@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1142: (2016-03-22 )
MALSTFKREHIKKNLRNDEYDLVIIGGGITGAGIALDASERGMKVALVEMQDFAQGTSSRSTKLVHGGLRYLKQFQIGVVAETGKERAIVYENGPHVTTPEWMLLPMHKGGTFGKFSTSIGLGMYDRLAGVKKSERKKMLSKKETLAKEPLVKKEGLKGGGYYVEYRTDDARLTIEVMKRAAEKGAEIINYTKSEHFTYDKNQQVNGVKVIDKLTNENYTIKAKKVVNAAGPWVDDVRSGDYARNNKKLRLTKGVHVVIDQSKFPLGQAVYFDTEKDGRMIFAIPREGKAYVGTTDTFYDNIKSSPLTTQEDRDYLIDAINYMFPSVNVTDEDIESTWAGIRPLIYEEGKDPSEISRKDEIWEGKSGLLTIAGGKLTGYRHMAQDIVDLVSKRLKKDYGLTFSPCNTKGLAISGGDVGGSKNFDAFVEQKVDVAKGFGIDEDVARRLASKYGSNVDELFNIAQTSQYHDSKLPLEIYVELVYSIQQEMVYKPNDFLVRRSGKMYFNIKDVLDYKDAVIDIMADMLDYSPAQIEAYTEEVEQAIKEAQHGNNQPAVKE
Atome Classification :
(20 SA)
.........10........20........30........40...-.....50-..--..--....60........70..-......80........90....-----..-..100...---------------....---110----.......120.....-..130.-.....-.140.......150...---....160...-.-..----.170.......180...-....190.......200.......210--........220.......230------------...----..-.----.---.240-..--.-....250..-------.....-260.-..---------....270....---.-...280.---....-...-290.......300----------------.....--....310.......320.......330...-....--340...-----------..------..350.....------..360.......370.-...---.---....380.......390.......400.......410.......420....--....430...---....440--........450.......460.......--470-......-..480.......490.......500-.......510.......520.......530.......540.......550.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
L
S
T
F
K
R
E
H
I
K
K
NLRNDEY
D
L
V
I
IGGGITGA
G
I
A
LDASERG
M
K
-
V
A
L
V
E
M
Q
-
D
F
--AQ--GTSSRS
T
K
L
V
H
G
G
L
R
Y
L
K
-
Q
FQ
I
G
V
V
A
ETGK
E
R
A
I
V
YENGP-----HV-TTP
E
W
M
L
L
---------------
P
M
HK---GGT----FGKFSTSIG
L
G
M
Y
D
R
-
L
AGV
K
K
-
S
E
R
K
K
-
M
L
S
K
K
E
T
LAKEPL
V
K
KE---GLKGG
G
Y
Y
V
E
-
Y
-RT----DD
A
R
L
T
I
E
V
M
K
R
A
A
EKG-A
E
I
I
N
YTKSEHFTYDKNQQVN
G
V
K
V
I
---
D
K
LTNE
N
Y
T
I
K
A
K
K
V
VNAAG-------------P
W
V
----
D
D-V----R---SGDY-AR--N-N
K
K
L
R
L
TK
G
-------
V
H
V
V
I
-DQSK-FP---------LG
Q
A
V
-
Y
F
DTE---K-D
G
R
M
I
-
F
---
A
IPR-EG
K
-
A
Y
VGT
T
D
T
F
Y
D
------------------NIKSS--PLTTQE
D
R
D
Y
L
I
D
A
I
N
Y
MFPSVNV
T
D
E
D
I
E
-
S
T
W
A--GIR
P
L
I-----------YE------EGK
D
P
S
E
ISR------
K
D
EIWEGKS
G
L
L
T
--I-AGG---K---LT
G
Y
R
H
M
A
Q
D
I
V
D
L
V
S
K
R
L
K
K
DYG
L
T
FSPCNTK
G
L
A
I
SGGDVGGSK-
N
F
D
A
--
F
V
E
Q
K
V
D
V
AK---GFGI
D
E
---
D
V
A
R
R
L
A
S
KYGS
N
V
D
E
L
F
N
I
A
Q
TSQYHD--SK--L
P
L
E
I
Y
-
V
E
L
V
Y
S
I
Q
Q
E
MVYKPN
D
F
L
V
RRS
G
K
-
M
Y
F
N
I
K
D
VLDY
K
D
A
V
I
D
I
M
A
D
M
LDYS
P
A
Q
I
E
A
Y
T
E
E
V
E
Q
A
I
K
E
A
QHGNNQPAVKE
92
HHSearch
90.97
57%
-59
- C4 -
3DA1
1
?
A:
[3-543]
---
S
A
K
K
R
D
K
C
I
G
E
M
S
E
K
Q
L
D
L
L
V
I
G
G
G
I
T
G
A
G
I
A
L
D
A
Q
V
R
G
I
Q
-
T
G
L
V
E
M
N
-
D
F
--
A
S
--
G
T
S
S
R
S
T
K
L
V
H
G
----------------
V
G
K
E
R
A
I
V
Y
E
N
A
P
-----
H
V
-
T
T
P
E
W
M
L
L
---------------
P
I
F
K
------------------------------------
R
Y
-
M
L
N
E
K
Q
T
L
E
K
E
P
L
L
R
K
E
---
N
L
K
G
G
G
I
Y
V
E
-
Y
-
R
T
----
D
D
A
R
L
T
L
E
I
M
K
E
A
V
A
R
G
-
A
V
A
L
N
Y
M
K
V
E
S
F
I
Y
D
-
Q
G
K
V
V
G
V
V
A
K
---
D
R
L
T
D
T
T
H
T
I
Y
A
K
K
V
V
N
A
A
G
-------------
P
W
V
----
D
T
-
L
----
R
---
E
K
D
R
-
S
K
--
H
-
G
K
Y
L
K
L
S
K
G
-------
V
H
L
V
V
-
D
Q
S
R
-
F
P
---------
L
R
Q
A
--
V
Y
F
D
T
E--
S
-
D
G
R
M
I
-
F
---
A
I
P
R
-
E
G
K
-
T
Y
I
G
T
T
D
T
F
Y
D
------------------
K
D
I
A
S
--
P
R
M
T
V
E
D
R
D
Y
I
L
A
A
A
N
Y
M
F
P
S
L
R
L
T
A
D
D
V
E
-
S
S
W
A
--
G
L
R
P
L
I
-----------
H
E
-----------------------
D
E
I
F
F
S
D
S
G
L
I
S
--
I
-
A
G
G
---
K
---
L
T
G
Y
R
K
M
A
E
R
T
V
D
A
V
A
Q
G
L
----
N
V
N
-
E
P
C
T
T
A
A
I
R
L
S
G
G
L
A
E
G
A
Q
-
G
F
P
R
--
F
L
D
E
A
S
R
K
G
A
---
K
L
G
F
D
A
---
D
E
V
R
R
L
A
K
L
Y
G
S
N
V
D
H
V
L
N
Y
A
Y
E
G
K
E
E
A
E
H
Y
G
--
L
P
A
L
L
L
-
G
Q
L
Q
Y
G
V
E
Q
E
M
V
A
T
P
L
D
F
F
V
R
R
T
G
A
-
L
F
F
N
I
S
L
V
H
Q
W
K
E
A
V
L
R
W
M
A
E
E
F
S
W
T
E
E
E
K
T
R
F
Q
N
E
L
E
T
E
L
K
M
A
V
D
---------
1
PsiBlast_PDB
90.70
55%
-61
- C4 -
3DA1
1
?
A:
[2-541]
--
F
S
A
K
K
R
D
K
C
I
G
E
M
S
E
K
Q
L
D
L
L
V
I
G
G
G
I
T
G
A
G
I
A
L
D
A
Q
V
R
G
I
Q
-
T
G
L
V
E
M
N
-
D
F
--
A
S
--
G
T
S
S
R
S
T
K
L
V
H
G
----------------
V
G
K
E
R
A
I
V
Y
E
N
A
P
-----
H
V
-
T
T
P
E
W
M
L
L
---------------
P
I
F
K
------------------------------------
R
Y
-
M
L
N
E
K
Q
T
L
E
K
E
P
L
L
R
K
E
---
N
L
K
G
G
G
I
Y
V
E
-
Y
-
R
T
----
D
D
A
R
L
T
L
E
I
M
K
E
A
V
A
R
G
-
A
V
A
L
N
Y
M
K
V
E
S
F
I
Y
D
Q
G
K
V
V
-
G
V
V
A
K
---
D
R
L
T
D
T
T
H
T
I
Y
A
K
K
V
V
N
A
A
G
-------------
P
W
V
----
D
T
-
L
----
R
---
E
K
D
R
-
S
K
--
H
-
G
K
Y
L
K
L
S
K
G
-------
V
H
L
V
V
-
D
Q
S
R
-
F
P
---------
L
R
Q
A
V
-
Y
F
D
T
E
---
S
-
D
G
R
M
I
-
F
---
A
I
P
R
-
E
G
K
-
T
Y
I
G
T
T
D
T
F
Y
D
------------------
K
D
I
A
S
--
P
R
M
T
V
E
D
R
D
Y
I
L
A
A
A
N
Y
M
F
P
S
L
R
L
T
A
D
D
V
E
-
S
S
W
A
--
G
L
R
P
L
I
-----------
H
E
-----------------------
D
E
I
F
F
S
D
S
G
L
I
S
--
I
-
A
G
G
---
K
---
L
T
G
Y
R
K
M
A
E
R
T
V
D
A
V
A
Q
G
L
N
V
N
-----
E
P
C
T
T
A
A
I
R
L
S
G
G
L
A
E
G
A
Q
-
G
F
P
R
--
F
L
D
E
A
S
R
K
G
A
---
K
L
G
F
D
A
---
D
E
V
R
R
L
A
K
L
Y
G
S
N
V
D
H
V
L
N
Y
A
Y
E
G
K
E
E
A
--
E
H
Y
G
L
P
A
L
L
L
-
G
Q
L
Q
Y
G
V
E
Q
E
M
V
A
T
P
L
D
F
F
V
R
R
T
G
A
-
L
F
F
N
I
S
L
V
H
Q
W
K
E
A
V
L
R
W
M
A
E
E
F
S
W
T
E
E
E
K
T
R
F
Q
N
E
L
E
T
E
L
K
M
A
-----------
93
HHSearch
88.08
42%
-51
- C4 -
2RGH
2
?
A:
[17-569]
---
S
N
K
T
R
Q
D
S
I
Q
K
M
Q
Q
E
E
L
D
L
L
I
I
G
G
G
I
T
G
A
G
V
A
V
Q
A
A
A
S
G
I
K
-
T
G
L
I
E
M
Q
-
D
F
--
A
E
--
G
T
S
S
R
S
T
K
L
V
H
G
G
I
R
Y
L
K
-
T
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
A
P
-----
H
I
-
P
K
P
D
P
M
L
L
---------------
P
I
Y
E
---
D
E
G
ATT-
F
N
M
F
S
V
K
V
A
M
D
L
Y
D
K
-
L
A
N
V
T
G
T
K
Y
E
N
Y
-
T
L
T
P
E
E
V
L
E
R
E
P
F
L
K
K
E
---
G
L
K
G
A
G
V
Y
L
D
-
F
-
R
N
----
N
D
A
R
L
V
I
D
N
I
K
K
A
A
E
D
G
-
A
Y
L
V
S
K
M
K
A
V
G
F
L
Y
E
-
G
D
Q
I
V
G
V
K
A
R
---
D
L
L
T
D
E
V
I
E
I
K
A
K
L
V
I
N
T
S
G
-------------
P
W
V
----
D
K
-
V
----
R
---
N
L
N
F
T
R
P
--
V
-
S
P
K
M
R
P
T
K
G
-------
I
H
L
V
V
-
D
A
K
K
-
L
P
---------
V
P
Q
P
--
T
Y
F
D
T
GK-
Q
-
D
G
R
M
V
-
F
---
A
I
P
R
-
E
N
K
-
T
Y
F
G
T
T
D
T
D
Y
Q
------------------
G
D
F
T
D
--
P
K
V
T
Q
E
D
V
D
Y
L
L
D
V
I
N
H
R
Y
P
E
A
N
I
T
L
A
D
I
E
-
A
S
W
A
--
G
L
R
P
L
L
-----------
I
G
-----------------------
S
S
L
E
R
E
P
D
G
L
L
T
--
L
-
S
G
G
---
K
---
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
R
Q
L
L
K
E
E
Y
G
I
E
T
K
E
I
D
S
K
K
Y
Q
I
S
G
G
N
F
D
P
T
K
--
L
E
E
--
T
V
T
E
L
A
K
E
G
V
---
A
A
G
L
E
E
---
E
D
A
T
Y
I
A
D
F
Y
G
T
N
A
R
R
I
F
E
L
A
K
E
M
A
P
-
Y
--
P
G
--
L
S
L
A
E
S
-
A
R
L
R
Y
G
L
E
E
E
M
V
L
A
P
G
D
Y
L
I
R
R
T
N
H
-
L
L
F
E
R
D
Q
L
D
E
I
K
Q
P
V
I
D
A
I
A
E
Y
F
G
W
T
E
E
E
K
A
Q
Q
T
K
R
L
E
A
L
I
A
E
S
D
L
R
E
L
K
G
----
3
PsiBlast_PDB
87.78
40%
-64
- C4 -
2RGO
1
?
A:
[2-598]
--
F
S
N
K
T
R
Q
D
S
I
Q
K
M
Q
Q
E
E
L
D
L
L
I
I
G
G
G
I
T
G
A
G
V
A
V
Q
A
A
A
S
G
I
K
-
T
G
L
I
E
M
Q
-
D
F
--
A
E
--
G
T
S
S
R
S
T
K
L
V
H
G
G
I
R
Y
L
K
-
T
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
A
P
-----
H
I
-
P
K
P
D
P
M
L
L
---------------
P
I
Y
E
DEG
A
T
T
----
F
N
M
F
S
V
K
V
A
M
D
L
Y
D
K
-
L
A
N
V
T
G
-
T
K
Y
E
N
Y
T
L
T
P
E
E
V
L
E
R
E
P
F
L
K
K
E
---
G
L
K
G
A
G
V
Y
L
D
-
F
-
R
N
----
N
D
A
R
L
V
I
D
N
I
K
K
A
A
E
D
G
-
A
Y
L
V
S
K
M
K
A
V
G
F
L
Y
E
G
D
Q
I
V
-
G
V
K
A
R
---
D
L
L
T
D
E
V
I
E
I
K
A
K
L
V
I
N
T
S
G
-------------
P
W
V
----
D
K
-
V
----
R
---
N
L
N
F
-
T
R
--
P
V
S
P
K
M
R
P
T
K
G
-------
I
H
L
V
V
-
D
A
K
K
-
L
P
---------
V
P
Q
P
T
-
Y
F
D
T
G
---
K
Q
D
G
R
M
V
-
F
---
A
I
P
R
-
E
N
K
-
T
Y
F
G
T
T
D
T
D
Y
Q
------------------
G
D
F
T
D
--
P
K
V
T
Q
E
D
V
D
Y
L
L
D
V
I
N
H
R
Y
P
E
A
N
I
T
L
A
D
I
E
-
A
S
W
A
--
G
L
R
P
L
L
IGNSGSDYNGG--------------
T
I
S
R
------
G
S
S
L
E
R
E
P
D
G
L
L
T
--
L
-
S
G
G
---
K
---
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
R
Q
L
L
K
E
E
Y
G
I
E
T
K
E
I
D
S
K
K
Y
Q
I
S
G
G
-------
N
F
D
P
TK
L
E
E
T
V
T
E
L
A
K
E
G
V
A
A
G
L
E
E
---
E
D
A
T
Y
I
A
D
F
Y
G
T
N
A
R
R
I
F
E
L
A
K
E
-
A
P
Y
P
--
G
---
L
S
L
A
E
S
-
A
R
L
R
Y
G
L
E
E
E
M
V
L
A
P
G
D
Y
L
I
R
R
T
N
H
-
L
L
F
E
R
D
Q
L
D
E
I
K
Q
P
V
I
D
A
I
A
E
Y
F
G
W
T
E
E
E
K
A
Q
Q
T
K
R
L
E
A
L
I
A
E
S
-----------
21
PsiBlast_CBE
84.79
40%
-63
- C4 -
2RGO
1
?
B:
[2-598]
--
F
S
N
K
T
R
Q
D
S
I
Q
K
M
Q
--
E
L
D
L
L
I
I
G
G
G
I
T
G
A
G
V
A
V
Q
A
A
A
S
G
I
K
-
T
G
L
I
E
M
Q
-
D
F
--
A
E
--
G
T
S
S
R
S
T
K
L
V
H
G
G
I
R
Y
L
K
-
T
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
A
P
-----
H
I
-
P
K
P
D
P
M
L
L
---------------
P
I
Y
E
DE--
T
T
----
F
N
M
F
S
V
K
V
A
M
D
L
Y
D
K
-
L
A
N
V
T
G
-
T
K
Y
E
N
Y
T
L
T
P
E
E
V
L
E
R
E
P
F
L
K
K
E
---
G
L
K
G
A
G
V
Y
L
D
-
F
-
R
N
----
N
D
A
R
L
V
I
D
N
I
K
K
A
A
E
D
G
-
A
Y
L
V
S
K
M
K
A
V
G
F
L
Y
-
G
D
Q
I
V
-
G
V
K
A
R
---
D
L
L
T
D
E
V
I
E
I
K
A
K
L
V
I
N
T
S
G
-------------
P
W
V
----
D
K
-
V
----
R
---
N
L
N
F
-----
P
V
S
P
K
M
R
P
T
K
G
-------
I
H
L
V
V
-
D
A
K
K
-
L
P
---------
V
P
Q
P
T
-
Y
F
D
T
G
---
K
Q
D
G
R
M
V
-
F
---
A
I
P
R
-
E
N
K
-
T
Y
F
G
T
T
D
T
D
Y
Q
------------------
G
D
F
T
D
--
P
K
V
T
Q
E
D
V
D
Y
L
L
D
V
I
N
H
R
Y
P
E
A
N
I
T
L
A
D
I
E
-
A
S
W
A
--
G
L
R
P
L
L
IGNSGSDYNGG---------------
I
S
R
------
G
S
S
L
E
R
E
P
D
G
L
L
T
--
L
-
S
G
G
---
K
---
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
R
Q
L
L
K
E
E
Y
G
I
E
T
K
E
I
D
S
K
K
Y
Q
I
S
G
G
-------
N
F
D
P
TK----------------------
E
D
A
T
Y
I
A
D
F
Y
G
T
N
A
R
R
I
F
E
L
A
---
A
P
Y
P
--
G
---
L
S
L
A
E
S
-
A
R
L
R
Y
G
L
E
E
E
M
V
L
A
P
G
D
Y
L
I
R
R
T
N
H
-
L
L
F
E
R
D
Q
L
D
E
I
K
Q
P
V
I
D
A
I
A
E
Y
F
G
W
T
E
E
E
K
A
Q
Q
T
K
R
L
E
A
L
I
A
E
S
-----------
2
PsiBlast_PDB
80.62
42%
-50
- C4 -
2RGH
2
?
A:
[55-562]
-----------------------------------------
G
I
K
-
T
G
L
I
E
M
Q
-
D
F
--
A
E
--
G
T
S
S
R
S
T
K
L
V
H
G
G
I
R
Y
L
K
-
T
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
A
P
-----
H
I
-
P
K
P
D
P
M
L
L
---------------
P
I
Y
E
DEG
A
T
T
----
F
N
M
F
S
V
K
V
A
M
D
L
Y
D
K
-
L
A
N
V
T
G
-
T
K
Y
E
N
Y
T
L
T
P
E
E
V
L
E
R
E
P
F
L
K
K
E
---
G
L
K
G
A
G
V
Y
L
D
-
F
-
R
N
----
N
D
A
R
L
V
I
D
N
I
K
K
A
A
E
D
G
-
A
Y
L
V
S
K
M
K
A
V
G
F
L
Y
E
G
D
Q
I
V
-
G
V
K
A
R
---
D
L
L
T
D
E
V
I
E
I
K
A
K
L
V
I
N
T
S
G
-------------
P
W
V
----
D
K
-
V
----
R
---
N
L
N
F
-
T
R
--
P
V
S
P
K
M
R
P
T
K
G
-------
I
H
L
V
V
-
D
A
K
K
-
L
P
---------
V
P
Q
P
T
-
Y
F
D
T
G
---
K
Q
D
G
R
M
V
-
F
---
A
I
P
R
-
E
N
K
-
T
Y
F
G
T
T
D
T
D
Y
Q
------------------
G
D
F
T
D
--
P
K
V
T
Q
E
D
V
D
Y
L
L
D
V
I
N
H
R
Y
P
E
A
N
I
T
L
A
D
I
E
-
A
S
W
A
--
G
L
R
P
L
L
-----------
I
G
-----------------------
S
S
L
E
R
E
P
D
G
L
L
T
--
L
-
S
G
G
---
K
---
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
R
Q
L
L
K
E
E
Y
G
I
E
T
K
E
I
D
S
K
K
Y
Q
I
S
G
G
-------
N
F
D
P
TK
L
E
E
T
V
T
E
L
A
K
E
G
V
A
A
G
L
E
E
---
E
D
A
T
Y
I
A
D
F
Y
G
T
N
A
R
R
I
F
E
L
A
K
E
M
A
P
Y
P
--
G
---
L
S
L
A
E
S
-
A
R
L
R
Y
G
L
E
E
E
M
V
L
A
P
G
D
Y
L
I
R
R
T
N
H
-
L
L
F
E
R
D
Q
L
D
E
I
K
Q
P
V
I
D
A
I
A
E
Y
F
G
W
T
E
E
E
K
A
Q
Q
T
K
R
L
E
A
L
I
A
E
S
-----------
5
PsiBlast_PDB
65.08
29%
-36
- C4 -
2R45
27
GLPD_ECOLI
A:
[27-478]
------------------------------------------
L
S
-
V
L
M
L
E
A
Q
-
D
L
--
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
---------------
P
-
H
R
---
P
H
L
----
R
P
A
W
M
I
R
I
G
L
F
M
Y
D
H
-
L
G
------
K
R
T
S
-
L
P
G
S
T
G
L
R
F
G
A
N
S
V
L
K
P
---
E
I
K
R
G
F
E
Y
S
D
-
C
-
W
V
----
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
-
G
E
V
L
T
R
T
R
A
T
-----
S
A
R
R
E
N
G
L
W
I
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
-------------
P
W
V
K
Q
F
F
D
D
-----------
G
M
H
-
L
P
--
S
-
P
Y
G
I
R
L
I
K
G
-------
S
H
I
V
V
---
P
R
-
V
H
---------
T
Q
K
Q
A
-
Y
I
L
Q
N
---
E
-
D
K
R
I
V
-
F
---
V
I
P
W
-
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
------------------
G
D
P
K
A
--
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
R
D
D
I
V
-
W
T
Y
S
--
G
V
R
P
L
C
-----------
D
D
------
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
G
K
A
P
L
L
S
--
V
-
F
G
G
---
K
---
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
-----
Y
Y
Q
G
I
G
P
A
W
T
K
E
S
V
L
P
G
G
A
I
E
G
D
R
D
D
Y
A
A
--
R
L
R
R
R
Y
P
F
--------
L
T
E
---
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
--
E
D
--
F
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
L
N
---------------------------------------------------
7
PsiBlast_PDB
64.96
29%
-34
- C4 -
2R4E
20
GLPD_ECOLI
A:
[27-478]
------------------------------------------
L
S
-
V
L
M
L
E
A
Q
-
D
L
--
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
---------------
P
-
H
R
---
P
H
L
----
R
P
A
W
M
I
R
I
G
L
F
M
Y
D
H
-
L
G
------
K
R
T
S
-
L
P
G
S
T
G
L
R
F
G
A
N
S
V
L
K
P
---
E
I
K
R
G
F
E
Y
S
D
-
C
-
W
V
----
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
-
G
E
V
L
T
R
T
R
A
T
-----
S
A
R
R
E
N
G
L
W
I
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
-------------
P
W
V
K
Q
F
F
D
D
-----------
G
M
H
-
L
P
--
S
-
P
Y
G
I
R
L
I
K
G
-------
S
H
I
V
V
---
P
R
-
V
H
---------
T
Q
K
Q
A
-
Y
I
L
Q
N
---
E
-
D
K
R
I
V
-
F
---
V
I
P
W
-
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
------------------
G
D
P
K
A
--
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
R
D
D
I
V
-
W
T
Y
S
--
G
V
R
P
L
C
-----------
D
D
------
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
G
K
A
P
L
L
S
--
V
-
F
G
G
---
K
---
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
-----
Y
Y
Q
G
I
G
P
A
W
T
K
E
S
V
L
P
G
G
A
I
E
G
D
R
D
D
Y
A
A
--
R
L
R
R
R
Y
P
F
--------
L
T
E
---
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
--
E
D
--
F
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
L
N
---------------------------------------------------
6
PsiBlast_PDB
64.67
29%
-34
- C4 -
2R46
23
GLPD_ECOLI
A:
[27-478]
------------------------------------------
L
S
-
V
L
M
L
E
A
Q
-
D
L
--
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
---------------
P
-
H
R
---
P
H
L
----
R
P
A
W
M
I
R
I
G
L
F
M
Y
D
H
-
L
G
------
K
R
T
S
-
L
P
G
S
T
G
L
R
F
G
A
N
S
V
L
K
P
---
E
I
K
R
G
F
E
Y
S
D
-
C
-
W
V
----
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
-
G
E
V
L
T
R
T
R
A
T
-----
S
A
R
R
E
N
G
L
W
I
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
-------------
P
W
V
K
Q
F
F
D
D
-----------
G
M
H
-
L
P
--
S
-
P
Y
G
I
R
L
I
K
G
-------
S
H
I
V
V
---
P
R
-
V
H
---------
T
Q
K
Q
A
-
Y
I
L
Q
N
---
E
-
D
K
R
I
V
-
F
---
V
I
P
W
-
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
------------------
G
D
P
K
A
--
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
R
D
D
I
V
-
W
T
Y
S
--
G
V
R
P
L
C
-----------
D
D
------
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
G
K
A
P
L
L
S
--
V
-
F
G
G
---
K
---
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
-----
Y
Y
Q
G
I
G
P
A
W
T
K
E
S
V
L
P
G
G
A
I
E
G
D
R
D
D
Y
A
A
--
R
L
R
R
R
Y
P
F
--------
L
T
E
---
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
--
E
D
--
F
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
L
N
---------------------------------------------------
8
PsiBlast_PDB
64.61
29%
-33
- C4 -
2R4J
22
GLPD_ECOLI
A:
[27-471]
------------------------------------------
L
S
-
V
L
M
L
E
A
Q
-
D
L
--
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
---------------
P
-
H
R
---
P
H
L
----
R
P
A
W
M
I
R
I
G
L
F
M
Y
D
H
-
L
G
------
K
R
T
S
-
L
P
G
S
T
G
L
R
F
G
A
N
S
V
L
K
P
---
E
I
K
R
G
F
E
Y
S
D
-
C
-
W
V
----
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
-
G
E
V
L
T
R
T
R
A
T
-----
S
A
R
R
E
N
G
L
W
I
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
-------------
P
W
V
----
K
Q
F
F
----
D
---
D
G
M
H
-
L
P
--
S
-
P
Y
G
I
R
L
I
K
G
-------
S
H
I
V
V
---
P
R
-
V
H
---------
T
Q
K
Q
A
-
Y
I
L
Q
N
---
E
-
D
K
R
I
V
-
F
---
V
I
P
W
-
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
------------------
G
D
P
K
A
--
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
R
D
D
I
V
-
W
T
Y
S
--
G
V
R
P
L
C
-----------
D
D
------
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
G
K
A
P
L
L
S
--
V
-
F
G
G
---
K
---
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
-----
Y
Y
Q
G
I
G
P
A
W
T
K
E
S
V
L
P
G
G
A
I
E
G
D
R
D
D
Y
A
A
--
R
L
R
R
R
Y
P
F
--------
L
T
E
---
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
--
E
D
--
F
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
----------------------------------------------------------
4
PsiBlast_PDB
64.40
29%
-33
- C4 -
2QCU
24
GLPD_ECOLI
A:
[27-478]
------------------------------------------
L
S
-
V
L
M
L
E
A
Q
-
D
L
--
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
---------------
P
-
H
R
---
P
H
L
----
R
P
A
W
M
I
R
I
G
L
F
M
Y
D
H
-
L
G
------
K
R
T
S
-
L
P
G
S
T
G
L
R
F
G
A
N
S
V
L
K
P
---
E
I
K
R
G
F
E
Y
S
D
-
C
-
W
V
----
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
-
G
E
V
L
T
R
T
R
A
T
-----
S
A
R
R
E
N
G
L
W
I
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
-------------
P
W
V
K
Q
F
F
D
D
-----------
G
M
H
-
L
P
--
S
-
P
Y
G
I
R
L
I
K
G
-------
S
H
I
V
V
---
P
R
-
V
H
---------
T
Q
K
Q
A
-
Y
I
L
Q
N
---
E
-
D
K
R
I
V
-
F
---
V
I
P
W
-
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
------------------
G
D
P
K
A
--
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
R
D
D
I
V
-
W
T
Y
S
--
G
V
R
P
L
C
-----------
D
D
------
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
G
K
A
P
L
L
S
--
V
-
F
G
G
---
K
---
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
-----
Y
Y
Q
G
I
G
P
A
W
T
K
E
S
V
L
P
G
G
A
I
E
G
D
R
D
D
Y
A
A
--
R
L
R
R
R
Y
P
F
--------
L
T
E
---
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
--
E
D
--
F
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
L
N
---------------------------------------------------
117
Fugue
56.62
23%
-29
- C3 -
4OPU
3
?
A:
[2-453]
--------------
M
K
E
L
K
Y
D
V
L
I
I
G
G
G
F
A
G
S
S
A
A
Y
Q
L
S
R
R
G
L
K
-
I
L
L
V
D
S
K
-
P
W
--
N
R
--
I
G
D
K
P
C
G
D
A
V
S
--
K
A
H
F
D
-
K
L
G
----------------------------------
M
---------------
P
Y
P
K
---
G
E
E
----
L
E
N
K
I
N
G
I
K
L
Y
S
P
D
----------------------
M
Q
T
V
W
T
V
N
H
E
---
G
F
E
L
---------------
N
A
P
L
Y
N
Q
R
V
L
K
E
A
Q
D
R
G
-
V
E
I
W
D
L
T
T
A
M
K
P
I
F
E
D
G
-
Y
V
K
G
A
V
L
F
---
N
R
R
T
N
E
E
L
T
V
Y
S
K
V
V
V
E
A
T
G
YSRSFRSKLPPEL
P
I
T
----
E
D
-
L
----
D
---
D
K
D
A
-
D
V
--
A
-
Y
R
E
V
L
L
T
K
E
D
I
E
DHD
Y
L
R
I
F
I
-
D
Q
E
T
-
S
P
---------
G
G
Y
W
W
-
Y
F
P
K
G
---
K
-
N
K
V
N
V
-
G
---
L
G
I
Q
-
G
G
M
-
G
Y
--------------------------------------
P
S
I
H
E
Y
Y
K
K
Y
L
D
K
Y
A
P
D
V
D
K
S
K
L
L
V
K
G
G
A
L
V
--
P
T
R
R
P
L
-----------
Y
T
-------------
M
A
W
------
N
G
I
I
V
I
G
D
S
G
F
T
V
NP
V
-
H
G
G
---
G
-----------------------
K
G
S
A
M
I
S
G
Y
C
A
A
K
--
A
I
L
S
A
F
E
T
G
D
F
-
S
A
S
G
--
L
W
D
M
N
I
C
Y
V
N
---
E
Y
G
A
K
Q
A
S
L
D
I
F
R
R
F
L
Q
K
L
-
S
N
D
D
I
N
Y
G
M
K
K
K
I
I
K
E
E
--
D
L
--
L
E
A
S
E
K
-
G
D
L
H
L
S
V
A
D
K
A
M
R
V
I
S
G
-
L
G
R
P
S
---
L
L
F
K
L
K
A
V
A
E
S
M
K
K
I
K
E
L
Y
L
N
Y
P
R
-
S
P
S
S
L
G
S
W
R
R
E
V
D
N
V
L
T
E
F
N
K
S
L
S
------
94
HHSearch
53.88
21%
-36
- C4 -
1RYI
2
GLOX_BACSU
A:
[14-363]
---------------
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
K
N
-
T
A
L
F
E
S
G
-
T
M
--
G
G
--
R
T
T
S
A
A
A
G
M
L
G
A
H
A
E
C
E
E
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
SGV
D
I
R
Q
H
N
G
G
M
F
K
---------------
L
A
F
S
---
E
E
---------
D
V
L
----
Q
L
R
Q
-
M
D
---
D
-
L
D
S
V
S
-
W
Y
S
K
E
E
V
L
E
K
E
P
Y
A
S
G
----
D
I
F
G
A
S
F
I
Q
D
D
V
-
H
V
----
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
-
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
-
G
E
-
A
L
F
I
K
T
P
---
S
------
G
D
V
W
A
N
H
V
V
V
A
S
G
-------------
V
W
S
----
G
M
-
F
----
F
---
K
Q
L
G
-
L
-----
N
N
A
F
L
P
V
K
G
-------
E
C
L
S
V
-
W
N
D
D
-
I
P
---------
L
-
T
K
--
T
L
Y
--------
H
D
H
C
-
Y
---
I
V
P
R
K
S
G
R
-
L
V
V
G
A
T
M
K
P
G
D
------------------
W
---
S
--
E
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
A
--
I
Q
N
M
K
V
D
-
R
F
W
A
--
G
L
R
P
G
T
-----------
K
D
------
G
K
P
---
Y
I
G
R
------
H
P
E
---
D
-
S
R
I
L
F
--
A
-
A
G
H
FRN
G
---
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Fugue
53.02
18%
-28
- C4 -
3DME
4
?
A:
[3-368]
-----------------
T
D
I
D
C
I
V
I
G
A
G
V
V
G
L
A
I
A
R
A
L
A
A
G
G
H
E
-
V
L
V
A
E
A
A
E
G
I
--
G
T
--
G
T
S
S
R
N
S
E
V
I
H
A
G
I
Y
Y
P
A
-
D
S
L
K
A
R
L
C
V
R
G
K
H
L
L
Y
E
Y
C
A
A
R
-----
G
V
-
P
H
Q
R
---------------------------------
L
G
K
L
I
V
A
T
S
D
A
E
A
S
Q
-
L
D
S
I
A
R
-
R
A
G
A
N
-
G
V
D
D
L
Q
H
I
D
G
A
A
A
R
R
L
E
---
P
A
L
H
C
T
A
A
L
V
-
S
-
P
S
T
G
I
V
D
S
H
A
L
M
L
A
Y
Q
G
D
A
E
S
D
G
-
A
Q
L
V
F
H
T
P
L
I
A
G
R
V
R
P
E
----
G
G
F
E
L
---
D
F
G
G
A
E
P
M
T
L
S
C
R
V
L
I
N
A
A
G
-------------
L
H
A
----
P
G
-
L
----
A
R
R
I
E
G
I
P
-
R
D
--
S
-
I
P
P
E
Y
L
C
K
G
-------
S
Y
F
T
L
-
A
-
G
R
-
A
P
---------
F
S
R
L
I
-
Y
P
V
P
Q
---
H
-
A
G
L
G
V
H
L
---
T
L
D
L
-
G
G
Q
-
A
K
F
G
P
D
T
E
W
I
A
--------------------
T
E
D
--
Y
T
L
D
P
R
R
A
D
V
F
Y
A
A
V
R
S
Y
W
P
A
L
P
--
D
G
A
L
A
-
P
G
Y
T
--
G
I
R
P
K
I
-----------
S
G
------
P
H
E
P
A
A
D
F
A
I
------
A
G
P
A
S
H
G
V
A
G
L
V
N
--
L
-
Y
G
I
---
E
SPG
L
T
A
S
L
A
I
A
E
E
T
L
A
R
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
HHSearch
50.60
17%
-23
- C4 -
3DME
4
?
A:
[3-368]
-----------------
T
D
I
D
C
I
V
I
G
A
G
V
V
G
L
A
I
A
R
A
L
A
A
G
G
H
E
-
V
L
V
A
E
A
A
E
G
I
--
G
T
--
G
T
S
S
R
N
S
E
V
I
H
A
G
I
Y
Y
P
A
D
S
L
K
A
R
L
C
V
R
G
K
H
L
L
Y
E
Y
C
A
A
R
G
-----
V
P
-
H
Q
R
L
G
K
L
I
---------------
V
A
T
S
---
D
A
---------
E
A
S
Q
L
D
S
I
A
R
R
-
A
G
A
-
N
G
-
V
D
D
L
Q
-
H
I
D
G
A
A
A
R
R
L
E
P
A
L
H
------
C
T
A
A
L
V
S
P
S
T
G
-
I
V
----
D
S
H
A
L
M
L
A
Y
Q
G
D
A
E
S
D
G
-
A
Q
L
V
F
H
T
P
L
I
A
G
R
V
R
-
P
E
G
G
F
E
L
D
F
G
---
G
---
A
E
P
M
T
L
S
C
R
V
L
I
N
A
A
G
-------------
L
H
A
----
P
G
-
L
----
A
---
R
R
I
E
G
I
P
RD
S
-
I
P
P
E
Y
L
C
K
G
-------
S
Y
F
T
L
-
A
G
R
A
-
P
F
---------
S
--
R
--
L
I
Y
P
V
P--
Q
H
A
G
L
G
V
-
H
---
L
T
L
D
L
G
G
Q
-
A
K
F
G
P
D
T
E
W
I
A
--------------------
T
E
D
--
Y
T
L
D
P
R
R
A
D
V
F
Y
A
A
V
R
S
Y
W
P
A
--
L
P
D
G
A
L
A
-
P
G
Y
T
--
G
I
R
P
K
I
-----------
S
G
PHEPAA
D
F
A
---
I
A
G
P
------
A
S
H
---
G
V
A
G
L
V
N
--
L
-
Y
G
I
ESP
G
---
L
T
A
S
L
A
I
A
E
E
T
L
A
R
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
HHSearch
48.59
18%
-31
* C4 *
1Y56
4
?
B:
[3-356]
----------------
P
E
K
S
E
I
V
V
I
G
G
G
I
V
G
V
T
I
A
H
E
L
A
K
R
G
E
E
-
V
T
V
I
E
K
R
-
F
I
--
G
S
--
G
S
T
F
R
C
G
T
G
I
R
Q
Q
F
--
N
D
-
E
A
N
V
R
V
M
K
R
S
V
E
L
W
K
K
Y
S
E
E
Y
G
-----
F
S
-
F
K
Q
T
G
Y
L
F
---------------
L
L
Y
D
---
D
E
E
----
V
-----
K
T
F
K
R
N
I
E
I
-
Q
N
K
--
F
-
G
V
P
T
K
-
L
I
T
P
E
E
A
K
E
I
V
P
L
L
D
I
S
---
E
V
I
A
A
S
W
N
P
T
D
G
-
K
A
----
D
P
F
E
A
T
T
A
F
A
V
K
A
K
E
Y
G
-
A
K
L
L
E
Y
T
E
V
K
G
F
L
I
E
-
N
N
E
I
K
G
V
K
T
N
---
K
------
G
I
I
K
T
G
I
V
V
N
A
T
N
-------------
A
W
A
----
N
L
-
I
----
N
---
A
M
A
G
-
I
K
--
T
-
K
I
P
I
E
P
Y
K
H
-------
Q
A
V
I
T
-
Q
P
I
K
-
R
G
---------
T
I
N
P
--
M
V
I
S
----
F
-
K
Y
G
H
A
-
Y
---
L
T
Q
T
F
H
G
G
-
I
I
G
G
I
G
Y
E
I
G
P
--------------------
T
Y
D
--
L
T
P
T
Y
E
F
L
R
E
V
S
Y
Y
F
T
K
I
I
P
A
--
L
K
N
L
L
I
L
-
R
T
W
A
--
G
Y
Y
A
K
T
-----------
P
D
------
S
N
P
---
A
I
G
R
------
I
E
E
---
L
-
N
D
Y
Y
I
--
A
-
A
G
F
SGH
G
---
F
M
M
A
P
A
V
G
E
M
V
A
E
L
I
T
K
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
48.05
23%
-22
* C5 *
4X9M
3
Y051_MYCPN
A:
[39-356]
--------------------
D
V
L
I
V
G
G
G
V
I
G
C
A
T
A
Y
E
L
S
Q
Y
K
L
K
-
V
T
L
V
E
K
H
-
H
Y
L-
A
Q
--
E
T
S
H
A
N
S
G
V
I
H
T
G
I
-----------------------
D
P
N
P
-----
H
K
-
L
T
A
K
Y
N
I
L
G
K
K
L
W
L
NTYFKRLG
F
P
R
Q
K
---
I
R
T
L
I
V
A
F
N
E
M
E
R
E
Q
L
E
V
L
K
Q
R
G
I
A
N
Q
I
N
-
L
E
D
I
Q
-
M
L
S
K
E
E
T
L
K
L
E
P
Y
V
N
P
E
IV
A
G
L
K
I
E
G
S
W
------
A
----
I
D
P
V
L
A
S
K
C
L
A
L
A
A
Q
Q
N
K
V
Q
I
C
T
N
T
E
V
T
N
I
S
----
K
Q
V
D
G
T
Y
L
V
---
W
T
N
N
E
T
T
P
S
F
K
V
K
K
I
I
D
A
A
G
-------------
H
Y
A
----
D
Y
-
L
A
H
L
A
K
---
A
D
D
F
-
E
Q
--
T
-
T
R
-----
R
G
-------
Q
Y
V
V
V
T
N
Q
G
E
-
L
H
---------
L
N
S
M
V
-
F
M
V
P
T
---
I
-
H
G
K
G
V
-
I
---
V
S
P
M
L
D
G
N
-
F
L
V
G
P
T
A
L
D
G
V
------------------
D
K
E
A
T
--
R
Y
I
T
K
D
A
P
C
M
L
T
K
I
G
K
H
M
V
P
S
L
N
I
N
N
A
L
I
---
S
F
A
--
G
S
R
P
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
47.93
23%
-23
- C5 -
4X9N
2
Y051_MYCPN
A:
[39-356]
--------------------
D
V
L
I
V
G
G
G
V
I
G
C
A
T
A
Y
E
L
S
Q
Y
K
L
K
-
V
T
L
V
E
K
H
-
H
Y
L-
A
Q
--
E
T
S
H
A
N
S
G
V
I
H
T
G
I
-----------------------
D
P
N
P
-----
H
K
-
L
T
A
K
Y
N
I
L
G
K
K
L
W
L
N
TYFKRLG
F
P
R
Q
K
---
I
R
T
L
I
V
A
F
N
E
M
E
R
E
Q
L
E
V
L
K
Q
R
G
I
A
N
Q
I
N
-
L
E
D
I
Q
-
M
L
S
K
E
E
T
L
K
L
E
P
Y
V
N
P
E
IV
A
G
L
K
I
E
G
S
W
------
A
----
I
D
P
V
L
A
S
K
C
L
A
L
A
A
Q
Q
N
K
V
Q
I
C
T
N
T
E
V
T
N
I
S
----
K
Q
V
D
G
T
Y
L
V
---
W
T
N
N
E
T
T
P
S
F
K
V
K
K
I
I
D
A
A
G
-------------
H
Y
A
----
D
Y
-
L
A
H
L
A
K
---
A
D
D
F
-
E
Q
--
T
-
T
R
-----
R
G
-------
Q
Y
V
V
V
T
N
Q
G
E
-
L
H
---------
L
N
S
M
V
-
F
M
V
P
T
---
I
-
H
G
K
G
V
-
I
---
V
S
P
M
L
D
G
N
-
F
L
V
G
P
T
A
L
D
G
V
------------------
D
K
E
A
T
--
R
Y
I
T
K
D
A
P
C
M
L
T
K
I
G
K
H
M
V
P
S
L
N
I
N
N
A
L
I
---
S
F
A
--
G
S
R
P
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
46.53
17%
-24
- C4 -
1PJ5
3
DMGO_ARTGO
A:
[4-425]
------------------
T
P
R
I
V
I
I
G
A
G
I
V
G
T
N
L
A
D
E
L
V
T
R
G
W
N
N
I
T
V
L
D
Q
G
-
P
L
NM
P
G
--
G
S
T
S
H
A
P
G
L
V
F
Q
T
N
P
--
S
-
K
T
M
A
S
F
A
K
Y
T
V
E
K
L
L
S
L
T
E
D
G
V
-----
S
C
-
F
N
Q
V
G
G
L
E
---------------
V
A
T
T
---
E
T
---------
R
L
A
D
L
K
R
K
L
G
Y
-
A
A
A
--
W
-
G
I
E
G
R
-
L
L
S
P
A
E
C
Q
E
L
Y
P
L
L
D
G
E
---
N
I
L
G
G
L
H
V
P
S
D
G
-
L
A
----
S
A
A
R
A
V
Q
L
L
I
K
R
T
E
S
A
G
-
V
T
Y
R
G
S
T
T
V
T
G
I
E
Q
S
-
G
G
R
V
T
G
V
Q
T
A
---
D
------
G
V
I
P
A
D
I
V
V
S
C
A
G
-------------
F
W
G
----
A
K
-
I
----
G
---
A
M
I
G
-
M
-----
A
V
P
L
L
P
L
A
H
-------
Q
Y
V
K
T
-
T
P
V
P
-
A
Q
QGRNDQPNG
A
R
L
P
--
I
L
R
H
------
Q
D
Q
D
L
-
Y
---
Y
R
E
H
-
G
D
R
-
Y
G
I
G
S
Y
A
H
R
P
M
P
V
DVDTLGAYAPETVSEH
H
M
P
S
R
--
L
D
F
T
L
E
D
F
L
P
A
W
E
A
T
K
Q
L
L
P
A
--
L
A
D
S
E
I
E
-
D
G
F
N
--
G
I
F
S
F
T
-----------
P
D
------
G
G
P
---
L
L
G
E
------
S
K
E
L
----
D
G
F
Y
V
--
A
-
E
A
V
---
W
---
V
T
H
S
A
G
V
A
K
A
M
A
E
L
L
T
T
G
R
S
E
T
--------
D
L
G
E
C
D
I
T
R
F
E
D
V
-----------------
Q
L
T
---
P
E
Y
V
S
E
---
T
S
Q
Q
N
F
V
E
I
Y
D
V
L
H
P
L
Q
P
R
L
------------------------------------------------------------------------------------------------------
108
HHSearch
46.29
17%
-33
- C4 -
2OLN
3
?
A:
[3-375]
-----------------
E
S
Y
D
V
V
V
V
G
G
G
P
V
G
L
A
T
A
W
Q
V
A
E
R
G
H
R
-
V
L
V
L
E
R
H
-
T
F
--
F
N
EN
G
G
T
S
G
A
E
R
H
W
R
--
L
Q
Y
T
Q
-
E
D
L
F
R
L
T
L
E
T
L
P
L
W
R
A
L
E
S
R
C
E
R----
R
L
-
I
H
E
I
G
S
L
W
---------------
F
G
D
T
---
D
V
V
----
T
N
---
E
G
Q
I
S
G
T
A
A
M
-
M
D
K
--
L
-
S
V
R
Y
E
-
W
L
K
A
T
D
I
E
R
R
F
G
F
R
G
L
P
---
R
D
Y
E
G
F
L
Q
P
D
-
G
G
T
I
----
D
V
R
G
T
L
A
A
L
F
T
L
A
Q
A
A
G
-
A
T
L
R
A
G
E
T
V
T
E
L
V
P
D
-
A
D
-
G
V
S
V
T
T
D
---
R
------
G
T
Y
R
A
G
K
V
V
L
A
C
G
-------------
P
Y
T
----
N
D
-
L
----
L
---
E
P
L
G
-
A
-----
R
L
A
Y
S
V
Y
E
M
-------
A
I
A
A
Y
-
R
Q
A
T
P
V
T
---------
E
-
A
P
F
W
F
A
F
Q
Q
P
TP
Q
-
D
T
N
L
F
-
Y
G
FG
H
N
P
W
A
P
G
E
F
V
R
C
G
P
D
F
E
V
D
P
L-----------------
D
H
P
S
A
AT
G
V
A
D
R
R
Q
M
D
R
L
S
G
W
L
R
D
H
L
P
T
--
V
D
P
-
D
P
V
-
R
T
S
T
C
L
A
V
L
P
T
D
-----------
P
E
------
R
Q
F
---
F
L
G
T
------
A
R
D
L
M
T
H
G
E
K
L
V
V
--
Y
G
A
G
W
---
A
---
F
K
F
V
P
L
F
G
R
I
C
A
D
L
A
V
E
D
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------