@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0295: (2015-12-14 )
MAKEILVAYGVDIDAVAGWLGSYGGEDSPDDISRGLFAGEVGIPRLLKLFKKYHLPATWFAPGHSIETFPEPMKMIVDAGHEVGAHGYSHENPIAMTAKQEEDVLLKSVELIKDLTGKAPTGYVAPWWEFSNITNELLLKHGFKYDHSLMHNDFTPYFVRVGDSWSKIDYSLEAKDWMKPLIRGVETNLVEIPANWYLDDLPPMMFIKKSPNSFGFVSPRDIGQMWIDQFDWVYREMDYAVFSMTIHPDVSARPQVLLMHEKIIEHINQHEGVRWVTFNEIADDFLKRNPRKK
Atome Classification :
(20 SA)
-------------------.........10......--..20-...----------------.---....30.-........40........50........60..-....-----.-.70....-....80........90......-..100...-....110.......120--.........130......-.---140.-.......150.......---160.......170.......180.......190.......200........210.......220.......230....-.--.--.240.-........250....-...260.......270.......-280.......290.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------MA
K
E
I
L
V
A
YGV
D
I
D
A
V
A
--
G
W
L
G
-SYG----------------G---ED
S
P
D
-
D
-
I
S
R
G
LFAGEV
G
I
P
R
L
L
K
L
F
K
K
YHLP
A
T
WFAPG-HSIE-----T-F
P
E
P
M
K
M
-
I
V
DAGHEVGAHGYSHEN
P
I
A
M
T-AKQ
E
E
D
V
L
-
L
K
S
V
E
L
I
K
D
L
TGKAP----TGYVAP
W
W
E
F
S
N
I
T
N
E
L
L
-
L
---
K
H-G-FKYD
H
S
L
M
HNDFT
P
Y
F
V
---
R
VGDSWSK
I
D
Y
SL
E
A
K
D
W
M
K
P
L
I
R
GVET
N
L
V
E
IPANWYLDD-LP
P
M
M
F
I
KKSPNSFGFV
S
P
R
D
I
G
Q
M
W
I
D
Q
F
D
W
V
Y
R
E-M--D--
Y
A
--
V
-
F
S
M
T
IHPDVSAR
P
Q
V
-
L
L
M
H
E
K
I
I
E
H
I
N
Q
HEG
V
R
W
V
T
F
N
-
E
I
A
D
D
F
L
KRNPRKK
23
PsiBlast_CBE
98.68
97%
-104
- C6 -
4LY4
1
PGDAE_HELPG
B:
[35-324]
--------------------
A
K
E
I
L
V
A
Y
G
V
D
I
D
A
V
A
--
G
W
L
G
-
S
Y
G
----------------
G
---
E
D
S
P
D
-
D
-
I
S
R
G
L
F
A
G
E
V
G
I
P
R
L
L
K
L
F
K
K
Y
H
L
P
A
T
W
F
V
P
G
-
H
S
I
E
-----
T
-
F
P
E
Q
M
K
M
-
I
V
D
A
G
H
E
V
G
A
H
G
Y
S
H
E
N
P
I
A
M
S
-
T
K
Q
E
E
D
V
L
-
L
K
S
V
E
L
I
K
D
L
T
G
K
A
P
----
T
G
Y
V
A
P
W
W
E
F
S
N
I
T
N
E
L
L
-
L
---
K
H
-
G
-
F
K
Y
D
H
S
L
M
H
N
D
F
T
P
Y
Y
V
---
R
V
G
D
S
W
S
K
I
D
Y
S
L
E
A
K
D
W
M
K
P
L
I
R
G
V
E
T
N
L
V
E
I
P
A
N
W
Y
L
D
D
-
L
P
P
M
M
F
I
K
K
S
P
N
S
F
G
F
V
S
P
R
D
I
G
Q
M
W
I
D
Q
F
D
W
V
Y
R
E
-
M
--
D
--
Y
A
--
V
-
F
S
M
T
I
H
P
D
V
S
A
R
P
Q
V
-
L
L
M
H
E
K
I
I
E
H
I
N
K
H
E
G
V
R
W
V
T
F
N
-
E
I
A
D
D
F
L
K
R
N
P
R
--
21
PsiBlast_CBE
98.38
97%
-103
- C6 -
4LY4
1
PGDAE_HELPG
D:
[35-324]
--------------------
A
K
E
I
L
V
A
Y
G
V
D
I
D
A
V
A
--
G
W
L
G
-
S
Y
G
----------------
G
---
E
D
S
P
D
-
D
-
I
S
R
G
L
F
A
G
E
V
G
I
P
R
L
L
K
L
F
K
K
Y
H
L
P
A
T
W
F
V
P
G
-
H
S
I
E
-----
T
-
F
P
E
Q
M
K
M
-
I
V
D
A
G
H
E
V
G
A
H
G
Y
S
H
E
N
P
I
A
M
S
-
T
K
Q
E
E
D
V
L
-
L
K
S
V
E
L
I
K
D
L
T
G
K
A
P
----
T
G
Y
V
A
P
W
W
E
F
S
N
I
T
N
E
L
L
-
L
---
K
H
-
G
-
F
K
Y
D
H
S
L
M
H
N
D
F
T
P
Y
Y
V
---
R
V
G
D
S
W
S
K
I
D
Y
S
L
E
A
K
D
W
M
K
P
L
I
R
G
V
E
T
N
L
V
E
I
P
A
N
W
Y
L
D
D
-
L
P
P
M
M
F
I
K
K
S
P
N
S
F
G
F
V
S
P
R
D
I
G
Q
M
W
I
D
Q
F
D
W
V
Y
R
E
-
M
--
D
--
Y
A
--
V
-
F
S
M
T
I
H
P
D
V
S
A
R
P
Q
V
-
L
L
M
H
E
K
I
I
E
H
I
N
K
H
E
G
V
R
W
V
T
F
N
-
E
I
A
D
D
F
L
K
R
N
P
R
--
22
PsiBlast_CBE
98.18
97%
-103
- C6 -
4LY4
1
PGDAE_HELPG
C:
[35-324]
--------------------
A
K
E
I
L
V
A
Y
G
V
D
I
D
A
V
A
--
G
W
L
G
-
S
Y
G
----------------
G
---
E
D
S
P
D
-
D
-
I
S
R
G
L
F
A
G
E
V
G
I
P
R
L
L
K
L
F
K
K
Y
H
L
P
A
T
W
F
V
P
G
-
H
S
I
E
-----
T
-
F
P
E
Q
M
K
M
-
I
V
D
A
G
H
E
V
G
A
H
G
Y
S
H
E
N
P
I
A
M
S
-
T
K
Q
E
E
D
V
L
-
L
K
S
V
E
L
I
K
D
L
T
G
K
A
P
----
T
G
Y
V
A
P
W
W
E
F
S
N
I
T
N
E
L
L
-
L
---
K
H
-
G
-
F
K
Y
D
H
S
L
M
H
N
D
F
T
P
Y
Y
V
---
R
V
G
D
S
W
S
K
I
D
Y
S
L
E
A
K
D
W
M
K
P
L
I
R
G
V
E
T
N
L
V
E
I
P
A
N
W
Y
L
D
D
-
L
P
P
M
M
F
I
K
K
S
P
N
S
F
G
F
V
S
P
R
D
I
G
Q
M
W
I
D
Q
F
D
W
V
Y
R
E
-
M
--
D
--
Y
A
--
V
-
F
S
M
T
I
H
P
D
V
S
A
R
P
Q
V
-
L
L
M
H
E
K
I
I
E
H
I
N
K
H
E
G
V
R
W
V
T
F
N
-
E
I
A
D
D
F
L
K
R
N
P
R
--
26
PsiBlast_CBE
97.65
97%
-103
- C6 -
3QBU
1
PGDAE_HELPG
B:
[35-324]
--------------------
A
K
E
I
L
V
A
Y
G
V
D
I
D
A
V
A
--
G
W
L
G
-
S
Y
G
----------------
G
---
E
D
S
P
D
-
D
-
I
S
R
G
L
F
A
G
E
V
G
I
P
R
L
L
K
L
F
K
K
Y
H
L
P
A
T
W
F
V
P
G
-
H
S
I
E
-----
T
-
F
P
E
Q
M
K
M
-
I
V
D
A
G
H
E
V
G
A
H
G
Y
S
H
E
N
P
I
A
M
S
-
T
K
Q
E
E
D
V
L
-
L
K
S
V
E
L
I
K
D
L
T
G
K
A
P
----
T
G
Y
V
A
P
W
W
E
F
S
N
I
T
N
E
L
L
-
L
---
K
H
-
G
-
F
K
Y
D
H
S
L
M
H
N
D
F
T
P
Y
Y
V
---
R
V
G
D
S
W
S
K
I
D
Y
S
L
E
A
K
D
W
M
K
P
L
I
R
G
V
E
T
N
L
V
E
I
P
A
N
W
Y
L
D
D
-
L
P
P
M
M
F
I
K
K
S
P
N
S
F
G
F
V
S
P
R
D
I
G
Q
M
W
I
D
Q
F
D
W
V
Y
R
E
-
M
--
D
--
Y
A
--
V
-
F
S
M
T
I
H
P
D
V
S
A
R
P
Q
V
-
L
L
M
H
E
K
I
I
E
H
I
N
K
H
E
G
V
R
W
V
T
F
N
-
E
I
A
D
D
F
L
K
R
N
P
R
--
25
PsiBlast_CBE
97.61
97%
-102
- C6 -
3QBU
1
PGDAE_HELPG
C:
[35-324]
--------------------
A
K
E
I
L
V
A
Y
G
V
D
I
D
A
V
A
--
G
W
L
G
-
S
Y
G
----------------
G
---
E
D
S
P
D
-
D
-
I
S
R
G
L
F
A
G
E
V
G
I
P
R
L
L
K
L
F
K
K
Y
H
L
P
A
T
W
F
V
P
G
-
H
S
I
E
-----
T
-
F
P
E
Q
M
K
M
-
I
V
D
A
G
H
E
V
G
A
H
G
Y
S
H
E
N
P
I
A
M
S
-
T
K
Q
E
E
D
V
L
-
L
K
S
V
E
L
I
K
D
L
T
G
K
A
P
----
T
G
Y
V
A
P
W
W
E
F
S
N
I
T
N
E
L
L
-
L
---
K
H
-
G
-
F
K
Y
D
H
S
L
M
H
N
D
F
T
P
Y
Y
V
---
R
V
G
D
S
W
S
K
I
D
Y
S
L
E
A
K
D
W
M
K
P
L
I
R
G
V
E
T
N
L
V
E
I
P
A
N
W
Y
L
D
D
-
L
P
P
M
M
F
I
K
K
S
P
N
S
F
G
F
V
S
P
R
D
I
G
Q
M
W
I
D
Q
F
D
W
V
Y
R
E
-
M
--
D
--
Y
A
--
V
-
F
S
M
T
I
H
P
D
V
S
A
R
P
Q
V
-
L
L
M
H
E
K
I
I
E
H
I
N
K
H
E
G
V
R
W
V
T
F
N
-
E
I
A
D
D
F
L
K
R
N
P
R
--
24
PsiBlast_CBE
97.58
97%
-102
- C6 -
3QBU
1
PGDAE_HELPG
D:
[35-324]
--------------------
A
K
E
I
L
V
A
Y
G
V
D
I
D
A
V
A
--
G
W
L
G
-
S
Y
G
----------------
G
---
E
D
S
P
D
-
D
-
I
S
R
G
L
F
A
G
E
V
G
I
P
R
L
L
K
L
F
K
K
Y
H
L
P
A
T
W
F
V
P
G
-
H
S
I
E
-----
T
-
F
P
E
Q
M
K
M
-
I
V
D
A
G
H
E
V
G
A
H
G
Y
S
H
E
N
P
I
A
M
S
-
T
K
Q
E
E
D
V
L
-
L
K
S
V
E
L
I
K
D
L
T
G
K
A
P
----
T
G
Y
V
A
P
W
W
E
F
S
N
I
T
N
E
L
L
-
L
---
K
H
-
G
-
F
K
Y
D
H
S
L
M
H
N
D
F
T
P
Y
Y
V
---
R
V
G
D
S
W
S
K
I
D
Y
S
L
E
A
K
D
W
M
K
P
L
I
R
G
V
E
T
N
L
V
E
I
P
A
N
W
Y
L
D
D
-
L
P
P
M
M
F
I
K
K
S
P
N
S
F
G
F
V
S
P
R
D
I
G
Q
M
W
I
D
Q
F
D
W
V
Y
R
E
-
M
--
D
--
Y
A
--
V
-
F
S
M
T
I
H
P
D
V
S
A
R
P
Q
V
-
L
L
M
H
E
K
I
I
E
H
I
N
K
H
E
G
V
R
W
V
T
F
N
-
E
I
A
D
D
F
L
K
R
N
P
R
--
2
PsiBlast_PDB
97.51
97%
-100
- C6 -
4LY4
1
PGDAE_HELPG
A:
[35-324]
--------------------
A
K
E
I
L
V
A
Y
G
V
D
I
D
A
V
A
--
G
W
L
G
-
S
Y
G
----------------
G
---
E
D
S
P
D
-
D
-
I
S
R
G
L
F
A
G
E
V
G
I
P
R
L
L
K
L
F
K
K
Y
H
L
P
A
T
W
F
V
P
G
-
H
S
I
E
-----
T
-
F
P
E
Q
M
K
M
-
I
V
D
A
G
H
E
V
G
A
H
G
Y
S
H
E
N
P
I
A
M
S
-
T
K
Q
E
E
D
V
L
-
L
K
S
V
E
L
I
K
D
L
T
G
K
A
P
----
T
G
Y
V
A
P
W
W
E
F
S
N
I
T
N
E
L
L
-
L
---
K
H
-
G
-
F
K
Y
D
H
S
L
M
H
N
D
F
T
P
Y
Y
V
---
R
V
G
D
S
W
S
K
I
D
Y
S
L
E
A
K
D
W
M
K
P
L
I
R
G
V
E
T
N
L
V
E
I
P
A
N
W
Y
L
D
D
-
L
P
P
M
M
F
I
K
K
S
P
N
S
F
G
F
V
S
P
R
D
I
G
Q
M
W
I
D
Q
F
D
W
V
Y
R
E
-
M
--
D
--
Y
A
--
V
-
F
S
M
T
I
H
P
D
V
S
A
R
P
Q
V
-
L
L
M
H
E
K
I
I
E
H
I
N
K
H
E
G
V
R
W
V
T
F
N
-
E
I
A
D
D
F
L
K
R
N
P
R
--
1
PsiBlast_PDB
97.40
97%
-101
- C6 -
3QBU
1
PGDAE_HELPG
A:
[35-324]
--------------------
A
K
E
I
L
V
A
Y
G
V
D
I
D
A
V
A
--
G
W
L
G
-
S
Y
G
----------------
G
---
E
D
S
P
D
-
D
-
I
S
R
G
L
F
A
G
E
V
G
I
P
R
L
L
K
L
F
K
K
Y
H
L
P
A
T
W
F
V
P
G
-
H
S
I
E
-----
T
-
F
P
E
Q
M
K
M
-
I
V
D
A
G
H
E
V
G
A
H
G
Y
S
H
E
N
P
I
A
M
S
-
T
K
Q
E
E
D
V
L
-
L
K
S
V
E
L
I
K
D
L
T
G
K
A
P
----
T
G
Y
V
A
P
W
W
E
F
S
N
I
T
N
E
L
L
-
L
---
K
H
-
G
-
F
K
Y
D
H
S
L
M
H
N
D
F
T
P
Y
Y
V
---
R
V
G
D
S
W
S
K
I
D
Y
S
L
E
A
K
D
W
M
K
P
L
I
R
G
V
E
T
N
L
V
E
I
P
A
N
W
Y
L
D
D
-
L
P
P
M
M
F
I
K
K
S
P
N
S
F
G
F
V
S
P
R
D
I
G
Q
M
W
I
D
Q
F
D
W
V
Y
R
E
-
M
--
D
--
Y
A
--
V
-
F
S
M
T
I
H
P
D
V
S
A
R
P
Q
V
-
L
L
M
H
E
K
I
I
E
H
I
N
K
H
E
G
V
R
W
V
T
F
N
-
E
I
A
D
D
F
L
K
R
N
P
R
--
31
HHSearch
72.28
30%
-88
- C6 -
3RXZ
2
?
A:
[22-286]
--------------------
G
K
T
C
A
V
A
F
T
F
D
V
D
A
E
S
--
P
L
L
T
-
T
D
P
A---------------
F
---
A
D
R
M
G
-
T
-
M
S
H
Q
A
Y
G
P
L
V
G
V
P
R
L
L
G
I
L
D
E
F
N
V
P
G
T
F
F
V
P
G
-
Y
T
A
H
-----
R
-
H
P
E
P
I
R
S
-
I
A
R
A
G
H
E
I
A
H
H
G
Y
L
H
E
S
L
V
G
A
D
-
E
D
T
E
R
K
I
L
-
T
R
G
I
E
A
L
E
E
V
A
G
V
H
P
----
V
G
Y
R
A
P
M
W
E
M
N
W
H
T
P
K
L
L
-
A
---
E
F
-
G
-
F
L
Y
D
S
T
L
M
D
S
-
D
H
P
Y
E
L
---
A
V
G
-----------------------
D
G
S
L
V
E
L
P
V
S
W
A
L
D
D
-
W
Q
Q
Y
C
F
V
P
D
F
S
G
T
G
L
I
E
T
P
A
K
A
I
E
L
W
R
A
E
L
N
A
M
R
D
I
-------
G
G
--
A
-
W
V
L
T
N
H
P
F
L
S
G
R
P
G
R
-
A
A
A
L
R
E
F
I
A
E
V
C
A
M
D
D
V
W
V
A
G
M
S
-
Q
I
A
E
H
V
R
A
Q
K
L
T
P
R
3
PsiBlast_PDB
70.49
28%
-84
- C6 -
3RXZ
2
?
A:
[22-278]
--------------------
G
K
T
C
A
V
A
F
T
F
D
V
D
A
E
S
--
P
L
L
T
-
T
D
P
----------------
A
F--
A
D
R
M
G
-
T
-
M
S
H
Q
A
Y
G
P
L
V
G
V
P
R
L
L
G
I
L
D
E
F
N
V
P
G
T
F
F
V
P
G
-
Y
T
A
H
-----
R
-
H
P
E
P
I
R
S
-
I
A
R
A
G
H
E
I
A
H
H
G
Y
L
H
E
S
L
V
G
A
D
-
E
D
T
E
R
K
I
L
-
T
R
G
I
E
A
L
E
E
V
A
G
V
H
P
----
V
G
Y
R
A
P
M
W
E
M
N
W
H
T
P
K
L
L
-
A
---
E
F
-
G
-
F
L
Y
D
S
T
L
M
D
S
D
H
-
P
Y
E
L
---
A
V
G
D
G
-----------------------
S
L
V
E
L
P
V
S
W
A
L
D
D
-
W
Q
Q
Y
C
F
V
P
D
F
S
G
T
G
L
I
E
T
P
A
K
A
I
E
L
W
R
A
E
L
N
-
A
M
R
D
-
I
--
G
--
G
A
----
W
V
L
T
N
H
P
F
L
S
G
R
P
G
R
-
A
A
A
L
R
E
F
I
A
E
V
C
A
M
D
D
V
W
V
A
G
M
S
-
Q
I
A
E
H
V
R
A
Q
K
L
T
P
R
30
HHSearch
67.98
25%
-83
* C6 *
3S6O
-
?
A:
[30-311]
--------------------
R
A
R
V
A
V
Q
F
V
L
N
Y
E
E
G
G
EN
C
V
L
H
-
G
D
P
ASEQFLSEIVG
A
A
A
Y
-
P
---
A
R
H
M
S
-
M
-
E
S
I
Y
E
Y
G
S
R
A
G
V
W
R
I
L
R
E
F
D
K
R
G
L
P
L
T
V
F
G
V
G
-
M
A
I
E
-----
R
-
H
P
E
L
A
R
A
-
F
V
E
L
G
H
E
I
A
C
H
G
W
R
W
I
H
Y
Q
D
M
T
-
P
E
R
E
A
E
H
M
-
R
L
G
M
E
A
I
E
R
V
T
G
V
R
P
----
L
G
W
Y
T
G
R
--
D
S
P
N
T
H
R
L
V
-
A
---
E
Y
G
G
-
F
L
Y
D
S
D
H
Y
G
D
-
D
L
P
F
W
M
---
D
V
E
V
S
G
------------------
G
A
S
V
P
Q
L
I
V
P
Y
T
L
D
A
N
D
-
M
R
F
A
T
P
-------
Q
G
F
N
T
A
D
H
F
F
H
Y
L
R
D
A
F
D
V
L
Y
E
E
-
G
--
D
E
A
P
K
--
M
-
M
S
I
G
M
H
C
R
L
L
G
R
P
G
R
-
F
R
A
L
Q
R
F
L
D
H
I
E
R
H
D
R
V
W
V
A
R
R
V
-
E
I
A
R
H
W
R
E
H
H
P
Y
--
29
HHSearch
66.30
25%
-87
- C6 -
3CL6
-
?
A:
[23-303]
-------------------
G
K
A
R
I
A
L
S
F
V
L
N
Y
E
E
G
G
ER
N
I
L
H
G
D
K
E
S
E
A
F
LSEMVSAQ----
P
LQG
E
R
N
M
S
-
M
-
E
S
L
Y
E
Y
G
S
R
A
G
V
W
R
I
L
K
L
F
K
A
F
D
I
P
L
T
I
F
A
V
A
-
M
A
A
Q
-----
R
-
H
P
D
V
I
R
A
-
M
V
A
A
G
H
E
I
C
S
H
G
Y
R
W
I
D
Y
Q
Y
M
D
-
E
A
Q
E
R
E
H
M
-
L
E
A
I
R
I
L
T
E
L
T
G
E
R
P
----
L
G
W
Y
T
G
R
T
--
G
P
N
T
R
R
L
V
M
E
---
E
G
-
G
-
F
L
Y
D
C
D
T
Y
D
D
-
D
L
P
Y
W
E
---
P
N
N
---------------------
P
T
G
K
P
H
L
V
I
P
Y
T
L
D
T
N
D
-
M
R
F
T
Q
V
Q
-------
G
F
N
K
G
D
D
F
F
E
Y
L
K
D
A
F
D
V
L
Y
A
E
-
G
AE
A
--
P
K
--
M
-
L
S
I
G
L
H
C
R
L
I
G
R
P
A
R
-
L
A
A
L
Q
R
F
I
E
Y
A
K
S
H
E
Q
V
W
F
T
R
R
V
-
D
I
A
R
H
W
H
A
T
H
P
Y
T
-
49
Fugue
63.40
24%
-80
- C6 -
1Z7A
3
?
A:
[4-304]
DYPRDLIGYGNNPPHPHWP
G
D
A
R
I
A
L
S
F
V
L
N
Y
E
E
G
G
--
E
R
C
V
-
L
H
G
DK
E
S
E
A
F
LSEMVAAQP
L
---
Q
G
V
R
H
M
S
M
E
S
L
Y
E
Y
G
S
R
A
G
V
W
R
L
L
K
L
F
K
R
R
N
V
P
L
T
V
F
A
V
A
M
A
-
A
Q
-----
R
-
N
P
E
V
I
R
A
M
V
A
D
-
G
H
E
I
C
S
H
G
Y
R
W
I
D
--
Y
Q
Y
M
D
E
A
Q
E
R
E
H
M
L
E
A
I
R
I
L
T
E
L
T
G
Q
R
P
----
V
G
W
Y
T
G
R
T
--
G
P
N
T
R
R
L
V
M
E
---
E
G
-
G
-
F
L
Y
D
S
D
T
Y
D
D
D
-
L
P
Y
W
D
---
P
A
S
T
A
---------------------
E
K
P
H
L
V
I
P
Y
T
L
D
T
N
D
M
R
F
T
Q
--------
V
Q
G
F
N
N
G
E
Q
F
F
Q
Y
L
K
D
A
F
D
V
L
Y
E
E
G
A
--
T
--
A
P
--
K
M
L
S
I
G
L
H
C
R
L
I
G
R
P
A
R
M
A
A
L
-
E
R
F
I
Q
Y
A
Q
S
H
D
K
V
W
F
A
R
R
E
-
D
I
A
R
H
W
H
R
E
H
P
F
Q
-
8
PsiBlast_PDB
62.65
26%
-76
- C6 -
3S6O
-
?
A:
[82-311]
-------------------------------------------------------------------------------
Y
G
S
R
A
G
V
W
R
I
L
R
E
F
D
K
R
G
L
P
L
T
V
F
G
V
G
-
M
A
I
E
-----
R
-
H
P
E
L
A
R
A
-
F
V
E
L
G
H
E
I
A
C
H
G
W
R
W
I
H
Y
Q
D
M
T
-
P
E
R
E
A
E
H
M
-
R
L
G
M
E
A
I
E
R
V
T
G
V
R
P
----
L
G
W
Y
T
G
--
R
D
S
P
N
T
H
R
L
V
-
A
---
E
Y
-
G
G
F
L
Y
D
-
S
D
H
Y
G
D
D
L
P
F
----------
W
M
D
V
E
V
S
-----------
G
G
A
S
V
P
Q
L
I
V
P
---
Y
T
L
D
-
A
N
D
M
R
F
A
T
P
Q
----
G
F
N
T
A
D
H
F
F
H
Y
L
R
D
A
F
D
V
L
Y
E
E
-
G
--
D
--
E
A
P
K
M
-
M
S
I
G
M
H
C
R
L
L
G
R
P
G
R
-
F
R
A
L
Q
R
F
L
D
H
I
E
R
H
D
R
V
-
W
V
A
R
R
V
E
I
A
R
H
W
R
E
H
H
P
Y
--
7
PsiBlast_PDB
61.08
26%
-80
- C6 -
1Z7A
3
?
A:
[77-302]
-------------------------------------------------------------------------------
Y
G
S
R
A
G
V
W
R
L
L
K
L
F
K
R
R
N
V
P
L
T
V
F
A
V
A
-
M
A
A
Q
-----
R
-
N
P
E
V
I
R
A
-
M
V
A
D
G
H
E
I
C
S
H
G
Y
R
W
I
D
Y
Q
Y
M
D
-
E
A
Q
E
R
E
H
M
-
L
E
A
I
R
I
L
T
E
L
T
G
Q
R
P
----
V
G
----
W
Y
T
G
R
T
G
P
N
T
R
R
-
L
V
M
E
E
G
-
G
-
F
L
Y
D
-
S
D
T
Y
D
D
D
L
P
Y
W
-----------------------
D
P
A
S
T
A
E
K
P
H
L
V
-
I
P
---
Y
T
L
D
-
T
N
D
M
R
F
T
Q
V
Q
----
G
F
N
N
G
E
Q
F
F
Q
Y
L
K
D
A
F
D
V
L
Y
E
E
-
G
--
A
--
T
A
P
K
M
-
L
S
I
G
L
H
C
R
L
I
G
R
P
A
R
-
M
A
A
L
E
R
F
I
Q
Y
A
Q
S
H
D
K
V
W
F
A
R
R
E
-
D
I
A
R
H
W
H
R
E
H
P
F
Q
-
41
HHSearch
55.37
18%
-72
- C6 -
2C1I
3
PGDA_STRR6
A:
[236-421]
--------------------------------------------------------------------
K
V
V
-
A
-
L
T
F
N
D
G
P
N
P
A
T
T
P
Q
V
L
E
T
L
A
K
Y
D
I
K
A
T
F
F
V
L
G
-
K
N
V
S
-----
G
-
N
E
D
L
V
K
R
-
I
K
S
E
G
H
V
V
G
N
H
S
W
S
H
P
I
L
S
Q
L
S
-
L
D
E
A
K
K
Q
I
-
T
D
T
E
D
V
L
T
K
V
L
G
S
S
S
----
K
L
M
R
P
P
Y
G
A
I
T
D
D
I
R
N
-------
S
L
-
D
-
L
S
F
-------------------------
I
M
W
D
V
D
S
L
D
W
K
S
K
--------------------------------------
N
E
A
S
I
L
T
E
I
Q
---
H
Q
V
-
A
--------
N
G
----
S
I
V
L
M
H
D
I
H
---
S
P
T
-
V
N
A
L
P
R
V
I
E
Y
L
K
N
-
Q
G
Y
T
F
V
T
I
P
-
E
M
L
N
T
R
L
K
A
H
E
L
Y
Y
5
PsiBlast_PDB
54.20
26%
-78
- C6 -
3CL7
1
?
A:
[77-288]
-------------------------------------------------------------------------------
Y
G
S
R
A
G
V
W
R
I
L
K
L
F
K
A
F
D
I
P
L
T
I
F
A
V
A
-
M
A
A
Q
-----
R
-
H
P
D
V
I
R
A
-
M
V
A
A
G
H
E
I
C
S
H
G
Y
R
W
I
D
Y
Q
Y
M
D
-
E
A
Q
E
R
E
H
M
-
L
E
A
I
R
I
L
T
E
L
T
G
E
R
P
LGWY
T
G
R
T
G
P
-----
N
T
R
R
L
V
M
-
E
---
E
G
-
G
-
F
L
Y
D
C
D
T
Y
D
D
D
L
-
P
Y
W
E
PNN
P
T
G
K
P
H
L
V
I
P
Y
T
L
D
T
N
D
----------------------------
M
R
F
T
Q
V
Q
----
G
F
N
K
G
D
D
F
F
E
Y
L
K
D
A
F
D
V
L
Y
A
E
-
G
--
A
--
E
A
P
K
M
-
L
S
I
G
L
H
C
R
L
I
G
R
P
A
R
-
L
A
A
L
Q
R
F
I
E
Y
A
K
S
H
E
Q
V
-
W
F
T
R
R
-
V
D
I
A
R
H
W
H
A
T
H
P
Y
T
6
PsiBlast_PDB
53.75
26%
-81
- C6 -
3CL8
1
?
A:
[77-288]
-------------------------------------------------------------------------------
Y
G
S
R
A
G
V
W
R
I
L
K
L
F
K
A
F
D
I
P
L
T
I
F
A
V
A
-
M
A
A
Q
-----
R
-
H
P
D
V
I
R
A
-
M
V
A
A
G
H
E
I
C
S
H
G
Y
R
W
I
D
Y
Q
Y
M
D
-
E
A
Q
E
R
E
H
M
-
L
E
A
I
R
I
L
T
E
L
T
G
E
R
P
LGWY
T
G
R
T
G
P
-----
N
T
R
R
L
V
M
-
E
---
E
G
-
G
-
F
L
Y
D
C
D
T
Y
D
D
D
L
-
P
Y
W
E
PNN
P
T
G
K
P
H
L
V
I
P
Y
T
L
D
T
N
D
----------------------------
M
R
F
T
Q
V
Q
----
G
F
N
K
G
D
D
F
F
E
Y
L
K
D
A
F
D
V
L
Y
A
E
-
G
--
A
--
E
A
P
K
M
-
L
S
I
G
L
H
C
R
L
I
G
R
P
A
R
-
L
A
A
L
Q
R
F
I
E
Y
A
K
S
H
E
Q
V
-
W
F
T
R
R
-
V
D
I
A
R
H
W
H
A
T
H
P
Y
T
42
HHSearch
53.30
21%
-68
- C6 -
2C71
1
?
A:
[19-193]
------------------------------------------------------------------------------------
L
T
A
R
V
L
D
K
L
D
K
Y
N
V
K
A
T
F
M
V
V
G
-
Q
R
V
N
-----
D
S
T
A
A
I
I
R
R
-
M
V
N
S
G
H
E
I
G
N
H
S
W
S
Y
S
G
M
A
N
M
S
-
P
D
Q
I
R
K
S
I
-
A
D
T
N
A
V
I
Q
K
Y
A
G
T
T
P
----
K
F
F
R
P
P
N
L
E
T
S
P
T
L
F
N
N
V
--------
D
-
L
V
F
V
G
--------------------------
G
L
T
A
N
D
W
I
P
S
-------
T
------------------------------
T
A
E
Q
R
A
A
A
V
I
---
N
G
V
-
R
--------
D
G
--
T
--
I
I
L
L
H
D
V
Q
P
E
P
H
P
T
-
P
E
A
L
D
I
I
I
P
T
L
K
S
-
R
G
Y
E
F
V
T
L
T
-
E
L
F
T
L
K
G
V
P
I
D
P
S
V
34
HHSearch
53.05
20%
-54
- C6 -
2IW0
6
?
A:
[43-245]
---------------------------------------------------------------------
L
V
-
A
-
L
T
Y
D
D
-
G
P
F
T
F
T
P
Q
L
L
D
I
L
K
Q
N
D
V
R
A
T
F
F
V
N
G
-
N
N
W
A
NIEAG
S
-
N
P
D
T
I
R
R
-
M
R
A
D
G
H
L
V
G
S
H
T
Y
A
H
P
D
L
N
T
L
S
-
S
A
D
R
I
S
Q
M
-
R
Q
L
E
E
A
T
R
R
I
D
G
F
A
P
----
K
Y
M
R
A
P
Y
L
S
C
D
A
G
C
Q
G
D
L
-
G
---
G
L
-
G
-
Y
H
I
-------------------------
I
D
T
N
L
D
T
K
D
Y
E
N
N
K
P
-----
E
T
T
H
--------------------------
L
S
A
E
K
F
----
N
N
E
L
S
A
D
V
------
G
--
A
N
--
S
-
Y
I
V
L
S
H
D
V
H
E
Q
--
T
V
-
V
S
L
T
Q
K
L
I
D
T
L
K
S
-
K
G
Y
R
A
V
T
V
G
-
E
C
L
G
D
A
P
E
N
W
Y
K
A
H