@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0917: (2015-12-19 )
MSSILTDFEPKFLSSDDLLNLYAEYCNGHYCDFKYKQRRLSDGNIQSHLYFKKDHFIHDYNGIETFKRFIAVKAYDVDNITSLALSNLLCEKFNLDILLTIEAMDKERALFFIRERKKRSKDISYQNIEYLEQMVSTDRAQIQKVSLSIMVFANSKKELDKKSIIVYNTLKKEGFSAVLESINMRPIFFSFFPERNFLNSRLRPQTSQNIASLIMFEKYQEGFKENSWGDCPVSVFKNQNGSAHFFNFQAKQGKDKNDNVVGHTMIIGSTGSGKSTFISFLIANLLTKYDMSVVALDRMNGLEIMTDFFEGQYNTANTDGGFYINPFSLKDSEENRQFLANWIKFMLNIDSDNQQDNKASQSIDKVIRDTYNYMGDQKNQINLLEIAKNLGSSEQDFNEILKSQGEKIYFKNFQDCLDFSNSPLSVINMDAFANDKKLMGLIAMYLFHKLFFEAKEHNKPFFYSLMKLKTTLCIL
Atome Classification :
(20 SA)
---.........10........20........30.......-.40.......-----.50........60-........-.70........80.......--..90-.........100...---....110.......120.......-130.......140..--.....150........160.......170.......180.......190--.....--------...200-.......210.-...---------....220....-----.---..-230......----.240---------.......250.......260--.-------------------........270.......280......---.290..----.....300...-....310....-...320......--.330.......-340.......350--------........--360......-----.370--.......380.......390--...--...-...400.....--..410.....----..420.....--..430----........440..-------.....450...-....460.......470...----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MS
S
I
L
TDFEPKFLSS
D
D
L
L
N
L
Y
A
E
Y
CNGHYCD
F
K
Y
K
Q
R-RLSDGNIQ
S
H
-----
L
Y
FKKDHFIHDY--N
G
I
E
T
F
K
R
-
F
I
A
V
K
A
YDV
D
N
I
-
T
S
L
A
L
S
N
--
L
L
C
--
E
KFN
L
D
I
L
L
T
I
EAMD---K
E
R
A
L
F
F
I
R
E
R
K
KRSKDISY
Q
N
I
E
-
Y
L
E
Q
M
V
S
T
D
R
A
Q
I
Q
K
--
V
S
L
S
I
M
V
-
F
ANSKKELDKK
S
I
I
V
Y
N
T
L
K
K
E
G
F
S
A
V
L
E
SINMR
P
I
F
F
S
F---FPER
N
--------
F
L
N
SRL-RPQ
T
S
Q
N
I
-
A
S
-
L
I
M
---------
F
E
K
Y
Q
E
GFKEN-----S---WG-DCP
V
S
V
F
KN----QNGS---------
A
H
F
F
N
F
QAKQGKDKND
N
V
----
V
-------------------
G
H
T
M
I
I
GSTGS
G
K
S
T
F
I
S
F
L
I
A
N
L
L
T
K
---YD
M
S
V
V
----
A
L
DRMN
G
L
E
I
M
-
T
D
F
FEGQYNTA-NTDG
G
F
Y
I
NPFS--LKD
S
E
E
N
R
Q
F
L
-
A
N
W
I
K
F
M
LNIDS---------DNQQD
N
K
A
--
S
Q
S
I
D
K
V
I
R
-----
D
T
Y
N
--YMGDQKNQ
I
N
L
L
E
I
A
K
NL----GS
S
--
E
Q
D
-
F
N
E
I
L
K
SQG
E
K
--
I
Y
F
K
N
F
Q
D
C
L
----DFSNSP
L
S
V
I
--
N
M
D
A-----FAN
D
K
K
L
M
G
L
I
A
M
-------
Y
L
F
H
K
L
F
F
E
A
K
-EHN
K
P
F
F
Y
S
L
M
K
L
K
T
T
LCIL----
57
Fugue
82.52
18%
-20
- C2 -
4C2E
-
CTPB_BACSU
A:
[2-436]
---------
A
D
S
E
R
D
K
A
M
D
K
I
E
K
A
Y
E
L
I
S
N
E
Y
V
--
E
K
V
D
R
E
-
K
L
L
E
G
A
I
Q
G
M
-----
L
S
T
L
N
D
P
Y
-
S
V
Y
--
M
D
K
Q
T
A
K
Q
-
F
S
D
S
L
D
S
S
F
E
G
I
G
A
E
V
G
M
E
D
G
K
I
I
I
--
V
S
P
F
K
K
S
P
A
E
K
A
G
L
K
---
P
N
D
E
I
I
S
I
N
G
E
S
M
A
G
K
D
L
N
H
A
V
L
K
-
I
R
G
K
K
G
S
S
V
S
M
K
I
Q
R
--
P
G
T
K
K
Q
L
-
S
F
R
I
K
R
A
E
I
P
L
E
T
V
F
A
S
E
K
K
V
Q
G
H
S
V
G
Y
I
A
I
S
T
----
F
S
E
---
H
T
T
E
D
--------
F
-
A
K
A
L
-
R
E
L
E
K
K
E
I
-
E
G
-
L
V
I
D
VRGNPGGY
I
Q
S
V
E
E
I
L
K
H
F
-----
V
---
T
K
-
D
Q
P
Y
I
Q
I
A
E
----
R
N
G
D
---------
K
K
R
Y
F
S
T
L
T
H
K
K
A
Y
P
V
N
V
----
I
T
D
KGSA
A
A
S
E
I
L
A
G
A
L
K
EA
G
H
Y
D
V
V
G
D
T
S
F
G
K
G
T
V
Q
Q
A
V
P
M
G
D
G
S
N
---
I
K
L
T
L
Y
----
K
W
L
T
P
N
G
N
W
I
H
-
K
K
G
I
E
P
T
I
A
I
--
K
Q
P
D
Y
F
S
A
G
P
L
Q
--
L
K
E
P
---------------
L
K
V
D
M
----------
N
N
E
D
V
K
H
--
A
Q
V
L
L
K
G
L
S
--------------------------
F
D
P
----
G
R
E
--
D
G
Y
-
F
S
K
D
M
K
K
A
V
M
A
--
F
Q
D
Q
N
-----------
K
L
N
K
T
G
I
I
--------------
D
T
R
T
A
E
T
L
N
Q
-------
Q
I
E
K
K
K
S
D
E
K
N
-
D
---------
L
Q
L
Q
T
A
L
K
S
L
F---
59
Fugue
79.80
20%
-51
- C6 -
4AV9
3
HSV2_KLULA
A:
[14-338]
---
S
N
P
I
V
--------------------------
D
Y
E
F
N
Q
D
--------
Q
S
C
-----
L
I
V
S
T
P
K
S
F
D
I
Y
--
N
-
V
H
P
L
K
R
-
I
M
S
Q
E
M
P
D
A
G
T
I
-
R
M
L
H
R
T
N
----------------
Y
I
A
F
V
S
---
T
K
K
E
L
L
H
I
W
D
D
V
K
K
-
Q
D
I
T
R
V
K
L
D
-----------
A
A
V
K
D
--
L
F
L
S
-------------
R
E
F
I
V
V
S
Q
-----------------
G
D
V
I
S
I
---
F
K
F
G
N
--------
P
W
N
----
K
I
T
E
D
I
K
F
-
G
G
-
V
C
E
---------
F
A
-------------------
N
-
G
L
L
V
Y
S
N
E
F
----
N
L
G
Q
---------
I
H
V
T
R
L
Q
-----
T
D
A
E
Q
V
----
V
-------------------
G
K
G
V
L
V
K
A
H
A
N
--------------------
P
V
K
M
V
----
R
L
N
R
------------
K
G
D
M
V
A
T
-
C
S
Q
D
G
T
L
I
R
V
F
Q
--
T
D
N
G
V
L
V
R
E
F
R
--------
R
G
L
D
R
---------
T
S
I
I
D
M
R
W
--
S
P
D
G
S
K
L
A
V
-----
V
S
D
K
--
W
------
T
L
H
V
F
E
V
F
N
D
A
----
E
N
K
--
R
H
V
-
L
K
D
W
I
N
S
E
W
S
I
--
C
N
F
K
-----
L
----
K
V
S
K
G
S
N
D
C
----
K
I
A
-----
W
I
S
D
T
---
G
L
V
I
V
-------
W
P
N
R
R
L
A
D
T
F
K
L
N
Y
N
D
D
E
H
V
W
W
L
Q
L
N
Q
R
N
E
I
P
----
63
Fugue
79.53
17%
-44
- C3 -
5D2E
3
?
A:
[5-510]
T
M
Q
I
E
Q
I
V
K
K
V
K
E
C
S
L
T
P
E
E
G
L
E
L
I
K
S
L
G
K
T
H
L
Y
E
M
V
W
D
R
H
-
E
F
K
G
S
K
K
F
P
H
TK
E
P
I
L
F
F
C
E
D
D
S
M
Y
T
V
M
K
R
Q
L
E
G
Y
E
A
P
F
I
Y
V
T
S
G
E
----------
R
F
--
E
D
C
--
R
N
G
R
F
T
M
N
F
T
-
K
G
E
D
---
Y
D
A
L
C
G
V
L
R
S
Q
N
I
R
P
R
H
I
I
H
F
L
A
A
G
L
F
K
N
T
E
D
A
M
R
K
Q
L
N
K
S
L
Y
S
L
F
Q
M
F
-
Q
A
F
M
A
N
K
L
C
P
K
A
E
I
L
Y
L
Y
E
N
A
E
G
--
E
V
Q
P
I
Y
N
A
V
E
S
F
L
K
T
---
V
Q
A
E
N
PN
F
T
C
K
A
A
E
L
K
S
M
F
D
E
P
F
T
K
Q
H
I
-
A
D
-
V
I
S
---------
F
E
W
N
N
--------------------
C
F
T
C
Y
E
P
----
R
-------------
H
Y
Y
K
R
Q
L
Q
R
V
K
K
S
F
S
V
K
----
K
-------------------
N
G
V
Y
L
I
T
----
G
G
A
G
G
L
G
Y
L
F
A
E
Y
L
A
K
---
Q
A
E
V
K
L
----
I
L
T
---
G
R
S
P
A
-
S
R
E
T
A
Q
K
L
S
A
L
E
N
L
G
A
E
A
L
Y
V
P
A
D
--
I
S
K
E
K
E
T
D
A
L
I
-
K
Y
I
K
Q
T
F
G
E
L
N
G
I
L
H
S
A
G
L
V
K
D
A
F
I
I
K
K
T
--
K
E
S
I
E
E
V
I
A
PK
V
F
G
T
V
W
L
--
D
K
A
A
E
E
E
P
L
D
F
F
V
M
F
S
S
L
----
S
A
V
LP
N
A
G
-
Q
S
D
Y
A
F
A
N
G
C
M
--
D
G
F
T
Q
Y
R
S
M
K
----
G
R
P
G
K
T
L
S
I
N
WP
L
W
D
A
-----
G
A
L
R
H
A
G
L
E
L
L
S
A
-------
Q
A
G
L
A
A
F
Q
D
S
M
-
S
R
S
A
S
Q
L
A
V
I
S
G
D
K
D
R
I
S
E
L
L
S--
62
Fugue
76.34
17%
-57
- C3 -
4XGC
1
ORC5_DROME
E:
[1-458]
---
M
E
A
I
C
S
S
L
E
P
L
F
P
C
R
E
A
A
I
E
T
L
G
E
L
I
G
D
-------------
S
S
E
T
Y
P
S
A
-----
I
Y
L
F
G
----
H
S
G
--
T
G
K
T
A
L
T
R
-
A
F
L
K
E
C
G
K
R
Q
N
V
-
R
T
A
H
L
N
A
--
I
E
C
YT
T
K
I
M
L
E
I
L
L
D
S
L
A
P
D
---
Q
G
D
A
L
K
V
------------
D
N
M
L
D
-
F
V
E
Q
L
R
R
Q
A
A
T
R
V
E
D
--
Q
G
F
L
I
A
V
D
N
A
E
R
L
R
D
M
D
A
N
V
L
P
V
L
L
R
L
Q
E
L
T
------
N
L
N
L
C
V
I
L
L
S
Q
---
L
P
F
E
K
--------
F
Y
N
------
K
T
G
L
S
E
-
I
V
-
C
L
H
---------
L
A
Q
Y
N
K
A
E
T
Q
R
-----
I
---
L
G
S
D
F
Q
Q
V
R
N
Q
L
----
L
E
Q
K
---------
K
R
L
E
I
C
Q
E
A
V
T
E
D
F
Y
N
N
Y
----
L
-------------------
N
L
F
L
S
V
F
Y
K
A
C
R
D
V
P
E
L
Q
L
T
A
R
K
C
L
S
T
---
Y
L
E
P
V
L
---------
D
G
T
S
R
L
-
W
R
H
I
A
G
P
L
R
S
A
-
L
T
Q
I
Y
M
R
I
E
S
L
E
--
L
P
-------
Y
Y
-
A
K
F
L
L
I
A
A
F
L
A
S
---------
H
N
A
A
K
Q
D
K
--
R
L
F
S
T
T
L
G
P
-----
K
S
F
S
---------
I
D
R
L
L
A
I
F
Y
A
I
----
L
E
E
--
K
V
G
-
L
T
C
N
L
L
S
Q
I
S
T
--
L
V
H
L
N
L
---
L
----
S
F
V
S
G
E
Q
N
I
M
--
E
G
S
A
----------
R
L
Q
C
T
I
G
L
-------
E
F
V
L
Q
I
G
K
V
V
G
-
F
N
V
R
Q
Y
L
C
D
---------------
58
Fugue
70.71
11%
-38
* C5 *
3VS8
2
?
A:
[7-410]
-HP
N
S
A
V
L
A
D
F
I
P
V
Q
L
A
K
P
V
P
Q
R
I
T
L
E
L
T
A
Y
G
F
A
R
A
H
C
L
S
N
G
I
T
D
E
E
G
F
V
Q
V
-----
Y
K
T
V
K
E
K
F
D
K
Y
A
--
V
S
P
A
Q
I
K
Q
-
R
Q
L
V
Y
F
P
K
L
T
D
I
-
R
--------------
F
G
D
G
N
F
D
I
A
D
P
E
P
D
---
Q
A
H
L
R
L
F
D
I
K
K
D
P
R
G
A
D
L
K
T
R
H
E
S
-
Y
A
K
V
V
G
K
G
L
E
Q
M
F
----------------
E
G
T
L
E
A
P
D
D
L
I
H
V
T
C
S
---------
G
Y
L
A
P
S
P
A
E
R
M
---
V
A
D
R
G
--------
W
F
E
T
T
V
-
T
H
S
Y
N
M
G
C
Y
G
A
-
F
P
A
---------
I
K
M
A
H
G
M
L
A
S
A
-----
Q
---
W
G
-
A
T
P
-----------------------------------
P
K
T
R
V
D
----
I
-------------------
A
H
T
E
L
M
S
A
H
N
N
I
A
E
S
R
V
D
N
I
I
S
A
T
L
F
S
---
D
G
L
I
K
Y
----
S
V
Y
P
E
D
E
L
R
R
Q
G
L
R
G
L
R
I
L
A
M
S
E
-
H
L
------------
L
P
D
S
A
D
T
M
T
G
V
-
P
G
S
H
Q
F
V
M
T
L
S
P
---------
L
--
V
P
A
I
I
--
K
R
H
V
R
A
F
A
V
-----
D
L
L
R
--
R
A
G
------------
M
D
F
----
E
R
D
--
K
D
A
-
L
S
F
A
I
H
P
G
G
P
K
--
I
-
V
D
H
V
Q
E
E
L
----
G
L
A
E
D
Q
V
-
A
I
--
S
K
S
V
-----
F
L
E
N
G
N
M
S
S
S
T
I
P
-------
H
I
L
K
A
Y
L
E
E
A
T
-
V
G
T
R
I
A
C
L
G
F
G
P
G
L
T
A
A
G
L
V
L
E
K
I
56
Fugue
70.10
21%
6
* C6 *
4U6D
22
?
A:
[28-409]
-EG
F
P
F
I
L
P
K
E
K
P
N
R
P
L
S
A
A
M
Q
R
N
Y
D
N
Y
----------
M
A
P
-
R
P
E
N
N
E
L
Y
T
Q
-----
F
K
Y
T
E
L
K
G
F
-
D
Y
--
N
G
-------------
H
D
-
G
T
I
-
S
R
R
D
P
S
K
--
V
I
Y
--
E
N
------------
G
---
K
Y
Y
V
W
Y
T
Y
R
N
T
P
T
P
P
Q
G
A
K
N
S
N
-----
D
T
I
P
S
A
D
W
--------
D
L
A
E
I
W
-
Y
A
T
S
K
----------------
D
G
F
T
W
E
E
Q
G
--------
V
A
---
V
P
R
P
P
--------
K
P
N
V
G
W
-
R
S
V
T
T
T
D
I
-
L
K
W
K
G
K
---------
F
Y
L
Y
Y
Q
G
F
M
E
A
-----
S
GTR
G
D
-
D
C
P
V
A
V
S
Y
A
----
D
S
P
D
---------
G
P
W
--------
T
P
H
T
E
V
V
----
I
-------------------
P
N
G
K
K
G
E
W
D
Q
Y
S
I
H
D
P
Y
P
I
V
Y
K
D
K
I
Y
L
---
Y
Y
K
S
D
F
DGDP
N
L
V
R
M
Q
G
L
A
I
A
-
D
-----------
N
P
L
G
P
F
K
K
S
P
L
N
PV
I
N
S
G
H
E
T
T
L
F
P
-
F
K
E
G
M
A
A
L
V
I
R
D
---------
G
T
E
H
N
--------------------
T
V
Q
--
Y
A
E
D
G
V
N
-
F
N
I
A
S
I
V
E
F
M
PNAA
G
P
Y
--
V
A
D
A
F
T
N
T
K
Y
G
R
G
I
S
W
G
I
S
H
F
T
N
A
T
T
W
----
D
Q
N
H
A
V
L
A
R
F
--
D
C
D
L
SLDVD
D
P
H
M
K
R
L
G
T
Y
F
K
P
-------
E
F
Y
Y
Q
M
G
L
S
K
K
-
Q
R
E
R
I
-------------------
61
Fugue
60.61
12%
-8
- C3 -
3AFV
2
?
A:
[4-442]
--------
T
I
L
P
L
N
N
I
Q
G
D
I
L
V
G
M
K
K
Q
--
K
E
R
F
V
F
F
Q
V
N
D
A
-
T
S
F
K
T
A
L
K
T
Y
-----
V
P
E
R
------------
I
T
S
A
A
I
-
L
I
S
D
P
S
Q
Q
P
L
A
F
-
V
N
L
G
F
S
N
--
T
G
L
--
Q
A
L
G
I
T
D
D
L
G
D
A
Q
F
P
DGQ
F
A
D
A
A
N
L
G
D
D
L
S
Q
W
V
A
P
F
T
G
T
T
I
H
-
G
V
F
L
I
G
S
D
Q
D
D
F
L
D
Q
--
F
T
D
D
I
S
S
-
T
F
G
S
S
---------
I
T
Q
V
Q
A
L
S
G
S
A
R
P
G
D
Q
A
G
H
E
H
F
G
F
L
D
GI
S
Q
P
S
V
T
--------
G
W
E
T
T
V
-
F
P
G
Q
A
V
V
P
-
P
G
-
I
I
L
---------
T
G
R
D
G
D
T
G
T
R
P
-----
S
---
W
A
L
D
G
S
F
M
A
F
R
H
----
F
Q
Q
K
---------
V
P
E
F
N
A
Y
T
L
A
N
A
I
P
--------------------------------
A
N
S
A
G
N
L
T
Q
Q
E
G
A
E
F
L
G
A
R
M
F
G
R
---
W
K
-------------
S
G
A
P
I
D
-
L
A
P
T
A
D
D
P
A
L
G
-
A
D
P
Q
R
N
N
N
F
D
Y
S
--
D
T
L
T
D
E
T
R
C
P
F
-
G
A
H
V
R
K
T
--------------
N
P
R
Q
D
L
G
G
--
P
V
D
T
F
H
A
M
R
-----
S
S
I
P
--
Y
----
G
P
E
T
S
D
A
E
L
A
S
G
V
----
T
A
Q
--
D
R
G
-
L
L
F
V
E
Y
Q
S
I
I
G
--
N
G
F
R
F
Q
Q
I
N
W
ANNA
N
F
P
F
S
K
P
I
T
P
--
G
I
E
P
-----
I
I
G
Q
T
T
P
R
T
V
G
G
L
DPLNQNE
T
F
T
V
P
L
F
V
I
P
K
-
G
G
E
Y
F
F
L
P
S
I
S
A
L
T
A
T
I
A
A
-----
65
Fugue
56.75
10%
-18
- C5 -
4DZI
6
?
A:
[4-394]
---------
A
L
N
Y
R
V
I
D
V
D
N
H
Y
Y
E
P
L
D
S
F
T
R
H
L
------
D
K
-
K
F
K
R
R
G
V
Q
M
L
-----
S
D
-
G
K
R
T
W
A
V
I
G
--
D
R
V
N
H
F
I
P
-
N
P
T
F
D
P
I
I
V
P
G
C
-
L
D
L
L
F
R
G
--
E
I
P
--
D
G
V
D
P
A
S
L
M
K
V
E
R
L
A
---
D
H
P
E
Y
Q
---
N
R
D
A
R
I
A
V
M
D
E
Q
D
I
E
-
T
A
F
M
L
P
T
F
G
C
G
V
E
E
A
--
L
K
---------
H
D
I
E
A
T
M
A
S
V
H
A
F
N
L
W
L
D
E
D
W
G
F
D
R
P
D
H
R
I
I
A
A
P
I
V
S
---
L
A
D
P
T
--------
R
A
V
E
E
V
-
D
F
V
L
A
R
G
A
-
K
L
-
V
L
V
---------
R
P
-------------------
A
-
P
V
P
G
L
V
K
P
R
----
S
L
G
D
---------
R
S
H
D
P
V
W
A
R
L
A
E
A
-----------------------------
G
V
P
V
G
F
H
L
S
D
S
G
Y
L
H
I
A
A
A
W
G
G
K
--
A
K
---
D
P
L
D
Q
V
----
L
L
D
D
R
A
I
H
D
T
M
-
A
S
M
I
V
H
G
V
F
T
R
-
H
P
K
L
K
A
V
S
I
E
N
G
--
S
------------
Y
F
V
H
R
L
I
K
R
L
K
---------
K
A
A
N
T
Q
P
Q
YF
P
E
D
P
V
E
Q
L
R
-----
N
N
V
W
IA
P
Y
Y
E
D
D
L
P
E
L
A
R
V
I
G
V
D
K
----
I
L
F
--
G
S
D
-
W
P
H
G
E
G
L
A
S
P
V
--
S
F
T
A
E
L
K
G
--------------------
F
S
-----
E
S
D
I
R
K
I
M
R
D
N
A
L
-------
D
L
L
G
--------------------------------
18
PsiBlast_PDB
44.92
30%
-2
- C4 -
2EWV
1
?
A:
[54-157]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
-
T
P
E
D
T
Q
K
L
-
A
Y
-
S
V
M
---------
S
E
K
H
R
Q
K
L
E
E
N
G
Q
V
D
F
S
---
F
G
-
V
R
G
V
G
R
F
R
A
N
V
F
Y
Q
R
G
S
V
A
A
A
L
R
S
L
P
A
E
I
P
E
F
K
K
L
G
L
P
D
K
V
L
E
L
C
H
RK
M
-------------------
G
L
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
I
D
Y
I
N
Q
T
---
K
S
Y
H
I
I
----
T
I
E
D
P
I
E
Y
V
F
K
-
H
K
K
S
I
V
N
Q
R
E
V
-
G
E
D
T
K
S
F
A
D
A
L
R
--
A
A
L
R
E
D
P
D
V
I
F
-
V
G
E
M
R
D
L
E
T
V
E
T
---------
A
L
R
A
A
E
T
G
--
H
L
V
F
G
T
L
H
T
-----
N
T
A
I
--
D
T
I
H
R
I
V
D
I
F
P
L
N
Q
Q
E
Q
V
----
R
I
V
--
L
S
F
-
I
L
Q
G
I
I
S
Q
R
L
L
--
P
K
I
G
G
G
R
V
L
A
----
Y
E
L
L
I
P
N
T
A
I
--
R
N
L
I
-----
R
E
N
K
L
Q
Q
V
Y
S
L
M
Q
-------
M
Q
T
M
N
Q
T
L
Y
K
L
-
Y
K
Q
G
L
I
T
L
E
D
A
M
E
A
S
P
D
P
K
E
----
31
HHSearch
44.31
12%
7
- C4 -
1E9R
2
?
A:
[35-164]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
A
K
---------
Q
V
T
V
A
G
V
P
M
P
R
----
D
A
E
----
P
-------------------
R
H
L
L
V
N
G
A
T
G
T
G
K
S
V
L
L
R
E
L
A
Y
T
G
L
L
R
----
G
D
R
M
V
----
I
V
D
P
N
G
D
M
L
S
K
-
F
G
R
D
K
D
I
I
L
N
P
-
Y
D
Q
R
T
K
G
W
S
F
F
N
--
E
I
R
N
D
Y
D
W
Q
R
Y
A
L
S
V
V
P
R
G
K
T
-
D
E
---------
A
E
E
W
A
S
Y
G
--
R
L
L
L
R
E
T
A
K
-----
K
L
A
L
--
I
G
T
P
S
M
R
E
L
F
H
W
T
T
I
A
T
F
----
D
D
L
--
R
G
F
-
L
E
G
T
L
A
E
S
L
F
A
--
G
S
N
E
A
S
K
A
L
T
----
S
A
R
F
V
L
S
D
K
L
--
P
E
H
V
-----
T
M
P
D
G
D
F
S
I
R
S
W
L
-------
E
D
P
N
G
G
N
L
F
I
T
-
W
R
E
D
M
G
P
A
L
R
P
L
I
S
A
W
V
D
V
V
----
33
HHSearch
43.31
26%
-27
- C4 -
2IUS
-
FTSK_ECOLI
A:
[966-1026]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
D
----
I
A
G
E
---------
P
V
V
A
D
L
A
K
--------------
M
-------------------
P
H
L
L
V
A
G
T
T
G
S
G
A
S
V
G
V
N
A
M
I
L
S
M
L
Y
K
AQP
E
D
V
R
F
I
----
M
I
D
P
K
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
42.21
22%
-23
- C4 -
2IUT
2
FTSK_PSEAE
A:
[195-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
A
L
G
H
D
----
I
G
G
R
---------
P
I
I
T
D
L
A
K
--------------
M
-------------------
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
STP
S
E
A
R
L
I
----
M
I
D
P
K
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
40.93
43%
-21
- C4 -
2OUK
1
?
B:
[53-87]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
--
N
L
L
E
D
---
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
A
K
D
-
T
N
L
N
K
V
R
E
E
V
G
-
M
V
F
Q
R
F
N
L
F
P
H
M
--
T
V
L
N
N
I
T
L
A
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
---------
K
A
M
E
L
L
D
K
--
V
G
L
K
D
K
A
H
A
-----
Y
P
D
S
--
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
----
P
K
I
--
M
L
F
-
D
E
P
T
S
A
L
D
P
E
M
--
V
G
E
V
L
S
V
M
K
Q
----
L
A
N
E
G
M
T
M
V
V
--
V
T
H
E
-----
M
G
F
A
R
E
V
G
D
R
V
L
F
-------
M
D
G
G
Y
I
I
E
E
G
K
-
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
----
28
PsiBlast_CBE
39.97
43%
-22
- C4 -
2OLK
1
?
C:
[53-87]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
--
N
L
L
E
D
---
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
A
K
D
-
T
N
L
N
K
V
R
E
E
V
G
-
M
V
F
Q
R
F
N
L
F
P
H
M
--
T
V
L
N
N
I
T
L
A
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
---------
K
A
M
E
L
L
D
K
--
V
G
L
K
D
K
A
H
A
-----
Y
P
D
S
--
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
----
P
K
I
--
M
L
F
-
D
E
P
T
S
A
L
D
P
E
M
--
V
G
E
V
L
S
V
M
K
Q
----
L
A
N
E
G
M
T
M
V
V
--
V
T
H
E
-----
M
G
F
A
R
E
V
G
D
R
V
L
F
-------
M
D
G
G
Y
I
I
E
E
G
K
-
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
----
5
PsiBlast_PDB
39.69
43%
-20
- C4 -
2OLK
1
?
A:
[53-87]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
--
N
L
L
E
D
---
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
A
K
D
-
T
N
L
N
K
V
R
E
E
V
G
-
M
V
F
Q
R
F
N
L
F
P
H
M
--
T
V
L
N
N
I
T
L
A
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
---------
K
A
M
E
L
L
D
K
--
V
G
L
K
D
K
A
H
A
-----
Y
P
D
S
--
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
----
P
K
I
--
M
L
F
-
D
E
P
T
S
A
L
D
P
E
M
--
V
G
E
V
L
S
V
M
K
Q
----
L
A
N
E
G
M
T
M
V
V
--
V
T
H
E
-----
M
G
F
A
R
E
V
G
D
R
V
L
F
-------
M
D
G
G
Y
I
I
E
E
G
K
-
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
----
30
PsiBlast_CBE
39.67
43%
-14
- C4 -
2OLJ
2
?
B:
[53-87]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
--
N
L
L
E
D
---
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
A
K
D
-
T
N
L
N
K
V
R
E
E
V
G
-
M
V
F
Q
R
F
N
L
F
P
H
M
--
T
V
L
N
N
I
T
L
A
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
---------
K
A
M
E
L
L
D
K
--
V
G
L
K
D
K
A
H
A
-----
Y
P
D
S
--
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
----
P
K
I
--
M
L
F
-
D
E
P
T
S
A
L
D
P
E
M
--
V
G
E
V
L
S
V
M
K
Q
----
L
A
N
E
G
M
T
M
V
V
--
V
T
H
E
-----
M
G
F
A
R
E
V
G
D
R
V
L
F
-------
M
D
G
G
Y
I
I
E
E
G
K
-
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
----
23
PsiBlast_CBE
39.07
43%
-17
- C4 -
2Q0H
2
?
B:
[53-87]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
--
N
L
L
E
D
---
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
A
K
D
-
T
N
L
N
K
V
R
E
E
V
G
-
M
V
F
Q
R
F
N
L
F
P
H
M
--
T
V
L
N
N
I
T
L
A
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
---------
K
A
M
E
L
L
D
K
--
V
G
L
K
D
K
A
H
A
-----
Y
P
D
S
--
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
----
P
K
I
--
M
L
F
-
D
E
P
T
S
A
L
D
P
E
M
--
V
G
E
V
L
S
V
M
K
Q
----
L
A
N
E
G
M
T
M
V
V
--
V
T
H
E
-----
M
G
F
A
R
E
V
G
D
R
V
L
F
-------
M
D
G
G
Y
I
I
E
E
G
K
-
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
----
25
PsiBlast_CBE
38.89
43%
-18
- C4 -
2OUK
1
?
C:
[53-87]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
--
N
L
L
E
D
---
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
A
K
D
-
T
N
L
N
K
V
R
E
E
V
G
-
M
V
F
Q
R
F
N
L
F
P
H
M
--
T
V
L
N
N
I
T
L
A
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
---------
K
A
M
E
L
L
D
K
--
V
G
L
K
D
K
A
H
A
-----
Y
P
D
S
--
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
----
P
K
I
--
M
L
F
-
D
E
P
T
S
A
L
D
P
E
M
--
V
G
E
V
L
S
V
M
K
Q
----
L
A
N
E
G
M
T
M
V
V
--
V
T
H
E
-----
M
G
F
A
R
E
V
G
D
R
V
L
F
-------
M
D
G
G
Y
I
I
E
E
G
K
-
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
----
4
PsiBlast_PDB
38.83
43%
-16
- C4 -
2OLJ
2
?
A:
[53-87]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
--
N
L
L
E
D
---
F
D
E
G
E
I
----
I
I
D
G
I
N
L
K
A
K
D
-
T
N
L
N
K
V
R
E
E
V
G
-
M
V
F
Q
R
F
N
L
F
P
H
M
--
T
V
L
N
N
I
T
L
A
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
---------
K
A
M
E
L
L
D
K
--
V
G
L
K
D
K
A
H
A
-----
Y
P
D
S
--
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
----
P
K
I
--
M
L
F
-
D
E
P
T
S
A
L
D
P
E
M
--
V
G
E
V
L
S
V
M
K
Q
----
L
A
N
E
G
M
T
M
V
V
--
V
T
H
E
-----
M
G
F
A
R
E
V
G
D
R
V
L
F
-------
M
D
G
G
Y
I
I
E
E
G
K
-
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
----
14
PsiBlast_PDB
38.78
47%
9
- C4 -
4HUQ
-
ECFA2_LACBA
A:
[34-67]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
--
N
A
L
L
K
---
P
T
S
G
T
I
----
K
I
D
E
F
T
I
T
P
E
T
-
T
N
A
A
L
K
P
L
R
Q
H
-
V
G
M
V
F
Q
F
P
E
N
Q
L
--
F
E
E
T
V
R
Q
D
I
A
F
-
G
P
K
N
F
G
M
A
D
A
D
A
---------
L
A
L
A
D
E
M
L
--
T
T
V
G
L
D
Q
S
Y
-----
A
E
R
S
--
P
F
E
L
S
G
G
Q
M
R
R
V
A
I
A
G
V
L
----
A
M
Q
--
P
K
V
-
L
V
L
D
E
P
T
A
G
L
D
--
P
Q
G
R
Q
E
M
M
R
L
----
F
A
R
L
H
Q
E
Q
G
L
--
T
I
V
L
-----
V
T
H
Q
M
E
D
V
A
Q
Y
A
E
-------
Q
V
A
V
M
H
E
G
R
L
M
-
K
F
G
T
P
A
D
V
F
S
N
R
E
W
L
Q
D
H
Q
L
----