@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0503: (2015-12-02 )
MIPRYSRKEISAIWEENNKFNIWLKIERLACEAQAKLGVIPSNVAKRLSGAITFDVERINEIESTVKHDVIAFLTYIAEKVGVDVRYLHYGMTSSDVLDTCFAVQLKESCNILLENLKNLLAALKKKAEDYKGTICVGRSHGMHAEPTTLGLKFTRFYAEFKRSYQRLINAQKEISICKISGAVGNFANVDPFVEEYVAKGMELVPETISSQVIPRDRHAMFFSVLGVIASSMENVAVEIRHLQRTEIAEIAEYFSTGQKGSSAMPHKCNPILSENLTGLSRLIRSYVSPALENVVLWHERDISHSSVERCIAPDACILMDFALVRLTDLIDKLAINKENIEKNLNSSKGLIFSQRILLELVNSGLTREEAYKIIQGNAMKVKQNNSDFLFELKQDRSLLEVINSEKLESLFDLKYYTKYVDHIYKKVFD
Atome Classification :
(20 SA)
-----.........10........20........30.......--.-40........50.-.---.-----.....60-------.........70........80-.-.----...----....90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190---.------.----------..---....200..-...-.--------.210........220.......230.......240.......250.......260.......270.......280.......290.-..-....300.......310.......320.......330.......340.......350.......360.......370...----..---..380.....------.------.-390...----....400..--.....410-......----.420.......430------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----MIPRY
S
R
K
E
I
S
A
I
WEENN
K
F
N
I
W
L
K
I
E
R
L
A
C
E
A
QAKLG--V-
I
P
S
N
V
A
K
RLSG
A
I
-
T
---
F
-----
D
V
E
R
I
N
--------
E
I
E
S
T
V
K
H
D
V
I
A
F
L
T
Y
I
A
E
K
--V-G----V
D
V
----
R
Y
L
HYGM
T
S
S
D
V
L
D
T
C
F
A
V
Q
L
K
E
S
C
N
I
L
L
E
N
L
K
N
L
L
A
A
L
K
K
K
A
E
DYK
G
T
I
C
V
GRSHGMHAEPTTL
G
L
K
F
T
R
F
Y
A
E
F
K
R
S
Y
Q
R
L
INAQK
E
I
S
I
C
K
ISGAVGNFANV
D
----
P
------
F
----------
V
E
---
E
Y
V
A
K
G
M
E
L
-
V
P
E
-
T
--------
I
S-SQVIPR
D
R
H
A
M
F
F
S
V
L
G
V
I
A
S
S
M
E
N
V
A
V
E
I
R
H
L
Q
R
T
E
I
A
E
I
A
E
Y
F
STGQKGSSAMPHKCN
P
I
L
S
E
N
L
T
G
L
S
R
L
I
R
S
Y
V
S
P
A
L
E
-
N
V
-
V
L
W
HERDI
S
H
S
S
V
E
R
CIAP
D
A
C
I
L
M
D
F
A
L
V
R
L
T
D
L
I
D
K
LAI
N
K
E
N
I
E
K
NLNSSKG
L
I
F
S
Q
R
I
L
L
E
L
V
NSGL
T
R
E
E
A
Y
K
I
I----QG---
N
A
M
K
V
KQNNS------
D
------
F
-
L
F
E
L
K
Q----
D
R
S
L
L
E
V
I
N
--
S
E
K
L
E
S
L
F
-
D
L
K
Y
Y
T
----
K
Y
V
D
H
I
Y
K
K
VFD--------------
24
HHSearch
99.81
49%
-101
- C4 -
1C3C
-
PUR8_THEMA
A:
[3-429]
-------
E
R
Y
S
L
S
P
M
K
D
L
W
T
E
E
A
K
Y
R
R
W
L
E
V
E
L
A
V
T
R
A
Y
E
E
L
G
--
M
-
I
P
K
G
V
T
E
R
I
R
N
N
A
-
K
---
I
-----
D
V
E
L
F
K
--------
K
I
E
E
K
T
N
H
D
V
V
A
F
V
E
G
I
G
S
M
--
I
-
G
----
E
D
S
----
R
F
F
H
Y
G
L
T
S
S
D
V
L
D
T
A
N
S
L
A
L
V
E
A
G
K
I
L
L
E
S
L
K
E
F
C
D
V
L
W
E
V
A
N
R
Y
K
H
T
P
T
I
G
R
T
H
G
V
H
A
E
P
T
S
F
G
L
K
V
L
G
W
Y
S
E
M
K
R
N
V
Q
R
L
E
R
A
I
E
E
V
S
Y
G
K
I
S
G
A
V
G
N
Y
A
N
V
P
----
P
------
E
----------
V
E
---
E
K
A
L
S
Y
L
G
L
-
K
P
E
-
P
--------
V
S
-
T
Q
V
V
P
R
D
R
H
A
F
Y
L
S
T
L
A
I
V
A
A
G
I
E
R
I
A
V
E
I
R
H
L
Q
R
T
E
V
L
E
V
E
E
P
F
R
K
-----
S
A
M
P
H
K
K
N
P
I
T
C
E
R
L
T
G
L
S
R
M
M
R
A
Y
V
D
P
S
L
E
-
N
I
-
A
L
W
H
E
R
D
I
S
H
S
S
V
E
R
Y
V
F
P
D
A
T
Q
T
L
Y
Y
M
I
V
T
A
T
N
V
V
R
N
M
K
V
N
E
E
R
M
K
K
N
I
D
L
T
K
G
L
V
F
S
Q
R
V
L
L
K
L
I
E
K
G
L
T
R
K
E
A
Y
D
I
V
----
Q
R
---
N
A
L
K
T
W
N
S
E
K
------
H
------
F
-
L
E
Y
L
L
E
----
D
E
E
V
K
K
L
V
T
--
K
E
E
L
E
E
L
F
-
D
I
S
Y
Y
L
----
K
H
V
D
H
I
F
E
R
F
E
K
--------------
2
PsiBlast_PDB
99.65
49%
-101
- C4 -
1C3C
-
PUR8_THEMA
A:
[2-427]
------
V
E
R
Y
S
L
S
P
M
K
D
L
W
T
E
E
A
K
Y
R
R
W
L
E
V
E
L
A
V
T
R
A
Y
E
E
L
G
--
M
-
I
P
K
G
V
T
E
R
I
R
N
N
A
-
K
---
I
-----
D
V
E
L
F
K
--------
K
I
E
E
K
T
N
H
D
V
V
A
F
V
E
G
I
G
S
M
--
I
-
G
----
E
D
S
----
R
F
F
H
Y
G
L
T
S
S
D
V
L
D
T
A
N
S
L
A
L
V
E
A
G
K
I
L
L
E
S
L
K
E
F
C
D
V
L
W
E
V
A
N
R
Y
K
H
T
P
T
I
G
R
T
H
G
V
H
A
E
P
T
S
F
G
L
K
V
L
G
W
Y
S
E
M
K
R
N
V
Q
R
L
E
R
A
I
E
E
V
S
Y
G
K
I
S
G
A
V
G
N
Y
A
N
V
P
----
P
------
E
----------
V
E
---
E
K
A
L
S
Y
L
G
L
-
K
P
E
-
P
--------
V
S
-
T
Q
V
V
P
R
D
R
H
A
F
Y
L
S
T
L
A
I
V
A
A
G
I
E
R
I
A
V
E
I
R
H
L
Q
R
T
E
V
L
E
V
E
E
P
F
R
K
-----
S
A
M
P
H
K
K
N
P
I
T
C
E
R
L
T
G
L
S
R
M
M
R
A
Y
V
D
P
S
L
E
-
N
I
-
A
L
W
H
E
R
D
I
S
H
S
S
V
E
R
Y
V
F
P
D
A
T
Q
T
L
Y
Y
M
I
V
T
A
T
N
V
V
R
N
M
K
V
N
E
E
R
M
K
K
N
I
D
L
T
K
G
L
V
F
S
Q
R
V
L
L
K
L
I
E
K
G
L
T
R
K
E
A
Y
D
I
V
----
Q
R
---
N
A
L
K
T
W
N
S
E
K
------
H
------
F
-
L
E
Y
L
L
E
----
D
E
E
V
K
K
L
V
T
--
K
E
E
L
E
E
L
F
-
D
I
S
Y
Y
L
----
K
H
V
D
H
I
F
E
R
F
E
K
--------------
21
PsiBlast_CBE
99.06
49%
-102
- C4 -
1C3U
2
PUR8_THEMA
B:
[2-427]
------
V
E
R
Y
S
L
S
P
M
K
D
L
W
T
E
E
A
K
Y
R
R
W
L
E
V
E
L
A
V
T
R
A
Y
E
E
L
G
--
M
-
I
P
K
G
V
T
E
R
I
R
N
N
A
-
K
---
I
-----
D
V
E
L
F
K
--------
K
I
E
E
K
T
N
H
D
V
V
A
F
V
E
G
I
G
S
M
--
I
-
G
----
E
D
S
----
R
F
F
H
Y
G
L
T
S
S
D
V
L
D
T
A
N
S
L
A
L
V
E
A
G
K
I
L
L
E
S
L
K
E
F
C
D
V
L
W
E
V
A
N
R
Y
K
H
T
P
T
I
G
R
T
H
G
V
H
A
E
P
T
S
F
G
L
K
V
L
G
W
Y
S
E
M
K
R
N
V
Q
R
L
E
R
A
I
E
E
V
S
Y
G
K
I
S
G
A
V
G
N
Y
A
N
V
P
----
P
------
E
----------
V
E
---
E
K
A
L
S
Y
L
G
L
-
K
P
E
-
P
--------
V
S
-
T
Q
V
V
P
R
D
R
H
A
F
Y
L
S
T
L
A
I
V
A
A
G
I
E
R
I
A
V
E
I
R
H
L
Q
R
T
E
V
L
E
V
E
E
P
F
R
------
S
A
M
P
H
K
K
N
P
I
T
C
E
R
L
T
G
L
S
R
M
M
R
A
Y
V
D
P
S
L
E
-
N
I
-
A
L
W
H
E
R
D
I
S
H
S
S
V
E
R
Y
V
F
P
D
A
T
Q
T
L
Y
Y
M
I
V
T
A
T
N
V
V
R
N
M
K
V
N
E
E
R
M
K
K
N
I
D
L
T
K
G
L
V
F
S
Q
R
V
L
L
K
L
I
E
K
G
L
T
R
K
E
A
Y
D
I
V
----
Q
R
---
N
A
L
K
T
W
N
S
E
K
------
H
------
F
-
L
E
Y
L
L
E
----
D
E
E
V
K
K
L
V
T
--
K
E
E
L
E
E
L
F
-
D
I
S
Y
Y
L
----
K
H
V
D
H
I
F
E
R
F
E
K
--------------
1
PsiBlast_PDB
98.60
49%
-102
- C4 -
1C3U
2
PUR8_THEMA
A:
[2-427]
------
V
E
R
Y
S
L
S
P
M
K
D
L
W
T
E
E
A
K
Y
R
R
W
L
E
V
E
L
A
V
T
R
A
Y
E
E
L
G
--
M
-
I
P
K
G
V
T
E
R
I
R
N
N
A
-
K
---
I
-----
D
V
E
L
F
K
--------
K
I
E
E
K
T
N
H
D
V
V
A
F
V
E
G
I
G
S
M
--
I
-
G
----
E
D
S
----
R
F
F
H
Y
G
L
T
S
S
D
V
L
D
T
A
N
S
L
A
L
V
E
A
G
K
I
L
L
E
S
L
K
E
F
C
D
V
L
W
E
V
A
N
R
Y
K
H
T
P
T
I
G
R
T
H
G
V
H
A
E
P
T
S
F
G
L
K
V
L
G
W
Y
S
E
M
K
R
N
V
Q
R
L
E
R
A
I
E
E
V
S
Y
G
K
I
S
G
A
V
G
N
Y
A
N
V
P
----
P
------
E
----------
V
E
---
E
K
A
L
S
Y
L
G
L
-
K
P
E
-
P
--------
V
S
-
T
Q
V
V
P
R
D
R
H
A
F
Y
L
S
T
L
A
I
V
A
A
G
I
E
R
I
A
V
E
I
R
H
L
Q
R
T
E
V
L
E
V
E
E
P
F
R
------
S
A
M
P
H
K
K
N
P
I
T
C
E
R
L
T
G
L
S
R
M
M
R
A
Y
V
D
P
S
L
E
-
N
I
-
A
L
W
H
E
R
D
I
S
H
S
S
V
E
R
Y
V
F
P
D
A
T
Q
T
L
Y
Y
M
I
V
T
A
T
N
V
V
R
N
M
K
V
N
E
E
R
M
K
K
N
I
D
L
T
K
G
L
V
F
S
Q
R
V
L
L
K
L
I
E
K
G
L
T
R
K
E
A
Y
D
I
V
----
Q
R
---
N
A
L
K
T
W
N
S
E
K
------
H
------
F
-
L
E
Y
L
L
E
----
D
E
E
V
K
K
L
V
T
--
K
E
E
L
E
E
L
F
-
D
I
S
Y
Y
L
----
K
H
V
D
H
I
F
E
R
F
E
K
--------------
25
HHSearch
97.62
46%
-102
- C4 -
2PFM
3
?
A:
[11-440]
------
I
S
R
Y
T
R
P
E
M
G
A
I
W
T
E
E
N
K
F
K
A
W
L
E
V
E
I
L
A
C
E
A
W
A
E
L
G
--
D
-
I
P
K
E
D
V
K
K
I
R
E
H
A
-
S
---
F
-----
D
I
D
R
I
Y
--------
E
I
E
K
E
T
R
H
D
V
V
A
F
T
R
A
V
S
E
T
PA
L
-
G
----
E
E
R
----
K
W
V
H
Y
G
L
T
S
T
D
V
V
D
T
A
L
S
Y
I
L
K
Q
A
N
E
I
I
L
K
D
L
E
N
F
V
S
I
L
A
N
K
A
K
E
H
K
Y
T
I
M
M
G
R
T
H
G
V
H
A
E
P
T
T
F
G
L
K
L
G
L
W
Y
E
E
M
K
R
N
V
E
R
F
K
Q
A
A
N
T
V
R
V
G
K
L
S
G
A
V
G
T
Y
A
N
I
D
----
P
------
F
----------
V
E
---
K
Y
V
C
E
N
L
G
L
-
E
A
A
-
P
--------
I
S
-
T
Q
T
L
Q
R
D
R
H
A
H
Y
M
S
T
L
A
L
I
A
T
S
I
E
K
M
A
V
E
I
R
G
L
Q
K
S
E
T
R
E
V
E
E
A
F
A
K
G
Q
K
G
S
S
A
M
P
H
K
R
N
P
I
G
S
E
N
M
T
G
L
A
R
V
I
R
G
Y
M
M
T
A
Y
E
-
N
V
-
P
L
W
H
E
R
D
I
S
H
S
S
A
E
R
V
I
L
P
D
A
T
I
A
L
N
Y
M
L
N
R
F
G
N
I
V
K
N
L
T
V
Y
P
E
N
M
K
R
N
M
T
R
T
Y
G
L
I
Y
S
Q
R
V
M
L
T
L
I
D
K
G
M
V
R
E
E
A
Y
D
I
V
----
Q
P
---
K
A
M
E
A
W
E
T
Q
V
------
Q
------
F
-
K
E
L
V
E
A
----
D
E
R
I
T
S
K
L
T
--
Q
E
E
I
N
E
C
F
-
N
Y
E
H
H
M
----
Q
H
V
D
T
I
F
E
R
L
G
L
--------------
5
PsiBlast_PDB
97.62
46%
-102
- C4 -
2PFM
3
?
A:
[11-439]
------
I
S
R
Y
T
R
P
E
M
G
A
I
W
T
E
E
N
K
F
K
A
W
L
E
V
E
I
L
A
C
E
A
W
A
E
L
G
--
D
-
I
P
K
E
D
V
K
K
I
R
E
H
A
-
S
---
F
-----
D
I
D
R
I
Y
--------
E
I
E
K
E
T
R
H
D
V
V
A
F
T
R
A
V
S
E
T
PA
L
-
G
----
E
E
R
----
K
W
V
H
Y
G
L
T
S
T
D
V
V
D
T
A
L
S
Y
I
L
K
Q
A
N
E
I
I
L
K
D
L
E
N
F
V
S
I
L
A
N
K
A
K
E
H
K
Y
T
I
M
M
G
R
T
H
G
V
H
A
E
P
T
T
F
G
L
K
L
G
L
W
Y
E
E
M
K
R
N
V
E
R
F
K
Q
A
A
N
T
V
R
V
G
K
L
S
G
A
V
G
T
Y
A
N
I
D
----
P
------
F
----------
V
E
---
K
Y
V
C
E
N
L
G
L
-
E
A
A
-
P
--------
I
S
-
T
Q
T
L
Q
R
D
R
H
A
H
Y
M
S
T
L
A
L
I
A
T
S
I
E
K
M
A
V
E
I
R
G
L
Q
K
S
E
T
R
E
V
E
E
A
F
A
K
G
Q
K
G
S
S
A
M
P
H
K
R
N
P
I
G
S
E
N
M
T
G
L
A
R
V
I
R
G
Y
M
M
T
A
Y
E
-
N
V
-
P
L
W
H
E
R
D
I
S
H
S
S
A
E
R
V
I
L
P
D
A
T
I
A
L
N
Y
M
L
N
R
F
G
N
I
V
K
N
L
T
V
Y
P
E
N
M
K
R
N
M
T
R
T
Y
G
L
I
Y
S
Q
R
V
M
L
T
L
I
D
K
G
M
V
R
E
E
A
Y
D
I
V
----
Q
P
---
K
A
M
E
A
W
E
T
Q
V
------
Q
------
F
-
K
E
L
V
E
A
----
D
E
R
I
T
S
K
L
T
--
Q
E
E
I
N
E
C
F
-
N
Y
E
H
H
M
----
Q
H
V
D
T
I
F
E
R
L
G
L
--------------
22
PsiBlast_CBE
97.58
46%
-101
- C4 -
2PFM
2
?
B:
[11-439]
------
I
S
R
Y
T
R
P
E
M
G
A
I
W
T
E
E
N
K
F
K
A
W
L
E
V
E
I
L
A
C
E
A
W
A
E
L
G
--
D
-
I
P
K
E
D
V
K
K
I
R
E
H
A
-
S
---
F
-----
D
I
D
R
I
Y
--------
E
I
E
K
E
T
R
H
D
V
V
A
F
T
R
A
V
S
E
T
PA
L
-
G
----
E
E
R
----
K
W
V
H
Y
G
L
T
S
T
D
V
V
D
T
A
L
S
Y
I
L
K
Q
A
N
E
I
I
L
K
D
L
E
N
F
V
S
I
L
A
N
K
A
K
E
H
K
Y
T
I
M
M
G
R
T
H
G
V
H
A
E
P
T
T
F
G
L
K
L
G
L
W
Y
E
E
M
K
R
N
V
E
R
F
K
Q
A
A
N
T
V
R
V
G
K
L
S
G
A
V
G
T
Y
A
N
I
D
----
P
------
F
----------
V
E
---
K
Y
V
C
E
N
L
G
L
-
E
A
A
-
P
--------
I
S
-
T
Q
T
L
Q
R
D
R
H
A
H
Y
M
S
T
L
A
L
I
A
T
S
I
E
K
M
A
V
E
I
R
G
L
Q
K
S
E
T
R
E
V
E
E
A
F
A
K
G
Q
K
G
S
S
A
M
P
H
K
R
N
P
I
G
S
E
N
M
T
G
L
A
R
V
I
R
G
Y
M
M
T
A
Y
E
-
N
V
-
P
L
W
H
E
R
D
I
S
H
S
S
A
E
R
V
I
L
P
D
A
T
I
A
L
N
Y
M
L
N
R
F
G
N
I
V
K
N
L
T
V
Y
P
E
N
M
K
R
N
M
T
R
T
Y
G
L
I
Y
S
Q
R
V
M
L
T
L
I
D
K
G
M
V
R
E
E
A
Y
D
I
V
----
Q
P
---
K
A
M
E
A
W
E
T
Q
V
------
Q
------
F
-
K
E
L
V
E
A
----
D
E
R
I
T
S
K
L
T
--
Q
E
E
I
N
E
C
F
-
N
Y
E
H
H
M
----
Q
H
V
D
T
I
F
E
R
L
G
L
--------------
4
PsiBlast_PDB
94.48
46%
-95
- C4 -
2X75
4
PUR8_STAAW
A:
[2-427]
------
I
E
R
Y
S
R
E
E
M
S
N
I
W
T
D
Q
N
R
Y
E
A
W
L
E
V
E
I
L
A
C
E
A
W
S
E
L
G
--
H
-
I
P
K
A
D
V
Q
K
I
R
Q
N
A
-
K
---
V
-----
N
V
E
R
A
Q
--------
E
I
E
Q
E
T
R
H
D
V
V
A
F
T
R
Q
V
S
E
T
--
L
-
G
----
E
E
R
----
K
W
V
H
Y
G
L
T
S
T
D
V
V
D
T
A
L
S
F
V
I
K
Q
A
N
D
I
I
E
K
D
L
E
R
F
I
D
V
L
A
E
K
A
K
N
Y
K
Y
T
L
M
M
G
R
T
H
G
V
H
A
E
P
T
T
F
G
V
K
M
A
L
W
Y
T
E
M
Q
R
N
L
Q
R
F
K
Q
V
R
E
E
I
E
V
G
K
M
S
G
A
V
G
T
F
A
N
I
P
----
P
------
E
----------
I
E
---
S
Y
V
C
K
H
L
G
I
-
G
T
A
-
P
--------
V
S
-
T
Q
T
L
Q
R
D
R
H
A
Y
Y
I
A
T
L
A
L
I
A
T
S
L
E
K
F
A
V
E
I
R
N
L
Q
K
T
E
T
R
E
V
E
E
A
F
A
K
G
Q
K
G
S
S
A
M
P
H
K
R
N
P
I
G
S
E
N
I
T
G
I
S
R
V
I
R
G
Y
I
T
T
A
Y
E
-
N
V
-
P
L
W
H
E
R
D
I
S
H
S
S
A
E
R
I
M
L
P
D
V
T
I
A
L
D
Y
A
L
N
R
F
T
N
I
V
D
R
L
T
V
F
E
D
N
M
R
N
N
I
D
K
T
F
G
L
I
F
S
Q
R
V
L
L
A
L
I
N
K
G
M
V
R
E
E
A
Y
D
K
V
----
Q
P
---
K
A
M
I
S
W
E
T
K
T
------
P
------
F
-
R
E
L
I
E
Q
----
D
E
S
I
T
---
T
--
K
E
E
L
D
E
C
F
-
D
P
K
H
H
L
----
N
Q
V
D
T
I
F
E
R
A
G
L
--------------
23
PsiBlast_CBE
92.70
41%
-94
- C4 -
4EEI
17
?
B:
[1-428]
-----
M
I
K
R
Y
D
V
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
E
D
-
R
--
M
-
V
P
K
G
T
A
A
E
I
R
A
R
A
-
Q
---
I
-----
R
P
E
R
V
D
--------
E
I
E
K
V
T
K
H
D
I
I
A
F
C
T
S
I
A
E
Q
--
F
-
T
----
A
E
T
G---
K
F
F
H
F
G
V
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
A
L
C
D
S
L
L
T
K
A
E
E
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
L
K
D
F
Q
K
D
G
L
T
V
Q
F
S
G
A
V
G
N
Y
C
I
L
T
----
T
------
E
----------
D
E
---
K
K
A
A
D
I
L
G
L
-
P
V
E
-
E
--------
V
S
-
T
Q
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
G
F
------------
K
K
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
R
S
H
V
S
I
A
L
E
-
N
C
-
V
L
W
H
E
R
D
I
S
H
S
S
A
E
R
F
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
T
I
D
N
L
V
V
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
S
S
F
Y
L
H
F
L
V
A
N
T
P
F
M
R
E
D
C
Y
K
I
V
----
Q
Q
---
V
A
F
D
L
---
E
S
-------------
F
-
S
K
K
L
Q
K
VMHD
E
H
N
I
I
L
D
I
P
--
E
M
D
F
E
G
I
---
K
K
T
Y
L
----
K
E
I
D
H
V
F
D
R
S
V
K
--------------
6
PsiBlast_PDB
92.28
41%
-96
- C4 -
4EEI
12
?
A:
[1-428]
-----
M
I
K
R
Y
D
V
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
E
D
-
R
--
M
-
V
P
K
G
T
A
A
E
I
R
A
R
A
-
Q
---
I
-----
R
P
E
R
V
D
--------
E
I
E
K
V
T
K
H
D
I
I
A
F
C
T
S
I
A
E
Q
--
F
-
T
----
A
E
T
G---
K
F
F
H
F
G
V
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
A
L
C
D
S
L
L
T
K
A
E
E
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
L
K
D
F
Q
K
D
G
L
T
V
Q
F
S
G
A
V
G
N
Y
C
I
L
T
----
T
------
E
----------
D
E
---
K
K
A
A
D
I
L
G
L
-
P
V
E
-
E
--------
V
S
-
T
Q
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
G
F
------------
K
K
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
R
S
H
V
S
I
A
L
E
-
N
C
-
V
L
W
H
E
R
D
I
S
H
S
S
A
E
R
F
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
T
I
D
N
L
V
V
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
S
S
F
Y
L
H
F
L
V
A
N
T
P
F
M
R
E
D
C
Y
K
I
V
----
Q
Q
---
V
-------
E
S
-------------
F
-
S
K
K
L
Q
K
V
M
H
D
E
H
N
I
I
L
D
I
P
--
E
M
D
F
E
G
I
---
K
K
T
Y
L
----
K
E
I
D
H
V
F
D
R
S
V
K
--------------
46
Fugue
90.00
39%
-86
- C4 -
4EEI
12
?
A:
[1-433]
-----
M
I
K
R
Y
D
V
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
E
D
-
R
--
M
-
V
P
K
G
T
A
A
E
I
R
A
R
A
-
Q
---
I
-----
R
P
E
R
V
D
--------
E
I
E
K
V
T
K
H
D
I
I
A
F
C
T
S
I
A
E
Q
--
F
T
A
----
E
T
G
----
K
F
F
H
F
G
V
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
A
L
C
D
S
L
L
T
K
A
E
E
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
L
K
D
F
Q
K
D
G
L
T
V
Q
F
S
G
A
V
G
N
Y
C
I
L
T
----
T
------
E
----------
D
E
---
K
K
A
A
D
I
L
G
L
-
P
V
E
-
E
--------
V
S
-
T
Q
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
G
F
K
K
------------
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
R
S
H
V
S
I
A
L
E
-
N
C
-
V
L
W
H
E
R
D
I
S
H
S
S
A
E
R
F
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
T
I
D
N
L
V
V
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
S
S
F
Y
L
H
F
L
V
A
N
T
P
F
M
R
E
D
C
Y
K
I
V
----
Q
Q
---
V
E
S
F
S
K
K
L
Q
K
------
V
------
M
-
H
D
E
H
N
I
----
I
L
D
I
--------
P
E
M
D
F
E
G
-
I
K
K
T
Y
L
----
K
E
I
D
H
V
F
D
R
S
V
K
AR------------
30
HHSearch
83.84
23%
-90
- C4 -
3C8T
-
?
A:
[22-453]
------
G
R
S
F
A
D
D
K
M
R
E
L
F
S
A
Q
S
F
I
S
R
C
V
E
T
E
V
A
L
A
R
A
Q
A
R
L
G
--
I
-
I
P
E
D
A
A
A
G
I
T
A
A
A
-
R
---
T
FAP--
E
M
E
R
L
R
--------
D
D
T
E
I
V
G
Y
P
I
L
P
L
V
E
Q
L
S
A
H
--
A
-
G
----
E
A
G
----
K
Y
L
H
W
G
A
T
T
Q
D
I
M
D
T
A
T
V
L
Q
I
R
D
G
L
A
L
I
S
R
R
I
E
S
V
R
K
A
L
A
A
L
A
R
N
H
R
D
T
P
M
A
G
R
T
H
L
Q
H
A
L
P
V
T
F
G
Y
K
A
A
V
W
L
S
A
F
D
R
H
A
A
R
L
E
E
I
S
P
R
V
L
V
V
E
F
S
G
A
S
G
T
L
A
S
L
G
TR
G
-
L
------
D
----------
V
Q
---
R
E
L
A
R
E
L
N
L
-
G
V
--
P
--------
S
I
-
T
W
H
S
A
R
D
A
V
A
E
T
V
Q
F
L
A
L
V
S
G
S
L
G
K
L
A
M
D
I
S
I
M
M
T
T
E
L
G
E
V
A
E
P
---------------
N
P
V
S
C
E
L
I
L
A
G
A
R
I
V
R
N
H
A
T
S
M
L
D
-
A
M
-
I
H
D
F
E
R
A
T
G
P
W
H
L
E
W
S
A
V
P
E
G
F
A
V
A
S
G
I
L
Y
Q
A
E
F
M
L
G
G
L
Q
V
F
P
D
R
M
R
E
N
L
D
H
S
R
G
L
I
V
A
E
A
V
M
M
A
L
A
P
-
H
T
G
R
K
E
A
H
D
I
V
----
Y
L
---
G
C
R
R
A
V
E
D
K
T
------
G
------
L
-
F
E
V
L
R
T
----
M
P
E
V
A
K
P
L
G
--
E
E
A
L
R
D
L
T
-
D
P
R
N
Y
L
----
G
S
A
G
A
M
V
D
N
V
L
G
--------------
50
Fugue
83.47
28%
-95
- C4 -
4NLE
-
?
A:
[18-485]
TIPNV
L
A
N
R
Y
A
S
D
E
M
V
A
I
W
S
P
E
A
K
I
I
A
E
R
R
L
W
L
A
V
L
R
A
Q
A
E
L
G
--
V
A
V
P
D
G
V
V
E
D
Y
E
R
V
L
E
N
---
V
-----
D
L
E
S
I
A
--------
A
R
E
R
-
V
R
H
D
V
K
A
R
I
E
E
F
N
A
H
----------------
E
H
V
H
K
G
M
T
S
R
D
L
T
E
N
V
E
Q
L
Q
I
R
Q
S
L
E
L
V
F
S
H
G
V
A
V
V
A
R
L
A
E
R
A
V
V
Y
R
D
L
V
M
A
G
R
S
H
N
V
A
A
Q
A
T
T
L
G
K
R
F
A
S
A
A
E
E
T
L
V
A
L
T
R
L
R
E
L
I
D
R
Y
P
L
R
G
V
K
G
P
M
G
T
A
Q
D
M
L
----
D
------
L
F
GGD
V
G
K
L
A
D
L
E
---
R
R
V
A
E
F
L
G
F
-
T
E
V
-
F
--------
T
S
V
G
Q
V
Y
P
R
S
L
D
H
D
V
L
S
A
L
V
Q
F
G
A
G
P
S
S
M
A
H
T
I
R
L
M
A
G
H
E
L
--
V
T
E
G
F
A
P
G
Q
V
G
S
S
A
M
P
H
K
M
N
T
R
S
C
E
R
V
N
G
L
Q
V
V
L
R
G
Y
A
S
M
A
A
E
L
A
G
-
A
Q
W
N
E
G
D
V
F
C
S
V
V
R
R
V
A
L
P
D
A
F
F
A
I
D
G
Q
T
E
T
F
L
T
V
L
D
E
F
G
A
Y
P
A
V
I
Q
R
E
L
D
R
Y
L
P
F
L
A
T
T
R
I
L
M
A
A
V
R
A
G
V
G
R
E
A
A
H
E
V
I
----
K
E
---
H
A
V
A
V
A
L
A
M
R
E
QGREP
D
------
L
-
I
D
R
L
A
G
----
D
P
R
L
P
--
L
D
--
K
V
A
L
E
A
A
L
E
D
K
Q
A
F
T
GA
A
G
D
Q
V
D
G
V
V
A
A
V
G
E
L
V
S
R
Y
PEAAKYTSG
26
HHSearch
83.38
24%
-91
- C4 -
1RE5
2
?
A:
[6-443]
-----
F
D
A
Y
F
T
A
P
A
M
R
E
I
F
S
D
R
G
R
L
Q
G
M
L
D
F
E
A
A
L
A
R
A
E
A
S
A
G
--
L
-
V
P
H
S
A
V
A
A
I
E
A
A
C
-
Q
---
A
ERY--
D
T
G
A
L
A
--------
N
A
I
A
T
A
G
N
S
A
I
P
L
V
K
A
L
G
K
V
--
I
-
A
T
GVP
E
A
E
----
R
Y
V
H
L
G
A
T
S
Q
D
A
M
D
T
G
L
V
L
Q
L
R
D
A
L
D
L
I
E
A
D
L
G
K
L
A
D
T
L
S
Q
Q
A
L
K
H
A
D
T
P
L
V
G
R
T
W
L
Q
H
A
T
P
V
T
L
G
M
K
L
A
G
V
L
G
A
L
T
R
H
R
Q
R
L
Q
E
L
R
P
R
L
L
V
L
Q
F
G
G
A
S
G
S
L
A
A
L
G
SK
A
-
M
------
P
----------
V
A
---
E
A
L
A
E
Q
L
K
L
-
T
L
--
P
--------
E
Q
-
P
W
H
T
Q
R
D
R
L
V
E
F
A
S
V
L
G
L
V
A
G
S
L
G
K
F
G
R
D
I
S
L
L
M
Q
T
E
A
G
E
V
F
E
P
S
A
P
----------
K
R
N
P
V
G
A
A
V
L
I
G
A
A
T
R
V
P
G
L
L
S
T
L
F
A
-
A
M
-
P
Q
E
H
E
R
S
L
G
L
W
H
A
E
W
E
T
L
P
D
I
C
C
L
V
S
G
A
L
R
Q
A
Q
V
I
A
E
G
M
E
V
D
A
A
R
M
R
R
N
L
D
L
T
Q
G
L
V
L
A
E
A
V
S
I
V
L
A
-
Q
R
L
G
R
D
R
A
H
H
L
L
----
E
Q
---
C
C
Q
R
A
V
A
E
Q
R
------
H
------
L
-
R
A
V
L
G
D
----
E
P
Q
V
S
A
E
L
S
--
G
E
E
L
D
R
L
L
-
D
P
A
H
Y
L
----
G
Q
A
R
V
W
V
A
R
A
V
S
--------------
27
HHSearch
83.01
25%
-92
- C4 -
1Q5N
-
PCAB_ACIAD
A:
[5-444]
-----
Y
A
S
L
F
Y
Q
R
D
V
T
E
I
F
S
D
R
A
L
V
S
Y
M
V
E
A
E
V
A
L
A
Q
A
Q
A
Q
V
G
--
V
-
I
P
Q
S
A
A
T
V
I
Q
R
A
A
-
K
---
T
AIDKI
D
F
D
A
L
A
--------
T
A
T
G
L
A
G
N
I
A
I
P
F
V
K
Q
L
T
A
I
--
V
-
K
D
A
D
E
D
A
A
----
R
Y
V
H
W
G
A
T
S
Q
D
I
L
D
T
A
C
I
L
Q
C
R
D
A
L
A
I
V
Q
N
Q
V
Q
Q
C
Y
E
T
A
L
S
Q
A
Q
T
Y
R
H
Q
V
M
M
G
R
T
W
L
Q
Q
A
L
P
I
T
L
G
H
K
L
A
R
W
A
S
A
F
K
R
D
L
D
R
I
N
A
I
K
A
R
V
L
V
A
Q
L
G
G
A
V
G
S
L
A
S
L
Q
----
D
Q
G
S
---
I
----------
V
V
---
E
A
Y
A
K
Q
L
K
L
-
G
Q
--
T
--------
A
C
-
T
W
H
G
E
R
D
R
I
V
E
I
A
S
V
L
G
I
I
T
G
N
V
G
K
M
A
R
D
W
S
L
M
M
Q
T
E
I
A
E
V
F
E
P
T
-------------
R
N
P
V
A
A
A
S
V
L
A
A
A
N
R
V
P
A
L
M
S
S
I
Y
Q
-
S
M
-
V
Q
E
H
E
R
S
L
G
A
W
H
A
E
W
L
S
L
P
E
I
F
Q
L
T
A
G
A
L
E
R
T
L
D
V
L
K
G
M
E
V
N
A
E
N
M
H
Q
N
I
E
C
T
H
G
L
I
M
A
E
A
V
M
M
A
L
A
-
P
H
M
G
R
L
N
A
H
H
V
V
----
E
A
---
A
C
K
T
A
V
A
E
Q
K
------
H
------
L
-
K
D
I
I
S
Q
----
V
D
E
V
K
Q
Y
F
N
--
P
S
Q
L
D
E
I
F
-
K
P
E
S
Y
L
----
G
N
I
Q
D
Q
I
D
A
V
L
Q
--------------
9
PsiBlast_PDB
82.54
24%
-97
- C4 -
1RE5
2
?
A:
[10-430]
---------
F
T
A
P
A
M
R
E
I
F
S
D
R
G
R
L
Q
G
M
L
D
F
E
A
A
L
A
R
A
E
A
S
A
G
--
L
-
V
P
H
S
A
V
A
A
I
E
A
A
C
-
Q
AER
Y
-----
D
T
G
A
L
A
--------
N
A
I
A
T
A
G
N
S
A
I
P
L
V
K
A
L
G
K
V
--
I
-
A
----
T
G
V
PEAE
R
Y
V
H
L
G
A
T
S
Q
D
A
M
D
T
G
L
V
L
Q
L
R
D
A
L
D
L
I
E
A
D
L
G
K
L
A
D
T
L
S
Q
Q
A
L
K
H
A
D
T
P
L
V
G
R
T
W
L
Q
H
A
T
P
V
T
L
G
M
K
L
A
G
V
L
G
A
L
T
R
H
R
Q
R
L
Q
E
L
R
P
R
L
L
V
L
Q
F
G
G
A
S
G
S
L
A
A
L
G
----
S
K
A
M
---
P
----------
V
A
---
E
A
L
A
E
Q
L
K
L
T
L
P
E
-----------
Q
-
P
W
H
T
Q
R
D
R
L
V
E
F
A
S
V
L
G
L
V
A
G
S
L
G
K
F
G
R
D
I
S
L
L
M
Q
T
E
A
G
E
V
F
E
P
S
A
P
----------
K
R
N
P
V
G
A
A
V
L
I
G
A
A
T
R
V
P
G
L
L
S
T
L
F
A
-
A
M
-
P
Q
E
H
E
R
S
L
G
L
W
H
A
E
W
E
T
L
P
D
I
C
C
L
V
S
G
A
L
R
Q
A
Q
V
I
A
E
G
M
E
V
D
A
A
R
M
R
R
N
L
D
L
T
Q
G
L
V
L
A
E
A
V
S
I
V
L
A
Q
R
-
L
G
R
D
R
A
H
H
L
L
----
E
Q
---
C
C
Q
R
A
V
A
E
Q
R
------
H
------
L
-
R
A
V
L
G
D
----
E
P
Q
V
S
A
E
L
S
--
G
E
E
L
D
R
L
L
-
D
P
A
H
Y
L
----
G
Q
A
R
V
W
V
A
R
A
V
S
--------------
11
PsiBlast_PDB
82.33
24%
-91
- C4 -
2VD6
8
PUR8_HUMAN
A:
[42-472]
--------
R
Y
A
S
P
E
M
C
F
V
F
S
D
R
Y
K
F
R
T
W
R
Q
L
W
L
W
L
A
E
A
E
Q
T
L
G
LP
I
-
T
D
E
Q
I
Q
E
M
K
S
N
L
E
-
N
---
I
-----
D
F
K
M
A
A
--------
E
E
E
K
R
L
R
H
D
V
M
A
H
V
H
T
F
G
H
C
--
C
-
P
----
K
A
A
----
G
I
I
H
L
G
A
T
S
C
Y
V
G
D
N
T
D
L
I
I
L
R
N
A
L
D
L
L
L
P
K
L
A
R
V
I
S
R
L
A
D
F
A
K
E
R
A
S
L
P
T
L
G
F
T
H
F
Q
P
A
Q
L
T
T
V
G
K
R
C
C
L
W
I
Q
D
L
C
M
D
L
Q
N
L
K
R
V
R
D
D
L
R
F
R
G
V
K
G
T
T
G
T
Q
A
S
F
L
----
Q
------
L
----------
F
E
GD
D
H
K
V
E
Q
L
D
K
M
-
V
T
E
-
K
A
GFKRAFI
I
T
-
G
Q
T
Y
T
R
K
V
D
I
E
V
L
S
V
L
A
S
L
G
A
S
V
H
K
I
C
T
D
I
R
L
L
--
A
N
L
K
E
M
E
E
P
F
E
---------
P
Y
K
R
N
P
M
R
S
E
R
C
C
S
L
A
R
H
L
M
T
L
V
M
D
P
L
Q
-
T
A
S
V
Q
W
F
E
R
T
L
D
D
S
A
N
R
R
I
C
L
A
E
A
F
L
T
A
D
T
I
L
N
T
L
Q
N
I
S
E
G
L
V
V
Y
P
K
V
I
E
R
R
I
R
Q
E
L
P
F
M
A
T
E
N
I
I
M
A
M
V
K
A
G
G
S
R
Q
D
C
H
E
K
I
R
V
L
S
Q
Q
---
A
A
S
V
V
K
Q
E
G
G
------
D
------
N
D
L
I
E
R
I
Q
----
V
D
A
Y
F
S
P
I
H
--
S
Q
-
L
D
H
L
L
-
D
P
S
S
F
T
----
G
R
A
S
Q
Q
V
Q
R
F
L
E
--------------
12
PsiBlast_PDB
81.07
24%
-92
- C4 -
2J91
5
PUR8_HUMAN
A:
[42-472]
--------
R
Y
A
S
P
E
M
C
F
V
F
S
D
R
Y
K
F
R
T
W
R
Q
L
W
L
W
L
A
E
A
E
Q
T
L
G
LP
I
-
T
D
E
Q
I
R
E
M
K
S
N
L
E
-
N
---
I
-----
D
F
K
M
A
A
--------
E
E
E
K
R
L
R
H
D
V
M
A
H
V
H
T
F
G
H
C
--
C
-
P
----
K
A
A
----
G
I
I
H
L
G
A
T
S
C
Y
V
G
D
N
T
D
L
I
I
L
R
N
A
L
D
L
L
L
P
K
L
A
R
V
I
S
R
L
A
D
F
A
K
E
R
A
S
L
P
T
L
G
F
T
H
F
Q
P
A
Q
L
T
T
V
G
K
R
C
C
L
W
I
Q
D
L
C
M
D
L
Q
N
L
K
R
V
R
D
D
L
R
F
R
G
V
K
G
T
T
G
T
Q
A
S
F
L
----
Q
------
L
----------
F
E
GD
D
H
K
V
E
Q
L
D
K
M
-
V
T
E
-
K
A
GFKRAFI
I
T
-
G
Q
T
Y
T
R
K
V
D
I
E
V
L
S
V
L
A
S
L
G
A
S
V
H
K
I
C
T
D
I
R
L
L
--
A
N
L
K
E
M
E
E
P
F
-----------
Y
K
R
N
P
M
R
S
E
R
C
C
S
L
A
R
H
L
M
T
L
V
M
D
P
L
Q
-
T
A
S
V
Q
W
F
E
R
T
L
D
D
S
A
N
R
R
I
C
L
A
E
A
F
L
T
A
D
T
I
L
N
T
L
Q
N
I
S
E
G
L
V
V
Y
P
K
V
I
E
R
R
I
R
Q
E
L
P
F
M
A
T
E
N
I
I
M
A
M
V
--
G
G
S
R
Q
D
C
H
E
K
I
R
V
L
S
Q
Q
---
A
A
S
V
V
K
Q
E
G
G
------
D
------
N
D
L
I
E
R
I
Q
----
V
D
A
Y
F
S
P
I
H
--
S
Q
-
L
D
H
L
L
-
D
P
S
S
F
T
----
G
R
A
S
Q
Q
V
Q
R
F
L
E
--------------
8
PsiBlast_PDB
80.91
25%
-90
- C4 -
1Q5N
-
PCAB_ACIAD
A:
[9-431]
---------
F
Y
Q
R
D
V
T
E
I
F
S
D
R
A
L
V
S
Y
M
V
E
A
E
V
A
L
A
Q
A
Q
A
Q
V
G
--
V
-
I
P
Q
S
A
A
T
V
I
Q
R
A
A
-
K
---
T
-----
A
I
D
K
I
D
F
D
A
L
A
T
A
T
G
L
A
G
N
I
A
I
P
F
V
K
Q
L
T
A
I
V
K
D
--
A
-
D
----
E
D
A
A
---
R
Y
V
H
W
G
A
T
S
Q
D
I
L
D
T
A
C
I
L
Q
C
R
D
A
L
A
I
V
Q
N
Q
V
Q
Q
C
Y
E
T
A
L
S
Q
A
Q
T
Y
R
H
Q
V
M
M
G
R
T
W
L
Q
Q
A
L
P
I
T
L
G
H
K
L
A
R
W
A
S
A
F
K
R
D
L
D
R
I
N
A
I
K
A
R
V
L
V
A
Q
L
G
G
A
V
G
S
L
A
S
L
Q
DQ
G
-
S
------
I
----------
V
V
---
E
A
Y
A
K
Q
L
K
L
--
G
Q
-
T
--------
A
C
-
T
W
H
G
E
R
D
R
I
V
E
I
A
S
V
L
G
I
I
T
G
N
V
G
K
M
A
R
D
W
S
L
M
M
Q
T
E
I
A
E
V
F
E
P
T
-------------
R
N
P
V
A
A
A
S
V
L
A
A
A
N
R
V
P
A
L
M
S
S
I
Y
Q
-
S
M
-
V
Q
E
H
E
R
S
L
G
A
W
H
A
E
W
L
S
L
P
E
I
F
Q
L
T
A
G
A
L
E
R
T
L
D
V
L
K
G
M
E
V
N
A
E
N
M
H
Q
N
I
E
C
T
H
G
L
I
M
A
E
A
V
M
M
A
L
A
P
H
-
M
G
R
L
N
A
H
H
V
V
----
E
A
A
C
K
T
A
V
A
E
Q
K
H
L
K
------
D
------
I
-
I
S
Q
V
D
E
----
V
K
---
Q
Y
F
N
--
P
S
Q
L
D
E
I
F
-
K
P
E
S
Y
L
----
G
N
I
Q
D
Q
I
D
A
V
L
Q
--------------
29
HHSearch
80.57
22%
-95
- C4 -
2J91
5
PUR8_HUMAN
A:
[39-484]
-----
L
A
S
R
Y
A
S
P
E
M
C
F
V
F
S
D
R
Y
K
F
R
T
W
R
Q
L
W
L
W
L
A
E
A
E
Q
T
L
G
--
L
P
I
T
D
E
Q
I
R
E
M
K
S
N
L
-
E
---
N
I----
D
F
K
M
A
A
--------
E
E
E
K
R
L
R
H
D
V
M
A
H
V
H
T
F
G
H
C
--
C
-
P
----
K
A
A
----
G
I
I
H
L
G
A
T
S
C
Y
V
G
D
N
T
D
L
I
I
L
R
N
A
L
D
L
L
L
P
K
L
A
R
V
I
S
R
L
A
D
F
A
K
E
R
A
S
L
P
T
L
G
F
T
H
F
Q
P
A
Q
L
T
T
V
G
K
R
C
C
L
W
I
Q
D
L
C
M
D
L
Q
N
L
K
R
V
R
D
D
L
R
F
R
G
V
K
G
T
T
G
T
Q
A
S
F
L
Q
L
F
E
G
D
D
H
K
V
E
Q
----------
L
D
---
K
M
V
T
E
K
A
G
F
-
K
R
A
F
I
--------
I
T
-
G
Q
T
Y
T
R
K
V
D
I
E
V
L
S
V
L
A
S
L
G
A
S
V
H
K
I
C
T
D
I
R
L
L
A
N
--
L
K
E
M
E
E
P
F
-----------
Y
K
R
N
P
M
R
S
E
R
C
C
S
L
A
R
H
L
M
T
L
V
M
D
P
L
Q
-
T
A
S
V
Q
W
F
E
R
T
L
D
D
S
A
N
R
R
I
C
L
A
E
A
F
L
T
A
D
T
I
L
N
T
L
Q
N
I
S
E
G
L
V
V
Y
P
K
V
I
E
R
R
I
R
Q
E
L
P
F
M
A
T
E
N
I
I
M
A
M
V
--
G
G
S
R
Q
D
C
H
E
K
I
----
R
V
---
L
S
Q
Q
A
A
S
V
V
K
------
Q
EGGDND
L
-
I
E
R
I
Q
V
----
D
----
A
Y
F
S
PI
H
S
Q
L
D
H
L
L
-
D
P
S
S
F
T
----
G
R
A
S
Q
Q
V
Q
R
F
L
E
--------------