@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0121: (2015-12-12 )
MAQEKAVIRDPKKLNAFDLRWIASLFGTAVGAGILFLPIRAGGHGIWAIVVMSAIIFPLTYLGHRALAYFIGSKDKEDITMVVRSHFGAQWGFLITLLYFLAIYPICLAYGVGITNVFDHFFTNQLHLAPFHRGLLAVALVSLMMLVMVFNATIVTRICNALVYPLCLILLLFSLYLIPYWQGANLFVVPSFKEFVLAIWLTLPVLVFSFNHSPIISTFTQNVGKEYGAFKEYKLNQIELGTSLMLLGFVMFFVFSCVMCLNADDFVKAREQNIPILSYFANTLNNPLINYAGPVVAFLAIFSSFFGHYYGAKEGLEGIIIQSLKLKQASKTLSVGVTIFLWLTITLVAYINPNILDFIENLGGPIIALILFVMPMIAFYSVSSLKRFRNFKVDIFVFVFGSLTALSVFLGLF
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------.........-10..--.---.....20..--------....------..30-......-.-.---.40-..-----------....--..---50.----......----.60.-......----.70.-----.....----..80----..------..-------------..---------...-----90-......--------------..100.---......110------.......-------------..----------120.......130.......140.-------....---..150-----.......160....-....170-.....-------..--..180.----...-----...-190......----.200.......210.....---..220----........230---....---.------....240.......250.....--------------...--.260.-..--....270--------------------------------........280.-----......--290......----.300.---------.--.......310..---..--...320.---------.-----..--..-.330.......340---......------------..350.......360--------...-------------.---...370....------...380------------....--...-..390-.-----..-......400.--------.-..-...410.-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------MAQE
K
A
VIR-DPKK--L---
N
A
F
D
L
R
W
I
A
--------
S
L
F
G
------
T
A
V--GA
G
I
L
F
-
L
-
P
---
I
RA-GG-----------
H
G
I
W
--
A
I
---
V
V
M
----
S
A
I
I
F
P
----
L
T
Y
L
-
G
H
R
A
L
A
----
Y
F
IG-----SKDK
E
----
D
I
T
-----
M
V
------
V
R
-------------
S
H---------FGA-----
Q
W
-
G
F
L
I
T
L
--------------
L
Y
F
L
A
I
---
Y
P
I
C
L
A
Y--------GV
G
I
T
N
V
-------------
F
D
----------
H
F
F
TNQL
H
L
A
P
F
H
R
G
L
L
A
V
A
L
V
S
L
-------
M
M
L
V
---
M
V
FN
A
-----
T
I
V
T
R
I
C
N
-
A
L
V
Y
P
-
L
C
L
I
L
---
L
L
F
S
L
-------
Y
L
--
I
PYWQG----
A
N
L
-----
F
V
V-P
S
F
K
E
F
V
L
A
----
I
W
L
T
L
P
V
L
V
FSFNHS
P
I
I
S
---
T
F
T
Q
-----
N
V
G
K
E
YGAF-----K
E
Y
K
---
L
------
N
Q
I
ELG
T
S
L
M
L
L
G
F
V
--
M
F
F
V
F
--------------
S
C
V
--
M
CL
N
A
-
D
D
--
F
V
K
A
R
E---------------------------------QNI
P
I
L
S
Y
F
A
N
T-----LNNPLI--NY
A
G
P
V
V
A
F
----
L
A
--
I
---------
F
--
S
S
F
F
G
H
YY
G
A
K
E---GL--
E
G
I
I
I
Q
S
---------
L
-----
K
L
--
K
Q-ASK
T
L
SV
G
V
T
I
F
L
----
W
L
T
I
T
L
------------
V
A
YIN
P
N
I
L
D
F
I
E
NL--------G
G
P
-------------
I
---
I
A
L
I
L
F
V
M
P
M
------
I
A
F
Y
--------------
S
V
S
S
--
L
K
R
-
F
RN---F-----
K
V
-
D
I
F
V
F
V
F
G
S
L
--------
T
-
A
L
-
S
V
F
LGLF-----------
9
HHSearch
86.55
14%
-149
- C2 -
3L1L
2
ADIC_ECO57
A:
[7-379]
----------------------------------------------------------------------------------------------------------------------
A
--
H
---
K
V
G
L
I
P
V
T
L
--------
M
V
S
G
------
A
I
M
--
G
S
G
V
F
L
-
L
-
P
---
A
N
L
-
A
S
-----------
T
G
G
---
I
A
---
I
Y
G
----
W
L
V
T
I
I
----
G
A
L
G
-
L
S
M
V
Y
A
----
K
M
S
F
-----
L
D
P
S
P
G---
G
S
Y
-----
A
Y
------
A
R
-------------
R
C
---------
F
G
P
-----
F
L
-
G
Y
Q
T
N
V
--------------
L
Y
W
L
A
C
---
W
I
G
N
I
A
M
--------
V
V
I
G
V
G
Y
-------------
L
S
----------
Y
F
F
P
I
L
--
K
D
P
W
V
L
T
I
T
C
V
V
V
L
W
I
-------
F
V
L
L
---
N
I
V
G
P
-----
K
M
I
T
R
V
Q
A
-
V
A
T
V
L
-
A
L
I
P
I
---
V
G
I
A
V
-------
F
G
--
W
F
W
F
R
G
----
E
T
Y
-----
M
A
----------
A
----
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
---
V
A
A
G
-----
V
V
K
-----
N
-----
P
K
R
N
---
V
------
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
--
V
L
S
T
T
--------------
A
I
M
--
G
M
I
P
N
-
A
A
--
L
R
---
V
---------------------------------
S
A
S
P
-
F
G
D
A
A
R
M
-----
A
L
G
D
T
A
--
G
A
I
V
S
F
C
A
A
----
A
G
--
C
---------
L
--
G
S
L
G
G
W
T
L
L
A
G
Q
---
T
A
--
K
A
A
A
D
D
G
L--------
F
-----
P
P
IF
A
R
V
N
K
A
G
T
P
V
A
G
L
I
I
V
----
G
I
L
M
T
I
F
Q
----------
L
S
S
I
S
P
N
A
T
K
E
F
G
L
V
--------
S
S
V
-------------
S
V
I
-
F
T
L
V
P
Y
L
Y
T
C
------
A
A
L
L
--------------
L
L
G
H
--
G
H
F
-
G
K
A
---
R
-----
P
A
-
Y
L
A
V
T
T
I
A
F
L
--------
Y
-
C
I
-
W
A
V
V
G
S
G
-----------
26
Fugue
85.94
22%
-181
- C1 -
4UNM
4
?
A:
[8-615]
---------------------------------------------------------------------------------------------------------
K
Y
H
Q
Y
K
I
N
Q
-
P
E
Y
K
--
A
---
A
N
G
K
W
E
I
I
E
F
PEKYRQN
T
I
H
A
------
A
L
L
--
R
T
G
K
V
L
-
M
-
V
---
A
G
S
-
G
N
N
Q
D
N
S
D
D
KQ
Y
D
T
R
I
W
--
D
P
---
V
K
G
----
T
I
K
K
V
P
TPSD
L
F
C
T
-
G
H
T
Q
L
A
NG
N
L
L
I
A
G
GTKRY
E
K
L
K
G
----
D
V
T
K
A
G
G
L
M
V
------
V
H
-------------
N
E
NPD
K
P
I
T
L
P
A
G
T
-----
K
F
-
T
G
K
E
N
G
--------------
K
T
F
V
S
K
---
D
P
V
L
V
P
R
AEKVRND
P
G
L
G
R
I
Y
V
E
A
QKSGSAYETG
T
E
D
----------
N
Y
R
V
Q
G
L
S
G
A
D
A
R
N
T
Y
G
I
A
Q
K
L
A
L
D
K
K
D
F
Q
G
I
R
D
A
---
F
E
F
D
P
VAE
K
Y
I
K
V
D
P
M
H
E
-
A
R
W
Y
P
-
T
L
T
T
L
GDG
K
I
L
S
V
S
G
L
DDIG
Q
L
--
V
P
---
G
----
K
N
E
-----
V
Y
D
-
P
K
T
K
A
W
T
Y
T
D
K
V
R
Q
F
P
T
Y
P
A
L
F
L
M
Q
N
G
K
I
F
Y
S
---
G
A
N
A
GYGPD
D
V
G
R
T
P
G
V
W
DVETN
K
F
T
K
---
V
P
GMSDA
N
M
L
E
T
A
N
T
V
L
L
P
P
A
Q
DE
K
Y
M
V
I
G
GGGVGESKLSSE
K
T
R
I
--
A
D
L
K
A
-
D
D
P
K
F
V
D
G
P
S
LE
K
G
T
R
Y
P
Q
A
S
I
L
PDD
S
V
L
V
S
G
G
S
QDYRGRGDS
N
I
L
Q
A
R
L
Y
H
P
D
T
N
E
F
E
R
V
A
D
P
L
V
G
R
N
Y
H
S
G
S
I
L
L
PDG
R
L
M
--
F
---------
F
G
S
D
S
L
Y
A
D
K
A
N
T
K
P
---
G
K
F
E
Q
R
I
E
I
Y
T
P
P
Y
L
Y
R
DS
R
P
-----
D
L
--
S
G
-
G
P
Q
T
I
A
R
G
G
S
G
T
F
T
S
RA
A
S
T
V
K
K
------------
V
R
L
I
R
P
S
A
S
T
H
V
T
D
V
--------
D
Q
R
-------------
S
---
I
A
L
D
F
K
A
D
G
D
------
K
L
T
V
--------------
T
V
P
S
--
G
K
N
-
L
V
Q
---
S
-----
G
W
-
Y
M
M
F
V
T
D
G
E
G
--------
T
P
S
K
-
A
E
W
V
R
V
P
-----------
24
Fugue
80.73
17%
-156
- C3 -
4KRT
10
?
A:
[7-353]
---------------------------------------------------------------------------------------------------------
H
H
H
H
H
M
Q
S
R
-
N
N
N
N
--
L
---
K
G
I
D
V
----------------------
S
N
W
--
K
G
N
I
N
F
-
E
-
S
---
V
K
N
-
D
G
-----------
V
E
V
V
--
Y
I
---
K
A
T
----
E
G
N
Y
F
K
----
D
K
Y
-----
A
K
Q
----
N
Y
E
G
-----
A
K
E
Q
-----
G
L
S
-----
V
G
------
F
Y
-------------
H
F
---------
F
R
A
-----
N
K
-
G
A
K
D
Q
A
--------------
N
F
F
I
D
Y
---
L
N
E
I
G
A
V
--------
N
Y
D
C
K
L
A
-------------
L
D
----------
I
E
T
T
E
G
V
G
----
V
R
D
L
T
S
M
C
I
E
F
L
-------
E
E
V
K
---
R
L
T
G
K
-----
E
V
V
V
Y
T
Y
T
-
S
F
A
N
N
N
L
D
S
R
L
---
G
N
Y
P
V
-------
W
I
--
A
H
Y
--
G
----
V
N
T
-----
P
G
A
-
N
N
I
W
S
S
W
V
G
----
F
Q
Y
S
E
N
G
S
V
A
G
V
N
G
G
C
D
M
N
---
E
F
T
E
-----
E
I
F
I
D
S
S
N
F
-----
N
L
D
N
---
A
------
T
T
K
N
V
S
T
K
L
N
I
R
-----------------------------------------
A
K
G
T
---------------------------------
T
N
S
K
I
I
G
S
I
P
-----------------
A
G
E
T
F
K
I
----
K
W
--
V
---------
D
--
E
D
Y
L
G
W
Y
Y
V
E
Y
N
---
G
V
--
V
G
Y
V
N
A
D
Y--------
V
-----
E
K
--
L
Q
-
M
A
T
T
Y
N
V
S
T
--------
F
L
N
V
R
E
------------
E
G
S
L
N
S
R
I
V
D
K
I
N
S
----------
G
D
-------------
I
---
F
R
I
D
W
V
D
S
D
F
------
I
G
W
Y
--------------
R
I
T
T
--
K
N
G
-
K
V
G
---
F
-----
V
N
-
A
E
F
V
K
K
L
----------------------------------
23
Fugue
80.37
18%
-158
- C3 -
4HU8
3
?
A:
[3-452]
---------------------------------------------------------------------------------------------------N
E
I
T
L
T
I
G
Q
Q
K
D
L
A
S
M
V
P
A
K
--
F
---
A
G
Q
E
L
S
W
T
S
--------
S
D
P
E
------
T
A
S
V
T
D
K
G
I
V
T
A
L
-
K
---
F
S
S
-
G
G
-----------
A
N
L
F
LK
A
P
---
A
T
G
----
E
A
I
I
T
V
----
T
A
G
K
-
Q
S
H
S
V
K
----
V
I
T
T
-----
V
K
G
K
E
----
D
I
E
-----
K
L
PP----
L
K
-------------
D
H
---------
F
K
D
------------------------------
Y
F
L
I
---
G
N
I
F
N
N
R
--------
D
V
S
G
S
M
M
-------------
D
N
----------
D
W
L
A
H
H
Y
A
I
L
T
P
E
N
H
M
K
P
S
N
L
T
N
N
-------
R
N
E
T
TG
E
I
T
Y
T
F
-----
S
T
A
D
R
M
V
N
-
A
A
I
A
E
-
G
L
K
I
H
---
G
H
T
L
L
-------
W
H
QQ
I
P
P
W
Q
R
----
S
M
E
SAA
K
D
A
A
L
-
S
V
M
K
K
Y
I
T
E
----
V
M
T
H
Y
K
G
K
I
Y
S
W
D
V
L
N
E
I
-----
F
P
D
-----
G
R
G
D
N
W
T
T
A
-----
M
R
P
E
-----------------
N
P
W
F
K
S
I
G
--
S
D
F
V
Y
--------------
E
A
Y
--
L
A
A
R
Q
-
A
D
--------------------------------------------
P
N
A
I
L
Y
Y
N
D
-----
Y
N
M
D
Q
A
--
G
K
A
A
L
I
A
A
M
----
V
R
--
D
---------
V
--
N
A
K
Y
K
Q
A
Y
P
R
E
T
---
R
L
LI
E
G
I
G
M
Q
S
---------
H
HNMDV
P
A
--
S
N
-
I
R
N
T
I
N
R
Y
R
E
L
G
V
----
K
I
S
V
S
E
------------
L
D
I
L
C
M
G
W
S
A
F
R
G
S
T
--------
G
Q
G
ADKDDMTIAT
N
R
N
I
---
L
D
Q
A
Y
K
F
N
E
Y
------
M
K
L
Y
--------------
L
E
N
S
DI
I
E
R
-
V
S
M
---
W
-----
G
V
S
D
R
Y
S
W
R
S
G
G
L
PLLFDADN
K
-
A
K
-
P
A
Y
Y
S
F
V
R
A
R
E
D
Y
E
A
A
K
A
10
HHSearch
75.50
12%
-150
- C2 -
3GIA
6
Y609_METJA
A:
[3-369]
--------------------------------------------------------------------------------------------------------------------
L
K
N
--
K
---
K
L
S
L
W
E
A
V
S
--------
M
A
V
G
------
V
M
I
--
G
A
S
I
F
S
-
I
-
F
---
G
V
G
A
K
I
-----------
A
G
R
---
N
L
---
P
E
T
----
F
I
L
S
G
I
----
Y
A
L
L
-
V
A
Y
S
Y
T
----
K
L
G
A
-----
K
I
V
S
N
A---
G
P
I
-----
A
F
------
I
H
-------------
K
A
---------
I
G
D
-----
N
I
I
T
G
A
L
S
I
--------------
L
L
W
M
S
Y
---
V
I
S
I
A
L
F
--------
A
K
G
F
A
G
Y
-------------
F
L
----------
P
L
I
N
A
P
--
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
-------
F
T
A
L
---
N
F
F
G
S
-----
K
A
V
G
R
A
E
F
-
F
I
V
L
V
-
K
L
L
I
L
---
G
L
F
I
F
-------
A
G
--
L
I
T
I
H
P
----
S
Y
V
-----
I
P
D
-
L
A
-
P
S
A
V
S
G
----
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
---
N
A
S
E
-----
H
I
E
-----
N
-----
P
K
K
N
---
V
------
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
--
V
G
V
A
I
--------------
S
A
I
--
G
N
L
P
I
-
D
E
--
L
I
K
--
A
---------------------------------
S
E
-
N
A
L
A
V
A
A
K
P
-----
F
L
G
N
L
G
--
F
L
L
I
S
I
G
A
L
----
F
S
--
I
---------
S
--
S
A
M
N
A
T
I
Y
G
G
A
N
---
V
A
--
Y
S
L
A
K
D
G
E--------
L
-----
P
E
FF
E
R
K
V
W
F
K
S
T
-
E
G
L
Y
I
T
----
S
A
L
G
V
L
------------
F
A
L
-
L
F
N
M
E
G
V
A
S
I
---------
T
S
A
-----------------
V
F
M
V
I
Y
L
F
V
I
------
L
S
H
Y
--------------
I
L
I
D
--
E
V
G
-
G
R
K
---
E
-----
I
V
-
I
F
S
F
I
V
V
L
G
V
--------
F
-
L
L
-
L
L
Y
Y
Q
W
I
-----------
20
Fugue
74.37
15%
-150
- C4 -
3PV2
-
?
A:
[6-439]
---------------------------------------------------------------------------------------------------------
M
P
S
M
A
P
V
L
K
-
N
I
M
P
A
I
V
---
N
V
A
V
Q
G
Y
L
P
--------
N
R
K
F
------
E
S
I
--
G
S
G
V
I
I
-
D
-
P
--------
N
-----------
N
G
V
I
--
I
T
N
DH
V
I
R
----
N
A
S
L
I
T
----
V
T
L
Q
D
G
R
R
L
K
A
----
R
L
I
G
-----
G
D
S
E
T
----
D
L
A
-----
V
L
K
I
D
A
K
N
L
K
-------------
S
L
---------
V
I
G
-----
D
S
-
D
K
L
E
V
G
--------------
D
F
V
V
A
I
G
N
P
F
G
L
S
Q
S
A
--------
T
F
G
I
V
S
A
-------------
L
K
----------
N
F
I
Q
T
D
---
A
A
I
N
P
G
N
S
G
G
A
L
V
N
A
-------
K
G
E
L
---
I
G
I
N
T
-----
A
I
L
V
G
I
G
F
-
A
I
P
I
N
-
M
V
K
D
V
---
A
Q
Q
I
I
-------
K
F
--
G
S
I
H
R
G
----
L
M
G
-----
I
F
V
-
Q
H
L
----------------------------------
T
P
-----
E
L
A
Q
A
M
G
Y
P
-----
E
D
F
Q
G
A
L
V
------
S
Q
V
N
P
N
S
P
A
E
L
A
G
L
K
--
A
G
D
I
I
--------------
T
Q
I
ND
T
K
I
T
Q
-
A
T
--
Q
V
K
T
T
I
---------------------------------
S
L
L
R
V
G
S
T
V
K
I
I
-----
V
E
R
D
----
N
K
P
L
T
L
S
A
V
----
V
T
--
D
---------
I
--
K
S
H
E
Q
K
L
Q
S
N
N
P
---
F
L
--
Y
G
L
A
L
R
A
---------
F
-----
E
Q
--
E
S
-
P
P
H
G
N
V
I
G
V
Q
V
V
G
----
A
S
E
N
S
A
------------
G
W
R
A
G
I
R
P
G
D
I
I
I
S
A
--------
N
K
K
-------------
P
---
V
T
--------------------------------
D
V
K
S
--
L
Q
T
I
A
Q
E
---
K
-----
K
K
-
E
L
L
V
Q
V
L
R
G
P
--------
G
-
S
M
-
Y
L
L
V
I
-------------
19
Fugue
70.41
11%
-136
- C4 -
3L24
4
PEPQ_ALTSX
A:
[1-440]
---------------------------------------------------------------------------------------------------------
M
N
K
L
A
V
L
Y
A
-
E
H
I
A
--
T
---
L
Q
K
R
T
R
E
I
I
--------
E
R
E
N
------
L
D
G
--
V
V
F
H
S
G
-
Q
-
A
---
K
R
Q
-
F
L
-----------
D
D
M
Y
--
Y
P
---
F
K
V
----
N
P
Q
F
K
A
----
W
L
P
V
-
I
D
N
P
H
C
----
W
I
V
A
-----
N
G
T
D
K
----
P
K
L
-----
I
F
------
Y
R
P
V
D
FW
H
K
V
P
D
EPN
E
Y
---------
W
A
D
-----
Y
F
-
D
I
E
L
L
V
KPDQVEKLLPYDKA
R
F
A
Y
I
G
---
E
Y
L
E
V
A
Q
--------
A
L
G
F
E
L
M
-------------
N
P
----------
E
P
V
M
N
F
Y
H
Y
H
R
A
Y
K
T
Q
Y
E
L
A
C
M
R
E
-------
A
N
K
I
---
A
V
Q
G
H
-----
K
A
A
R
D
A
F
F
-
Q
G
K
S
-----
E
F
---
E
I
Q
Q
A
-------
Y
L
--
L
A
T
Q
H
S
----
E
N
D
-----
N
P
Y
-
G
N
----
I
V
A
----
L
N
E
N
C
A
I
L
H
Y
T
H
F
D
R
V
A
P
A
THR
S
F
L
I
-----
D
A
G
A
N
F
N
G
Y
-----
A
A
D
I
---
T
------
R
T
Y
D
F
T
G
E
G
E
F
A
E
L
V
--
A
T
M
K
Q
--------------
H
Q
I
--
A
L
M
N
Q
L
A
P
--
G
K
L
Y
G
E
---------------------------------
L
H
L
D
C
H
Q
R
V
A
Q
T
-----
L
S
D
F
N
I
---
V
D
L
S
A
D
E
I
----
V
A
K
G
I
---------
T
--
S
T
F
F
P
H
G
L
G
H
H
I
---
G
L
--
Q
V
H
D
V
G
G
---------
F
-----
M
A
--
L
R
-
C
T
R
K
I
E
A
N
----
Q
----
V
F
T
I
E
P
------------
G
L
Y
F
I
D
S
L
L
G
D
L
A
A
T
------------------------------------
D
N
------
N
Q
H
I
--------------
N
W
D
K
--
V
A
E
-
L
K
P
FG
G
I
-----
R
I
E
D
N
I
I
V
H
E
D
S
L
--------
E
-
N
M
-
T
R
E
L
R
L
R
-----------
27
Fugue
63.57
13%
-150
* C3 *
3IJD
2
?
A:
[3-305]
---------------------------------------------------------------------------------------------------------
L
L
K
Q
K
I
L
N
R
-
E
S
G
---------------------------------------------------------------------------------
I
I
----
T
Y
G
I
T
P
----
P
K
K
N
-
N
T
E
E
K
I
----
K
E
I
S
-----
Q
K
H
I
E
----
R
I
S
-----
G
L
----------------------------------------
D
I
-
D
G
L
V
I
------------------------------
Y
--------
D
L
Q
F
I
E
T
-------------
I
D
----------
P
Q
I
Y
S
E
N
Y
L
K
D
L
K
I
P
------
K
I
I
-------
Y
R
C
V
---
G
K
Y
T
P
-----
D
E
F
R
R
L
T
R
-
P
V
------------------------------
S
G
Q
D
----
A
F
S
-----
V
F
V
-
G
A
A
S
V
L
L
K
L
----
S
D
A
Y
K
I
R
Q
D
V
N
P
D
L
L
L
G
G
V
---
A
I
P
E
-----
R
H
M
K
N
T
D
E
H
-----
L
R
I
I
----------
D
K
I
N
K
G
C
K
Y
F
I
T
Q
A
----
V
Y
N
V
--------------
E
A
A
--
K
D
F
L
S
-
D
Y
--
Y
Y
Y
S
K
N
---------------------------------
N
N
L
K
M
V
-----------------------
P
I
I
F
T
----
L
T
--
P
---------
C
--
G
S
----------------------------------------
T
--
K
T
-
L
E
F
M
K
W
L
G
I
S
I
P
R
----
W
L
E
N
D
L
------------
M
N
C
--
E
D
I
L
N
K
S
V
S
L
--------
S
K
S
-------------
I
---
F
N
E
L
M
E
F
C
L
E
K
GI
P
I
G
C
N
I
E
--------------
S
V
S
V
-------
R
K
---
V
-----
E
I
-
E
A
S
I
A
L
A
K
D
I
--------
K
-
Y
I
-
M
-----------------
25
Fugue
62.18
14%
-173
- C3 -
4WWX
1
RAG1_MOUSE
B:
[1-618]
APRQHLLSLTRRAQKHRLRELKIQVKEFADKEEGGDVKAVCLTLFLLALRARNEHRQADELEAIMQGRGSGLQPAVCLAIRVNTFLSCSQYHKMYRTVKAITGRQ
I
F
Q
P
L
H
A
L
R
-
N
A
E
K
--
V
LLP
G
Y
H
P
F
E
W
Q
P
--------
P
L
K
N
VSSRTD
V
G
I
--
I
D
G
L
S
G
-
L
-
A
---
S
S
V
-
D
E
-----------
Y
P
V
D
--
T
I
---
A
K
R
FRYD
S
A
L
V
S
A
----
L
M
D
M
-
E
E
D
I
L
E
----
G
M
R
S
-----
Q
D
L
D
D
YLNG
P
F
T
-----
V
V
------
V
K
-------------
E
S
---------
C
D
G
MGDVS
E
K
-
V
P
E
K
A
V
--------------
R
F
S
F
T
V
---
M
R
I
T
I
E
H
--------
G
S
Q
N
V
K
V
-------------
F
E
EPKPNSELCC
K
P
L
C
L
M
L
A
D
E
S
D
H
E
T
L
T
A
I
L
S
P
L
I
-------
A
E
R
E
---
A
M
K
S
S
-----
E
L
T
L
E
M
G
G
I
P
R
T
F
K
-
F
I
F
R
G
---
T
G
Y
D
E
-------
K
L
--
V
R
E
V
E
G
LEAS
G
S
V
-----
Y
I
C
-
T
L
C
D
T
T
R
L
E
----
A
S
Q
N
L
V
F
H
S
I
T
R
S
H
A
E
N
L
Q
---
R
Y
E
V
-----
W
R
S
N
P
Y
H
E
S
-----
V
E
E
L
---
R
------
D
R
V
K
G
V
S
A
K
P
F
I
E
T
V
--
P
S
I
D
A
--------------
L
H
C
--
D
I
G
N
A
-
A
E
--
F
Y
K
I
F
Q
---------------------------------
L
E
I
G
E
V
Y
K
H
P
N
A
-----
S
K
E
E
R
K
--
R
W
Q
A
T
L
D
K
H
----
L
R
--
K
RMNLKPIMR
M
--
N
G
N
F
A
R
K
L
M
T
Q
E
---
T
V
--
D
A
V
C
E
L
----------
I
-----
P
S
--
E
E
-
R
H
E
A
L
R
E
L
M
D
L
Y
L
----
K
M
K
P
V
W
RSSCPAKECPES
L
C
Q
Y
S
F
N
S
Q
R
F
A
E
L
L
STKFKYRY
E
G
K
-------------
I
TNY
F
H
K
T
L
A
H
V
P
E
------
I
I
E
R
DGSIGAWASEGNES
G
N
K
L
--
F
R
R
-
F
R
K
---
M
NARQS
K
C
-
Y
E
M
E
D
V
L
K
H
H
--------
W
-
L
Y
T
S
K
Y
L
Q
K
F
MNAHNA-----
18
Fugue
57.84
21%
-138
- C4 -
4R1D
-
?
B:
[1-301]
---------------------------------------------------------------------------------------------------------
M
D
K
T
G
---------------------
W
I
T
--------
H
C
F
G
------
R
------
F
L
I
D
-
L
-
P
PD
A
V
I
N
-
A
G
-----------
Y
Y
L
W
GD
R
I
---
E
Y
L
----
D
D
K
P
T
E
----
L
A
A
R
-
V
D
R
L
E
Q
----
E
W
R
T
-----
Q
R
H
K
S
----
K
G
N
-----
M
F
------
L
R
-------------
K
I
D
--------
F
G
N
-----
E
S
----
V
G
L
--------------
L
S
W
S
S
E
---
V
A
---------------
S
K
T
Y
L
-------------
L
D
----------
T
Y
V
T
S
K
---
P
T
W
H
-------
V
Y
R
W
-------
K
G
K
V
---
S
V
D
R
E
-----
Q
H
A
V
E
I
S
R
-
A
L
A
R
N
-
L
R
S
-------
R
A
P
-------
K
E
--
I
P
S
E
P
G
----
F
C
I
DHA--
Y
I
A
G
D
S
F
Q
V
E
R
F
G
----
V
G
V
T
F
P
------
E
H
P
G
A
R
F
---
E
F
R
S
-----
S
T
G
A
E
L
N
S
L
-----
L
E
R
V
---
D
------
G
F
V
Q
N
M
L
S
T
F
-------------------------------------
A
G
--
M
E
T
L
R
K
---------------------------------
G
K
H
P
V
G
S
L
---------------------
P
G
E
E
Y
----
L
V
--
A
---------
G
--
S
D
K
G
Q
R
G
Y
T
F
M
W
---
E
V
--
Q
G
------------------------
K
E
-
E
S
L
T
E
P
-----------
N
L
T
A
G
L
------------
A
V
L
E
R
S
N
------
E
N
--------
G
K
P
-------------------------
P
P
------
P
A
F
K
--------------
S
----------
D
K
---
E
-----
A
L
-
E
L
W
D
T
I
V
D
S
I
--------
R
-
V
R
-
P
T
S
---------------
5
PsiBlast_PDB
54.30
28%
-18
- C2 -
4E0S
-
CO5_HUMAN
A:
[1258-1316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
L
N
L
K
D
I
--
N
Y
V
N
P
V
I
K
W
----
L
S
--
E
---------
E
--
Q
R
Y
G
G
G
F
Y
S
T
Q
D
T
I
N
A
I
--
E
G
L
T
E
Y
S
---------
L
-----
L
V
--
K
Q
-
L
R
L
S
M
D
I
D
V
S
Y
K
H
----
K
G
A
L
H
N
------------
Y
K
M
T
D
K
N
F
L
G
R
P
V
E
V
--------
L
L
N
-------------
D
---
D
L
I
V
S
T
G
F
G
S
------
G
L
A
T
--------------
V
H
V
T
--
T
V
V
-
H
K
T
---
S
-----
T
S
-
E
E
V
C
S
F
Y
L
K
I
--------
D
-
T
Q
-
D
I
E
D
Y
K
R
-----------
3
PsiBlast_PDB
47.86
28%
1
- C2 -
3KLS
-
CO5_HUMAN
A:
[1258-1316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
L
N
L
K
D
I
--
N
Y
V
N
P
V
I
K
W
----
L
S
--
E
---------
E
--
Q
R
Y
G
G
G
F
Y
S
T
Q
D
T
I
N
A
I
--
E
G
L
T
E
Y
S
---------
L
-----
L
V
--
K
Q
-
L
R
L
S
M
D
I
D
V
S
Y
K
H
----
K
G
A
L
H
N
------------
Y
K
M
T
D
K
N
F
L
G
R
P
V
E
V
--------
L
L
N
-------------
D
---
D
L
I
V
S
T
G
F
G
S
------
G
L
A
T
--------------
V
H
V
T
--
T
V
V
-
H
K
T
---
S
-----
T
S
-
E
E
V
C
S
F
Y
L
K
I
--------
D
-
T
Q
-
D
I
Y
K
R
I
V
-----------
2
PsiBlast_PDB
43.32
28%
16
- C2 -
3CU7
-
CO5_HUMAN
A:
[1258-1316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
L
N
L
K
D
I
--
N
Y
V
N
P
V
I
K
W
----
L
S
--
E
---------
E
--
Q
R
Y
G
G
G
F
Y
S
T
Q
D
T
I
N
A
I
--
E
G
L
T
E
Y
S
---------
L
-----
L
V
--
K
Q
-
L
R
L
S
M
D
I
D
V
S
Y
K
H
----
K
G
A
L
H
N
------------
Y
K
M
T
D
K
N
F
L
G
R
P
V
E
V
--------
L
L
N
-------------
D
---
D
L
I
V
S
T
G
F
G
S
------
G
L
A
T
--------------
V
H
V
T
--
T
V
V
-
H
K
T
---
S
-----
T
S
-
E
E
V
C
S
F
Y
L
K
I
--------
D
-
T
Q
-
D
I
Y
K
R
I
V
-----------
7
PsiBlast_PDB
42.15
28%
14
- C2 -
3PVM
-
CO5_HUMAN
A:
[1258-1316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
L
N
L
K
D
I
--
N
Y
V
N
P
V
I
K
W
----
L
S
--
E
---------
E
--
Q
R
Y
G
G
G
F
Y
S
T
Q
D
T
I
N
A
I
--
E
G
L
T
E
Y
S
---------
L
-----
L
V
--
K
Q
-
L
R
L
S
M
D
I
D
V
S
Y
K
H
----
K
G
A
L
H
N
------------
Y
K
M
T
D
K
N
F
L
G
R
P
V
E
V
--------
L
L
N
-------------
D
---
D
L
I
V
S
T
G
F
G
S
------
G
L
A
T
--------------
V
H
V
T
--
T
V
V
-
H
K
T
---
S
-----
T
S
-
E
E
V
C
S
F
Y
L
K
I
--------
D
-
T
Q
-
D
I
E
S
D
Y
K
-----------
8
PsiBlast_PDB
41.57
28%
22
- C2 -
4A5W
-
CO5_HUMAN
A:
[1162-1220]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
L
N
L
K
D
I
--
N
Y
V
N
P
V
I
K
W
----
L
S
--
E
---------
E
--
Q
R
Y
G
G
G
F
Y
S
T
Q
D
T
I
N
A
I
--
E
G
L
T
E
Y
S
---------
L
-----
L
V
--
K
Q
-
L
R
L
S
M
D
I
D
V
S
Y
K
H
----
K
G
A
L
H
N
------------
Y
K
M
T
D
K
N
F
L
G
R
P
V
E
V
--------
L
L
N
-------------
D
---
D
L
I
V
S
T
G
F
G
S
------
G
L
A
T
--------------
V
H
V
T
--
T
V
V
-
H
K
T
---
S
-----
T
S
-
E
E
V
C
S
F
Y
L
K
I
--------
D
-
T
Q
-
D
I
Y
K
R
I
V
-----------
4
PsiBlast_PDB
40.41
28%
-2
- C2 -
3KM9
-
CO5_HUMAN
A:
[1258-1316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
L
N
L
K
D
I
--
N
Y
V
N
P
V
I
K
W
----
L
S
--
E
---------
E
--
Q
R
Y
G
G
G
F
Y
S
T
Q
D
T
I
N
A
I
--
E
G
L
T
E
Y
S
---------
L
-----
L
V
--
K
Q
-
L
R
L
S
M
D
I
D
V
S
Y
K
H
----
K
G
A
L
H
N
------------
Y
K
M
T
D
K
N
F
L
G
R
P
V
E
V
--------
L
L
N
-------------
D
---
D
L
I
V
S
T
G
F
G
S
------
G
L
A
T
--------------
V
H
V
T
--
T
V
V
-
H
K
T
---
S
-----
T
S
-
E
E
V
C
S
F
Y
L
K
I
--------
D
-
T
Q
-
D
I
Y
K
R
I
V
-----------
6
PsiBlast_PDB
39.97
28%
16
- C2 -
3PRX
-
CO5_HUMAN
A:
[1258-1316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
L
N
L
K
D
I
--
N
Y
V
N
P
V
I
K
W
----
L
S
--
E
---------
E
--
Q
R
Y
G
G
G
F
Y
S
T
Q
D
T
I
N
A
I
--
E
G
L
T
E
Y
S
---------
L
-----
L
V
--
K
Q
-
L
R
L
S
M
D
I
D
V
S
Y
K
H
----
K
G
A
L
H
N
------------
Y
K
M
T
D
K
N
F
L
G
R
P
V
E
V
--------
L
L
N
-------------
D
---
D
L
I
V
S
T
G
F
G
S
------
G
L
A
T
--------------
V
H
V
T
--
T
V
V
-
H
K
T
---
S
-----
T
S
-
E
E
V
C
S
F
Y
L
K
I
--------
D
-
T
Q
-
D
I
E
S
D
Y
K
-----------
12
HHSearch
39.14
9%
-154
- C2 -
2XQ2
2
SGLT_VIBPH
A:
[51-201]
------------------------------------------------------------------------------------------------------------------------------
L
P
W
W
A
V
G
A
--------
S
L
I
A
------
A
N
I
--
S
A
E
Q
F
I
-
G
M
S
---
G
S
G
-
Y
S
-----------
I
G
L
A
--
I
A
----
S
Y
----
E
W
M
S
A
I
----
T
L
I
I
-
V
G
K
Y
F
L
----
P
I
F
I
-----
E
K
G
I
Y
----
T
I
P
-----
E
F
------
V
E
-------------
K
R
---------
F
N
K
-----
K
L
-
K
T
I
L
A
V
--------------
F
W
I
S
L
Y
I
--
F
V
N
L
T
S
V
--------
L
Y
L
G
G
L
A
-------------
L
E
----------
T
I
L
G
----
I
P
--
L
M
Y
S
I
L
G
L
A
L
F
A
-------
L
V
Y
S
---
I
Y
G
G
--------
V
V
W
T
D
V
-
I
Q
V
F
F
-
L
V
L
G
G
---
F
M
T
T
Y
-------
M
A
--
V
S
F
I
G
G
----
T
D
G
-----
W
F
A
-
G
V
S
K
M
V
D
A
A
----
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
Y
M
N
L
P
---
G
I
A
V
-----
L
I
G
G
L
W
V
A
N
-----
L
Y
Y
W
---
G
------
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
--
S
E
A
Q
K
--------------
G
I
V
--
F
A
A
F
L
-
A
L
--
I
V
P
F
L
V
---------------------------------
V
L
P
G
I
A
A
Y
V
I
T
S
-----
D
P
Q
L
M
A
--
S
L
G
N
L
P
S
A
A
----
N
A
--
D
---------
K
--
A
Y
P
W
L
T
Q
F
L
P
V
G
---
V
K
--
G
V
V
F
A
A
L
---------
A
-----
A
A
--
I
V
-
S
S
L
A
S
M
L
N
S
T
A
T
I
----
F
T
M
D
I
Y
------------
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
--------
V
G
R
-------------
T
---
A
A
V
V
A
L
I
I
A
A
------
L
I
A
P
--------------
M
L
G
G
--
I
G
Q
-
C
F
Q
---
Y
-----
I
Q
-
E
Y
T
G
L
V
S
P
G
I
--------
L
-
A
V
-
F
L
L
G
L
F
W
-----------
13
HHSearch
32.68
10%
-134
- C2 -
2JLN
1
?
A:
[60-183]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
---
I
V
A
----
I
A
A
G
C
T
----
I
A
V
I
-
L
L
F
F
T
Q
----
S
A
A
I
-----
R
W
G
-
I
----
N
F
T
-----
V
A
------
A
R
-------------
M
P
---------
F
G
I
-----
R
G
-
S
L
I
P
I
T
--------------
L
K
A
L
L
S
---
L
F
W
F
G
F
Q
--------
T
W
L
G
A
L
A
-------------
L
D
----------
E
I
T
R
L
L
T
G
F
--
T
N
L
P
L
W
I
V
I
F
G
A
I
-------
Q
V
V
T
---
T
F
Y
G
I
-----
T
F
I
R
W
M
N
V
-
F
A
S
P
V
-
L
L
A
M
G
---
V
Y
M
V
Y
-------
L
M
--
L
D
G
A
D
V
----
S
L
G
-----
E
V
M
-
S
M
G
G
E
N
P
G
M
----
P
F
S
T
A
I
M
I
F
V
G
G
W
I
A
V
V
V
S
---
I
H
D
I
-----
V
K
E
C
K
V
D
P
N
-----
A
S
R
E
---
G
------
Q
T
K
A
D
A
R
Y
A
T
A
Q
W
L
G
--
M
V
P
A
S
--------------
I
I
F
--
G
F
I
G
A
-
A
S
--
M
V
L
V
G
E
---------------------------------
W
N
P
V
I
A
I
T
E
V
V
G
-----
G
V
S
I
P
M
--
A
I
L
F
Q
V
F
V
L
----
L
A
--
T
---------
W
--
S
T
N
P
A
A
N
L
L
S
P
A
---
Y
T
--
L
C
S
T
F
P
R
---------
V
-----
F
T
--
F
K
-
T
G
V
I
V
S
A
V
V
G
L
L
M
----
M
P
W
Q
F
A
------------
G
V
L
N
T
F
L
N
L
L
A
S
A
L
G
--------
P
L
A
-------------
G
---
I
M
I
S
D
Y
F
L
V
R
------
R
R
R
I
--------------
S
L
H
D
--
L
Y
R
-
T
K
G
---
I
-----
Y
T
-
Y
W
R
G
V
N
W
V
A
L
--------
A
-
V
Y
-
A
V
A
L
A
V
S
-----------
1
PsiBlast_PDB
32.03
48%
-139
- C2 -
3O8O
-
PFKA1_YEAST
A:
[204-230]
-----------------------------------------------------------------------------------------------------------------------------------
W
L
A
--------
L
M
A
G
------
I
A
T
--
G
A
D
Y
I
F
-
I
-
P
---
E
R
A
-
V
P
-----------
H
G
K
W
--
Q
D
---
E
L
K
----
E
V
C
Q
R
H
----
R
S
K
G
-
R
R
N
N
T
I
----
I
V
A
E
-----
G
A
L
D
D
----
Q
L
N
-----
P
V
------
T
A
-------------
N
D
---------
V
K
D
-----
A
L
-
I
E
L
G
L
D
--------------
T
K
V
T
I
L
---
G
H
V
Q
R
G
G
--------
T
A
V
A
H
D
R
-------------
W
L
----------
A
T
L
Q
G
V
D
A
V
K
A
V
L
E
F
T
P
E
T
P
S
P
L
I
-------
G
I
L
E
---
N
K
I
I
R
-----
M
P
L
V
E
S
V
K
-
L
T
K
S
V
-
A
T
A
I
E
---
N
K
D
F
D
-------
K
A
--
I
S
L
R
D
T
----
E
F
I
-----
E
L
Y
-
E
N
F
L
S
T
T
V
K
----
D
D
G
S
E
L
L
P
V
S
D
R
L
N
I
G
I
V
H
---
V
G
A
P
-----
S
A
A
L
N
A
A
T
R
-----
A
A
T
L
---
Y
------
C
L
S
H
G
H
K
P
Y
A
I
M
N
G
F
--
S
G
L
I
Q
--------------
T
G
E
--
V
K
E
L
S
-
W
I
--
D
V
E
N
W
H
---------------------------------
N
L
G
G
S
E
I
G
T
N
R
S
-----
V
A
S
E
D
L
--
G
T
I
A
Y
Y
F
Q
K
----
N
K
--
L
---------
D
--
G
L
I
I
L
G
G
F
E
G
F
R
---
S
L
--
K
Q
L
R
D
G
R
---------
T
-----
Q
H
--
P
I
-
F
N
I
P
M
C
L
I
P
A
T
V
S
----
N
N
V
P
G
T
------------
E
Y
S
L
G
V
D
T
C
L
N
A
L
V
N
--------
Y
T
D
-------------
D
---
I
K
Q
S
A
S
A
T
R
R
------
R
V
F
V
--------------
C
E
V
Q
--
G
G
H
-
S
G
Y
---
I
-----
A
S
-
F
T
G
L
I
T
G
A
V
S
--------
V
-
Y
T
-
P
E
K
K
I
D
L
-----------