@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1719: (2016-03-28 )
MKRTLVLLITAIFILAACGNHKDDQAGKDNQKHNNSSNQVKEIATDKNVQGDNYRTLLPFKESQARGLLQDNMANSYNGGDFEDGLLNLSKEVFPTDKYLYQDGQFLDKKTINAYLNPKYTKREIDKMSEKDKKDKKANENLGLNPSHEGETNPEKIAEKSPAYLSNILEQDFYGGGDTKGKNIKGMTIGLAMNSVYYYKKEKDGPTFSKKLDDSEVKKQGKQMASEILSRLRENDDLKDIPIHFAIYKQSSEDSITPGEFITQATAEKSQTKLNEWHNINEKSALLPSSTAADYDENLNNNFKQFNDNLQSYFSNFTQAVGKVKFVDKKPQRLVVDLPIDYYGQAETIGITQYVTEQANKYFDKIDNYEIRIKDGNQPRALISKTKDDKEPQVHIYSN
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------.........10........20........30....-.....40.....-...50....-------....---60-----------.......-.70-..-...--...80-------........90.....-...100.......110-.........120.-.-----...-..-130.......140--.----------------...---...150........---.160-------------......-...170.....--....180..-....-..190-------------...-.-...--------.-------------------------------.200.......------------------210....-.---------..220--........230..----------.--------....240----....-----...250.......260.......270....---...280.......290....-.-...--.300--------.........310...-.--...320..-----.....330.......340.......350......-.360......-.370--...--.---...--.-.380---...-....390-----........-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------MK
R
T
L
V
L
L
I
T
A
I
F
I
L
A
ACGNHKDDQAGKDN-QKHN-NS
S
N
Q
V
K
E
I
ATD-KNVQGDN
Y
R
-------
T
LLP---FK-----------
E
S
Q
A
R
G
L
-
L
Q
D
-NM-ANS--YNGGD-------F
E
D
G
L
L
N
L
S
K
EVFPT-DKYLYQDGQFL
D
K
K
---
T
I
N
A
YLN
P
K
Y
T
K
R
-
E
-----
I
D
K
-
M
S
-
E
KDKKDKKANENL--G----------------LNP---SHEG--ET
N
P
E
K
I
A---EK---------------S
P
A
Y
L
S
-
N
I
L
E
--
Q
DFYG--GGDTK-GKN-I
K
G
M
-
T
I
G
---------------
L
A
M-N-
S
V
Y
--------
Y
-------------------------------
Y
K
KEKDGPTFS------------------KKL
D
D
S
E
-
V
---------
K
K
Q
G
---
K
Q
M
A
S
E
I
L
S
R
L
RE----------N--------DDLKDI
P
----
I
H
F
A
-----
I
Y
KQSSEDSIT
P
G
E
F
I
T
Q
A
TA
E
K
S
Q
T
K
L
N
E
---WHNIN
E
K
SALLPSS--TAAD-Y-DEN--LN----------
N
N
F
K
Q
F
N
D
N
L
Q
S
Y
F
S
-
N
--
F
T
Q
A
VGK
V
-----
K
F
VDKKP
Q
R
L
V
V
DLPIDYYGQAETI
G
I
T
Q
Y
V
T
E
Q
-
A
N
K
Y
F
D
KID
N
-
Y
E
----
I
R
I--K---DGN--Q-
P
R
A
L
---
I
SK-TKDDKE------P
Q
V
H
I
YSN-------
8
HHSearch
94.18
100%
-49
- C4 -
2QX2
5
?
A:
[13-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
L
Q
D
-
N
M
-
A
N
S
--
Y
N
G
G
D
-------
F
E
D
G
L
L
N
L
S
K
E
V
F
P
T
-
D
K
Y
L
Y
Q
D
G
Q
F
L
D
K
K
---
T
I
N
A
Y
L
N
P
K
Y
T
K
R
-
E
-----
I
D
K
-
M
S
-
E
K
D
K
K
D
K
K
A
N
E
N
L
--
G
----------------
L
N
P
---
S
H
E
G
--
E
T
N
P
E
K
I
A
---
E
K
---------------
S
P
A
Y
L
S
-
N
I
L
E
--
Q
D
F
Y
G
---------
K
N
-
I
K
G
M
-
T
I
G
---------------
L
A
M
-
N
-
S
V
Y
--------
Y
-------------------------------
Y
K
K
E
K
D
G
P
T
F
S
------------------
K
K
L
D
D
S
E
-
V
---------
K
K
Q
G
---
K
Q
M
A
S
E
I
L
S
R
L
R
E
----------
N
--------
D
D
L
K
D
I
P
----
I
H
F
A
-----
I
Y
K
Q
S
S
E
D
S
I
T
P
G
E
F
I
T
Q
A
T
A
E
K
S
Q
T
K
L
-
E
---
W
H
N
I
N
E
K
S
A
L
L
P
S
S
--
T
A
A
D
-
Y
-
D
E
N
--
L
N
----------
N
N
F
K
Q
F
N
D
N
L
Q
----------
Q
A
V
G
K
V
-----
K
F
V
D
K
K
P
Q
R
L
V
V
D
L
P
I
D
Y
Y
G
Q
A
E
T
I
G
I
T
Q
Y
V
T
E
Q
-
A
N
K
Y
F
D
K
I
D
N
-
Y
E
----
I
R
I
--
K
---
D
G
N
--
Q
-
P
R
A
L
---
I
S
K
-
T
K
D
D
K
E
------
P
Q
V
H
I
Y
S
N
-------
1
PsiBlast_PDB
93.78
98%
-49
- C4 -
2QX2
5
?
A:
[13-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
L
Q
D
-
N
M
-
A
N
S
--
Y
N
G
G
D
-------
F
E
D
G
L
L
N
L
S
K
E
V
F
P
T
-
D
K
Y
L
Y
Q
D
G
Q
F
L
D
K
K
---
T
I
N
A
Y
L
N
P
K
Y
T
K
R
-
E
-----
I
D
K
-
M
S
-
E
K
D
K
K
D
K
K
A
N
E
N
L
--
G
----------------
L
N
P
---
S
H
E
G
--
E
T
N
P
E
K
I
A
---
E
K
---------------
S
P
A
Y
L
S
-
N
I
L
E
--
Q
D
F
Y
G
---------
K
N
-
I
K
G
M
-
T
I
G
---------------
L
A
M
-
N
-
S
V
Y
--------
Y
-------------------------------
Y
K
K
E
K
D
G
P
T
F
S
------------------
K
K
L
D
D
S
E
-
V
---------
K
K
Q
G
---
K
Q
M
A
S
E
I
L
S
R
L
R
E
----------
N
--------
D
D
L
K
D
I
P
----
I
H
F
A
-----
I
Y
K
Q
S
S
E
D
S
I
T
P
G
E
F
I
T
Q
A
T
A
E
K
S
Q
T
K
L
-
E
---
W
H
N
I
N
E
K
S
A
L
L
P
S
S
--
T
A
A
D
-
Y
-
D
E
N
--
L
N
----------
N
N
F
K
Q
F
N
D
N
L
Q
----------
Q
A
V
G
K
V
-----
K
F
V
D
K
K
P
Q
R
L
V
V
D
L
P
I
D
Y
Y
G
Q
A
E
T
I
G
I
T
Q
Y
V
T
E
Q
-
A
N
K
Y
F
D
K
I
D
N
-
Y
E
----
I
R
I
--
K
---
D
G
N
--
Q
-
P
R
A
L
---
I
S
K
-
T
K
D
D
K
E
------
P
Q
V
H
I
Y
S
N
-------
23
Fugue
88.57
90%
-46
- C4 -
2QX2
5
?
A:
[13-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Q
-
D
N
M
A
N
S
--
Y
N
G
G
D
-------
F
E
D
G
L
L
N
L
S
K
E
V
F
P
T
-
D
K
Y
L
Y
Q
D
G
Q
F
L
D
K
K
---
T
I
N
A
Y
L
N
P
K
Y
T
K
R
-
E
-----
I
D
K
M
S
--
E
K
D
K
K
D
K
K
A
N
E
N
L
--
G
----------------
L
N
P
---
S
H
E
G
--
E
T
N
P
E
K
I
A
---
E
K
---------------
S
P
A
Y
L
S
-
N
I
L
E
--
Q
D
F
Y
G
--
K
N
I
---------
K
G
M
T
I
G
---------------
L
A
-
M
N
-
S
V
Y
--------
Y
-------------------------------
Y
K
K
E
K
D
G
P
T
F
S
------------------
K
K
L
D
D
S
E
-
V
---------
K
K
Q
G
---
K
Q
M
A
S
E
I
L
S
R
L
R
E
----------
N
--------
D
D
L
K
D
I
P
----
I
H
F
A
-----
I
Y
K
Q
S
S
E
D
S
I
T
P
G
E
F
I
T
Q
A
T
A
E
K
S
Q
T
K
L
E
----
W
H
N
I
N
E
K
S
A
L
L
P
S
-----------
S
T
--
A
A
----------
D
Y
D
E
N
L
N
N
N
F
K
Q
F
N
D
-
N
--
L
Q
Q
A
V
G
K
V
-----
K
F
V
D
K
K
P
Q
R
L
V
V
D
L
P
I
D
Y
Y
G
Q
A
E
T
I
G
I
T
Q
Y
V
T
E
Q
-
A
N
K
Y
F
D
K
I
D
N
-
Y
E
----
I
R
I
--
K
---
D
G
N
--
Q
-
P
R
A
L
---
I
S
K
-
T
K
D
D
K
E
------
P
Q
V
H
I
Y
S
N
-------
2
PsiBlast_PDB
75.86
35%
-38
- C4 -
4HN3
6
?
A:
[19-349]
-------------------------------------------------------------------------------------------------------------------------
I
M
T
K
-
N
Q
I
S
S
N
Y
Y
K
-------
T
V
L
P
---
Y
K
-----------
A
S
K
S
R
G
L
-
V
V
S
-
N
I
-
Y
S
R
--
Y
D
I
N
E
-------
L
E
S
G
L
M
R
V
S
Q
N
K
Y
S
P
-
D
N
Y
L
F
Q
E
G
Q
Y
L
D
K
E
---
T
L
E
K
W
L
D
----------------------
R
K
S
D
K
N
P
N
-----
G
----------------
L
N
P
---
A
S
N
G
--
N
G
E
N
R
K
-----------------------
P
I
Y
L
A
-
H
I
L
E
--
Q
D
Y
L
K
--
Q
T
D
K
D
-
T
V
A
-
L
G
G
I
-
S
I
A
---------------
L
A
M
-
N
-
S
V
D
--------
Y
-------------------------------
Y
Q
K
E
K
Y
G
D
T
Y
E
------------------
Q
P
I
S
D
S
E
-
L
---------
L
A
Q
G
---
K
E
M
S
A
T
V
L
N
R
I
R
Q
----------
T
--------
K
G
L
E
N
V
P
----
V
T
I
A
-----
I
Y
K
Q
G
A
R
D
A
V
A
P
G
N
Y
I
A
Y
A
T
A
N
G
D
S
--
L
S
N
---
W
K
D
I
D
E
K
N
Y
V
L
P
S
T
--
E
S
A
K
-
D
-
H
K
T
--
D
N
----------
D
N
F
L
N
F
K
K
A
I
E
D
Y
Y
P
-
N
--
F
T
G
V
V
G
R
G
-----
R
Y
E
D
G
Q
L
A
E
L
N
I
D
I
P
L
Q
F
Y
G
E
A
E
I
I
G
F
T
Q
Y
V
T
D
L
-
V
G
Q
H
I
P
K
T
A
D
-
L
Q
----
V
N
I
--
S
---
T
S
D
--
G
-
P
A
A
L
---
I
T
R
-
K
A
N
E
D
A
------
A
T
A
H
I
Y
---------
9
HHSearch
70.22
29%
-28
- C4 -
3IB5
6
?
A:
[7-346]
------------------------------------------------------------------------------------------------------------------------
G
Y
Q
T
T
-
G
E
N
N
S
S
D
Y
Q
-------
G
I
I
E
DGE
Y
K
-----------
T
S
K
S
R
G
V
-
G
I
S
-
Q
N
S
D
N
L
--
L
N
L
K
S
-------
F
E
A
G
L
T
T
I
S
K
D
H
F
S
T
-
K
S
Y
I
F
Q
E
G
Q
Y
L
N
K
A
---
T
I
Q
D
W
L
G
R
K
S
-------------------------
S
S
N
P
E
--
G
----------------
L
N
P
---
S
D
N
G
--
K
K
E
A
N
K
------
R
---------------
N
P
I
Y
V
Q
-
Q
I
E
E
--
Q
D
Y
M
K
--
Q
N
N
G
K
--
L
E
-
L
A
G
M
-
T
I
G
---------------
I
G
M
-
N
-
Q
K
D
--------
Y
-------------------------------
Y
Q
K
E
Q
Y
G
A
T
Y
S
------------------
T
T
I
S
K
E
K
-
R
---------
I
E
E
G
---
K
I
A
A
K
K
V
L
A
R
V
R
Q
----------
K
--------
V
-
G
N
N
V
P
----
I
V
I
A
-----
M
F
A
Q
A
P
N
D
S
L
V
G
G
Y
F
Y
S
Y
T
V
S
K
S
G
T
D
I
-
G
S
---
W
T
E
T
N
I
K
S
Y
V
L
P
A
T
--
E
D
N
K
-
L
P
N
D
N
--
D
S
----------
T
S
F
D
N
F
Q
K
E
V
K
N
F
F
P
-
N
--
I
S
N
V
T
G
Q
G
-----
Q
Y
K
D
K
T
L
Q
G
L
H
I
T
I
T
T
Q
F
Y
S
E
T
E
I
T
S
F
T
Q
Y
V
A
Q
A
-
A
K
S
Y
L
P
S
G
I
P
-
V
D
----
I
K
I
--
N
---
G
S
D
--
G
E
T
Q
S
F
---
V
S
T
-
T
G
G
N
G
G
------
Y
Y
T
H
V
F
G
--------
3
PsiBlast_PDB
69.69
29%
-30
- C4 -
3IB5
5
?
A:
[28-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
-----------
T
S
K
S
R
G
V
G
I
S
Q
-
N
S
-
D
N
L
--
L
N
L
K
S
-------
F
E
A
G
L
T
T
I
S
K
D
H
F
S
T
-
K
S
Y
I
F
Q
E
G
Q
Y
L
N
K
A
---
T
I
Q
D
W
L
G
--------------------------
R
K
S
S
S
N
P
E-
G
----------------
L
N
P
---
S
D
N
G
--
K
K
E
A
N
K
------
R
---------------
N
P
I
Y
V
Q
-
Q
I
E
E
--
Q
D
Y
M
K
--
Q
N
N
G
K
--
L
E
-
L
A
G
M
-
T
I
G
---------------
I
G
M
-
N
-
Q
K
D
--------
Y
-------------------------------
Y
Q
K
E
Q
Y
G
A
T
Y
S
------------------
T
T
I
S
K
E
K
-
R
---------
I
E
E
G
---
K
I
A
A
K
K
V
L
A
R
V
R
Q
----------
K
--------
V
G
-
N
N
V
P
----
I
V
I
A
-----
M
F
A
Q
A
P
N
D
S
L
V
G
G
Y
F
Y
S
-
Y
T
V
S
K
S
G
T
D
I
G
S
---
W
T
E
T
N
I
K
S
Y
V
L
P
A
T
--
E
D
N
K
-
L
P
N
D
N
--
D
S
----------
T
S
F
D
N
F
Q
K
E
V
K
N
F
F
P
-
N
--
I
S
N
V
T
G
Q
G
-----
Q
Y
K
D
K
T
L
Q
G
L
H
I
T
I
T
T
Q
F
Y
S
E
T
E
I
T
S
F
T
Q
Y
V
A
Q
A
-
A
K
S
Y
L
P
S
G
I
P
-
V
D
----
I
K
I
N
G
S
---
D
G
---
E
-
T
Q
S
F
---
V
S
T
-
T
G
G
N
G
G
------
Y
Y
T
H
V
F
---------
10
HHSearch
46.05
27%
28
- C4 -
3N2Q
-
?
A:
[56-340]
------------------------------------------------------------------------------------------------------------------------------------------------
A
P
---
L
K
-----------
E
Q
K
V
I
N
T
-
A
N
I
-
K
T
-
N
S
K
--
L
D
L
A
E
-------
Y
E
N
G
L
I
N
I
A
T
Q
Q
F
D
T
-
E
S
H
V
L
Q
L
N
Q
Y
I
P
E
K
---
L
I
D
E
L
V
A
K
V
E
-----------------------------------------------------------------------------------------
A
P
-
V
L
T
-
N
I
I
E
--
Q
D
Y
F
G
--
K
---
N
-
E
L
S
-
L
S
G
V
-
M
I
G
---------------
L
A
M
-
S
-
S
------------------------------------------------------------------------
S
V
S
N
E
E
-
A
---------
M
S
K
G
---
T
E
V
A
K
Q
L
I
E
A
I
N
K
----------
N
--------
D
K
Y
N
K
S
P
----
I
T
F
A
-----
I
F
K
Q
E
S
T
S
S
L
K
N
G
T
Y
I
A
S
A
T
V
Q
K
N
D
T
N
L
G
N
---
W
S
T
I
D
E
K
S
Y
S
Y
P
S
D
--
E
F
T
Q
-
A
-
H
G
E
--
D
N
----------
T
K
I
N
N
F
A
K
E
I
K
G
F
-
N
G
D
--
F
I
P
V
N
A
K
V
-----
S
Y
K
K
D
Q
M
D
T
L
N
M
N
I
V
I
K
Y
N
G
K
T
E
L
M
A
L
T
Q
L
A
A
Q
G
-
M
L
D
K
L
P
K
D
A
K
-
V
Q
----
L
Q
I
--
K
---
S
E
S
--
K
-
I
E
A
V
---
I
I
K
-
E
K
N
S
D
K
------
P
F
V
S
F
L
---------
4
PsiBlast_PDB
45.13
24%
27
- C4 -
3N2Q
-
?
A:
[57-337]
-------------------------------------------------------------------------------------------------------------------------------------------------
P
---
L
K
-----------
E
Q
K
V
I
N
T
-
A
N
I
-
K
T
-
N
S
K
--
L
D
L
A
E
-------
Y
E
N
G
L
I
N
I
A
T
Q
Q
F
D
T
-
E
S
H
V
L
Q
L
N
Q
Y
I
P
E
K
---
L
I
D
------------------------------------------------------------------------
E
L
V
A
---
K
V
---------------
E
A
P
V
L
T
-
N
I
I
E
--
Q
D
Y
F
G
--
K
---
N
-
E
L
S
-
L
S
G
V
-
M
I
G
---------------
L
A
M
-
S
-
S
------------------------------------------------------------------------
S
V
S
N
E
E
-
A
---------
M
S
K
G
---
T
E
V
A
K
Q
L
I
E
A
I
N
K
----------
N
--------
D
K
Y
N
K
S
P
----
I
T
F
A
-----
I
F
K
Q
E
S
T
S
S
L
K
N
G
T
Y
I
A
S
A
T
V
Q
K
N
D
T
N
L
G
N
---
W
S
T
I
D
E
K
S
Y
S
Y
P
S
D
E
F
T
Q
A
H
-
G
-
E
D
N
T
K
I
N
----------
N
F
A
K
E
I
K
G
-----
F
--
N
GD
F
I
P
V
N
A
K
V
-----
S
Y
K
K
D
Q
M
D
T
L
N
M
N
I
V
I
K
Y
N
G
K
T
E
L
M
A
L
T
Q
L
A
A
Q
G
-
M
L
D
K
L
P
K
D
A
K
-
V
Q
----
L
Q
I
--
K
---
S
E
S
--
K
-
I
E
A
V
---
I
I
K
-
E
K
N
S
D
K
------
P
F
V
------------
25
Fugue
40.66
17%
37
- C3 -
4OV8
9
?
A:
[6-472]
--------------------------------------------------DT
L
N
D
V
I
Q
D
P
T
R
R
N
K
L
I
N
D
N
NLL
K
G
I
I
M
G
R
D
G
P
V
P
S
S
R
E
L
I
V
-----
R
P
D
T
L
R
A
I
I
N
-
N
R
A
T
-
I
E
T
T
T
M
E
A
E
F
T
E
-
T
L
M
E
S
N
Y
N
S
-------
A
S
V
K
---
V
S
-----------
A
P
C
I
T
A
N
-
S
E
Y
-
S
E
-
S
S
S
--
F
K
N
T
E
-------
T
E
K
S
M
Y
T
S
S
R
Y
L
F
P
Q
-
G
R
I
D
F
T
T
P
D
S
G
D
V
I
---
K
L
S
P
Q
F
T
S
G
V
Q
A
A
L
A
-----
K
A
T
-
G
T
-
E
K
R
E
A
L
Q
N
L
F
Q
E
Y
--
G
CVFRT
K
V
H
I
G
G
V
L
S
A
H
T
M
E
---
T
F
S
R
--
S
E
N
E
T
E
V
K
---
Q
D
---------------
V
K
A
G
L
E
-
G
A
V
K
--
G
--
W
G
--
G
G
A
T
A
-
G
H
G
-
N
T
Q
G
-
T
I
T
---------------
T
S
Q
-
N
-
R
K
L
--------
N
-------------------------------
V
K
Y
I
V
N
G
G
D
Y
T
KIQN
T
E
E
W
V
A
S
T
NQSEHW
R
V
I
E
V
T
E
-
V
---------
T
A
V
A
---
D
L
L
P
Q
P
I
R
G
Q
V
K
D
----------
L
L
KP
L
L
G
K
W
V
D
V
E
K
V
P
GLES
L
P
V
S
-----
V
Y
R
P
--
K
G
A
I
P
A
G
W
F
W
L
G
D
T
A
D
A
S
K
A
L
L
V
K
P
TL
P
A
R
S
G
R
N
P
A
L
T
S
L
H
--
Q
G
S
G
-
M
-
T
E
Q
--
P
F
----------
V
D
L
P
Q
Y
Q
Y
-
L
S
T
Y
F
G
-
S
--
F
A
H
D
T
P
P
G
-----
S
T
L
--
R
G
L
R
P
D
H
V
L
P
G
R
Y
E
M
H
G
D
T
I
S
T
A
V
Y
V
T
R
P
-
V
D
V
P
F
P
E
D
E
A
-
F
D
LK
S
L
V
R
V
--
K
LPG
S
G
N
PP
K
-
P
R
S
A
---
L
-------
K
K
------
S
M
V
L
F
D
---------
31
Fugue
34.96
12%
31
- C3 -
2OCC
-
COX1_BOVIN
A:
[1-514]
--------MFINRWLFSTN
H
K
D
I
G
T
L
Y
L
L
F
G
A
W
A
G
M
V
G
T
A
L
S
L
L
I
R
A
E
L
GQPGTLLGD
D
Q
I
Y
N
V
V
V
T
A
H
A
F
V
M
I
FFM
V
M
P
I
M
I
G
G
F
G
N
W
L
V
P
L
M
I
G
A
P
D
M
A
F
P
R
M
N
N
-
M
S
F
W
-
L
L
P
P
S
F
L
L
L
L
A
S
-
S
M
V
E
-----AGAGTGW
T
V
Y
P
---
P
L
AGNLAHAGA
S
V
D
L
T
I
F
S
L
-
H
L
A
-
G
V
-
S
S
I
--
L
G
A
I
N
-------
F
I
T
T
I
I
N
M
K
----
P
P
-
A
M
S
Q
Y
Q
T
P
L
F
V
W
S
V
---
M
I
T
A
V
L
L
-
L
L
S
L
P
-
V
-----
L
A
A
-
G
I
-
T
M
L
L
T
D
R
N
L
N
T
T
F
---------------------
F
---
D
P
A
G
--
G
G
D
P
I
L
Y
Q
---
H
L
F
W
F
F
G
H
P
E
V
Y
I
L
I
L
P
G
F
G
M
I
S
-
H
I
V
T
-----
Y
Y
--
S
G
K
K
E
-
P
F
G
-
Y
M
G
M
-
V
W
A
---------------
M
M
S
-
I
-
G
F
L
G
F
I
V
WAHH
M
-------------------------------
F
T
V
G
M
D
V
D
T
R
A
------------------
Y
F
T
S
A
T
M
I
I
---------
A
I
P
T
---
G
V
K
V
F
S
W
L
A
T
L
H
G
----------
G
--------
N
I
K
W
S
P
A
----
M
M
W
A
L
G
F
I
F
L
F
T
V
G
G
L
T
G
I
V
L
A
N
S
S
L
D
I
V
L
H
D
T
Y
Y
V
V
A
H
---
F
H
Y
V
L
S
M
G
A
V
F
A
I
M
--
G
G
F
V
-
H
-
W
F
P
--
L
F
----------
S
G
Y
T
L
N
D
T
W
A
K
I
H
F
A
-
I
--
M
F
V
G
V
N
M
T
FFP
Q
H
F
L
G
L
S
G
M
P
R
R
Y
S
D
Y
P
D
A
Y
T
M
W
N
T
I
S
S
M
G
S
F
I
S
L
T
-
A
V
M
L
M
V
F
I
I
W
-
E
A
----
F
A
S
--
K
---
R
E
V
--
L
----
T
---
V
D
L
-
T
T
T
N
L
E
WLNGCP
P
P
Y
H
T
F
E
E
P
T
Y
V
N
LK
30
Fugue
33.52
15%
43
- C2 -
3MT1
1
?
A:
[2-365]
------------------------------------------------------------------------------------
I
E
T
P
Y
Y
L
I
D
-----------
K
A
K
-
L
T
R
N
M
E
R
I
A
H
V
R
E
K
S
G
A
-
K
A
L
L
A
------------
L
K
C
---
F
A
-----------
T
W
S
V
F
D
L
M
R
D
Y
M
D
G
-
T
T
S
--
S
S
L
F
E
-------
V
R
L
G
R
E
R
F
G
K
E
T
H
A
Y
S
V
A
Y
G
D
N
E
I
D
E
V
V
S
H
---
A
D
K
I
I
F
N
S
------------
I
S
Q
-
L
E
-
R
F
A
D
K
A
A
G
I
A
R
G
L
--
R
----------------
L
N
P
---
Q
R
L
G
--
E
W
D
V
P
K
V
E
---
R
V
M
--------------
D
R
I
N
G
F
M
I
H
N
N
--
N
K
------
D
F
G
L
-
F
D
R
M
L
G
E
I
-
E
E
R
---------------
F
G
A
-
L
I
A
R
V
--------
D
-------------------------------
W
V
S
L
G
G
G
I
H
F
T
------------------
G
D
D
Y
P
-----------------------
V
D
A
F
S
A
R
L
R
A
----------
F
--------
S
D
R
Y
G
V
Q
----
I
Y
L
E
----------------
P
G
E
A
S
I
T
K
S
T
T
L
E
V
T
V
L
D
T
---
L
Y
N
-
G
K
N
L
A
I
V
D
S
S
--
I
E
A
H
M
L
-
D
L
L
--
I
Y
----------
R
E
T
A
K
V
L
P
N
E
G
S
H
S
Y
M
I
--
C
G
K
S
C
L
A
G
-----
D
V
F
G
----
E
F
R
F
A
E
E
L
K
---
V
G
D
R
I
S
F
Q
D
A
A
G
Y
T
M
V
K
K
N
W
F
N
G
V
K
M
P
A
----
I
A
I
--
R
---
E
L
D
--
G
-
S
V
R
T
---
V
R
E
F
T
Y
A
D
Y
E
------
Q
S
L
S
-----------
6
PsiBlast_PDB
31.13
29%
106
- C4 -
3FBZ
7
Y140_AFV1Y
A:
[15-51]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
K
T
K
L
Y
L
---
W
R
N
L
---
G
G
L
I
P
E
D
--
M
A
I
S
-
V
-
T
E
S
--
I
T
----------
A
D
W
K
Q
Y
N
D
----------------------------------------------------------------------------------------------------------------------------------
29
Fugue
26.98
16%
61
- C1 -
4UN1
1
?
B:
[21-179]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
S
H
-
Q
F
S
P
E
E
Q
A
V
L
R
I
V
Q
A
N
----------------
L
P
D
---
S
L
T
P
--
Y
A
D
L
A
E
Q
A
---
G
M
---------------
T
E
A
Q
V
L
-
E
L
L
G
--
R
L
K
A
S
--
G
A
I
R
R
F
G
A
S
-
I
K
H
Q
-
K
T
G
---------------
W
T
H
-
N
-
A
M
V
--------
A
-------------------------------
W
K
------
V
T
P
------------------
D
Q
V
D
D
C
G
-
R
---------
K
A
A
E
---
H
S
H
I
S
H
V
Y
Y
R
P
S
S
----------
A
--------
P
D
W
P
Y
-
E
----
M
Y
T
M
-----
I
H
G
R
S
E
A
E
C
L
G
V
V
E
D
V
K
R
T
T
S
L
K
E
H
A
I
L
R
S
---
L
K
E
L
K
K
T
S
M
T
Y
F
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
26.69
23%
53
- C4 -
2B3W
-
RIBX_ECOLI
A:
[1-149]
------------------------------------------------------------------------------------------------------------------------------------------------
M
P
---
V
R
-----------
A
Q
R
I
Q
H
V
-
M
Q
D
-
T
I
-
I
N
F
--
Y
S
T
S
D
D
Y
G
D
F
SN
F
A
A
W
P
I
K
V
D
G
K
T
W
P
T
-
S
E
H
Y
F
Q
A
Q
K
F
L
D
E
K
Y
R
E
E
I
R
R
V
S
S
P
M
V
A
A
R
-
M
-----
G
R
D
-
R
S
-
K
P
L
R
K
N
W
E
S
V
K
E
Q
--
V
----------------
M
R
K
---
A
L
R
A
K
F
E
Q
H
A
E
L
R
A
L
L
L
A
T
---------------
A
P
A
K
L
V
-
E
H
T
E
--
N
D
A
Y
W
GD
G
G
H
G
K
-
G
K
N
-
R
L
G
Y
-
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
24.61
20%
101
* C3 *
1AIL
-
NS1_I72A2
A:
[1-70]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
S
N
-
T
V
S
S
F
Q
V
D
C
F
L
W
H
V
---
R
K
Q
V
V
D
Q
E
L
G
D
A
P
-
F
-----
L
D
R
-
L
R
-
R
D
Q
K
S
L
R
G
R
G
S
T
L
--
G
----------------
L
N
I
E
A
A
T
H
V
G
--
K
Q
I
V
E
K
I
L
---
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
22.27
18%
66
- C3 -
4OUA
8
?
B:
[4-557]
LLATVGPTGGVKNRLDIVDFVRDEKFFTLYIRALQAIQDKDQSDYSSFFQLSGIHGLPFTPWAKPKDTPTVPYESGY
C
T
H
S
Q
V
L
F
P
T
W
H
R
V
Y
V
S
I
Y
E
Q
I
L
Q
E
A
A
K
G
I
A
K
K
F
T
-
V
H
K
K
E
W
A
Q
A
A
E
D
L
R
Q
P
Y
W
D
T
G
F
-------
A
L
V
P
---
P
D
-----------
E
-----
I
-
I
K
L
-
E
Q
-
V
K
I
TN
Y
D
G
T
K
-------
I
T
V
R
N
P
I
L
R
Y
S
F
H
P
I
-
D
P
S
F
N
G
Y
P
N
F
D
T
W
K
---
T
--
T
V
R
N
P
D
A
D
K
K
-
E
NIPAL
I
G
K
-
L
D
L
E
A
D
S
T
R
E
K
T
Y
N
M
L
--
K
----------------
F
N
A
---
N
W
E
A
--
F
S
N
H
G
E
F
D
---
D
T
---------------
H
A
N
S
L
E
-
A
V
H
D
DI
H
G
F
V
G
--
R
G
A
I
R
-
G
H
M
-
T
H
A
L
-
F
A
A
FDPIFWLHHSNVDRH
L
S
L
-
W
-
Q
A
L
--------
Y
PGVWVTQGPEREGSMGFAPGTELNKDSALEP
F
Y
E
T
E
D
K
P
W
T
S
------------------
V
P
L
T
D
T
A
-
L
LNYSYPDFD
K
V
K
G
GTP
D
L
V
R
D
Y
I
N
D
H
I
D
R
RYGIKKSEGG
K
--------
N
P
A
Q
D
L
L
----
S
D
F
K
-----
G
V
T
H
D
H
N
E
D
L
K
M
F
D
W
T
I
Q
A
S
W
K
K
F
E
L
D
D
S
F
---
A
I
I
F
Y
F
A
A
D
G
S
T
N
V
--
T
K
E
N
-
Y
-
I
G
S
--
I
N
IFRGTTPTNC
A
N
C
R
T
Q
D
N
L
V
Q
E
G
F
V
-
H
--
L
D
R
F
I
A
R
D
LD---
T
F
D
P
Q
A
V
H
R
Y
L
K
E
K
K
L
S
Y
K
V
V
A
D
D
H
S
V
T
--------------
L
K
S
-
L
R
----
I
R
V
--
Q
-----
G
--
R
-
P
L
H
L
PPG
V
S
F
-
P
R
L
D
K
N
------
I
P
I
V
N
F
D
D
VLDLVTG
7
PsiBlast_PDB
22.05
27%
82
- C4 -
4XDS
3
DGTP_ECOLI
A:
[36-99]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
G
R
I
-
I
N
S
P
-
A
I
R
---------------
R
L
Q
-
Q
-
K
T
Q
--------
V
-------------------------------
F
P
L
E
--
A
A
V
R
T
------------------
R
L
T
H
S
M
E
-
V
---------
Q
Q
V
G
---
R
Y
I
A
K
E
I
L
S
R
L
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
20.48
27%
229
* C4 *
1LBJ
-
A:
[1-22]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
P
I
F
T
Y
G
-
E
-----
L
Q
R
-
M
Q
-
E
K
E
R
N
K
G
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
16.37
18%
203
- C4 -
2KET
-
A:
[2-23]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
K
R
F
R
K
K
F
K
K
L
F
K
-
K
--
L
S
P
V
I
P
L
----------------------------------------------------------------------------------------------------------------
15
HHSearch
12.12
7%
176
- C4 -
3OMB
-
?
A:
[361-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
N
K
D
--
A
A
----------
L
K
L
A
N
L
L
Y
S
E
K
Y
S
V
Q
-
Q
--
F
L
G
S
F
G
-----------------------------------------------------------------------------------------------------------------