@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1828: (2016-03-29 )
METGKSDVLDKIEKINKKDSALQEIIPKGYEIEHHQCGVALYQLIPSKKEGEPDKKVFITNTIPQITERFEDIESNEVSFNMLFYDNKTPVNIAVSAEEISDSRQLLKLVNKKLDVTSSTSTKLVDYINVSKRYNPPLNVKVATRLGHVKGYFIYPYQEVMKDSNVKLFSNDKGFQKLIDSFRSKGTLQGYSKKVFAQIKDLPMVMVMLYASLGSVLLREFGLQPFIVEISGSTSTGKTFTLNLVSSVWGTSDLITTWSSTQNSIESMASFLNSFPMFKDDTRNTHPKFVTSTTYNFSSGESKSRSNINLTLNAKKEWRNILISTGESSIANMADEKAGVSARVVTLQDPPYPDNFDFTTLDKSFRENYGTLGLAFIKQYESKKDVYKNAFESYQRYFNQKGSNEIMQRLGRAFALLQVTGEVLNDIDGFEHDHFKIIEQAYDSMVKNNKTIDKPKQLLEELLQYLDANRNNIVGDGYDSVNYGDVKAVYKHDFLCIKNETVKNKLGHEMQTITGQWDKKGYLIKDKKRIQKQVKHKSQRHLGYAIKKEIIEELGFDFSISHNPYTESY
Atome Classification :
(20 SA)
---------------------------------------------.....-------....10........20........-------30..-....-----------------..40........50...-.....---60-------........----.70......-..80.........90---------........100------------...-----......110.----------------------......120.......130.....----..140.......--------150-----..--------......160-----.-------.-.....170.......-----180...--....190--..--------..---....200....-..-----.210..--...---..-220......------...230.......240.------......250--------------.-------.....-.-260---.---.....------..-.--270.---..-------...-.280.......290------------....---------.....300..-.....310.......320...--..--.----.330.......340--------------....-------....350---------------..-.......360-------........370--------..-..----------....380----------.......------390---------........400---..-.....410...----....420.......-----430.......440.......-------------..450.......460.--...------...-470...---.....---480------------....--------....490--........---500....---...510.....-----..520..------.....530-....------.-..---540.......550..--------.-....----------------------560......--..---------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------MET
G
K
-------
S
D
V
L
D
K
I
E
K
IN
K
K
D
S
A
L
Q
E
IIPKG-------
Y
E
I
E
-
H
H
Q
C
-----------------
G
V
A
L
Y
Q
LIPSKKEGEPD-
K
K
V
F
I
---T--------NT
I
P
Q
I
T
E
----
R
F
E
DIESNE-
V
S
F
-
N
M
L
F
YDNKT
P
V
---------
N
I
A
V
S
A
E
E
I--------------S
D
S
-----
R
Q
L
L
K
L
V
N
K
K----------------------LDVTSSTS
T
K
L
V
D
Y
I
NVSKRYNPP----L
N
V
K
V
A
T
RLGHV--------
K
G
------
Y
F
--------IY
P
Y
Q
E
V
MK-----D-------S-N
V
K
L
FSN
D
K
G
F
Q
K
L
I
-----
D
S
F
R
SK--GTL
Q
G
Y
---
S
K
--------
K
V
---
F
A
Q
I
KD
L
P
M
V
M
-
V
M
-----
L
Y
A
S
L
G
--
S
V
L
---
L
R
-
E
--FGLQ
P
F
------
I
V
E
ISGSTSTG
K
T
F
T
L
N
------
L
V
S
S
VWGTS--------------
D
-------
L
I
T
TW-
S
-
S
-----
T
---
Q
N
S
I
E
------
S
M
-
A
--
S
F
L
N
---SF-------PMF-KDDTRNTHP
K
F
V
--------------
T
S
T
T
---------
Y
NFSSGESKS-RS
N
I
N
L
T
L
NA
K
K
E
W
R
N
I
L
IST--GE--
S
----
S
I
A
N
M
A
D
EKAG
V
S
---------------
A
R
V
V
-------
T
L
QDP-----------------PY-PDNFD
F
T
T
L
--------
D
K
S
F
R
E
NYG
T
---------
L
G
-
L
A
----------
F
I
K
Q
Y
E
S
----------
K
K
D
V
Y
K
N
------
A
F
----------
E
S
Y
Q
R
Y
FNQKG---
S
N
-
E
I
M
Q
R
L
G
R
A
F
A
----
L
L
Q
V
T
G
E
V
L
N
DIDG-----FE
H
D
H
F
K
I
I
E
Q
--
A
Y
D
S
M
VK-------------NNKTID
K
P
K
Q
L
L
E
E
L
L
--
Q
Y
L
------DAN-RN-NIV---GDGYD---S-V------------NYGD--------
V
K
A
V
Y
K---H
D
F
L
C
IKN---
E
T
V
K
N
K
L---GH
E
M
Q
T
ITGQW-----DKKG
Y
L
I
------
K
D
K
K
R
I
Q
K
-
Q
V
K
H
------
K
-
S
Q
---
R
HL
G
Y
A
I
K
K
E
I
I
E
EL--------G-F
D
F
S----------------------I-SHNPYTE--SY---------------
37
Fugue
86.38
18%
3
- C5 -
1DIO
3
?
A:
[1-551]
---------------------------------------------
M
R
S
K
R
-------
F
E
A
L
A
K
--
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
-------
F
--------------------------
I
A
M
--------
E
S
P
N
D
-
P
K
P
S
I
---
K
--------
I
V
N
G
A
V
T
E
----
L
D
G
K
P
V
S
D
F
-
D
L
I
-
D
H
F
I
A
R
Y
G
I
N
L
---------
N
R
A
E
E
V
M
A
M
--------------
D
S
V
-----
K
L
A
N
M
L
C
D
P
N
------------------------------
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
----
K
I
V
E
V
V
S
H
M
N
V
V
--------
E
M
------
M
M
--------
A
M
Q
K
M
R
A
R
R
-----
T
P
------
S
-
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
-----
A
A
D
A
A
E
--
G
A
W
R
G
F
---
D
E
--------
Q
E
---
T
T
V
A
V
A
R
Y
A
P
F
-
N
A
-----
I
A
L
L
V
G
--
S
Q
V
---
G
R
-------
P
G
V
------
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
GHTCYA
E
T
I
S
V
Y
G
T
E
--------------
P
-------
V
F
T
D
G
-
D
-
D
-----
T
---
P
W
S
K
G
------
F
L
-
A
--
S
S
Y
A
---
S
----------------
R
G
L
K
M
R
F
T
--------------
S
G
S
G
---------
S
E
V
Q
M
G
Y
A
E
G
-
K
S
M
L
Y
L
------
E
A
R
C
I
Y
I
T
K
A
A
G
V
--
Q
----
G
L
Q
N
G
S
V
S
C
I
G
V
P
---------------
S
A
V
P
-------
S
G
I
R
A
-----------------
V
L
-
A
E
N
L
I
C
S
S
L
DLECASSN
D
Q
T
F
T
H
S
D
M
R
---------
R
T
-
A
R
----------
L
L
M
Q
F
L
P
----------
G
T
D
F
I
S
S
------
G
Y
----------
S
A
V
P
N
Y
D
N
M
F
A
---
G
S
-
N
E
D
A
E
D
F
D
D
Y
N
----
V
I
Q
R
D
L
K
V
----
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
--
A
A
R
A
L
Q
A
-------------
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
--
A
A
T
Y
AHGSK
D
M
P
-
E
R
-
N
I
V
---
E
D
I
K
F
---
A
-
Q
------------
E
I
I
N
K
NRN
G
L
E
V
V
K
A
L
A
Q
---
G
G
F
----
T
---
D
V
A
Q
D
M
L
---
N
I
Q
K
A
K
L
T
G
D
Y
-----
L
H
T
S
A
I
I
------
V
G
D
G
Q
V
L
S
-
A
V
N
D
------
V
-
N
D
YAG
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
--------
K
--
N
I
P
----------------------
G
-
A
L
D
P
N
---------------------
33
Fugue
78.29
16%
-0
- C4 -
4M59
3
?
A:
[6-714]
PD
A
Q
V
L
V
L
A
I
S
S
HPLPT
L
A
A
F
L
A
S
R
R
D
E
L
L
R
AD
I
T
S
L
L
K
A
L
E
L
S
G
H
W
E
W
A
-------
L
A
L
L
R
W
A
G
K
E
G
A
A
D
A
S
A
L
E
M
V
V
R
A
-------
L
G
R
E
G
Q
H
D
A
-----------------
V
C
A
L
L
D
E
T
P
L
P
P
G
S
R
L
D
-
V
R
A
Y
T
---
T
V
L
H
A
L
S
R
A
G
R
Y
E
R
A
L
E
----
L
F
A
E
L
R
R
Q
G
-
V
A
P
-
T
L
V
T
Y
N
V
V
L
D
V
Y
G
R
M
GRS
W
P
R
I
V
A
L
L
D
E
M
--------------
R
A
A
G
V
E
P
D
G
F
T
A
S
T
V
I
A
A
----------------------
C
S
R
D
G
L
V
D
E
A
V
A
F
F
E
D
L
K
A
R
G
H
A
P
-----
S
V
V
T
Y
N
A
L
L
Q
V
--------
F
G
KAGN
Y
T
E
A
--------
L
R
V
L
G
E
M
E
Q
-----
N
G
C
Q
P
D
A
V
T
-
Y
N
E
L
A
G
T
E
E
A
A
R
C
L
D
T
M
A
SP
N
A
F
T
Y
N
--
T
V
M
T
A
Y
---
G
N
V
GKV
D
E
A
L
A
L
---
F
D
Q
M
K
K
T
G
F
V
P
N
V
N
-----
T
Y
N
L
V
L
--
G
M
L
G
K
K
S
R
-
F
--
T
V
M
L
E
M
------
L
G
E
M
S
R
S
G
C
T
P
N
R
V
T
W
N
------
T
M
L
A
V
S
G
K
R
--------------
G
-------
M
E
D
Y
V
-
T
-
R
-----
V
---
L
E
G
M
R
S
S
G
V
E
L
S
R
-
D
--
T
Y
N
T
---
L
I
-------
A
A
Y
G
R
C
G
S
R
T
N
A
F
K
M
Y
--------------
N
E
M
T
------------
S
A
G
F
T
P
C
-
I
T
T
Y
N
A
L
L
N
V
L
S
R
Q
G
D
--
W
S
T
--
A
Q
--
S
----
I
V
S
K
M
R
T
K
G
F
K
P
N
---------------
E
Q
S
Y
-------
S
L
L
L
Q
-----------------
C
Y
-
A
K
G
G
N
V
A
G
I
--------
A
A
I
E
N
E
V
Y
G
S
GAVFPS
W
V
I
L
R
-
T
L
----------
V
I
A
N
F
K
C
----------
R
R
---
L
D
------
G
M
----------
E
T
A
F
Q
E
V
K
A
R
G
Y
N
P
D
L
-
V
I
F
N
S
M
L
S
I
Y
A
----
K
N
G
M
Y
S
K
A
T
E
V
F
D
S
-----
I
K
R
S
G
L
S
P
D
L
I
--
T
Y
N
S
L
M
D
-------------
M
Y
A
K
C
S
E
S
W
E
A
E
K
I
L
N
--
Q
L
K
------
C
S
Q
-
T
M
-
K
P
D
---
V
V
S
Y
N
---
T
-
V
------------
I
N
G
F
--------
C
K
Q
G
L
V
---
K
E
A
Q
R
V
L
S
---
E
M
V
A
D
G
M
A
P
C
A
V
T
Y
H
T
L
V
G
G
Y
-----
S
S
L
E
M
F
S
------
E
A
R
E
V
I
G
Y
-
M
V
Q
H
GLKPME
L
-
T
Y
---
R
R
V
V
E
S
Y
C
R
A
F
E
E
A
R
--------
G
-
F
L
S
E
----------------------
V
K
A
L
E
A
Y
I
E
--
D
A
---------------
28
Fugue
74.30
14%
-16
* C5 *
4GA6
3
AMPPA_THEKO
A:
[1-493]
------------------------------------M
K
A
K
I
R
I
L
D
M
F
S
G
R
-------
Y
T
V
L
I
N
E
E
D
A
K
E
A
K
L
H
P
D
D
L
V
K
I
E
-------
A
G
K
K
-
A
V
Y
G
-----------------
S
V
A
L
S
N
L
V
G
K
G
--------
E
V
G
I
---
S
--------
R
D
V
L
D
L
H
N
----------------------
F
S
E
G
E
T
V
---------
S
V
I
P
A
G
-------------------
T
-----
P
E
S
V
R
Y
I
K
K
K
----------------------
M
H
G
E
K
L
R
K
V
E
I
E
A
I
V
R
D
I
V
D
-----------------
R
K
L
--------
R
D
------
I
E
--------
I
S
S
F
V
T
A
L
E
-----
I
-------
N
-
G
L
----
D
M
D
E
I
A
A
L
T
-----
I
A
M
A
E
T
--
G
D
M
L
D
I
---
D
R
--------
K
P
---------------
I
M
-----
D
V
H
S
I
G
--
G
V
P
---
G
N
-
K
--
T
N
I
L
V
V
------
P
I
V
A
A
A
G
L
T
I
P
K
T
S
S
-
R
------
A
I
T
S
A
A
G
T
A
--------------
D
-------
V
V
E
V
F
-
A
-
D
-----
V
---
S
F
S
L
D
------
E
I
-
K
--
R
I
V
E
---
K
V
------------------
G
A
C
L
V
--------------
W
G
G
A
---------
L
N
L
A
-----------
P
A
D
D
I
T
I
K
A
E
R
A
L
S
I
D
P
--
T
G
--
L
----
M
L
A
S
I
M
S
K
K
Y
A
M
G
---------------
S
Q
Y
V
-------
L
I
D
I
P
T
G
KGV------------
K
V
-
E
T
V
E
E
A
R
S
L
--------
A
R
D
F
I
E
L
G
K
R
---------
L
G
Q
Y
V
----------
E
V
A
I
T
Y
G
----------
G
Q
P
I
G
H
T
VGP
A
L
E
A
R
----------
E
A
L
S
A
L
M
T
G
K
G
---
P
G
-
S
L
I
E
K
A
T
G
L
A
G
----
I
L
L
E
M
G
G
V
A
P
A
--------------
G
T
G
K
K
--
M
A
K
E
I
L
E
-------------
S
G
K
A
W
E
K
M
K
E
I
I
E
A
----
Q
G
G
------
D
P
N
-
I
K
----------
P
E
---
E
-
I
------------
P
I
G
D
--------
K
T
Y
T
F
T
-------
A
A
T
S
G
Y
V
T
A
I
D
N
R
A
---
I
T
A
I
A
R
A
A
G
A
P
-----
E
D
K
G
A
G
I
------
E
L
Y
V
K
V
G
E
-
K
V
K
E
------
G
-
D
P
---
L
F
T
I
H
A
E
H
E
A
R
L
D
Q
A
--------
I
-
V
L
A
R
----------------------
R
-
T
E
P
I
R
I
E
-------------------
34
Fugue
72.32
20%
0
- C3 -
4BQ2
7
?
A:
[2-747]
---------------------------------------SHMLFD
F
E
N
D
Q
VPSN
I
H
F
L
N
A
R
A
S
I
E
T
Y
T
G
I
N
G
E
P
S
K
G
L
K
L
A
-------
M
Q
S
K
-
Q
H
S
Y
T
G
L
A
I
V
P
EQPWDWSEFT
S
A
S
L
Y
F
D
I
V
S
V
G
D
H
S
T
Q
-
F
Y
L
D
V
---
T
--------
D
Q
N
G
A
V
F
T
----
R
S
I
D
I
P
V
G
K
M
Q
S
Y
-
Y
A
K
L
S
G
H
D
L
E
V
---------
P
D
S
G
D
V
N
D
L
NLASGLRSNPPTWT
S
D
D
-----
R
Q
F
V
W
M
W
G
V
K
NLDLSGIA
K
I
S
-----------
L
S
V
Q
S
A
M
H
D
K
T
V
I
I
D
N
I
R
I
Q
P
N
P
P
----
Q
D
E
N
F
L
V
G
L
V
D
E
--------
F
G
------
Q
N
AKVDYKGK
I
H
S
L
E
E
L
H
A
-----
A
-------
R
-
D
V
E
L
A
E
L
D
G
K
P
M
P
---------
S
R
S
K
FG
G
W
L
A
G
P
---
K
L
--------
K
A
TG
Y
F
R
T
E
K
I
N
G
K
W
M
-
L
V
D
PEG
Y
P
Y
F
A
T
G
--
L
D
I
---
I
R
-
L
--
S
---------------
N
S
S
T
M
T
G
Y
D
Y
D
Q
A
------
T
V
A
Q
R
--
S
A
--------------
D
-------
D
V
T
P
E
-
D
-
S
-----
K
---
G
L
M
A
V
------
S
E
-
K
--
S
F
A
T
---
R
H
LAS
P
T
R
A
A
M
F
-
N
W
L
P
D
Y
D
H
P
L
A
N
H
Y
N
Y
R
RSAHSGPLK
R
G
E
A
---------
Y
S
F
Y
S
A
N
L
E
R
-
K
Y
G
E
T
Y
P
G
S
Y
L
D
K
W
R
E
V
T
V
D
R
--
M
L
--
N
W
GFT
S
L
G
N
W
T
D
P
A
Y
Y
D
N
---------------
N
R
I
P
-------
F
F
A
N
G
W
VIGD
F
K
T
V
S
SGADFW
G
A
M
-
P
D
V
F
D
-
P
E
F
--------
K
V
R
A
M
E
T
A
R
V
---------
V
S
-
E
E
I
KNSPWCV
G
V
F
I
D
N
E
K
S
FG--------
R
P
D
S
D
K
A
------
Q
Y
----------
G
I
P
I
H
T
L
G
R
P
S
---
E
G
V
P
T
R
Q
A
F
S
K
L
L
K
----
A
K
Y
K
T
I
A
A
L
N
N
A
W
G
-----
L
K
L
S
S
W
A
E
F
D
L
--
G
V
D
--
V
K
-------------
A
L
P
V
T
D
T
L
R
A
D
Y
S
M
L
L
--
S
A
Y
------
A
D
Q
-
Y
F
-
K
V
V
---
H
G
A
V
E
---
H
-
Y
MPN
H
L
Y
L
G
ARFP
D
W
G
M
P
M
E
V
----
V
K
A
A
A
K
---
Y
A
D
V
V
S
Y
N
----
S
Y
K
E
G
L
---
P
K
Q
K
W
A
F
L
A
E
L
-----
D
K
P
S
I
I
G
E
F
H
I
G
A
M
D
H
G
S
Y
H
P
-
G
L
I
H
------
A
-
A
S
---
Q
A
D
R
G
E
M
Y
K
D
Y
M
Q
S
V
I
D
NPYFV
G
A
-
H
W
F
Q
YMDSPLTGRAYDGENYNVGFVD
V
-
T
D
T
P
Y
Q
E
--
M
V
D
A
A
K
E
V
N
A
K
I
YTERL
32
Fugue
70.00
12%
-12
- C4 -
4MHC
-
NU157_YEAST
A:
[21-825]
----------------------------------------------
S
E
P
L
-------
Q
L
A
S
E
F
V
Q
D
L
S
F
R
D
R
N
T
P
I
L
D
N
P
D
YYSKGLD
Y
N
F
S
-
D
E
V
G
-----------------
G
L
G
A
F
T
P
F
Q
R
Q
Q
V
T
N
I
P
-
D
E
V
L
S
Q
V
S
N
--------
T
E
I
K
S
D
M
G
----
I
F
L
E
L
N
Y
C
W
-
I
T
S
D
N
K
L
I
L
W
N
I
N
N
S
---------
S
E
Y
H
C
I
D
E
I
--------------
E
H
T
-----
I
L
K
V
K
L
V
K
P
S
PNTFVSSVE
N
L
L
I
V
A
T
LF
D
I
Y
I
L
T
I
S
F
N
D
R
T
H
E
L
N
I
F
N
T
G
L
K
V
N
V
T
GFNV
S
N
I
I
S
Y
E
R
T
G
Q
I
F
F
T
G
ATDG
V
N
------
V
W
--------
E
L
Q
Y
N
K
I
C
L
T
KSNL
E
-------
E
-
T
I
S
Q
L
E
V
D
Q
S
-
R
G
V
L
-----
H
T
L
S
T
K
--
S
I
V
R
S
Y
L
I
T
S
N
--------
G
L
---
V
G
P
V
L
I
D
A
A
H
I
-
R
R
-----
G
M
N
A
L
G
--
V
K
N
---
S
P
-
L
--
L
S
N
R
A
F
K-----
I
A
K
I
V
S
I
S
M
C
E
N
N
D
L
F
L
------
A
V
I
T
T
T
G
V
R
--------------
L
-------
Y
F
K
G
S
-
I
-
S
-----
R
---
R
S
I
G
S
------
L
K
-
L
--
D
S
V
K
---
F
P
-------
P
T
S
-
G
P
L
S
T
Q
K
A
S
S
T
Y
--------------
I
N
T
T
CA
S
T
I
I
S
PG
I
Y
F
T
C
V
R
K
R
A
-
E
H
K
L
Y
V
S
A
P
D
Y
G
I
L
K
N
Y
G
K
Y
V
--
E
N
--
T
----
A
L
L
D
T
T
D
E
I
K
E
I
V
P
LTRSFNYTSTPQGY
A
N
V
F
-------
A
S
Q
Y
S
-----------------
A
E
-
P
L
K
V
A
V
L
T
S
--------
N
A
L
E
I
Y
C
Y
R
T
---------
P
D
-
E
V
----------
F
E
S
L
I
E
N
----------
P
L
P
F
I
H
S
YG
L
S
E
-
A
C
----------
S
T
A
L
Y
L
A
C
K
F
N
---
K
S
-
E
H
I
K
S
S
A
L
A
F
F
----
S
A
G
I
P
G
V
V
E
I
K
P
K
S
-----
V
L
S
P
R
F
Y
G
S
A
L
--
L
I
T
R
L
F
S
QIWEERVFVGISI
T
R
P
Q
V
E
Y
Y
L
S
S
I
S
V
L
A
--
D
F
F
------
N
I
H
-
R
P
-
S
F
V
---
S
T
A
S
D
---
A
-
E
------------
S
I
A
---------
M
N
A
L
I
L
---
L
I
N
S
I
K
D
A
---
L
S
L
I
N
V
F
---
Y
E
D
I
D
A
F
K
S
L
L
-----
N
T
L
M
Y
D
S
------
K
T
R
E
Y
F
F
D
L
K
F
H
D
------
L
F
T
P
---
N
A
K
T
K
Q
L
I
K
E
I
L
I
E
V
--------
V
-
N
A
-
N
----------------------
I
-
A
S
G
T
S
A
D
--
Y
I
V
N
V
L
K
E
RF-------
36
Fugue
69.02
19%
-18
- C2 -
5A07
3
?
A:
[40-434]
---------------------------------------------------------------
D
H
D
A
E
V
L
D
S
I
M
D
R
L
H
E
P
L
-------
Y
E
K
D
-
T
------------------------
F
D
P
N
E
V
L
A
E
N
K
Q
L
-
Y
E
E
F
L
---
L
--------
Q
E
I
S
E
P
K
V
D
N
L
V
R
S
G
D
P
L
A
G
K
-
A
K
G
-
T
I
L
S
L
-----
V
---------
R
N
S
D
L
E
D
I
I
--------------
S
S
I
-----
Q
Q
L
E
E
E
Y
N
K
N
----------------------
F
G
Y
P
-------
Y
T
F
L
N
-
D
E
E
F
T
D
E
----
F
K
D
G
I
K
S
I
L
P
K
D
--------
R
-----------------
V
V
E
F
G
T
I
G
P
-----
D
-------
N
W
N
M
P
D
S
I
D
R
E
R
Y
D
Q
E
M
-----
D
K
M
S
K
E
--
N
-
I
Q
Y
A
---
E
V
--------
E
S
---
Y
H
N
M
C
R
F
Y
S
K
E
-
F
Y
-----
H
H
P
L
L
S
KY
K
Y
V
---
W
R
L
E
--
P
N
V
N
F
Y
C
KINYD
V
F
Q
F
M
N
K
N
D
K
I
Y
G
F
V
L
N
------
L
Y
D
S
---
P
Q
--------------
T
-------
I
E
T
L
W
-
T
-
S
-----
T
---
M
D
F
V
E
------
E
H
-
P
--
N
Y
L
N
VNG
A
F
-------
A
W
L
-
K
D
N
S
Q
N
---------------------
P
K
N
---------
Y
D
Y
T
Q
G
Y
S
-----------------------------------------------------------------------------------------------------
T
C
H
F
W
T
---------------
N
F
E
I
---------
V
D
-
L
D
----------
F
L
R
S
-------------------
E
------
P
Y
----------
E
K
Y
M
Q
Y
L
E
E
K
G
----------------------------------
G
-----
F
Y
Y
E
R
W
----------------------------------
G
D
A
P
V
R
S
L
A
--
L
A
L
------
F
A
D
-
K
S
-
S
I
H
WFR
D
I
G
Y
H
---
H
-
T
------------
P
Y
T
N
--------
C
P
T
C
P
A
---
D
S
D
R
C
N
G
N
---
C
V
---------------------------------------
P
G
K
F
T
P
-
W
S
D
L
------
D
-
N
Q
---
N
C
Q
A
T
W
I
R
H
S
M
S
E
E
E
--------
L
-----------------------------------
E
--
M
Y
---------------
30
Fugue
65.82
12%
-15
- C4 -
4XGC
-
?
C:
[1-676]
---------------------------------------------
M
Q
--------------
P
F
Y
E
E
Y
R
K
A
W
N
Q
I
N
D
H
I
A
D
L
-------
Q
H
R
S
-
Y
A
R
T
-----------------
L
E
Q
L
V
D
F
V
V
G
Q
A
E
R
D
E
V
L
P
T
A
A
L
---
L
--------
T
G
I
N
Q
P
D
H
---------
L
S
Q
F
-
T
A
L
-
T
Q
R
L
H
A
Q
R
A
A
M
---------
V
C
V
L
Q
S
R
D
C
--------------
A
T
L
-----
K
A
A
V
E
T
L
V
F
G
----------------------
L
V
E
D
N
A
E
V
E
Q
L
R
-------------------
R
S
Q
C
T
M
K
Q
L
--------
K
S
------
W
Y
--------
T
N
N
F
D
S
E
Q
K
-----
R
-------
R
-
Q
L
V
V
I
L
P
D
------
F
-----
E
C
F
-
N
A
--
S
V
L
Q
D
L
---
I
L
--------
I
L
---
S
A
H
C
G
S
L
P
F
V
L
-
V
L
-----
G
V
A
T
A
M
--
T
A
V
---
H
G
-
T
L
P
Y
H
V
S
S
K
------
I
R
L
R
V
F
Q
T
Q
A
A
P
T
G
L
N
E
------
V
L
D
K
V
--------------------------
L
L
S
P
K
-
Y
-
A
-----
F
---
H
L
S
G
K
------
T
F
-
K
--
F
L
T
H
---
I
F
-------
L
Y
Y
-
D
F
S
I
H
G
F
I
Q
G
F
K
--------------
Y
C
L
M
---------
E
H
F
F
G
G
N
A
F
A
L
C
T
D
Y
S
K
A
L
G
R
I
K
Q
L
T
H
E
D
M
E
T
--
I
R
R
L
P
----
S
F
R
P
Y
V
E
Q
I
N
D
C
K
---------------
R
I
I
A
-------
V
L
T
D
D
-----------------
D
Y
L
K
K
K
L
P
Q
L
L
R
--------
D
C
L
L
H
F
L
L
F
R
---------
C
S
-
L
E
----------
F
L
T
E
L
V
G
D
LPRCPLGKL
R
R
E
L
Y
V
N
------
C
L
N
RAIIST
P
E
Y
K
E
C
L
Q
M
L
S
F
L
S
---
K
D
-
E
F
V
A
K
V
N
R
A
L
E
R
T
E
Q
F
L
V
E
E
I
A
P
L
E
L
G
E
A
-----
C
T
A
V
L
R
P
K
L
E
A
--
I
R
L
A
V
D
E
-------------
V
G
R
A
L
Q
K
T
L
Q
L
I
E
T
Q
I
VQ
D
H
L
------
R
A
L
-
Q
D
A
P
P
I
---
H
E
L
F
V
---
F
-
S
------------
D
I
A
T
--------
V
R
R
N
I
I
---
G
A
P
R
A
A
L
H
---
T
A
L
N
N
P
H
---
F
P
D
L
S
V
V
Y
K
L
H
-----
L
E
C
G
R
M
I
------
N
L
F
D
W
L
Q
A
-
F
R
S
V
------
V
-
P
Q
---
I
Q
A
R
F
T
R
A
V
A
E
L
Q
F
L
--------
G
Y
I
K
M
S
----------------------
K
-
R
K
T
D
H
A
T
R
L
T
W
---------------
31
Fugue
60.10
17%
3
- C4 -
4NLE
-
?
A:
[18-485]
----------------------------------------------------------
T
I
P
N
V
L
A
N
R
Y
A
S
D
E
M
V
A
I
W
S
P
E
A
-------
K
I
I
A
-
E
R
R
L
-----------------
W
L
A
V
L
R
A
Q
A
E
L
G
V
A
V
P
D
-
G
---------------------
V
V
E
----
D
Y
E
R
V
L
E
N
--
V
D
L
-
E
S
I
A
A
R
E
R
V
R
H
---------
D
V
K
A
R
I
E
E
F
--------------
N
A
H
-----
E
H
----
V
H
K
G
----------------------
M
--
T
S
R
D
L
T
E
N
V
E
Q
L
Q
I
R
Q
S
L
E
L
V
----
F
S
H
G
V
A
V
-
V
A
R
L
--------
A
E
------
R
A
--------
V
V
Y
R
D
L
V
M
A
-----
G
-------
R
-
S
H
N
V
A
A
Q
A
T
T
-----------------------
L
---
G
K
--------
R
F
---
A
S
A
A
E
E
T
L
V
A
L
-
T
R
-----
L
R
E
L
I
D
--
R
Y
P
---
L
R
-----
G
V
K
-------------
G
P
M
G
T
A
--------------------
Q
--------------
D
-------
M
L
D
L
F
-
G
-
G
-----
D
---
V
G
K
L
A
------
D
L
-
E
--
R
R
V
A
---
E
F
-------
L
G
F
-
T
E
V
F
T
-------------------------------------
S
V
G
Q
V
Y
P
-
R
S
L
D
H
D
V
L
S
A
L
V
Q
F
-----
G
A
--
G
P
--
S
----
S
M
A
H
T
I
R
L
M
A
G
-----------------
H
E
L
V
-------
T
E
G
F
A
-----------------
P
G
-
Q
V
G
--------------
S
S
A
M
P
H
K
M
N
T
---------
R
S
-
C
E
----------
R
V
N
G
L
Q
V
----------
V
L
R
G
Y
A
S
------
M
A
----------
A
E
L
A
G
--
A
Q
W
N
---
E
G
-
D
V
F
C
S
V
V
R
R
V
A
----
L
----
P
D
A
F
F
A
I
D
G
-----
Q
T
E
T
F
L
T
V
L
D
E
F
G
A
Y
-------------------------
P
A
V
I
Q
R
E
L
D
--
R
Y
L
------
P
F
L
A
T
T
-
R
I
L
---
M
A
A
V
R
---
A
G
V
------------
G
R
E
A
--------
A
H
E
V
I
K
---
E
H
A
V
A
V
A
L
---
A
M
R
E
Q
-----
G
R
E
P
D
-
L
I
D
R
L
-----
A
G
D
P
R
L
P
------
L
D
K
V
A
L
E
A
-
A
L
E
D
--------
K
Q
---
A
F
T
G
A
A
G
D
Q
V
D
G
V
V
A
--------
A
-
V
G
E
L
----------------------
V
-
S
R
Y
P
E
A
A
--
K
Y
TSG------------
7
PsiBlast_PDB
51.25
23%
-15
- C6 -
3SD7
4
?
A:
[26-151]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
N
Y
E
I
V
L
F
D
--
L
D
--
G
----
T
---
L
T
D
P
K
E
G
I
T
---------------
K
S
I
Q
Y
S
L
N
S
F
G
I
K
E
D
L
-----------------
E
N
-
L
D
Q
F
I
G
P
P
L
--------
H
D
T
F
K
E
Y
Y
-----------------------------
K
F
E
D
----------
K
K
A
--
K
E
------
A
V
----------
E
K
Y
R
E
Y
F
A
D
K
G
IF-
E
N
-
K
I
Y
E
N
M
K
E
I
L
E
----
M
L
Y
K
N
G
K
I
L
---------------------------
L
V
A
-------------
T
S
----
K
P
T
V
F
A
E
T
I
L
--
R
Y
F
------
D
I
D
-
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
47.81
28%
16
- C6 -
3LZE
1
?
A:
[59-153]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
-
N
I
Q
---
G
D
G
Y
V
ID
F
S
-
I
------------
L
K
E
K
--------
V
R
K
V
C
K
Q
L
D
H
H
F
I
L
P
M
Y
---
S
D
V
L
N
--------
I
Q
E
V
N
D
N
F
K
I
T
C
E
D
N
S
E
Y
S
F
------
P
K
R
D
C
V
Q
I
-
P
I
K
H
------
S
-
S
T
---
E
E
I
G
L
Y
I
L
N
Q
L
I
E
E
I
--------
D
-
L
P
F
---------------------------------------------------
2
PsiBlast_PDB
47.39
28%
18
- C6 -
3M0N
1
?
A:
[59-153]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
-
N
I
Q
---
G
D
G
Y
V
ID
F
S
-
I
------------
L
K
E
K
--------
V
R
K
V
C
K
Q
L
D
H
H
F
I
L
P
M
Y
---
S
D
V
L
N
--------
I
Q
E
V
N
D
N
F
K
I
T
C
E
D
N
S
E
Y
S
F
------
P
K
R
D
C
V
Q
I
-
P
I
K
H
------
S
-
S
T
---
E
E
I
G
L
Y
I
L
N
Q
L
I
E
E
I
--------
D
-
L
P
F
---------------------------------------------------
4
PsiBlast_PDB
46.55
28%
19
- C6 -
2A0S
1
?
A:
[59-153]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
-
N
I
Q
---
G
D
G
Y
V
ID
F
S
-
I
------------
L
K
E
K
--------
V
R
K
V
C
K
Q
L
D
H
H
F
I
L
P
M
Y
---
S
D
V
L
N
--------
I
Q
E
V
N
D
N
F
K
I
T
C
E
D
N
S
E
Y
S
F
------
P
K
R
D
C
V
Q
I
-
P
I
K
H
------
S
-
S
T
---
E
E
I
G
L
Y
I
L
N
Q
L
I
E
E
I
--------
D
-
L
P
F
---------------------------------------------------
5
PsiBlast_PDB
46.38
28%
22
- C6 -
3LX3
1
?
A:
[59-153]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
-
N
I
Q
---
G
D
G
Y
V
ID
F
S
-
I
------------
L
K
E
K
--------
V
R
K
V
C
K
Q
L
D
H
H
F
I
L
P
M
Y
---
S
D
V
L
N
--------
I
Q
E
V
N
D
N
F
K
I
T
C
E
D
N
S
E
Y
S
F
------
P
K
R
D
C
V
Q
I
-
P
I
K
H
------
S
-
S
T
---
E
E
I
G
L
Y
I
L
N
Q
L
I
E
E
I
--------
D
-
L
P
F
---------------------------------------------------
8
HHSearch
44.40
12%
32
- C6 -
1TUE
-
VE1_HPV18
A:
[477-596]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
------
C
L
V
F
C
G
P
A
N
T
G
K
S
Y
F
G
M
------
S
F
I
H
F
I
Q
G
A
--------------
V
-------
I
--
S
F
-
V
-
N
ST---
S
---
H
F
W
L
----------
E
--
P
L
T
D
---
T
K
-------
V
A
M
-
L
D
D
A
T
T
T
C
W
T
Y
F
--------------
D
T
Y
M
---------
R
N
A
L
D
G
N
P
I
S
-
I
D
----
P
--
L
I
Q
L
K
C
P
P
I
L
L
T
--
T
N
--
I
----
H
P
A
K
D
-
N
R
W
P
Y
L
E
---------------
S
R
I
T
-------
V
F
E
F
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
43.81
16%
49
- C6 -
3SYL
1
CBBX_RHOSH
A:
[66-148]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
------
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
------
K
M
A
G
L
L
H
R
L
GYVRKG
H
L
V
S
V
T
RD
D
-------
L
V
G
Q
Y
I
G
-
H
-----
T
---
A
P
K
T
K
------
E
V
-
L
--
K
R
A
M
---
G
G
-------
V
L
F
-
I
D
E
A
Y
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
39.90
15%
74
- C6 -
3PFI
1
?
A:
[54-130]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
L
D
------
H
I
L
F
S
G
P
A
G
L
G
K
T
T
L
A
N
------
I
I
S
Y
E
M
S
A
N
--------------
I
K
T
-----
T
A
A
P
M
-
I
-
E
-----
K
---
S
G
D
L
A
------
A
I
L
T
--
N
L
S
E
---
G
D
-------
I
L
F
-
I
D
E
I
H
R
L
S
P
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
39.66
16%
81
- C6 -
3WHK
1
PAN_PYRFU (first)
A:
[51-132]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
------
G
V
L
L
Y
G
P
P
G
C
G
K
T
L
M
A
K
------
A
I
A
H
E
V
N
A
T
--------------
F
I
R
V
V
GSE
L
V
R
-----
E
-----
G
A
R
L
V
H
E
L
F
------
E
L
-
A
--
K
E
K
A
---
P
T
-------
I
I
F
-
I
D
E
I
D
A
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
39.61
16%
79
- C6 -
3VFD
1
SPAST_HUMAN
A:
[147-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
R
------
G
L
L
L
F
G
P
P
G
N
G
K
T
M
L
A
K
------
A
V
A
A
E
S
N
A
T
F
F
N
I
SAA-------
S
-------
L
--------G
E
K
--
L
---
V
R
A
L
F
------
A
V
-
A
--
R
E
L
Q
---
P
S
-------
I
I
F
-
I
D
Q
V
D
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
39.53
18%
81
- C6 -
1D2N
2
A:
[63-136]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
V
------
S
V
L
L
E
G
P
P
H
S
G
K
T
A
L
A
A
------
K
I
A
E
E
S
N
F
P
F
I
K
I
C
S
P-------
D
-------
K
M
I
G
F
-
S
-
E
T
A
K
C
Q
A
---
M
K
K
I
F
------
D
D
-
A
--
Y
K
S
Q
---
L
S
-------
C
V
V
-
V
D
D
I
E
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
39.06
13%
50
- C6 -
1HQC
2
RUVB_THET8
A:
[38-104]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
------
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
------
V
I
A
H
E
L
G
V
N
--------------
L
R
------
V
T
S
G
P
-
A
I
E
-----
K
---
P
G
D
L
A
------
A
I
-
L
A
N
S
L
E
E
---
G
D
-------
I
L
F
-
I
D
E
I
H
R
L
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------