@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0620: (2015-12-16 )
MLFAMIGSGGFIAPKHLQAIRDTGHFLDCSFDVHDSVGVLDEYFPQSEFFTNIEDFEKHLEQSKAMGKEINYLSVCTPTHTHFDHIRFGLRNGMHVICEKPLVLDPSEIQELKDLEVKYQKRVFSLLPLRLHCDTLALKEKIKSELDKNPEKVFDITLTYISVQGKWYFSSWRADVNRSGGLATQMGVNIFDTLLYLFGGVKDKVINREEPDCVCGILFLEHAKIRWFFSINPEHMGVAKEKVYHKMILEGEEVNLTQSFDNLYIESYKQILAQGGFGLDDAAASIKLAYELRNLSLSEPNDDSHALCCKNKTDQ
Atome Classification :
(20 SA)
-.......-..10...-.-....20.--.--......30......-..40------........50...---.....60......---.-.70........80........90........100.......110.......-120.......130.......140....-...150.......160...---.-...170.....-..180.......190.......200..-....-------.-----------.210.......220---...-..-..230----.....---.--.-240-.........-----------------------------------250------------.---------------------.-------------------------.---------.-.....260.......270....--.---..280.......290.......300........310...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
L
F
A
M
IG-SGGFI
A
P
-
K
-
H
L
Q
A
I
R
D--T--G
H
F
L
D
C
S
F
DVHDSV-
G
V
L
D
------
E
YF
P
Q
S
E
FFT
N
I
E
---
D
F
E
K
H
L
E
Q
S
K
AMG---K-EI
N
Y
L
S
VCTPTHT
H
F
D
H
I
R
F
G
L
RNG
M
H
V
ICEKPLVL
D
P
S
E
I
Q
E
L
K
D
L
E
V
K
Y
-
Q
K
R
V
F
S
LLP
L
R
LHC
D
T
L
A
L
K
E
K
I
K
S
E
L
-DKNP
E
K
V
F
D
I
T
L
T
Y
I
S
V
Q
G
---
K
-
W
Y
F
SSWRADVN-RSGG
L
A
T
Q
M
G
V
N
I
F
D
T
L
L
Y
L
FGG-VKD-KVIN-------R-----------EEP
D
C
V
C
G
I
L
F
LEH---A
K
I
-
R
W
-
F
F
S
I
N
----
P
E
HM
G
---
V
--
A
-
K
---
E
K
V
Y
H
K
M
IL-----------------------------------E--------------G---------------------E-------------------------E---------V-N
L
T
Q
S
F
D
N
L
Y
I
E
S
Y
K
Q
I
L
A
QGG--F---GLDD
A
A
A
S
I
K
L
A
Y
E
LRNLSLSEP-NDDS
H
A
L
CCKNKTDQ
1
PsiBlast_PDB
93.43
42%
-106
- C1 -
3O9Z
7
?
A:
[6-307]
---
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
--
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
D
------
S
F
F
P
E
A
E
F
F
T
E
P
E
---
A
F
E
A
Y
L
E
D
L
R
D
R
G
---
E
-
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
-
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
-----
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-----------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
-
F
L
S
I
D
PSFV
P
E
P
L
R
---
R
--
Q
-
G
---
K
R
T
Y
R
S
I
A
V
-----------------------------------
D
--------------
G
---------------------
E
-------------------------
E
---------
V
-
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
--
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
-
S
P
E
N
R
H
P
F
L
G
-----
2
PsiBlast_PDB
93.01
42%
-109
* C1 *
3OA0
7
?
A:
[6-307]
---
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
--
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
D
------
S
F
F
P
E
A
E
F
F
T
E
P
E
---
A
F
E
A
Y
L
E
D
L
R
D
R
G
---
E
-
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
-
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
-----
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-----------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
-
F
L
S
I
D
PSFV
P
E
P
L
R
---
R
--
Q
-
G
---
K
R
T
Y
R
S
I
A
V
-----------------------------------
D
--------------
G
---------------------
E
-------------------------
E
---------
V
-
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
--
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
-
S
P
E
N
R
H
P
F
L
G
-----
24
PsiBlast_CBE
93.00
42%
-104
- C1 -
3O9Z
7
?
D:
[6-307]
---
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
--
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
D
------
S
F
F
P
E
A
E
F
F
T
E
P
E
---
A
F
E
A
Y
L
E
D
L
R
D
R
G
---
E
-
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
-
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
-----
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-----------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
-
F
L
S
I
D
PSFV
P
E
P
L
R
---
R
--
Q
-
G
---
K
R
T
Y
R
S
I
A
V
-----------------------------------
D
--------------
G
---------------------
E
-------------------------
E
---------
V
-
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
--
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
-
S
P
E
N
R
H
P
F
L
------
21
PsiBlast_CBE
92.91
42%
-107
- C1 -
3OA0
7
?
D:
[6-307]
---
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
--
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
D
------
S
F
F
P
E
A
E
F
F
T
E
P
E
---
A
F
E
A
Y
L
E
D
L
R
D
R
G
---
E
-
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
-
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
-----
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-----------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
-
F
L
S
I
D
PSFV
P
E
P
L
R
---
R
--
Q
-
G
---
K
R
T
Y
R
S
I
A
V
-----------------------------------
D
--------------
G
---------------------
E
-------------------------
E
---------
V
-
E
F
S
E
G
--
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
--
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
-
S
P
E
N
R
H
P
F
L
------
25
PsiBlast_CBE
92.71
42%
-107
- C1 -
3O9Z
8
?
C:
[6-307]
---
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
--
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
D
------
S
F
F
P
E
A
E
F
F
T
E
P
E
---
A
F
E
A
Y
L
E
D
L
R
D
R
G
---
E
-
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
-
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
-----
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-----------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
-
F
L
S
I
D
PSFV
P
E
P
L
R
---
R
--
Q
-
G
---
K
R
T
Y
R
S
I
A
V
-----------------------------------
D
--------------
G
---------------------
E
-------------------------
E
---------
V
-
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
--
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
-
S
P
E
N
R
H
P
F
L
G
-----
22
PsiBlast_CBE
92.71
42%
-106
- C1 -
3OA0
7
?
C:
[6-307]
---
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
--
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
D
------
S
F
F
P
E
A
E
F
F
T
E
P
E
---
A
F
E
A
Y
L
E
D
L
R
D
R
G
---
E
-
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
-
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
-----
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-----------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
-
F
L
S
I
D
PSFV
P
E
P
L
R
---
R
--
Q
-
G
---
K
R
T
Y
R
S
I
A
V
-----------------------------------
D
--------------
G
---------------------
E
-------------------------
E
---------
V
-
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
--
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
-
S
P
E
N
R
H
P
F
L
G
-----
23
PsiBlast_CBE
92.65
42%
-103
- C1 -
3OA0
7
?
B:
[6-307]
---
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
--
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
D
------
S
F
F
P
E
A
E
F
F
T
E
P
E
---
A
F
E
A
Y
L
E
D
L
R
D
R
G
---
E
-
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
-
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
-----
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-----------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
-
F
L
S
I
D
PSFV
P
E
P
L
R
---
R
--
Q
-
G
---
K
R
T
Y
R
S
I
A
V
-----------------------------------
D
--------------
G
---------------------
E
-------------------------
E
---------
V
-
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
--
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
-
S
P
E
N
R
H
P
F
L
G
-----
26
PsiBlast_CBE
91.92
42%
-106
- C1 -
3O9Z
9
?
B:
[6-307]
---
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
--
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
D
------
S
F
F
P
E
A
E
F
F
T
E
P
E
---
A
F
E
A
Y
L
E
D
L
R
D
R
G
---
E
-
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
-
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
-
G
A
K
-----
D
V
V
L
T
Y
V
T
G
R
G
---
K
-
W
Y
G
K
S
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-----------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
-
F
L
S
I
D
PSFV
P
E
P
L
R
---
R
--
Q
-
G
---
K
R
T
Y
R
S
I
A
V
-----------------------------------
D
--------------
G
---------------------
E
-------------------------
E
---------
V
-
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
--
F
---
G
L
D
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
-
S
P
E
N
R
H
P
F
L
G
-----
51
HHSearch
90.35
37%
-111
- C1 -
3OA2
3
WBPB_PSEAE
A:
[4-311]
-
K
N
F
A
L
I
G
A
A
-
G
Y
I
A
P
-
R
-
H
M
R
A
I
K
D
--
T
--
G
N
C
L
V
S
A
Y
D
I
N
D
S
V
-
G
I
I
D
------
S
I
S
P
Q
S
E
F
F
T
E
F
E
---
F
F
L
D
H
A
S
N
L
K
--
R
DSA
T
-
A
L
D
Y
V
S
I
C
S
P
N
Y
L
H
Y
P
H
I
A
A
G
L
R
L
G
C
D
V
I
C
E
K
P
L
V
P
T
P
E
M
L
D
Q
L
A
V
I
E
R
E
T
-
D
K
R
L
Y
N
I
L
Q
L
R
H
H
Q
A
I
I
A
L
K
D
K
V
A
R
E
--
S
---
P
H
K
Y
E
V
D
L
T
Y
I
T
S
R
G
---
N
-
W
Y
L
K
S
W
K
G
D
P
R
-
K
S
F
G
V
A
T
N
I
G
V
H
F
Y
D
M
L
H
F
I
F
G
K
-
L
Q
R
N
V
V
H
--------
F
-----------
T
S
E
Y
K
T
A
G
Y
L
E
Y
E
Q
---
A
R
V
-
R
W
F
L
S
V
D
A
----
N
D
-
L
P
---
E
--
S
-
V
KGK
K
P
T
Y
R
S
I
T
V
-----------------------------------
N
--------------
G
---------------------
E
-------------------------
E
---------
M
-
E
F
-----
D
L
H
T
T
S
Y
E
E
I
L
A
G
R
G
--
Y
---
G
I
D
D
A
R
H
C
V
E
T
V
N
T
I
R
S
A
V
I
V
P
A
S
D
N
E
G
H
P
F
V
A
------
27
PsiBlast_CBE
89.62
38%
-110
- C1 -
3OA2
3
WBPB_PSEAE
C:
[6-307]
---
F
A
L
I
G
-
A
A
G
Y
I
A
P
-
R
-
H
M
R
A
I
K
D
--
T
--
G
N
C
L
V
S
A
Y
D
I
N
D
S
V
-
G
I
I
D
------
S
I
S
P
Q
S
E
F
F
T
E
F
E
F
F
L
D
H
A
S
N
L
K
R
D
S
A
T
A
------
L
D
Y
V
S
I
C
S
P
N
Y
L
H
Y
P
H
I
A
A
G
L
R
L
G
C
D
V
I
C
E
K
P
L
V
P
T
P
E
M
L
D
Q
L
A
V
I
E
R
E
T
-
D
K
R
L
Y
N
I
L
Q
L
R
H
H
Q
A
I
I
A
L
K
D
K
V
A
R
E
---
K
S
P
H
K
-
Y
E
V
D
L
T
Y
I
T
S
R
G
---
N
-
W
Y
L
K
S
W
K
G
D
P
R
-
K
S
F
G
V
A
T
N
I
G
V
H
F
Y
D
M
L
H
F
I
F
G
K
-
L
Q
R
-
N
V
V
H
-------
F
-----------
T
S
E
Y
K
T
A
G
Y
L
E
Y
E
Q
---
A
R
V
-
R
W
-
F
L
S
V
D
ANDL
P
-----------------
P
T
Y
R
S
I
T
V
-----------------------------------
N
--------------
G
---------------------
E
-------------------------
E
---------
M
-
E
F
-----
D
L
H
T
T
S
Y
E
E
I
L
A
G
R
G
--
Y
---
G
I
D
D
A
R
H
C
V
E
T
V
N
T
I
R
S
A
V
I
V
P
A
-
S
D
N
E
G
H
P
F
V
------
28
PsiBlast_CBE
89.36
38%
-111
- C1 -
3OA2
3
WBPB_PSEAE
B:
[6-307]
---
F
A
L
I
G
-
A
A
G
Y
I
A
P
-
R
-
H
M
R
A
I
K
D
--
T
--
G
N
C
L
V
S
A
Y
D
I
N
D
S
V
-
G
I
I
D
------
S
I
S
P
Q
S
E
F
F
T
E
F
E
F
F
L
D
H
A
S
N
L
K
R
D
S
A
T
A
------
L
D
Y
V
S
I
C
S
P
N
Y
L
H
Y
P
H
I
A
A
G
L
R
L
G
C
D
V
I
C
E
K
P
L
V
P
T
P
E
M
L
D
Q
L
A
V
I
E
R
E
T
-
D
K
R
L
Y
N
I
L
Q
L
R
H
H
Q
A
I
I
A
L
K
D
K
V
A
R
E
---
K
S
P
H
K
-
Y
E
V
D
L
T
Y
I
T
S
R
G
---
N
-
W
Y
L
K
S
W
K
G
D
P
R
-
K
S
F
G
V
A
T
N
I
G
V
H
F
Y
D
M
L
H
F
I
F
G
K
-
L
Q
R
-
N
V
V
H
-------
F
-----------
T
S
E
Y
K
T
A
G
Y
L
E
Y
E
Q
---
A
R
V
-
R
W
-
F
L
S
V
D
ANDL
P
E
S
V
K
------
G
-
K
---
K
P
T
Y
R
S
I
T
V
-----------------------------------
N
--------------
G
---------------------
E
-------------------------
E
---------
M
-
E
F
-----
D
L
H
T
T
S
Y
E
E
I
L
A
G
R
G
--
Y
---
G
I
D
D
A
R
H
C
V
E
T
V
N
T
I
R
S
A
V
I
V
P
A
-
S
D
N
E
G
H
P
F
V
A
A
L
A
R
-
3
PsiBlast_PDB
88.84
38%
-109
- C1 -
3OA2
3
WBPB_PSEAE
A:
[6-307]
---
F
A
L
I
G
-
A
A
G
Y
I
A
P
-
R
-
H
M
R
A
I
K
D
--
T
--
G
N
C
L
V
S
A
Y
D
I
N
D
S
V
-
G
I
I
D
------
S
I
S
P
Q
S
E
F
F
T
E
F
E
F
F
L
D
H
A
S
N
L
K
R
D
S
A
T
A
------
L
D
Y
V
S
I
C
S
P
N
Y
L
H
Y
P
H
I
A
A
G
L
R
L
G
C
D
V
I
C
E
K
P
L
V
P
T
P
E
M
L
D
Q
L
A
V
I
E
R
E
T
-
D
K
R
L
Y
N
I
L
Q
L
R
H
H
Q
A
I
I
A
L
K
D
K
V
A
R
E
----
S
P
H
K
-
Y
E
V
D
L
T
Y
I
T
S
R
G
---
N
-
W
Y
L
K
S
W
K
G
D
P
R
-
K
S
F
G
V
A
T
N
I
G
V
H
F
Y
D
M
L
H
F
I
F
G
K
-
L
Q
R
-
N
V
V
H
-------
F
-----------
T
S
E
Y
K
T
A
G
Y
L
E
Y
E
Q
---
A
R
V
-
R
W
-
F
L
S
V
D
ANDL
P
E
S
V
K
------
G
-
K
---
K
P
T
Y
R
S
I
T
V
-----------------------------------
N
--------------
G
---------------------
E
-------------------------
E
---------
M
-
E
F
-----
D
L
H
T
T
S
Y
E
E
I
L
A
G
R
G
--
Y
---
G
I
D
D
A
R
H
C
V
E
T
V
N
T
I
R
S
A
V
I
V
P
A
-
S
D
N
E
G
H
P
F
V
A
-----
70
Fugue
87.28
35%
-102
- C1 -
3OA2
3
WBPB_PSEAE
A:
[3-314]
M
K
N
F
A
L
I
G
-
A
A
G
Y
I
A
P
-
R
-
H
M
R
A
I
K
D
--
T
--
G
N
C
L
V
S
A
Y
D
I
N
D
S
V
-
G
I
I
D
------
S
I
S
P
Q
S
E
F
F
T
E
F
E
---
F
F
L
D
H
A
S
N
L
K
R
D
S
---
A
T
A
L
D
Y
V
S
I
C
S
P
N
Y
L
H
Y
P
H
I
A
A
G
L
R
L
G
C
D
V
I
C
E
K
P
L
V
P
T
P
E
M
L
D
Q
L
A
V
I
E
R
E
T
-
D
K
R
L
Y
N
I
L
Q
L
R
H
H
Q
A
I
I
A
L
K
D
K
V
A
R
-----
E
S
P
H
K
Y
E
V
D
L
T
Y
I
T
S
R
G
---
N
-
W
Y
L
K
S
W
K
G
D
P
R
-
K
S
F
G
V
A
T
N
I
G
V
H
F
Y
D
M
L
H
F
I
F
G
K
-
L
Q
R
-
N
V
V
H
-------
F
-----------
T
S
E
Y
K
T
A
G
Y
L
E
Y
E
Q
---
A
R
V
-
R
W
-
F
L
S
V
D
----
A
N
D
L
P
--------
E
---
S
V
K
G
K
K
P
T
Y
-----------------------------------
R
--------------
S
---------------------
I
-------------------------
T
---------
V
-
N
G
E
E
M
E
F
D
L
H
T
T
S
Y
E
E
I
L
A
G
R
G
--
Y
---
G
I
D
D
A
R
H
C
V
E
T
V
N
T
I
R
S
A
V
I
V
P
A
-
S
D
N
E
G
H
P
F
V
A
-----
52
HHSearch
84.28
38%
-97
- C1 -
3O9Z
7
?
A:
[4-306]
-
T
R
F
A
L
T
G
-
L
A
G
Y
I
A
P
-
R
-
H
L
K
A
I
K
E
--
V
--
G
G
V
L
V
A
S
L
D
P
A
T
N
V
-
G
L
V
D
SFFPE
A
E
F
F
T
E
P
E
A
F
E
A
Y
L
---
E
D
L
R
--------
D
R
G-
E
-
G
V
D
Y
L
S
I
A
S
P
N
H
L
H
Y
P
Q
I
R
M
A
L
R
L
G
A
N
A
L
S
E
K
P
L
V
L
W
P
E
E
I
A
R
L
K
E
L
E
A
R
T
-
G
R
R
V
Y
T
V
L
Q
L
R
V
H
P
S
L
L
A
L
K
E
R
L
G
Q
E
K
G
A
---
K
D
V
V
L
T
Y
V
T
G
R
---
G
---
K
-
W
Y
G
K
S
W
K
V
D
E
A
-
K
S
G
G
L
A
T
N
I
G
I
H
F
F
D
L
L
A
W
L
F
G
R
-
A
L
H
-
V
E
V
H
-------
A
-----------
R
T
P
T
V
N
A
G
Y
L
E
L
E
G
---
A
R
V
-
R
W
-
F
L
S
I
D
----
P
S
F
V
P
---
E
--
P
L
R
R
Q
G
K
R
T
Y
R
S
I
A
V
-----------------------------------
D
--------------
G
---------------------
E
-------------------------
E
---------
V
-
E
F
S
E
G
F
T
D
L
H
T
E
V
Y
R
K
T
L
A
G
E
G
--
F
GLD
E
A
A
E
A
I
R
V
A
A
L
L
R
T
L
P
L
S
Q
P
S
P
E
-
N
R
H
P
F
L
G
--------
65
HHSearch
63.73
18%
-91
- C1 -
3GDO
-
IOLW_BACSU
A:
[14-356]
-
I
K
V
G
I
L
G
-
Y
G
-
L
S
G
S
-
V
F
H
G
P
L
L
D
V
--
L
D-
E
Y
Q
I
S
K
I
M
T
S
R
T
E
E
---
V
K
------
R
D
F
P
D
A
E
V
V
H
E
L
E
---
E
I
T
N
--------
D
---
P
-
A
I
E
L
V
I
V
T
T
P
S
G
L
H
Y
E
H
T
M
A
C
I
Q
A
G
K
H
V
V
M
E
K
P
M
T
A
T
A
E
E
G
E
T
L
K
R
A
A
D
E
K
-
G
V
L
L
S
V
Y
H
N
R
R
W
D
N
D
F
L
T
I
K
K
L
I
S
E
G
S
-
L
---
E
D
I
N
T
Y
Q
V
S
Y
N
R
Y
R
P
-----
E
V
-----------
A
T
G
T
L
Y
D
L
G
S
H
I
I
D
Q
T
L
H
L
F
G
M
-
P
K
A
-
V
T
A
N
V
M
A
QREN
A
-----------
E
T
V
D
Y
F
H
L
T
L
D
Y
G
K
---
L
Q
A
-
I
L
-
Y
G
G
S
I
----
V
P
A
N
G
---
P
R
Y
Q
-
I
---
H
G
K
D
S
S
F
I
K
Y
G
I
DG
Q
E
D
A
L
R
A
GRKPEDDSWGADVPEF
Y
G
K
L
T
T
I
R
--------------
G
---------------------
S
D
K
-----------------------
K
T
E
T
------
I
P
S
V
N
G
S
Y
L
T
Y
Y
R
K
I
A
E
S
I
R
E
G
A
A
--
L
PV-
T
A
E
E
G
I
N
V
I
R
I
I
E
A
A
M
E
S
S
K
E
K
R
-
T
I
M
L
E
----------
50
HHSearch
62.18
18%
-81
- C1 -
3KUX
1
?
A:
[8-348]
-
I
K
V
G
L
L
G
-
Y
G
-
Y
A
S
K
-
T
F
H
A
P
L
I
M
G
--
T
P-
G
L
E
L
A
G
V
S
S
S
D
A
S
K
-
V
H
-
A
------
D
-
W
P
A
I
P
V
V
S
D
P
Q
---
M
L
F
N
--------
D
---
P
-
S
I
D
L
I
V
I
P
T
P
N
D
T
H
F
P
L
A
Q
S
A
L
A
A
G
K
H
V
V
V
D
K
P
F
T
V
T
L
S
Q
A
N
A
L
K
E
H
A
D
D
A
-
G
L
L
L
S
V
F
H
N
R
R
W
D
S
D
F
L
T
L
K
T
L
L
A
E
G
S
-
L
---
G
N
V
V
Y
F
E
S
H
F
D
R
Y
R
P
---
E
--
I
R
Q
R
W
R
E
Q
----
G
G
G
I
W
Y
D
L
G
P
H
L
L
D
Q
A
L
Q
L
F
G
L
-
P
E
T
-
L
N
V
D
L
G
M
LRPG
S
-----------
Q
S
V
D
Y
F
H
A
V
L
S
Y
P
G
---
Q
R
V
-
V
L
-
H
S
T
V
L
----
A
A
A
E
T
---
A
R
Y
I
-
V
---
H
G
T
Q
G
S
Y
I
K
-----------------------------------
F
G
V
DP
Q
E
D
R
L
K
A
---
G
---------------------
E
RLPQADWGYDMR
D
G
I
V
T
L
S
H
DN
V
L
T
E
K
P
L
------
L
-
T
L
P
G
N
Y
P
A
Y
Y
A
G
I
R
D
A
I
W
G
T
A
P
--
N
PV-
P
A
T
E
A
I
K
V
M
E
L
I
E
L
G
I
A
S
D
Q
Q
K
K
-
A
L
P
I
I
A
K
N
-------
48
HHSearch
61.06
16%
-76
- C1 -
1ZH8
7
?
A:
[19-337]
-
I
R
L
G
I
V
G
-
C
G
-
I
A
A
R
E
L
-
H
L
P
A
L
K
N
--
L
SH
L
F
E
I
T
A
V
T
S
R
T
R
S
H
A
E
E
F
A
------
K
M
V
G
N
P
A
V
F
D
S
Y
E
---
E
L
L
E
--------
S
---
G
-
L
V
D
A
V
D
L
T
L
P
V
E
L
N
L
P
F
I
E
K
A
L
R
K
G
V
H
V
I
C
E
K
P
I
S
T
D
V
E
T
G
K
K
V
V
E
L
S
E
K
S
-
E
K
T
V
Y
I
A
E
N
F
R
H
V
P
A
F
W
K
A
K
E
L
V
E
S
G
A
-
I
---
G
D
P
V
F
M
N
W
Q
I
W
V
G
M
D
ENN
K
-
Y
V
H
T
D
W
R
K
K
P
K
-
H
V
G
G
F
L
S
D
G
G
V
H
H
A
A
A
M
R
L
I
L
G
E
-
I
E
W
-
I
S
A
V
A
K
D
LSPL
L
-----------
G
G
M
D
F
L
S
S
I
F
E
F
E
N
---
G
T
V
G
N
Y
-
T
I
S
Y
S
----
L
K
G
N
E
---
R
F
-
E
-
I
---
T
G
T
K
G
K
I
S
I
-----------------------------------
S
--------------
W
---------------------
D
K
I
V
L
NE
E
E
M
----------------
K
---------
V
-
P
Q
E
N
S
Y
Q
K
E
F
E
D
F
Y
Q
V
V
A
E
G
K
P
ND
L
G--
S
P
V
Q
A
L
K
D
L
A
F
I
E
A
C
V
R
S
A
G
N
K
V
-
F
V
S
S
L
L
---------
53
HHSearch
60.06
16%
-85
- C1 -
3CEA
1
?
A:
[9-343]
-
L
R
A
A
I
I
G
-
L
G
-
R
L
G
E
-
R
-
H
A
R
H
L
V
N
KI
Q
--
G
V
K
L
V
A
A
C
A
L
D
S
N
Q
L
E
W
A
K
------
N
E
L
G
V
E
T
T
Y
T
N
Y
K
---
D
M
I
D
--------
T
---
E
-
N
I
D
A
I
F
I
V
A
P
T
P
F
H
P
E
M
T
I
Y
A
M
N
A
G
L
N
V
F
C
E
K
P
L
G
L
D
F
N
E
V
D
E
M
A
K
V
I
K
S
H
P
N
Q
I
F
Q
S
G
F
M
R
R
Y
D
D
S
Y
R
Y
A
K
K
I
V
D
N
G
D
-
I
---
G
K
I
I
Y
M
R
G
Y
G
I
D
P
I
S
---
G
-
M
E
S
F
T
K
F
A
T
E
A
-
D
S
G
G
I
F
V
D
M
N
I
H
D
I
D
L
I
R
W
F
T
G
Q
D
P
V
Q
-
A
Y
G
L
-------
T
S
NIAA
P
Q
L
A
D
I
G
E
F
E
T
G
V
A
Q
L
K
M
S
D
---
G
V
I
A
T
L
-
I
G
G
R
H
----
A
A
H
G
N
Q
V
E
L
--
E
-
V
---
M
G
S
N
G
W
V
R
I
-----------------------------------
G
EHPDLNR
V
T
V
F
N
DQ
G
---------------------
V
-------------------------
V
R
P
S
L
QS
F
G
-
E
-
R
F
D
T
A
F
T
D
E
V
Q
D
F
V
N
N
V
I
V
G
K
Q
--
P
EV-
T
V
D
D
G
I
K
A
L
K
I
A
K
A
C
Q
Q
S
A
N
I
G
K
-
L
V
D
I
Q
L
---------
61
HHSearch
58.81
16%
-87
- C1 -
3FHL
3
?
A:
[6-353]
-
I
K
T
G
L
A
A
-
F
G
-
M
S
G
Q
V
F
-
H
A
P
F
I
S
T
N-
P
--
H
F
E
L
Y
K
I
V
E
R
S
K
E
L
-
S
--
K
------
E
R
Y
P
Q
A
S
I
V
R
S
F
K
---
E
L
T
E
--------
D
---
P
-
E
I
D
L
I
V
V
N
T
P
D
N
T
H
Y
E
Y
A
G
M
A
L
E
A
G
K
N
V
V
V
E
K
P
F
T
S
T
T
K
Q
G
E
E
L
I
A
L
A
K
K
K
-
G
L
M
L
S
V
Y
Q
N
R
R
W
D
A
D
F
L
T
V
R
D
I
L
A
K
S
L
-
L
---
G
R
L
V
E
Y
E
S
T
F
A
R
Y
R
N
---
F
----------------
G
L
T
Y
N
L
G
S
H
L
I
D
Q
A
I
Q
L
F
G
M
-
P
E
A
-
V
F
A
D
L
G
ILREG
G
-----------
K
V
D
D
Y
F
I
I
H
L
L
H
P
S
LAP
N
V
K
I
T
L
-
K
A
S
Y
L
----
M
R
E
A
E
---
P
R
F
A
-
L
---
H
G
T
L
G
S
Y
V
K
-----------------------------------
Y
--------------
G
VPNWGEESEQE
W
G
L
L
H
T
E
I
NG
K
E
I
C
R
---------------------
K
---------
Y
P
G
I
A
G
N
Y
G
G
F
Y
Q
N
I
Y
E
H
L
C
L
G
Q
P
--
L
ET-
H
A
Q
D
I
L
N
V
I
R
I
I
E
A
A
Y
Q
S
H
R
E
N
K
-
I
V
N
L
-----------
57
HHSearch
57.73
16%
-76
- C1 -
3DB2
-
?
A:
[6-349]
-
V
G
V
A
A
I
G
-
L
G
-
R
W
A
Y
-
V
-
M
A
D
A
Y
T
K
--
S
E-
K
L
K
L
V
T
C
Y
S
R
T
E
D
K
R
E
K
F
G
------
K
R
Y
N
-
C
A
G
D
A
T
M
E
---
A
L
L
A
--------
R
---
E
-
D
V
E
M
V
I
I
T
V
P
N
D
K
H
A
E
V
I
E
Q
C
A
R
S
G
K
H
I
Y
V
E
K
P
I
S
V
S
L
D
H
A
Q
R
I
D
Q
V
I
K
E
T
-
G
V
K
F
L
C
G
H
S
S
R
R
L
G
A
L
R
K
M
K
E
M
I
D
T
K
E
-
I
---
G
E
V
S
S
I
E
A
V
F
S
N
E
R
G
---
L
E
L
K
K
G
N
W
R
G
E
P
A
T
A
P
G
G
P
L
T
Q
L
G
V
H
Q
I
D
N
L
Q
F
L
L
G
P
-
V
A
R
-
V
F
N
F
G
K
P
M
YTE
V
-----------
E
N
I
T
V
N
Q
T
L
L
E
F
E
D
---
G
K
Q
A
Y
L
-
G
T
N
W
A
----
C
P
G
V
F
---
S
I
-
N
-
V
---
Y
G
T
K
A
N
L
F
Y
-----------------------------------
Q
--------------
L
---------------------
D
FSWWSNSDVTDEH
S
T
L
I
K
R
E
FAS--
N
R
I
L
R
D
V
K
V
D
F
-
E
S
V
D
H
L
R
V
E
V
E
E
V
A
D
V
I
R
N
G
G
E
--
T
EI-
G
A
E
A
S
L
R
N
L
A
V
V
L
A
A
V
K
S
V
H
E
K
R
-
P
V
E
I
A
E
I
I
G
------