@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0886: (2016-03-19 )
MVTGWHRPTWIEIDRAAIRENIKNEQNKLPESVDLWAVVKANAYGHGIIEVARTAKEAGAKGFCVAILDEALALREAGFQDDFILVLGATRKEDANLAAKNHISLTVFREDWLENLTLEATLRIHLKVDSGMGRLGIRTTEEARRIEATSTNDHQLQLEGIYTHFATADQLETSYFEQQLAKFQTILTSLKNRPTYVHTANSAASLLQPQIGFDAIRFGISMYGLTPSTEIKTSLPFELKPALALYTEMVHVKELAPGDSVSYGATYTATEREWVATLPIGYADGLIRHYSGFHVLVGGELAPIIGRVCMDQTIIKLPREFQTGSKVTIIGKDHGNTITADDAAQYLDTINYEVTCLLNERIPRKYIH
Atome Classification :
(28 SA)
.........10----........20........30...---.....40........50......-..60........70........80........90..-......100........110.---.----..-----.--.----.------120---.------.------......130.......140-..-....---.150...--.-....160.......170--........180.......190---.---....---..200......---.210-......-...220.......-230.......240.......250.......260.......270.......280.......290.-.......300.......310.....---..--320-.........330.......340.......350.......360......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVTGWHRP
T
W
I
----
E
I
D
R
A
A
I
R
E
N
I
K
N
E
Q
NKLPESV
D
---
L
W
A
V
V
KANAYG
H
G
I
I
E
V
A
R
T
A
K
E
-AGAKG
F
C
V
A
I
L
D
E
A
L
A
L
R
EAGFQD
D
F
I
L
V
L
GATRKE-DANLAAKN-
H
I
S
L
T
V
F
R
E
D
W
L
---E----NL-----
T
--
L
----
E
------
A
T
----
L
------
R
------
I
H
L
K
VDSGMGRLGIRT
T
E
E
-A
R
-
R
I
EA---TST-ND
H
--
Q
-
L
Q
L
E
G
I
YTHFA
T
A
D
Q
L
---
E
T
S
Y
F
E
Q
Q
L
A
K
F
Q
T
I
L
T
S
LKN---R---P
T
Y
V
---
H
TAN
S
A
A
S
L
LQ---PQ---I
G
F
D
A
I
-
R
F
G
I
SMYGLTPST-
E
I
KTSLPFEL
K
P
A
L
A
L
Y
T
E
M
V
H
V
K
ELAPGDSVSYG
A
T
Y
TATE
R
E
W
V
A
TLP
I
G
Y
A
D
G
L
I
R
HYS-G-
F
H
V
L
VGG
E
L
A
P
I
I
G
R
V
C
M
D
Q
T
I
I
KL---
P
R
--
E
---FQTG
S
K
V
T
I
I
GKDHG
N
T
I
T
A
D
D
A
A
Q
Y
L
D
TIN
Y
E
V
T
C
L
LNERI
P
R
K
YIH
21
PsiBlast_CBE
96.12
53%
-102
- C2 -
1SFT
3
ALR_GEOSE
B:
[4-369]
----
F
H
R
D
T
W
A
----
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
H
---
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
-
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
-
I
L
V
L
G
A
S
R
P
A
-
D
A
A
L
A
A
Q
Q
-
R
I
A
L
T
V
F
R
S
D
W
L
---
E
----
E
A
-----
S
--
A
LYSG
P
------
F
P
----
I
------
H
------
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
E
E
E
-
T
K
-
R
I
V
A
---
L
I
E
-
R
H
P
--
H
-
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
---
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
P
L
V
---
H
C
A
N
S
A
A
S
L
R
F
---
P
D
---
R
T
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
-
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
--
P
---
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
-
22
PsiBlast_CBE
95.67
53%
-100
- C2 -
1BD0
2
ALR_GEOSE
B:
[4-369]
----
F
H
R
D
T
W
A
----
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
H
---
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
-
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
-
I
L
V
L
G
A
S
R
P
A
-
D
A
A
L
A
A
Q
Q
-
R
I
A
L
T
V
F
R
S
D
W
L
---
E
----
E
A
-----
S
--
A
LYSG
P
------
F
P
----
I
------
H
------
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
E
E
E
-
T
K
-
R
I
V
A
---
L
I
E
-
R
H
P
--
H
-
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
---
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
P
L
V
---
H
C
A
N
S
A
A
S
L
R
F
---
P
D
---
R
T
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
-
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
--
P
---
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
-
35
HHSearch
95.55
54%
-105
- C2 -
1BD0
2
ALR_GEOSE
A:
[4-370]
----
F
H
R
D
T
W
A
----
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
H
---
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
-
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
-
E
A
P
I
L
V
L
G
A
S
R
P
A
-
D
A
A
L
A
A
Q
Q
-
R
I
A
L
T
V
F
R
S
D
W
L
---
E
----
E
A
-----
S
--
A
----
L
Y
SGP--
F
P
----
I
------
H
------
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
-
E
E
E
T
K
-
R
I
V
A
---
L
I
E
-
R
H
P
--
H
-
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
---
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
P
L
V
---
H
C
A
N
S
A
A
S
L
R
F
---
P
D
---
R
T
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
-
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
--
P
---
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
R
1
PsiBlast_PDB
95.55
53%
-105
- C2 -
1SFT
3
ALR_GEOSE
A:
[4-369]
----
F
H
R
D
T
W
A
----
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
H
---
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
-
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
-
I
L
V
L
G
A
S
R
P
A
-
D
A
A
L
A
A
Q
Q
-
R
I
A
L
T
V
F
R
S
D
W
L
---
E
----
E
A
-----
S
--
A
L
Y
SG
P
------
F
P
----
I
------
H
------
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
E
E
E
-
T
K
-
R
I
V
A
---
L
I
E
-
R
H
P
--
H
-
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
---
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
P
L
V
---
H
C
A
N
S
A
A
S
L
R
F
---
P
D
---
R
T
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
-
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
--
P
---
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
-
2
PsiBlast_PDB
94.98
53%
-102
- C2 -
1BD0
2
ALR_GEOSE
A:
[4-369]
----
F
H
R
D
T
W
A
----
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
H
---
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
-
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
-
I
L
V
L
G
A
S
R
P
A
-
D
A
A
L
A
A
Q
Q
-
R
I
A
L
T
V
F
R
S
D
W
L
---
E
----
E
A
-----
S
--
A
L
Y
SG
P
------
F
P
----
I
------
H
------
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
E
E
E
-
T
K
-
R
I
V
A
---
L
I
E
-
R
H
P
--
H
-
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
---
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
P
L
V
---
H
C
A
N
S
A
A
S
L
R
F
---
P
D
---
R
T
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
-
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
--
P
---
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
-
7
PsiBlast_PDB
93.25
47%
-106
- C2 -
3HA1
3
?
A:
[6-374]
----
F
Y
R
D
T
W
V
----
E
V
D
L
D
A
I
Y
N
N
V
T
H
I
K
E
F
I
P
S
D
V
E
---
I
F
A
V
V
K
G
N
A
Y
G
H
D
Y
V
P
V
A
K
I
A
L
E
-
A
G
A
T
R
L
A
V
A
F
L
D
E
A
L
V
L
R
R
A
G
I
T
A
P
-
I
L
V
L
G
P
S
P
P
R
-
D
I
N
V
A
A
E
N
-
D
V
A
L
T
V
F
Q
K
E
W
V
D
--
E
----
A
I
-----
K
--
L
WDG-
S
------
S
T
----
M
------
K
------
Y
H
I
N
F
D
S
G
M
G
R
I
G
I
R
E
R
K
E
-
L
K
-
G
F
L
K
---
S
L
E
-
G
A
P
--
F
-
L
E
L
E
G
V
Y
T
H
F
A
T
A
D
E
V
---
E
T
S
Y
F
D
K
Q
Y
N
T
F
L
E
Q
L
S
W
L
K
E
FGV
D
---
P
K
F
V
---
H
T
A
N
S
A
A
T
L
R
F
---
Q
G
---
I
T
F
N
A
V
-
R
I
G
I
A
M
Y
G
L
S
P
S
V
-
E
I
R
P
F
L
P
F
K
L
E
P
A
L
S
L
H
T
K
V
A
H
I
K
Q
V
I
K
G
D
G
I
S
Y
N
V
T
Y
R
T
K
T
E
E
W
I
A
T
V
A
I
G
Y
A
D
G
W
L
R
R
L
Q
-
G
-
F
E
V
L
V
N
G
K
R
V
P
I
V
G
R
V
T
M
D
Q
F
M
I
H
L
---
P
C
--
E
---
V
P
L
G
T
K
V
T
L
I
G
R
Q
G
D
E
Y
I
S
A
T
E
V
A
E
Y
S
G
T
I
N
Y
E
I
I
T
T
I
S
F
R
V
P
R
I
F
I
-
23
PsiBlast_CBE
91.35
48%
-100
- C2 -
3E6E
2
?
C:
[2-370]
-
V
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
A
---
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
-
I
L
I
L
S
V
V
D
L
A
-
Y
V
P
L
L
I
Q
Y
-
D
L
S
V
T
V
A
T
Q
E
W
L
---
E
AALQ
Q
L
-----
T
--
P
----
E
------
S
N
TP--
L
------
R
------
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
E
-
T
K
-
Q
A
V
R
---
F
V
Q
-
S
H
K
--
E
-
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
---
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
R
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
---
P
D
---
V
P
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
-
N
-
K
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
--
25
PsiBlast_CBE
91.12
48%
-97
- C2 -
3E5P
6
?
C:
[1-370]
M
V
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
A
---
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
-
I
L
I
L
S
V
V
D
L
A
-
Y
V
P
L
L
I
Q
Y
-
D
L
S
V
T
V
A
T
Q
E
W
L
---
E
AALQ
Q
L
-----
T
--
P
----
E
------
S
N
TP--
L
------
R
------
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
E
-
T
K
-
Q
A
V
R
---
F
V
Q
-
S
H
K
--
E
-
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
---
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
R
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
---
P
D
---
V
P
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
-
N
-
K
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
--
26
PsiBlast_CBE
90.82
48%
-96
- C2 -
3E5P
2
?
B:
[1-370]
M
V
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
A
---
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
-
I
L
I
L
S
V
V
D
L
A
-
Y
V
P
L
L
I
Q
Y
-
D
L
S
V
T
V
A
T
Q
E
W
L
---
E
A
A
L
Q
Q
L
-----
T
--
P
----
E
------
S
N
TP--
L
------
R
------
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
E
-
T
K
-
Q
A
V
R
---
F
V
Q
-
S
H
K
--
E
-
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
---
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
R
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
---
P
D
---
V
P
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
-
N
-
K
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
--
5
PsiBlast_PDB
90.73
49%
-118
- C2 -
4ILS
-
ALR_GEOSE
A:
[4-369]
----
F
H
R
D
T
W
A
----
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
H
---
I
M
A
S
V
C
G
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
-
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
-
I
L
V
T
G
A
S
R
P
A
-
D
A
A
L
A
A
Q
Q
-
R
I
A
L
T
V
F
R
S
D
W
L
---
E
----
E
A
-----
S
--
A
L
Y
SG
P
------
F
P
----
I
------
H
------
F
H
L
Y
M
D
T
G
M
G
---
V
K
D
E
E
E
-
T
K
-
R
I
V
A
---
L
I
E
-
R
H
P
--
H
-
F
V
L
E
G
L
W
T
W
F
---------------
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
P
L
V
---
F
C
A
N
---
S
L
R
---------
R
T
F
N
M
V
-
Q
F
G
I
A
M
Y
G
L
A
-----------
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
K
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
L
M
D
M
C
M
I
R
L
---
P
G
--
P
---
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
K
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
F
-
3
PsiBlast_PDB
90.49
48%
-97
- C2 -
3E5P
5
?
A:
[2-370]
-
V
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
A
---
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
-
I
L
I
L
S
V
V
D
L
A
-
Y
V
P
L
L
I
Q
Y
-
D
L
S
V
T
V
A
T
Q
E
W
L
---
E
A
A
L
Q
Q
L
-----
T
--
P
----
E
------
S
N
TP--
L
------
R
------
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
E
-
T
K
-
Q
A
V
R
---
F
V
Q
-
S
H
K
--
E
-
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
---
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
R
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
---
P
D
---
V
P
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
-
N
-
K
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
--
34
HHSearch
90.32
48%
-98
- C2 -
3E5P
5
?
A:
[2-371]
-
V
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
A
---
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
-
Q
D
P
I
L
I
L
S
V
V
D
L
A
-
Y
V
P
L
L
I
Q
Y
-
D
L
S
V
T
V
A
T
Q
E
W
L
---
E
----
A
A
-----
L
--
Q
----
Q
L
TPESN
T
P
----
L
------
R
------
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
E
-
T
K
-
Q
A
V
R
---
F
V
Q
-
S
H
K
--
E
-
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
---
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
R
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
---
P
D
---
V
P
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
-
N
K
-
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
N
-
4
PsiBlast_PDB
90.14
48%
-92
- C2 -
3E6E
2
?
A:
[2-370]
-
V
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
A
---
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
-
I
L
I
L
S
V
V
D
L
A
-
Y
V
P
L
L
I
Q
Y
-
D
L
S
V
T
V
A
T
Q
E
W
L
---
E
A
A
L
Q
Q
L
-----
T
--
P
----
E
------
S
N
TP--
L
------
R
------
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
E
-
T
K
-
Q
A
V
R
---
F
V
Q
-
S
H
K
--
E
-
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
---
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
R
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
---
P
D
---
V
P
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
-
N
-
K
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
--
24
PsiBlast_CBE
89.93
48%
-94
- C2 -
3E6E
1
?
B:
[2-370]
-
V
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
A
---
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
A
A
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
-
I
L
I
L
S
V
V
D
L
A
-
Y
V
P
L
L
I
Q
Y
-
D
L
S
V
T
V
A
T
Q
E
W
L
---
E
AALQ
Q
L
-----
T
--
P
----
E
------
S
N
TP--
L
------
R
------
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
E
-
T
K
-
Q
A
V
R
---
F
V
Q
-
S
H
K
--
E
-
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
---
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
R
Y
V
---
H
V
S
N
S
A
T
A
L
W
H
---
P
D
---
V
P
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
S
G
-
N
-
K
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
--
E
---
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
--
8
PsiBlast_PDB
87.22
40%
-106
- C2 -
3OO2
3
ALR1_STAAC
A:
[5-371]
-
S
D
K
Y
Y
R
S
A
Y
M
----
N
V
D
L
N
A
V
A
S
N
F
K
V
F
S
T
L
H
P
N
K
T
----
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
E
-
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
-
I
L
V
L
G
V
L
P
A
K
-
D
I
D
K
A
I
Q
H
-
R
V
A
L
T
V
P
S
K
Q
W
L
---
K
E
A
I
K
N
I
-----
S
GE
Q
----
E
------
K
K
----
L
------
W
------
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
D
T
K
T
-
Y
Q
-
E
V
I
E
---
I
I
Q
-
Q
Y
E
--
Q
-
L
V
F
E
G
V
F
T
H
F
A
C
A
D
E
----
P
G
D
M
T
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
A
I
----
K
---
P
E
Y
I
---
H
C
Q
N
S
A
G
S
L
L
M
---
D
C
---
Q
F
C
N
A
I
-
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
-
Y
V
Q
Q
K
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
Q
A
G
E
S
V
S
Y
G
--
Y
T
A
T
D
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
-
S
F
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
--
Q
---
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
--
27
PsiBlast_CBE
84.78
40%
-103
- C2 -
3OO2
3
ALR1_STAAC
B:
[5-371]
-
S
D
K
Y
Y
R
S
A
Y
M
----
N
V
D
L
N
A
V
A
S
N
F
K
V
F
S
T
L
H
P
N
K
T
----
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
E
-
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
-
I
L
V
L
G
V
L
P
A
K
-
D
I
D
K
A
I
Q
H
-
R
V
A
L
T
V
P
S
K
Q
W
L
---
K
E
A
IK
N
I
-----
S
--------------
K
K
----
L
------
W
------
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
D
T
K
T
-
Y
Q
-
E
V
I
E
---
I
I
Q
-
Q
Y
E
--
Q
-
L
V
F
E
G
V
F
T
H
F
A
C
A
D
E
----
P
G
D
M
T
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
A
I
----
K
---
P
E
Y
I
---
H
C
Q
N
S
A
G
S
L
L
M
---
D
C
---
Q
F
C
N
A
I
-
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
-
Y
V
Q
Q
K
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
Q
A
-------------
D
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
-
S
F
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
--
Q
---
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
--
9
PsiBlast_PDB
84.63
40%
-109
- C2 -
4A3Q
10
ALR1_STAAM
A:
[2-368]
-
S
D
K
Y
Y
R
S
A
Y
M
----
N
V
D
L
N
A
V
A
S
N
F
K
V
F
S
T
L
H
P
N
K
T
----
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
E
-
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
-
I
L
V
L
G
V
L
P
A
K
-
D
I
D
K
A
I
Q
H
-
R
V
A
L
T
V
P
S
K
Q
W
L
---
K
E
A
I
K
N
I
-----
S
GE
Q
----
E
------
K
K
----
L
------
W
------
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
D
T
N
T
-
Y
Q
-
E
V
I
E
---
I
I
Q
-
Q
Y
E
--
Q
-
L
V
F
E
G
V
F
T
H
F
-----------
D
M
T
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
A
I
----
K
---
P
E
Y
I
---
H
C
Q
N
S
A
G
S
L
L
M
---
D
C
---
Q
F
C
N
A
I
-
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
-
Y
V
Q
Q
K
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
------------------
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
-
S
F
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
--
Q
---
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
--
28
PsiBlast_CBE
84.02
40%
-105
- C2 -
4A3Q
11
ALR1_STAAM
B:
[2-368]
-
S
D
K
Y
Y
R
S
A
Y
M
----
N
V
D
L
N
A
V
A
S
N
F
K
V
F
S
T
L
H
P
N
K
T
----
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
H
L
M
E
-
N
G
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
K
-
I
L
V
L
G
V
L
P
A
K
-
D
I
D
K
A
I
Q
H
-
R
V
A
L
T
V
P
S
K
Q
W
L
---
K
E
A
I
K
N
I
-----
S
GE
Q
----
E
------
K
K
----
L
------
W
------
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
D
T
N
T
-
Y
Q
-
E
V
I
E
---
I
I
Q
-
Q
Y
E
--
Q
-
L
V
F
E
G
V
F
T
H
F
-------------
T
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
A
I
----
K
---
P
E
Y
I
---
H
C
Q
N
S
A
G
S
L
L
M
---
D
C
---
Q
F
C
N
A
I
-
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
-
Y
V
Q
Q
K
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
----------------
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
-
S
F
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
--
Q
---
V
K
A
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
--
11
PsiBlast_PDB
81.46
34%
-108
- C2 -
4LUS
1
?
B:
[7-372]
-------
P
T
W
A
----
E
I
N
L
D
N
L
R
F
N
L
N
N
I
K
N
L
L
E
E
D
I
K
---
I
C
G
V
I
K
A
D
A
Y
G
H
G
A
V
E
V
A
K
L
L
E
K
-
E
K
V
D
Y
L
A
V
A
R
T
A
E
G
I
E
L
R
Q
N
G
I
T
L
P
-
I
L
N
L
G
Y
T
P
D
E
-
A
F
E
D
S
I
K
N
-
K
I
T
M
T
V
Y
S
L
E
T
A
---
Q
----
K
I
N
E
I
A
K
S
--
L
----
G
------
E
K
----
A
------
C
------
V
H
V
K
I
D
S
-----
G
F
Q
P
N
E
E
-
S
V
-
Q
-
E
I
---
I
E
L
-
N
K
L
--
E
Y
I
D
L
E
G
M
F
T
H
F
A
T
A
D
E
------
E
Y
T
Y
K
Q
A
N
N
Y
K
F
M
S
D
K
L
D
E
---
A
---
G
V
K
I
A
I
K
H
V
S
N
S
A
A
I
M
D
C
---
P
D
---
L
R
L
N
M
V
-
R
A
G
I
I
L
Y
G
H
Y
P
S
D
-
D
V
F
K
D
-
R
L
E
L
R
P
A
M
K
L
K
S
K
I
G
H
I
K
Q
V
E
P
G
V
G
I
S
Y
G
L
K
Y
T
T
T
G
K
E
T
I
A
T
V
P
I
G
Y
A
D
G
F
T
R
I
Q
K
-
N
-
P
K
V
L
I
K
G
E
V
F
D
V
V
G
R
I
C
M
D
Q
I
M
V
R
I
---
D
K
DI
D
---
I
K
V
G
D
E
V
I
L
F
G
E
G
E
---
V
T
A
E
R
I
A
K
D
L
G
T
I
N
Y
E
V
L
C
M
I
S
R
R
V
D
R
V
Y
M
E
13
PsiBlast_PDB
81.45
37%
-94
- C2 -
3HUR
3
?
A:
[3-374]
-
L
T
A
I
H
R
P
T
W
V
----
S
V
D
L
D
A
A
A
H
N
L
Q
-
E
I
R
E
W
T
K
A
K
K
---
V
Y
A
V
L
K
A
D
G
Y
G
L
G
A
I
P
L
A
K
A
F
Q
E
T
A
S
A
D
A
L
I
V
S
N
L
D
E
A
L
E
L
R
Q
A
D
L
T
L
P
-
I
W
V
L
G
A
W
D
Y
S
-
D
L
K
L
F
I
D
H
-
D
I
V
I
T
I
P
S
L
A
W
L
---
Q
----
N
L
-----
P
D-
F
----
E
------
G
T
----
L
------
K
------
V
S
L
A
I
D
T
G
M
T
R
I
G
F
D
K
A
D
E
-
I
S
-
A
A
K
K
---
I
I
D
-
K
N
P
--
Q
-
L
D
L
F
S
V
Y
T
H
F
A
T
A
D
E
A
G
E
K
S
K
A
Y
F
E
E
Q
L
R
R
W
Q
E
L
T
I
N
Q
G
F
---
D
---
P
S
L
F
---
S
M
A
N
S
A
T
C
I
W
H
HDD
P
R
---
I
S
F
A
A
I
-
R
P
G
Q
L
I
S
G
V
N
V
S
N
G
E
L
K
M
P
P
N
L
H
L
E
R
I
F
S
V
C
S
E
I
A
D
V
R
F
V
K
K
D
Q
S
L
S
Y
G
A
S
E
R
M
P
E
D
G
Y
V
A
T
L
P
F
G
Y
N
D
G
W
L
R
R
M
Q
-
K
-
S
S
V
I
I
N
G
K
R
M
P
I
I
G
R
I
T
M
D
Q
T
M
V
K
L
---
D
R
--
K
---
Y
P
I
G
T
R
V
T
L
I
G
K
D
G
G
E
Q
I
T
V
E
E
V
A
N
Y
S
H
T
I
V
D
E
I
Q
T
T
L
A
P
R
I
K
R
I
Y
--
10
PsiBlast_PDB
80.59
35%
-106
- C2 -
4LUT
2
?
A:
[7-372]
-------
P
T
W
A
----
E
I
N
L
D
N
L
R
F
N
L
N
N
I
K
N
L
L
E
E
D
I
K
---
I
C
G
V
I
K
A
D
A
Y
G
H
G
A
V
E
V
A
K
L
L
E
K
-
E
K
V
D
Y
L
A
V
A
R
T
A
E
G
I
E
L
R
Q
N
G
I
T
L
P
-
I
L
N
L
G
Y
T
P
D
E
-
A
F
E
D
S
I
K
N
-
K
I
T
M
T
V
Y
S
L
E
T
A
---
Q
----
K
I
N
E
I
A
K
S
--
L
----
G
------
E
K
----
A
------
C
------
V
H
V
K
I
D
-------
F
Q
P
N
E
E
-
S
V
-
Q
-
E
I
---
I
E
L
-
N
K
L
--
E
Y
I
D
L
E
G
M
F
T
H
F
A
T
A
D
E
V
---
S
K
E
Y
T
Y
K
Q
A
N
N
Y
K
F
M
S
D
K
L
D
E
---
A
---
G
V
K
I
A
I
K
H
V
S
N
S
A
A
I
M
D
C
---
P
D
---
L
R
L
N
M
V
-
R
A
G
I
I
L
Y
G
H
Y
P
S
D
-
D
V
F
K
D
-
R
L
E
L
R
P
A
M
K
L
K
S
K
I
G
H
I
K
Q
V
E
P
G
V
G
I
S
Y
G
L
K
Y
T
T
T
G
K
E
T
I
A
T
V
P
I
G
Y
A
D
G
F
T
R
I
Q
K
-
N
-
P
K
V
L
I
K
G
E
V
F
D
V
V
G
R
I
C
M
D
Q
I
M
V
R
I
---
D
K
D
I
D
---
I
K
V
G
D
E
V
I
L
F
G
E
G
E
---
V
T
A
E
R
I
A
K
D
L
G
T
I
N
Y
E
V
L
C
M
I
S
R
R
V
D
R
V
Y
M
E
37
HHSearch
80.30
33%
-97
- C2 -
3CO8
1
LYSR_OENOB
A:
[6-371]
----
I
H
R
S
T
R
I
----
E
F
S
K
S
S
L
A
Y
N
V
Q
Y
T
K
Q
V
S
G
-
A
K
T
---
L
W
L
A
V
K
S
N
A
Y
G
H
G
L
L
Q
V
S
K
I
A
R
E
-
C
G
V
D
G
L
A
V
S
V
L
D
E
G
I
A
I
R
Q
A
G
I
-
D
D
F
I
L
I
L
G
P
I
D
V
K
-
Y
A
P
I
A
S
K
Y
-
H
F
L
T
T
V
S
S
L
D
W
L
---
K
----
S
A
-----
D
--
K
----
I
LGK---
E
K
----
L
------
S
------
V
N
L
A
V
D
T
G
M
N
R
I
G
V
R
S
K
K
D
-
L
K
-
D
E
I
E
---
F
L
Q
E
H
S
D
--
H
-
F
S
Y
D
G
I
F
T
H
F
A
------------
F
Q
R
Q
K
N
R
W
Y
E
L
I
D
G
L
-
I
---
M
---
P
R
Y
V
---
H
V
M
N
S
G
A
A
M
Y
H
---
S
K
ELP
G
C
N
S
I
A
-
R
V
G
T
V
V
Y
G
V
E
P
S
E
-
G
V
-
L
G
P
I
D
K
L
K
P
V
F
E
L
K
S
A
L
T
F
V
K
K
I
P
A
G
E
G
I
S
Y
G
S
K
F
V
T
S
R
D
T
W
I
G
T
L
P
I
G
Y
G
D
G
W
L
A
E
Y
Q
-
D
-
F
Q
L
L
I
D
G
Q
K
C
R
Q
V
G
Q
I
A
M
D
Q
M
M
V
A
L
---
P
H
--
E
---
Y
P
I
G
T
E
V
T
L
I
G
K
S
G
K
Y
E
N
T
L
Y
D
L
H
K
H
S
G
V
P
P
W
K
I
T
V
A
F
S
D
R
L
K
R
M
V
V
-
12
PsiBlast_PDB
79.65
32%
-97
- C2 -
3CO8
1
LYSR_OENOB
A:
[7-371]
-----
H
R
S
T
R
I
----
E
F
S
K
S
S
L
A
Y
N
V
Q
Y
T
K
-
Q
V
S
G
A
K
T
---
L
W
L
A
V
K
S
N
A
Y
G
H
G
L
L
Q
V
S
K
I
A
R
E
-
C
G
V
D
G
L
A
V
S
V
L
D
E
G
I
A
I
R
Q
A
G
I
-
D
D
F
I
L
I
L
G
P
I
D
V
K
-
Y
A
P
I
A
S
K
Y
-
H
F
L
T
T
V
S
S
L
D
W
L
K
S
A
D
----
K
I
-----
L
--
G
----
K
------
E
K
----
L
------
S
------
V
N
L
A
V
D
T
G
M
N
R
I
G
V
R
S
K
K
D
-
L
K
D
E
I
E
F
---
L
Q
E
-
H
S
D
--
H
-
F
S
Y
D
G
I
F
T
H
F
A
------------
F
Q
R
Q
K
N
R
W
Y
E
L
I
D
G
L
I
M
-------
P
R
Y
V
---
H
V
M
N
S
G
A
A
M
Y
H
---
S
K
EL-
P
G
C
N
S
I
A
R
V
G
T
V
V
Y
G
V
E
P
S
E
-
G
V
L
G
P
I
D
-
K
L
K
P
V
F
E
L
K
S
A
L
T
F
V
K
K
I
P
A
G
E
G
I
S
Y
G
S
K
F
V
T
S
R
D
T
W
I
G
T
L
P
I
G
Y
G
D
G
W
L
A
E
Y
Q
-
D
-
F
Q
L
L
I
D
G
Q
K
C
R
Q
V
G
Q
I
A
M
D
Q
M
M
V
A
L
---
P
H
--
E
---
Y
P
I
G
T
E
V
T
L
I
G
K
S
G
K
Y
E
N
T
L
Y
D
L
H
K
H
S
G
V
P
P
W
K
I
T
V
A
F
S
D
R
L
K
R
M
V
V
-
40
HHSearch
78.16
32%
-100
- C2 -
1XFC
1
ALR_MYCTU
A:
[11-380]
-----------LAEA
M
V
D
L
G
A
I
E
H
N
V
R
V
L
R
E
H
A
G
-
H
A
Q
---
L
M
A
V
V
K
A
D
G
Y
G
H
G
A
T
R
V
A
Q
T
A
L
G
-
A
G
A
A
E
L
G
V
A
T
V
D
E
A
L
A
L
R
A
D
G
I
-
T
A
P
V
L
A
W
L
H
P
P
G
I
-
D
F
G
P
A
L
L
A
-
D
V
Q
V
A
V
S
S
L
R
Q
L
---
D
----
E
L
-----
L
--
H
----
A
V
R
R
T
G-
R
T
----
A
------
T
------
V
T
V
K
V
D
T
G
L
N
R
N
G
V
G
P
-
A
Q
-
F
P
-
A
M
L
T
A
L
R
Q
A
M
-
A
E
D
--
A
-
V
R
L
R
G
L
M
S
H
M
-----
P
---
D
D
S
I
N
D
V
Q
A
Q
R
F
T
A
F
L
A
Q
A
R
E
---
Q
GVR
F
E
V
A
---
H
L
S
N
S
S
A
T
M
A
R
---
P
D
---
L
T
F
D
L
V
-
R
P
G
I
A
V
Y
G
L
S
P
V
P
-
A
-
L
--
G
D
M
G
L
V
P
A
M
T
V
K
C
A
V
A
L
V
K
S
I
R
A
G
E
G
V
S
Y
G
H
T
W
I
A
P
R
D
T
N
L
A
L
L
P
I
G
Y
A
D
G
V
F
R
S
L
G
G
R
-
L
E
V
L
I
N
G
R
R
C
P
G
V
G
R
I
C
M
D
Q
F
M
V
D
L
---
G
P
--
G
PLD
V
A
E
G
D
E
A
I
L
F
G
P
G
I
R
G
E
P
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
V
T
S
P
R
G
R
I
T
R
T
Y
R
E
15
PsiBlast_PDB
75.57
32%
-98
- C2 -
1XFC
1
ALR_MYCTU
A:
[16-378]
----------------
V
D
L
G
A
I
E
H
N
V
R
V
L
R
E
H
A
G
H
A
-
Q
---
L
M
A
V
V
K
A
D
G
Y
G
H
G
A
T
R
V
A
Q
T
A
L
G
-
A
G
A
A
E
L
G
V
A
T
V
D
E
A
L
A
L
R
A
D
G
I
T
A
P
V
L
A
W
L
H
P
P
G
I
D
F
G
P
A
L
L
A
D
V
-
Q
V
A
V
S
S
L
R
Q
--
L
---
D
----
E
L
--------
L
----
H
------
A
V
----
R
------
R
T
GRTAT
V
T
V
K
V
D
T
G
L
N
R
N
G
V
G
P
A
Q
F
-
P
A
-
M
L
T
A
L
R
-
Q
A
M
-
A
E
D
--
A
-
V
R
L
R
G
L
M
S
H
M
-----
P
---
D
D
S
I
N
D
V
Q
A
Q
R
F
T
A
F
L
A
Q
A
R
E
Q
GV
R
---
F
E
V
A
---
H
L
S
N
S
S
A
T
M
A
R
---
P
D
---
L
T
F
D
L
V
-
R
P
G
I
A
V
Y
G
L
S
P
V
P
-
A
L
G
D
---
M
G
L
V
P
A
M
T
V
K
C
A
V
A
L
V
K
S
I
R
A
G
E
G
V
S
Y
G
H
T
W
I
A
P
R
D
T
N
L
A
L
L
P
I
G
Y
A
D
G
V
F
R
S
L
G
-
G
R
L
E
V
L
I
N
G
R
R
C
P
G
V
G
R
I
C
M
D
Q
F
M
V
D
L
GPG
P
L
--
D
---
V
A
E
G
D
E
A
I
L
F
G
P
G
I
R
G
E
P
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
V
T
S
P
R
G
R
I
T
R
T
Y
--
30
PsiBlast_CBE
74.93
32%
-95
- C2 -
1XFC
1
ALR_MYCTU
B:
[16-378]
----------------
V
D
L
G
A
I
E
H
N
V
R
V
L
R
E
H
A
G
H
A
-
Q
---
L
M
A
V
V
K
A
D
G
Y
G
H
G
A
T
R
V
A
Q
T
A
L
G
-
A
G
A
A
E
L
G
V
A
T
V
D
E
A
L
A
L
R
A
D
G
I
T
A
P
V
L
A
W
L
H
P
P
G
I
D
F
G
P
A
L
L
A
D
V
-
Q
V
A
V
S
S
L
R
Q
--
L
---
D
----
E
L
--------
L
----
H
------
A
V
----
R
------
R
T
GRTAT
V
T
V
K
V
D
T
G
L
N
R
N
G
V
G
P
A
Q
F
-
P
A
-
M
L
T
A
L
R
-
Q
A
M
-
A
E
D
--
A
-
V
R
L
R
G
L
M
S
H
M
V
Y
A
D
K
P
---
D
D
S
I
N
D
V
Q
A
Q
R
F
T
A
F
L
A
Q
A
R
E
Q
GV
R
---
F
E
V
A
---
H
L
S
N
S
S
A
T
M
A
R
---
P
D
---
L
T
F
D
L
V
-
R
P
G
I
A
V
Y
G
L
S
P
V
P
-
A
L
G
D
---
M
G
L
V
P
A
M
T
V
K
C
A
V
A
L
V
K
S
I
R
---------------
D
T
N
L
A
L
L
P
I
G
Y
A
D
G
V
F
R
S
L
G
-
G
R
L
E
V
L
I
N
G
R
R
C
P
G
V
G
R
I
C
M
D
Q
F
M
V
D
L
GPG
P
L
--
D
---
V
A
E
G
D
E
A
I
L
F
G
P
G
I
R
G
E
P
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
V
T
S
P
R
G
R
I
T
R
T
Y
--
58
Fugue
70.95
55%
-88
- C2 -
1BD0
1
ALR_GEOSE
A:
[12-244]
----------------
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
---D
T
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
-
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
-
A
P
I
L
V
L
G
A
S
R
P
A
-
D
A
A
L
A
A
Q
-
Q
R
I
A
L
T
V
F
R
S
D
W
L
---
E
----
E
A
-----
S
--
A
----
L
------
Y
------SGP
F
P
I
H
------
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
E
E
E
-
T
K
-
R
I
V
A
---
L
I
E
---
R
HP
H
-
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
---
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
----R--
P
P
L
V
---
H
C
A
N
S
A
A
S
L
R
F
---
P
D
---
R
T
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
-
G
I
K
P
L
L
P
Y
P
L
K
E
A
----------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
69.75
54%
-81
* C2 *
1BD0
1
ALR_GEOSE
A:
[12-244]
----------------
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
H
---
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
E
-
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
-
I
L
V
L
G
A
S
R
P
A
-
D
A
A
L
A
A
Q
Q
-
R
I
A
L
T
V
F
R
S
D
W
L
---
E
----
E
A
-----
S
--
A
----
L
------
Y
S
GP
F
P
I
------
H
------
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
E
E
E
-
T
K
-
R
I
V
A
---
L
I
E
-
R
H
P
--
H
-
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
---
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
P
L
V
---
H
C
A
N
S
A
A
S
L
R
F
---
P
D
---
R
T
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
-
G
I
K
P
L
L
P
Y
P
L
K
E
A
----------------------------------------------------------------------------------------------------------------------------------------