E
L
R
I
M
H
P
L
P
R
V
D
E
I
H
P
E
V
D
N
--
T
---
K
---
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
G
V
14
PsiBlast_PDB
86.30
30%
-116
- C7 -
1EKX
2
PYRB_ECOLI
A:
[7-301]
---
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
--
N
P
----
Q
P
E
L
--
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
DS
A
-
N
T
-
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
-
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
DALAM
P
Q
Y
-
I
L
D
-
M
L
D
--
E
K
G
I
------
A
-------
W
S
L
H
S
---
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
--------
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
DK
T
---
P
---
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
59
HHSearch
84.99
32%
-121
- C7 -
1ML4
1
PYRB_PYRAB
A:
[2-307]
D
W
K
G
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
R
L
E
R
--
E
L
K
E
K
G
Q
L
E
Y
--
A
K
G
K
I
L
A
T
L
F
F
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
A
--
E
A
S
T
-
S
S
V
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
V
I
V
I
R
H
P
K
E
G
A
A
-
R
L
A
A
E
V
A
E
V
P
-
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
L
Y
L
I
S
P
-----
E
L
L
-
R
M
P
R
H
I
V
--
E
---------
E
L
R
E
K
GMK
V
V
E
T
T
---
T
L
E
D
V
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
-
E
--
Q
E
Y
L
K
V
K
G
S
---
Y
Q
-
V
N
L
K
V
L
E
K
A
K
D
E
L
R
I
M
H
P
L
P
R
V
--
D
E
I
H
P
E
V
--
D
---
N
TKH
A
I
Y
-
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
G
V