@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1374: (2016-03-25 )
MKILFQEIINKAIEMKASDVHFIPVKNEVSIKFRINDNLEQYEQIGNSIYQKLLVYMKFQAGLDVSTQQVAQSGRYSYHFNKIYFLRISTLPLSLGQESCVIRIVPQFFQQQKSTYKFNDFKHLMNKKQGLLLFSGPTGSGKSTLMYQMVSYANKALNLNVISIEDPVEMQIPGIVQINVNDKAGINYVNSFKAILRCDPDVILIGEIRDKDVAKCVIQASLSGHLVLTTLHATDCKGAILRLLEMGISVQELIQATNLIINQRLVTTIKQQRQLVCEILSQQQLRYFFSHNHSLPSSFKNLEDKLDDMTKAGVICETTMDKYI
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------.........10........20...-----..----...30....-....40..-----.---..-...50........60.......------.70........80--.......-.90--...-.-.--...100.....------..110.---.------.-..------.----------------------...120.......130.......140.......150.......160.......170.---.----.-------....180...---..---..190.......200.......210.......220....-...230.......240..------..-...------------250----.......-----..-260......----.-----------270-----------------------------------........280.......290.------------.-----------.....300.......310.......320..-------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------MK
I
L
F
Q
E
I
I
N
K
A
I
EMKAS
D
V
H
F
I
P-----VK----N
E
V
S
I
K
F
R
I-ND
N
L
E
Q
Y
E
-----
Q
---
I
G
-
N
S
I
Y
Q
K
L
L
V
Y
M
K
FQAGLD
V
S
T
Q
------
Q
V
A
Q
SG
R
Y
S
Y
H
F
N
--
K
I
Y
F
L
R
I
-STL--PLS-L-G--QE
S
C
V
I
R
I
V
P
Q
------
F
F
Q
--
Q
---
Q
------K-ST------Y----------------------K
F
N
D
F
K
H
L
MNKKQ
G
L
L
L
F
SGPTGSG
K
S
T
L
M
Y
Q
M
V
S
YANK
A
L
N
L
N
V
I
SIEDPVEMQI
P
---
G
----
I
-------
V
Q
I
NVNDKAG---
I
N
---
Y
V
N
S
F
K
A
I
L
RCDP
D
V
I
L
I
G
EIR
D
K
D
V
A
K
C
V
I
Q
ASLSG
H
L
-
V
L
T
T
LHATD
C
K
G
A
I
L
R
L
L
------
E
M-GI
S
------------
V
------
Q
E
L
I
Q
A
T
-----
N
L
-
I
I
N
Q
R
L
V
T
T
----
I
-----------
K
Q
------------------------------------
Q
R
Q
L
V
C
E
I
L
S
Q
Q
Q
L
R
Y
F
F
SHNH------------S-----------L
P
S
S
F
K
N
L
E
D
K
L
D
D
M
T
KAG
V
I
C
E
T
T
M
D
KYI-------------------------------------------------------------
28
HHSearch
96.14
31%
-116
- C3 -
1P9R
2
GSPE_VIBCH
A:
[34-410]
---------------------------------------------------------------------------------------------------------------------
I
K
L
I
N
A
M
L
G
E
A
I
K
E
G
A
S
D
I
H
I
E
T
-----
F
E
----
K
T
L
S
I
R
F
R
V
-
D
G
V
L
R
E
V
L
-----
A
---
P
S
-
R
K
L
S
S
L
L
V
S
R
V
K
V
M
A
K
L
D
I
A
E
K
------
R
V
P
Q
D
G
R
I
S
L
------
A
V
D
V
R
V
-
S
T
M
--
P
S
S
---
H
--
G
E
R
V
V
M
R
L
L
D
K
------
N
A
T
RL
D
---
L
HSL---
G
M
T
A
------
H
----------------------
N
H
D
N
F
R
R
L
I
K
R
P
H
G
I
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
N
S
-
S
E
R
N
I
L
T
V
E
D
P
I
E
F
D
I
D
---
G
----
I
-------
G
Q
T
Q
V
N
P
R
V
D
---
M
T
---
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
-
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
------
D
M
-
G
I
E
------------
P
------
F
L
I
S
S
S
L
-----
L
G
-
V
L
A
Q
R
L
V
R
T
----
L
-----------
C
P
DC
K
E
P
Y
E
A
D
K
E
Q
R
K
L
FE
P
L
I
L
Y
R
A
T
G
C
PKCNHKGY
R
G
R
T
G
I
H
E
L
L
L
V
D
D
A
L
Q
E
L
I
H
S
E
------------
A
G
E
Q
A
M
E
K
H
---
I
R
A
T
T
P
S
I
R
D
D
G
L
D
K
V
R
Q
G
I
T
S
L
E
E
V
M
R
G
S
-------------------------------------------------------------
5
PsiBlast_PDB
95.37
34%
-140
- C3 -
1P9W
2
GSPE_VIBCH
A:
[36-328]
-----------------------------------------------------------------------------------------------------------------------
L
I
N
A
M
L
G
E
A
I
K
E
G
A
S
D
I
H
I
E
T
-----
F
E
----
K
T
L
S
I
R
F
R
V
-
D
G
V
L
R
E
V
L
-----
A
---
P
S
-
R
K
L
S
S
L
L
V
S
R
V
K
V
M
A
K
L
D
I
A
E
K
------
R
V
P
Q
D
G
R
I
S
L
R
I
G
---
A
V
D
V
R
V
-
S
T
M
--
P
S
S
-
H
-
G
---
E
R
V
V
M
R
L
L
D
K
NATRLD
L
H
S
--
L
---
G
------
M
-
T
A
------
H
----------------------
N
H
D
N
F
R
R
L
I
K
R
P
H
G
I
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
N
S
S
-
E
R
N
I
L
T
V
E
D
P
I
E
F
D
I
D
---
G
----
I
-------
G
Q
T
Q
V
N
P
R
V
D
---
M
T
---
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
-
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
------
D
M
-
G
I
E
-------------------
P
F
L
I
S
S
S
-----
L
L
G
V
L
A
Q
R
L
V
R
T
----
L
CPDC
K
E
P
Y
E
A
D
K
E
------------------------------------
Q
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
93.26
34%
-135
- C3 -
1P9R
2
GSPE_VIBCH
A:
[36-328]
-----------------------------------------------------------------------------------------------------------------------
L
I
N
A
M
L
G
E
A
I
K
E
G
A
S
D
I
H
I
E
T
-----
F
E
----
K
T
L
S
I
R
F
R
V
-
D
G
V
L
R
E
V
L
-----
A
---
P
S
-
R
K
L
S
S
L
L
V
S
R
V
K
V
M
A
K
L
D
I
A
E
K
------
R
V
P
Q
D
G
R
I
S
L
------
A
V
D
V
R
V
-
S
T
M
--
P
S
S
-
H
-
G
---
E
R
V
V
M
R
L
L
D
K
NATRLD
L
H
S
--
L
---
G
------
M
-
T
A
------
H
----------------------
N
H
D
N
F
R
R
L
I
K
R
P
H
G
I
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
N
S
S
-
E
R
N
I
L
T
V
E
D
P
I
E
F
D
I
D
---
G
----
I
-------
G
Q
T
Q
V
N
P
R
V
D
---
M
T
---
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
-
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
------
D
M
-
G
I
E
-------------------
P
F
L
I
S
S
S
-----
L
L
G
V
L
A
Q
R
L
V
R
T
----
L
CPDC
K
E
P
Y
E
A
D
K
E
------------------------------------
Q
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.01
34%
-131
- C3 -
4KSR
-
GSPE_VIBCH
A:
[28-337]
-----------------------------------------------------------------------------------------------------------------------
L
I
N
A
M
L
G
E
A
I
K
E
G
A
S
D
I
H
I
E
T
-----
F
E
----
K
T
L
S
I
R
F
R
V
-
D
G
V
L
R
E
V
L
-----
A
---
P
S
-
R
K
L
S
S
L
L
V
S
R
V
K
V
M
A
K
L
D
I
A
E
K
------
R
V
P
Q
D
G
R
I
S
L
------
A
V
D
V
R
V
-
S
T
M
--
P
S
S
-
H
-
G
---
E
R
V
V
M
R
L
L
D
K
D-----
L
H
S
--
L
---
G
------
M
-
T
A
------
H
----------------------
N
H
D
N
F
R
R
L
I
K
R
P
H
G
I
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
N
S
S
-
E
R
N
I
L
T
V
E
D
P
I
E
F
D
I
D
---
G
----
I
-------
G
Q
T
Q
V
N
P
R
V
D
---
M
T
---
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
-
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
------
D
M
-
G
I
E
-------------------
P
F
L
I
S
S
S
-----
L
L
G
V
L
A
Q
R
L
V
R
T
----
L
CPD
C
K
E
P
Y
E
A
D
K
E
------------------------------------
Q
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.40
36%
-130
- C3 -
4PHT
3
?
A:
[123-401]
-----------------------------------------------------------------------------------------------------------------------
L
I
N
A
M
L
G
E
A
I
K
E
G
A
S
D
I
H
I
E
T
-----
F
E
----
K
I
L
S
I
R
F
R
V
-
D
G
V
L
R
D
V
L
-----
S
---
P
S
-
R
K
L
A
P
L
L
V
S
R
V
K
V
M
A
K
L
D
I
A
E
K
------
R
V
P
Q
D
G
R
I
S
L
------
A
V
D
V
R
V
-
S
T
M
--
P
S
S
-
H
-
G
---
E
R
V
V
M
R
L
L
D
K
NATRLD
L
H
S
--
L
---
G
------
M
-
T
P
------
V
----------------------
N
H
D
N
F
R
H
L
I
S
R
P
H
G
I
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
N
S
N
-
E
R
N
I
L
T
V
E
D
P
I
E
F
D
I
D
---
G
----
I
-------
G
Q
T
Q
V
N
P
K
V
D
---
M
T
---
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
-
V
M
S
T
L
H
T
N
T
A
V
G
A
I
T
R
L
R
------
D
M
-
G
I
E
-------------------
P
F
L
I
S
S
S
-----
L
L
G
V
L
A
Q
R
L
V
R
T
----
L
-----------
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
91.08
36%
-130
- C3 -
4PHT
3
?
B:
[123-400]
-----------------------------------------------------------------------------------------------------------------------
L
I
N
A
M
L
G
E
A
I
K
E
G
A
S
D
I
H
I
E
T
-----
F
E
----
K
I
L
S
I
R
F
R
V
-
D
G
V
L
R
D
V
L
-----
S
---
P
S
-
R
K
L
A
P
L
L
V
S
R
V
K
V
M
A
K
L
D
I
A
E
K
------
R
V
P
Q
D
G
R
I
S
L
------
A
V
D
V
R
V
-
S
T
M
--
P
S
S
-
H
-
G
---
E
R
V
V
M
R
L
L
D
K
NATRLD
L
H
S
--
L
---
G
------
M
-
T
P
------
V
----------------------
N
H
D
N
F
R
H
L
I
S
R
P
H
G
I
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
N
S
N
-
E
R
N
I
L
T
V
E
D
P
I
E
F
D
I
D
---
G
----
I
-------
G
Q
T
Q
V
N
P
K
V
D
---
M
T
---
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
-
V
M
S
T
L
H
T
N
T
A
V
G
A
I
T
R
L
R
------
D
M
-
G
I
E
-------------------
P
F
L
I
S
S
S
-----
L
L
G
V
L
A
Q
R
L
V
R
T
----
L
-----------
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
90.93
36%
-128
- C3 -
4PHT
3
?
C:
[123-400]
-----------------------------------------------------------------------------------------------------------------------
L
I
N
A
M
L
G
E
A
I
K
E
G
A
S
D
I
H
I
E
T
-----
F
E
----
K
I
L
S
I
R
F
R
V
-
D
G
V
L
R
D
V
L
-----
S
---
P
S
-
R
K
L
A
P
L
L
V
S
R
V
K
V
M
A
K
L
D
I
A
E
K
------
R
V
P
Q
D
G
R
I
S
L
------
A
V
D
V
R
V
-
S
T
M
--
P
S
S
-
H
-
G
---
E
R
V
V
M
R
L
L
D
K
NATRLD
L
H
S
--
L
---
G
------
M
-
T
P
------
V
----------------------
N
H
D
N
F
R
H
L
I
S
R
P
H
G
I
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
N
S
N
-
E
R
N
I
L
T
V
E
D
P
I
E
F
D
I
D
---
G
----
I
-------
G
Q
T
Q
V
N
P
K
V
D
---
M
T
---
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
-
V
M
S
T
L
H
T
N
T
A
V
G
A
I
T
R
L
R
------
D
M
-
G
I
E
-------------------
P
F
L
I
S
S
S
-----
L
L
G
V
L
A
Q
R
L
V
R
T
----
L
-----------
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.67
34%
-127
- C3 -
4KSS
-
GSPE_VIBCH
A:
[28-335]
-----------------------------------------------------------------------------------------------------------------------
L
I
N
A
M
L
G
E
A
I
K
E
G
A
S
D
I
H
I
E
T
-----
F
E
----
K
T
L
S
I
R
F
R
V
-
D
G
V
L
R
E
V
L
-----
A
---
P
S
-
R
K
L
S
S
L
L
V
S
R
V
K
V
M
A
K
L
D
I
A
E
K
------
R
V
P
Q
D
G
R
I
S
L
------
A
V
D
V
R
V
-
S
T
M
--
P
S
S
-
H
-
G
---
E
R
V
V
M
R
L
L
D
K
D-----
L
H
S
--
L
---
G
------
M
-
T
A
------
H
----------------------
N
H
D
N
F
R
R
L
I
K
R
P
H
G
I
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
N
S
S
-
E
R
N
I
L
T
V
E
D
P
I
E
F
D
I
D
---
G
----
I
-------
G
Q
T
Q
V
N
P
R
V
D
---
M
T
---
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
-
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
------
D
M
-
G
I
E
-------------------
P
F
L
I
S
S
S
-----
L
L
G
V
L
A
Q
R
L
V
R
T
----
L
CPD
C
K
E
P
Y
E
A
D
K
E
------------------------------------
Q
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
83.98
27%
-111
- C3 -
2EWV
1
?
A:
[12-351]
---------------------------------------------------------------------------------------------------------------------
E
L
K
I
L
E
I
I
K
E
A
I
E
L
G
A
S
D
I
H
L
T
A
-----
G
A
-------
P
P
A
V
R
I
-
D
G
Y
I
K
F
L
K
-----
D
FPR
L
T
-
P
E
D
T
Q
K
L
A
Y
S
V
M
S
--
E
K
--
H
R
Q
------
K
L
E
E
N
G
Q
V
D
F
S
F
G
V
R
G
V
G
R
F
R
A
-
N
V
F
--
Y
Q
R
---
G
--
S
V
A
A
A
L
R
S
L
P
A
------
E
I
P
--
E
---
F
KKL---
G
-
L
P
------
D
-------------------------
K
V
L
E
L
C
H
R
K
M
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
I
D
Y
I
N
Q
T
K
S
Y
H
I
I
T
I
E
D
P
I
E
Y
V
F
K
---
H
KK
S
I
V
-------
N
Q
R
E
V
G
E
D
-
T
---
K
S
---
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
------
D
I
-
F
P
L
------------
N
Q
Q
E
Q
V
R
I
V
L
S
F
I
L
-----
Q
G
-
I
I
S
Q
R
L
L
P
K
----
I
-----------
G
G
------------------------------------
G
R
V
L
A
Y
E
L
L
I
P
N
T
A
I
R
N
L
I
R
E
N
------------
K
L
Q
Q
V
Y
S
L
MQ------
M
Q
T
M
N
Q
T
L
Y
K
L
Y
K
Q
G
L
I
T
L
E
D
A
M
E
A
--------------------------------------------------------------
8
PsiBlast_PDB
81.77
29%
-111
- C3 -
2EWW
1
?
A:
[13-303]
--------------------------------------------------------------------------------------------------------------------
L
K
I
L
--
E
I
I
K
E
A
I
E
L
G
A
S
D
I
H
L
T
A
GA
P
P
A
V
R
----
I
D
G
Y
I
K
F
------
L
K
D
F
P
-----
R
---
L
T
-
P
E
D
T
Q
K
L
----
A
Y
S
V
M
S
E
K
H
R
Q
------
K
L
E
E
N
G
Q
V
D
F
S
F
G
--
V
R
G
V
G
R
F
R
A
N
V
--
F
Y
Q
-
R
-
G
--
S
V
A
A
A
L
R
S
L
P
A
------
E
I
P
--
E
---
F
------
K
-
K
L
------
G
----------------------
L
P
D
K
V
L
E
L
C
H
R
K
M
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
I
D
Y
I
N
Q
T
K
S
Y
H
I
I
T
I
E
D
P
I
E
Y
V
F
K
---
H
----
K
-------
K
S
I
V
N
Q
R
E
V
G
---
E
D
TKS
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
------
D
I
F
P
L
N
------------
Q
------
Q
E
Q
V
R
I
V
L
S
F
I
L
Q
G
-
I
I
S
Q
R
L
L
P
K
----
I
-----------
G
G
------------------------------------
G
R
V
L
A
Y
E
L
L
--------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
81.43
23%
-110
- C3 -
3JVV
3
PILT_PSEAE
A:
[2-337]
-----------------------------------------------------------------------------------------------------------------------
D
I
T
E
L
L
A
F
S
A
K
Q
G
A
S
D
L
H
L
S
A
-----
G
L
-------
P
P
M
I
R
V
-
D
G
D
V
R
R
I
N
-----
L
PP-
L
E
-
H
K
Q
V
H
A
L
I
Y
D
I
M
N
D
K
Q
R
K
D
F
E
E
------
F
L
E
T
D
--
F
S
F
E
V
P
--
G
V
A
R
F
R
V
-
N
A
F
--
N
Q
N
-
R
----
G
A
G
A
V
F
R
T
I
P
S
------
K
V
L
--
T
---
M
EEL---
G
-
M
G
------
E
-------------------------
V
F
K
R
V
S
D
V
P
R
G
L
V
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
M
L
D
Y
L
N
N
T
K
Y
H
H
I
L
T
I
E
D
P
I
E
F
V
H
E
---
S
KKCL
V
-------
N
Q
R
E
V
H
R
-
D
T
---
L
G
---
F
S
E
A
L
R
S
A
L
R
E
D
P
D
I
I
L
V
G
E
M
R
D
L
E
T
I
R
L
A
L
T
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
T
S
A
A
K
T
I
D
R
V
V
------
D
V
-
F
P
A
EE
K
A
M
V
------
R
------
S
M
L
S
E
S
L
-----
Q
S
-
V
I
S
Q
T
L
I
K
K
-------------------------------------------------------
R
V
A
A
H
E
I
M
I
G
T
P
A
I
R
N
L
I
R
E
D
------------
K
VAQ
M
Y
S
A
I
Q
T
G
G
S
L
G
M
Q
T
L
D
M
C
L
K
G
-------
S
R
E
N
A
R
E
K
--------------------------------------------------------------
6
PsiBlast_PDB
80.68
29%
-104
- C3 -
2EWV
1
?
A:
[13-303]
--------------------------------------------------------------------------------------------------------------------
L
K
I
L
--
E
I
I
K
E
A
I
E
L
G
A
S
D
I
H
L
T
A
GAP
P
A
V
R
----
I
D
G
Y
I
K
F
------
L
K
D
F
P
-----
R
---
L
T
-
P
E
D
T
Q
K
L
----
A
Y
S
V
M
S
E
K
H
R
Q
------
K
L
E
E
N
G
Q
V
D
F
S
F
G
--
V
R
G
V
G
R
F
R
A
N
V
--
F
Y
Q
-
R
-
G
--
S
V
A
A
A
L
R
S
L
P
A
------
E
I
P
--
E
---
F
------
K
-
K
L
------
G
----------------------
L
P
D
K
V
L
E
L
C
H
R
K
M
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
I
D
Y
I
N
Q
T
K
S
Y
H
I
I
T
I
E
D
P
I
E
Y
V
F
K
---
H
----
K
-------
K
S
I
V
N
Q
R
E
V
G
---
E
D
TKS
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
------
D
I
F
P
L
N
------------
Q
------
Q
E
Q
V
R
I
V
L
S
F
I
L
Q
G
-
I
I
S
Q
R
L
L
P
K
----
I
-----------
G
G
------------------------------------
G
R
V
L
A
Y
E
L
L
--------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.29
29%
-103
- C3 -
2GSZ
-
?
A:
[2-292]
--------------------------------------------------------------------------------------------------------------------
L
K
I
L
--
E
I
I
K
E
A
I
E
L
G
A
S
D
I
H
L
T
A
GA
P
P
A
V
R
----
I
D
G
Y
I
K
F
------
L
K
D
F
P
-----
R
---
L
T
-
P
E
D
T
Q
K
L
----
A
Y
S
V
M
S
E
K
H
R
Q
------
K
L
E
E
N
G
Q
V
D
F
S
F
G
--
V
R
G
V
G
R
F
R
A
N
V
--
F
Y
Q
-
R
-
G
--
S
V
A
A
A
L
R
S
L
P
A
------
E
I
P
--
E
---
F
------
K
-
K
L
------
G
----------------------
L
P
D
K
V
L
E
L
C
H
R
K
M
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
I
D
Y
I
N
Q
T
K
S
Y
H
I
I
T
I
E
D
P
I
E
Y
V
F
K
---
H
----
K
-------
K
S
I
V
N
Q
R
E
V
G
---
E
D
TKS
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
------
D
I
F
P
L
N
------------
Q
------
Q
E
Q
V
R
I
V
L
S
F
IL
Q
G
-
I
I
S
Q
R
L
L
P
K
----
I
-----------
G
G
------------------------------------
G
R
V
L
A
Y
E
L
L
--------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.80
28%
-111
- C3 -
3JVV
3
PILT_PSEAE
A:
[71-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
E
V
P
--
G
V
A
R
F
R
V
-
N
A
F
--
N
Q
N
-
R
-
G
--
A
-
G
A
V
F
R
T
I
P
S
------
K
V
L
--
T
---
M
------
E
-
E
L
------
G
----------------------
M
G
E
V
F
K
R
V
S
D
V
P
R
G
L
V
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
M
L
D
Y
L
N
N
T
K
Y
H
H
I
L
T
I
E
D
P
I
E
F
V
H
E
---
S
KKC-
L
-------
V
N
Q
R
E
V
H
R
D
T
---
L
G
---
F
S
E
A
L
R
S
A
L
R
E
D
P
D
I
I
L
V
G
E
M
R
D
L
E
T
I
R
L
A
L
T
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
T
S
A
A
K
T
I
D
R
V
V
D
V
FPAE
E
K
-
A
M
V
------------
R
------
S
M
L
S
E
S
L
-----
Q
S
-
V
I
S
Q
T
L
I
K
K
-------------------------------------------------------
R
V
A
A
H
E
I
M
--------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
73.27
28%
-105
- C3 -
3JVU
2
PILT_PSEAE
A:
[71-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
E
V
P
--
G
V
A
R
F
R
V
-
N
A
F
--
N
Q
N
-
R
-
G
--
A
-
G
A
V
F
R
T
I
P
S
------
K
V
L
--
T
---
M
------
E
-
E
L
------
G
----------------------
M
G
E
V
F
K
R
V
S
D
V
P
R
G
L
V
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
M
L
D
Y
L
N
N
T
K
Y
H
H
I
L
T
I
E
D
P
I
E
F
V
H
E
---
S
KKC-
L
-------
V
N
Q
R
E
V
H
R
D
T
---
L
G
---
F
S
E
A
L
R
S
A
L
R
E
D
P
D
I
I
L
V
G
E
M
R
D
L
E
T
I
R
L
A
L
T
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
T
S
A
A
K
T
I
D
R
V
V
D
V
FPAE
E
K
-
A
M
V
------------
R
------
S
M
L
S
E
S
L
-----
Q
S
-
V
I
S
Q
T
L
I
K
K
------------------------------------------------------
G
R
V
A
A
H
E
I
M
--------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
72.16
30%
-108
- C3 -
2EYU
-
?
A:
[19-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
C
H
R
K
M
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
I
D
Y
I
N
Q
T
K
S
Y
H
I
I
T
I
E
D
P
I
E
Y
V
F
K
---
H
KK
S
I
V
-------
N
Q
R
E
V
G
E
-
D
T
---
K
S
---
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
------
D
I
-
F
P
L
------------
N
Q
Q
E
Q
V
R
I
V
L
S
F
I
L
-----
Q
G
-
I
I
S
Q
R
L
L
P
K
----
I
-----------
G
G
------------------------------------
G
R
V
L
A
Y
G
L
L
I
P
N
T
A
I
R
N
L
I
R
E
N
K
L
Q
Q
V
Y
S
L
M
Q
S
G
Q
-----------
A
E
T
G
M
Q
T
M
N
Q
T
L
Y
K
L
Y
K
Q
G
L
I
T
L
E
D
A
M
E
A
S
-------------------------------------------------------------
11
PsiBlast_PDB
69.96
34%
-112
- C3 -
2EYU
-
?
A:
[20-185]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
H
R
K
M
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
I
D
Y
I
N
Q
T
K
S
Y
H
I
I
T
I
E
D
P
I
E
Y
V
F
K
---
H
----
K
-------
K
S
I
V
N
Q
R
E
V
G
---
E
D
TKS
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
------
D
I
F
P
L
N
------------
Q
------
Q
E
Q
V
R
I
V
L
S
F
IL
Q
G
-
I
I
S
Q
R
L
L
P
K
----
I
-----------
G
G
------------------------------------
G
R
V
L
A
Y
G
L
L
--------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
68.19
20%
-111
- C3 -
2GZA
2
VIRBB_BRUSU
A:
[26-345]
------------------------------------------------------------------------------------------------------------------------
L
E
P
L
R
P
W
L
D
D
P
Q
I
T
E
V
C
V
N
R
-----
P
G
-------
E
V
F
C
E
R
-
A
S
A
W
E
Y
Y
A
V
P---
N
---
L
D
-
Y
E
H
L
I
S
L
G
T
A
T
A
R
F
V
D
Q
D
I
S
D
S
------
R
-
P
---
V
L
S
A
I
L
----
P
M
G
E
R
I
-
Q
I
V
R
-
P
P
A
C
E
H
G
--
T
I
S
V
T
I
R
K
P
S
F
------
T
R
R
--
T
---
L
E
D
Y
A
Q
Q
G
F
F
K
------
H
VRPMSKSLT
P
F
E
Q
E
L
L
A
L
K
E
A
G
D
Y
M
S
F
L
R
R
A
V
Q
L
E
R
V
I
V
V
A
G
E
T
G
S
G
K
T
T
L
M
K
A
L
M
Q
E
I
P
F
--
D
Q
R
L
I
T
I
E
D
V
P
E
L
F
L
P
---
D
----
H
PN
H
V
H
L
F
Y
P
-----------
V
T
---
A
A
T
L
L
R
S
C
L
R
M
K
P
T
R
I
L
L
A
E
L
R
G
G
E
-
A
Y
D
F
I
N
V
A
A
S
G
H
G
G
S
I
T
S
C
H
A
G
S
C
E
L
T
F
E
R
L
A
------
L
M
-
V
L
Q
N
R
Q
G
R
Q
LP
Y
E
I
I
R
------
R
L
L
Y
L
V
V
-----
D
V
-
V
V
H
V
H
N
G
V
H
----
D
-----------
G
T
-------------------------------------
G
R
H
I
S
E
V
W
Y
-------------------------------------------------------------------------------------------------------------------------------
53
Fugue
68.13
21%
-82
- C3 -
4IHQ
5
?
A:
[2-513]
S
F
V
E
D
Y
L
T
K
LQ
E
R
P
T
I
I
ENPNILKGSKI
F
N
A
I
Y
R
V
D
DF
V
Y
I
H
I
Q
SIKSEDG
Y
N
Q
Y
N
V
I
E
P
P
RPT
H
D
E
M
E
E
I
E
E
K
F
A
L
S
IGD
K
E
P
P
ED
T
K
E
K
E
K
L
I
R
S
I
L
D
K
I
L
L
RMRLSVP
K
E
Y
V
I
Y
H
F
I
R
D
K
L
Y
T
G
S
L
E
P
L
I
R
D
P
Y
I
E
D
-----
I
S
IPGL
G
H
V
Y
I
V
H
K
V
-
F
G
P
M
R
T
S
I
-----
K
---
F
E
N
Y
E
E
L
D
N
L
I
V
S
L
S
E
K
S
Y
R
P
V
S
H
N
RP
V
V
D
A
S
L
P
D
G
S
R
V
N
F
V
Y
G
--
V
D
I
S
R
R
G
-
S
N
L
--
T
V
R
-
K
-
F
--
S
R
V
P
T
S
--
I
T
Q
------
L
I
M
--
F
---
G
------
T
-
L
S
------
S
----------------------
M
M
A
A
Y
I
W
T
M
L
D
E
G
M
N
L
F
V
C
G
E
T
A
S
G
K
T
T
T
L
N
A
I
T
A
F
I
P
P
--
N
L
K
I
V
T
I
E
D
T
P
E
L
T
V
P
HS-
N
----
W
-------
V
A
E
V
T
R
E
T
G
G
EGT
I
K
---
L
F
D
L
L
K
A
A
L
R
Q
R
P
N
Y
I
L
V
G
A
I
R
D
K
-
E
G
N
V
A
F
Q
A
M
Q
T
G
H
S
-
V
M
A
T
F
H
A
A
N
I
T
T
L
I
Q
R
L
T
------
G
Y
-
P
I
E
------------
V
P-----
K
S
Y
I
N
N
L
-----
N
I
-
A
L
F
Q
T
A
L
Y
D
KKG
N
L
-----------
I
R
------------------------------------
R
V
V
E
V
D
E
I
I
D
I
D
P
-----
V
T
N
D
------------
V
-----------
V
Y
I
P
A
F
T
Y
D
S
V
Q
D
K
M
L
F
A
G
K
G
S
S
Y
L
I
E
N
K
I
A
V
K
R
GIDRRNI
G
L
L
Y
D
E
L
Q
M
R
S
R
F
L
N
L
L
V
E
K
KIFN
Y
Y
D
V
W
D
Y
I
L
R
A
R
Q
MG
L
E
E
A
I
K
Y
V
SNI
34
HHSearch
63.03
22%
-96
- C3 -
2PT7
-
?
A:
[38-288]
-----------------------------------------------------------------------------------------------------------------------------
D
F
L
K
M
E
N
I
T
E
I
C
Y
N
G
-----
N
K
-------
V
V
W
V
L
K
N
N
G
E
W
Q
P
F
D
VRDRK
A
---
F
S
-
L
S
R
L
M
H
F
A
R
C
C
A
S
F
K
K
K
T
I
D
N
Y
------
E
N
P
---
I
L
S
S
N
L
----
A
N
G
E
R
V
-
Q
I
V
L
S
P
V
T
-
V
-
N
DE
T
I
S
I
S
I
R
I
P
S
K
------
T
T
Y
--
P
H
S
F
F
E
E
Q
---
G
F
Y
N
LLDN
K
E
Q
----------------------
A
I
S
A
-
I
K
D
G
I
A
I
G
K
N
V
I
V
C
G
G
T
G
S
G
K
T
T
Y
I
K
S
I
M
E
F
I
P
K
--
E
E
R
I
I
S
I
E
D
T
E
E
I
V
F
K
HHK
N
----
Y
-------
T
Q
L
F
F
G
--
G
N
---
I
T
---
S
A
D
C
L
K
S
C
L
R
M
R
P
D
R
I
I
L
G
E
L
R
S
S
E
-
A
Y
D
F
Y
N
V
L
C
S
G
H
K
G
T
L
T
T
L
H
A
G
S
S
E
E
A
F
I
R
L
A
------
N
M
-
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------