@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0060: (2016-03-11 )
MNKTIEMDGTTYDFTYEDLVWSITFPKSKTRAKELAQLELLEKPATHFTPAKISSDSDSYTISYEIAPRTYGFEQVRKMGREDKLRALRNIADLGELLNTRYTFFLHPDNLIFDINLVPSIVHRGIKNILPPYELTEETFFKQYQCFVIAMFSKKFSFENLYNGSLSGARGTQFEKSILDAKTVQDIATILEEAYMKEHAAVQKNMASVPKKKYSTFRGLAVGFIIVAILLAIPVSYFAFVKVPLQNDLLTANENFLKTDYDKVITGLENVDPEKMPQSVQYELAYSYVKGEKMSDKKKENIMNTISLKSDAKNLLYWIYNGRGEFSKSLDIAKLLDDPTLAMYSLTKQIEQVQSDTTLSGDEKVEKLKTLEESLKEYDEKVNESTTTEDETTNTEAK
Atome Classification :
(20 SA)
---------------------------........-.10....-....20........30--....-....40....-.....50....---....60........--70....-.---.----..80....-----..-..90...-....--.--100......-.110-...-----....120....-...130.......140.......150.......160-......-----------.170....-...180.....-..------------------------------190....-...200.......210-......-.--220-.......230.......240.......250.......260.......270----------.......280--........-----.290-........300-------........310.......320.....-..330........340.......350.......360.......-.370.......380........390......-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------MNK
T
I
EMD-G
T
T
Y
D
F
T
-
Y
E
D
L
V
W
S
I
TFPKS
K
T
R
--
A
K
E
L
-
A
Q
L
E
L
-LEKP-ATHFTPAKISS---DSD
S
Y
T
I
S
Y
E
IAPR--TY
G
F
E
Q
-
V
---
R
----KMG
R
E
D
K
L
-----
R
A
-
L
R
N
I
A
D
L
-
G
E
L
L--N--T
R
Y
T
F
F
LHP-D
N
L
I
-
F
DI-----N
L
V
P
S
I
V
H
R
G
I
-
K
NILPPYEL
T
E
E
T
F
F
K
Q
Y
Q
C
F
V
I
A
M
F
SKKFSFENLY-NGSLSG-----------ARGT
Q
F
E
K
-
S
IL
D
A
K
T
V
Q
D
I
-
A
T
------------------------------
I
L
E
E
A
Y
M
-
K
E
H
A
A
V
Q
K
N
M
A
SV
P
K
K
-
K
Y
S
T
F
R
-
G
--
L
A
V
-
G
F
I
I
V
A
I
L
L
A
I
P
V
S
Y
F
A
F
V
KVPLQNDLLTANEN
F
L
K
T
D
Y
D
K
V
I
T
G
LENV
D
----------
P
E
KM
P
Q
S
V
----
Q
Y
E
L
A
Y
S
Y-----VKG--EKMS
D
K
K
K
E
N
--------
I
M
N
T
ISLKSDAK
N
L
L
Y
W
I
YNGRGEFS-KSL-
D
I
A
K
LLDDP
T
L
A
M
Y
S
L
T
K
Q
I
E
Q
V
QSDTTLS-
G
D
E
K
V
E
K
L
-
K
T
L
E
E
S
L
K
E
Y
D
E
K-VNESTTTEDETTNTEAK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
84.40
32%
-113
- C6 -
4ANN
-
?
A:
[30-205]
------------------------------------------------
L
D
M
R
E
I
P
K
S
S
I
K
--
P
E
H
F
-
H
L
M
Y
L
-
L
E
Q
H
-
S
P
Y
F
I
D
A
E
L
T
E
---
L
R
D
S
F
Q
I
H
Y
D
I
N
D
N
--
H
T
P
F
D
N
-
I
---
K
----
S
F
T
K
N
E
K
L
-----
R
Y
-
L
L
N
I
K
N
L
-
E
E
V
N
--
R
--
T
R
Y
T
F
V
L
A
P
-
D
E
L
F
-
F
T
R
-----
D
G
L
P
I
A
K
T
R
G
L
-
Q
N
V
V
D
P
L
P
V
S
E
A
E
F
L
T
R
Y
K
A
L
V
I
C
A
F
N
E
K
Q
S
F
D
A
L
V
-
E
G
N
L
E
L
-----------
H
K
G
T
P
F
E
T
-
K
V
I
E
A
A
T
L
D
L
L
-
T
A
------------------------------
F
L
D
E
Q
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.48
33%
-109
- C6 -
4ANN
-
?
A:
[36-205]
------------------------------------------------------
P
K
S
S
I
K
--
P
E
H
F
-
H
L
M
Y
L
-
L
E
Q
H
-
S
P
Y
F
I
D
A
E
L
T
E
---
L
R
D
S
F
Q
I
H
Y
D
I
N
D
N
--
H
T
P
F
D
N
-
I
---
K
----
S
F
T
K
N
E
K
L
-----
R
Y
-
L
L
N
I
K
N
L
-
E
E
V
N
--
R
--
T
R
Y
T
F
V
L
A
P
-
D
E
L
F
-
F
T
R
-----
D
G
L
P
I
A
K
T
R
G
L
-
Q
N
V
V
D
P
L
P
V
S
E
A
E
F
L
T
R
Y
K
A
L
V
I
C
A
F
N
E
K
Q
S
F
D
A
L
V
-
E
G
N
L
E
L
-----------
H
K
G
T
P
F
E
T
-
K
V
I
E
A
A
T
L
D
L
L
-
T
A
------------------------------
F
L
D
E
Q
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
76.56
40%
-42
- C6 -
2YNQ
5
?
A:
[6-154]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
K
Q
E
A
Y
I
Q
S
T
E
L
F
L
Q
N
K
Y
S
D
V
I
T
T
L
E
D
Y
A
----------
P
E
D
M
P
Y
V
I
----
Q
Y
E
L
A
S
S
Y
-----
V
M
T
--
E
S
L
T
E
E
Q
R
Q
T
--------
V
S
N
N
I
T
L
K
T
D
E
Q
Y
M
L
Y
W
I
Y
I
G
R
S
Q
S
E
-
E
A
L
-
E
L
A
R
T
I
E
D
R
D
L
I
V
Y
A
L
L
K
Y
R
E
Q
I
K
G
D
T
D
L
S
-
G
D
E
K
Q
K
K
L
-
D
E
I
D
Q
E
I
K
E
Y
E
R
E
-
R
K
E
S
E
A
Q
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
76.11
39%
-42
- C6 -
2YNQ
5
?
A:
[6-154]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
K
Q
E
A
Y
I
Q
S
T
E
L
F
L
Q
N
K
Y
S
D
V
I
T
T
L
E
D
Y
A
----------
P
E
D
M
P
Y
V
I
----
Q
Y
E
L
A
S
S
Y
-----
V
M
T
--
E
S
L
T
E
E
Q
R
Q
T
--------
V
S
N
N
I
T
L
K
T
D
E
Q
Y
M
L
Y
W
I
Y
I
G
R
S
Q
S
E
-
E
A
L
-
E
L
A
R
T
I
E
D
R
D
L
I
V
Y
A
L
L
K
Y
R
E
Q
I
K
G
D
T
D
L
S
-
G
D
E
K
Q
K
K
L
-
D
E
I
D
Q
E
I
K
E
Y
E
R
E
-
R
K
E
S
E
A
Q
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.05
21%
-98
- C6 -
4ANO
2
?
A:
[22-213]
----------------------------------------------
D
Q
P
Y
T
V
I
F
Q
R
A
K
L
K
--
M
Q
D
P
-
L
E
L
E
V
-
L
-
K
E
-
V
D
P
C
I
V
R
D
I
D
V
---
S
E
D
E
V
K
V
V
I
K
P
P
S
S
--
F
L
T
F
A
A
-
I
---
R
----
K
T
T
L
L
S
R
I
-----
R
A
A
I
H
L
V
S
K
V
-
K
H
H
S
--
A
--
R
R
L
I
F
I
V
C
P
-
E
N
L
M
-
F
N
R
-----
A
L
E
P
F
F
L
H
V
G
V
-
K
E
S
L
P
P
D
E
W
D
D
E
R
L
L
R
E
V
K
A
T
V
L
A
L
T
E
G
E
Y
R
F
D
E
-
Y
-
L
K
F
H
E
T
-----------
L
K
C
S
P
I
A
K
-
E
L
W
Q
A
D
H
L
D
A
V
-
L
A
------------------------------
V
L
E
K
-
W
V
-
D
E
E
E
A
K
E
R
A
K
V
H
I
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
73.87
20%
-86
- C6 -
4ANO
2
?
A:
[5-213]
----------------------------
S
E
K
K
T
Y
L
-
E
T
Q
L
D
A
V
M
I
N
D
Q
P
Y
T
V
I
F
Q
R
A
K
L
K
M-
Q
D
P
L
-
E
L
E
V
L
-
K
E
---
V
D
P
C
I
V
R
D
I
D
V
---
S
E
D
E
V
K
V
V
I
K
P
P
S
S
--
F
L
T
F
A
A
-
I
---
R
----
K
T
T
L
L
S
R
I
-----
R
A
-
A
I
H
L
V
S
K
V
K
H
H
S
--
A
--
R
R
L
I
F
I
V
C
P
-
E
N
L
-
M
F
N
R
-----
A
L
E
P
F
F
L
H
V
G
V
-
K
E
S
L
P
P
D
E
W
D
D
E
R
L
L
R
E
V
K
A
T
V
L
A
L
T
E
G
E
Y
R
F
D
E
Y
L
-
K
F
-
H
E
T
-----------
L
K
C
S
P
I
A
K
-
E
L
W
Q
A
D
H
L
D
A
V
-
L
A
------------------------------
V
L
E
K
W
V
D
-
E
E
E
A
K
E
R
A
-
K
V
H
I
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_CBE
73.33
42%
-45
- C6 -
2YNQ
3
?
C:
[7-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
Q
E
A
Y
I
Q
S
T
E
L
F
L
Q
N
K
Y
S
D
V
I
T
T
L
E
D
Y
A
----------
P
E
D
M
P
Y
V
I
----
Q
Y
E
L
A
S
S
Y
-----
V
M
T
--
E
S
L
T
E
E
Q
R
Q
T
--------
V
S
N
N
I
T
L
K
T
D
E
Q
Y
M
L
Y
W
I
Y
I
G
R
S
Q
S
E
-
E
A
L
-
E
L
A
R
T
I
E
D
R
D
L
I
V
Y
A
L
L
K
Y
R
E
Q
I
K
G
D
T
D
L
S
-
G
D
E
K
Q
K
K
L
-
D
E
I
D
Q
E
I
K
E
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_CBE
73.31
42%
-44
- C6 -
2YNQ
4
?
D:
[7-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
Q
E
A
Y
I
Q
S
T
E
L
F
L
Q
N
K
Y
S
D
V
I
T
T
L
E
D
Y
A
----------
P
E
D
M
P
Y
V
I
----
Q
Y
E
L
A
S
S
Y
-----
V
M
T
--
E
S
L
T
E
E
Q
R
Q
T
--------
V
S
N
N
I
T
L
K
T
D
E
Q
Y
M
L
Y
W
I
Y
I
G
R
S
Q
S
E
-
E
A
L
-
E
L
A
R
T
I
E
D
R
D
L
I
V
Y
A
L
L
K
Y
R
E
Q
I
K
G
D
T
D
L
S
-
G
D
E
K
Q
K
K
L
-
D
E
I
D
Q
E
I
K
E
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_CBE
73.04
42%
-51
- C6 -
2YNQ
3
?
B:
[7-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
Q
E
A
Y
I
Q
S
T
E
L
F
L
Q
N
K
Y
S
D
V
I
T
T
L
E
D
Y
A
----------
P
E
D
M
P
Y
V
I
----
Q
Y
E
L
A
S
S
Y
-----
V
M
T
--
E
S
L
T
E
E
Q
R
Q
T
--------
V
S
N
N
I
T
L
K
T
D
E
Q
Y
M
L
Y
W
I
Y
I
G
R
S
Q
S
E
-
E
A
L
-
E
L
A
R
T
I
E
D
R
D
L
I
V
Y
A
L
L
K
Y
R
E
Q
I
K
G
D
T
D
L
S
-
G
D
E
K
Q
K
K
L
-
D
E
I
D
Q
E
I
K
E
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.04
42%
-45
- C6 -
2YNQ
5
?
A:
[7-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
Q
E
A
Y
I
Q
S
T
E
L
F
L
Q
N
K
Y
S
D
V
I
T
T
L
E
D
Y
A
----------
P
E
D
M
P
Y
V
I
----
Q
Y
E
L
A
S
S
Y
-----
V
M
T
--
E
S
L
T
E
E
Q
R
Q
T
--------
V
S
N
N
I
T
L
K
T
D
E
Q
Y
M
L
Y
W
I
Y
I
G
R
S
Q
S
E
-
E
A
L
-
E
L
A
R
T
I
E
D
R
D
L
I
V
Y
A
L
L
K
Y
R
E
Q
I
K
G
D
T
D
L
S
-
G
D
E
K
Q
K
K
L
-
D
E
I
D
Q
E
I
K
E
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
71.93
17%
4
- C5 -
4PKF
4
?
A:
[8-864]
-----------------------------
K
V
L
E
Y
K
-
G
K
K
L
N
F
T
-
P
E
D
-------
P
A
E
E
T
I
--
P
A
D
--
E
L
H
E
H
-
L
Q
K
P
-
S
T
A
R
T
K
R
L
K
E
R
---
C
R
W
K
H
A
S
A
G
E
F
I
E
K
S
V
T
A
G
I
E
R
-
M
---
R
----
Y
L
T
E
A
H
K
A
S
EGKP
E
A
-
I
R
R
A
L
G
L
-
A
N
V
L
--
N
--
K
S
-
T
L
V
L
Q
E
-
D
E
F
I
-
V
G
Y
------------
H
A
E
D
-
P
N
M
F
P
L
Y
P
E
L
S
H
M
A
V
Q
D
Y
L
---------------------------------------
R
S
D
Y
-
S
P
Q
P
A
D
E
A
A
A
I
-
N
E
------------------------------
Y
W
K
P
H
S
L
-
Q
S
K
C
Q
P
Y
F
D
P
A
D
L
G
R
M
Y
Q
V
S
S
M
E
-
A
PS
F
A
S
-
G
Y
N
S
I
V
P
P
Y
E
T
V
L
E
D
G
L
L
A
R
I
K
L
A
E
K
H
I
A
E
A
Q
A
D
M
S
T
F
P
W
N
G
T
K
G
L
D
N
I
A
----------
K
I
D
N
W
K
A
M
----
V
I
A
C
K
A
V
I
-----
S
W
A
--
R
R
Q
G
R
L
C
K
I
V
--------
A
E
N
F
E
T
D
P
K
R
Q
A
E
L
L
E
I
A
D
I
C
Q
R
I
P
A
-
E
P
C
-
K
G
L
K
D
A
M
Q
A
K
F
F
T
F
L
I
C
H
A
I
E
R
Y
A
S
G
-----------------------
Y
A
Q
K
-
E
D
T
L
L
W
P
Y
Y
K
A
S
V
V
D
K
K
FQPMS
H
M
D
A
V
E
L
V
E
M
E
R
L
K
I
S
E
HGAGKS
R
A
Y
R
E
I
F
PGSN
D
L
F
I
L
T
V
G
GTNAKGEDACN
D
M
T
D
A
I
L
E
A
A
K
R
IRTAEP
S
I
V
F
RYSKKNR
E
K
T
L
R
W
V
F
E
C
I
R
D
GLGYP
S
I
K
H
D
E
I
G
T
E
Q
M
K
E
Y
A
K
F
SLNGNGAT
D
E
E
A
H
NWVNVLC
M
S
P
G
I
H
G
RRKTQKTRSE
G
G
G
S
I
F
P
A
K
L
L
E
I
S
L
N
D
GYDWSYADMQLGPKTGDLSSLKS
F
E
D
V
W
E
A
F
R
K
Q
Y
Q
Y
A
I
N
L
C
I
S
T
K
D
V
S
R
Y
F
E
Q
R
FLQM
P
F
V
S
A
I
D
D
G
C
M
E
L
GMDACALSE
Q
P
N
G
W
H
N
P
I
T
T
I
V
A
A
N
S
L
V
A
I
K
K
LVFEEKKYT
L
E
Q
L
S
Q
A
L
K
A
N
WEGF
E
E
M
R
V
D
F
K
R
APKWGNDD
D
Y
A
D
G
I
I
T
R
F
Y
E
EI
I
G
G
E
M
R
K
ITNYSG
G
P
V
M
P
TGQAVG
L
Y
M
E
V
G
S
R
TGPTPDGRFGGEAADDGGISPYMGTDKKG
P
T
A
V
L
R
S
V
S
K
VQKNQK
G
N
L
L
N
Q
R
L
S
V
P
I
M
R
SKH
G
F
E
I
W
N
S
Y
I
K
T
W
H
D
L
NID
H
V
Q
F
N
VVS
T
D
E
M
R
A
A
Q
R
EPEKHHD
L
I
V
R
V
S
GYSARFVDIP
T
Y
G
Q
N
T
I
I
A
RQE
Q
D
F
S
A
S
D
L
E
F
L
NVEI
47
Fugue
59.05
18%
-17
- C2 -
4RGL
1
?
A:
[8-335]
---------------------------------------
Y
Q
P
P
-
Y
T
I
---
T
P
A
I
V
N
L
V
A
E
--
I
G
E
I
-
I
G
R
Y
T
-
V
L
A
E
-
Q
N
L
T
P
R
L
R
R
E
N
---
R
I
R
T
I
Q
A
S
L
A
I
E
N
N
--
T
L
T
L
E
Q
-
V
---
T
----
A
V
I
D
G
K
-------
R
V
-
L
G
H
P
R
E
I
-
Q
E
V
R
--
N
--
A
F
A
T
Y
--
E
A
M
E
D
W
D
-
A
S
V
-----
E
G
D
L
L
A
A
H
E
L
L
M
R
G
------
L
V
D
E
T
-------------------
G
R
Y
R
-
S
G
G
V
G
I
-----------
F
R
G
E
Q
L
V
H
M
A
-
P
P
A
D
R
V
P
K
L
M
A
D
------------------------------
L
L
D
W
L
E
N
T
N
E
H
P
L
V
A
S
C
I
F
H
Y
E
F
E
-
F
I
H
P
F
A
D
G
--
N
G
R
M
G
R
L
W
Q
T
L
I
L
R
N
W
K
P
L
L
A
Y
L
P
V
----------
E
T
V
I
R
D
R
Q
E
D
Y
Y
R
V
L
A
V
A
D
----------
S
Q
------------
A
D
A
T
P
F
-----
V
E
F
M
L
G
A
L
R
D
A
V
R
E
A
--------
V
S
T
D
H
Q
V
T
D
Q
V
A
A
L
I
R
A
I
--
G
G
G
E
L
S
S
N
D
L
M
Q
A
L
G
L
S
H
R
P
T
F
R
N
N
Y
L
N
P
-----------
A
M
E
D
E
W
I
E
R
T
-
Q
P
D
S
P
R
-----------
S
P
T
Q
R
Y
R
L
T
G
K
G
Q
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
55.21
15%
-37
- C4 -
4F3V
6
ECCA1_MYCTU
A:
[1-275]
---------------------------
G
H
M
T
D
R
L
A
-
S
L
F
E
S
A
V
-
S
M
-------
L
P
M
S
E
A
R
--
S
L
D
L
F
T
E
I
T
N
-
Y
D
E
S
-
A
C
D
A
W
I
G
R
I
R
C
---
G
D
T
D
R
V
T
L
F
R
A
W
Y
S
--
R
R
N
F
G
Q
-
L
---
S
----
G
S
V
Q
I
S
-
M
-----
S
T
-
L
N
A
R
I
A
I
-
G
G
L
Y
--
G
--
D
-
I
T
Y
P
V
-
T
-
S
P
L
A
-
I
T
M
-----
G
F
A
A
C
E
A
A
Q
G
----------------------------
N
Y
A
D
A
M
E
A
L
E
-
A
A
P
V
A
G
S----------
E
H
L
V
A
W
M
K
-
A
V
V
Y
G
A
-
A
E
R
W
-
T
D
------------------------------
V
I
D
Q
V
----------
K
S
A
G
K
W
P
D
K
-
F
L
A
G
A
A
-
G
--
V
A
H
-
G
V
A
A
A
N
L
A
L
-----------------------------
F
T
E
A
E
R
R
L
T
E
A
N
----------
D
S
P
A
G
E
A
C
----
A
R
A
I
A
W
Y
L
-----
A
------
M
A
R
R
S
Q
G
N
---------------
E
S
A
A
V
A
L
L
E
W
L
Q
T
T
H
P
E
-----
P
-
K
V
A
A
A
L
K
D
P
S
Y
R
L
K
T
T
T
--------------------------
A
E
Q
I
A
S
R
A
D
P
-
W
D
P
G
S
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
51.16
12%
-12
- C3 -
2AR0
7
T1MK_ECOLI
A:
[6-529]
N
D
L
V
A
K
L
W
K
L
C
D
N
L
R
D
G
GVSYQN
Y
V
N
E
L
A
S
L
L
F
L
K
M
C
K
E
T
G
Q
E
-
A
E
Y
L
P
E
G
Y
R
W
D
D
L
K
S
R
IG
Q
E
Q
L
-
Q
F
Y
R
K
M
L
V
H
L
-
G
E
D
D
K
K
L
V
Q
A
V
---
F
H
N
V
S
T
T
I
T
E
P
K
Q
I
--
T
A
L
V
S
N
M
D
---
S
----
L
D
W
Q
Y
F
T
P
-----
R
P
-
L
I
K
T
--
I
-
I
H
L
L
--
K
--
P
Q
------
P
-
R
E
V
V
-
Q
D
P
AAGTA
G
F
L
I
E
A
D
R
Y
V
K
-
S
Q
T
N
D
L
D
D
L
D
G
D
T
Q
D
F
Q
I
H
R
A
F
I
G
L
E
L
V
P
G
T
R
R
L
A
L
M
N
C
L
L
H
D
IEGNLDHGGA
I
R
L
G
N
T
L
G
S
-
D
G
E
N
L
P
K
A
H
I
V
-
A
T
N
P
P
FGSAAGTNITRTFVHPTSN
K
Q
L
C
F
M
Q
H
I
I
E
T
L
H
P
-
G
G
R
A
A
V
V
V
P
D
N
V
L
F
E
G
-
G
K
G
T
D
I
-
R
--
R
D
L
M
D
K
C
H
L
H
T
I
L
R
L
P
T
G
I
F
Y
A
Q
G
V
K
T
N
V
L
F
F
T
K
G
T
V
A
N
P
N
Q
D
K
N
C
T
D
D
V
W
V
Y
D
LRTNMPSFGK
R
T
P
F
T
D
E
H
----
L
Q
P
F
E
R
V
Y
-----
G
E
D
--
P
H
G
L
S
P
R
T
E
G
--------
E
W
S
F
N
A
E
E
T
E
V
A
D
S
E
E
N
K
--
N
T
D
Q
H
L
-
A
T
S
-
R
W
R
K
F
S
R
E
W
I
R
T
A
K
S
D
S
L
D
I
S
W
L
K
D
K
D
P
-
E
-
P
D
V
L
A
A
E
A
M
G
E
L
V
Q
A
L
S
E
L
D
A
L
M
R
E
L
G
A
S
D
E
A
D
L
Q
R
Q
L
L
E
E
A
FGGV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
51.01
27%
-50
- C6 -
4EQB
-
?
A:
[60-192]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
I
P
S
E
Y
M
--
I
N
K
M
K
D
E
D
L
L
------
V
P
L
D
Y
S
K
-
I
E
G
I
E
N
I
G
----------
P
E
F
L
N
Q
S
F
DPGN
K
F
S
I
P
Y
F
W
G
T
L
G
I
V
Y
N
--
E
T
M
V
D
E
A
P
E
H
W
D
D
L
W
KLE
Y
K
N
S
I
M
L
F
D
G
A
R
E
V
L
G
L
G
L
N
S
L
G
Y
S
L
-
N
S
K
-
D
-
P
Q
Q
L
E
E
T
V
D
K
L
Y
K
L
T
P
N
I
K
A
I
V
A
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
50.09
14%
-36
- C6 -
3FE3
-
MARK3_HUMAN
A:
[102-200]
-------------------------------------------------------------------
R
E
V
R
I
-
M
K
I
L
-
N
H
P
N
I
-
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
--
G
E
V
F
D
Y
-
L
V
A
H
G
----
R
M
K
E
K
E
A
R
-----
S
K
-
F
R
Q
I
V
S
A
-
V
Q
Y
C
H
Q
K
--
R
I
V
H
R
D
L
K
A
-
E
N
L
L
-
L
D
A
-----
D
M
N
I
K
I
A
D
F
G
F
-
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
46.01
14%
-14
- C6 -
3TKI
2
CHK1_HUMAN
A:
[54-153]
-------------------------------------------------------------------
K
E
I
C
I
-
N
K
M
L
-
N
H
E
N
V
-
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
--
G
E
L
F
D
R
-
I
---
E
PDI-
G
M
P
E
P
D
A
Q
-----
R
F
-
F
H
Q
L
M
A
G
-
V
V
Y
L
H
G
I
--
G
I
T
H
R
D
I
K
P
-
E
N
L
L
-
L
D
E
-----
R
D
N
L
K
I
S
D
F
G
L
-
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
45.87
12%
-13
- C6 -
2Y7J
1
PHKG2_HUMAN
A:
[149-248]
--------------------------------------------------------------------
E
T
H
I
-
L
R
Q
V
A
G
H
P
H
I
-
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
--
G
E
L
F
D
Y
-
L
---
T
E
K
V-
A
L
S
E
K
E
T
R
-----
S
I
-
M
R
S
L
L
E
A
-
V
S
F
L
--
H
A
N
N
I
V
H
R
D
L
K
P
-
E
N
I
L
-
L
D
D
-----
N
M
Q
I
R
L
S
D
F
G
F
-
S
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
45.62
15%
-20
- C6 -
3A8X
-
KPCI_HUMAN
A:
[69-164]
-------------------------------------------------------------------------------
H
P
F
L
-
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
--
G
D
L
M
F
H
-
M
---
Q
R
Q
R-
K
L
P
E
E
H
A
R
-----
F
Y
-
S
A
E
I
S
L
A
-
L
N
Y
L
H
E
R
--
G
I
I
Y
R
D
L
K
L
-
D
N
V
L
-
L
D
S
-----
E
G
H
I
K
L
T
D
Y
G
M
-
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
45.59
13%
-39
* C6 *
3SXS
1
A:
[53-152]
--------------------------------------------------------------------
E
A
Q
T
-
M
M
K
L
-
S
H
P
K
L
-
V
K
F
Y
G
VCS
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
--
G
C
L
L
N
Y
-
L
---
R
S
HGK
G
L
E
P
S
Q
L
L
-----
E
M
-
C
Y
D
V
C
E
G
-
M
A
F
L
E
S
H
--
Q
F
I
H
R
D
L
A
A
-
R
N
C
L
-
V
D
R
-----
D
L
C
V
K
V
S
D
F
G
M
-
T
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------