@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0233: (2016-03-13 )
MAKAKRTTKFVCQACGYESAKWMGKCPNCNEWNQMVEALEPSKKSRSAFNHTGEPSKATPITQIASETEKRVETNMPELNRVLGGGVVPGSMVLVGGDPGIGKSTLLLQVSAQLTLTNKKVLYISGEESIKQTKLRAERLQVSGDNLYVYAETNLEAVQETIDFVKPDFVVIDSIQTVYHSDVTSAAGSVSQVRECTATLMRIAKMQNIAIFIVGHVTKEGAIAGPRLLEHMVDTVLYFEGERHHAYRILRAVKNRFGSTNEMGIFEMRDVGLVEVANPSEVFLEERLEGASGSTVVASMEGTRPVLVEIQALVSPTMFGNAKRMATGIDYNKVSLIMAVLEKRVGLMLQNQDAYLKAAGGVKLDEPAVDLAVAVSVASSYRDKPTRSTDCFIGELGLTGEIRRVARIEQRVQEAAKLGFKRIFIPKNNEGNWKIPKDVQVVGVETIGEALKKALPD
Atome Classification :
(20 SA)
------.........10........20...------.....30........40.......-.50.--..--.....60....--....70........80........90........100.......110...----------------.------.-..120..------....--.--130..--------..--...140.----.-----...-----------------------.----------------------.150---------.-----...-------.---.-------.---160---.----.---.--...--------.------.170.......180..---.---....190.......200......-.210...--..-----..220-----....---...230.......-------240...--....250.......-260........270........280-...-----------....290.-------......300.-......310....----------...-320...-....----.330---..----......340---......------.350..---....-..-360-.-..-.....----.370.......380.......390.......400-------------------------------........410.......420.......430..-----..----..----.----440.......450.....-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MAKA
K
R
T
T
K
F
V
C
Q
ACGYES
A
K
WMG------KCP
N
C
N
E
W
N
Q
M
V
E
A
LEPSKKSRSA-FNHT--GE--PSKAT
P
I
T
Q
I
A
--
S
E
T
E
K
R
VETN
M
P
E
L
N
R
V
LGGGVVPG
S
M
V
L
VGGDPGIGK
S
T
L
L
L
Q
V
S
A
Q
L
T
----------------L------T-N
K
K
V
L
Y
I------SG
E
E
--
S
--
I
K
Q
T
K
--------
L
R
--
A
E
R
L
Q
VS----G-----D
N
L
-----------------------
Y
----------------------
V
Y
AE---------T-----
N
L
E
-------
A
---
V
-------
Q
---
E
T
----
I
----
D
---F--VKP--------
D
------
F
V
V
I
D
S
I
Q
T
V
Y
HSD
V
T
---S---AA
G
S
V
S
Q
V
R
E
C
T
A
T
L
M
R
I
A
KMQ
N
-
I
A
I
F
I
V
G
--HV-----TKEGA-----IA
G
P
---
R
L
L
E
H
M
V
D
T
V
L
Y
F-------EGE
R
H
H
--
A
Y
R
I
L
R
A
V
K
N
RFGS-TN-EM
G
I
F
E
M
RD-V
G
L
V
EVA
N
P
S
E
V
-
F
L
E
-----------
E
R
LEGASG-------
S
T
V
V
A
SMEGT-
R
P
V
L
V
E
I
Q
A
L
VS
P
----------
T
MF-GN-
A
K
R
-
M
ATG----ID
Y
----
N
K
----
V
S
L
I
M
A
V
L
E
---
K
R
V
G
L
M
------LQ-NQD---
A
Y
L
K-AA-G---G-VK-LDEPA----
V
D
L
A
V
A
V
S
V
A
S
S
YRDKPTRSTD
C
F
I
GELGL
T
G
E
--------------------------------
I
R
R
V
A
R
I
E
Q
R
V
Q
E
A
A
KLG
F
K
R
I
F
I
PKNNEGNWK-----IP----K
D
----
V
----
Q
V
V
G
V
E
T
I
G
E
A
L
K
K
ALPD-----
42
HHSearch
75.96
20%
-84
- C1 -
2I1Q
4
RADA_METVO
A:
[15-321]
-------------
T
A
E
K
L
V
E
A
G
Y
I
D
F
M
K
I
A
------
T
A
T
V
----
G
E
L
T
D
I
E
G
I
S
E
K
A
A
A
K
M
I
M
G
A
--
R
D
L
C
D
L
G
F
K
S
G
I
D
L
L
K
Q
R
S
T
V
W
K
L
S
T
S
S
S
E
L
D
S
V
L
G
G
G
L
E
S
Q
S
V
T
E
F
A
G
V
F
G
S
G
K
T
Q
I
M
H
Q
S
C
V
N
L
Q
NPEF
L
F
Y
D
EEAVSKGE
V
------
A
-
Q
P
K
A
V
Y
I
------
D
T
E
G
TF
R
--
P
E
R
I
M
--------
Q
M
--
A
E
H
A
G
I
D
G
Q
T
V
L
-----
D
N
T
-----------------------
F
----------------------
V
A
R
A
---------
Y
-----
N
S
D
M
Q
M
L
F
A
E
K
---
I
-------
E
---
D
L
----
I
----
Q
---
E
G-
N
N
I
--------
K
------
L
V
V
I
D
S
L
T
S
T
F
R
N
E
Y
T
---
G
RGK
L
A
E
R
Q
Q
K
L
G
R
H
M
A
T
L
N
K
L
A
D
L
F
N
-
C
V
V
L
V
T
N
--
Q
V
-----
S
A
K
--A
E
Q
--
A
I
G
G
---
H
I
V
G
H
A
A
T
F
R
F
F
V
-------
R
K
G
K
-
G
--
D
K
R
V
A
K
L
Y
D
S
P
H
L
P
-
D
--
A
E
A
I
F
R
I
T
E
-
K
G
I
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
75.05
23%
-98
- C1 -
2CVH
-
RADB_THEKO
A:
[1-220]
-----------------------------------------------------------------------------------------
M
L
S
T
G
T
K
S
L
D
S
L
L
G
G
G
F
A
P
G
V
L
T
Q
V
Y
G
P
Y
A
S
G
K
T
T
L
A
L
Q
T
G
L
L
S
--------------------------
G
K
K
V
A
Y
V
DTEGGF
S
P
E
R
--
L
--
V
Q
M
A
E
--------
T
R
--
G
L
N
P
E
E
A
----
L
-----
S
R
F
-----------------------
I
----------------------
L
F
T
P
---------
S
-----
D
F
K
-------
E
---
Q
-------
R
---
R
V
----
I
----
G
---
S
--
L
K
K
TVDSNF--
A
------
L
V
V
V
D
S
I
T
A
H
Y
R
A
E
E
N
---
R
---
S
-
G
L
I
A
E
L
S
R
Q
L
Q
V
L
L
W
I
A
R
K
H
N
-
I
P
V
I
V
I
N
--
Q
V
H
FDSR
T
E
M
T
K
-----
P
V
A
E
---
Q
T
L
G
Y
R
C
K
D
I
L
R
L
-------
D
K
L
P
K
P
--
G
L
R
V
A
V
L
E
R
H
R
F
R
P
-
E
G
-
L
M
A
Y
F
R
I
T
E
-
R
G
I
E
D
V
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
73.82
22%
-95
- C1 -
2CVH
-
RADB_THEKO
A:
[2-219]
------------------------------------------------------------------------------------------
L
S
T
G
T
K
S
L
D
S
L
L
G
G
G
F
A
P
G
V
L
T
Q
V
Y
G
P
Y
A
S
G
K
T
T
L
A
L
Q
T
G
---
L
----------------
L
------
S
-
G
K
K
V
A
Y
V
DTEGGF
S
P
E
R
--
L
--
V
Q
M
A
E
--------
T
R
--
G
L
N
P
E
E
A
----
L
-----
S
R
F
-----------------------
I
----------------------
L
F
T
P
---------
S
-----
D
F
K
-------
E
---
Q
-------
R
---
R
V
----
I
----
G
---
S
--
L
K
K
--------
T
VDSNFA
L
V
V
V
D
S
I
T
A
H
Y
R
A
E
-
E
---
N
---
R
S
G
L
I
A
E
L
S
R
Q
L
Q
V
L
L
W
I
A
R
K
H
N
-
I
P
V
I
V
I
N
Q
V
H
F
-----
D
S
R
T
E
-----
M
T
K
P
VAE
Q
T
L
G
Y
R
C
K
D
I
L
R
L
-------
D
K
L
P
K
P
--
G
L
R
V
A
V
L
E
R
H
R
F
R
P
-
E
G
-
L
M
A
Y
F
R
I
T
E
-
R
G
I
E
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
72.25
23%
-88
- C1 -
2CVH
-
RADB_THEKO
A:
[1-219]
-----------------------------------------------------------------------------------------
M
L
S
T
G
T
K
S
L
D
S
L
L
G
G
G
F
A
P
G
V
L
T
Q
V
Y
G
P
Y
A
S
G
K
T
T
L
A
L
Q
T
G
L
L
-------------------------
S
-
G
K
K
V
A
Y
V
------
D
T
E
G
GF
S
--
P
E
R
L
V
--------
Q
M
--
A
E
T
R
G
L
N
----
P
E
E
A
L
-
S
R
F
-----------------------
I
----------------------
L
F
T
P
---------
S
-----
D
F
K
-------
E
---
Q
-------
R
R
V
I
G
S
----
L
----
K
KTV
D
--
S
N
F
--------
A
------
L
V
V
V
D
S
I
T
A
H
Y
R
A
E
E
N
-------
R
S
G
L
I
A
E
L
S
R
Q
L
Q
V
L
L
W
I
A
R
K
H
N
-
I
P
V
I
V
I
N
--
Q
V
-----
H
F
D
S
R
TEMTK
P
V
A
E
---
Q
T
L
G
Y
R
C
K
D
I
L
R
L
-------
D
K
L
P
K
P
--
G
L
R
V
A
V
L
E
R
H
R
F
R
P
-
E
G
-
L
M
A
Y
F
R
I
T
E
-
R
G
I
E
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
69.49
19%
-92
- C1 -
2W0M
5
?
A:
[3-231]
----------------------------------------------------------------------------------------
S
R
L
S
T
G
I
L
D
F
D
K
L
I
Q
G
G
I
P
Q
G
F
F
I
A
L
T
G
E
P
G
T
G
K
T
I
F
S
L
H
F
I
A
K
G
L
----------------
R
------
D
-
G
D
P
C
I
Y
V
------
T
T
E
E
--
S
--
R
D
S
I
I
--------
R
Q
--
A
K
Q
F
N
W
D
----
F
EEYIE
K
K
L
-----------------------
I
----------------------
I
I
D
A
LMDQWSLVN
L
-----
T
P
E
-------
E
---
L
-------
V
---
N
K
----
V
I
E
A
K
Q
---
K
L
G
Y
G
K
--------
A
------
R
L
V
I
D
S
V
S
A
L
F
L
D
K
P
-------------
A
M
A
R
K
I
S
Y
Y
L
K
R
V
L
N
K
W
N
-
F
T
I
Y
A
T
S
--
Q
------------------------
G
V
E
H
V
A
D
G
I
I
R
F
-------
R
R
M
I
R
N
G
E
L
H
R
Y
I
L
I
E
K
M
R
Q
T
D
-
H
D
K
H
V
W
E
I
D
I
V
N
G
K
G
I
V
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.37
22%
-90
- C1 -
2CVF
-
RADB_THEKO
A:
[2-219]
------------------------------------------------------------------------------------------
L
S
T
G
T
K
S
L
D
S
L
L
G
G
G
F
A
P
G
V
L
T
Q
V
Y
G
P
Y
A
S
G
K
T
T
L
A
L
Q
T
G
---
L
----------------
L
------
S
-
G
K
K
V
A
Y
V
D
TEGGF
S
P
E
R
--
L
--
V
Q
M
A
E
--------
T
R
--
G
L
N
P
E
E
A
----
L
-----
S
R
F
-----------------------
I
----------------------
L
F
T
P
---------
S
-----
D
F
K
-------
E
---
Q
-------
R
---
R
V
----
I
----
G
---
S
--
L
K
K
--------
T
VDSN
F
A
L
V
V
V
D
S
I
T
A
H
Y
R
A
E
-
E
---
N
---
R
S
G
L
I
A
E
L
S
R
Q
L
Q
V
L
L
W
I
A
R
K
H
N
-
I
P
V
I
V
I
N
QV
H
F
-----
D
S
R
T
E
-----
M
T
K
P
VAE
Q
T
L
G
Y
R
C
K
D
I
L
R
L
-------
D
K
L
P
K
P
--
G
L
R
V
A
V
L
E
R
H
R
F
R
P
-
E
G
-
L
M
A
Y
F
R
I
T
E
-
R
G
I
E
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
68.39
23%
-96
- C1 -
2DR3
2
Y284_PYRHO
A:
[3-238]
----------------------------------------------------------------------------------------
R
R
V
K
T
G
I
P
G
V
D
E
I
L
H
G
G
I
P
E
R
N
V
V
L
L
S
G
G
P
G
T
G
K
T
I
F
S
Q
Q
F
L
W
N
G
L
----------------
K
------
M
-
G
E
P
G
I
Y
V
------
A
L
E
E
--
H
--
P
V
Q
V
R
--------
Q
N
--
M
A
Q
F
G
W
D
----
V
-----
K
P
Y
E
E
K
GM
F
A
M
V
D
AFTAGIGKEYEKY
I
----------------------
V
H
D
L
---------
T
-----
D
I
R
-------
E
---
F
-------
I
---
E
V
----
L
R
Q
A
I
R
---
D
--
I
N
A
--------
K
------
R
V
V
V
D
S
V
T
T
L
Y
I
N
K
P
-------------
A
M
A
R
S
I
I
L
Q
L
K
R
V
L
A
G
T
G
-
C
T
S
I
F
V
S
--
Q
V
-----
S
---------
G
F
G
----
P
G
V
E
H
G
V
D
G
I
I
R
L
-------
D
L
D
E
I
D
G
E
L
K
R
S
L
I
V
W
K
M
R
G
T
S
-
H
S
M
R
R
H
P
F
D
I
T
D
-
K
G
I
I
V
Y
P
D
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.69
22%
-102
- C1 -
4B3C
2
RADA_PYRFU
A:
[6-190]
-----------------------------------------------------------------------------------------
R
I
S
T
G
S
K
S
L
D
K
L
L
G
G
G
I
E
T
Q
A
I
T
E
V
F
G
E
F
G
S
G
K
T
Q
L
A
H
T
L
A
V
M
V
Q
----------------
L
PPEEGG
L
-
N
G
S
V
M
W
I
------
D
T
E
N
--
T
--
F
R
P
E
R
--------
I
R
E
I
A
Q
N
R
G
L
D
----
P
-----
D
E
V
-----------------------
L
K
H
I
-------------------
A
Y
A
R
---------
A
FN
S
N
H
Q
M
L
-------
L
---
V
-------
Q
---
Q
A
----
E
----
D
---
M
--
I
K
E
L
LNTDRPV
K
------
L
L
I
V
D
S
L
T
S
H
F
R
S
E
Y
I
GRG
A
---
L
A
E
R
Q
Q
K
L
A
K
H
L
A
D
L
H
R
L
A
N
L
Y
D
-
I
A
V
F
V
T
N
--
Q
V
-----
Q
A
N
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
66.10
17%
-85
- C1 -
1V5W
-
DMC1_HUMAN
A:
[83-338]
------------------------------------------------------------------------
P
G
F
L
T
A
F
E
Y
S
E
K
R
K
M
V
F
H
I
T
T
G
S
Q
E
F
D
K
L
L
G
G
G
I
E
S
M
A
I
T
E
A
F
G
E
F
R
T
G
K
T
Q
L
S
H
T
L
C
V
T
A
Q
----------------
L
PGAGGY
P
-
G
G
K
I
I
F
I
------
D
T
E
N
TF
R
--
P
D
R
L
R
--------
D
I
--
A
D
R
F
N
V
D
H
D
A
V
L
-----
D
N
V
-----------------------
L
----------------------
Y
A
R
A
---------
Y
-----
T
S
E
-------
H
Q
M
E
L
-------
L
---
D
Y
V
A
A
K
F
----
H
E
E-
A
--
G
I
F
--------
K
------
L
L
I
I
D
S
I
M
A
L
F
R
V
D
F
S
---
G
RGE
L
A
E
R
Q
Q
K
L
A
Q
M
L
S
R
L
Q
K
I
S
E
E
Y
N
-
V
A
V
F
V
T
N
--
Q
M
------------------
G
---
H
I
L
A
H
A
S
T
T
R
I
S
L
-------
R
K
G
R
G
---
E
L
R
I
A
K
I
Y
D
S
P
E
M
P
-
E
N
--
E
A
T
F
A
I
T
A
-
G
G
I
G
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
64.54
14%
-58
- C2 -
3M6A
1
LON1_BACSU
A:
[7-531]
TGEVQ
T
L
T
E
K
I
E
E
A
G
M
P
D
H
V
K
E
T
A
L
K
E
L
N
R
YEKIPS
S
S
A
E
S
S
V
I
R
N
Y
I
D
W
L
V
A
L
P
W
T
D
E
T
-
D
D
K
L
--
D
L
--
K
E
A
G
R
L
L
D
E
E
H
--
H
G
L
E
K
V
K
E
R
I
L
E
Y
L
A
V
Q
K
L
T
K
S
L
K
G
P
I
L
C
L
A
G
P
P
G
V
G
K
T
S
L
A
K
S
I
A
K
S
L
G
-------------------------
R
K
F
V
R
I
S
------
L
G
G
R
--
I
--
I
Q
G
M
K
K
A
GKLN
P
V
F
L
--
L
D
E
I
D
K
M
----
S
-----
A
M
L
-----------------------
E
----------------------
V
L
D
P
---------
E
-----
Q
N
S
-------
S
---
F
-------
S
---
D
H
----
Y
----
I
---
E
--
E
T
F
--------
D
LSK
V
L
-
F
I
A
T
A
N
N
L
A
T
I
P
G
P
L
R
---
D
---
R
M
E
I
I
N
I
A
G
Y
T
E
I
E
K
L
E
I
V
K
D
H
L
-
L
P
K
Q
I
K
E
--
H
G
-----
L
K
K
S
N
-----
L
------
Q
L
R
D
Q
A
I
L
D
I
I
R
Y
YTREAGV
R
S
L
E
R
Q
--
L
A
A
I
C
R
K
A
A
K
A
I
V
A
-
E
E
-
R
K
R
I
-
T
V
T
E
-
K
N
L
Q
D
F
I
G
K
R
I
F
R
Y
G
Q
-----------
A
E
T
E
D
Q
V
G
-------
V
V
T
G
L
A
Y
T
T
V
-
G
G
D
T
L
S
I
E
V
S
L
S
P
--------------
G
K
-
G
K
L
-
I
L
T
G
KLG
D
V
M
R
----
E
S
----
A
Q
A
A
F
S
Y
V
R
---
S
K
T
E
E
L
GIEPDF
H
E
-
K
Y
D
---
I
H
I
H
V
P
E
-
G
---
A
-
V
P
-
K
D
G
P
A
----
A
G
I
T
M
A
T
A
L
V
S
A
L
T
G
R
A
V
S
R
E
V
G
M
T
G
E
I
T
L
R
G
R
--------------------------------
V
L
P
I
G
G
L
K
E
K
A
L
G
A
H
R
A
G
L
T
T
I
I
A
P
K
D
N
E
K
D
I
E
D----
I
P
----
E
S
----
V
R
E
G
L
T
F
I
L
A
S
H
L
D
E
V
L
E
H
A
L
V
------
7
PsiBlast_PDB
64.24
25%
-83
- C2 -
1Z0C
-
LONB_ARCFU
A:
[441-602]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
P
I
I
A
E
V
T
P
----------
S
M
-----
E
G
R
V
I
A
T
G
RL
Q
E
I
A
R
----
E
A
----
V
M
N
V
S
A
I
I
K
---
K
Y
T
G
R
D
------
I
S
-
N
M
D
---
V
H
I
Q
-
F
V
-
G
---
T
-
Y
E
G
V
E
G
A
S
----
A
S
I
S
I
A
T
A
V
I
S
A
I
E
G
I
P
V
D
Q
S
V
A
M
T
G
S
L
S
V
K
G
E
--------------------------------
V
L
P
V
G
G
V
T
Q
K
I
E
A
A
I
Q
A
G
L
K
K
V
I
I
P
K
D
N
I
D
D
V
L
-----
L
D
----
A
E
HEGK
I
----
E
V
I
P
V
S
R
I
N
E
V
L
E
H
V
L
E
D
-----
34
HHSearch
64.11
23%
-92
- C2 -
3WU4
-
?
A:
[12-188]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
Q
V
T
G
L
A
W
T
E
V
-
G
G
D
L
L
T
I
E
T
A
C
V
P
----------
G
----
K
-
G
K
L
-
T
Y
T
G
----
S
L
G
----
E
V
M
Q
E
S
I
Q
A
A
L
T
V
V
R
A
R
A
E
K
L
G
I
N
PD----
F
Y
E
K
R
D
---
I
H
V
H
-
V
P
E
G
---
A
-
T
P
-
K
D
G
P
A
----
A
G
I
A
M
C
T
A
L
V
S
C
L
T
G
N
P
V
R
A
D
V
A
M
T
G
E
I
T
L
R
G
Q
--------------------------------
V
L
P
I
G
G
L
K
E
K
L
L
A
A
H
R
G
G
I
K
T
V
L
I
P
F
E
N
K
R
D
L
E
E----
I
P
D
N
V
I
A
D
----
L
----
D
I
H
P
V
K
R
I
E
E
V
L
T
L
A
L
Q
------
30
Fugue
63.81
13%
-70
- C1 -
1TF7
4
KAIC_SYNE7
A:
[14-497]
---------------------------------------------------------------------------------
E
--
H
Q
A
I
A
K
M
R
T
M
I
E
G
F
D
D
I
S
H
G
G
L
P
I
G
R
S
T
L
V
S
G
T
S
G
T
G
K
T
L
F
S
I
Q
F
L
Y
N
G
I
----------------
I
------
E
F
D
E
P
G
V
F
V
------
T
F
E
E
--
T
--
P
Q
D
I
I
--------
K
N
--
A
R
S
F
G
W
D
----
L
-----
A
K
L
-----------------------
V
D
E
GK
L
F
I
L
D
ASPDP
E
G
Q
E
VVGG
F
D
L
S
---------
A
-----
L
I
E
-------
R
---
I
-------
N
---
Y
A
----
I
----
Q
---
K
--
Y
R
A
--------
R
------
R
V
S
I
D
S
V
-----
T
S
V
F
---
Q
---
Q
Y
D
A
S
S
V
V
R
R
E
L
F
R
L
V
A
R
L
K
Q
I
G
A
T
T
V
M
T
T
E
--
R
I
-----
E
E
Y
G
P
-----
I
A
R
Y
---
G
V
E
E
F
V
S
D
N
V
V
I
L
-------
R
N
V
L
E
G
E
R
R
R
R
T
L
E
I
L
K
L
R
G
T
S
H
M
K
-
G
E
Y
P
F
T
I
T
D
-
H
G
I
N
I
F
P
L
G
A
M
R
-
L
T
Q
R
S
S
N
V
R
V
S
SGV
V
R
L
D
E
M
C
G
GGFFKD
S
I
I
L
A
T
G
A
T
G
T
-
G
K
T
L
L
V
S
R
F
V
E
N
A
C
A
N
K
E
R
A
I
L
F
A
Y
E
-
E
S
-
R
A
Q
-
L
L
R
N
----
A
Y
S
----
W
G
----
M
D
F
E
E
M
E
R
Q
---
N
L
L
K
I
V
------
C
A
-
Y
P
E
---
S
A
G
L
-
E
D
-
H
---
L
-
Q
I
-
I
K
S
E
I
N
D
F
K
P
A
R
I
A
I
D
S
L
S
A
L
A
R
G
V
S
N
N
A
F
R
Q
F
V
I
G
V
T
G
Y
A
K
Q
E
E
I
T
G
L
F
T
N
T
S
DQFMGAHSITDSHISTITD
T
I
I
L
L
Q
Y
V
E
I
R
G
E
M
S
R
A
I
N
V
F
K
M
R
G
S
W
H
D
K
A
I
R
E
-----
F
M
----
I
S
----
D
----
K
G
P
D
I
K
D
S
F
R
N
F
E
R
I
I
S
G
S
P
T
R
I
2
PsiBlast_PDB
62.98
27%
-81
- C2 -
1Z0G
-
LONB_ARCFU
A:
[441-602]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
P
I
I
A
E
V
T
P
----------
S
M
-----
E
G
R
V
I
A
T
G
RL
Q
E
I
A
R
----
E
A
----
V
M
N
V
S
A
I
I
K
---
K
Y
T
G
R
D
------
I
S
-
N
M
D
---
V
H
I
Q
-
F
V
-
G
T
Y
E
G
-
V
E
-
G
D
S
A
S
----
I
S
I
A
T
A
V
--
I
S
A
I
E
G
I
P
V
D
Q
S
V
A
M
T
G
S
L
S
V
K
G
E
--------------------------------
V
L
P
V
G
G
V
T
Q
K
I
E
A
A
I
Q
A
G
L
K
K
V
I
I
P
K
D
N
I
D
D
V
L
-----
L
D
----
A
E
H
E
G
K
I
----
E
V
I
P
V
S
R
I
N
E
V
L
E
H
V
L
E
D
-----
25
Fugue
62.86
21%
-74
- C2 -
1RR9
-
LON_ECOLI
A:
[10-191]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
G
-------
Q
V
T
G
L
A
W
T
E
V
-
G
G
D
L
L
T
I
E
T
A
C
V
P
--------------
G
K
-
G
K
L
-
T
Y
T
G
SLG
E
V
M
Q
----
E
S
----
I
Q
A
A
L
T
V
V
R
---
A
R
A
E
K
L
GINPDF
Y
E
-
K
R
D
---
I
H
V
H
-
V
P
-
E
---
G
A
T
P
-
K
D
G
P
A
----
A
G
I
A
M
C
T
A
L
V
S
C
L
T
G
N
P
V
R
A
D
V
A
M
T
G
E
I
T
L
R
G
Q
--------------------------------
V
L
P
I
G
G
L
K
E
K
L
L
A
A
H
R
G
G
I
K
T
V
L
I
P
F
E
N
K
R
D
L
E
EIP
D
N
V
I
----
A
D
----
L
----
D
I
H
P
V
K
R
I
E
E
V
L
T
L
A
L
Q
N
EP---
1
PsiBlast_PDB
62.27
27%
-79
- C2 -
1Z0E
-
LONB_ARCFU
A:
[441-602]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
P
I
I
A
E
V
T
P
----------
S
M
-----
E
G
R
V
I
A
T
G
RL
Q
E
I
A
R
----
E
A
----
V
M
N
V
S
A
I
I
K
---
K
Y
T
G
R
D
------
I
S
-
N
M
D
---
V
H
I
Q
-
F
V
-
G
TYE
G
-
V
E
-
G
D
S
A
S
----
I
S
I
A
T
A
V
--
I
S
A
I
E
G
I
P
V
D
Q
S
V
A
M
T
G
S
L
S
V
K
G
E
--------------------------------
V
L
P
V
G
G
V
T
Q
K
I
E
A
A
I
Q
A
G
L
K
K
V
I
I
P
K
D
N
I
D
D
V
L
-----
L
D
----
A
E
H
E
G
K
I
----
E
V
I
P
V
S
R
I
N
E
V
L
E
H
V
L
E
D
-----
39
HHSearch
62.25
24%
-70
- C2 -
3K1J
2
?
A:
[400-578]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
I
G
-------
R
V
N
G
L
A
V
I
G
E
Q
S
G
I
V
L
P
I
E
A
V
V
A
P
----------
A
A
S
K
E
E
-
G
K
I
-
I
V
T
G
----
K
L
G
E
I
A
K
E
A
----
V
Q
N
V
S
A
I
I
K
---
R
Y
K
G
E
D
------
I
S
-
R
Y
D
---
I
H
V
Q
-
F
L
-
Q
---
T
Y
E
G
-
V
E
G
D
A
----
A
S
I
S
V
A
T
A
V
I
S
A
L
E
G
I
P
I
R
Q
D
V
A
M
T
G
S
L
S
V
R
G
E
--------------------------------
V
L
P
I
G
G
A
T
P
A
I
E
A
A
I
E
A
G
I
K
M
V
I
I
P
K
S
N
E
K
D
V
F
-----
L
S
K
D
K
A
E
K
----
I
----
Q
I
F
P
V
E
T
I
D
E
V
L
E
I
A
L
E
------
40
HHSearch
61.91
18%
-76
- C1 -
3LDA
3
RAD51_YEAST
A:
[98-396]
----------------
K
L
R
E
S
G
L
H
T
A
E
A
V
A
------
Y
A
P
R
----
K
D
L
L
E
I
K
G
I
S
E
A
K
A
D
K
L
L
N
E
A
A
R
L
V
--
P
M
G
F
V
T
A
A
D
F
H
M
R
R
S
E
L
I
C
L
T
T
G
S
K
N
L
D
T
L
L
G
G
G
V
E
T
G
S
I
T
E
L
F
G
E
F
R
T
G
K
S
Q
L
C
H
T
L
A
V
T
C
Q
----------------
I
PLDIGG
G
-
E
G
K
C
L
Y
I
------
D
T
E
G
--
T
FR
P
V
R
L
V
--------
S
I
--
A
Q
R
F
G
L
D
P
D
D
A
L
-----
N
N
V
-----------------------
A
----------------------
Y
A
R
A
---------
Y
-----
N
A
D
-------
H
---
Q
L
R
L
L
D
A
A
A
---
Q
M
----
M
----
S
---
E
--
S
R
F
--------
S
------
L
I
V
V
D
S
V
M
A
L
Y
R
--------GE-
L
S
A
R
Q
M
H
L
A
K
F
M
R
A
L
Q
R
L
A
D
Q
F
G
-
V
A
V
V
V
T
N
--
Q
V
----------------------
N
I
M
A
Y
S
S
T
T
R
L
G
F
-------
K
K
G
K
-
G
--
C
Q
R
L
C
K
V
V
D
S
P
C
L
P
-
E
--
A
E
C
V
F
A
I
Y
E
-
D
G
V
G
D
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.64
27%
-72
- C2 -
3K1J
2
?
A:
[407-577]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
-------
L
A
V
I
G
E
Q
S
G
----
I
V
L
P
I
E
A
V
V
A
P
----------
A
A
S
-
K
E
E
G
K
I
-
I
V
T
G
KLG
E
I
A
K
----
E
A
----
V
Q
N
V
S
A
I
I
K
---
R
Y
K
G
E
D
------
I
S
-
R
Y
D
I
H
V
Q
F
L
Q
-
T
Y
-
E
---
G
-
V
E
-
G
D
--
A
----
A
S
I
S
V
A
T
A
V
I
S
A
L
E
G
I
P
I
R
Q
D
V
A
M
T
G
S
L
S
V
R
G
E
--------------------------------
V
L
P
I
G
G
A
T
P
A
I
E
A
A
I
E
A
G
I
K
M
V
I
I
P
K
S
N
E
K
D
V
F
-----
L
S
----
K
D
K
A
E
K
I
----
Q
I
F
P
V
E
T
I
D
E
V
L
E
I
A
L
-------
44
HHSearch
61.63
21%
-88
- C1 -
1N0W
7
RAD51_HUMAN
A:
[2-242]
--------------------------------------------------------------------------------------
E
I
I
Q
I
T
T
G
S
K
E
L
D
K
L
L
Q
G
G
I
E
T
G
S
I
T
E
M
F
G
E
F
R
T
G
K
T
Q
I
C
H
T
L
A
V
T
C
Q
----------------
L
PIDRGG
G
-
E
G
K
A
M
Y
I
------
D
T
E
G
TF
R
--
P
E
R
L
L
--------
A
V
--
A
E
R
Y
G
L
S
----
G
S
D
V
L
-
D
N
V
-----------------------
A
----------------------
Y
A
R
A
---------
F
-----
N
T
D
H
Q
T
Q
L
L
Y
Q
---
A
-------
S
---
A
M
----
M
----
V
---
E
--
S
R
Y
--------
A
------
L
L
I
V
D
S
A
T
A
L
Y
R
--------E--
L
S
A
R
Q
M
H
L
A
R
F
L
R
M
L
L
R
L
A
D
E
F
G
-
V
A
V
V
I
T
N
-----------------------------
A
H
A
S
T
T
R
L
Y
L
-------
R
K
G
R
-
G
--
E
T
R
I
C
K
I
Y
D
S
P
C
L
P
-
E
A
--
E
A
M
F
A
I
N
A
-
D
G
V
G
D
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------