@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1494: (2016-03-26 )
MRKLVVGSRRSKLALTQSQQFINKLKAVEPNLEIEIKEIVTKGDRIVDKQLSKVGGKGLFVKEIQHELFEKNIDMAIHSLKDVPSVIPEGLTLGCIPDRELPFDAYISKTHTPLSQLPEGSIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLEKLQTEDYDAIILAAAGLRRMGWSDDIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDGSCQVPIAGYATISDQKEIEFTGLIMTPDGKERFEYTMNGTDPVELGKTVSNKLKEQGAYEIIKRLNEQH
Atome Classification :
(20 SA)
-........-.10........20..-----.....-------.30.----.......40...-...----..50.....---...60-----........70........80...-------.-....-------90..--......100...------....110--........120......----.130......----.-------.140.----..-....150.....-..-160.....--------..170.......---------180.-..-------------....190--........200.......210......-.220.......230........240.......250.......-------------260.......270.....--.-------------------------------...----280....-------------...290.......300......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MRKLVVGS-RRS
K
L
A
L
T
Q
S
Q
Q
F
I
N
-----
K
L
KAV-------EPN
L
----
E
I
E
I
K
E
I
VTKG
D
-
R
I
V
----
D
K
Q
L
S
KVGG---KGL
F
V
-----
K
E
I
Q
H
E
L
F
E
K
N
I
D
M
A
I
H
S
L
K
D
V
P
-------
S
-
V
I
PE-------G
L
T
L
--GCIPDREL
P
F
D
A
------
Y
ISKTH---T
P
L
S
QLPEG
S
I
I
G
T
S
S
L
----
R
R
-
G
A
Q
I
L
S
K----Y-------PN
L
E
I
----
K
W
-
I
RGN
I
D
T
R
L
E
K
L-QT-EDYD
A
I
I
L
--------
A
A
A
G
L
RRMGW
S
D
---------
D
I
V
T
-
S
Y
-------------LDRD
T
L
---
L
P
AIGQG
A
L
G
I
E
CRS
D
D
E
E
L
L
T
L
L
S
K
V
-
H
N
D
E
V
A
K
C
V
T
A
E
R
-
T
F
L
A
EMDGSCQVPIA
G
Y
A
TISDQK
E
I
E
F
-------------
T
G
L
I
MTPDGK
E
--
R
F
E
Y
T--M-------------------------------NGT----
D
P
V
E
L
G
K
-------------
T
V
S
N
K
L
K
EQ
G
A
Y
E
I
I
K
R
LNEQH
1
PsiBlast_PDB
99.87
59%
-90
- C4 -
4MLQ
2
?
A:
[3-309]
-
M
R
K
I
I
V
G
S
-
R
R
S
K
L
A
L
T
Q
T
K
W
V
I
E
-----
Q
L
K
K
Q
-------
G
L
P
F
----
E
F
E
I
K
E
M
V
----------------------------------
K
E
I
E
Q
A
M
L
D
K
E
I
D
M
A
V
H
S
M
K
D
M
P
-------
A
-
V
L
P
E
-------
G
L
T
I
--
G
C
I
P
L
R
E
D
H
R
D
A
------
L
I
S
K
N
G
---
E
R
F
E
E
L
P
S
G
A
V
I
G
T
S
S
L
----
R
R
-
G
A
Q
L
L
S
M
----
R
-------
S
D
I
E
I
----
K
W
-
I
R
G
N
I
D
T
R
L
E
K
L
-
K
N
-
E
D
Y
D
A
I
I
L
--------
A
A
A
G
L
S
R
M
G
W
S
K
---------
D
T
V
T
-
Q
Y
-------------
L
E
P
E
I
S
---
V
P
A
V
G
Q
G
A
L
A
I
E
C
R
E
N
D
H
E
L
L
S
L
L
Q
A
L
-
N
H
D
E
T
A
R
A
V
R
A
E
R
-
V
F
L
K
E
M
E
G
G
C
Q
V
P
I
A
G
Y
G
R
I
L
D
G
G
N
I
E
L
-------------
T
S
L
V
A
S
P
D
G
K
T
--
I
Y
K
E
H
--
I
-------------------------------
T
G
K
----
D
P
I
A
I
G
S
-------------
E
A
A
E
R
L
T
S
Q
G
A
K
L
L
I
D
R
V
K
E
E
-
2
PsiBlast_PDB
99.86
59%
-90
- C4 -
4MLV
2
?
A:
[3-309]
-
M
R
K
I
I
V
G
S
-
R
R
S
K
L
A
L
T
Q
T
K
W
V
I
E
-----
Q
L
K
K
Q
-------
G
L
P
F
----
E
F
E
I
K
E
M
V
----------------------------------
K
E
I
E
Q
A
M
L
D
K
E
I
D
M
A
V
H
S
M
K
D
M
P
-------
A
-
V
L
P
E
-------
G
L
T
I
--
G
C
I
P
L
R
E
D
H
R
D
A
------
L
I
S
K
N
G
---
E
R
F
E
E
L
P
S
G
A
V
I
G
T
S
S
L
----
R
R
-
G
A
Q
L
L
S
M
----
R
-------
S
D
I
E
I
----
K
W
-
I
R
G
N
I
D
T
R
L
E
K
L
-
K
N
-
E
D
Y
D
A
I
I
L
--------
A
A
A
G
L
S
R
M
G
W
S
K
---------
D
T
V
T
-
Q
Y
-------------
L
E
P
E
I
S
---
V
P
A
V
G
Q
G
A
L
A
I
E
C
R
E
N
D
H
E
L
L
S
L
L
Q
A
L
-
N
H
D
E
T
A
R
A
V
R
A
E
R
-
V
F
L
K
E
M
E
G
G
C
Q
V
P
I
A
G
Y
G
R
I
L
D
G
G
N
I
E
L
-------------
T
S
L
V
A
S
P
D
G
K
T
--
I
Y
K
E
H
--
I
-------------------------------
T
G
K
----
D
P
I
A
I
G
S
-------------
E
A
A
E
R
L
T
S
Q
G
A
K
L
L
I
D
R
V
K
E
E
-
21
HHSearch
92.65
42%
-88
- C4 -
3ECR
1
HEM3_HUMAN
A:
[21-359]
-
M
R
V
I
R
V
G
T
-
R
K
S
Q
L
A
R
I
Q
T
D
S
V
V
A
-----
T
L
K
A
S
-------
Y
P
G
L
----
Q
F
E
I
I
A
M
---------------------------
L
F
T
-----
K
E
L
E
H
A
L
E
K
N
E
V
D
L
V
V
H
S
L
K
D
L
P
-------
T
-
V
L
P
P
-------
G
F
T
I
--
G
A
I
C
K
R
E
N
P
H
D
A
------
V
V
F
H
P
K
FVG
K
T
L
E
T
L
P
E
K
S
V
V
G
T
S
S
L
----
R
R
-
A
A
Q
L
Q
R
K
----
F
-------
P
H
L
E
F
----
R
S
-
I
R
G
N
L
N
T
R
L
R
K
L
-
D
E
Q
Q
E
F
S
A
I
I
L
--------
A
T
A
G
L
Q
R
M
G
W
H
N
---------
R
V
-
G
-
Q
I
-------------
L
H
P
E
E
C
---
M
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
L
-
H
D
P
E
T
L
L
R
C
I
A
E
R
-
A
F
L
R
H
L
E
--
C
S
V
P
V
A
V
H
T
A
M
K
D
-
G
Q
L
Y
L
-------------
T
G
G
V
W
S
L
D
G
S
D
--
S
I
Q
E
T
--
M
Q
A
T
I
H
VPAQHEDGPEDDPQLVGITARNIP
R
G
P
Q
L
----
A
A
Q
N
L
G
I
-------------
S
L
A
N
L
L
L
S
K
G
A
K
N
I
L
D
V
A
R
Q
--
3
PsiBlast_PDB
89.66
46%
-75
- C4 -
1PDA
2
HEM3_ECOLI
A:
[6-303]
----
L
R
I
A
T
-
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
-----
K
L
M
A
S
-------
H
P
G
L
----
V
V
E
L
V
P
M
V
T
R
G
D
-
V
I
-------------
G
---
K
G
L
F
V
-----
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
K
D
V
P
-------
V
-
E
F
P
Q
-------
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
------
F
V
S
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
L
I
I
----
R
S
-
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--------
A
V
A
G
L
K
R
L
G
L
E
S
---------
R
I
-
R
-
A
A
-------------
L
P
P
E
I
S
---
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
-
N
H
H
E
T
A
L
R
V
T
A
E
R
-
A
M
N
T
R
L
E
G
A
C
Q
V
P
I
G
S
Y
A
E
L
I
D
-
G
E
I
W
L
-------------
R
G
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
R
R
--
G
-------------------------------
A
P
Q
----
D
A
E
Q
M
G
I
-------------
S
L
A
E
E
L
L
N
N
G
A
R
E
I
L
-------
20
HHSearch
89.00
45%
-79
- C4 -
1GTK
1
HEM3_ECOLI
A:
[3-309]
-
D
N
V
L
R
I
A
T
-
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
-----
K
L
M
A
S
-------
H
P
G
L
----
V
V
E
L
V
P
M
V
-------------------------
G
L
F
V
-----
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
K
D
V
P
-------
V
-
E
F
P
Q
-------
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
------
F
V
S
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
L
I
I
----
R
S
-
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--------
A
V
A
G
L
K
R
L
G
L
E
S
---------
R
I
-
R
-
A
A
-------------
L
P
P
E
I
S
---
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
-
N
H
H
E
T
A
L
R
V
T
A
E
R
-
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
I
D
-
G
E
I
W
L
-------------
R
A
L
V
G
A
P
D
G
S
Q
--
I
I
R
G
E
R
R
G
-------------------------------
A
P
Q
----
D
A
E
Q
M
G
I
-------------
S
L
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
Y
N
G
-
7
PsiBlast_PDB
88.72
46%
-77
- C4 -
1AH5
1
HEM3_ECOLI
A:
[6-303]
----
L
R
I
A
T
-
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
-----
K
L
M
A
S
-------
H
P
G
L
----
V
V
E
L
V
P
M
V
T
R
G
D
--------------------
K
G
L
F
V
-----
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
K
D
V
P
-------
V
-
E
F
P
Q
-------
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
------
F
V
S
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
L
I
I
----
R
S
-
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--------
A
V
A
G
L
K
R
L
G
L
E
S
---------
R
I
-
R
-
A
A
-------------
L
P
P
E
I
S
---
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
-
N
H
H
E
T
A
L
R
V
T
A
E
R
-
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
I
D
-
G
E
I
W
L
-------------
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
R
R
--
G
-------------------------------
A
P
Q
----
D
A
E
Q
M
G
I
-------------
S
L
A
E
E
L
L
N
N
G
A
R
E
I
L
-------
6
PsiBlast_PDB
88.47
45%
-76
- C4 -
1YPN
1
HEM3_ECOLI
A:
[6-303]
----
L
R
I
A
T
-
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
-----
K
L
M
A
S
-------
H
P
G
L
----
V
V
E
L
V
P
M
V
T
R
G
D
-
V
--------------
G
---
Q
G
L
F
V
-----
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
K
D
V
P
-------
V
-
E
F
P
Q
-------
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
------
F
V
S
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
L
I
I
----
R
S
-
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--------
A
V
A
G
L
K
R
L
G
L
E
S
---------
R
I
-
R
-
A
A
-------------
L
P
P
E
I
S
---
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
-
N
H
H
E
T
A
L
R
V
T
A
E
R
-
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
I
D
-
G
E
I
W
L
-------------
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
R
R
--
G
-------------------------------
A
P
Q
----
D
A
E
Q
M
G
I
-------------
S
L
A
E
E
L
L
N
N
G
A
R
E
I
L
-------
4
PsiBlast_PDB
87.57
46%
-80
- C4 -
2YPN
1
HEM3_ECOLI
A:
[6-303]
----
L
R
I
A
T
-
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
-----
K
L
M
A
S
-------
H
P
G
L
----
V
V
E
L
V
P
M
V
-------------------------
G
L
F
V
-----
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
K
D
V
P
-------
V
-
E
F
P
Q
-------
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
------
F
V
S
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
L
I
I
----
R
S
-
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--------
A
V
A
G
L
K
R
L
G
L
E
S
---------
R
I
-
R
-
A
A
-------------
L
P
P
E
I
S
---
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
-
N
H
H
E
T
A
L
R
V
T
A
E
R
-
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
I
D
-
G
E
I
W
L
-------------
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
R
R
--
G
-------------------------------
A
P
Q
----
D
A
E
Q
M
G
I
-------------
S
L
A
E
E
L
L
N
N
G
A
R
E
I
L
-------
5
PsiBlast_PDB
87.56
46%
-80
- C4 -
1GTK
1
HEM3_ECOLI
A:
[6-303]
----
L
R
I
A
T
-
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
-----
K
L
M
A
S
-------
H
P
G
L
----
V
V
E
L
V
P
M
V
-------------------------
G
L
F
V
-----
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
K
D
V
P
-------
V
-
E
F
P
Q
-------
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
------
F
V
S
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
L
I
I
----
R
S
-
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--------
A
V
A
G
L
K
R
L
G
L
E
S
---------
R
I
-
R
-
A
A
-------------
L
P
P
E
I
S
---
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
-
N
H
H
E
T
A
L
R
V
T
A
E
R
-
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
I
D
-
G
E
I
W
L
-------------
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
R
R
--
G
-------------------------------
A
P
Q
----
D
A
E
Q
M
G
I
-------------
S
L
A
E
E
L
L
N
N
G
A
R
E
I
L
-------
8
PsiBlast_PDB
86.72
43%
-71
- C4 -
4HTG
2
HEM3_ARATH
A:
[15-309]
------
I
G
T
-
R
G
S
P
L
A
L
A
Q
A
Y
E
T
R
E
-----
K
L
K
K
K
-------
H
P
E
L
VEDG
A
I
H
I
E
I
I
K
T
T
G
D
-
K
I
L
----
S
Q
P
L
A
D
I
G
G
---
K
G
L
F
T
-----
K
E
I
D
E
A
L
I
N
G
H
I
D
I
A
V
H
S
M
K
D
V
P
-------
T
-
Y
L
P
E
-------
K
T
I
L
--
P
C
N
L
P
R
E
D
V
R
D
A
------
F
I
C
L
T
A
---
A
T
L
A
E
L
P
A
G
S
V
V
G
T
A
S
L
----
R
R
-
K
S
Q
I
L
H
K
----
Y
-------
P
A
L
H
V
----
E
E
N
F
R
G
N
V
Q
T
R
L
S
K
L
-
Q
G
-
G
K
V
Q
A
T
L
L
--------
A
L
A
G
L
K
R
L
S
M
T
E
---------
N
-
V
A
-
S
I
-------------
L
S
L
D
E
M
---
L
P
A
V
A
Q
G
A
I
G
I
A
C
R
T
D
D
D
K
M
A
T
Y
L
A
S
L
-
N
H
E
E
T
R
L
A
I
S
C
E
R
-
A
F
L
E
T
L
D
G
S
C
R
T
P
I
A
G
Y
A
S
K
D
E
E
G
N
C
I
F
-------------
R
G
L
V
A
S
P
D
G
T
K
--
V
L
E
T
S
--
R
-------------------------------
K
G
P
YV
Y
E
D
M
V
K
M
G
K
-------------
D
A
G
Q
E
L
----------------
10
PsiBlast_PDB
83.92
43%
-88
- C4 -
3EQ1
4
HEM3_HUMAN
A:
[19-303]
--
R
V
I
R
V
G
T
-
R
K
S
Q
L
A
R
I
Q
T
D
S
V
V
A
-----
T
L
K
A
S
-------
Y
P
G
L
----
Q
F
E
I
I
A
-----------------------------
F
T
-----
K
E
L
E
H
A
L
E
K
N
E
V
D
L
V
V
H
S
L
K
D
L
P
-------
T
-
V
L
P
P
-------
G
F
T
I
--
G
A
I
C
K
R
E
N
P
H
D
A
V
V
F
H
PK
F
V
G
K
T
------
L
E
T
L
P
E
K
S
V
V
G
T
S
S
L
----
R
R
-
A
A
Q
L
Q
R
K
----
F
-------
P
H
L
E
F
----
R
S
-
I
Q
G
N
L
N
T
R
L
R
K
L
D
E
Q
-
Q
E
F
S
A
I
I
L
--------
A
T
A
G
L
Q
R
M
G
W
H
N
---------
R
-
V
G
-
Q
I
-------------
L
H
P
E
E
C
---
M
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
L
-
H
D
P
E
T
L
L
R
C
I
A
E
R
-
A
F
L
R
H
L
E
G
G
C
S
V
P
V
A
V
H
T
A
M
K
D
-
G
Q
L
Y
L
-------------
T
G
G
V
W
S
L
D
G
S
D
--
S
I
Q
E
T
--
M
-------------------------------
Q
A
T
----------------------------------------------
15
PsiBlast_CBE
83.64
43%
-88
- C4 -
3EQ1
5
HEM3_HUMAN
B:
[19-303]
--
R
V
I
R
V
G
T
-
R
K
S
Q
L
A
R
I
Q
T
D
S
V
V
A
-----
T
L
K
A
S
-------
Y
P
G
L
----
Q
F
E
I
I
A
-----------------------------
F
T
-----
K
E
L
E
H
A
L
E
K
N
E
V
D
L
V
V
H
S
L
K
D
L
P
-------
T
-
V
L
P
P
-------
G
F
T
I
--
G
A
I
C
K
R
E
N
P
H
D
A
VVFHPK
F
V
G
K
T
------
L
E
T
L
P
E
K
S
V
V
G
T
S
S
L
----
R
R
-
A
A
Q
L
Q
R
K
----
F
-------
P
H
L
E
F
----
R
S
-
I
Q
G
N
L
N
T
R
L
R
K
L
D
E
Q
-
Q
E
F
S
A
I
I
L
--------
A
T
A
G
L
Q
R
M
G
W
H
N
---------
R
-
V
G
-
Q
I
-------------
L
H
P
E
E
C
---
M
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
L
-
H
D
P
E
T
L
L
R
C
I
A
E
R
-
A
F
L
R
H
L
E
G
G
C
S
V
P
V
A
V
H
T
A
M
K
D
-
G
Q
L
Y
L
-------------
T
G
G
V
W
S
L
D
G
S
D
--
S
I
Q
E
T
--
M
-------------------------------
Q
A
T
----------------------------------------------
9
PsiBlast_PDB
82.41
43%
-87
- C4 -
3ECR
1
HEM3_HUMAN
A:
[21-301]
-
M
R
V
I
R
V
G
T
-
R
K
S
Q
L
A
R
I
Q
T
D
S
V
V
A
-----
T
L
K
A
S
-------
Y
P
G
L
----
Q
F
E
I
I
A
M
---------------------------
L
F
T
-----
K
E
L
E
H
A
L
E
K
N
E
V
D
L
V
V
H
S
L
K
D
L
P
-------
T
-
V
L
P
P
-------
G
F
T
I
--
G
A
I
C
K
R
E
N
P
H
D
A
V
V
F
H
PK
F
V
G
K
T
------
L
E
T
L
P
E
K
S
V
V
G
T
S
S
L
----
R
R
-
A
A
Q
L
Q
R
K
----
F
-------
P
H
L
E
F
----
R
S
-
I
R
G
N
L
N
T
R
L
R
K
L
D
E
Q
-
Q
E
F
S
A
I
I
L
--------
A
T
A
G
L
Q
R
M
G
W
H
N
---------
R
-
V
G
-
Q
I
-------------
L
H
P
E
E
C
---
M
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
L
-
H
D
P
E
T
L
L
R
C
I
A
E
R
-
A
F
L
R
H
L
E
--
C
S
V
P
V
A
V
H
T
A
M
K
D
-
G
Q
L
Y
L
-------------
T
G
G
V
W
S
L
D
G
S
D
--
S
I
Q
E
T
--
M
-------------------------------
Q
A
T
----------------------------------------------
14
PsiBlast_CBE
81.60
43%
-80
- C4 -
3ECR
1
HEM3_HUMAN
B:
[22-313]
--
R
V
I
R
V
G
T
-
R
K
S
Q
L
A
R
I
Q
T
D
S
V
V
A
-----
T
L
K
A
S
-------
Y
P
G
L
----
Q
F
E
I
I
A
M
------------------
K
I
G
E
---
K
S
L
F
T
-----
K
E
L
E
H
A
L
E
K
N
E
V
D
L
V
V
H
S
L
K
D
L
P
-------
T
-
V
L
P
P
-------
G
F
T
I
--
G
A
I
C
K
R
E
N
P
H
D
A
V
V
F
HPK
F
V
G
K
T
------
L
E
T
L
P
E
K
S
V
V
G
T
S
S
L
----
R
R
-
A
A
Q
L
Q
R
K
----
F
-------
P
H
L
E
F
----
R
S
-
I
R
G
N
L
N
T
R
L
R
K
L
D
E
Q
-
Q
E
F
S
A
I
I
L
--------
A
T
A
G
L
Q
R
M
G
W
H
N
---------
R
-
V
G
-
Q
I
-------------
L
H
P
E
E
C
---
M
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
L
-
H
D
P
E
T
L
L
R
C
I
A
E
R
-
A
F
L
R
H
L
E
--
C
S
V
P
V
A
V
H
T
A
M
K
D
-
G
Q
L
Y
L
-------------
T
G
G
V
W
S
L
D
G
S
D
--
S
I
Q
E
T
--
M
-------------------------------
Q
A
T
----------------------------------------------
40
Fugue
74.70
48%
-73
- C4 -
1PDA
2
?
?:
[3-219]
-
D
N
V
L
R
I
A
T
-
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
-----
K
L
M
A
S
-------
H
P
G
L
----
V
V
E
L
V
P
M
V
T
R
G
D
-
V
-------------
I
G
---
K
G
L
F
V
-----
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
K
D
V
P
-------
V
-
E
F
P
Q
-------
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
------
F
V
S
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
L
I
I
----
R
S
-
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--------
A
V
A
G
L
K
R
L
G
L
E
S
---------
R
I
-
R
-
A
A
-------------
L
P
P
E
I
S
---
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
43.72
17%
-22
- C2 -
1ZEL
11
?
A:
[2-297]
A
M
V
V
S
P
A
G
A
-
D
R
R
I
P
--
T
W
A
S
R
V
V
S
-----
G
L
A
R
D
-------
R
P
V
-----------
V
V
T
K
E
D
---
L
----
T
Q
R
L
T
E
A
G
C
GRD
P
D
S
A
I
-----
R
E
L
R
R
I
G
W
L
V
Q
L
-----
P
V
K
G
T
W
-------
A
-
F
I
P
P
-------
G
E
A
----
A
I
S
D
P
Y
L
P
L
R
S
------
W
L
A
R
D
Q
---
N
A
------
G
F
M
L
A
G
A
S
A
----
A
W
-
H
L
G
Y
L
D
R
----
Q
-------
P
D
G
R
I
----
P
I
-
W
L
P
P
A
K
R
L
P
D
G
L
-
A
S
Y
V
S
V
V
R
I
P
W
--------
N
A
A
D
T
A
L
L
A
P
R
P
---------
A
L
L
V
R
R
R
-------------
L
D
L
V
A
W
ATG
L
P
A
L
G
P
E
A
L
L
V
Q
I
A
T
R
P
A
S
F
G
P
W
A
D
L
V
P
H
L
D
D
L
V
A
D
C
S
D
E
R
L
E
R
L
L
S
G
R
P
T
S
A
W
Q
R
A
S
Y
L
L
D
S
G
G
E
P
A
R
G
-------------
Q
A
L
L
A
K
R
H
T
E
V
--
M
P
V
T
R
--
F
-------------------------------
T
T
A
----
H
S
G
E
S
V
W
-------------
A
P
E
Y
Q
L
V
D
E
L
V
V
P
L
L
R
V
I
G
K
--
44
Fugue
41.79
19%
-40
* C5 *
4XD1
14
?
A:
[21-417]
-
M
K
L
I
I
A
G
---
K
N
N
I
A
V
D
V
T
K
W
I
I
K
T
ISD
I
E
L
Y
S
V
C
N
ENDHG
N
D
S
F
----
Q
L
S
F
K
K
F
C
I
Q
F
N
I
P
I
I
----
S
L
E
D
A
Y
H
L
E
---
D
A
I
F
L
S
L
EFD
K
I
I
H
P
S
K
F
T
H
N
R
I
F
N
I
H
-
F
S
Y
L
P
AYKGMYT
S
-
A
W
P
I
L
N
NEQ
E
S
G
V
T
L
--
H
K
I
-
D
H
G
I
D
T
G
A
------
I
I
D
Q
Q
K
---
F
P
L
D
I
E
E
T
A
K
T
L
Y
L
K
Y
I
----
K
I
-
G
T
E
I
V
I
K
N
---
L
-------
P
A
L
I
S
GN
Y
S
I
V
-
E
Q
S
A
I
K
S
S
Y
Y
S
K
-
K
S
-
I
D
Y
K
N
L
M
I
DLNKT
A
H
E
I
L
Q
Q
I
R
A
F
T
F
R
D
YQLPRIDD
I
D
I
F
H
-
G
E
I
L
SSKSLSKPGTI
L
E
K
N
N
Y
---
H
L
I
L
S
T
I
D
Y
D
I
K
L
Y
S
D
N
F
D
E
I
L
T
A
C
E
D
-
K
S
P
E
F
I
S
K
L
L
K
T
E
-
N
I
L
F
E
K
N
H
L
G
A
S
P
I
I
I
A
A
Y
H
G
N
M
D
V
I
E
W
L
V
S
K
GVNINDRNY
K
G
T
T
V
A
M
Y
F
K
D
--
Y
M
L
R
S
--
G
-------------------------------
N
Y
T
----
G
L
E
N
L
I
N
L
GLDLFLKDNEGL
S
V
F
D
Y
M
R
K
N
K
N
I
E
L
F
N
F
M
S
T
F
N
31
HHSearch
37.03
12%
-43
- C4 -
3UIF
2
?
A:
[61-173]
-----------------------------------------------------------------------------------------------
N
E
G
F
A
S
G
K
I
D
F
G
I
Y
G
D
L
P
P
I
I
------
L
N
A
S
K
P
-------
T
V
Q
L
--
V
A
P
W
G
T
-
T
S
N
S
Y
------
L
V
V
P
K
N
STA
K
S
I
K
D
L
-
K
G
K
K
I
A
L
H
R
G
RPW
E
L
A
-
F
S
N
L
L
Q
S
E
GLT
F
-------
K
D
F
K
I
----
V
N
-
V
--
N
P
Q
V
G
A
A
A
L
-
A
S
-
G
T
V
D
G
F
F
S
--------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
36.61
12%
-33
* C4 *
2X26
1
SSUA_ECOLI
A:
[3-161]
--
E
A
L
R
I
G
Y
-
Q
K
G
S
I
G
M
V
L
A
K
S
-
H
Q
-----
L
L
E
K
R
-------
Y
P
E
S
----
K
I
S
W
V
E
F
P
A
-
G
P
-------------------------------
Q
M
L
E
A
L
N
V
G
S
I
D
L
G
S
T
G
D
I
P
P
I
-------
F
-
A
Q
A
A
-------
G
A
D
L
VY
V
G
V
E
P
P
K
P
K
A
E
V
------
I
L
V
A
E
N
SPI
K
T
V
A
D
L
-
K
G
H
K
V
A
F
Q
K
G
----
S
S
S
H
N
L
L
L
R
A
----
L
R
Q
A
GLKF
T
D
I
Q
P
-------
T
Y
L
T
P
A
D
A
R
A
A
F
-
Q
Q
-
G
N
V
D
A
W
A
I
--------
W
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
36.31
9%
-43
- C4 -
2VD3
12
HIS1_METTH
A:
[3-162]
--
P
K
I
R
I
A
V
P
S
K
G
R
I
S
E
---
P
-
A
I
R
-----
L
L
E
N
A
---------
G
V
----
G
L
K
D
--
T
V
N
R
K
L
-
F
S
K
T
QHP
Q
I
E
V
M
F
S
R
-------
A
------
A
D
I
P
E
F
V
A
D
G
A
A
D
L
G
I
T
G
Y
D
L
I
V
-------
E
--
R
G
S
-------
D
V
E
I
--
L
E
D
L
K
Y
G
R
A
S
L
V
------
L
A
A
P
E
D
STI
R
G
P
E
D
I
P
R
G
A
V
I
A
T
E
F
P
----
G
I
----
T
E
N
Y
----
L
R
E
-----
H
G
I
D
A
----
E
V
-
V
E
L
T
G
-
S
T
E
I
A
P
-
F
I
-
G
V
A
D
L
I
T
D
--------
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------