@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1142: (2016-03-22 )
LSQMSILEKIKDAGVVGCGGAGFPTHAKFSGEVEYLIINAAECEPLLKTDHFVMRNHAVETIKAIEMVKSQVGAEFAVIATKRYYTEEIAALRSAITELDASVTIHEMDNVYPTGDEQVMVFEVTGRVVPPSGIPLMVGCIVSNVSTMWNVFHAIQDDAPVVRKQLTVTGAVGEPKLLDVPVGTPFEVCLAAAGGTNLDEYLFLDGGPMMGKLNDQSTIADKVVTKTTSGLIVAEDTGYLHKLHYQTVEQIFNETKSACIQCSLCSDLCPRQQLGHDIHPHKVMRHFAVAEDITDIKPDPIWEEAMICCECGICEVIACPMGLSPRQVNIHVKKELLKQGVRYQTDKKEFTPDPMREYKSIAPKNILIKMGLQQYADVHLEKMHYLEVDEVFIPTKMHIGAPSIPVVSEGDIVKKGDLIAKIPDTALGANIHASIDGQIIRITEEQVHIKKVMS
Atome Classification :
(20 SA)
-----------------------------------------.........10-.--.......20-..----------......------30-----.------.--....--...40........50-....-------..--...60------------.........---------70-------..-....-...80.-.....------..90........---------------100---------------.......110....-...120.--..----.-----...130.---.--------------....-----.--------140......-.150---------...---....-.160----------.----------.----.....170.....-.-..180-------------....-..-...190-...---....200--------..-----------...--..210.-------.---.....220....-------.----------....230.......240.......-250.......260.-----......------270.....--..280.......290..----......300----....-----.....310-.......320.......330.......340--........---------.350.......360...--....370.......-380...-----------....390.......-400-.........410........420.......430.-----.......----440.-------------------......450..-------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------L
S
Q
M
S
I
L
E
K
I
K
-D--AGVVGCGGA-GF----------PTHAKF------S------G------E--
V
E
Y
L
--
I
I
N
A
AECEPLLKTD--
H
F
V
M
-------
R
N
--
H
A
V
E
-------------
T
I
K
A
I
E
M
V
K
---------
S
--------QV-GA
E
F
-
A
V
I
A
TK-
R
Y
Y
T
E
------
E
I
A
A
L
R
S
A
I
T
E
L---------------DA
S
---------------
V
T
I
H
EMDNVYPTGD-
E
Q
V
M
V
F
E
--VT----G-----RVVPPSG---I--------------
P
L
M
V
-----
G
--------
C
I
VS
N
V
S
T
M
-
W
N
V
----------
F
H
A
---IQDD-A
P
V
V
----------
R
----------
K
----
Q
L
T
V
TGA-VGEP
K
-
L
-
L
DV---------------PVG
T
-
P
F
-
E
V
C
L
AA-AGG---TNL
D
E
Y
L
--------
F
L-----------DGG--PMMGKL-------N---D
Q
S
T
I
A
--
D
K
V
V
-------T----------KTTS
G
L
I
V
AEDTG
Y
L
H
K
L
H
Y
Q
T
V
E
-
Q
I
F
N
E
T
K
S
A
C
I
Q
C
S
-----
L
C
S
DLC------
P
R
Q
Q
LGHD--I
H
P
H
K
V
M
R
H
F
A
V
A
E
-
D
I
----TDIKPDP------
I
W
E
E
-----
A
M
I
C
CECG-
I
C
E
V
I
ACPMGLSP
R
Q
V
N
I
H
V
K
K
E
L
L
KQG----VRYQTDKK---------EFT
P
D
P
M
R
E
Y
K
SIAPK
N
--
I
L
I
K
M
G
L
Q
Q
Y
A
D
V
H
-
L
E
K
M
H
Y
-----------
L
E
VD
E
V
FIPTKMHI-G---APSIPVVSEG
D
-
I
V
KKG
D
L
I
A
KIPDTALG
A
N
-
I
H
-----
A
SID
G
Q
I
----
I
R
I
T-------------------EE
Q
V
H
I
K
K
VMS-------------------
21
Fugue
99.60
21%
0
- C- -
2FUG
-
?
?:
[7-6]
S
G
L
D
P
RFERTLYAHVGKEGSWT
L
D
Y
Y
L
R
H
GGY
E
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A
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R
V
L
K
E
K
T
P
D
E
V
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E
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V
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-
R
--
S
G
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R
G
R
G
G
A
-
G
F
----------
P
T
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L
K
W
S
F
MPKD
D
------
G
------
K
--
Q
H
Y
L
--
I
C
N
A
D
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F
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D
--
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-------
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--
V
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-------------
L
I
E
G
M
I
L
A
G
---------
Y
--------
A
I
-
R
A
T
V
-
G
Y
I
Y
V
R
-
G
E
Y
R
R
------
A
A
D
R
L
E
Q
A
I
K
E
A
---------------
R
A
R
GYLGKNLFGTD
F
S
F
D
L
H
V
H
R
G
A
G
A
Y
I
C
G
E
-
E
T
A
L
M
N
S
--
L
E
----
G
-----
L
R
A
N
P
R
L
---
K
--------------
P
P
F
P
-----
A
QSGLWGKP
T
T
I
N
N
V
E
T
L
-
A
S
V
----------
V
P
I
---
M
E
R
G
-
A
D
W
F
----------
A
Q
M
GTEQSKGM
K
----
L
Y
Q
I
S
G
P
-
V
K
R
P
G
-
V
-
Y
E
L
---------------
P
M
G
T
-
T
F
-
R
E
L
I
Y
E
-
W
A
G
---
G
P
L
E
P
I
Q
--------
A
I
I
P
GGSS
T
P
P
L
P
F
T
E
--
E
V
L
D
T
P
-------
M
---
S
Y
E
H
L
Q
--
A
K
G
S
-------
M
----------
L
G
T
G
G
V
I
L
I
P
E
R
V
S
M
V
D
A
M
W
N
L
T
R
-
F
Y
A
H
E
S
------------------------------------------------------------------------------------
C
G
-
K
C
---------------------------------------------------
T
P
C
R
E
G
V
A
G
F
M
V
N
--
L
F
A
K
I
G
T
G
Q
G
E
E
K
D
-
V
E
N
L
E
A
-----------
L
-
L
P
L
I
E
G
R
S
F
C
P
L
-
A
---
D
A
A
V
W
P
V
K
G
S
L
-
R
H
F
K
D
Q
Y
L
A
L
A
R
E
------------------------------------------------
K
R
P
V
P
R
P
S
L
W
R
-------------------
31
HHSearch
95.63
22%
0
- C- -
3I9V
-
1:
[48--12]
-----------------------------------------
K
T
P
D
E
V
I
E
E
V
K
-
R
--
S
G
L
R
G
R
G
G
A
-
G
F
----------
P
T
G
L
K
W
------
S
------
F
MPKDDG
K
--
Q
H
Y
L
--
I
C
N
A
D
E
S
E
P
G
S
F
K
D
--
R
Y
I
L
-------
E
D
--
V
P
H
L
-------------
L
I
E
G
M
I
L
A
G
---------
Y
--------
A
I
-
R
A
T
V
-
G
Y
I
Y
V
R
-
G
E
Y
R
R
------
A
A
D
R
L
E
Q
A
I
K
E
A
RARGYLGKNLFGTDF
S
F
D
---------------
L
H
V
H
R
G
A
G
A
Y
I
C
G
E
-
E
T
A
L
M
N
S
--
L
E
----
G
-----
L
R
A
N
P
R
L
KPP
F
--------------
P
A
Q
S
GLWGK
P
--------
T
T
I
N
N
V
E
T
L
-
A
S
V
----------
V
P
I
---
M
E
R
G
-
A
D
W
F
AQMGTEQSKG
M
----------
K
----
L
Y
Q
I
S
G
P
-
V
K
R
P
G
-
V
-
Y
E
L
---------------
P
M
G
T
-
T
F
-
R
E
L
I
Y
E
W
A
G
G
---
P
L
E
P
I
Q
A
--------
I
I
-----------
P
G
G
--
S
S
T
P
P
L
-------
P
FTE
E
V
L
-----
D
T
P
M
-------
S
YEHLQAKGSM
L
G
T
G
G
V
I
L
I
P
E
R
V
S
M
V
D
A
M
W
N
L
T
R
----
F
Y
A
H
E
S
C
G
K
C
T
-----
P
C
R
E
G
V
------
A
G
F
--------
M
V
N
L
F
A
K
I
-
G
T
G
Q
G
E
E
----
K
D
---
V
E
------
N
L
E
A
-----
L
L
P
L
I
E
G
R
S
F
C
P
-
L
A
D
A
A
V
W
P
V
K
G
S
L
R
H
F
K
D
Q
Y
L
A
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
74.42
18%
-49
- C3 -
1SQ9
2
SKI8_YEAST
A:
[3-395]
---------------------------------------K
V
F
I
A
T
A
N
A
G
K
A
H
-
D
--
A
D
I
F
S
V
S
A
C
N
S
F
----------
T
V
S
C
S
G
------
D
------
G
------
Y
--
L
K
V
W
D
N
K
L
L
D
N
E
N
P
K
D
K
S
Y
S
--
H
F
V
H
-------
K
S
GL
H
H
V
D
-------------
V
L
Q
A
I
E
---------------------
R
D
-
A
F
E
L
-
C
L
V
A
T
T
-
S
F
-
S
G
------
D
L
L
F
Y
R
I
T
R
E
D
E
---------------
T
K
K
---------------
V
I
F
E
K
L
D
L
L
----
D
-
S
D
M
K
K
H
S
--
F
W
----
A
-----
L
K
W
G
A
S
N
---
S
--------------
H
R
L
V
-----
A
--------
T
D
V
K
G
T
T
Y
I
-
W
K
-----------
F
H
P
---
F
A
D
E
-
S
N
S
L
----------
T
----------
L
N
W
S
P
T
L
E
L
Q
G
T
-
V
E
S
P
M
-----
T
---------------
P
S
Q
F
-
A
T
-
S
V
D
I
S
E
-
R
G
---------------------------------------------------------------
L
I
A
-------
T
----------
G
F
N
N
G
T
V
Q
I
S
E
L
S
T
L
R
P
L
Y
N
F
E
S
-----
Q
H
N
N
S
N
S
I
R
S
V
-----
K
F
S
P
Q
G
------
S
L
L
A
I
A
H
D
--
S
N
S
F
G
C
I
T
L
Y
E
T
E
F
-
G
E
----
R
I
---
G
S
------
L
S
V
P
-----
G
E
F
A
H
S
S
W
-
V
M
S
L
S
F
N
D
S
G
-----------
E
T
L
C
S
A
G
WDG
K
L
R
F
W
D
V
K
T
-------------------------
K
--
E
R
I
T
T
L
N
M
H
C
D
D
I
--------------------
E
I
E
E
D
I
L
A
V
D
E
H
G
-
D
---
S
L
A
E
P
G
V
F
D
V
K
-
F
L
K
K
G
W
R
------
S
G
M
G
A
D
-
L
N
-----
E
S
L
C
C
V
C
LDR
S
I
R
W
F
-------------------
R
E
A
G
--------------------------
23
Fugue
72.37
18%
-35
* C3 *
1DIO
3
?
A:
[1-551]
------------------------------------MRS
K
R
F
E
A
L
A
K
R
P
V
N
Q
-
D
--
G
F
V
K
E
W
I
E
E
-
G
F
IAMESPNDPK
P
S
I
K
I
V
------
N
------
G
------
A
--
V
T
E
L
----
D
G
K
P
V
S
D
F
D
L
I
D
--
H
F
I
A
-------
R
Y
--
G
-
I
N
-------------
L
N
R
A
E
E
V
M
A
---------
M
--------
D
S
-
V
K
L
A
-
N
M
L
C
D
P
-
N
V
K
R
S
------
E
I
V
P
L
T
T
A
M
T
P
A
---------------
K
I
V
---------------
E
V
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S
H
M
N
V
V
E
M
M
M
A
-
M
Q
K
M
R
A
R
--
R
T
P
S
Q
Q
A
-----
H
V
T
N
V
K
D
---
N
--------------
P
V
Q
I
-----
A
--------
A
D
A
A
E
G
A
W
R
G
F
D
E
----------
Q
E
T
T
V
A
V
A
R
Y
-
A
P
F
N
----------
A
----------
I
----
A
L
L
V
G
S
Q
-
V
G
R
P
G
V
L
-
T
Q
C
---------------
S
L
E
E
-
A
T
-
E
L
K
L
G
M
-
L
G
H
---
T
C
Y
A
E
T
I
SVYGT
E
P
V
F
T
-----------
D
G
D
DT
P
W
S
K
G
F
-------
L
---
A
S
S
Y
A
S
--
R
G
L
K
-------
M
----------
R
F
T
S
G
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G
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E
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Y
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M
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Y
L
E
A
R
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I
Y
I
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K
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A
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V
Q
G
L
QNGSV
S
C
I
G
V
P
S
A
V
PS
G
I
R
A
V
L
A
E
N
--
L
I
C
S
S
L
D
L
E
C
A
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S
N
-
D
Q
TFTH
S
D
M
R
R
T
A
------
R
L
L
M
-----
Q
F
L
P
G
T
D
F
-
I
S
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G
Y
S
A
V
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Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
----
N
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I
Q
R
D
L
K
VDGG
L
R
P
V
R
E
E
D
V
I
A
I
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N
K
A
A
R
A
L
Q
A
--
V
F
A
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G
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P
P
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-
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A
A
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AHGSKDMPERN
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
-
N
RN
G
L
E
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A
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A
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G
G
-
F
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D
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A
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D
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L
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I
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K
A
K
L
T
G
D
-
Y
L
HTS--
A
I
I
V
G
D
G
----
Q
V
L
S
AVNDVNDYAGPAT
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
ALDPN--------------
24
Fugue
72.07
17%
-48
- C4 -
4OPU
3
?
A:
[2-453]
-----------------------------------------------
M
K
E
L
K
Y
D
--
V
L
I
I
G
G
G
F
A
-
G
S
----------
S
A
A
Y
Q
L
------
S
------
R
------
R
G-
L
K
I
L
--
L
V
D
S
K
P
W
N
R
I
G
D
K
P
CG
D
A
V
S
-------
K
A
--
H
F
D
K
L
GMPYPKGEELEN
K
I
N
G
I
K
L
Y
S
PDMQ
T
V
W
T
V
N
--------
H
E
-
G
F
E
L
N
A
P
L
Y
N
Q
-
R
V
L
K
E
A
Q
D
R
G
V
E
I
W
D
L
T
T
A
M
K
P
I
---------------
F
E
D
---------------
G
Y
V
K
G
A
V
L
F
N
R
R
T
N
-
E
E
L
T
V
Y
----
S
----
K
-----
V
V
V
E
A
T
G
---
Y
--------------
S
R
S
F
-----
R
--------
S
K
L
P
P
E
L
P
I
-
T
E
D
----------
L
D
-----
D
K
D
-
A
D
V
A
----------
Y
----------
R
----
E
V
L
L
T
K
E
D
I
E
D
H
D
-
Y
-
L
R
I
F
I
D
QETSPG
G
Y
W
W
Y
F
P
K
G
K
N
K
V
-
N
V
G
L
G
I
-
Q
G
G
MGY
P
S
I
H
E
Y
Y
--------
K
K
-----------
Y
L
D
--
K
Y
A
P
D
V
-------
D
---
K
S
K
L
L
V
K
G
G
A
L
V
P
TRRPLY
T
----------
M
A
W
N
G
I
I
V
I
G
D
S
G
F
-------
T
V
N
-
P
V
H
G
G
G
K
G
S
A
M
I
S
G
-----
Y
C
A
A
K
A
------
I
L
S
A
F
E
T
G
------------------------
D
F
S
A
S
G
------
L
W
------------
D
M
N
-
I
C
Y
V
N
E
Y
G
A
K
Q
A
S
L
D
I
F
R
R
F
L
Q
K
L
S
N
D
D
----
I
N
Y
G
M
K
K
K
---------
I
I
K
E
E
D
L
L
E
A
S
-----------
E
K
G
-----------
D
L
H
L
-----------
S
V
A
D
K
A
M
-------------
R
V
I
S
G
L
G
R
P
S
-
L
L
F
K
L
K
A
V
A
E
S
M
K
K
I
K
E
L
Y
-
L
N
YPRSP
S
S
L
G
S
W
R
----
R
E
V
D
-------------------
N
V
L
T
E
F
N
K
S
L
S
-------------------
30
Fugue
70.73
14%
-62
- C1 -
4XGC
-
?
D:
[5-457]
-----------------------------------------
D
R
E
L
V
S
I
R
R
F
L
-
K
--
E
R
L
Q
R
-
D
Y
T
-
T
L
----------
R
G
Y
A
K
E
------
R
------
S
------
N
--
V
R
L
L
--
L
Q
R
T
A
E
M
G
---
E
S
N
--
S
L
L
L
L
G
P
RGSG
K
T
--
T
L
I
N
-------------
S
V
L
A
D
L
L
P
N
---------
K
--------
S
F
-
G
E
N
T
-
L
I
V
H
L
D
G
N
L
H
T
D
------
D
R
V
A
L
K
S
I
T
V
Q
M
---------------
Q
L
E
---------------
N
A
A
D
--
G
K
V
F
G
S
F
A
-
E
N
L
A
F
L
L
Q
C
L
K
----
S
-----
K
S
V
I
F
I
L
---
E
--------------
E
F
D
L
-----
F
--------
C
A
H
H
N
Q
T
L
L
-
Y
N
L
----------
F
D
V
---
S
Q
S
A
Q
A
P
I
C
----------
V
----------------
L
G
V
T
C
R
-
L
D
V
I
E
-
L
-
L
E
K
---------------
R
V
K
S
-
R
F
--------------
S
H
R
Q
V
F
L
--------
F
-----------------
P
S
L
R
R
F
-------
E
---
D
Y
V
D
L
C
--
R
D
L
L
-------
S
L
P
--------
T
G
N
S
L
L
L
A
A
E
K
I
Y
N
L
Q
N
I
Q
S
G
A
L
Y
-
F
S
R
N
H
F
D
P
G
E
Y
G
F
S
-----------------
P
R
L
R
D
A
W
N
--
K
Q
I
C
K
V
L
A
T
Q
Q
A
R
S
-
T
L
----
Q
A
L
H
D
F
D
------
I
S
E
A
-----
Y
L
K
N
F
L
F
R
-
L
V
A
------
H
L
R
P
Q
S
P
H
I
T
A
E
K
-
M
A
A
V
G
----
S
Q
F
E
G
D
---------------
D
K
I
E
L
L
C
G
L
S
V
L
E
--
L
C
L
I
I
A
I
K
H
H
S
Q
I
Y
---
D
R
D
S
-----------
F
N
F
E
I
I
Y
A
R
F
S
K
F
A
-
K
---
V
S
T
T
M
Q
A
V
E
R
S
-
I
V
L
K
A
F
E
H
L
R
I
A
E
L
I
M
P
L
T
K
V
Q
-----
K
E
F
E
M
H
K
----
L
A
L
T
-------------------
Y
S
Q
I
H
H
C
M
Q
R
Y
QALPT
E
V
A
Q
W
A
QSS-----
25
Fugue
68.92
21%
-63
- C2 -
4ONQ
1
?
A:
[7-353]
----------------------------------------R
L
P
K
P
M
I
----------------
G
F
-
G
V
----------
P
T
E
-
P
L
------
P
------
A
------
M
--
V
R
R
T
--
L
P
S
Q
A
V
G
P
P
-------
F
F
Y
Y
-------
E
N
--
V
A
L
A
-------------
P
K
G
V
W
D
T
I
S
---------
S
--------
S
L
Y
D
I
E
P
-
E
F
V
D
S
K
-
Y
F
----------
C
A
A
A
R
----------------------
K
R
---------------
G
Y
I
H
N
L
P
-----------------
V
E
----
N
-----
R
F
P
L
F
P
L
---
A
--------------
P
-----------------------------------------
R
T
---
I
H
E
A
-
L
P
L
S
----------
K
----------
K
----
W
W
P
S
W
D
P
-
R
T
K
L
N
-
C
-
L
Q
T
---------------
A
I
G
S
--------
A
Q
-
L
T
N
---
R
I
R
K
A
V
E
--------
D
F
-----------
D
G
E
--
P
-----------------
P
M
R
V
Q
--
K
F
V
L
-------
D
----------
Q
C
R
K
W
N
L
V
W
V
G
R
N
K
V
A
P
L
E
P
D
E
V
E
-
M
L
L
G
F
P
K
N
H
T
R
G
G
G
-----
I
-
S
R
T
D
------
R
Y
K
S
L
G
N
S
--
F
Q
V
D
T
V
A
Y
H
L
S
V
L
K
-
D
L
--------
F
P
G
------
G
I
N
V
-----
L
S
L
F
S
G
I
G
-
G
G
E
V
A
L
Y
R
L
G
I
-
P
L
N
T
V
V
S
V
-----------------
E
K
S
---------
E
V
N
R
D
I
V
R
S
W
W
E
Q
T
N
Q
------
R
G
N
L
I
H
F
N
D
V
Q
Q
L
N
G
D
R
L
-----------
E
Q
L
I
E
S
F
G
G
F
D
L
V
I
-
G
---
G
S
P
-------------------------------------
S
L
F
S
S
Y
----
V
R
I
L
-------------------
D
L
---
V
K
S
I
M
S
-------------------
29
Fugue
68.42
17%
-43
* C4 *
4USR
2
?
A:
[1-357]
--------------------------------------------
G
P
A
M
P
P
I
L
-
D
--
V
I
V
I
G
G
G
Q
A
-
A
L
----------
T
T
A
Y
F
L
R
-----
R
------
T
------
S
--
L
S
Y
L
--
L
L
D
E
----------------------------------------------------
Q
---------
P
--------
G
P
-
G
G
A
W
-
L
H
----------------
A
W
D
S
L
R
L
F
S
P
A
A
---------------
W
S
S
---------------
I
A
G
W
P
M
P
S
P
T
E
P
G
N
P
T
R
N
D
V
I
D
--
Y
L
----
R
-----
R
Y
E
D
R
Y
Q
---
F
--------------
P
I
Q
R
-----
P
--------
V
R
V
D
T
V
T
R
L
-
D
D
L
----------
W
R
V
---
Q
A
G
D
--------------------------
Q
----
Q
W
L
A
R
A
V
-
I
S
A
T
G
-
T
-
W
S
K
---------------
P
F
I
P
-
P
Y
-
E
-
G
R
E
L
-
F
Q
G
---
A
Q
I
H
S
A
H
--------
Y
R
-----------
T
P
A
--
P
F
A
G
K
R
V
M
V
V
G
GG
N
---
S
G
A
Q
V
L
--
A
E
L
S
-------
S
----------
V
S
E
T
L
W
I
T
Q
E
P
P
A
F
L
-------------
P
D
E
V
D
G
R
V
L
F
E
-----
R
A
T
A
R
W
------
K
A
Q
Q
E
G
R
S
--
I
D
E
P
--------
A
G
-
G
F
----
G
D
I
V
M
V
P
------
P
V
R
E
-----
A
R
E
R
-------
G
V
L
V
A
E
R
P
F
A
----------
R
F
T
E
T
G
----
V
E
W
A
D
G
R
R
---------
E
N
L
-------------
D
--
A
V
I
W
C
S
G
F
R
P
A
L
D
H
-
L
R
E
L
G
V
-----------
V
E
A
D
G
K
V
Q
V
E
D
T
R
V
V
K
---
Q
P
N
L
W
L
V
G
Y
G
D
-
W
T
G
M
A
----
S
A
T
L
I
G
V
T
R
T
-
A
R
-----
S
T
A
D
Q
V
V
----
Q
A
L
T
-------------------
A
T
P
---------------------------
7
PsiBlast_PDB
62.38
25%
0
- C- -
4HEA
-
1:
[53--156]
----------------------------------------------
V
I
E
E
V
K
-
R
--
S
G
L
R
G
R
G
G
A
-
G
F
----------
P
T
G
L
K
W
------
S
FMPKDD
G
------
K
--
Q
H
Y
L
--
I
C
N
A
D
E
S
E
P
G
S
F
K
D
--
R
Y
I
L
-------
E
D
--
V
P
H
L
-------------
L
I
E
G
M
I
L
A
G
---------
Y
--------
A
I
-
R
A
T
V
-
G
Y
I
Y
V
R
-
G
E
Y
R
R
------
A
A
D
R
L
E
Q
A
I
K
E
A
---------------
R
A
R
GYLGKNLFGTDFSFD
L
H
V
H
R
G
A
G
A
Y
I
C
G
E
-
E
T
A
L
M
N
S
--
L
E
----
G
LRANP
R
L
K
P
P
-----
F
--------------
P
A
Q
S
-----
G
LWGKP---
T
T
I
N
N
V
E
T
L
-
A
S
V
VPIMERGADW
F
A
Q
---
M
G
T
E
-
Q
S
K
G
----------
M
----------
K
----
L
Y
Q
I
S
G
P
-
V
K
R
P
G
-
V
-
Y
E
L
---------------
P
M
G
T
-
T
F
R
E
L
I
Y
E
W
-
A
G
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.38
25%
0
- C- -
2YBB
-
1:
[53--156]
----------------------------------------------
V
I
E
E
V
K
-
R
--
S
G
L
R
G
R
G
G
A
-
G
F
----------
P
T
G
L
K
W
------
S
FMPKDD
G
------
K
--
Q
H
Y
L
--
I
C
N
A
D
E
S
E
P
G
S
F
K
D
--
R
Y
I
L
-------
E
D
--
V
P
H
L
-------------
L
I
E
G
M
I
L
A
G
---------
Y
--------
A
I
-
R
A
T
V
-
G
Y
I
Y
V
R
-
G
E
Y
R
R
------
A
A
D
R
L
E
Q
A
I
K
E
A
---------------
R
A
R
GYLGKNLFGTDFSFD
L
H
V
H
R
G
A
G
A
Y
I
C
G
E
-
E
T
A
L
M
N
S
--
L
E
----
G
LRANP
R
L
K
P
P
-----
F
--------------
P
A
Q
S
-----
G
LWGKP---
T
T
I
N
N
V
E
T
L
-
A
S
V
VPIMERGADW
F
A
Q
---
M
G
T
E
-
Q
S
K
G
----------
M
----------
K
----
L
Y
Q
I
S
G
P
-
V
K
R
P
G
-
V
-
Y
E
L
---------------
P
M
G
T
-
T
F
R
E
L
I
Y
E
W
-
A
G
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.38
25%
0
- C- -
3M9S
-
1:
[53--155]
----------------------------------------------
V
I
E
E
V
K
-
R
--
S
G
L
R
G
R
G
G
A
-
G
F
----------
P
T
G
L
K
W
------
S
FMPKDD
G
------
K
--
Q
H
Y
L
--
I
C
N
A
D
E
S
E
P
G
S
F
K
D
--
R
Y
I
L
-------
E
D
--
V
P
H
L
-------------
L
I
E
G
M
I
L
A
G
---------
Y
--------
A
I
-
R
A
T
V
-
G
Y
I
Y
V
R
-
G
E
Y
R
R
------
A
A
D
R
L
E
Q
A
I
K
E
A
---------------
R
A
R
GYLGKNLFGTDFSFD
L
H
V
H
R
G
A
G
A
Y
I
C
G
E
-
E
T
A
L
M
N
S
--
L
E
----
G
LRANP
R
L
K
P
P
-----
F
--------------
P
A
Q
S
-----
G
LWGKP---
T
T
I
N
N
V
E
T
L
-
A
S
V
VPIMERGADW
F
A
Q
---
M
G
T
E
-
Q
S
K
G
----------
M
----------
K
----
L
Y
Q
I
S
G
P
-
V
K
R
P
G
-
V
-
Y
E
L
---------------
P
M
G
T
-
T
F
R
E
L
I
Y
E
W
-
A
G
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
62.38
25%
0
- C- -
3IAS
-
1:
[53--155]
----------------------------------------------
V
I
E
E
V
K
-
R
--
S
G
L
R
G
R
G
G
A
-
G
F
----------
P
T
G
L
K
W
------
S
FMPKDD
G
------
K
--
Q
H
Y
L
--
I
C
N
A
D
E
S
E
P
G
S
F
K
D
--
R
Y
I
L
-------
E
D
--
V
P
H
L
-------------
L
I
E
G
M
I
L
A
G
---------
Y
--------
A
I
-
R
A
T
V
-
G
Y
I
Y
V
R
-
G
E
Y
R
R
------
A
A
D
R
L
E
Q
A
I
K
E
A
---------------
R
A
R
GYLGKNLFGTDFSFD
L
H
V
H
R
G
A
G
A
Y
I
C
G
E
-
E
T
A
L
M
N
S
--
L
E
----
G
LRANP
R
L
K
P
P
-----
F
--------------
P
A
Q
S
-----
G
LWGKP---
T
T
I
N
N
V
E
T
L
-
A
S
V
VPIMERGADW
F
A
Q
---
M
G
T
E
-
Q
S
K
G
----------
M
----------
K
----
L
Y
Q
I
S
G
P
-
V
K
R
P
G
-
V
-
Y
E
L
---------------
P
M
G
T
-
T
F
R
E
L
I
Y
E
W
-
A
G
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.38
25%
0
- C- -
3IAM
-
1:
[53--155]
----------------------------------------------
V
I
E
E
V
K
-
R
--
S
G
L
R
G
R
G
G
A
-
G
F
----------
P
T
G
L
K
W
------
S
FMPKDD
G
------
K
--
Q
H
Y
L
--
I
C
N
A
D
E
S
E
P
G
S
F
K
D
--
R
Y
I
L
-------
E
D
--
V
P
H
L
-------------
L
I
E
G
M
I
L
A
G
---------
Y
--------
A
I
-
R
A
T
V
-
G
Y
I
Y
V
R
-
G
E
Y
R
R
------
A
A
D
R
L
E
Q
A
I
K
E
A
---------------
R
A
R
GYLGKNLFGTDFSFD
L
H
V
H
R
G
A
G
A
Y
I
C
G
E
-
E
T
A
L
M
N
S
--
L
E
----
G
LRANP
R
L
K
P
P
-----
F
--------------
P
A
Q
S
-----
G
LWGKP---
T
T
I
N
N
V
E
T
L
-
A
S
V
VPIMERGADW
F
A
Q
---
M
G
T
E
-
Q
S
K
G
----------
M
----------
K
----
L
Y
Q
I
S
G
P
-
V
K
R
P
G
-
V
-
Y
E
L
---------------
P
M
G
T
-
T
F
R
E
L
I
Y
E
W
-
A
G
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
62.38
25%
0
- C- -
3I9V
-
1:
[53--155]
----------------------------------------------
V
I
E
E
V
K
-
R
--
S
G
L
R
G
R
G
G
A
-
G
F
----------
P
T
G
L
K
W
------
S
FMPKDD
G
------
K
--
Q
H
Y
L
--
I
C
N
A
D
E
S
E
P
G
S
F
K
D
--
R
Y
I
L
-------
E
D
--
V
P
H
L
-------------
L
I
E
G
M
I
L
A
G
---------
Y
--------
A
I
-
R
A
T
V
-
G
Y
I
Y
V
R
-
G
E
Y
R
R
------
A
A
D
R
L
E
Q
A
I
K
E
A
---------------
R
A
R
GYLGKNLFGTDFSFD
L
H
V
H
R
G
A
G
A
Y
I
C
G
E
-
E
T
A
L
M
N
S
--
L
E
----
G
LRANP
R
L
K
P
P
-----
F
--------------
P
A
Q
S
-----
G
LWGKP---
T
T
I
N
N
V
E
T
L
-
A
S
V
VPIMERGADW
F
A
Q
---
M
G
T
E
-
Q
S
K
G
----------
M
----------
K
----
L
Y
Q
I
S
G
P
-
V
K
R
P
G
-
V
-
Y
E
L
---------------
P
M
G
T
-
T
F
R
E
L
I
Y
E
W
-
A
G
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
62.38
25%
0
- C- -
2FUG
-
1:
[53--150]
----------------------------------------------
V
I
E
E
V
K
-
R
--
S
G
L
R
G
R
G
G
A
-
G
F
----------
P
T
G
L
K
W
------
S
FMPKDD
G
------
K
--
Q
H
Y
L
--
I
C
N
A
D
E
S
E
P
G
S
F
K
D
--
R
Y
I
L
-------
E
D
--
V
P
H
L
-------------
L
I
E
G
M
I
L
A
G
---------
Y
--------
A
I
-
R
A
T
V
-
G
Y
I
Y
V
R
-
G
E
Y
R
R
------
A
A
D
R
L
E
Q
A
I
K
E
A
---------------
R
A
R
GYLGKNLFGTDFSFD
L
H
V
H
R
G
A
G
A
Y
I
C
G
E
-
E
T
A
L
M
N
S
--
L
E
----
G
LRANP
R
L
K
P
P
-----
F
--------------
P
A
Q
S
-----
G
LWGKP---
T
T
I
N
N
V
E
T
L
-
A
S
V
VPIMERGADW
F
A
Q
---
M
G
T
E
-
Q
S
K
G
----------
M
----------
K
----
L
Y
Q
I
S
G
P
-
V
K
R
P
G
-
V
-
Y
E
L
---------------
P
M
G
T
-
T
F
R
E
L
I
Y
E
W
-
A
G
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
58.20
11%
-43
- C4 -
1Y8Q
3
SAE2_HUMAN
B:
[6-550]
-----------------------------------------
G
L
P
R
E
L
A
E
A
V
A
-
G
G
R
V
L
V
V
G
A
G
G
I
-
G
C
----------
E
L
L
K
N
L
------
V
------
L
------
T
GF
S
H
I
D
--
L
I
D
L
D
T
I
D
V
S
N
L
N
R
--
Q
F
L
F
-------
Q
K
--
K
H
V
G
-------------
R
S
K
A
Q
V
A
K
E
---------
S
V
L
Q
F
Y
PKA
N
I
-
V
A
Y
H
-
D
S
I
M
N
P
-
D
Y
N
V
E
------
F
F
R
Q
F
I
L
V
M
N
A
L
---------------
D
N
R
---------------
A
A
R
N
H
V
N
R
M
C
L
A
A
D
-
V
P
L
I
E
S
G
--
T
A
----
G
-----
Y
L
G
Q
V
T
T
---
I
K
K
GVTECYECHPKP
T
Q
R
T
-----
F
--------
P
G
A
T
I
R
N
T
P
-
S
E
P
----------
I
H
C
---
I
V
W
A
-
K
Y
L
F
----------
N
----------
Q
----
L
F
G
E
E
D
A
-
D
Q
E
V
S
-
P
D
R
A
D
---------------
P
E
A
A
-
W
E
-
T
K
E
W
A
K
-
S
T
G
---
Y
D
P
V
K
L
F
--------
T
K
-----------
L
F
K
--
D
D
I
R
Y
L
-------
L
---
T
M
D
K
L
W
--
R
K
R
K
-------
P
----------
P
V
P
L
D
W
A
E
V
Q
S
Q
L
G
L
K
D
Q
Q
V
L
D
V
K
-
S
Y
A
R
L
F
S
K
S
I
E
T
L
R
-----
V
H
L
A
E
K
G-----
D
G
A
E
L
I
W
D
--
K
D
D
P
S
A
M
D
F
V
T
S
A
A
-
N
L
----
R
M
H
I
F
S
M
N
M
K
S
R
F
D
I
K
S
-----
M
A
G
N
I
I
P
A
-
I
A
T
T
N
A
V
I
A
G
L
I
V
L
E
G
L
K
I
L
S
G
K
I
D
Q
C
R
----
T
I
F
L
N
K
Q
P
---------
N
P
R
K
K
L
L
V
P
C
A
L
D
P
P
N
P
NC
Y
V
C
A
S
K
P
E
V
T
V
R
L
N
-
V
H
K
V
T
V
-----------
L
T
L
Q
D
K
I
V
K
E
K
F
A
M
-
V
---
A
P
D
V
Q
I
E
D
G
K
G
T
I
L
I
S
S
E
E
G
E
T
E
A
N
N
H
K
K
L
S
-
E
F
-----
G
I
R
N
G
S
R
----
L
Q
A
D
-------------------
D
F
L
Q
D
Y
T
L
L
I
N
I
L
H
S
EDLGKDVEFEVVGDA
14
PsiBlast_PDB
56.66
26%
-61
- C5 -
2WS3
4
SDHB_ECOLI
B:
[149-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
I
L
C
A
-----
C
C
S
T
S
C
------
P
S
F
W
W
N
P
D
KF
I
G
P
A
G
L
L
A
A
Y
R
F
L
I
-
D
S
----
R
D
T
E
T
D
S
------
R
L
D
G
L
SDAF
S
V
F
R
C
H
S
I
-
M
N
C
V
S
V
C
P
K
G
L
N
P
T
R
A
I
G
H
I
K
S
M
L
L
Q
R
N
----
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
56.47
26%
-63
- C5 -
1NEK
5
SDHB_ECOLI
B:
[149-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
I
L
C
A
-----
C
C
S
T
S
C
------
P
S
F
W
W
N
P
D
KF
I
G
P
A
G
L
L
A
A
Y
R
F
L
I
-
D
S
----
R
D
T
E
T
D
S
------
R
L
D
G
L
SDAF
S
V
F
R
C
H
S
I
-
M
N
C
V
S
V
C
P
K
G
L
N
P
T
R
A
I
G
H
I
K
S
M
L
L
Q
R
N
----
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
56.38
26%
-63
- C5 -
2WDQ
4
SDHB_ECOLI
B:
[149-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
I
L
C
A
-----
C
C
S
T
S
C
------
P
S
F
W
W
N
P
D
KF
I
G
P
A
G
L
L
A
A
Y
R
F
L
I
-
D
S
----
R
D
T
E
T
D
S
------
R
L
D
G
L
SDAF
S
V
F
R
C
H
S
I
-
M
N
C
V
S
V
C
P
K
G
L
N
P
T
R
A
I
G
H
I
K
S
M
L
L
Q
R
N
----
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
55.87
26%
-62
- C5 -
1NEN
5
SDHB_ECOLI
B:
[149-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
I
L
C
A
-----
C
C
S
T
S
C
------
P
S
F
W
W
N
P
D
KF
I
G
P
A
G
L
L
A
A
Y
R
F
L
I
-
D
S
----
R
D
T
E
T
D
S
------
R
L
D
G
L
SDAF
S
V
F
R
C
H
S
I
-
M
N
C
V
S
V
C
P
K
G
L
N
P
T
R
A
I
G
H
I
K
S
M
L
L
Q
R
N
----
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------