@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1451: (2016-03-24 )
MEIIKISPRGYCYGVIDAMVIAKNASLDPNLPRPIHILGMIVHNKHVTDAFESIGIYTVDGANREEILDKITTGTVIFTAHGVSPSVKAKAVAKGLTTIDATCPDVLHTYNLILEKQAAGYEIIYIGKKGHPEPEGAYGTAPDVVHLVETKADIDALSLLSDKIFVTNQTTMSKWDVADLMHYIKGKFPKAIQHQEICMATQVRQEAVALQAKDADLTIVVGDPRSNNTARLAQVSIEKAGTKAYRIADITELDIEWIKDAKKVAVTAGASTPTQLVREVLLFLEQFDAADKTTWKREHNQDFERILPKTKNKYMAEKRSQRLAHLKNGGS
Atome Classification :
(60 SA)
-.........10........20........30........40........50........60........70...-.....80........90........100.......110.......120.......130.......-----140---.---......150.......160........170.......180.......190--.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290....-...300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
E
I
I
K
ISPRG
Y
C
Y
G
V
I
D
A
M
V
IAKNASLDPNLPRP
I
H
I
L
G
M
I
VHNK
H
V
T
D
A
F
E
SI
G
I
Y
T
VDGA
N
R
E
E
I
L
D
K
ITT
G
-
T
V
I
F
T
AHGVSP
S
V
K
A
K
A
V
AKGLTTIDAT
C
P
D
V
L
H
T
Y
N
L
I
L
EKQAAG
Y
E
I
I
Y
IGKKGHPEPEGAYG-----TAP---
D
---
V
V
H
L
VETKA
D
I
D
A
L
S
L
LS-D
K
I
F
V
TNQTTMSKW
D
V
A
D
L
M
H
Y
I
KGKFP
K
A
I
--
Q
H
Q
E
I
C
M
A
T
Q
V
R
Q
E
A
V
ALQAKDA
D
L
T
I
V
V
GDPRSNNT
A
R
L
A
Q
V
S
I
EKAG
T
K
A
Y
R
I
A
D
I
T
E
L
D
I
E
W
I
KDA
K
K
V
A
V
TAGAS
T
P
T
Q
L
V
R
E
V
L
L
F
L
E
Q
FDAADKTTWK-REHNQ
D
F
E
R
I
L
P
KTK
N
K
Y
M
A
E
K
R
S
Q
R
L
A
H
L
KNGGS
42
PsiBlast_CBE
94.87
36%
-92
- C9 -
3UTD
2
ISPH_ECOLI
B:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
31
PsiBlast_CBE
94.70
36%
-91
- C9 -
4MUX
2
?
B:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
23
PsiBlast_CBE
94.68
36%
-92
- C9 -
3KEF
2
ISPH_ECOLI
B:
[11-316]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
32
PsiBlast_CBE
94.59
36%
-91
- C9 -
4EB3
2
ISPH_ECOLI
B:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
45
PsiBlast_CBE
94.58
36%
-88
- C9 -
4H4E
2
ISPH_ECOLI
B:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
41
PsiBlast_CBE
94.56
36%
-90
- C9 -
3UV3
2
ISPH_ECOLI
B:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
40
PsiBlast_CBE
94.53
36%
-90
- C9 -
3UV6
2
ISPH_ECOLI
B:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
44
PsiBlast_CBE
94.52
36%
-89
- C9 -
3URK
2
ISPH_ECOLI
B:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
36
PsiBlast_CBE
94.51
36%
-90
- C9 -
3UWM
2
ISPH_ECOLI
B:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
43
PsiBlast_CBE
94.49
36%
-90
- C9 -
3UTC
2
ISPH_ECOLI
B:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
49
PsiBlast_CBE
94.44
36%
-89
- C9 -
4H4C
2
ISPH_ECOLI
B:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
38
PsiBlast_CBE
94.30
36%
-91
- C9 -
3UV7
2
ISPH_ECOLI
B:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
52
PsiBlast_CBE
94.16
35%
-91
- C9 -
3SZU
2
ISPH_ECOLI
A:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
Q
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
3
PsiBlast_PDB
94.14
36%
-89
- C9 -
3KEF
2
ISPH_ECOLI
A:
[11-316]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
19
PsiBlast_PDB
94.05
36%
-90
- C9 -
3UV3
2
ISPH_ECOLI
A:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
4
PsiBlast_PDB
94.03
36%
-87
- C9 -
3KEL
2
ISPH_ECOLI
A:
[11-316]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
26
PsiBlast_CBE
94.02
36%
-90
- C9 -
3ZGN
2
ISPH_ECOLI
B:
[17-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
33
PsiBlast_CBE
93.97
36%
-90
- C9 -
3SZO
2
ISPH_ECOLI
B:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
8
PsiBlast_PDB
93.94
36%
-91
- C9 -
4EB3
2
ISPH_ECOLI
A:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
27
PsiBlast_CBE
93.86
36%
-89
- C9 -
3ZGL
2
ISPH_ECOLI
B:
[17-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
9
PsiBlast_PDB
93.80
36%
-89
- C9 -
4MUY
2
?
A:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
34
PsiBlast_CBE
93.76
36%
-90
- C9 -
3SZL
2
ISPH_ECOLI
B:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
46
PsiBlast_CBE
93.75
36%
-90
- C9 -
4H4E
2
ISPH_ECOLI
A:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
20
PsiBlast_PDB
93.68
36%
-89
- C9 -
3UV6
2
ISPH_ECOLI
A:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
28
PsiBlast_CBE
93.62
36%
-90
- C9 -
4MV5
2
?
B:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
47
PsiBlast_CBE
93.60
36%
-91
- C9 -
4H4D
2
ISPH_ECOLI
B:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
30
PsiBlast_CBE
93.58
36%
-93
- C9 -
4MUY
2
?
B:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
18
PsiBlast_PDB
93.48
36%
-88
- C9 -
3UTD
2
ISPH_ECOLI
A:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
12
PsiBlast_PDB
93.48
36%
-94
- C9 -
4MV5
2
?
A:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
21
PsiBlast_CBE
93.47
36%
-89
- C9 -
3KEM
2
ISPH_ECOLI
B:
[11-316]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
17
PsiBlast_PDB
93.44
36%
-89
- C9 -
3UTC
2
ISPH_ECOLI
A:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
14
PsiBlast_PDB
93.39
36%
-88
- C9 -
3SZL
2
ISPH_ECOLI
A:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
2
PsiBlast_PDB
93.39
36%
-91
- C9 -
3KE9
2
ISPH_ECOLI
A:
[11-316]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
7
PsiBlast_PDB
93.32
36%
-89
- C9 -
3ZGN
2
ISPH_ECOLI
A:
[17-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
10
PsiBlast_PDB
93.29
36%
-91
- C9 -
4MV0
2
?
A:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
37
PsiBlast_CBE
93.26
36%
-90
- C9 -
3UWM
2
ISPH_ECOLI
A:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
5
PsiBlast_PDB
93.21
36%
-89
- C9 -
3KEM
2
ISPH_ECOLI
A:
[11-316]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
50
PsiBlast_CBE
93.18
36%
-89
- C9 -
4H4C
2
ISPH_ECOLI
A:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
11
PsiBlast_PDB
93.18
36%
-89
- C9 -
4MUX
2
?
A:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
35
PsiBlast_CBE
93.16
36%
-89
- C9 -
3F7T
6
ISPH_ECOLI
B:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
15
PsiBlast_PDB
93.11
36%
-87
- C9 -
3SZO
2
ISPH_ECOLI
A:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
48
PsiBlast_CBE
93.09
36%
-89
- C9 -
4H4D
2
ISPH_ECOLI
A:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
39
PsiBlast_CBE
93.06
36%
-90
- C9 -
3UV7
2
ISPH_ECOLI
A:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
1
PsiBlast_PDB
93.06
36%
-87
- C9 -
3KE8
2
ISPH_ECOLI
A:
[11-316]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
29
PsiBlast_CBE
93.05
36%
-91
- C9 -
4MV0
2
?
B:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
16
PsiBlast_PDB
93.00
36%
-89
- C9 -
3URK
2
ISPH_ECOLI
A:
[9-314]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
22
PsiBlast_CBE
92.71
36%
-90
- C9 -
3KEL
2
ISPH_ECOLI
B:
[11-316]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
6
PsiBlast_PDB
92.70
36%
-89
- C9 -
3ZGL
2
ISPH_ECOLI
A:
[17-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
25
PsiBlast_CBE
92.63
36%
-90
- C9 -
3KE8
2
ISPH_ECOLI
B:
[11-316]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
13
PsiBlast_PDB
92.56
36%
-89
- C9 -
3F7T
7
ISPH_ECOLI
A:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
24
PsiBlast_CBE
92.54
36%
-89
- C9 -
3KE9
2
ISPH_ECOLI
B:
[11-316]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
56
PsiBlast_CBE
92.45
35%
-89
- C9 -
3T0G
2
ISPH_ECOLI
A:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
C
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
53
PsiBlast_CBE
92.43
35%
-98
- C9 -
3T0F
2
ISPH_ECOLI
B:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
------
T
M
G
Q-----------G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
54
PsiBlast_CBE
92.42
35%
-91
- C9 -
3T0F
2
ISPH_ECOLI
A:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
D
V
E
G
T
M
G
Q
Y---
S
N
P
---
E
G
--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
51
PsiBlast_CBE
92.21
35%
-90
- C9 -
3SZU
2
ISPH_ECOLI
B:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
Q
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
55
PsiBlast_CBE
91.92
35%
-91
* C9 *
3T0G
2
ISPH_ECOLI
B:
[13-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
--
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
-----
E
Q
I
S
E
V
P
D
G
A
-
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
QY---
S
N
P
---
E
G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
C
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
GP
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
-
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
--
V
P
K
----------------------
59
Fugue
79.59
30%
-97
- C9 -
3DNF
2
ISPH_AQUAE
A:
[1-281]
M
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
S
L
--
K
E
S
Q
G
K
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
V
F
P
S
Q
G
-------
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
-----
Y
L
R
---
A
C
N
G
K
G
I
V
V
E
T
L
E
D
I
G
E
A
L
K
-
H
-
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
K
--
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
-
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
I
---------------------------------------------
69
HHSearch
78.88
30%
-92
- C9 -
3DNF
2
ISPH_AQUAE
A:
[2-281]
-
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
S
L
K
E
--
S
Q
G
K
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
V
F
P
S
Q
G
-
E
E
F
K
-----
E
G
D
-
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
-----
Y
L
R
A
C
N
G
---
K
G
I
V
V
E
T
L
E
D
I
G
E
A
L
-
K
H
-
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
K
--
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
-
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
I
---------------------------------------------
58
PsiBlast_CBE
75.43
31%
-87
- C9 -
3DNF
2
ISPH_AQUAE
A:
[11-274]
----------
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
-
S
L
K
E
S
Q
G
K
-
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
V
F
P
S
Q
G
E
E
F
K
E
------
G
D
-
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
L
R
A
C
N
G
K
---
G
---
I
V
--
V
E
T
L
E
D
I
G
E
-
A
L
K
H
-
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
K
--
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
-
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
----------------------------------------------------
57
PsiBlast_CBE
75.35
31%
-85
- C9 -
3DNF
2
ISPH_AQUAE
B:
[11-274]
----------
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
-
S
L
K
E
S
Q
G
K
-
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
V
F
P
S
Q
G
E
E
F
K
E
------
G
D
-
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
YLRAC
N
G
K
---
G
---
I
V
--
V
E
T
L
E
D
I
G
E
-
A
L
K
H
-
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
K
--
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
-
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
----------------------------------------------------