@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0054: (2015-12-12 )
MLSIGGLVDDASLTKFENPTIVEFRHIKKFITEYNALDHRPFTEKNDIEVAHEAQKNAAIVKGNDLYRFFSKLKQWAGADEKQNFRDLEEDFSLESFTHCTDFNPIEIYAYCISRSINNMENGVFLKYFLSYPIKYEKHQAEKIRESFERGLKKSLPRHVFDDEKTAKTFKVELRASEPCAYAISALKSYGFFKSEKLDKPVYYGVFDFGGGTTDFDFGKWEKRASPKFAYKMTHFSSGGDKYLGGENLLELLAWETYAKNFQTLKEKDIVIAKPNYDRIDTQLFGSFMQNSSGVRLNLQTIASQLRPFLENLDANIIEAIEENENFEIKGFEKDFKAMLFDRNGVETECDLKVDCKELLNLLKGKIEDGVANFFAGFSKVMAENIDDQCRAFHIFLGRNVSRSALVKQAFENAKEKQLKDYHQKTSKNDFKFIIYEPLGTEKSDKQILELTGEDVSNTPAYLKPTCKTGVAFGLLESRDKAQGIEMPSISSNPVFKYDLGIEIEGKFHAKIHRDSLKPNEY
Atome Classification :
(20 SA)
-------------------------------------------------------.........10........20........30........40........50........60........70........80.....--..-.-90..-----------.-----------.------------.....-------100.......110-........120---....----------------------------...130-........-----140--.....----...150.........160.......170---.-......180.......190.....---..200.......210---....-----....220.......230....-...240.-------...--...250.......260.......270.......280......-.290........300....-...310.......320.-------..--..-..330..--.....340-.-......350.......360.-----......-370.......380--.....--..390.......400....-..--.410.......420.......430--....----.-----...440.......450...-----....460.......470--.........480..-.....490.......500.------....---..510.......520
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------MLSIGGLVDDASLTKFENPT
I
V
E
F
R
H
I
K
K
F
I
T
E
YNALDHRPFTEKND
I
E
V
A
H
EAQK
N
A
A
I
VKGN
D
L
Y
R
F
F
S
K
L
K
Q
W
AGAD
E
K
Q
N
F
R
--
D
L
-
E
-
E
-DF-----------S-----------L------------ESFTH-------CTDF
N
P
I
E
I
Y
A
Y
--
C
I
S
R
S
INNMEN---
G
V
F
L
----------------------------
K
Y
F
L
S--YPIKYEK
H
-----
Q
A
---
E
K
I
R
E
----
S
F
E
R
--
G
L
K
K
SL
P
R
H
VFDDEKT
A
K
T
F
K
V
---
E
-
L
RASE
P
C
A
Y
A
I
S
A
L
K
SYGFFKSEK---LDK
P
V
Y
Y
G
V
F
DFGG----GTTD-----FDFG
K
W
EKRASP
K
F
A
Y
K
MTHF-SSGGDKY-------L
G
G
--
E
N
L
L
E
L
L
A
W
E
T
Y
A
K
N
F
Q
T
LKEK
D
I
V
I
AKP
N
Y
D
R
I
D
T
Q
L
F
G
S
F
-
M
QN-SSG
V
R
L
N
L
Q
T
I
A
S
Q
L
-
R
P
F
L
E
NL
D
A
N
I
I
E
A
I
EE-------NE--
N
F
-
E
I
KG
F
E
K
--
D
F
K
A
M
L
FD-R-NGVETEC
D
L
KV
D
C
K
E
L
L
N
L
L
-----
K
G
K
I
E
D
-
G
V
A
N
F
F
A
G
F
S
K
V
M
--
A
ENI
D
--
D
Q
C
R
A
F
H
I
F
LGRNV
S
R
S
A
L
-
V
K
--
Q
A
F
E
N
A
K
E
K
Q
L
K
D
Y
H
Q
KTSKN
D
F
---
K
F
I
I
----
Y
-----EPLGTEKS
D
K
Q
I
L
E
LTGED-----VSNTP
A
Y
LKPTCKT
G
----
V
A
F
G
L
LESRDKAQG-IEMPSISSN
P
V
F
K
Y
D
L
G
I
E
------
I
E
G
K
---
F
H
A
K
I
HRDSLKPNEY
70
HHSearch
74.28
16%
-39
- C9 -
3I33
3
HSP72_HUMAN
A:
[30-376]
----------------------------------------------------------
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
-----
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
----
N
T
I
F
D
A
K
R
L
I
G
R
K
F
E
D
A
T
V
Q
S
D
M
-
K
H
W
-
P
F
R
V
V
S
E
GG
K
P
K
V
Q
-----------
V
------------
E
Y
K
G
E
-------
T
K
T
F
F
P
E
E
I
S
S
M
--
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
----------------------------
S
A
V
I
T
--
V
P
A
Y
F
N
D
S
-----
Q
R
---
Q
A
T
K
D
----
A
G
T
-------------------
I
T
G
L
N
V
---
L
-
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
G
C
-------
A
G
G
E
K
N
V
L
I
F
D
L
G
G
----
G
T
F
D
-----
V
S
I
L
T
I
E
-------
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
-------
L
G
G
--
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
K
H
---
K
K
D
I
--
G
------------------------
P
N
K
R
A
V
R
R
L
-
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
-------------------------
Q
A
S
I
E
I
D
S
L
Y
-
E
G
V
D
--
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
-----
A
D
L
F
R
G
-
T
L
E
----
P
V
E
K
A
L
--
R
D
A
K
L
--
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
-
I
Q
--
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
---
Y
G
A
A
----
V
-----
Q
A
A
I
L
I
---------------------------------------------------------------------------------------------------
69
HHSearch
73.23
17%
-31
* C9 *
3QFU
3
GRP78_YEAST
A:
[24-369]
---------------------------------------------------------
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
-----
F
T
D
-
D
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
----
N
T
I
F
D
I
K
R
L
I
G
L
K
Y
N
D
R
S
V
Q
K
D
I
-
K
-
H
L
P
F
-----------
N
V
V
N
K
DG
K
P
A
V
E
V
------------
S
V
K
G
E
-------
K
K
V
F
T
P
E
E
I
S
G
M
--
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
----------------------------
H
A
V
V
T
--
V
P
A
Y
F
N
D
A
-----
Q
R
---
Q
A
T
K
D
----
A
-------
G
T
------------
I
A
G
L
N
V
---
L
-
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
S
----------
D
K
E
H
Q
I
I
V
Y
D
L
G
G
----
G
T
F
D
-----
V
S
L
L
S
I
E
-------
N
G
V
F
E
V
Q
-
A
T
S
G
D
T
H
-------
L
G
G
--
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
H
---
G
I
D
V
S
--------------------------
D
N
N
K
A
L
A
K
L
-
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
M
S
---------------------
T
--
R
I
E
I
D
S
F
--
V
-
D
G
I
--
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
-----
L
D
L
F
K
K
-
T
L
K
----
P
V
E
K
V
L
--
Q
D
S
G
L
--
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
-
V
Q
--
Q
L
L
E
S
Y
F
D
G
K
K
A
S
K
G
I
N
P
D
E
A
V
A
---
Y
G
A
A
----
V
-----
Q
A
G
V
L
S
---------------------------------------------------------------------------------------------------
91
Fugue
73.01
15%
-2
- C5 -
1NBW
1
?
A:
[2-607]
P
L
I
A
G
I
D
IGNA
T
T
E
V
A
L
A
S
D
Y
P
Q
A
R
A
F
V
A
S
G
I
V
ATTGMKGTRDN
I
A
G
T
L
A
A
L
E
Q
A
L
A
K
T
P
W
S
M
S
D
V
S
R
I
Y
L
N
E
A
A
P
V
I
G
D
V
A
M
E
T
I
T
E
T
I
I
T
E
--------
S
T
M
I
G
H
N
P
Q
T
P
G
G
V
G
V
G
V
G
T
T
I
A
L
G
R
L
A
T
L
P
A
A
Q
Y
A
E
G
W
I
--
V
L
I
D
-
D
-
A
V
-----------
D
-----------
F
------------
L
D
A
V
W
---------
W
L
N
E
A
L
D
R
G
I
--
N
V
V
A
A
I
L
K
K
D
D
---
G
V
L
V
----------------------------
N
N
R
L
R
KT
L
P
V
V
D
E
V
T
-----
L
L
---
E
Q
V
P
E
G
V
M
A
A
V
E
V
--
A
A
P
G
Q
V
V
R
I
L
S
N
P
Y
G
I
A
T
F
F
G
L
S
P
E
E
-
T
Q
A
I
V
P
I
A
R
A
L
I
G
N
R
S
A
V
V
L
K
T
P
Q
G
D
V
Q
S
R
V
I
P
A
G
N
L
Y
I
S
G
EK
R
R
G
E
A
D
-----
V
A
E
G
A
E
A
I
M
Q
A
M
S
A
C
A
P
V
R
D
I
-
R
G
E
P
G
T
H
-------
A
G
G
M
L
E
R
V
R
K
V
M
A
S
L
T
G
H
E
M
S
A
I
Y
I
Q
D
L
L
A
V
D
T
F
I
P
R
K
V
Q
G
G
M
A
G
E
C
A
M
E
N
-
A
V
G
M
A
A
M
V
K
A
D
R
L
Q
M
-
Q
V
I
A
R
E
L
S
A
R
L
Q
T
E
V
V
V
-------
G
G
-------
V
E
A
N
M
--
A
I
A
G
A
L
T
T
-
P
-
G
C
A
A
P
L
A
I
L
D
L
G
A
G
S
T
D
A
A
I
-----
V
N
A
E
G
Q
-
I
T
A
V
H
L
A
G
A
G
N
M
V
--
S
L
L
I
K
--
T
E
L
G
L
E
D
L
S
L
A
E
A
I
K
K
Y
P
L
-
A
K
VE
S
L
F
S
I
R
H
E
N
G
A
V
E
F
F
R
E
A
L
S
P
A
V
FA
K
V
V
Y
I
K
EG
E
L
-----
V
P
I
D
N
A
S
P
L
E
K
I
R
L
V
R
R
Q
A
K
E
K
V
F
V
T
N
C
L
R
A
L
R
Q
V
S
P
G
G
SIRD
I
A
F
V
V
L
V
G
-
G
S
S
L
D
-
F
E
I
P
Q
L
I
T
E
A
L
S
H
Y
G
V
V
A
G
Q
G
N
I
RG
T
E
G
P
---
R
N
A
V
A
T
G
L
L
L
A
G
Q
A
N
96
Fugue
70.97
17%
-15
- C9 -
1DKG
-
DNAK_ECOLI
D:
[3-383]
----------------------------------------------KIIGIDLGT
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
--
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
---------
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
----
A
I
K
R
L
I
G
--
R
R
F
Q
D
E
--
E
V
-
Q
-
R
-
D
V
-----------
S
-----------
I
------------
M
P
F
K
I
-------
I
A
A
D
N
G
D
A
W
V
E
V
----
K
G
--
Q
K
M
A
P
---
P
Q
I
S
----------------------------
A
E
V
L
K
--
K
M
K
K
T
A
E
D
-----
Y
L
---
G
E
P
V
T
----
E
A
V
I
--
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
-
A
---
G
-
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
--
T
---
G
N
R
T
I
A
--
V
Y
D
L
G
G
----
G
T
F
D
-----
I
S
I
I
E
I
D
E
----
K
T
F
E
V
L
A
----
T
N
G
D
T
H
-------
L
G
G
--
E
D
F
D
S
R
L
I
-
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
--------------------
L
R
N
-
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
-
K
I
E
L
S
S
--------------------------
A
Q
Q
T
D
V
--
N
L
P
Y
I
T
A
D
-
A
-
T
G
---------
P
K
H
M
N
I
K
V
T
-----
R
A
K
L
E
S
-
L
V
E
D
L
V
N
----------------------------------------
R
S
I
E
L
L
K
V
A
L
Q
D
A
G
--
L
S
V
S
D
I
---
D
D
V
I
----
L
VGGQT
R
M
P
M
V
Q
K
K
V
A
E
F
F
G
-------------
K
E
P
R
K
D
V
N
P
D
E
A
----
V
A
I
G
A
A
V
Q
G
G
V
L
T
-------------------------------------------------
67
HHSearch
69.15
13%
-25
- C9 -
3D2F
3
?
A:
[8-360]
---------------------------------------------------------
D
L
G
N
N
N
S
V
L
A
V
A
R
N
R
G
I
D
I
V
V
N
E
V
S
N
R
S
T
P
S
V
V
G
-----
F
G
P
-
K
N
R
Y
L
G
E
T
G
K
N
K
Q
T
S
N
I
K
----
N
T
V
A
N
L
K
R
I
I
G
L
D
Y
H
H
P
D
F
E
Q
E
S
-
K
H
F
-
T
S
-----------
K
-----------
L
V
E
L
DDK
K
T
G
A
E
V
R
F
A
G
E
-------
K
H
V
F
S
A
T
Q
L
A
A
M
--
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
A
N
I
T
----------------------------
D
V
C
I
A
--
V
P
P
W
Y
T
E
E
-----
Q
R
---
Y
N
I
A
D
----
A
-------
A
R
------------
I
A
G
L
N
P
---
V
-
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
K
T
D
L
P
E
G
----
E
E
K
P
R
I
V
A
F
V
D
I
G
H
----
S
S
Y
T
-----
C
S
I
M
A
F
K
-------
K
G
Q
L
K
V
L
-
G
T
A
C
D
K
H
-------
F
G
G
--
R
D
F
D
L
A
I
T
E
H
F
A
D
E
F
K
T
K
---
Y
K
I
D
I
--------------------------
R
E
N
P
K
A
Y
N
R
I
-
L
T
A
A
E
K
L
K
K
V
L
S
A
N
T
N
---------------------
A
--
P
F
S
V
E
S
V
--
M
-
N
D
V
--
D
V
S
S
Q
L
S
R
E
E
L
E
E
L
V
-----
K
P
L
L
E
R
-
V
T
E
----
P
V
T
K
A
L
--
A
Q
A
K
L
--
S
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
-
L
K
--
Q
S
I
S
E
A
F
G
K
P
L
S
T
T
L
N
Q
D
E
A
I
A
K
---
G
A
A
F
----
I
-----
C
A
I
H
S
P
T
L
R
V
R
P
F
K
F
E
D
I
H
-----
P
Y
S
V
S
Y
S
W
D
K
Q
V
E
D
E
----
D
H
M
E
V
F
P
A
G
S
S
F
P
S
-
T
K
L
I
T
L
N
R
T
G
D
F
S
M
A
A
S
Y
T
------
D
I
T
Q
---
L
P
P
N
T
P
E
Q
I
A
N
W
E
I
T
98
Fugue
68.37
15%
-4
- C1 -
2HVG
8
?
A:
[21-478]
---------------------------------------------------------------
H
L
K
N
I
S
P
I
D
G
R
Y
K
K
A
C
G
E
L
S
A
F
F
S
E
H
A
L
I
K
H
R
I
I
V
E
V
R
W
L
L
F
L
N
E
E
E
L
F
F
E
K
V
T
D
H
S
V
E
V
L
N
Q
I
A
T
N
I
T
D
S
D
I
A
R
V
K
A
--
I
E
-
H
-
D
-
V
K
-----------
A
-----------
V
------------
E
Y
F
V
K
E
K
L
K
N
S
K
R
E
D
L
L
K
I
K
E
Y
V
H
YL
C
T
S
E
D
I
N
N
V
A
Y
---
A
T
C
L
----------------------------
K
A
C
L
N
--
D
V
V
I
P
C
L
E
-----
K
I
M
--
L
K
L
K
D
----
L
A
V
E
--
Y
S
H
V
P
L
L
S
R
T
H
G
Q
P
A
S
S
T
T
F
G
K
---
E
M
A
N
F
Y
A
R
I
H
H
H
V
G
V
I
R
R
V
K
V
----------------
C
A
K
F
N
G
----
A
V
G
N
-----
F
--------
N
A
H
K
V
A
S
K
D
T
D
W
-
V
N
T
I
G
L
F
-------
L
K
K
--
H
F
N
L
T
Y
S
I
Y
C
T
-----
Q
I
Q
D
H
D
Y
I
C
E
L
C
D
G
L
A
R
A
N
G
T
L
I
D
L
C
-
V
D
I
-
W
L
Y
I
S
N
N
L
L
K
L
K
S
S
T
M
P
H
K
V
N
P
I
D
F
E
N
A
E
G
N
L
H
-------
I
A
--
N
A
-
F
F
K
L
F
S
S
--
K
L
P
T
S
R
L
Q
-
R
-
D
L
S
D
S
T
V
L
------
R
N
I
G
S
S
-----
L
A
Y
C
L
I
-
A
Y
K
S
V
L
K
G
L
N
K
I
D
ID
R
R
N
L
E
--
E
E
L
N
Q
N
W
S
T
L
A
E
P
I
Q
I
--
V
M
K
R
--
H
N
Y
V
D
A
Y
E
E
L
K
Q
F
T
R
G
K
V
I
D
Q
K
I
M
Q
-
E
F
I
K
----
T
-----
K
C
A
F
L
P
Q
D
V
V
D
Q
L
L
E
----------------
L
T
P
A
T
Y
T
G
----
Y
A
D
Y
L
A
K
N
V
E
R
L
S
-------------------------------------------------
68
HHSearch
65.89
14%
-22
- C9 -
2V7Y
2
DNAK_GEOKA
A:
[8-329]
---------------------------------------------------------
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
-----
F
K
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-----
N
T
I
I
S
I
K
R
H
M
G
T
D
Y
K
V
-------------------------
E
-----------
I
----------------
E
-------
G
K
Q
Y
T
P
Q
E
I
S
A
I
--
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
----------------------------
R
A
V
I
T
--
V
P
A
Y
F
N
D
A
-----
Q
R
---
Q
A
T
K
D
----
A
-------
G
R
------------
I
A
G
L
E
V
---
E
-
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-----------
E
E
D
Q
T
I
L
V
Y
D
L
G
G
----
G
T
F
D
-----
V
S
I
L
E
L
G
-------
D
G
V
F
E
V
K
-
A
T
A
G
D
N
H
-------
L
G
G
--
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
---
G
I
D
L
--
S
------------------------
K
D
K
M
A
L
Q
R
L
-
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
Q
---------------------
T
--
Q
I
S
L
P
F
I
S
-
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
-----
A
H
L
V
E
R
-
T
M
G
----
P
V
R
Q
A
L
--
Q
D
A
G
L
--
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
-
V
Q
--
E
A
I
K
R
E
L
G
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
---
G
A
A
I
----
Q
-----
G
G
V
I
A
G
E
V
K
D
V
V
L
L
D
V
T
P
L
-----
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
----
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
-
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
------
P
M
A
A
---
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
89
Fugue
64.57
16%
14
- C3 -
4WW4
1
?
A:
[3-458]
-------------------------------------------------------------
Q
I
S
E
V
R
G
N
T
R
D
H
R
T
-
A
A
H
T
H
I
K
G
L
-----
G
L
N
S
S
G
I
A
E
K
Q
A
A
G
F
V
G
Q
C
A
A
R
E
A
C
G
V
V
V
D
L
I
K
A
----------------
H
--
K
M
-
A
-
G
-
R
G
-----------
V
-----------
L
------------
L
A
G
G
P
-------
G
T
G
---
K
T
A
L
A
L
--
A
I
S
Q
E
L
G
T
--
K
---
I
P
F
C
----------------------------
P
I
T
G
S
--
E
I
Y
S
T
E
V
K
-----
K
T
---
E
V
L
M
E
----
N
F
R
R
A
I
G
L
R
V
R
E
T
K
D
V
Y
E
G
E
V
S
--
T
L
L
I
---
G
-
L
K
S
A
----------------
R
G
Q
K
---
L
D
Q
K
E
R
V
Q
V
G
D
V
I
Y
----
I
E
T
N
-----
T
G
A
C
R
S
D
A
Y
A
T
E
--------
F
-
D
L
E
A
E
E
Y
-------
V
P
I
--
P
K
G
----
E
V
H
K
K
K
E
I
V
Q
D
V
T
L
H
D
L
D
V
A
N
A
R
P
D
I
I
S
M
M
--
G
Q
L
-
M
K
--------------
P
K
M
-
T
E
I
T
D
K
L
R
M
E
I
N
K
V
V
Q
K
-------
Y
I
--
N
----
Q
G
V
A
E
--
L
I
P
G
V
L
F
I
-
D
-
E
A
H
M
L
D
-------
I
E
C
F
T
Y
L
-----
N
K
A
L
E
S
-
P
I
A
P
I
V
V
L
A
S
N
R
G
--
I
A
T
I
R
GA
D
D
L
K
A
A
H
G
I
P
P
D
F
L
Q
R
L
L
I
-
I
P
--
T
--
H
P
Y
E
P
D
E
I
R
R
I
V
R
I
R
A
Q
T
E
---------------------
G
V
Q
L
T
D
A
A
V
D
R
V
A
E
H
G
-----
V
R
I
S
L
R
Y
C
L
Q
L
L
A
P
A
----
S
I
L
A
R
V
N
G
R
T
Q
V
D
V
-
Q
D
I
A
E
A
E
E
L
F
---------------
L
D
A
R
---
R
S
A
N
I
L
T
S
T
G
G
L
H
--
6
PsiBlast_PDB
57.93
29%
-11
- C11 -
3GDQ
3
HS71L_HUMAN
A:
[198-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
P
T
A
A
A
I
A
----
Y
G
L
D
K
G
------
E
R
H
V
L
--
I
F
D
L
G
G
----
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
-------------
T
A
G
D
T
H
-------
L
G
G
--
E
D
F
D
N
R
L
V
S
H
-
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
-
R
T
L
-
S
S
S
T
Q
A
N
L
E
I
D
S
L
Y
E
-
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
-------
A
D
--
L
F
-
R
G
T
L
E
P
V
--
E
K
A
L
R
D
A
K
-
M
-
D
K
A
K
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
V
-----
Q
R
L
L
Q
D
-
Y
F
N
G
R
D
L
N
K
S
I
N
P
--
D
E
A
V
A
--
Y
G
A
A
V
Q
A
A
I
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
56.95
11%
-34
- C9 -
2ZGY
2
PARM_ECOLX
A:
[79-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
--
V
H
H
A
L
L
T
S
G
L
P
---
V
S
E
V
----------------------------
D
I
V
C
T
--
L
P
L
T
E
Y
Y
D
RNNQP
N
T
---
E
N
I
E
R
----
K
K
A
N
-------
F
R
K
K
I
T
L
N
G
G
D
T
F
T
I
K
D
---
V
-
K
V
M
P
E
S
I
P
A
G
Y
E
V
L
Q
E
L
-----------
D
E
L
D
S
L
L
I
I
D
L
G
G
----
T
T
L
D
-----
I
S
Q
V
M
G
---------
K
L
S
G
I
S
-
K
I
Y
G
D
S
S
-------
L
G
V
--
S
L
V
T
S
A
V
K
D
A
L
S
L
A
-
R
T
----
K
G
S
----
S
-----------------------------------
Y
L
A
D
D
I
I
I
H
R
K
D
---------------------------
N
N
Y
--
L
-
K
----
Q
R
I
--
N
D
E
N
K
-
I
S
I
V
T
E
A
M
-----
N
E
A
L
R
K
-
L
E
Q
----
R
V
L
N
T
L
--
N
E
------
F
S
G
Y
T
H
V
M
V
I
G
G
G
A
E
L
---
I
C
--
D
A
V
K
K
H
T
Q
I
R
D
E
R
F
F
K
T
N
N
S
Q
Y
D
---
L
V
N
G
----
M
-----
Y
L
I
G
N
----------------------------------------------------------------------------------------------------
94
Fugue
56.72
16%
10
- C2 -
4K6N
1
PABC_YEAST
A:
[32-383]
----------------------------------------------------------------------
P
N
F
E
V
L
A
T
F
R
Y
D
P
G
F
A
R
Q
--
S
A
S
K
K
E
I
F
E
T
P
D
P
R
L
G
L
R
D
E
D
I
R
Q
Q
I
I
N
E
D
Y
S
S
Y
L
R
V
R
E
V
N
S
G
G
D
L
L
E
N
I
Q
--
H
P
-
D
-
A
-------------------------------------------
W
-------
K
H
D
C
K
T
I
--------
V
C
Q
R
V
E
D
M
L
Q
---
V
I
Y
E
----------------------------
R
F
F
L
-----------------------
L
D
E
----
Q
Y
Q
R
---
I
R
I
A
L
S
Y
-----------
F
K
I
---
D
-
F
S
T
S
-----------------
L
N
D
---
L
L
K
L
L
V
E
N
L
I
N
C
K
E
----
G
N
S
E
------
Y
H
E
K
I
Q
K
M
I
N
E
R
Q
C
Y
K
M
R
V
L
V
S
K
T
G
D
I
R
-------
I
E
A
--
I
P
M
----------------
P
M
E
P
I
L
K
L
T
T
D
Y
D
S
V
S
T
Y
F
I
K
T
M
-
L
N
G
F
L
I
D
S
T
I
N
W
D
V
V
V
S
S
--------------
E
P
L
N
A
-------
S
A
--
F
T
-
S
F
K
T
----------------
T
S
R
D
H
Y
A
R
A
R
V
R
M
Q
T
A
I
N
N
L
-----
R
G
S
--------------------------------------------------------------
E
P
T
S
S
V
S
Q
C
E
I
---
L
F
S
N
----
K
-----
S
G
L
L
M
E
G
S
I
T
N
V
A
V
I
Q
K
D
P
------
N
G
S
K
K
Y
V
T
P
R
L
A
T
G
----
C
L
C
G
T
M
R
H
Y
L
L
R
L
G
L
I
E
E
G
D
I
D
I
G
S
L
T
V
G
N
E
V
L
L
------
F
N
G
V
M
G
C
I
K
G
T
V
K
T
K
Y
------
11
PsiBlast_PDB
55.49
30%
1
- C11 -
3A8Y
1
HS71A_HUMAN
A:
[178-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
P
T
A
A
A
I
A
----
Y
G
L
D
R
T
G
K
---
G
E
R
N
V
L
--
I
F
D
L
G
G
----
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
-------------
T
A
G
D
T
H
-------
L
G
G
--
E
D
F
D
N
R
L
V
-
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
-
R
T
L
-
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
-
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
-------
S
D
--
L
F
-
R
S
T
L
E
P
V
--
E
K
A
L
R
D
A
K
-
L
-
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
-----
Q
K
L
L
Q
D
-
F
F
N
G
R
D
L
N
K
S
I
N
P
--
D
E
A
V
A
--
Y
G
A
A
V
Q
A
A
I
L
M
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
55.27
28%
-27
- C11 -
4J8F
5
F10A1_RAT (first)
A:
[181-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
P
T
A
A
A
I
A
----
Y
G
L
D
R
T
G
K
---
G
E
R
N
V
L
--
I
F
D
L
G
G
----
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
-------------
T
A
G
D
T
H
-------
L
G
G
--
E
D
F
D
N
R
L
V
-
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
-
R
T
L
-
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
-
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
-------
S
D
--
L
F
-
R
S
T
L
E
P
V
--
E
K
A
L
R
D
A
K
-
L
-
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
-----
Q
K
L
L
Q
D
-
F
F
N
G
R
D
L
N
K
S
I
N
P
--
D
E
A
V
A
--
Y
G
A
A
V
Q
A
A
I
L
M
G
L
E
S
D
L
E
I
-
D
N
--
E
G
V
I
E
A
D
T
D
A
P
Q
E
M
G
D
E
N
A
E
I
T
E
---
A
M
M
D
----
E
-----
A
N
E
K
K
G
A
A
I
D
A
L
N
D
G
E
L
Q
K
-----
A
I
D
L
F
T
D
A
I
K
L
N
P
R
L
----
A
I
L
Y
A
K
R
A
S
V
F
V
K
L
-
Q
K
P
N
A
A
I
R
D
C
D
R
A
I
E
I
N
P
D
------
S
A
Q
P
---
Y
K
W
R
G
K
A
H
R
L
L
G
H
W
E
73
HHSearch
53.29
14%
-40
* C10 *
1NBW
-
?
A:
[382-576]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Q
T
E
V
---
V
-
V
G
G
V
E
A
N
M
A
I
A
G
A
L
T
T
P
-----------
G
C
A
A
P
L
A
I
L
D
L
G
A
----
G
S
T
D
-----
A
A
I
V
N
A
E
-------
G
Q
I
------
T
A
V
H
L
A
-------
G
A
G
--
N
M
V
S
L
L
I
K
T
E
L
G
L
E
D
L
------------------------------------------------
S
L
A
E
A
I
K
K
Y
P
L
A
K
V
E
S
LF
S
I
R
H
E
N
G
A
V
E
F
F
R
E
A
L
S
P
A
--
V
F
A
K
V
V
Y
I
-
K
-
E
G
E
L
V
P
I
D
N
A
S
P
L
E
K
I
R
L
V
R
-----
R
Q
A
K
E
K
V
F
V
T
----
N
C
L
R
A
L
--
R
Q
V
S
P
GG
S
I
R
D
I
A
F
V
V
L
V
G
G
S
S
L
D
F
E
-
I
P
--
Q
L
I
T
E
A
L
S
H
Y
G
V
V
A
G
Q
G
N
I
R
G
T
E
---
G
P
R
N
----
A
-----
V
A
T
G
L
L
L
A
G
Q
A
N
---------------------------------------------------------------------------------------------
14
PsiBlast_PDB
51.52
30%
3
- C11 -
3AY9
3
HS71A_HUMAN
A:
[178-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
P
T
A
A
A
I
A
----
Y
G
L
D
R
T
G
K
---
G
E
R
N
V
L
--
I
F
D
L
G
G
----
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
-------------
T
A
G
D
T
H
-------
L
G
G
--
E
D
F
D
N
R
L
V
-
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
-
R
T
L
-
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
-
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
-------
S
D
--
L
F
-
R
S
T
L
E
P
V
--
E
K
A
L
R
D
A
K
-
L
-
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
-----
Q
K
L
L
Q
D
-
F
F
N
G
R
D
L
N
K
S
I
N
P
--
D
E
A
V
A
--
Y
G
A
A
V
Q
A
A
I
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
51.49
30%
-1
- C11 -
1S3X
4
HS71A_HUMAN
A:
[174-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
P
T
A
A
A
I
A
----
Y
G
L
D
R
T
G
K
---
G
E
R
N
V
L
--
I
F
D
L
G
G
----
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
-------------
T
A
G
D
T
H
-------
L
G
G
--
E
D
F
D
N
R
L
V
-
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
-
R
T
L
-
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
-
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
-------
S
D
--
L
F
-
R
S
T
L
E
P
V
--
E
K
A
L
R
D
A
K
-
L
-
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
-----
Q
K
L
L
Q
D
-
F
F
N
G
R
D
L
N
K
S
I
N
P
--
D
E
A
V
A
--
Y
G
A
A
V
Q
A
A
I
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
51.20
14%
-16
- C10 -
2D0O
2
DDRFA_KLEOK
A:
[297-575]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
G
E
S
G
T
N
I
G
G
--
M
L
E
H
V
R
Q
T
M
A
E
L
T
N
K
P
S
S
EIFIQ
D
L
L
A
V
D
T
S
V
P
V
S
V
TGGLAG
E
F
S
L
E
Q
A
V
G
--
I
A
S
M
V
K
S
D
-----
R
L
Q
M
A
M
I
A
R
E
----
I
-------
E
Q
------------
K
L
N
I
D
V
---
Q
-
I
G
G
A
E
A
E
A
A
I
L
G
A
L
T
T
P
-----------
G
T
T
R
P
L
A
I
L
D
L
G
A
----
G
S
T
D
-----
A
S
I
I
N
P
K
G
------
D
I
I
A
T
H
L
-
A
G
A
G
D
M
V
T
M
I
I
A
R
E
L
G
L
--
E
--
D
R
Y
L
A
E
E
I
K
K
Y
P
L
A
------------------------------------------------
K
V
E
S
L
F
H
L
R
H
E
D
G
S
---------
V
--
Q
F
-
F
S
T
P
L
P
P
AV
F
A
R
V
C
V
V
K
-
A
-
D
E
-
L
V
P
L
P
G
D
L
A
L
E
K
V
R
A
I
R
R
S
A
K
E
R
V
F
V
T
N
-
A
L
R
----
A
L
R
Q
V
S
--
P
T
G
N
I
----
R
D
I
P
F
V
V
L
V
G
G
S
S
L
D
F
E
-
V
P
--
Q
L
V
T
D
A
L
A
H
Y
R
L
V
A
G
R
G
N
I
R
G
S
E
---
G
P
R
N
----
A
-----
V
A
T
G
L
I
L
S
W
H
K
E
F
--------------------------------------------------------------------------------------------
78
HHSearch
51.15
12%
-22
- C9 -
3WQT
2
FTSA_STAAR
A:
[169-359]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
----------------------------
A
G
V
I
A
--
I
Q
K
----
S
-----
I
L
---
I
N
M
I
K
----
C
V
E
-------------------
A
C
G
V
D
V
---
L
-
D
V
Y
S
D
A
Y
N
Y
G
S
I
-
L
T
A
-
T
----------
E
K
E
L
G
A
C
V
I
D
I
G
E
----
D
V
T
Q
-----
V
A
F
Y
E
R
G
---------
E
L
V
----
D
A
D
S
I
E
-------
M
A
G
--
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
E
-------------------------------------------------
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
-------
S
A
----------
S
D
--
Q
D
I
F
T
V
E
Q
-
V
-
D
---
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
-----
E
A
R
V
E
E
-
I
F
F
----
E
V
F
D
V
L
--
Q
D
L
G
L
--
T
-
K
V
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
-
V
K
--
E
L
L
S
D
M
V
S
E
K
V
R
I
H
T
P
S
Q
M
G
I
R
K
---
P
E
F
S
----
S
-----
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
-----------------------------------------------------------------------------------------
18
PsiBlast_PDB
51.01
30%
3
- C11 -
1HJO
1
HS71A_HUMAN
A:
[172-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
P
T
A
A
A
I
A
----
Y
G
L
D
R
T
G
K
---
G
E
R
N
V
L
--
I
F
D
L
G
G
----
G
T
F
D
V
S
I
L
T
I
D
D
G
I
F
E
V
K
A
-------------
T
A
G
D
T
H
-------
L
G
G
--
E
D
F
D
N
R
L
V
-
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
-
R
T
L
-
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
-
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
-------
S
D
--
L
F
-
R
S
T
L
E
P
V
--
E
K
A
L
R
D
A
K
-
L
-
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
-----
Q
K
L
L
Q
D
-
F
F
N
G
R
D
L
N
K
S
I
N
P
--
D
E
A
V
A
--
Y
G
A
A
V
Q
A
A
I
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
82
HHSearch
50.89
12%
-27
- C9 -
3WT0
1
FTSA_STAAW
A:
[192-360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
G
V
D
V
---
L
-
D
V
Y
S
D
A
Y
N
Y
G
S
I
-
L
T
A
-
T
----------
E
K
E
L
G
A
C
V
I
D
I
G
E
----
D
V
T
Q
-----
V
A
F
Y
E
R
G
---------
E
L
V
D
----
A
D
S
I
E
-------
M
A
G
--
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
E
-------------------------------------------------
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
-------
S
A
----------
S
D
--
Q
D
I
F
T
V
E
Q
-
V
-
D
---
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
-----
E
A
R
V
E
E
-
I
F
F
----
E
V
F
D
V
L
--
Q
D
L
G
L
--
T
-
K
V
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
-
V
K
--
E
L
L
S
D
M
V
S
E
K
V
R
I
H
T
P
S
Q
M
G
I
R
K
---
P
E
F
S
----
S
-----
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
-----------------------------------------------------------------------------------------