@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0213: (2015-12-13 )
MLEKIQKEWLSNIQKDLLSGFVVGLSVIPETAGFAIMVGLDVGVAFYTTFYMAFVLSLFGARKAMISAAAGSVALILVGVVKNYGLEYAGVATLMAGILQILLGYLKIGNLLKFIPQSVMYGFVNALGILLLTEQFKFLQNQNLGVFVLLAIGILIIYLFPLITKKIPSNLICILAVSAIALIFDTHAPNLGSIEQGVSGFHFIIIPKNLDFKMVLGLLPYALSLALVGTIESLLTAKTLDVILKDGVSDKNKETKAQGLGNIISGLLGGMTGCALVGQSIINAKSGAKTRLSTFFAGFSLMVLILVFNEYVVKIPIVAVVAVMVIISFTTFNFQSIMNIKTIKLYDTLNMLLVVAVVLYTHNLAIGVVVGVLINALWIKFKGMG
Atome Classification :
(18 SA)
-------------.........--10........20.......-----.30.......--.40........50........-60......-.-.70......---------..80........--------------90........100.----...----...110--...-.....-.120.--..-------....130.......-------140-------.......-150------........160...---...-----.-170..------....-.180...-....---190....-...200........210.......--220.......230.......240...----------.---...-250--........260.....-----------..270.......-280.......290----.......300.....--------..310.......320...-------...-.330..-.....340..-----.-....350.......-----------360-------------.......370-........380...-------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------
M
L
E
K
I
Q
K
E
W
--
L
S
N
I
Q
K
D
L
L
S
G
F
V
V
G
L
S
VI-----PETA
G
F
A
I
M
V
--
G
LD
V
G
V
A
F
Y
T
T
F
Y
M
A
F
V
L
S
L
F
-
G
A
R
K
A
M
I
S
-A-AAG
S
V
A
L
I
L
---------
V
G
V
V
K
NYGL
E
Y
A
--------------
G
V
A
T
L
M
A
G
I
L
Q
I
L
L
----
G
Y
L
----
K
I
G
N
----
L
L
K
-
F
I
P
Q
S
-
V
M
Y
G
F
--
V
N
-------
A
L
G
I
L
L
L
T
E
Q
F
K
F
L
-------QNQ-------N
L
G
V
F
V
L
-
L
A
-------
I
G
I
L
I
I
Y
L
F
P
L
I
T
K
---KIP-----S-
N
L
I
C
I
------
L
A
V
S
-
A
I
A
L
I
FD-THAP---NL
G
S
I
E
Q-GVSG
F
-
H
F
I
I
IPKNL
D
F
K
M
V
L
G
L
L
--
P
Y
A
L
S
L
A
L
V
G
T
I
E
S
L
L
T
A
K
T
L
D
V
I
L
K----------D---GVS-DK---N
K
E
T
K
A
Q
G
L
G
N
I
I
S
G
L
-----------LGG
M
T
G
C
A
L
V
G
Q
-
S
I
INAKSGA
K
T
R
L
----
S
T
F
F
A
G
F
S
L
M
V
L
I
L
V
--------
F
N
E
Y
V
V
K
I
P
I
V
A
V
V
A
V
M
V
-------
I
I
S-FTTF
N
F
-
Q
S
I
M
N
I
K
T
I
K
-----
L
-
Y
D
T
L
N
M
L
L
V
V
A
V
V
L
-----------
Y
TH-------------N
L
A
I
G
V
V
V
G
--
V
L
I
N
A
L
W
I
K
F
KGMG-------------------------------------------------------------------------------------------
12
Fugue
95.09
42%
-145
- C6 -
5DA0
2
?
A:
[14-484]
------------------
Q
R
E
W
--
F
A
N
P
R
K
D
V
L
A
G
I
V
V
A
L
A
L
I
-----
P
E
A
I
A
F
S
I
I
A
--
G
V
D
P
Q
V
G
L
Y
A
S
F
I
I
A
L
I
T
A
F
L
-
G
G
R
P
G
M
I
S
-
A
-
A
T
G
A
M
A
L
L
M
---------
T
G
L
V
K
D
H
G
I
Q
Y
L
--------------
F
A
A
T
V
L
T
G
V
L
Q
V
V
F
----
G
W
A
----
K
L
A
R
----
Y
L
K
-
F
V
P
R
S
-
V
M
V
G
F
--
V
N
-------
A
L
A
I
L
I
F
M
A
Q
L
P
Q
F
-------
V
G
A
-------
N
W
Q
M
Y
A
M
-
V
A
-------
A
G
L
A
I
I
Y
L
L
P
L
V
F
K
---
A
M
P
-----
S
-
A
L
V
A
I
------
V
V
L
T
-
V
V
A
V
V
T
G
-
A
D
V
K
---
T
V
G
D
M
G
T
-
L
P
T
A
L
P
H
F
Q
F
P
Q
V
P
L
T
F
E
T
L
A
I
I
F
--
P
V
A
L
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
E
R
-
T
----------
D
---
T
T
S
-
D
K
---
N
V
E
S
R
G
Q
G
V
A
N
I
V
T
G
F
-----------
F
G
G
M
A
G
C
A
M
I
G
Q
-
S
M
I
N
V
T
S
G
G
R
G
R
L
----
S
T
F
V
A
G
A
F
L
M
V
L
I
L
A
--------
L
Q
P
L
L
V
Q
I
P
M
A
A
L
V
A
V
M
M
-------
V
V
A
-
I
S
T
F
D
W
-
G
S
L
----
R
F
P
-----
K
-
G
E
T
V
V
M
L
A
T
V
A
V
T
V
-----------
F
T
H
-------------
D
L
S
L
G
V
L
I
G
--
V
V
L
S
A
L
F
F
A
R
K
V
S
Q
L
S
Q
V
T
P
V
D
E
VDG
T
R
T
Y
R
V
R
G
Q
LFFVS
T
H
D
F
L
H
Q
F
DFTHPAR
R
V
V
I
D
LSD
A
H
F
WD
G
S
A
V
G
A
L
D
K
V
M
L
K
F
M
R
Q
G
T
S
V
E
L
R
GL
N
A
A
S
A
T
LVERL
1
PsiBlast_PDB
94.53
41%
-145
* C6 *
5DA0
2
?
A:
[14-390]
------------------
Q
R
E
W
--
F
A
N
P
R
K
D
V
L
A
G
I
V
V
A
L
A
L
I
-----
P
E
A
I
A
F
S
I
I
A
--
G
V
D
P
Q
V
G
L
Y
A
S
F
I
I
A
L
I
T
A
F
L
-
G
G
R
P
G
M
I
S
-
A
-
A
T
G
A
M
A
L
L
M
---------
T
G
L
V
K
D
H
G
I
Q
Y
L
--------------
F
A
A
T
V
L
T
G
V
L
Q
V
V
F
----
G
W
A
----
K
L
A
R
----
Y
L
K
-
F
V
P
R
S
-
V
M
V
G
F
--
V
N
-------
A
L
A
I
L
I
F
M
A
Q
L
P
Q
F
-------
V
G
A
-------
N
W
Q
M
Y
A
M
-
V
A
-------
A
G
L
A
I
I
Y
L
L
P
L
V
F
K
---
A
M
P
-----
S
-
A
L
V
A
I
------
V
V
L
T
-
V
V
A
V
V
T
G
-
A
D
V
K
TVG
D
M
G
T
L
P
T
-
A
L
P
H
F
-
Q
F
P
Q
V
P
--
L
T
F
E
T
L
A
I
I
F
--
P
V
A
L
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
E
-
R
T
----------
D
---
T
T
S
-
D
K
---
N
V
E
S
R
G
Q
G
V
A
N
I
V
T
G
F
-----------
F
G
G
M
A
G
C
A
M
I
G
Q
-
S
M
I
N
V
T
S
G
G
R
G
R
L
----
S
T
F
V
A
G
A
F
L
M
V
L
I
L
A
--------
L
Q
P
L
L
V
Q
I
P
M
A
A
L
V
A
V
M
M
-------
V
V
A
-
I
S
T
F
D
W
-
G
S
L
R
----
F
P
-----
K
-
G
E
T
V
V
M
L
A
T
V
A
V
T
V
-----------
F
T
H
-------------
D
L
S
L
G
V
L
I
G
--
V
V
L
S
A
L
F
F
A
R
K
V
S
Q
-------------------------------------------------------------------------------------------
18
Fugue
68.17
14%
-128
- C6 -
3QE7
2
URAA_ECOLI
A:
[4-410]
---------RAIG
V
S
E
R
P
P
L
L
Q
--
T
I
P
L
S
L
Q
H
L
F
A
M
F
G
A
T
V
L
V
-----
P
V
------
L
F
--
H
I
N
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
F
I
-
C
K
G
K
I
P
A
Y
-
L
-
G
S
S
F
A
F
I
S
P
---------
V
L
L
L
L
P
L
G
Y
E
V
A
--------------
L
G
G
F
I
M
C
G
V
L
F
C
L
V
----
S
F
I
----
V
K
K
A
GT
G
W
L
D
V
-
L
F
P
P
A
-
A
M
G
A
I
--
V
A
-------
V
I
G
L
E
L
A
G
V
A
A
G
M
A
GLLPAEG
Q
T
P
-------
D
S
K
T
I
I
I
-
S
I
-------
T
T
L
A
V
T
V
L
G
S
V
L
F
R
---
G
F
L
-----
A
I
I
P
I
L
I
------
G
V
L
V
-
G
Y
A
L
S
F
A
-
M
G
I
V
---
D
T
T
P
I
I
N
-
A
-----
H
W
F
A
L
P
T
L
Y
T
P
R
F
E
W
F
A
I
--
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
----------
K
---
D
L
L
-
R
D
PG
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
-----------
F
G
S
T
P
N
T
T
Y
--
G
-
E
N
I
G
V
M
A
I
T
R
V
Y
S
----
T
W
V
I
G
G
A
A
I
F
A
I
L
L
S
--------
C
V
G
K
L
A
A
A
I
Q
M
I
P
L
P
V
M
G
-------
G
V
S
-
L
L
L
Y
G
V
-
I
G
A
S
G
I
R
V
L
I
E
SKVD
Y
-
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
-----------
I
G
V
S
GAKVNIGAAELK
G
M
A
L
A
T
I
V
G
--
I
G
L
S
L
I
F
K
L
I
S
----------------------------------------------------------------------------------------------
2
HHSearch
62.81
13%
-116
- C6 -
3QE7
2
URAA_ECOLI
A:
[6-410]
-----------------
I
G
V
S
E
--
R
P
P
L
L
Q
T
I
P
L
S
L
Q
H
L
F
A
M
F
-----
G
A
T
V
L
V
P
V
L
F
--
H
I
N
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
F
I
C
K
G
K
I
P
A
Y
L
-
G
-
S
S
F
A
F
I
S
P
V
---------
L
L
L
L
-
P
L
G
Y
E
V
A
--------------
L
G
G
F
I
M
C
G
V
L
F
C
L
V
----
S
F
I
V
K
K
A
G
T
G
W
----
L
D
V
-
L
F
P
P
A
-
A
M
G
A
I
--
V
A
-------
V
I
G
L
E
L
A
G
V
A
A
G
M
A
-------
G
L
L
PAEGQTP
D
S
K
T
I
I
I
-
S
I
-------
T
T
L
A
V
T
V
L
G
S
V
L
F
R
GFL
A
I
I
-----
P
-
I
L
I
G
V
------
L
V
G
Y
-
A
L
S
F
A
M
G
I
V
D
T
T
---
P
I
I
N
A
H
W
F
A
L
P
T
L
-
Y
-----
T
P
-
R
F
E
--
W
F
A
I
--
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
----------
K
DLL
R
D
P
-
G
L
---
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
-----------
F
G
S
T
P
N
T
T
Y
G
E
N
-
I
G
V
M
A
I
T
R
V
Y
S
T
W
----
V
I
G
G
A
A
I
F
A
I
L
L
S
C
V
G
K
------
L
A
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
-
I
R
V
L
I
E
-
S
K
V
D
Y
-
N
--
K
-----
A
-
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
GAKVNIGAAE
L
K
--------------
G
M
A
L
A
T
I
V
G
--
I
G
L
S
L
I
F
K
L
I
S
----------------------------------------------------------------------------------------------
21
Fugue
61.55
18%
-148
- C2 -
4XGC
1
ORC5_DROME
E:
[1-458]
--------------
M
E
A
I
C
S
S
L
E
P
L
F
P
C
R
E
A
A
I
E
T
L
G
E
L
I
G
D
S
-----
S
E
T
Y
P
S
A
I
Y
L
F
G
H
S
G
T
G
K
T
A
L
T
R
A
F
L
K
E
C
G
K
R
Q
-
N
V
R
T
A
H
L
N
-
A
---------------------------
I
E
C
Y
--------------
T
T
K
I
M
L
E
I
L
L
D
S
L
A
PDQG
D
A
L
----
K
V
D
N
----
M
L
D
-
F
V
E
Q
L
-
R
R
Q
A
A
TR
V
E
-------
D
Q
G
F
L
I
A
V
D
N
A
E
R
L
-------
R
D
M
-------
D
A
N
V
L
P
V
-
L
L
R
LQELTN
L
N
L
C
V
I
L
L
S
Q
L
P
F
E
---
K
F
Y
NK
T
G
L
S
-
E
I
V
C
L
H
L
A
Q
YN
K
A
E
T
-
Q
R
I
L
G
S
D
-
F
Q
Q
V
---
R
N
Q
L
L
E
Q
-
K
K
R
L
E
-
I
C
Q
E
A
V
T
E
D
F
Y
N
N
Y
L
N
L
F
--
L
S
V
F
Y
K
A
C
R
D
V
P
E
L
Q
L
T
A
R
K
C
L
S
T
Y
L
----------
E
---
P
V
L
-
D
G
---
T
S
R
L
W
R
H
I
A
G
P
L
R
S
A
L
T
Q
IYMRIES
L
E
L
P
Y
Y
A
K
F
L
L
I
A
A
-
F
L
A
S
H
N
A
A
K
Q
D
K
R
LFST
T
L
G
P
K
S
F
S
I
D
R
L
L
A
I
--------
F
Y
A
I
L
E
E
K
V
G
L
T
C
N
L
L
S
Q
-------
I
S
T
-
L
V
H
L
N
L
-
L
S
F
V
S
G
E
Q
N
I
-----
M
-
E
G
S
A
R
L
Q
C
T
I
G
L
--------------
E
F
-------------
V
L
Q
I
G
K
V
V
G
--
F
N
V
R
Q
Y
L
C
D
------------------------------------------------------------------------------------------------
15
Fugue
56.74
14%
-130
* C5 *
1A6Q
3
PPM1A_HUMAN
A:
[2-368]
-----------GA
F
L
D
K
P
K
M
E
K
--
H
N
A
Q
G
Q
G
--
N
G
L
R
Y
G
L
S
S
M
QGWRV
E
M
E
D
A
H
T
A
V
I
--
G
L
P
S
G
L
E
S
W
S
F
F
A
V
Y
D
G
H
A
---
G
S
Q
V
A
K
Y
C
-
C
-
E
H
L
L
D
H
I
T
N
---------
N
Q
D
F
K
G
S
A
G
A
-
P
--------------
S
V
E
N
V
K
N
G
I
R
T
G
F
L
----
E
I
D
----
E
H
M
R
----
V
M
S
-
E
K
K
H
G
-
A
D
R
S
G
--
S
T
-------
A
V
G
V
L
I
S
P
Q
H
T
Y
F
I
-------
N
C
G
-------
D
-
S
R
G
L
L
-
C
R
-------
N
R
K
V
H
F
F
T
Q
---
D
H
---
K
P
S
-----
N
-
P
L
E
K
E
------
R
I
Q
N
-
A
G
G
S
V
M
I
-
Q
R
V
N
---
G
S
L
A
V
S
R
-
A
L
G
D
F
-
D
Y
K
C
V
H
G
K
G
P
T
E
Q
L
V
S
P
E
--
P
------
E
V
H
D
I
E
R
S
E
E
D
D
Q
F
I
I
L
A
C
----------
D
---
G
I
W
-
D
V
------
M
G
N
E
E
L
C
D
F
V
R
S
R
-----------
L
E
V
T
D
D
L
E
K
V
C
N
-
E
V
V
D
T
C
L
Y
K
G
S
R
D
----
N
--------
M
S
V
I
L
I
--------
C
F
P
N
A
P
K
V
S
P
E
A
V
K
K
E
A
E
-------
L
D
K
-
Y
L
E
C
R
V
-
E
E
I
I
K
----
G
-----
V
-
P
D
L
V
H
V
M
R
T
L
A
S
E
N
-----------
I
P
S
-------------
L
P
P
G
G
E
L
A
S
K
R
N
V
I
E
A
V
Y
N
R
L
N
P
Y
--------------------------------------------------------------------------------------------
19
Fugue
52.21
16%
-138
- C4 -
4PW8
1
T23O_HUMAN
A:
[26-367]
-----------------
I
Y
G
N
Y
--
L
-
H
L
E
K
V
L
N
A
Q
-----
E
L
Q
-----
S
E
T
K
G
N
K
I
----------------------------------------
H
D
E
H
L
F
---------
I
I
T
H
Q
A
Y
E
L
W
F
K
--------------
Q
I
L
W
E
L
D
S
V
R
E
I
F
Q
----
N
G
H
----
V
R
D
E
----
R
N
M
-
L
K
V
V
S
-
R
M
H
R
V
--
S
V
-------
I
L
K
L
L
V
Q
--
Q
F
S
I
L
-------
E
T
M
-------
T
-----
A
-
L
D
-------
F
N
D
F
R
E
Y
L
S
P
---
A
---
S
G
F
-----
Q
-
S
L
Q
F
R
------
L
L
E
N
-
K
I
G
V
L
Q
E
-
E
N
E
L
---
L
L
K
S
E
Q
E
-
K
T
----
L
L
E
L
V
E
A
W
L
E
R
T
P
G
L
E
P
H
--
G
F
N
F
W
G
K
L
E
K
N
I
T
R
G
L
E
E
E
F
I
R
I
Q
A
K
----------
E
-----
E
-
S
E
---
E
K
E
E
Q
V
A
E
F
Q
K
Q
K
E
V
L
-----------
L
S
------
L
F
D
E
-
K
R
H
E
H
L
L
S
K
G
E
R
R
----
L
S
Y
R
A
L
Q
G
A
L
M
I
Y
F
Y
--------
R
E
E
P
R
F
Q
V
P
F
Q
L
L
T
S
L
M
D
-------
I
D
S
L
M
T
K
W
R
Y
-
N
H
V
C
M
V
H
R
M
L
-----
G
-
S
R
Y
K
V
F
V
D
L
F
N
L
S
T
-----------
Y
---------------------------
L
I
P
R
H
W
I
P
K
M
N
---------------------------------------------------------------------------------------------
13
Fugue
48.90
17%
-128
- C6 -
4EWV
3
GH312_ARATH
A:
[14-581]
N
E
T
F
E
K
Q
L
K
D
L
TS
N
V
K
S
I
Q
D
N
L
--
L
E
E
I
I
T
P
D
K
E
L
F
K
K
N
V
S
Y
E
-----
D
I
K
P
Y
L
D
R
V
V
N-
G
E
S
Q
K
M
M
P
W
N
N
K
Y
L
D
N
L
T
F
I
Y
-
D
L
R
M
Q
V
I
T
-
K
-
H
V
K
G
V
E
M
M
F
L
F
T
K
QEPAR
V
A
T
S
S
Y
F
K
S
D
Y
F
K
N
RPSNWYYSYTSP
D
E
V
I
L
C
P
N
N
T
E
S
L
Y
----
C
H
L
----
L
C
G
L
----
V
Q
R
G
S
I
F
A
S
-
V
M
V
R
A
--
I
E
-------
V
L
K
N
S
W
-
E
E
L
C
S
N
I
-------
R
S
G
-------
H
L
S
N
W
V
T
D
L
G
-------
C
Q
N
S
V
S
L
V
L
G
G
P
R
P
---
E
L
A
-----
D
-
T
I
E
E
I
------
C
N
Q
N
-
S
W
K
G
I
V
K
-
R
L
W
P
---
N
T
K
Y
I
E
T
-
V
V
T
G
S
-
M
G
Q
Y
V
P
M
L
N
Y
Y
C
N
D
L
P
L
V
S
T
T
Y
G
S
S
E
T
T
F
G
I
N
L
D
P
L
-
C
K
P
E
D
V
S
Y
T
F
M
PNMSYFEF
I
---
G
C
T
-
Y
A
---
G
L
Y
R
M
R
V
G
D
I
V
L
V
T
G
F
-----------
Y
N
N
A
P
Q
F
K
F
V
R
R
E
N
V
V
L
S
I
D
S
D
K
T
N
E
----
E
D
L
F
K
A
V
S
Q
A
K
L
V
L
E
S
S
GLDLK
D
F
T
S
Y
A
D
T
S
T
F
P
G
H
Y
V
V
Y
L
-------
E
V
D
-
T
K
Q
F
E
L
D
E
E
A
L
S
T
C
C
L
V
-----
M
-
E
E
S
L
D
N
V
Y
K
R
C
R
F
K
-----------
D
G
S
IG-----------
P
L
E
I
R
V
V
R
Q
--
G
T
F
D
S
L
M
D
F
F
I
S
Q
G
ASTGQ
Y
K
T
P
RCIKSGKA
L
Q
V
L
E
T
C
VV
A
K
F
F
S
I-----------------------------------------------------------
17
Fugue
48.33
15%
-115
- C5 -
1T98
-
MUKF_ECOLI
A:
[8-281]
------------------------------------------
V
-----
P
E
L
V
A
W
A
R
K
N
--
D
F
S
I
S
L
---
P
V
D
R
L
S
F
L
L
A
V
A
-
T
L
N
G
E
R
L
D
G
E
M
S
E
G
E
L
V
D
A
F
---------
R
H
V
S
D
A
F
E
Q
T
S
E
--------------
T
I
G
V
R
A
N
N
A
I
N
------------------------------
D
M
V
R
Q
R
L
--
L
N
-------
R
F
T
I
Y
R
L
T
-----------------------------
P
-
L
G
-------
I
G
I
T
D
Y
Y
I
-----------
R
-----
Q
-
R
E
F
S
T
------
L
R
L
S
M
Q
L
S
I
V
A
G
-
E
L
K
R
---
A
A
D
A
A
E
E
-
G
G
D
E
F
-
H
W
H
R
N
--------
V
Y
A
P
L
--
K
Y
S
-------------
V
A
E
I
F
D
S
I
D
L
----------
T
---
Q
R
L
M
D
E
---
Q
Q
Q
Q
V
K
D
D
I
A
Q
L
L
N
K
-------------------------
D
W
R
A
A
I
S
S
C
E
L
L
L
----
S
E
T
S
G
T
L
R
E
L
Q
D
T
L
E
--------
A
A
G
D
K
L
Q
A
N
L
L
R
I
Q
D
A
-----------------------------------
T
M
T
H
D
D
L
H
F
V
D
R
L
V
F
D
-----------
L
Q
S
-------------
K
L
D
R
I
I
S
W
G
--
Q
Q
S
I
D
L
W
I
G
Y
D
R
H
V
-------------------------------------------------------------------------------------------
14
Fugue
40.97
40%
249
- C6 -
1F93
-
HNF1A_MOUSE
F:
[5-31]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
Q
L
Q
T
E
L
L
A
A
L
L
E
----------
S
---
G
L
S
-------
K
E
A
L
I
Q
A
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
32.84
25%
248
- C6 -
1F93
-
HNF1A_MOUSE
E:
[1-31]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
S
K
L
S
Q
L
Q
T
E
L
L
A
A
----------
L
---
L
E
S
-
G
L
---
S
K
E
A
L
I
Q
A
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
30.99
18%
547
- C6 -
3H3G
-
B:
[4-19]
-----------------
I
Q
D
L
R
--
R
R
F
F
L
H
H
L
I
A
E
I
H
T
A
N
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
27.51
12%
70
- C3 -
1KVD
-
TOXK_MILFA
A:
[5-38]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
R
M
Q
-----
K
-
S
T
T
I
A
A
I
A
G
C
S
G
A
A
-----------
T
F
--------------
G
G
L
A
G
G
I
V
G
--
C
I
A
A
G
I
L
A
I
L
Q
G
F
E
-------------------------------------------------------------------------------------------
8
HHSearch
27.08
16%
201
* C7 *
1FCQ
-
HUGA_APIME
A:
[93-123]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
L
I
N
Q
I
P
D
K
S
-------------
F
P
G
-
V
G
V
I
D
F
-
E
S
W
R
P
I
F
R
Q
N
-----
W
-
A
S
L
Q
P
Y
K
K
L
S
V
E
V
V
-----------
R
R
E
-------------
H
P
F
W
D
D
Q
R
V
--
E
Q
E
A
K
R
R
F
E
K
Y
G
Q
L
-------------------------------------------------------------------------------------------
3
HHSearch
26.83
22%
-77
- C6 -
3QE7
2
URAA_ECOLI
A:
[261-354]
-------------------------------------------------------------
P
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
-
G
S
T
P
N
T
T
Y
-
G
-
E
N
I
G
V
M
----------------
A
I
T
R
V
-
Y
S
--------------
T
W
V
I
G
G
A
A
I
F
A
I
L
L
----
S
C
V
G
---
K
L
A
A
----
A
I
Q
-
M
I
P
L
P
-
V
M
G
G
V
--
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
K
V
D
Y
-------
N
K
A
-------
Q
N
L
I
L
T
S
-
V
I
-------
L
I
I
G
V
S
G
A
K
V
N
I
G
A
---
A
E
L
-----
K
-
G
M
A
L
A
------
T
I
V
G
-
I
G
L
S
L
I
F
-
K
L
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
24.54
6%
223
- C7 -
2PE4
2
HYAL1_HUMAN
A:
[92-122]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
I
L
A
A
I
P
A
P
D
F
-------------
S
G
-
L
A
V
I
D
W
-
E
A
W
R
P
R
W
A
F
N
-----
W
-
D
T
K
D
I
Y
R
Q
R
S
R
A
L
V
-----------
Q
A
Q
-------------
H
P
D
W
P
A
P
Q
V
--
E
A
V
A
Q
D
Q
F
Q
G
A
A
R
A
-------------------------------------------------------------------------------------------
6
HHSearch
24.21
10%
229
- C7 -
2ATM
2
HUGAA_VESVU
A:
[90-117]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
D
K
I
Y
P
N
R
N
-------------
F
S
G
-
I
G
V
I
D
F
-
E
R
W
R
P
I
F
R
Q
N
-----
W
-
G
N
M
K
I
H
K
N
F
S
I
D
L
V
-----------
R
N
E
-------------
H
P
T
W
N
K
K
S
M
--
E
I
E
L
E
A
S
K
R
F
E
K
Y
A
-------------------------------------------------------------------------------------------
11
HHSearch
1.95
33%
2319
- C1 -
2K1K
-
EPHA1_HUMAN
A:
[554-559]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
L
L
G
--
A
--------------------------------------------------------------------------------------------------------