@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1078: (2016-03-21 )
MKVKKAVIPAAGLGTRFLPATKAMPKEILPIVDKPTIQFIVEEAVASGIEDILIVTGKGKRAIEDHFDSVPELENNLREKNKLDLLHLVEETTNINLHFIRQSKPKGLGDAILQAKGFIGNEPFVVMLGDDIVQSKTPCAKQLIDQYEKTHSSVIGVQNVPREETYRYGIIDPDKEVSDRLYNVTGFVEKPNVEDAPSNLAILGRYLLTPEIFKYLETQEAGSGGEIQLTDAINRLNEIQPVFAYDFEGERFDVGDKFGFIETTLKFALKHPEIKDDVRDLIIRLGDELK
Atome Classification :
(21 SA)
.........10........20........30........40........50.-.......60........70........80---.-.......90.-.-.-.-....100.......110.......120.....--....130.....--..----140.......150......-.160.......170......-.180........190.......200.......210.......220.......230....-..-.240......--.250---.......260.......270----......---.280....----...290----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKVKKAVIPAAGLGTRFLPATKAM
P
K
E
I
LPIVDK
P
T
I
Q
F
I
V
E
E
A
V
ASGI
E
D
I
-
L
I
V
TGKGK
R
A
I
E
D
H
FDS
V
P
E
L
E
N
N
L
REK
N
---
K
-
L
D
L
L
H
L
V
E
ET-T-N-
I
-
N
L
H
F
I
RQSKPK
G
L
G
D
A
I
L
Q
AKGFIG--NE
P
F
V
--
V
M
LGDDIVQSKT--
P
C
----
A
K
Q
L
I
D
Q
Y
E
K
T
H
S
SVIGVQ-NVPR
E
E
T
Y
R
YGIIDP
D
K
E
V
S
-
D
R
-
L
YNVTGFVEKPNVEDAPS
N
L
A
I
L
G
R
Y
LL
T
P
E
I
F
K
Y
L
E
T
QEAGSGG
E
I
Q
L
T
D
A
I
N
R
L
-NE-IQ
P
V
F
A
YDFE--GERF---DVGDKF
G
F
I
E
T
T
L
K
F
A
LKHP----
E
I
K
D
D
V
---
R
D
L
I
I
RLG----DELK------------------------
22
PsiBlast_CBE
92.11
48%
-91
- C1 -
2UX8
1
?
G:
[14-294]
--
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
---
K
S
L
D
V
L
D
G
T
R
L
K
-
P
-
G
---
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
--
V
L
L
P
D
D
F
M
F
G
Q
P
--
G
C
----
L
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
-
E
V
P
D
D
Q
T
H
R
Y
G
I
I
T
P
G
T
Q
-
D
-
G
V
-
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
K
G
A
G
G
E
I
Q
L
T
D
A
M
Q
R
M
-
I
G
-
D
Q
P
F
H
G
V
T
F
Q
--
G
T
R
Y
---
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
----
D
L
E
P
A
V
---
R
A
F
A
V
K
----------------------------------
24
PsiBlast_CBE
90.13
48%
-91
- C1 -
2UX8
1
?
E:
[14-294]
--
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
---
K
S
L
D
V
L
D
G
T
R
L
K
-
P
-
G
---
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
--
V
L
L
P
D
D
F
M
F
G
Q
P
--
G
C
----
L
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
-
E
V
P
D
D
Q
T
H
R
Y
G
I
I
T
P
G
T
Q
-
D
-
G
V
-
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
--------
Q
L
T
D
A
M
Q
R
M
-
I
G
-
D
Q
P
F
H
G
V
T
F
Q
--
G
T
R
Y
---
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
----
D
L
E
P
A
V
---
R
A
F
A
V
K
----------------------------------
26
PsiBlast_CBE
88.16
48%
-90
- C1 -
2UX8
1
?
C:
[14-294]
--
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
---
K
S
L
D
V
L
D
G
T
R
L
K
-
P
-
G
---
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
--
V
L
L
P
D
D
F
M
F
G
Q
P
--
G
C
----
L
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
-
E
V
P
D
D
Q
T
H
R
Y
G
I
I
T
P
G
T
Q
-
D
-
G
V
-
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
-------
Q
L
T
D
A
M
Q
R
M
-
I
G
-
D
Q
P
F
H
G
V
T
F
Q
--
G
T
R
Y
---
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
----
D
L
E
P
A
V
---
R
A
F
A
V
K
----------------------------------
27
PsiBlast_CBE
87.98
48%
-91
- C1 -
2UX8
1
?
B:
[14-294]
--
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
---
K
S
L
D
V
L
D
G
T
R
L
K
-
P
-
G
---
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
--
V
L
L
P
D
D
F
M
F
G
Q
P
--
G
C
----
L
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
-
E
V
P
D
D
Q
T
H
R
Y
G
I
I
T
P
G
T
Q
-
D
-
G
V
-
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
--------
L
T
D
A
M
Q
R
M
-
I
G
-
D
Q
P
F
H
G
V
T
F
Q
--
G
T
R
Y
---
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
----
D
L
E
P
A
V
---
R
A
F
A
V
K
----------------------------------
25
PsiBlast_CBE
87.81
48%
-92
- C1 -
2UX8
1
?
D:
[14-294]
--
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
---
K
S
L
D
V
L
D
G
T
R
L
K
-
P
-
G
---
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
--
V
L
L
P
D
D
F
M
F
G
Q
P
--
G
C
----
L
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
-
E
V
P
D
D
Q
T
H
R
Y
G
I
I
T
P
G
T
Q
-
D
-
G
V
-
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
-------
Q
L
T
D
A
M
Q
R
M
-
I
G
-
D
Q
P
F
H
G
V
T
F
Q
--
G
T
R
Y
---
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
----
D
L
E
P
A
V
---
R
A
F
A
V
K
----------------------------------
23
PsiBlast_CBE
87.62
48%
-89
- C1 -
2UX8
1
?
F:
[14-294]
--
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
---
K
S
L
D
V
L
D
G
T
R
L
K
-
P
-
G
---
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
--
V
L
L
P
D
D
F
M
F
G
Q
P
--
G
C
----
L
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
-
E
V
P
D
D
Q
T
H
R
Y
G
I
I
T
P
G
T
Q
-
D
-
G
V
-
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
K
------
Q
L
T
D
A
M
Q
R
M
-
I
G
-
D
Q
P
F
H
G
V
T
F
Q
--
G
T
R
Y
---
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
----
D
L
E
P
A
V
---
R
A
F
A
V
K
----------------------------------
21
PsiBlast_CBE
87.62
48%
-106
- C1 -
2UX8
1
?
H:
[14-294]
--
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
-
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
---
K
S
L
D
V
L
D
G
T
R
L
K
-
P
-
G
---
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
F
A
--
V
L
L
P
D
D
F
M
F
G
Q
P
--
G
C
----
L
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
-------------------------
L
T
E
V
K
G
L
--------------
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
---------
Q
L
T
D
A
M
Q
R
M
-
I
G
-
D
Q
P
F
H
G
V
T
F
Q
--
G
T
R
Y
---
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
----
D
L
E
P
A
V
---
R
A
F
A
V
K
----------------------------------
1
PsiBlast_PDB
85.06
44%
-97
- C1 -
3JUJ
-
?
A:
[2-265]
--
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
-
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
E
I
E
H
Q
I
Q
G
T
N
---
K
-
E
N
A
L
K
S
I
R
N
I
-
I
E
K
-
C
-
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
F
A
--
V
I
L
A
D
D
L
C
I
S
H
D
HP
S
V
----
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
-
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
G
E
-
W
L
E
-
E
G
-
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
-
A
K
-
R
K
R
I
I
A
Y
Q
F
K
--
G
K
R
Y
---
D
C
G
S
V
E
G
Y
I
E
A
S
-------------------------------------------------------------
31
PsiBlast_CBE
83.93
39%
-96
- C1 -
2PA4
2
?
D:
[12-299]
--
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
-
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
-------
D
Q
V
E
I
I
R
R
A
-
A
-
D
L
I
-
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
VA
V
M
L
P
D
D
L
V
L
P
-
T
--
G
V
----
M
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
-
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
K
-
D
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
-
G
H
P
V
H
I
V
I
H
Q
--
G
K
R
H
---
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
VYGA
Q
L
K
D
A
I
---
K
Q
I
L
------------------------------------
32
PsiBlast_CBE
83.29
39%
-90
- C1 -
2PA4
2
?
C:
[12-299]
--
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
-
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
G
---
K
-
T
D
Q
V
E
I
I
R
R
A
-
A
-
D
L
I
-
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
M
L
P
D
D
L
V
L
P
-
T
--
G
V
----
M
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
-
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
K
-
D
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
-
G
H
P
V
H
I
V
I
H
Q
--
G
K
R
H
---
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
I
---
K
Q
I
L
------------------------------------
3
PsiBlast_PDB
83.21
39%
-92
- C1 -
2PA4
2
?
A:
[12-299]
--
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
-
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
G
---
K
-
T
D
Q
V
E
I
I
R
R
A
-
A
-
D
L
I
-
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
M
L
P
D
D
L
V
L
P
-
T
--
G
V
----
M
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
-
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
K
-
D
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
-
G
H
P
V
H
I
V
I
H
Q
--
G
K
R
H
---
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
VY
G
A
Q
L
K
D
A
I
---
K
Q
I
L
------------------------------------
43
HHSearch
83.14
38%
-89
- C1 -
2PA4
2
?
A:
[12-302]
--
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
-
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
G
K
T
D
Q
-
V
E
I
I
R
---
R
A
-
A
-
D
-
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
DD
E
D
V
V
A
--
V
M
L
P
D
D
L
V
L
P
T
---
G
V
----
M
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
-
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
K
D
S
D
-
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
-
I
D
E
G
H
P
V
H
I
V
I
H
Q
--
G
K
R
H
---
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
----
V
Y
G
A
Q
L
---
K
D
A
I
K
Q
I
L
----
A
E
H
-------------------------
33
PsiBlast_CBE
82.54
39%
-87
- C1 -
2PA4
2
?
B:
[12-299]
--
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
-
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
G
---
K
-
T
D
Q
V
E
I
I
R
R
A
-
A
-
D
L
I
-
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
M
L
P
D
D
L
V
L
P
-
T
--
G
V
----
M
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
-
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
K
-
D
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
-
G
H
P
V
H
I
V
I
H
Q
--
G
K
R
H
---
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
VY
G
A
Q
L
K
D
A
I
---
K
Q
I
L
------------------------------------
28
PsiBlast_CBE
82.42
44%
-95
- C1 -
3JUK
4
?
D:
[2-265]
--
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
-
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
--------
T
N
---
K
-
E
N
A
L
K
S
I
R
N
I
-
I
E
K
-
C
-
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
F
A
--
V
I
L
A
D
D
L
C
I
S
H
D
HP
S
V
----
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
-
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
G
E
-
W
L
E
-
E
G
-
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
-
A
K
-
R
K
R
I
I
A
Y
Q
F
K
--
G
K
R
Y
---
D
C
G
S
V
E
G
Y
I
E
A
S
-------------------------------------------------------------
2
PsiBlast_PDB
80.96
44%
-98
- C1 -
3JUK
4
?
A:
[2-265]
--
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
-
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
--------
T
N
---
K
-
E
N
A
L
K
S
I
R
N
I
-
I
E
K
-
C
-
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
F
A
--
V
I
L
A
D
D
L
C
I
S
H
D
HP
S
V
----
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
-
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
G
E
-
W
L
E
-
E
G
-
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
-
A
K
-
R
K
R
I
I
A
Y
Q
F
K
--
G
K
R
Y
---
D
C
G
S
V
E
G
Y
I
E
A
S
-------------------------------------------------------------
29
PsiBlast_CBE
80.58
44%
-97
- C1 -
3JUK
4
?
C:
[2-265]
--
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
-
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
---------
N
---
K
-
E
N
A
L
K
S
I
R
N
I
-
I
E
K
-
C
-
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
F
A
--
V
I
L
A
D
D
L
C
I
S
H
D
HP
S
V
----
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
-
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
G
E
-
W
L
E
-
E
G
-
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
-
A
K
-
R
K
R
I
I
A
Y
Q
F
K
--
G
K
R
Y
---
D
C
G
S
V
E
G
Y
I
E
A
S
-------------------------------------------------------------
30
PsiBlast_CBE
79.73
44%
-96
- C1 -
3JUK
4
?
B:
[2-265]
--
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
-
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
---------
N
---
K
-
E
N
A
L
K
S
I
R
N
I
-
I
E
K
-
C
-
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
F
A
--
V
I
L
A
D
D
L
C
I
S
H
D
HP
S
V
----
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
-
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
G
E
-
W
L
E
-
E
G
-
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
-
A
K
-
R
K
R
I
I
A
Y
Q
F
K
--
G
K
R
Y
---
D
C
G
S
V
E
G
Y
I
E
A
S
-------------------------------------------------------------
45
HHSearch
79.50
44%
-97
- C1 -
3JUK
5
?
A:
[1-273]
-
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
-
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
--------
T
N
---
K
-
E
N
A
L
K
S
I
R
N
I
I
E
-
K
-
C
-
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
F
A
--
V
I
L
A
D
D
L
C
I
S
----
H
D
HPS
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
-
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
G
E
W
L
E
--
E
G
-
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
-
A
K
-
R
K
R
I
I
A
Y
Q
F
K
--
G
K
R
Y
---
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
Y
K
K
R
L
-----------------------------------------------------
64
Fugue
61.92
25%
-78
- C1 -
1FXO
2
?
A:
[2-293]
--
K
R
K
G
I
I
L
A
G
G
S
G
T
R
L
H
P
A
T
L
A
I
S
K
Q
L
L
P
V
Y
D
K
P
M
I
Y
Y
P
L
S
T
L
M
L
A
G
I
R
E
I
-
L
I
I
S
T
P
---------
Q
D
T
P
R
F
Q
Q
L
L
G
D
G
S
---
N
-
W
------------
G
-
L
-
D
L
Q
Y
A
V
Q
P
S
P
D
G
L
A
Q
A
F
L
I
G
E
S
F
I
G
--
N
D
L
S
A
--
L
V
L
G
D
N
L
Y
Y
G
H
---
D
F
----
H
E
L
L
G
S
A
S
Q
R
Q
T
G
A
S
V
F
A
Y
-
H
V
L
D
P
E
R
Y
--
G
V
V
E
F
D
Q
G
-------
G
K
A
I
S
L
E
E
K
P
--
L
E
P
K
S
N
Y
A
V
T
G
L
Y
F
Y
D
Q
Q
V
V
D
I
A
R
D
L
K
P
S
P
R
G
E
L
E
I
T
D
V
N
R
A
Y
-
L
E
-
R
G
Q
L
S
V
E
I
M
G
RG
Y
A
W
L
---
D
T
G
T
H
D
S
L
L
E
A
G
Q
F
I
A
T
L
E
N
----
R
Q
G
L
K
V
AC
P
E
E
I
A
Y
R
Q
K
WID
A
A
Q
L
E
K
L
A
A
P
L
AKN
G
Y
G
Q
Y
L
K
R
L
L
T
ETVY
11
PsiBlast_PDB
59.52
26%
-73
- C1 -
1MP4
1
RMLA_SALTY
A:
[1-237]
M
K
T
R
K
G
I
I
L
A
G
G
S
G
T
R
L
Y
P
V
T
M
A
V
S
Q
Q
L
L
P
I
Y
D
K
P
M
I
Y
Y
P
L
S
T
L
M
L
A
G
I
R
D
I
-
L
I
I
S
T
P
---------
Q
D
T
P
R
F
Q
Q
L
L
G
D
G
S
---
Q
-
W
G
L
--------------
N
L
Q
Y
K
V
Q
P
S
P
D
G
L
A
Q
A
F
I
I
G
E
E
F
I
G
--
H
D
D
C
A
--
L
V
L
G
D
N
I
F
Y
G
H
D
---
L
----
P
K
L
M
E
A
A
V
N
K
E
S
G
A
T
V
F
A
Y
-
H
V
N
D
P
E
--
R
Y
G
V
V
E
F
D
Q
A
G
T
-------
A
V
S
L
E
E
K
P
--
L
Q
P
K
S
N
Y
A
V
T
G
L
Y
F
Y
D
N
S
V
V
E
M
A
K
N
L
K
P
S
A
R
G
E
L
E
I
T
D
-
I
N
R
I
-
Y
M
-
E
Q
G
R
L
S
V
A
M
M
--
G
R
G
Y
A
H
L
D
T
G
T
H
Q
S
L
I
E
A
S
-------------------------------------------------------------
5
PsiBlast_PDB
53.89
31%
-80
- C1 -
2GGQ
2
?
A:
[2-223]
----
K
A
F
I
L
A
A
G
S
G
E
R
L
E
P
I
T
H
T
R
P
K
A
F
V
P
I
L
S
K
P
L
I
E
Y
Q
I
E
Y
L
R
K
C
G
I
R
D
I
T
V
I
V
S
S
K
N
K
E
Y
F
E
----------------
K
---
K
-
L
K
E
I
S
I
V
T
Q
K
-
D
-
D
-
I
-----------
K
G
T
G
A
A
I
L
S
A
K
F
-----
N
D
E
A
L
--
I
I
Y
G
D
L
F
F
S
N
E
----------
K
E
I
C
N
I
I
T
L
K
E
N
A
I
I
G
V
K
V
S
N
P
K
D
----
Y
G
V
L
-----
V
L
-
D
N
-
Q
N
N
L
S
K
I
I
E
K
P
--
E
I
P
P
S
N
L
I
N
A
G
I
Y
K
L
N
S
D
I
F
T
Y
L
D
K
I
S
I
S
E
R
G
E
L
E
L
T
D
A
I
N
L
M
-
A
K
-
D
H
R
V
K
V
I
E
Y
E
--
G
Y
W
M
---
D
I
G
K
P
W
N
I
I
D
V
N
-
K
W
A
L
--------------------------------------------------------