@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1927: (2016-03-30 )
MPLVSMKEMLIDAKENGYAVGQYNINNLEFTQAILEASQEENAPVILGVSEGAARYMSGFYTIVKMVEGLMHDLNITIPVAIHLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQEDDVVADGIIYADPKECQELVEKTGIDALAPALGSVHGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQIASAKAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEFGTSNRAK
Atome Classification :
(26 SA)
--.........10........20........30........40........50........---60........70...-.....80......-----------..90........100.......110.......120.......130.......140.......150-..-......160.......170.......180.--..---.--.--..190.......200.........210---------------------...---------------------.---------------------.----------..220.....---------....230.......240.......250.-......260.......270.......280....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MPL
V
S
M
K
E
M
L
I
DAKEN
G
Y
A
V
G
QYNI
N
N
L
E
F
T
Q
A
I
L
E
ASQEENA
P
V
I
L
G
VSE
G
A
A
R
Y
M
S
G
---
F
Y
T
I
V
K
M
V
E
G
L
M
HDL-
N
I
T
I
P
V
A
I
H
LDHG-----------S
S
F
E
K
C
K
E
A
I
D
AGF
T
S
V
M
I
DASHS
P
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
EKG
V
S
V
E
A
ELGTVGGQEDDVVAD--
G
I
-
I
YA
D
P
K
E
C
Q
E
L
V
E
KTG
I
D
A
L
A
P
A
L
G
SVHGP--YK---G--E--PKL
G
F
K
E
M
E
E
IGL--STGL
P
L
V
L
HGGT---------------------GI
P
---------------------
T
---------------------
K
----------
D
I
Q
--
K
AIPF---------G
T
A
K
I
N
VNTENQI
A
S
A
K
A
V
R
D
V
LNNDKE-VY
D
P
R
K
YL
G
P
A
R
E
A
I
K
E
T
V
K
G
K
I
K
E
FGTSNRAK
21
PsiBlast_CBE
95.09
100%
-79
- C3 -
4TO8
2
?
B:
[2-286]
---
P
L
V
S
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
G
A
A
R
Y
M
S
G
---
F
Y
T
I
V
K
M
V
E
G
L
M
H
D
L
-
N
I
T
I
P
V
A
I
H
L
D
H
G
-----------
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
S
P
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
G
--
D
D
V
V
A
D
--
G
I
-
I
Y
A
D
P
K
E
C
Q
E
L
V
E
K
T
G
I
D
A
L
A
P
A
L
G
S
V
H
---------------
P
K
L
G
F
K
E
M
E
E
I
G
L
--
S
T
G
L
P
L
V
L
H
G
G
T
---------------------
G
I
P
---------------------
T
---------------------
K
----------
D
I
Q
--
K
A
I
P
F
---------
G
T
A
K
I
N
V
N
T
E
N
Q
I
A
S
A
K
A
V
R
D
V
L
N
N
D
K
E
-
V
Y
D
P
R
K
Y
L
G
P
A
R
E
A
I
K
E
T
V
K
G
K
I
K
E
F
G
T
S
N
R
A
K
1
PsiBlast_PDB
94.58
100%
-80
- C3 -
4TO8
2
?
A:
[2-286]
---
P
L
V
S
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
G
A
A
R
Y
M
S
G
---
F
Y
T
I
V
K
M
V
E
G
L
M
H
D
L
-
N
I
T
I
P
V
A
I
H
L
D
H
G
-----------
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
S
P
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
G
--
D
D
V
V
A
D
--
G
I
-
I
Y
A
D
P
K
E
C
Q
E
L
V
E
K
T
G
I
D
A
L
A
P
A
L
G
S
V
H
G
--------------
P
K
L
G
F
K
E
M
E
E
I
G
L
--
S
T
G
L
P
L
V
L
H
G
G
T
---------------------
G
I
P
---------------------
T
---------------------
K
----------
D
I
Q
--
K
A
I
P
F
---------
G
T
A
K
I
N
V
N
T
E
N
Q
I
A
S
A
K
A
V
R
D
V
L
N
N
D
K
E
-
V
Y
D
P
R
K
Y
L
G
P
A
R
E
A
I
K
E
T
V
K
G
K
I
K
E
F
G
T
S
N
R
A
K
2
PsiBlast_PDB
90.90
73%
-75
- C3 -
3Q94
10
?
A:
[5-288]
---
P
L
V
S
M
K
E
M
L
N
K
A
L
E
G
K
Y
A
V
G
Q
F
N
M
N
N
L
E
W
T
Q
A
I
L
A
A
A
E
E
E
K
S
P
V
I
L
G
V
S
E
G
A
A
R
H
M
T
G
---
F
K
T
V
V
A
M
V
K
A
L
I
E
E
M
-
N
I
T
V
P
V
A
I
H
L
D
H
G
-----------
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
H
P
F
E
E
N
V
E
T
T
K
K
V
V
E
Y
A
H
A
R
N
V
S
V
E
A
E
L
G
T
V
G
G
Q
E
D
D
V
I
A
E
--
G
V
-
I
Y
A
D
P
A
E
C
K
H
L
V
E
A
T
G
I
D
C
L
A
P
A
L
G
S
V
H
G
P
--
Y
K
---
G
--
E
--
P
N
L
G
F
A
E
M
E
Q
V
R
D
--
F
T
G
V
P
L
V
L
H
G
G
T
---------------------
G
I
P
---------------------
T
---------------------
A
----------
D
I
E
--
K
A
I
S
L
---------
G
T
S
K
I
N
V
N
T
E
N
Q
I
E
F
T
K
A
V
R
E
V
L
N
K
D
Q
E
-
V
Y
D
P
R
K
F
I
G
P
G
R
D
A
I
K
A
T
V
I
G
K
I
R
E
F
G
S
N
G
K
A
-
34
PsiBlast_CBE
80.96
44%
-72
- C3 -
3C56
3
ALF_HELPY
B:
[2-306]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
-
G
---
I
D
M
A
V
G
M
V
K
-
I
M
C
E
R
-
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
--------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
FK
F
K
---
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
--
L
T
N
I
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
V
R
K
S
Y
L
D
A
GG
D
L
K
GS
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
--
7
PsiBlast_PDB
80.84
44%
-71
- C3 -
3C56
3
ALF_HELPY
A:
[2-306]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
-
G
---
I
D
M
A
V
G
M
V
K
-
I
M
C
E
R
-
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
-
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
FK
F
K
---
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
--
L
T
N
I
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
V
R
K
S
Y
L
D
A
GG
D
L
K
GS
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
--
6
PsiBlast_PDB
80.02
44%
-74
- C3 -
3C52
4
ALF_HELPY
A:
[2-306]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
-
G
---
I
D
M
A
V
G
M
V
K
-
I
M
C
E
R
-
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
FK
F
K
---
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
--
L
T
N
I
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
GS
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
--
31
PsiBlast_CBE
79.84
44%
-73
- C3 -
3N9R
4
?
P:
[2-306]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
-
G
---
I
D
M
A
V
G
M
V
K
-
I
M
C
E
R
-
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
-
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
FK
F
K
---
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
--
L
T
N
I
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
VRKSYLDAGG
D
L
K
GS
K
G
V
P
F
EFLQESVKG
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
--
30
PsiBlast_CBE
79.53
44%
-71
- C3 -
3N9R
2
?
U:
[2-306]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
-
G
---
I
D
M
A
V
G
M
V
K
-
I
M
C
E
R
-
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
-
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
FK
F
K
---
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
--
L
T
N
I
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
VRKSYLDAGG
D
L
K
GS
K
G
V
P
F
EFLQESVKG
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
--
29
PsiBlast_CBE
79.43
44%
-72
- C3 -
3N9R
14
?
Z:
[2-306]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
-
G
---
I
D
M
A
V
G
M
V
K
-
I
M
C
E
R
-
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
-
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
FK
F
K
---
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
--
L
T
N
I
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
VRKSYLDAGG
D
L
K
GS
K
G
V
P
F
EFLQESVKG
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
--
53
HHSearch
79.41
49%
-59
- C3 -
1RVG
8
?
A:
[1-305]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
G
G
-----
R
A
L
T
L
M
A
V
E
L
--
A
K
-
E
A
R
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
----
K
--
D
A
-
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
--
Y
K
---
G
K
G
R
--
P
F
I
D
H
A
R
L
E
R
I
A
R
--
L
V
P
A
P
L
V
L
H
G
A
S
AVP
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
EAA
G
I
H
---------------------
P
---------------------
E
----------
D
I
K
--
K
A
I
S
L
---------
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
-
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
38
PsiBlast_CBE
79.25
41%
-74
- C3 -
1GVF
12
KBAY_ECOLI
B:
[2-283]
---
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
A
----
L
E
E
I
Y
A
L
C
S
A
Y
S
T
T
Y
-
N
M
--
P
L
A
L
H
L
D
H
H
-----------
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
G
V
E
--------
S
A
-
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
--
Y
S
---
K
--
T
--
P
K
I
D
F
Q
R
L
A
E
I
R
E
--
V
V
D
V
P
L
V
L
H
G
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
----------
F
V
R
--
R
T
I
E
L
---------
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
-
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
--
23
PsiBlast_CBE
79.08
44%
-67
- C3 -
1RVG
6
?
C:
[2-305]
----
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
--
G
---
G
R
A
L
T
L
M
A
V
E
L
A
K
E
A
-
R
V
--
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
D
EK
D
A
-
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
--
Y
K
---
G
--
K
GR
P
F
I
D
H
A
R
L
E
R
I
A
R
--
L
V
P
A
P
L
V
L
H
G
A
S
---------------------
A
V
P
PELVERFRASGGEIGEAAGIH
P
---------------------
E
----------
D
I
K
--
K
A
I
S
L
---------
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
-
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
33
PsiBlast_CBE
78.95
44%
-71
- C3 -
3N9R
4
?
B:
[2-306]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
-
G
---
I
D
M
A
V
G
M
V
K
-
I
M
C
E
R
-
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
-
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
FK
F
K
---
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
--
L
T
N
I
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
VRKSYLDAGG
D
L
K
GS
K
G
V
P
F
EFLQESVKG
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
--
35
PsiBlast_CBE
78.84
44%
-74
- C3 -
3C4U
2
ALF_HELPY
B:
[2-306]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
-
G
---
I
D
M
A
V
G
M
V
K
-
I
M
C
E
R
-
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
----------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
FK
F
K
---
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
--
L
T
N
I
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
VRKSYLDAGG
D
L
K
GS
K
G
V
P
F
EFLQESVKG
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
--
13
PsiBlast_PDB
78.78
41%
-77
- C3 -
1GVF
11
KBAY_ECOLI
A:
[2-283]
---
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
A
----
L
E
E
I
Y
A
L
C
S
A
Y
S
T
T
Y
-
N
M
--
P
L
A
L
H
L
D
H
H
-----------
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
-----------
S
A
-
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
--
Y
S
---
K
--
T
--
P
K
I
D
F
Q
R
L
A
E
I
R
E
--
V
V
D
V
P
L
V
L
H
G
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
----------
F
V
R
--
R
T
I
E
L
---------
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
-
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
--
52
HHSearch
78.49
41%
-71
* C3 *
1GVF
11
KBAY_ECOLI
A:
[2-285]
---
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
A
----
L
E
E
I
Y
A
L
C
S
A
Y
--
S
T
-
T
Y
N
M
P
L
A
L
H
L
D
H
H
-----------
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
-----------
S
A
-
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
--
Y
S
---
K
--
T
--
P
K
I
D
F
Q
R
L
A
E
I
R
E
--
V
V
D
V
P
L
V
L
H
G
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
----------
F
V
R
--
R
T
I
E
L
---------
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
-
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
S
12
PsiBlast_PDB
78.44
44%
-64
- C3 -
2FJK
1
ALF_THECA
A:
[2-305]
----
L
V
T
G
L
E
I
L
R
K
A
R
A
E
G
Y
G
V
G
A
F
N
T
N
N
M
E
F
T
Q
A
I
L
E
A
A
E
E
M
K
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
--
G
---
G
R
A
L
T
R
M
V
V
A
L
A
Q
E
A
-
R
V
--
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
K
A
L
R
E
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
K
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
D
E
K
D
A
-
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
--
Y
K
---
G
--
K
GR
P
F
I
D
H
P
R
L
A
R
I
A
K
--
L
V
P
A
P
L
V
L
H
G
A
S
---------------------
A
V
P
---------------------
Q
E
L
V
E
R
F
R
A
A
G
G
E
I
G
EASGIH
P
E
----------
D
I
K
--
K
A
I
S
L
---------
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
V
R
E
T
L
G
K
N
P
K
-
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
8
PsiBlast_PDB
78.44
44%
-72
- C3 -
3N9R
4
?
A:
[2-306]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
-
G
---
I
D
M
A
V
G
M
V
K
-
I
M
C
E
R
-
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
-
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
FK
F
K
---
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
--
L
T
N
I
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
V
R
K
S
Y
L
D
A
GG
D
L
K
GS
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
--
3
PsiBlast_PDB
78.44
44%
-66
- C3 -
1RV8
7
?
A:
[2-305]
----
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
--
G
---
G
R
A
L
T
L
M
A
V
E
L
A
K
E
A
-
R
V
--
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
-------K-
D
A
-
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
--
Y
K
---
G
--
K
G
R
P
F
I
D
H
A
R
L
E
R
I
A
R
--
L
V
P
A
P
L
V
L
H
G
A
S
---------------------
A
V
P
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
EAAGIH
P
---------------------
E
----------
D
I
K
--
K
A
I
S
L
---------
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
-
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
32
PsiBlast_CBE
78.15
44%
-71
- C3 -
3N9R
4
?
K:
[2-306]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
-
G
---
I
D
M
A
V
G
M
V
K
-
I
M
C
E
R
-
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
-
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
FK
F
K
---
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
--
L
T
N
I
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
VRKSYLDAGG
D
L
K
GS
K
G
V
P
F
EFLQESVKG
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
--
10
PsiBlast_PDB
77.85
42%
-74
- C3 -
2ISV
2
?
A:
[2-307]
---
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
D
M
---
I
Y
-
L
K
K
L
C
E
A
A
L
-
E
K
-
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
------------------
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
--------------
R
L
A
I
D
R
V
K
T
I
S
D
--
L
T
G
I
P
L
V
M
H
G
S
S
SVP
K
D
V
K
D
M
I
N
K
Y
GGKMPDAV
G
V
P
---------------------
I
---------------------
E
----------
S
I
V
--
H
A
I
G
E
---------
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
28
PsiBlast_CBE
77.83
44%
-70
- C3 -
3N9S
5
?
B:
[2-306]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
-
G
---
I
D
M
A
V
G
M
V
K
-
I
M
C
E
R
-
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
------------
A
-
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
FK
F
K
---
G
--
E
--
P
K
L
D
F
E
R
L
Q
E
V
K
R
--
L
T
N
I
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
V
R
K
S
Y
L
D
A
GG
D
L
K
GS
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
--
11
PsiBlast_PDB
77.43
42%
-73
- C3 -
2ISW
2
?
A:
[2-307]
---
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
D
M
---
I
Y
-
L
K
K
L
C
E
A
A
L
-
E
K
-
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
-------------
V
-
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
--
Y
K
FKS-------
R
L
A
I
D
R
V
K
T
I
S
D
--
L
T
G
I
P
L
V
M
H
G
S
S
SVP
K
D
V
K
D
M
I
N
K
Y
GGKMPDAV
G
V
P
---------------------
I
---------------------
E
----------
S
I
V
--
H
A
I
G
E
---------
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
51
HHSearch
77.31
47%
-68
- C3 -
2ISW
2
?
A:
[2-307]
---
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
D
----
M
I
Y
L
K
K
L
C
E
A
A
--
L
E
K
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
-------------
V
-
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
--
Y
K
F--
K
S-----
R
L
A
I
D
R
V
K
T
I
S
D
--
L
T
G
I
P
L
V
M
H
G
S
S
SVP
K
D
V
K
D
M
I
N
K
Y
GGKMPDAV
G
V
P
---------------------
I
---------------------
E
----------
S
I
V
--
H
A
I
G
E
---------
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
42
Fugue
76.30
42%
-70
- C3 -
1GVF
11
KBAY_ECOLI
A:
[2-285]
SI
I
S
---
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
----
H
IA
L
E
E
I
Y
A
L
C
S
A
Y
S
T
T
Y
-
N
M
--
P
L
A
L
H
L
D
H
H
ES
L
D
D
I
R
R
K
V
H
A
-----------
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
S
------------A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
--
Y
S
---
K
--
T
--
P
K
I
D
F
Q
R
L
A
E
I
R
E
V
V--
D
V
P
L
V
L
H
G
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
----------
F
V
R
--
R
T
I
E
L
---------
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
-Q
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
S
37
PsiBlast_CBE
75.37
42%
-69
- C3 -
2ISV
2
?
B:
[2-307]
---
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
D
M
---
I
Y
-
L
K
K
L
C
E
A
A
L
-
E
K
-
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
----------
Q
N
--
T
V
-
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
--
Y
K
F--------
I
R
L
A
I
D
R
V
K
T
I
S
D
--
L
T
G
I
P
L
V
M
H
G
S
S
SVP
K
D
V
K
D
M
I
N
K
Y
GGKMPDAV
G
V
P
---------------------
I
---------------------
E
----------
S
I
V
--
H
A
I
G
E
---------
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-