@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0137: (2016-03-12 )
MSQIEFKNVSKVYPNGHVGLKNINLNIEKGEFAVIVGLSGAGKSTLLRSVNRLHDITSGEIFIQGKSITKAHGKALLEMRRNIGMIFQHFNLVKRSSVLRNVLSGRVGYHPTWKMVLGLFPKEDKIKAMDALERVNILDKYNQRSDELSGGQQQRISIARALCQESEIILADEPVASLDPLTTKQVMDDLRKINQELGITILINLHFVDLAKEYGTRIIGLRDGEVVYDGPASEATDDVFSEIYGRTIKEDEKLGVN
Atome Classification :
(48 SA)
.........10..-..---.---.---..20........30........40........50........60........70.----------..----------...-..80.-.......90........100.......110......--.120..-.....130.......140.----....-...150.......160.......170.......180.......190.......200.......210.......220.....--------..230..---.....240.......250.....-----------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQ
I
E
FK
N
V
S
KVY-PN---G---H---VG
L
K
N
I
N
L
N
I
EKG
E
F
A
V
I
V
GLSGA
G
K
S
T
L
L
R
S
V
N
R
L
HDITS
G
E
I
F
I
QGKS
I
T
K
A
H
----------
G
K
----------
A
L
L
-
E
M
R
R
N
-
I
G
M
I
F
Q
H
F
N
L
V
K
R
S
S
V
L
R
N
V
L
SGRVGYH
P
T
W
K
M
V
L
G--LFPKE
D
-
K
I
K
A
M
D
A
L
E
R
V
N
I
L
D
K
Y
-N----QRSD-ELSGG
Q
Q
Q
R
I
S
I
A
R
A
L
CQES
E
I
I
L
ADEPVASLDPL
T
T
K
Q
V
M
D
D
L
R
K
I
N
Q
EL
G
I
T
I
L
I
N
L
H
F
V
D
L
A
K
EYG
T
R
I
I
G
LRDG
E
V
V
--------
Y
DGPASE---
A
T
D
D
V
F
S
E
I
YGRTIKEDEKLGVN-----------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.78
40%
-97
- C1 -
4U02
1
?
A:
[5-224]
---
I
R
I
R
N
L
H
K
W
F
-
G
P
---
L
---
H
---
V
-
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
------------
D
R
----------
A
L
R
-
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
--------
P
M
R
V
R
--
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
----
K
Y
P
A
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
--------
E
E
G
R
P
E
E
-------------------------------------------------------------------------------------------------------------------
122
Fugue
90.71
33%
-95
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
-
H
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
TRT
I
---
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
----------
E
S
----------
E
L
T
-
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
--------
N
--
T
P
K
D
E
V
-
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
----
S
Y
P
S
-
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
S
E
---
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
EDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV
21
PsiBlast_CBE
90.58
40%
-101
- C1 -
4U02
1
?
D:
[5-224]
---
I
R
I
R
N
L
H
K
W
F
-
G
P
---
L
---
H
---
V
-
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
------------
D
R
----------
A
L
R
-
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
--------
P
M
R
V
R
--
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
----
K
Y
P
A
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
--------
E
E
G
R
P
E
E
-------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
89.68
40%
-103
- C1 -
4U02
1
?
B:
[5-224]
---
I
R
I
R
N
L
H
K
W
F
-
G
P
---
L
---
H
---
V
-
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
------------
D
R
----------
A
L
R
-
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
--------
P
M
R
V
R
--
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
----
K
Y
P
A
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
--------
E
E
G
R
P
E
E
-------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.28
40%
-102
- C1 -
4U00
3
?
A:
[5-224]
---
I
R
I
R
N
L
H
K
W
F
-
G
P
---
L
---
H
---
V
-
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
------------
D
R
----------
A
L
R
-
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
--------
P
M
R
V
R
--
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
----
K
Y
P
A
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
--------
E
E
G
R
P
E
E
-------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
86.29
40%
-105
- C1 -
4U02
1
?
C:
[5-224]
---
I
R
I
R
N
L
H
K
W
F
-
G
P
---
L
---
H
---
V
-
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
------------
D
R
----------
A
L
R
-
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
--------
P
M
R
V
R
--
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
----
K
Y
P
A
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
--------
E
E
G
R
P
E
E
-------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
84.58
39%
-99
- C1 -
1F3O
2
Y796_METJA
A:
[2-223]
---
I
K
L
K
N
V
T
K
T
Y
-
K
M
---
G
---
E
EII
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
----------
D
D
----------
E
L
T
-
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
I
-----
F
K
Y
R
G
A
--
M
S
G
E
E
R
-
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
----
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
83.37
36%
-98
* C1 *
3TUI
1
METN_ECOLI
C:
[23-253]
-
H
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
GTR
T
---
I
---
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
----------
E
S
----------
E
L
T
-
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
--------
N
--
T
P
K
D
E
V
-
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
----
S
Y
P
S
-
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
S
E
---
V
F
S
-------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
83.29
35%
-106
- C1 -
3TUI
1
METN_ECOLI
G:
[25-253]
---
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
----------
E
S
----------
E
L
T
-
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
---------
A
L
P
L
E
L
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
----
S
Y
P
S
-
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
S
E
-------
V
F
S
---------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
83.14
39%
-105
- C1 -
1L2T
4
Y796_METJA
B:
[2-223]
---
I
K
L
K
N
V
T
K
T
Y
-
K
M
---
G
---
E
EII
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
----------
D
D
----------
E
L
T
-
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
I
-----
F
K
Y
R
G
A
--
M
S
G
E
E
R
-
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
----
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
82.74
35%
-107
- C1 -
3TUI
1
METN_ECOLI
C:
[25-253]
---
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
----------
E
S
----------
E
L
T
-
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
---------
A
L
P
L
E
L
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
----
S
Y
P
S
-
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
S
E
-------
V
F
S
---------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
82.53
40%
-109
- C1 -
4YMU
2
?
A:
[17-222]
-----------------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
--
N
----------
G
K
----------
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
---------
K
E
A
-
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
----
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
--------
E
E
G
T
P
E
E
-------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
82.26
38%
-109
- C1 -
3TIF
7
Y796_METJA
B:
[2-223]
---
V
K
L
K
N
V
T
K
T
Y
-
K
M
---
G
---
E
EII
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
----------
D
D
----------
E
L
T
-
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
I
-----
F
K
Y
R
G
A
--
M
S
G
E
E
R
-
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
----
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
82.22
35%
-108
- C1 -
3TUZ
1
METN_ECOLI
H:
[25-253]
---
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
----------
E
S
----------
E
L
T
-
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
---------
A
L
P
L
E
L
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
----
S
Y
P
S
-
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
S
E
-------
V
F
S
---------------------------------------------------------------------------------------------------------
118
HHSearch
82.14
33%
-103
- C1 -
1B0U
4
HISP_SALTY
A:
[5-245]
-
N
K
L
H
V
I
D
L
H
K
R
Y
-
G
----
G
---
H
---
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQLKVAD
K
N
----------
Q
L
R
-
L
L
R
T
R
-
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
-------
L
G
--
L
S
K
H
D
A
-
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
----
K
Y
P
V
-
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
--------
E
E
G
D
P
E
Q
---
V
F
G
N
P
Q
----------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
81.91
35%
-113
- C1 -
3TUZ
1
METN_ECOLI
C:
[25-253]
---
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
----------
E
S
----------
E
L
T
-
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
---------
A
L
P
L
E
L
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
----
S
Y
P
S
-
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
S
E
-------
V
F
S
---------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
81.74
39%
-101
- C1 -
1L2T
4
Y796_METJA
A:
[2-223]
---
I
K
L
K
N
V
T
K
T
Y
-
K
M
---
G
---
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
----------
D
D
----------
E
L
T
-
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
I
-----
F
K
Y
R
G
A
--
M
S
G
E
E
R
-
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
----
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.97
36%
-103
- C1 -
3DHW
-
METN_ECOLI
C:
[2-230]
---
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
----------
E
S
----------
E
L
T
-
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
---------
A
L
P
L
E
L
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
----
S
Y
P
S
-
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
S
E
-------
V
F
S
---------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
80.94
35%
-108
- C1 -
3TUI
1
METN_ECOLI
H:
[25-253]
---
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
----------
E
S
----------
E
L
T
-
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
---------
A
L
P
L
E
L
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
----
S
Y
P
S
-
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
S
E
-------
V
F
S
---------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
80.53
35%
-106
- C1 -
3TUZ
1
METN_ECOLI
G:
[25-253]
---
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
----------
E
S
----------
E
L
T
-
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
---------
A
L
P
L
E
L
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
-
D
----
S
Y
P
S
-
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
S
E
-------
V
F
S
---------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.48
40%
-104
- C1 -
4YMV
1
?
J:
[17-222]
-----------------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
--
N
----------
G
K
----------
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
---------
K
E
A
-
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
----
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
--------
E
E
G
T
P
E
E
-------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
79.97
40%
-106
- C1 -
4YMV
1
?
A:
[17-222]
-----------------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
--
N
----------
G
K
----------
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
---------
K
E
A
-
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
----
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
--------
E
E
G
T
P
E
E
-------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
79.67
36%
-106
- C1 -
2OLK
1
?
C:
[40-263]
-----------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
----------
D
T
----------
N
L
N
-
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
--------
P
M
K
V
R
--
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
----
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
EEGKPEDL
F
D
R
P
Q
H
E
---
R
T
K
A
F
L
S
K
V
F
------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
79.23
38%
-100
- C1 -
3TIF
7
Y796_METJA
A:
[2-223]
---
V
K
L
K
N
V
T
K
T
Y
-
K
M
---
G
---
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
----------
D
D
----------
E
L
T
-
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
I
-----
F
K
Y
R
G
A
--
M
S
G
E
E
R
-
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
----
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.05
40%
-107
- C1 -
4YMU
2
?
J:
[17-222]
-----------------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
--
N
----------
G
K
----------
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
---------
K
E
A
-
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
----
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
--------
E
E
G
T
P
E
E
-------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
78.99
36%
-106
- C1 -
2OLK
1
?
A:
[40-263]
-----------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
----------
D
T
----------
N
L
N
-
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
--------
P
M
K
V
R
--
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
----
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
EEGK
P
E
D
L
F
D
R
P
Q
H
E
---
R
T
K
A
F
L
S
K
V
F
------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
78.44
36%
-105
- C1 -
3C4J
4
?
B:
[40-263]
-----------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
----------
D
T
----------
N
L
N
-
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
--------
P
M
K
V
R
--
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
----
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
EEGKPEDL
F
D
R
P
Q
H
E
---
R
T
K
A
F
L
S
K
V
F
------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
76.27
31%
-89
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[8-242]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
---
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----------
P
N
----------
W
L
----
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
N
P
G
M
S
-----
V
E
K
--
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
Y
-
N
TIVG
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
--------
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
76.16
36%
-108
- C1 -
2OLJ
4
?
A:
[40-263]
-----------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
----------
D
T
----------
N
L
N
-
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
--------
P
M
K
V
R
--
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
----
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
EEGK
P
E
D
L
F
D
R
P
Q
H
E
---
R
T
K
A
F
L
S
K
V
F
------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
74.47
33%
-109
- C1 -
1B0U
4
HISP_SALTY
A:
[18-235]
-------------------
G
---
H
---
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
----------
D
K
DGQLKVAD
K
N
Q
L
R
-
L
L
R
T
R
-
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
-------
Q
V
L
G
--
L
S
K
H
D
A
-
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
-
Q
----
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
--------
E
E
G
-----------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
74.16
36%
-102
- C1 -
2OLK
2
?
B:
[40-263]
-----------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
----------
D
T
----------
N
L
N
-
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
--------
P
M
K
V
R
--
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
----
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
EEGKPEDL
F
D
R
P
Q
H
E
---
R
T
K
A
F
L
S
K
V
F
------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
73.89
36%
-101
- C1 -
2OLJ
3
?
B:
[40-263]
-----------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
----------
D
T
----------
N
L
N
-
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
--------
P
M
K
V
R
--
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
----
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
EEGKPEDL
F
D
R
P
Q
H
E
---
R
T
K
A
F
L
S
K
V
F
------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
73.78
36%
-102
- C1 -
3C41
3
?
J:
[19-242]
-----------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
----------
D
T
----------
N
L
N
-
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
--------
P
M
K
V
R
--
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
----
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
EEGKPEDL
F
D
R
P
Q
H
E
---
R
T
K
A
F
L
S
K
V
F
------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
73.72
31%
-92
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[8-242]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
---
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----------
P
N
----------
W
L
----
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
N
P
G
M
S
-----
V
E
K
--
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
Y
-
N
TIVG
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
--------
E
Q
G
K
H
K
E
LLS
E
P
E
S
L
Y
S
Y
L
Y
------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
73.67
36%
-104
- C1 -
2OLK
1
?
D:
[40-263]
-----------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
----------
D
T
----------
N
L
N
-
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
--------
P
M
K
V
R
--
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
----
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
EEGKPEDL
F
D
R
P
Q
H
E
---
R
T
K
A
F
L
S
K
V
F
------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
73.50
31%
-87
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[8-242]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
---
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----------
P
N
----------
W
L
----
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
N
P
G
M
S
-----
V
E
K
--
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
Y
-
N
T
I
V
G
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
--------
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.43
36%
-102
- C1 -
2Q0H
4
?
A:
[40-263]
-----------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
----------
D
T
----------
N
L
N
-
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
--------
P
M
K
V
R
--
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
----
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
EEGK
P
E
D
L
F
D
R
P
Q
H
E
---
R
T
K
A
F
L
S
K
V
F
------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
73.40
31%
-90
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[8-242]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
---
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----------
P
N
----------
W
L
----
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
N
P
G
M
S
-----
V
E
K
--
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
Y
-
N
TIVG
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
--------
E
Q
G
K
H
K
E
LLS
E
P
E
S
L
Y
S
Y
L
Y
------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
72.90
36%
-100
- C1 -
3C4J
3
?
A:
[40-263]
-----------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
----------
D
T
----------
N
L
N
-
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
--------
P
M
K
V
R
--
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
----
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
EEGK
P
E
D
L
F
D
R
P
Q
H
E
---
R
T
K
A
F
L
S
K
V
F
------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
72.62
31%
-94
- C1 -
1XEF
3
D:
[2-236]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
---
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----------
P
N
----------
W
L
----
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
N
P
G
M
S
-----
V
E
K
--
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
Y
-
N
TIVG
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
--------
E
Q
G
K
H
K
E
LLS
E
P
E
S
L
Y
S
Y
L
Y
------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
72.43
31%
-95
- C1 -
2FGJ
2
D:
[8-242]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
---
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----------
P
N
----------
W
L
----
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
N
P
G
M
S
-----
V
E
K
--
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
Y
-
N
TIVG
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
--------
E
Q
G
K
H
K
E
LLS
E
P
E
S
L
Y
S
Y
L
Y
------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
72.40
31%
-93
- C1 -
2FGK
2
D:
[8-242]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
---
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----------
P
N
----------
W
L
----
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
N
P
G
M
S
-----
V
E
K
--
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
Y
-
N
TIVG
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
--------
E
Q
G
K
H
K
E
LLS
E
P
E
S
L
Y
S
Y
L
Y
------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
72.30
32%
-92
- C1 -
2PMK
1
A:
[4-238]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
---
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----------
P
N
----------
W
L
----
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
N
P
G
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
-
F
I
S
E
L
R
--
E
G
Y
N
T
I
--
V
-
G
----
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
--------
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
71.36
36%
-104
- C1 -
3C41
3
?
K:
[19-242]
-----------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
----------
D
T
----------
N
L
N
-
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
--------
P
M
K
V
R
--
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
----
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
EEGKPEDL
F
D
R
P
Q
H
E
---
R
T
K
A
F
L
S
K
V
F
------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
71.14
31%
-81
- C1 -
2FFA
2
A:
[8-242]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
---
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----------
P
N
----------
W
L
----
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
N
P
G
M
S
-----
V
E
K
--
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
Y
-
N
TIVG
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
--------
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
70.48
36%
-102
- C1 -
2Q0H
4
?
B:
[40-263]
-----------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
----------
D
T
----------
N
L
N
-
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
--------
P
M
K
V
R
--
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
----
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
EEGK
P
E
D
L
F
D
R
P
Q
H
E
---
R
T
K
A
F
L
S
K
V
F
------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
70.07
31%
-84
- C1 -
2FF7
1
A:
[8-242]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
---
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----------
P
N
----------
W
L
----
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
N
P
G
M
S
-----
V
E
K
--
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
Y
-
N
TIVG
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
--------
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
68.93
31%
-92
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[8-242]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
---
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----------
P
N
----------
W
L
----
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
S
L
A
N
P
G
M
S
-----
V
E
K
--
V
I
Y
A
A
K
-
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
Y
-
N
TIVG
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
--------
E
Q
G
K
H
K
E
LLS
E
P
E
S
L
Y
S
Y
L
Y
------------------------------------------------------------------------------------------------------