@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1532: (2016-03-25 )
MDERIISSETVDAEEVSFETSLRPQNLSQYIGQDKVKNNLTVFIEAATLRNEALDHVLLYGPPGLGKTTLAMVIASEMGSQIKTTSGPAIERPGDLATILTSLEPGDVLFIDEIHRLSRAIEEILYPAMEDYCLDIVIGTGPTARSVRLDLPPFTLIGATTRAGLLSAPLRDRFGVIDHLEFYTEEQLTEIVLRTSNILDTKIDDLGAREIARRSRGTPRIANRLLKRVRDFAQVRGNGTVTEKLAKEALTLLQVDPRGLDTIDQKLLHTIIQSFRGGPVGLDTIAASIGEERETIEDMQEPYLLQIGFLQRTPRGRIVTETAYNHLGISYEKEV
Atome Classification :
(20 SA)
.........10........20......-..30........40........-------50........60........70........80----.--........90----..---------------------------------.----...----...100-.------.-----......110.......----120---.........130.......140.......150.......160-----------.--......170.......180.......190......-------.200.......210...-....220-........230......--.240.......250....---...260.......270.......280.......290.......300.......310.......320.......330...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDERIISSETVDAEE
V
S
FETSL
R
P
Q
N
L
-
S
Q
Y
I
G
Q
D
K
VKNN
L
T
V
F
I
E
A
A
TL-------
R
N
EAL
D
H
V
L
L
YGPPGL
G
K
T
T
L
A
M
V
I
A
S
EMGS-----Q--IKTTSGPAI-----ER---------------------------------P----G
D
L
----
A
T
I
L
-T-S------L-----EPG
D
V
L
F
I
D
E
I
H
R
L
S
R
----
A
-----
I
E
E
I
L
Y
P
A
M
E
D
Y
C
L
D
I
V
IGTGPTA
R
S
V
R
LDLPP
F
T
L
IGATTR-----------A--GLLSA
P
L
R
D
R
F
G
V
I
D
H
L
E
F
Y
T
E
E
Q
L
T
E
I
V
L
RTSNI-------LDT
K
I
D
DL
G
A
R
E
I
A
R
RS-RGT
P
R
-
I
-
A
N
R
L
L
K
R
V
R
D
F
A
Q
VRGN--G
T
V
T
E
K
L
A
K
E
A
L
T
L
L
QVD---PRG
L
D
T
I
D
Q
K
L
L
H
T
I
I
Q
S
FRGGPV
G
L
D
T
I
A
A
S
IG
E
E
R
E
T
I
E
D
MQE
P
Y
L
L
Q
I
G
F
L
QRTPRG
R
I
V
T
ETAYNHLG
I
S
YEKEV
116
HHSearch
92.80
56%
-99
* C3 *
1IN4
5
RUVB_THEMA
A:
[17-329]
-------------------
Q
F
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
-----
N
--
I
H
V
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
D
M
----
A
A
I
L
-
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
----
A
-----
V
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
---------------
I
Q
P
F
T
L
V
G
A
T
T
R
-----------
S
--
G
L
L
S
S
P
L
R
S
R
F
G
I
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
-------
M
D
V
E
I
E
D
A
A
A
E
M
I
A
K
R
S
-
R
G
T
P
R
-
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
--
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
N
I
D
---
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
P
V
G
L
N
A
L
A
A
S
L
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
K
Y
E
V
P
---
4
PsiBlast_PDB
92.53
55%
-102
- C3 -
1IN8
1
RUVB_THEMA
A:
[17-324]
----------------
Q
F
---
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
-----
N
--
I
H
V
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
D
M
----
A
A
I
L
-
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
----
A
-----
V
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
---------------
I
Q
P
F
T
L
V
G
A
T
V
R
-----------
S
--
G
L
L
S
S
P
L
R
S
R
F
G
I
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
-------
M
D
V
E
I
E
D
A
A
A
E
M
I
A
K
R
S
-
R
G
T
P
R
-
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
--
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
N
I
D
---
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
P
V
G
L
N
A
L
A
A
S
L
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
--------
3
PsiBlast_PDB
92.33
55%
-102
- C3 -
1IN6
2
RUVB_THEMA
A:
[17-324]
----------------
Q
F
---
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
R
T
T
L
A
H
I
I
A
S
E
L
Q
T
-----
N
--
I
H
V
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
D
M
----
A
A
I
L
-
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
----
A
-----
V
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
-------------
I
D
I
Q
P
F
T
L
V
G
A
T
T
R
-----------
S
--
G
L
L
S
S
P
L
R
S
R
F
G
I
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
-------
M
D
V
E
I
E
D
A
A
A
E
M
I
A
K
R
S
-
R
G
T
P
R
-
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
--
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
N
I
D
---
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
P
V
G
L
N
A
L
A
A
S
L
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
--------
7
PsiBlast_PDB
91.79
58%
-105
- C3 -
1IXS
1
RUVB_THET8
B:
[5-313]
--------------------
A
L
R
P
K
T
L
-
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
-------
R
K
E
P
L
E
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
V
-----
N
--
L
R
V
T
S
G
P
A
I
-----
E
K
---------------------------------
P
----
G
D
L
----
A
A
I
L
A
N
-
S
------
L
-----
E
E
G
D
I
L
F
I
D
E
I
H
R
L
S
R
----
Q
-----
A
E
E
H
L
Y
P
A
M
E
D
F
V
M
D
I
V
I
G
Q
G
P
A
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
-----------
P
--
G
L
I
T
A
P
L
L
S
R
F
G
I
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
-------
L
G
V
R
I
T
E
E
A
A
L
E
I
G
R
R
S
-
R
G
T
M
R
-
V
-
A
K
R
L
F
R
R
V
R
D
F
A
Q
V
A
G
E
--
E
V
I
T
R
E
R
A
L
E
A
L
A
A
L
G
L
D
---
E
L
G
L
E
K
R
D
R
E
I
L
E
V
L
I
L
R
F
G
G
G
P
V
G
L
A
T
L
A
T
A
L
S
E
D
P
G
T
L
E
E
V
H
E
P
Y
L
I
R
Q
G
L
L
K
R
T
P
R
G
R
V
A
T
E
L
A
Y
R
H
L
G
-------
2
PsiBlast_PDB
91.70
55%
-98
- C3 -
1IN5
1
RUVB_THEMA
A:
[17-324]
----------------
Q
F
---
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
-----
N
--
I
H
V
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
D
M
----
A
A
I
L
-
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
----
A
-----
V
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
I
M
------------
D
I
Q
P
F
T
L
V
G
S
T
T
R
-----------
S
--
G
L
L
S
S
P
L
R
S
R
F
G
I
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
-------
M
D
V
E
I
E
D
A
A
A
E
M
I
A
K
R
S
-
R
G
T
P
R
-
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
--
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
N
I
D
---
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
P
V
G
L
N
A
L
A
A
S
L
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
--------
1
PsiBlast_PDB
91.66
56%
-99
- C3 -
1IN4
5
RUVB_THEMA
A:
[17-324]
----------------
Q
F
---
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
-----
N
--
I
H
V
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
D
M
----
A
A
I
L
-
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
----
A
-----
V
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
---------------
I
Q
P
F
T
L
V
G
A
T
T
R
-----------
S
--
G
L
L
S
S
P
L
R
S
R
F
G
I
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
-------
M
D
V
E
I
E
D
A
A
A
E
M
I
A
K
R
S
-
R
G
T
P
R
-
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
--
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
N
I
D
---
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
P
V
G
L
N
A
L
A
A
S
L
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
--------
5
PsiBlast_PDB
91.37
55%
-104
- C3 -
1IN7
3
RUVB_THEMA
A:
[17-324]
----------------
Q
F
---
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
-----
N
--
I
H
V
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
D
M
----
A
A
I
L
-
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
----
A
-----
V
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
---------------
I
Q
P
F
T
L
V
G
A
T
T
R
-----------
S
--
G
L
L
S
S
P
L
R
S
A
F
G
I
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
-------
M
D
V
E
I
E
D
A
A
A
E
M
I
A
K
R
S
-
R
G
T
P
R
-
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
--
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
N
I
D
---
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
P
V
G
L
N
A
L
A
A
S
L
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
--------
115
HHSearch
91.27
57%
-101
- C3 -
1HQC
2
RUVB_THET8
A:
[5-317]
--------------------
A
L
R
P
K
T
L
-
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
-------
R
K
E
P
L
E
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
V
-----
N
--
L
R
V
T
S
G
P
A
I
-----
E
K
---------------------------------
P
----
G
D
L
----
A
A
I
L
-
A
-
N
S-----
L
-----
E
E
G
D
I
L
F
I
D
E
I
H
R
L
S
R
----
Q
-----
A
E
E
H
L
Y
P
A
M
E
D
F
V
M
D
I
V
I
G
Q
G
P
A
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
-----------
P
--
G
L
I
T
A
P
L
L
S
R
F
G
I
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
-------
L
G
V
R
I
T
E
E
A
A
L
E
I
G
R
R
S
-
R
G
T
M
R
-
V
-
A
K
R
L
F
R
R
V
R
D
F
A
Q
V
A
G
E
--
E
V
I
T
R
E
R
A
L
E
A
L
A
A
L
G
L
D
---
E
L
G
L
E
K
R
D
R
E
I
L
E
V
L
I
L
R
F
G
G
G
P
V
G
L
A
T
L
A
T
A
L
S
E
D
P
G
T
L
E
E
V
H
E
P
Y
L
I
R
Q
G
L
L
K
R
T
P
R
G
R
V
P
T
E
L
A
Y
R
H
L
G
Y
P
P
P
---
114
HHSearch
91.07
55%
-102
- C3 -
3PFI
1
?
A:
[23-332]
---------------------
L
R
P
S
N
F
-
D
G
Y
I
G
Q
E
S
I
K
K
N
L
N
V
F
I
A
A
A
K
K
-------
R
N
E
C
L
D
H
I
L
F
S
G
P
A
G
L
G
K
T
T
L
A
N
I
I
S
Y
E
M
S
A
-----
N
--
I
K
T
T
A
A
P
M
I
-----
E
K
---------------------------------
S
----
G
D
L
----
A
A
I
L
-
T
-
N
------
L
-----
S
E
G
D
I
L
F
I
D
E
I
H
R
L
S
P
----
A
-----
I
E
E
V
L
Y
P
A
M
E
D
Y
R
L
---------
A
Q
T
I
K
I
D
L
P
K
F
T
L
I
G
A
T
T
R
-----------
A
--
G
M
L
S
N
P
L
R
D
R
F
G
M
Q
F
R
L
E
F
Y
K
D
S
E
L
A
L
I
L
Q
K
A
A
L
K
-------
L
N
K
T
C
E
E
K
A
A
L
E
I
A
K
R
S
-
R
S
T
P
R
-
I
-
A
L
R
L
L
K
R
V
R
D
F
A
D
V
N
D
E
--
E
I
I
T
E
K
R
A
N
E
A
L
N
S
L
G
V
N
---
E
L
G
F
D
A
M
D
L
R
Y
L
E
L
L
T
A
-
A
K
Q
K
P
I
G
L
A
S
I
A
A
A
L
S
E
D
E
N
T
I
E
D
V
I
E
P
Y
L
L
A
N
G
Y
I
E
R
T
A
K
G
R
I
A
S
A
K
S
Y
S
A
L
K
L
N
Y
E
---
104
Fugue
90.95
57%
-101
- C3 -
1HQC
2
RUVB_THET8
A:
[5-318]
--------------------
A
L
R
P
K
T
L
-
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
-------
R
K
E
P
L
E
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
V
-----
N
--
L
R
V
T
S
G
P
A
I
-----
E
K
---------------------------------
P
----
G
D
L
----
A
A
I
L
-
A
N
S
------
L
-----
E
E
G
D
I
L
F
I
D
E
I
H
R
L
S
R
----
Q
-----
A
E
E
H
L
Y
P
A
M
E
D
F
V
M
D
I
V
I
G
Q
G
P
A
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
-----------
P
--
G
L
I
T
A
P
L
L
S
R
F
G
I
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
-------
L
G
V
R
I
T
E
E
A
A
L
E
I
G
R
R
S
-
R
G
T
M
R
-
V
-
A
K
R
L
F
R
R
V
R
D
F
A
Q
V
A
G
E
--
E
V
I
T
R
E
R
A
L
E
A
L
A
A
L
G
L
D
---
E
L
G
L
E
K
R
D
R
E
I
L
E
V
L
I
L
R
F
G
G
G
P
V
G
L
A
T
L
A
T
A
L
S
E
D
P
G
T
L
E
E
V
H
E
P
Y
L
I
R
Q
G
L
L
K
R
T
P
R
G
R
V
P
T
E
L
A
Y
R
H
L
G
Y
P
P
P
V
--
6
PsiBlast_PDB
90.94
55%
-100
- C3 -
1J7K
4
RUVB_THEMA
A:
[19-324]
---------------------
L
R
P
K
S
L
-
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
A
L
E
A
A
K
M
-------
R
G
E
V
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
-----
N
--
I
H
V
T
S
G
P
V
L
-----
V
K
---------------------------------
Q
----
G
D
M
----
A
A
I
L
-
T
-
S
------
L
-----
E
R
G
D
V
L
F
I
D
E
I
H
R
L
N
K
----
A
-----
V
E
E
L
L
Y
S
A
I
E
D
F
Q
I
D
I
------------
I
D
I
Q
P
F
T
L
V
G
A
T
T
R
-----------
S
--
G
L
L
S
S
P
L
R
S
R
F
G
I
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
-------
M
D
V
E
I
E
D
A
A
A
E
M
I
A
K
R
S
-
R
G
T
G
R
-
I
-
A
I
R
L
T
K
R
V
R
D
M
L
T
V
V
K
A
--
D
R
I
N
T
D
I
V
L
K
T
M
E
V
L
N
I
D
---
D
E
G
L
D
E
F
D
R
K
I
L
K
T
I
I
E
I
Y
R
G
G
P
V
G
L
N
A
L
A
A
S
L
G
V
E
A
D
T
L
S
E
V
Y
E
P
Y
L
L
Q
A
G
F
L
A
R
T
P
R
G
R
I
V
T
E
K
A
Y
K
H
L
--------
8
PsiBlast_PDB
90.75
54%
-103
- C3 -
3PFI
1
?
A:
[23-332]
---------------------
L
R
P
S
N
F
-
D
G
Y
I
G
Q
E
S
I
K
K
N
L
N
V
F
I
A
A
A
K
K
-------
R
N
E
C
L
D
H
I
L
F
S
G
P
A
G
L
G
K
T
T
L
A
N
I
I
S
Y
E
M
S
A
-----
N
--
I
K
T
T
A
A
P
M
I
-----
E
K
---------------------------------
S
----
G
D
L
----
A
A
I
L
-
T
-
N
------
L
-----
S
E
G
D
I
L
F
I
D
E
I
H
R
L
S
P
----
A
-----
I
E
E
V
L
Y
P
A
M
E
D
Y
R
L
---------
A
Q
T
I
K
I
D
L
P
K
F
T
L
I
G
A
T
T
R
-----------
A
--
G
M
L
S
N
P
L
R
D
R
F
G
M
Q
F
R
L
E
F
Y
K
D
S
E
L
A
L
I
L
Q
K
A
A
L
K
-------
L
N
K
T
C
E
E
K
A
A
L
E
I
A
K
R
S
-
R
S
T
P
R
-
I
-
A
L
R
L
L
K
R
V
R
D
F
A
D
V
N
D
E
--
E
I
I
T
E
K
R
A
N
E
A
L
N
S
L
G
V
N
---
E
L
G
F
D
A
M
D
L
R
Y
L
E
-
L
L
T
A
A
K
Q
K
P
I
G
L
A
S
I
A
A
A
L
S
E
D
E
N
T
I
E
D
V
I
E
P
Y
L
L
A
N
G
Y
I
E
R
T
A
K
G
R
I
A
S
A
K
S
Y
S
A
L
K
L
N
Y
E
---
9
PsiBlast_PDB
90.65
58%
-101
- C3 -
1HQC
2
RUVB_THET8
A:
[5-313]
--------------------
A
L
R
P
K
T
L
-
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
-------
R
K
E
P
L
E
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
V
-----
N
--
L
R
V
T
S
G
P
A
I
-----
E
K
---------------------------------
P
----
G
D
L
----
A
A
I
L
A
N
-
S
------
L
-----
E
E
G
D
I
L
F
I
D
E
I
H
R
L
S
R
----
Q
-----
A
E
E
H
L
Y
P
A
M
E
D
F
V
M
D
I
V
I
G
Q
G
P
A
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
-----------
P
--
G
L
I
T
A
P
L
L
S
R
F
G
I
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
-------
L
G
V
R
I
T
E
E
A
A
L
E
I
G
R
R
S
-
R
G
T
M
R
-
V
-
A
K
R
L
F
R
R
V
R
D
F
A
Q
V
A
G
E
--
E
V
I
T
R
E
R
A
L
E
A
L
A
A
L
G
L
D
---
E
L
G
L
E
K
R
D
R
E
I
L
E
V
L
I
L
R
F
G
G
G
P
V
G
L
A
T
L
A
T
A
L
S
E
D
P
G
T
L
E
E
V
H
E
P
Y
L
I
R
Q
G
L
L
K
R
T
P
R
G
R
V
P
T
E
L
A
Y
R
H
L
G
-------
21
PsiBlast_CBE
89.09
58%
-101
- C3 -
1HQC
2
RUVB_THET8
B:
[5-313]
--------------------
A
L
R
P
K
T
L
-
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
-------
R
K
E
P
L
E
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
V
-----
N
--
L
R
V
T
S
G
P
A
I
-----
E
K
---------------------------------
P
----
G
D
L
----
A
A
I
L
A
N
-
S
------
L
-----
E
E
G
D
I
L
F
I
D
E
I
H
R
L
S
R
----
Q
-----
A
E
E
H
L
Y
P
A
M
E
D
F
V
M
D
I
V
I
G
Q
G
P
A
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
-----------
P
--
G
L
I
T
A
P
L
L
S
R
F
G
I
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
-------
L
G
V
R
I
T
E
E
A
A
L
E
I
G
R
R
S
-
R
G
T
M
R
-
V
-
A
K
R
L
F
R
R
V
R
D
F
A
Q
V
A
G
E
--
E
V
I
T
R
E
R
A
L
E
A
L
A
A
L
G
L
D
---
E
L
G
L
E
K
R
D
R
E
I
L
E
V
L
I
L
R
F
G
G
G
P
V
G
L
A
T
L
A
T
A
L
S
E
D
P
G
T
L
E
E
V
H
E
P
Y
L
I
R
Q
G
L
L
K
R
T
P
R
G
R
V
P
T
E
L
A
Y
R
H
L
G
-------
10
PsiBlast_PDB
85.02
58%
-92
- C3 -
1IXR
1
RUVB_THET8
C:
[5-312]
--------------------
A
L
R
P
K
T
L
-
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
-------
R
K
E
P
L
E
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
V
-----
N
--
L
R
V
T
S
G
P
A
I
-----
E
K
---------------------------------
P
----
G
D
L
----
A
A
I
L
A
N
-
S
------
L
-----
E
E
G
D
I
L
F
I
D
E
I
H
R
L
S
R
----
Q
-----
A
E
E
H
L
Y
P
A
M
E
D
F
V
M
D
I
V
I
G
Q
G
P
A
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
-----------
P
--
G
L
I
T
A
P
L
L
S
R
F
G
I
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
-------
L
G
V
R
I
T
E
E
A
A
L
E
I
G
R
R
S
-
R
G
T
M
R
-
V
-
A
K
R
L
F
R
R
V
R
D
F
A
Q
V
A
G
E
--
E
V
I
T
R
E
R
A
L
E
A
L
A
A
L
G
L
D
---
E
L
G
L
E
K
R
D
R
E
I
L
E
V
L
I
L
R
F
G
G
G
P
V
G
L
A
T
L
A
T
A
L
S
E
D
P
G
T
L
E
E
V
H
E
P
Y
L
I
R
Q
G
L
L
K
R
T
P
R
G
R
V
A
T
E
L
A
R
R
H
L
--------
119
HHSearch
55.79
28%
-74
- C3 -
3PVS
1
RARA_ECOLI
A:
[14-256]
---------------
Q
P
L
A
A
R
M
R
P
E
N
L
-
A
Q
Y
I
G
Q
Q
H
L
L
A
A
G
K
P
L
P
R
A
I
E
---------
A
G
H
L
H
S
M
I
L
W
G
P
P
G
T
G
K
T
T
L
A
E
V
I
A
R
Y
A
N
A
-----
D
--
V
E
R
I
S
A
V
T
S
-----
G
----------------------------------
V
----
K
E
I
----
R
E
A
I
-
E
-
R
A
R
Q
N
R
N
A
-----
G
R
R
T
I
L
F
V
D
E
V
H
R
F
---------------
A
F
L
P
H
I
E
D
G
--------------------
T
I
T
F
I
G
A
T
T
E
-----------
N
PS
F
E
L
N
S
A
L
L
S
R
A
R
-
V
Y
L
L
K
S
L
S
T
E
D
I
E
Q
V
L
T
Q
A
M
E
D
KTRGYGG
Q
D
I
V
L
P
D
E
T
R
R
A
I
A
E
L
V
-
N
G
D
A
R
-
R
-
A
L
N
T
L
E
M
M
A
D
M
A
E
V
D
D
S
GK
R
V
L
K
P
E
L
L
T
E
I
A
G
E
--------------------------------------------------------------------------------------
134
HHSearch
54.19
19%
-79
- C3 -
3D8B
2
FIGL1_HUMAN
A:
[75-315]
------------------
M
D
H
G
P
P
V
N
W
-
E
D
I
A
G
V
E
F
A
K
A
T
I
K
E
I
V
V
W
P
M
L
R
P
DIFTG
L
R
G
P
P
K
G
I
L
L
F
G
P
P
G
T
G
K
T
L
I
G
K
C
I
A
S
Q
S
G
A
-----
T
--
F
F
S
I
S
A
S
S
L
-----
T
S
KWVG
E
G
---------------------------
E
----
K
M
V
----
R
A
L
F
-
A
-
V
------
A
R
C
---
Q
Q
P
A
V
I
F
I
D
E
I
D
S
L
L
S
----
Q
E
S
S
R
R
I
K
T
E
F
L
V
Q
L
D
G
------------------
S
E
D
R
I
L
V
V
G
A
T
N
R
-----------
P
--
Q
E
I
D
E
A
A
R
R
R
L
V
K
R
L
Y
I
P
L
P
E
A
S
A
R
K
Q
I
V
I
N
L
M
S
K
-------
E
Q
C
C
L
S
E
E
E
I
E
Q
I
V
Q
Q
S
-
D
A
F
S
G
-
A
D
M
T
Q
L
C
R
E
A
S
L
G
P
I
R
S
--------------------------------------------------------------------------------------------------------
125
HHSearch
51.63
19%
-74
- C3 -
1IQP
1
RFCS_PYRFU
A:
[7-232]
---------
E
V
K
V
L
E
K
P
W
V
E
K
Y
R
P
Q
R
L
-
D
D
I
V
G
Q
E
H
I
V
K
R
L
K
H
Y
V
K
T
------------
G
S
M
P
H
L
L
F
A
G
P
P
G
V
G
K
T
T
A
A
L
A
L
A
R
E
L
F
G
ENWRH
N
--
F
L
E
L
N
A
S
D
E
-----
R
G
---------------------------------
I
----
N
V
I
R
E
K
V
K
E
F
A
-
R
-
T
------
K
PIGG-
A
S
F
K
I
I
F
L
D
E
A
D
A
L
T
Q
----
D
-----
A
Q
Q
A
L
R
R
T
M
E
M
F
S
------------------
S
N
V
R
F
I
L
S
C
N
Y
-----------
S
--
S
K
I
I
E
P
I
Q
S
R
C
A
I
-
F
R
F
R
P
L
R
D
E
D
I
A
K
R
L
R
Y
I
A
E
N
-------
E
G
L
E
L
T
E
E
G
L
Q
A
I
L
Y
I
A
-
E
G
D
M
R
-
R
-
A
I
N
I
L
Q
A
A
A
A
L
D
K
-------
K
I
T
D
E
N
V
F
M
V
A
S
---------------------------------------------------------------------------------------
129
HHSearch
51.57
18%
-85
- C3 -
3VFD
1
SPAST_HUMAN
A:
[103-339]
---------------
N
E
I
V
D
N
G
T
A
V
K
F
-
D
D
I
A
G
Q
D
L
A
K
Q
A
L
Q
E
I
V
I
L
P
S
L
R
PELFTG
L
R
A
P
A
R
G
L
L
L
F
G
P
P
G
N
G
K
T
M
L
A
K
A
V
A
A
E
S
N
A
-----
T
--
F
F
N
I
S
A
A
S
L
-------G--------------------------------
E
----
K
L
V
----
R
A
L
F
-
A
-
V
------
A
R
E
---
L
Q
P
S
I
I
F
I
D
Q
V
D
S
L
L
-DA
S
R
R
-----
L
K
T
E
F
L
I
E
F
D
G
V
Q
-------------------
R
V
L
V
M
G
A
T
N
R
-----------
P
--
Q
E
L
D
E
A
V
L
R
R
F
I
K
R
V
Y
V
S
L
P
N
E
E
T
R
L
L
L
L
K
N
L
L
C
K
-------
Q
G
S
P
L
T
Q
K
E
L
A
Q
L
A
R
M
T
-
D
G
Y
S
G
S
D
-
L
T
A
L
A
K
D
A
A
L
G
P
I
R
E
--------------------------------------------------------------------------------------------------------
121
HHSearch
51.39
20%
-75
- C3 -
3UK6
1
?
A:
[28-341]
------------
I
R
G
L
G
L
D
D
A
L
E
P
R
Q
A
S
Q
G
M
V
G
Q
L
A
A
R
R
A
A
G
V
V
L
E
M
I
R
E
-------
G
K
I
A
G
R
A
V
L
I
A
G
Q
P
G
T
G
K
T
A
I
A
M
G
M
A
Q
A
L
G
P
-----
D
T
P
F
T
A
I
A
G
S
E
I
FSLEM
S
K
T
E
A
L
T
Q
A
F
R
R
S
I
G
V
R
ITVS
L
H
E
I
D
V
I
N
SFLALF
K
S
E
V
R
E
Q
I
----
N
A
K
V
-
A
-
E
------
W
R
E
E
GK-
I
P
G
V
L
F
I
D
E
V
H
M
L
D
I
----
E
-----
S
F
S
F
L
N
R
A
L
E
S
D
M
------------------
A
P
V
L
I
M
A
T
N
R
G
ITRIRGTSYQS
P
--
H
G
I
P
I
D
L
L
D
R
L
L
I
-
V
S
T
T
P
Y
S
E
K
D
T
K
Q
I
L
R
I
R
C
E
E
-------
E
D
V
E
M
S
E
D
A
Y
T
V
L
T
R
I
G
L
E
T
S
L
R
-
Y
-
A
I
Q
L
I
T
A
A
S
L
V
C
R
K
R
K
G
--
T
E
V
Q
V
D
D
I
K
R
V
Y
S
L
F
L
D
E
S
R
S
T
Q
Y
M
K
--------------------------------------------------------------------------