@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2334: (2016-04-03 )
MTIGIDKINFYVPKYYVDMAKLAEARQVDPNKFLIGIGQTEMAVSPVNQDIVSMGANAAKDIITDEDKKKIGMVIVATESAVDAAKAAAVQIHNLLGIQPFARCFEMKEACYAATPAIQLAKDYLATRPNEKVLVIATDTARYGLNSGGEPTQGAGAVAMVIAHNPSILALNEDAVAYTEDVYDFWRPTGHKYPLVDGALSKDAYIRSFQQSWNEYAKRQGKSLADFASLCFHVPFTKMGKKALESIIDNADETTQERLRSGYEDAVDYNRYVGNIYTGSLYLSLISLLENRDLQAGETIGLFSYGSGSVGEFYSATLVEGYKDHLDQAAHKALLNNRTEVSVDAYETFFKRFDDVEFDEEQDAVHEDRHIFYLSNIENNVREYHRPE
Atome Classification :
(20 SA)
-.........10........20........30........40........50........60..--.--..--...70........80........90.....---------...--100..-------.....110.......120...--....--130.......140...---.---...150.......160.....--.-.--170.----......180......----..-.-190----------.------.---......200.......210.----...------...---220--------.------......230.......240-..-------------------------------------.....--------------------------------250----------------------..----......--------.260..-------------------------..-----..--------.270.......280.......290.--.-..--....300.......310.......320-----..-----.....330.......340.......350...------....360....------....370......-.380......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
T
I
G
I
D
K
I
N
F
Y
V
P
K
Y
Y
V
D
M
A
K
L
A
E
A
RQVDPN
K
F
L
I
G
IGQTEMAVSPV
N
Q
D
I
V
S
MG
A
N
A
A
K
D
II--T--DE--DKKKI
G
M
V
I
V
ATESAV
D
A
A
K
A
A
A
V
Q
I
H
N
LL---------G
I
Q
--
P
F
A
R
C
-------
F
E
M
K
E
A
C
YAA
T
P
A
I
Q
L
A
K
D
Y
L
--ATRP--N
E
K
V
L
V
I
ATDTARYGL---N---SGGEPTQGA
G
A
V
A
M
V
I
AHN
P
S
--
I
-
L
--
A
LNE----DA
V
A
Y
T
E
--
D
V
Y
D
F
W----RP-T-G-H----------K------Y---PLVDGALS
K
D
A
Y
I
R
S
F
Q
Q
S
W
----
N
E
Y
------
A
K
R---QGK--------
S
------
L
A
D
F
A
S
L
C
FHV
P
F
T
K
M
G
K
K
-
A
L
-------------------------------------
E
S
I
ID--------------------------------N------------------------A
D
----
E
T
T
Q
E
R
--------
L
R
SGYE-------------------------DA-----V
D
--------
Y
N
R
YVGNIYT
G
S
L
Y
L
S
L
I
S
L
L
EN-R--D-LQ--AG
E
T
I
G
L
F
SYGSGS
V
G
E
F
Y
S
A
T
L
V
E
G
Y
-----
K
D
-----
H
L
D
Q
A
A
H
K
A
L
LNNRT
E
V
S
V
D
A
Y
E
T
F
F
K
RFDD------VEFD
E
E
-QDAV------HED
R
H
I
F
Y
L
S
NIE-
N
N
V
R
E
YHRPE
1
PsiBlast_PDB
95.51
100%
-104
- C4 -
1XPK
3
?
C:
[2-388]
--
T
I
G
I
D
K
I
N
F
Y
V
P
K
Y
Y
V
D
M
A
K
L
A
E
A
R
Q
V
D
P
N
K
F
L
I
G
I
G
Q
T
E
M
A
V
S
P
V
N
Q
D
I
V
S
M
G
A
N
A
A
K
D
I
I
--
T
--
D
E
--
D
K
K
K
I
G
M
V
I
V
A
T
E
S
A
V
D
A
A
K
A
A
A
V
Q
I
H
N
L
L
---------
G
I
Q
--
P
F
A
R
C
-------
F
E
M
K
E
A
C
Y
A
A
T
P
A
I
Q
L
A
K
D
Y
L
--
A
T
R
P
--
N
E
K
V
L
V
I
A
T
D
T
A
R
Y
G
L
---
N
---
S
G
G
E
P
T
Q
G
A
G
A
V
A
M
V
I
A
H
N
P
S
--
I
-
L
--
A
L
N
E
----
D
A
V
A
Y
T
E
--
D
V
Y
D
F
W
----
R
P
-
T
-
G
-
H
----------
K
------
Y
---
P
L
V
D
G
A
L
S
K
D
A
Y
I
R
S
F
Q
Q
S
W
----
N
E
Y
------
A
K
R
---
Q
G
K
--------
S
------
L
A
D
F
A
S
L
C
F
H
V
P
F
T
K
M
G
K
K
-
A
L
-------------------------------------
E
S
I
I
D
--------------------------------
N
------------------------
A
D
----
E
T
T
Q
E
R
--------
L
R
S
G
Y
E
-------------------------
D
A
-----
V
D
--------
Y
N
R
Y
V
G
N
I
Y
T
G
S
L
Y
L
S
L
I
S
L
L
E
N
-
R
--
D
-
L
Q
--
A
G
E
T
I
G
L
F
S
Y
G
S
G
S
V
G
E
F
Y
S
A
T
L
V
E
G
Y
-----
K
D
-----
H
L
D
Q
A
A
H
K
A
L
L
N
N
R
T
E
V
S
V
D
A
Y
E
T
F
F
K
R
F
D
D
------
V
E
F
D
E
E
-
Q
D
A
V
------
H
E
D
R
H
I
F
Y
L
S
N
I
E
-
N
N
V
R
E
Y
H
R
P
E
61
Fugue
87.73
60%
-102
- C4 -
1X9E
2
HMGCS_ENTFL
A:
[1-383]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
V
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
--
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
---------
G
I
Q
--
P
F
A
R
S
-------
F
E
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
--
A
L
H
P
--
D
K
K
V
L
V
V
A
A
D
I
A
K
Y
G
L
---
N
---
S
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
A
S
E
P
R
--
I
-
L
--
A
L
K
E
----
D
N
V
M
L
T
Q
--
D
I
Y
D
F
W
----
R
P
-
T
-
G
-
H
----------
P
------
Y
---
P
M
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
----
D
E
H
------
K
K
R
---
T
G
L
--------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
-------------------------------------
L
A
K
I
S
--------------------------------
D
------------------------
Q
T
----
E
A
E
Q
E
R
--------
I
L
A
R
Y
E
-------------------------
E
S
-----
I
I
--------
Y
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
E
N
A
T
--
T
-
L
T
--
A
G
N
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
G
E
L
V
A
G
Y
-----
Q
N
-----
H
L
Q
K
E
T
H
L
A
L
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
F
A
E
----------
T
L
D
T
D
-
I
D
Q
T
------
L
E
D
E
L
K
Y
S
I
S
A
I
N
-
N
T
V
R
S
Y
R
N
--
24
PsiBlast_CBE
87.40
59%
-103
- C4 -
3V4X
2
HMGCS_ENTFL
B:
[6-386]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
V
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
--
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
---------
G
I
Q
--
P
F
A
R
S
-------
F
E
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
--
A
L
H
P
--
D
K
K
V
L
V
V
A
A
D
I
A
K
Y
G
L
---
N
---
S
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
S
S
E
P
R
--
I
-
L
--
A
L
K
E
----
D
N
V
M
L
T
Q
--
D
I
Y
D
F
W
----
R
P
-
T
-
G
-
H
----------
P
------
Y
---
P
M
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
----
D
E
H
------
K
K
R
---
T
G
L
--------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
-------------------------------------
L
A
K
I
S
--------------------------------
D
------------------------
Q
T
----
E
A
E
Q
E
R
--------
I
L
A
R
Y
E
-------------------------
E
S
-----
I
I
--------
Y
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
E
N
A
T
--
T
-
L
T
--
A
G
N
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
G
E
L
V
A
G
Y
-----
Q
N
-----
H
L
Q
K
E
T
H
L
A
L
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
F
A
E
T
L
D
------
T
D
I
D
Q
-----
T
------
L
E
D
E
L
K
Y
S
I
S
A
I
N
-
N
T
V
R
S
Y
----
25
PsiBlast_CBE
87.18
59%
-102
- C4 -
2HDB
3
HMGCS_ENTFL
B:
[1-381]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
V
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
--
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
---------
G
I
Q
--
P
F
A
R
S
-------
F
E
I
K
E
G
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
--
A
L
H
P
--
D
K
K
V
L
V
V
A
A
D
I
A
K
Y
G
L
---
N
---
S
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
A
S
E
P
R
--
I
-
L
--
A
L
K
E
----
D
N
V
M
L
T
Q
--
D
I
Y
D
F
W
----
R
P
-
T
-
G
-
H
----------
P
------
Y
---
P
M
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
----
D
E
H
------
K
K
R
---
T
G
L
--------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
-------------------------------------
L
A
K
I
S
--------------------------------
D
------------------------
Q
T
----
E
A
E
Q
E
R
--------
I
L
A
R
Y
E
-------------------------
E
S
-----
I
I
--------
Y
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
E
N
A
T
--
T
-
L
T
--
A
G
N
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
G
E
L
V
A
G
Y
-----
Q
N
-----
H
L
Q
K
E
T
H
L
A
L
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
F
A
E
T
L
D
------
T
D
I
D
Q
-----
T
------
L
E
D
E
L
K
Y
S
I
S
A
I
N
-
N
T
V
R
S
Y
----
23
PsiBlast_CBE
86.99
59%
-101
- C4 -
3V4X
1
HMGCS_ENTFL
C:
[6-386]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
V
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
--
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
---------
G
I
Q
--
P
F
A
R
S
-------
F
E
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
--
A
L
H
P
--
D
K
K
V
L
V
V
A
A
D
I
A
K
Y
G
L
---
N
---
S
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
S
S
E
P
R
--
I
-
L
--
A
L
K
E
----
D
N
V
M
L
T
Q
--
D
I
Y
D
F
W
----
R
P
-
T
-
G
-
H
----------
P
------
Y
---
P
M
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
----
D
E
H
------
K
K
R
---
T
G
L
--------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
-------------------------------------
L
A
K
I
S
--------------------------------
D
------------------------
Q
T
----
E
A
E
Q
E
R
--------
I
L
A
R
Y
E
-------------------------
E
S
-----
I
I
--------
Y
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
E
N
A
T
--
T
-
L
T
--
A
G
N
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
G
E
L
V
A
G
Y
-----
Q
N
-----
H
L
Q
K
E
T
H
L
A
L
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
F
A
E
T
L
D
------
T
D
I
D
Q
-----
T
------
L
E
D
E
L
K
Y
S
I
S
A
I
N
-
N
T
V
R
S
Y
----
2
PsiBlast_PDB
86.76
59%
-101
- C4 -
1X9E
2
HMGCS_ENTFL
A:
[1-381]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
V
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
--
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
---------
G
I
Q
--
P
F
A
R
S
-------
F
E
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
--
A
L
H
P
--
D
K
K
V
L
V
V
A
A
D
I
A
K
Y
G
L
---
N
---
S
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
A
S
E
P
R
--
I
-
L
--
A
L
K
E
----
D
N
V
M
L
T
Q
--
D
I
Y
D
F
W
----
R
P
-
T
-
G
-
H
----------
P
------
Y
---
P
M
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
----
D
E
H
------
K
K
R
---
T
G
L
--------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
-------------------------------------
L
A
K
I
S
--------------------------------
D
------------------------
Q
T
----
E
A
E
Q
E
R
--------
I
L
A
R
Y
E
-------------------------
E
S
-----
I
I
--------
Y
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
E
N
A
T
--
T
-
L
T
--
A
G
N
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
G
E
L
V
A
G
Y
-----
Q
N
-----
H
L
Q
K
E
T
H
L
A
L
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
F
A
E
T
L
D
------
T
D
I
D
Q
-----
T
------
L
E
D
E
L
K
Y
S
I
S
A
I
N
-
N
T
V
R
S
Y
----
3
PsiBlast_PDB
86.71
59%
-102
- C4 -
3V4X
2
HMGCS_ENTFL
A:
[6-386]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
V
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
--
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
---------
G
I
Q
--
P
F
A
R
S
-------
F
E
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
--
A
L
H
P
--
D
K
K
V
L
V
V
A
A
D
I
A
K
Y
G
L
---
N
---
S
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
S
S
E
P
R
--
I
-
L
--
A
L
K
E
----
D
N
V
M
L
T
Q
--
D
I
Y
D
F
W
----
R
P
-
T
-
G
-
H
----------
P
------
Y
---
P
M
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
----
D
E
H
------
K
K
R
---
T
G
L
--------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
-------------------------------------
L
A
K
I
S
--------------------------------
D
------------------------
Q
T
----
E
A
E
Q
E
R
--------
I
L
A
R
Y
E
-------------------------
E
S
-----
I
I
--------
Y
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
E
N
A
T
--
T
-
L
T
--
A
G
N
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
G
E
L
V
A
G
Y
-----
Q
N
-----
H
L
Q
K
E
T
H
L
A
L
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
F
A
E
T
L
D
------
T
D
I
D
Q
-----
T
------
L
E
D
E
L
K
Y
S
I
S
A
I
N
-
N
T
V
R
S
Y
----
4
PsiBlast_PDB
86.60
59%
-101
- C4 -
2HDB
2
HMGCS_ENTFL
A:
[1-381]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
V
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
--
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
---------
G
I
Q
--
P
F
A
R
S
-------
F
E
I
K
E
G
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
--
A
L
H
P
--
D
K
K
V
L
V
V
A
A
D
I
A
K
Y
G
L
---
N
---
S
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
A
S
E
P
R
--
I
-
L
--
A
L
K
E
----
D
N
V
M
L
T
Q
--
D
I
Y
D
F
W
----
R
P
-
T
-
G
-
H
----------
P
------
Y
---
P
M
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
----
D
E
H
------
K
K
R
---
T
G
L
--------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
-------------------------------------
L
A
K
I
S
--------------------------------
D
------------------------
Q
T
----
E
A
E
Q
E
R
--------
I
L
A
R
Y
E
-------------------------
E
S
-----
I
I
--------
Y
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
E
N
A
T
--
T
-
L
T
--
A
G
N
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
G
E
L
V
A
G
Y
-----
Q
N
-----
H
L
Q
K
E
T
H
L
A
L
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
F
A
E
T
L
D
------
T
D
I
D
Q
-----
T
------
L
E
D
E
L
K
Y
S
I
S
A
I
N
-
N
T
V
R
S
Y
----
22
PsiBlast_CBE
86.47
59%
-102
- C4 -
3V4X
1
HMGCS_ENTFL
D:
[6-386]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
V
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
--
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
---------
G
I
Q
--
P
F
A
R
S
-------
F
E
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
--
A
L
H
P
--
D
K
K
V
L
V
V
A
A
D
I
A
K
Y
G
L
---
N
---
S
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
S
S
E
P
R
--
I
-
L
--
A
L
K
E
----
D
N
V
M
L
T
Q
--
D
I
Y
D
F
W
----
R
P
-
T
-
G
-
H
----------
P
------
Y
---
P
M
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
----
D
E
H
------
K
K
R
---
T
G
L
--------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
-------------------------------------
L
A
K
I
S
--------------------------------
D
------------------------
Q
T
----
E
A
E
Q
E
R
--------
I
L
A
R
Y
E
-------------------------
E
S
-----
I
I
--------
Y
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
E
N
A
T
--
T
-
L
T
--
A
G
N
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
G
E
L
V
A
G
Y
-----
Q
N
-----
H
L
Q
K
E
T
H
L
A
L
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
F
A
E
T
L
D
------
T
D
I
D
Q
-----
T
------
L
E
D
E
L
K
Y
S
I
S
A
I
N
-
N
T
V
R
S
Y
----
21
PsiBlast_CBE
85.99
59%
-100
- C4 -
1X9E
2
HMGCS_ENTFL
B:
[1-381]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
V
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
--
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
---------
G
I
Q
--
P
F
A
R
S
-------
F
E
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
--
A
L
H
P
--
D
K
K
V
L
V
V
A
A
D
I
A
K
Y
G
L
---
N
---
S
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
A
S
E
P
R
--
I
-
L
--
A
L
K
E
----
D
N
V
M
L
T
Q
--
D
I
Y
D
F
W
----
R
P
-
T
-
G
-
H
----------
P
------
Y
---
P
M
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
----
D
E
H
------
K
K
R
---
T
G
L
--------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
-------------------------------------
L
A
K
I
S
--------------------------------
D
------------------------
Q
T
----
E
A
E
Q
E
R
--------
I
L
A
R
Y
E
-------------------------
E
S
-----
I
I
--------
Y
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
E
N
A
T
--
T
-
L
T
--
A
G
N
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
G
E
L
V
A
G
Y
-----
Q
N
-----
H
L
Q
K
E
T
H
L
A
L
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
F
A
E
T
L
D
------
T
D
I
D
Q
-----
T
------
L
E
D
E
L
K
Y
S
I
S
A
I
N
-
N
T
V
R
S
Y
----
5
PsiBlast_PDB
85.66
59%
-103
- C4 -
1YSL
4
HMGCS_ENTFL
B:
[20-400]
-
M
T
I
G
I
D
K
I
S
F
F
V
P
P
Y
Y
I
D
M
T
A
L
A
E
A
R
N
V
D
P
G
K
F
H
I
G
I
G
Q
D
Q
M
A
V
N
P
I
S
Q
D
I
V
T
F
A
A
N
A
A
E
A
I
L
--
T
--
K
E
--
D
K
E
A
I
D
M
V
I
V
G
T
E
S
S
I
D
E
S
K
A
A
A
V
V
L
H
R
L
M
---------
G
I
Q
--
P
F
A
R
S
-------
F
E
I
K
E
A
C
Y
G
A
T
A
G
L
Q
L
A
K
N
H
V
--
A
L
H
P
--
D
K
K
V
L
V
V
A
A
D
I
A
K
Y
G
L
---
N
---
S
G
G
E
P
T
Q
G
A
G
A
V
A
M
L
V
A
S
E
P
R
--
I
-
L
--
A
L
K
E
----
D
N
V
M
L
T
Q
--
D
I
Y
D
F
W
----
R
P
-
T
-
G
-
H
----------
P
------
Y
---
P
M
V
D
G
P
L
S
N
E
T
Y
I
Q
S
F
A
Q
V
W
----
D
E
H
------
K
K
R
---
T
G
L
--------
D
------
F
A
D
Y
D
A
L
A
F
H
I
P
Y
T
K
M
G
K
K
-
A
L
-------------------------------------
L
A
K
I
S
--------------------------------
D
------------------------
Q
T
----
E
A
E
Q
E
R
--------
I
L
A
R
Y
E
-------------------------
E
S
-----
I
I
--------
Y
S
R
R
V
G
N
L
Y
T
G
S
L
Y
L
G
L
I
S
L
L
E
N
A
T
--
T
-
L
T
--
A
G
N
Q
I
G
L
F
S
Y
G
S
G
A
V
A
E
F
F
T
G
E
L
V
A
G
Y
-----
Q
N
-----
H
L
Q
K
E
T
H
L
A
L
L
D
N
R
T
E
L
S
I
A
E
Y
E
A
M
F
A
E
T
L
D
------
T
D
I
D
Q
-----
T
------
L
E
D
E
L
K
Y
S
I
S
A
I
N
-
N
T
V
R
S
Y
----
7
PsiBlast_PDB
68.37
29%
-91
- C4 -
2F82
-
?
A:
[5-372]
---
V
G
I
L
A
M
D
I
Y
F
P
P
T
C
V
Q
Q
E
A
L
E
A
H
D
G
A
S
K
G
K
Y
T
I
G
L
G
Q
D
C
L
A
F
C
T
E
L
E
D
V
I
S
M
S
F
N
A
V
T
S
L
L
--
E
--
K
Y
KI
D
P
K
Q
I
G
R
L
E
V
G
S
E
T
V
I
D
K
S
K
S
----
I
K
T
F
L
----------
M
Q
--
L
F
E
K
C
GNTD
V
E
G
V
D
S
T
N
A
C
Y
G
G
T
A
A
L
L
N
C
V
N
W
V
--
E
S
N
S
WD
G
R
Y
G
L
V
I
C
T
D
S
A
V
Y
A
----
E
---
G
P
A
R
P
T
G
G
A
A
A
I
A
M
L
I
G
P
D
A
P
--
I
-
V
--
F
E
S
K
----
L
R
G
S
H
M
A
--
H
V
Y
D
F
Y
----
K
P
-
N
L
A
-
S
----------
E
------
Y
---
P
V
V
D
G
K
L
S
Q
T
C
Y
L
M
A
L
D
S
C
Y
K
H
L
C
N
K
F
------
E
K
L
---
E
G
K
E
F
------
S
------
I
N
D
A
D
Y
F
V
F
H
S
P
Y
N
K
L
V
Q
K
-
S
F
-------------------------------------
A
R
L
L
Y
--------------------------------
N
D
F
L
R
NASSID
E
A
A
K
E
K
F
TPYSSLS
L
D
----
E
S
Y
Q
S
R
D
L
E
K
V
S
Q
Q
L
A
K
T
Y
Y
-------------------------
D
A
KVQPT
T
L
--------
V
P
K
Q
V
G
N
M
Y
T
A
S
L
Y
A
A
F
A
S
L
V
H
N
-
K
HS
D
-
L
---
A
G
K
R
V
V
M
F
S
Y
G
S
G
S
T
A
T
M
F
S
L
R
L
C
E
--------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.14
29%
-94
- C4 -
2FA0
1
?
A:
[4-371]
---
V
G
I
L
A
M
D
I
Y
F
P
P
T
C
V
Q
Q
E
A
L
E
A
H
D
G
A
S
K
G
K
Y
T
I
G
L
G
Q
D
C
L
A
F
C
T
E
L
E
D
V
I
S
M
S
F
N
A
V
T
S
L
L
--
E
--
K
Y
KI
D
P
K
Q
I
G
R
L
E
V
G
S
E
T
V
I
D
K
S
K
S
----
I
K
T
F
L
----------
M
Q
--
L
F
E
K
C
GNTD
V
E
G
V
D
S
T
N
A
C
Y
G
G
T
A
A
L
L
N
C
V
N
W
V
--
E
S
N
S
WD
G
R
Y
G
L
V
I
C
T
D
S
A
V
Y
A
----
E
---
G
P
A
R
P
T
G
G
A
A
A
I
A
M
L
I
G
P
D
A
P
--
I
-
V
--
F
E
S
K
----
L
R
G
S
H
M
A
--
H
V
Y
D
F
Y
----
K
P
-
N
L
A
-
S
----------
E
------
Y
---
P
V
V
D
G
K
L
S
Q
T
C
Y
L
M
A
L
D
S
C
Y
K
H
L
C
N
K
F
------
E
K
L
---
E
G
K
E
F
------
S
------
I
N
D
A
D
Y
F
V
F
H
S
P
Y
N
K
L
V
Q
K
-
S
F
-------------------------------------
A
R
L
L
Y
--------------------------------
N
D
F
L
R
NASSID
E
A
A
K
E
K
F
TPYSSLS
L
D
----
E
S
Y
Q
S
R
D
L
E
K
V
S
Q
Q
L
A
K
T
Y
Y
-------------------------
D
A
KVQPT
T
L
--------
V
P
K
Q
V
G
N
M
Y
T
A
S
L
Y
A
A
F
A
S
L
V
H
N
-
K
HS
D
-
L
---
A
G
K
R
V
V
M
F
S
Y
G
S
G
S
T
A
T
M
F
S
L
R
L
C
E
--------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.06
29%
-93
- C4 -
2WYA
1
HMCS2_HUMAN
A:
[6-374]
---
V
G
I
L
A
L
E
V
Y
F
P
A
Q
Y
V
D
Q
T
D
L
E
K
Y
N
N
V
E
A
G
K
Y
T
V
G
L
G
Q
T
R
M
G
F
C
S
V
Q
E
D
I
N
S
L
C
L
T
V
V
Q
R
L
M
E
R
I
--
Q
L
--
P
W
D
S
V
G
R
L
E
V
G
T
E
T
I
I
D
K
S
K
A
V
K
T
V
L
M
E
L
F
QDSGNTD
I
E
G
I
----------------
D
T
T
N
A
C
Y
G
G
T
A
S
L
F
N
A
A
N
W
M
E
S
S
S
W
D
--
G
R
Y
A
M
V
V
C
G
D
I
A
V
Y
P
----
S
---
G
N
A
R
P
T
G
G
A
G
A
V
A
M
L
I
G
P
K
A
P
--
L
-
A
--
L
E
R
G
----
L
R
G
T
H
M
E
--
N
V
Y
D
F
Y
----
K
P
-
N
L
A
-
S
----------
E
------
Y
---
P
I
V
D
G
K
L
S
I
Q
C
Y
L
R
A
L
D
R
C
Y
----
T
S
Y
------
R
K
K
I
Q
N
Q
W
K
Q
A
GSD
R
P
F
T
------
L
D
D
L
Q
Y
M
I
F
H
T
P
F
C
K
M
V
Q
K
-
S
L
-------------------------------------
A
R
L
M
F
--------------------------------
N
D
F
L
S
--------------------
A
S
----
S
D
T
Q
T
S
--------
L
Y
K
G
L
E
AFGGLKLEDTYTN
K
D
L
D
K
A
L
L
K
A
S
Q
D
M
-----
F
D
K
KTKASL
Y
L
S
T
H
N
G
N
M
Y
T
S
S
L
Y
G
C
L
A
S
L
L
S
H
-
H
--
S
-
A
Q
EL
A
G
S
R
I
G
A
F
S
Y
G
S
G
L
A
A
S
F
F
S
-------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.08
29%
-97
- C4 -
2F9A
1
?
A:
[4-371]
---
V
G
I
L
A
M
D
I
Y
F
P
P
T
C
V
Q
Q
E
A
L
E
A
H
D
G
A
S
K
G
K
Y
T
I
G
L
G
Q
D
C
L
A
F
C
T
E
L
E
D
V
I
S
M
S
F
N
A
V
T
S
L
L
--
E
--
K
Y
KI
D
P
K
Q
I
G
R
L
E
V
G
S
E
T
V
I
D
K
S
K
S
----
I
K
T
F
L
----------
M
Q
--
L
F
E
K
C
GNTD
V
E
G
V
D
S
T
N
A
C
Y
G
G
T
A
A
L
L
N
C
V
N
W
V
--
E
S
N
S
WD
G
R
Y
G
L
V
I
C
T
D
S
A
V
Y
A
----
E
---
G
P
A
R
P
T
G
G
A
A
A
I
A
M
L
I
G
P
D
A
P
--
I
-
V
--
F
E
S
K
----
L
R
G
S
H
M
A
--
H
V
Y
D
F
Y
----
K
P
-
N
L
A
-
S
----------
E
------
Y
---
P
V
V
D
G
K
L
S
Q
T
C
Y
L
M
A
L
D
S
C
Y
K
H
L
C
N
K
F
------
E
K
L
---
E
G
K
E
F
------
S
------
I
N
D
A
D
Y
F
V
F
H
S
P
Y
N
K
L
V
Q
K
-
S
F
-------------------------------------
A
R
L
L
Y
----------------------------------------------------------------------------------
Y
-------------------------
D
A
KVQPT
T
L
--------
V
P
K
Q
V
G
N
M
Y
T
A
S
L
Y
A
A
F
A
S
L
V
H
N
-
K
HS
D
-
L
---
A
G
K
R
V
V
M
F
S
Y
G
S
G
S
T
A
T
M
F
S
L
R
L
C
E
--------------------------------------------------------------------------------------------
62
Fugue
64.64
25%
-78
- C4 -
2F82
-
?
A:
[2-451]
A
K
N
V
G
I
L
A
M
D
I
Y
F
P
P
T
C
V
Q
Q
E
A
L
E
A
H
D
G
A
S
K
G
K
Y
T
I
G
L
G
Q
D
C
L
A
F
C
T
E
L
E
D
V
I
S
M
S
F
N
A
V
T
S
L
L
--
E
--
K
Y
KI
D
P
K
Q
I
G
R
L
E
V
G
S
E
T
V
I
D
K
S
K
S
I
K
T
F
L
M
Q
L
F
---------
E
K
C
GN
T
D
V
E
G
-------
V
D
S
T
N
A
C
Y
G
G
T
A
A
L
L
N
C
V
N
W
V
--
E
S
N
S
WD
G
R
Y
G
L
V
I
C
T
D
S
A
V
Y
-
A
---
E
---
G
P
A
R
P
T
G
G
A
A
A
I
A
M
L
I
G
P
D
A
P
--
I
-
V
--
F
E
S
K
----
L
R
G
S
H
M
A
--
H
V
Y
D
F
Y
----
K
P
N
L
-
A
-
S
----------
E
------
Y
---
P
V
V
D
G
K
L
S
Q
T
C
Y
L
M
A
L
D
S
C
Y
----
K
H
L
------
C
N
K
---
F
E
K
--------
L
EG
K
E
F
S
I
N
D
A
D
Y
F
V
F
H
S
P
Y
N
K
L
V
Q
K
-
S
F
A
R
L
L
Y
N
D
F
L
R
NASSID
E
A
A
K
E
K
F
TPYSSLS
L
D
E
S
Y
Q
S
R
D
L
E
K
--------------------------------
V
------------------------
S
Q
----
Q
L
A
K
T
Y
--------
Y
D
A
K
V
Q
-------------------------
P
T
-----
T
L
--------
V
P
K
Q
V
G
N
M
Y
T
A
S
L
Y
A
A
F
A
S
L
V
H
N
-
K
--
H
-
S
D
L-
A
G
K
R
V
V
M
F
S
Y
G
S
G
S
T
A
T
M
F
S
L
R
L
C
E
N
Q
S
PFS
L
S
N
-----
I
A
S
V
M
D
V
G
G
K
L
K
A
R
H
E
Y
A
P
E
K
F
V
E
T
M
K
L
M
E
H
R
YGA
K
E
F
V
T
S
K
E
-
G
I
L
D
------
L
L
A
P
G
T
Y
Y
L
K
E
V
D
-
S
L
Y
R
R
F
Y
G
K
K
30
HHSearch
63.34
25%
-74
- C4 -
2F82
-
?
A:
[3-451]
-
K
N
V
G
I
L
A
M
D
I
Y
F
P
P
T
C
V
Q
Q
E
A
L
E
A
H
D
G
A
S
K
G
K
Y
T
I
G
L
G
Q
D
C
L
A
F
C
T
E
L
E
D
V
I
S
M
S
F
N
A
V
T
S
L
L
--
E
K
Y
K
I
--
D
P
K
Q
I
G
R
L
E
V
G
S
E
T
V
I
D
K
S
K
S
I
K
T
F
L
M
Q
L
F
---------
E
K
C
GN
T
D
V
E
G
-------
V
D
S
T
N
A
C
Y
G
G
T
A
A
L
L
N
C
V
N
W
V
--
E
S
N
S
WD
G
R
Y
G
L
V
I
C
T
D
S
A
V
Y
A
E
---
G
----
P
A
R
P
T
G
G
A
A
A
I
A
M
L
I
G
P
D
A
P
----
I
--
V
F
E
S
K---
L
R
G
S
H
M
A
--
H
V
Y
D
F
Y
----
K
P
-
N
-
L
A
S
----------
E
------
Y
---
P
V
V
D
G
K
L
S
Q
T
C
Y
L
M
A
L
D
S
C
Y
----
K
H
L
C
N
K
F
E
K
L
E
G
---
K
E
F
--------
S
------
I
N
D
A
D
Y
F
V
F
H
S
P
Y
N
K
L
V
Q
K
S
F
A
-------------------------------------
R
L
L
Y
N
D
F
L
R
NASSID
E
A
A
K
E
K
F
TPYSSLS
L
D
E
S
Y
Q
S
R
D
------------------------
L
E
K
V
S
Q
Q
L
A
K
T
Y
--------
Y
D
A
K
V
Q
-------------------------
P
T
-----
T
L
--------
V
P
K
Q
V
G
N
M
Y
T
A
S
L
Y
A
A
F
A
S
L
V
H
N
-
K
--
H
S
D
L
--
A
G
K
R
V
V
M
F
S
Y
G
S
G
S
T
A
T
M
F
S
L
R
L
C
E
N
Q
-----
S
P
FS
L
S
N
I
A
S
V
M
D
V
G
G
K
L
K
A
R
H
E
Y
A
P
E
K
F
V
E
T
M
K
L
M
E
H
------
R
Y
G
A
-
K
E
F
V
T
S
KEGILD
L
L
A
P
G
T
Y
Y
L
K
E
V
D
S
L
Y
R
R
F
Y
G
K
K
-
35
HHSearch
58.96
17%
-82
* C4 *
2X3E
-
FABH_PSEAE
A:
[3-327]
-
R
A
A
V
V
C
G
L
G
S
Y
L
P
E
A
V
L
S
N
D
M
L
A
A
E
L
D
T
S
D
A
W
I
S
S
R
T
G
V
R
Q
R
H
I
A
G
-
D
L
G
S
G
D
L
A
L
R
A
A
S
A
A
L
--
A
S
A
G
L
----
E
R
V
D
A
V
V
L
A
T
S
T
G
D
F
C
C
P
A
T
A
P
R
V
A
A
R
L
---------
G
L
V
---
G
A
L
A
-------
F
D
L
S
A
A
A
T
G
F
V
Y
G
L
A
S
V
G
S
L
I
--
S
A
G
L
--
A
D
S
A
L
L
V
G
V
D
T
F
S
H
T
L
---
D
PAD
R
S
T
R
A
L
F
G
D
G
A
G
A
V
V
L
R
A
G
D
A
EE
E
-
G
--
A
L
L
A
F
D
L
G
S
D
G
H
Q
F
D
-----
L
L
M
----
T
P
-
A
-
V
-
S
R
A
E
R
S
S
GQAS
N
------
Y
---
F
R
M
D
G
K
A
V
F
G
Q
A
V
T
Q
M
S
D
S
V
----
R
R
V
------
L
D
R
---
V
G
W
--------
Q
------
A
S
D
L
H
H
L
V
P
H
Q
A
N
T
R
I
L
A
A
-
V
A
-------------------------------------
D
Q
L
D
L
--------------------------------
P
------------------------
V
---------------------
E
R
V
V
-------------------------
S
----------------
N
I
A
E
V
G
N
T
V
A
A
S
I
P
L
A
L
A
H
G
L
R
Q
-
G
--
I
-
L
R
--
D
G
G
N
M
V
L
T
G
F
G
A
G
L
T
W
G
S
V
A
L
R
W
P
K
I
V
-----
P
------------------------------------------------------------------------------------
38
HHSearch
58.64
17%
-79
- C4 -
1UB7
4
?
A:
[2-321]
---
S
G
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
E
A
Y
L
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
E
D
E
Y
T
S
D
L
A
F
K
A
V
E
D
L
L
--
R
R
H
P
G
--
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
---------
G
L
K
----
A
F
A
-------
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
--
E
A
G
L
--
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
---
D
WND
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
--
G
-
Y
--
G
F
R
S
F
V
L
G
A
D
G
T
G
A
K
--
E
L
Y
H
A
C
VAPR
L
P
-
D
-
G
-
T
----------
S
------
M
K
N
R
L
Y
M
N
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
----
L
E
A
------
I
E
K
---
A
G
L
--------
T
------
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
-
A
R
-------------------------------------
E
R
L
G
L
--------------------------------
P
------------------------
W
---------------------
E
R
V
A
-------------------------
V
----------------
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
D
A
-
G
--
R
-
I
R
--
E
G
D
H
V
L
L
V
S
F
G
A
G
L
T
W
A
A
A
V
L
T
W
G
G
--------------------------------------------------------------------------------------------
43
HHSearch
57.52
17%
-87
- C4 -
1MZJ
2
FABH_STRLI
A:
[11-335]
--
F
S
R
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
I
D
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
P
D
E
T
I
Q
V
M
G
V
A
A
S
R
R
A
L
--
E
H
A
G
V
--
D
P
A
E
I
D
L
V
V
V
S
T
M
T
N
F
V
H
T
P
P
L
S
V
A
I
A
H
E
L
---------
G
A
D
---
N
A
G
G
-------
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
--
E
S
G
G
--
S
R
H
V
L
V
V
A
T
E
R
M
T
D
V
I
DLA
D
---
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
S
D
V
--
P
G
I
G
P
V
V
R
G
----
I
D
G
T
G
L
G
SL
H
M
S
S
S
W
----
D
Q
-
Y
-
V
-
E
----------
D
PSVGR
P
A
---
L
V
M
D
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
----
R
E
A
------
L
E
V
---
A
G
L
--------
T
------
V
G
D
L
V
A
F
V
P
H
Q
A
N
L
R
I
I
D
V
-
L
V
-------------------------------------
D
R
L
G
V
--------------------------------
P
------------------------
E
---------------------
H
V
V
V
-------------------------
S
R
---------------
D
A
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
R
L
V
R
S
-
G
--
A
-
V
P
--
G
G
G
P
A
L
M
I
G
F
G
A
G
L
S
Y
A
G
Q
A
L
L
L
P
D
P
P
------------------------------------------------------------------------------------------