@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2340: (2016-04-02 )
MKNYLSLSEEVKQAKAEGKAIVALESTIISHGMPYPQNVEMARDVEQIIRDNGAVPATIALIDGKIKIGLSDEELELFAKSSNVAKVSRRDIGYLIATKQLGATTVAATMICAELAEIGIFVTGGIGGVHRGAETTMDVSADLEELAKTNVAVVCAGAKSILDLNLTMEYLETKGVPVIGYQTDVLPAFYTRSSDVELTLRADTPEVIAESLKAKWDLQIEGGAVITNPIPEEFAMDEKVINDVIQTALKEAEENHIHGKDVTPFLLGKVKELTDGKSLEANIELVKHNALIGTQIAVAYQNI
Atome Classification :
(20 SA)
------------.........10---.........20........30........40-........-------50........60.......-----------------------------.---70........80..-......--------.90------........100.......110.......-----120..-.....130.......140-------------.......150------.........-----160.......170.......180.---......190..--.....200....-------....210.....-..220---.----..-----......230.....-..240-.......250.......260.......270...-....280-------....-----....290..---------------.....300.---------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MK
N
Y
L
S
L
S
E
E
----
V
K
Q
A
KAEG
K
A
I
V
A
L
E
S
T
I
I
SHGMPYPQ
N
V
E
M
-
A
R
D
V
E
Q
I
I
-------RDNGAV
P
A
T
I
A
L
ID
G
K
I
K
I-----------------------------G---L
S
D
E
E
L
E
L
F
AK-SS-N
V
A
K
VS--------RRD------
I
G
Y
L
I
A
TKQLG
A
T
T
V
A
A
T
M
I
C
A
E
L
A
E
I
G
-----
I
F
V
TG-GIGGVHRGAETTM
D
V
S
A
D
-------------
L
E
E
L
AKT
N
--------
V
A
V
V
CAGA
K
-----
S
I
L
D
L
N
L
T
M
E
Y
L
ETKG
V
P
V
I
G
YQT---DVL
P
A
F
YTRSS--
D
V
E
L
T
L
-RAD
T
P
-------
E
V
I
A
E
S
LKA
K
W
D
-
L
Q
I
-----E----G
G
-----
A
V
ITNPI
P
E
E
FA
M
D
-
E
K
V
I
N
-
D
V
I
Q
T
A
L
K
E
A
EENHIHGKDV
T
P
F
L
L
G
K
V
K
E
LTD-GKSL
E
A
--------
N
I
E
L
-----
V
K
HNA
L
I
G
T
---------------
Q
I
A
V
A
YQNI---------------------------------------------
17
PsiBlast_CBE
99.41
58%
-101
- C4 -
4GIK
3
PSUG_ECOLI
B:
[34-333]
----------------
L
Q
I
S
P
E
----
V
Q
D
A
L
K
N
K
K
P
V
V
A
L
E
S
T
I
I
S
H
G
M
P
F
P
Q
N
A
Q
T
-
A
I
E
V
E
E
T
I
-------
R
K
Q
G
A
V
P
A
T
I
A
I
I
G
G
V
M
K
V
-----------------------------
G
---
L
S
K
E
E
I
E
L
L
G
R
E
G
H
-
N
V
T
K
V
S
--------
R
R
D
------
L
P
F
V
V
A
A
G
K
N
G
A
T
T
V
A
S
T
M
I
I
A
A
L
A
G
I
K
-----
V
F
A
T
G
-
G
I
G
G
V
H
R
G
A
E
H
T
F
D
I
S
A
D
-------------
L
Q
E
L
A
N
T
N
--------
V
T
V
V
C
A
G
A
K
-----
S
I
L
D
L
G
L
T
T
E
Y
L
E
T
F
G
V
P
L
I
G
Y
Q
T
---
K
A
L
P
A
F
F
C
R
T
S
--
P
F
D
V
S
I
-
R
L
D
S
A
-------
S
E
I
A
R
A
M
V
V
K
W
Q
-
S
G
L
-----
N
----
G
G
-----
L
V
V
A
N
P
I
P
E
Q
F
A
M
P
-
E
H
T
I
N
-
A
A
I
D
Q
A
V
A
E
A
E
A
Q
G
V
I
G
K
E
S
T
P
F
L
L
A
R
V
A
E
L
T
G
-
G
D
S
L
K
S
--------
N
I
Q
L
-----
V
F
N
N
A
I
L
A
S
---------------
E
I
A
K
E
Y
Q
R
L
---------------------------------------------
18
PsiBlast_CBE
99.38
58%
-104
- C4 -
4GIJ
2
PSUG_ECOLI
B:
[34-333]
----------------
L
Q
I
S
P
E
----
V
Q
D
A
L
K
N
K
K
P
V
V
A
L
E
S
T
I
I
S
H
---
F
P
Q
N
A
Q
T
-
A
I
E
V
E
E
T
I
-------
R
K
Q
G
A
V
P
A
T
I
A
I
I
G
G
V
M
K
V
-----------------------------
G
---
L
S
K
E
E
I
E
L
L
G
R
E
G
H
-
N
V
T
K
V
S
--------
R
R
D
------
L
P
F
V
V
A
A
G
K
N
G
A
T
T
V
A
S
T
M
I
I
A
A
L
A
G
I
K
-----
V
F
A
T
G
-
G
I
G
G
V
H
R
G
A
E
H
T
F
D
I
S
A
D
-------------
L
Q
E
L
A
N
T
N
--------
V
T
V
V
C
A
G
A
K
-----
S
I
L
D
L
G
L
T
T
E
Y
L
E
T
F
G
V
P
L
I
G
Y
Q
T
---
K
A
L
P
A
F
F
C
R
T
S
--
P
F
D
V
S
I
-
R
L
D
S
A
-------
S
E
I
A
R
A
M
V
V
K
W
Q
-
S
G
L
-----
N
----
G
G
-----
L
V
V
A
N
P
I
P
E
Q
F
A
M
P
-
E
H
T
I
N
-
A
A
I
D
Q
A
V
A
E
A
E
A
Q
G
V
I
G
K
E
S
T
P
F
L
L
A
R
V
A
E
L
T
G
-
G
D
S
L
K
S
--------
N
I
Q
L
-----
V
F
N
N
A
I
L
A
S
---------------
E
I
A
K
E
Y
Q
R
L
---------------------------------------------
1
PsiBlast_PDB
98.96
58%
-105
- C4 -
4GIJ
2
PSUG_ECOLI
A:
[34-333]
----------------
L
Q
I
S
P
E
----
V
Q
D
A
L
K
N
K
K
P
V
V
A
L
E
S
T
I
I
S
H
G
M
P
F
P
Q
N
A
Q
T
-
A
I
E
V
E
E
T
I
-------
R
K
Q
G
A
V
P
A
T
I
A
I
I
G
G
V
M
K
V
-----------------------------
G
---
L
S
K
E
E
I
E
L
L
G
R
E
G
H
-
N
V
T
K
V
S
--------
R
R
D
------
L
P
F
V
V
A
A
G
K
N
G
A
T
T
V
A
S
T
M
I
I
A
A
L
A
G
I
K
-----
V
F
A
T
G
-
G
I
G
G
V
H
R
G
A
E
H
T
F
D
I
S
A
D
-------------
L
Q
E
L
A
N
T
N
--------
V
T
V
V
C
A
G
A
K
-----
S
I
L
D
L
G
L
T
T
E
Y
L
E
T
F
G
V
P
L
I
G
Y
Q
T
---
K
A
L
P
A
F
F
C
R
T
S
--
P
F
D
V
S
I
-
R
L
D
S
A
-------
S
E
I
A
R
A
M
V
V
K
W
Q
-
S
G
L
-----
N
----
G
G
-----
L
V
V
A
N
P
I
P
E
Q
F
A
M
P
-
E
H
T
I
N
-
A
A
I
D
Q
A
V
A
E
A
E
A
Q
G
V
I
G
K
E
S
T
P
F
L
L
A
R
V
A
E
L
T
G
---
S
L
K
S
--------
N
I
Q
L
-----
V
F
N
N
A
I
L
A
S
---------------
E
I
A
K
E
Y
Q
R
L
---------------------------------------------
3
PsiBlast_PDB
98.70
58%
-103
- C4 -
4GIL
3
PSUG_ECOLI
A:
[34-333]
----------------
L
Q
I
S
P
E
----
V
Q
D
A
L
K
N
K
K
P
V
V
A
L
E
S
T
I
I
S
H
G
M
P
F
P
Q
N
A
Q
T
-
A
I
E
V
E
E
T
I
-------
R
K
Q
G
A
V
P
A
T
I
A
I
I
G
G
V
M
K
V
-----------------------------
G
---
L
S
K
E
E
I
E
L
L
G
R
E
G
H
-
N
V
T
K
V
S
--------
R
R
D
------
L
P
F
V
V
A
A
G
K
N
G
A
T
T
V
A
S
T
M
I
I
A
A
L
A
G
I
K
-----
V
F
A
T
G
-
G
I
G
G
V
H
R
G
A
E
H
T
F
D
I
S
A
D
-------------
L
Q
E
L
A
N
T
N
--------
V
T
V
V
C
A
G
A
K
-----
S
I
L
D
L
G
L
T
T
E
Y
L
E
T
F
G
V
P
L
I
G
Y
Q
T
---
K
A
L
P
A
F
F
C
R
T
S
--
P
F
D
V
S
I
-
R
L
D
S
A
-------
S
E
I
A
R
A
M
V
V
K
W
Q
-
S
G
L
-----
N
----
G
G
-----
L
V
V
A
N
P
I
P
E
Q
F
A
M
P
-
E
H
T
I
N
-
A
A
I
D
Q
A
V
A
E
A
E
A
Q
G
V
I
G
K
E
S
T
P
F
L
L
A
R
V
A
E
L
T
G
-
G
D
S
L
K
S
--------
N
I
Q
L
-----
V
F
N
N
A
I
L
A
S
---------------
E
I
A
K
E
Y
Q
R
L
---------------------------------------------
15
PsiBlast_CBE
98.45
58%
-100
- C4 -
4GIL
3
PSUG_ECOLI
B:
[34-333]
----------------
L
Q
I
S
P
E
----
V
Q
D
A
L
K
N
K
K
P
V
V
A
L
E
S
T
I
I
S
H
G
M
P
F
P
Q
N
A
Q
T
-
A
I
E
V
E
E
T
I
-------
R
K
Q
G
A
V
P
A
T
I
A
I
I
G
G
V
M
K
V
-----------------------------
G
---
L
S
K
E
E
I
E
L
L
G
R
E
G
H
-
N
V
T
K
V
S
--------
R
R
D
------
L
P
F
V
V
A
A
G
K
N
G
A
T
T
V
A
S
T
M
I
I
A
A
L
A
G
I
K
-----
V
F
A
T
G
-
G
I
G
G
V
H
R
G
A
E
H
T
F
D
I
S
A
D
-------------
L
Q
E
L
A
N
T
N
--------
V
T
V
V
C
A
G
A
K
-----
S
I
L
D
L
G
L
T
T
E
Y
L
E
T
F
G
V
P
L
I
G
Y
Q
T
---
K
A
L
P
A
F
F
C
R
T
S
--
P
F
D
V
S
I
-
R
L
D
S
A
-------
S
E
I
A
R
A
M
V
V
K
W
Q
-
S
G
L
-----
N
----
G
G
-----
L
V
V
A
N
P
I
P
E
Q
F
A
M
P
-
E
H
T
I
N
-
A
A
I
D
Q
A
V
A
E
A
E
A
Q
G
V
I
G
K
E
S
T
P
F
L
L
A
R
V
A
E
L
T
G
-
G
D
S
L
K
S
--------
N
I
Q
L
-----
V
F
N
N
A
I
L
A
S
---------------
E
I
A
K
E
Y
Q
R
L
---------------------------------------------
14
PsiBlast_CBE
98.39
58%
-101
- C4 -
4GIL
3
PSUG_ECOLI
C:
[34-333]
----------------
L
Q
I
S
P
E
----
V
Q
D
A
L
K
N
K
K
P
V
V
A
L
E
S
T
I
I
S
H
G
M
P
F
P
Q
N
A
Q
T
-
A
I
E
V
E
E
T
I
-------
R
K
Q
G
A
V
P
A
T
I
A
I
I
G
G
V
M
K
V
-----------------------------
G
---
L
S
K
E
E
I
E
L
L
G
R
E
G
H
-
N
V
T
K
V
S
--------
R
R
D
------
L
P
F
V
V
A
A
G
K
N
G
A
T
T
V
A
S
T
M
I
I
A
A
L
A
G
I
K
-----
V
F
A
T
G
-
G
I
G
G
V
H
R
G
A
E
H
T
F
D
I
S
A
D
-------------
L
Q
E
L
A
N
T
N
--------
V
T
V
V
C
A
G
A
K
-----
S
I
L
D
L
G
L
T
T
E
Y
L
E
T
F
G
V
P
L
I
G
Y
Q
T
---
K
A
L
P
A
F
F
C
R
T
S
--
P
F
D
V
S
I
-
R
L
D
S
A
-------
S
E
I
A
R
A
M
V
V
K
W
Q
-
S
G
L
-----
N
----
G
G
-----
L
V
V
A
N
P
I
P
E
Q
F
A
M
P
-
E
H
T
I
N
-
A
A
I
D
Q
A
V
A
E
A
E
A
Q
G
V
I
G
K
E
S
T
P
F
L
L
A
R
V
A
E
L
T
G
-
G
D
S
L
K
S
--------
N
I
Q
L
-----
V
F
N
N
A
I
L
A
S
---------------
E
I
A
K
E
Y
Q
R
L
---------------------------------------------
19
PsiBlast_CBE
98.09
57%
-104
- C4 -
4GIM
3
PSUG_ECOLI
C:
[34-333]
----------------
L
Q
I
S
P
E
----
V
Q
D
A
L
K
N
K
K
P
V
V
A
L
E
S
T
I
I
S
H
G
M
P
F
P
Q
N
A
Q
T
-
A
I
E
V
E
E
T
I
-------
R
K
Q
G
A
V
P
A
T
I
A
I
I
G
G
V
M
K
V
-----------------------------
G
---
L
S
K
E
E
I
E
L
L
G
R
E
G
H
-
N
V
T
K
V
S
--------
R
R
D
------
L
P
F
V
V
A
A
G
K
N
G
A
T
T
V
A
S
T
M
I
I
A
A
L
A
G
I
K
-----
V
F
A
T
G
-
G
I
G
G
V
H
R
G
A
E
H
T
F
D
I
S
A
D
-------------
L
Q
E
L
A
N
T
N
--------
V
T
V
V
C
A
G
A
A
-----
S
I
L
D
L
G
L
T
T
E
Y
L
E
T
F
G
V
P
L
I
G
Y
Q
T
---
K
A
L
P
A
F
F
C
R
T
S
--
P
F
D
V
S
I
-
R
L
D
S
A
-------
S
E
I
A
R
A
M
V
V
K
W
Q
-
S
G
L
-----
N
----
G
G
-----
L
V
V
A
N
P
I
P
E
Q
F
A
M
P
-
E
H
T
I
N
-
A
A
I
D
Q
A
V
A
E
A
E
A
Q
G
V
I
G
K
E
S
T
P
F
L
L
A
R
V
A
E
L
T
G
-
G
D
S
L
K
S
--------
N
I
Q
L
-----
V
F
N
N
A
I
L
A
S
---------------
E
I
A
K
E
Y
Q
R
L
---------------------------------------------
20
PsiBlast_CBE
97.93
57%
-102
- C4 -
4GIM
3
PSUG_ECOLI
B:
[34-333]
----------------
L
Q
I
S
P
E
----
V
Q
D
A
L
K
N
K
K
P
V
V
A
L
E
S
T
I
I
S
H
G
M
P
F
P
Q
N
A
Q
T
-
A
I
E
V
E
E
T
I
-------
R
K
Q
G
A
V
P
A
T
I
A
I
I
G
G
V
M
K
V
-----------------------------
G
---
L
S
K
E
E
I
E
L
L
G
R
E
G
H
-
N
V
T
K
V
S
--------
R
R
D
------
L
P
F
V
V
A
A
G
K
N
G
A
T
T
V
A
S
T
M
I
I
A
A
L
A
G
I
K
-----
V
F
A
T
G
-
G
I
G
G
V
H
R
G
A
E
H
T
F
D
I
S
A
D
-------------
L
Q
E
L
A
N
T
N
--------
V
T
V
V
C
A
G
A
A
-----
S
I
L
D
L
G
L
T
T
E
Y
L
E
T
F
G
V
P
L
I
G
Y
Q
T
---
K
A
L
P
A
F
F
C
R
T
S
--
P
F
D
V
S
I
-
R
L
D
S
A
-------
S
E
I
A
R
A
M
V
V
K
W
Q
-
S
G
L
-----
N
----
G
G
-----
L
V
V
A
N
P
I
P
E
Q
F
A
M
P
-
E
H
T
I
N
-
A
A
I
D
Q
A
V
A
E
A
E
A
Q
G
V
I
G
K
E
S
T
P
F
L
L
A
R
V
A
E
L
T
G
-
G
D
S
L
K
S
--------
N
I
Q
L
-----
V
F
N
N
A
I
L
A
S
---------------
E
I
A
K
E
Y
Q
R
L
---------------------------------------------
2
PsiBlast_PDB
97.91
58%
-102
- C4 -
4GIK
3
PSUG_ECOLI
A:
[34-333]
----------------
L
Q
I
S
P
E
----
V
Q
D
A
L
K
N
K
K
P
V
V
A
L
E
S
T
I
I
S
H
G
M
P
F
P
Q
N
A
Q
T
-
A
I
E
V
E
E
T
I
-------
R
K
Q
G
A
V
P
A
T
I
A
I
I
G
G
V
M
K
V
-----------------------------
G
---
L
S
K
E
E
I
E
L
L
G
R
E
G
H
-
N
V
T
K
V
S
--------
R
R
D
------
L
P
F
V
V
A
A
G
K
N
G
A
T
T
V
A
S
T
M
I
I
A
A
L
A
G
I
K
-----
V
F
A
T
G
-
G
I
G
G
V
H
R
G
A
E
H
T
F
D
I
S
A
D
-------------
L
Q
E
L
A
N
T
N
--------
V
T
V
V
C
A
G
A
K
-----
S
I
L
D
L
G
L
T
T
E
Y
L
E
T
F
G
V
P
L
I
G
Y
Q
T
---
K
A
L
P
A
F
F
C
R
T
S
--
P
F
D
V
S
I
-
R
L
D
S
A
-------
S
E
I
A
R
A
M
V
V
K
W
Q
-
S
G
L
-----
N
----
G
G
-----
L
V
V
A
N
P
I
P
E
Q
F
A
M
P
-
E
H
T
I
N
-
A
A
I
D
Q
A
V
A
E
A
E
A
Q
G
V
I
G
K
E
S
T
P
F
L
L
A
R
V
A
E
L
T
G
-
G
D
S
L
K
S
--------
N
I
Q
L
-----
V
F
N
N
A
I
L
A
S
---------------
E
I
A
K
E
Y
Q
R
L
---------------------------------------------
16
PsiBlast_CBE
97.69
58%
-103
- C4 -
4GIK
2
PSUG_ECOLI
C:
[34-333]
----------------
L
Q
I
S
P
E
----
V
Q
D
A
L
K
N
K
K
P
V
V
A
L
E
S
T
I
I
S
H
--
P
F
P
Q
N
A
Q
T
-
A
I
E
V
E
E
T
I
-------
R
K
Q
G
A
V
P
A
T
I
A
I
I
G
G
V
M
K
V
-----------------------------
G
---
L
S
K
E
E
I
E
L
L
G
R
E
G
H
-
N
V
T
K
V
S
--------
R
R
D
------
L
P
F
V
V
A
A
G
K
N
G
A
T
T
V
A
S
T
M
I
I
A
A
L
A
G
I
K
-----
V
F
A
T
G
-
G
I
G
G
V
H
R
G
A
E
H
T
F
D
I
S
A
D
-------------
L
Q
E
L
A
N
T
N
--------
V
T
V
V
C
A
G
A
K
-----
S
I
L
D
L
G
L
T
T
E
Y
L
E
T
F
G
V
P
L
I
G
Y
Q
T
---
K
A
L
P
A
F
F
C
R
T
S
--
P
F
D
V
S
I
-
R
L
D
S
A
-------
S
E
I
A
R
A
M
V
V
K
W
Q
-
S
G
L
-----
N
----
G
G
-----
L
V
V
A
N
P
I
P
E
Q
F
A
M
P
-
E
H
T
I
N
-
A
A
I
D
Q
A
V
A
E
A
E
A
Q
G
V
I
G
K
E
S
T
P
F
L
L
A
R
V
A
E
L
T
G
-
G
D
S
L
K
S
--------
N
I
Q
L
-----
V
F
N
N
A
I
L
A
S
---------------
E
I
A
K
E
Y
Q
R
L
---------------------------------------------
4
PsiBlast_PDB
97.37
57%
-101
- C4 -
4GIM
3
PSUG_ECOLI
A:
[34-333]
----------------
L
Q
I
S
P
E
----
V
Q
D
A
L
K
N
K
K
P
V
V
A
L
E
S
T
I
I
S
H
G
M
P
F
P
Q
N
A
Q
T
-
A
I
E
V
E
E
T
I
-------
R
K
Q
G
A
V
P
A
T
I
A
I
I
G
G
V
M
K
V
-----------------------------
G
---
L
S
K
E
E
I
E
L
L
G
R
E
G
H
-
N
V
T
K
V
S
--------
R
R
D
------
L
P
F
V
V
A
A
G
K
N
G
A
T
T
V
A
S
T
M
I
I
A
A
L
A
G
I
K
-----
V
F
A
T
G
-
G
I
G
G
V
H
R
G
A
E
H
T
F
D
I
S
A
D
-------------
L
Q
E
L
A
N
T
N
--------
V
T
V
V
C
A
G
A
A
-----
S
I
L
D
L
G
L
T
T
E
Y
L
E
T
F
G
V
P
L
I
G
Y
Q
T
---
K
A
L
P
A
F
F
C
R
T
S
--
P
F
D
V
S
I
-
R
L
D
S
A
-------
S
E
I
A
R
A
M
V
V
K
W
Q
-
S
G
L
-----
N
----
G
G
-----
L
V
V
A
N
P
I
P
E
Q
F
A
M
P
-
E
H
T
I
N
-
A
A
I
D
Q
A
V
A
E
A
E
A
Q
G
V
I
G
K
E
S
T
P
F
L
L
A
R
V
A
E
L
T
G
-
G
D
S
L
K
S
--------
N
I
Q
L
-----
V
F
N
N
A
I
L
A
S
---------------
E
I
A
K
E
Y
Q
R
L
---------------------------------------------
5
PsiBlast_PDB
90.27
41%
-103
- C4 -
4EX8
6
?
A:
[17-312]
--------------
Q
L
L
E
V
S
D
E
----
I
A
T
A
L
A
E
R
R
P
V
V
A
L
E
S
S
L
I
T
----
T
D
P
S
S
E
T
-
A
S
L
I
E
K
A
V
-------
R
G
A
G
A
V
P
A
T
I
G
I
A
G
G
K
L
V
V
-----------------------------
G
---
L
T
D
S
L
I
E
R
F
A
S
-
T
K
-
G
I
P
K
I
S
--------
A
R
D
------
I
G
G
A
L
A
G
G
G
L
G
A
T
T
V
A
G
T
I
V
I
A
E
R
A
G
I
Q
-----
V
F
T
T
A
-
G
I
G
G
V
H
R
R
G
E
D
T
L
D
I
S
P
D
-------------
L
L
Q
F
R
K
T
K
--------
M
T
V
V
S
G
G
A
K
-----
S
I
L
D
H
R
L
T
A
E
Y
L
E
T
A
G
V
P
V
Y
G
Y
R
T
---
D
K
L
A
A
F
V
V
R
E
A
--
D
V
P
V
T
--
R
M
D
D
L
-------
H
T
A
A
R
A
A
E
A
H
W
Q
-
V
N
G
-----
P
----
G
T
-----
V
L
L
T
S
P
I
D
E
Q
D
A
V
D
-
E
A
I
V
E
-
A
A
I
A
E
A
L
A
Q
C
D
Q
E
G
I
V
G
N
A
V
S
P
Y
L
M
K
A
L
A
R
A
S
G
-
G
M
L
P
K
A
--------
G
R
S
L
-----
L
L
S
T
A
R
V
A
G
---------------
E
F
S
A
A
L
S
A
V
---------------------------------------------
6
PsiBlast_PDB
90.04
41%
-103
- C4 -
4EX9
5
?
A:
[17-312]
--------------
Q
L
L
E
V
S
D
E
----
I
A
T
A
L
A
E
R
R
P
V
V
A
L
E
S
S
L
I
T
----
T
D
P
S
S
E
T
-
A
S
L
I
E
K
A
V
-------
R
G
A
G
A
V
P
A
T
I
G
I
A
G
G
K
L
V
V
-----------------------------
G
---
L
T
D
S
L
I
E
R
F
A
S
-
T
K
-
G
I
P
K
I
S
--------
A
R
D
------
I
G
G
A
L
A
G
G
G
L
G
A
T
T
V
A
G
T
I
V
I
A
E
R
A
G
I
Q
-----
V
F
T
T
A
-
G
I
G
G
V
H
R
R
G
E
D
T
L
D
I
S
P
D
-------------
L
L
Q
F
R
K
T
K
--------
M
T
V
V
S
G
G
A
K
-----
S
I
L
D
H
R
L
T
A
E
Y
L
E
T
A
G
V
P
V
Y
G
Y
R
T
---
D
K
L
A
A
F
V
V
R
E
A
--
D
V
P
V
T
--
R
M
D
D
L
-------
H
T
A
A
R
A
A
E
A
H
W
Q
-
V
N
G
-----
P
----
G
T
-----
V
L
L
T
S
P
I
D
E
Q
D
A
V
D
-
E
A
I
V
E
-
A
A
I
A
E
A
L
A
Q
C
D
Q
E
G
I
V
G
N
A
V
S
P
Y
L
M
K
A
L
A
R
A
S
G
-
G
M
L
P
K
A
--------
G
R
S
L
-----
L
L
S
T
A
R
V
A
G
---------------
E
F
S
A
A
L
S
A
V
---------------------------------------------
25
HHSearch
80.18
35%
-96
- C4 -
1VKM
4
PSUG_THEMA
A:
[14-296]
---------------------
I
----
I
E
S
R
I
E
K
G
K
P
V
V
G
M
E
T
T
V
F
V
H
G
L
P
R
K
E
A
I
E
L
-
F
R
R
A
K
E
I
S
-------
R
E
K
G
F
Q
L
A
V
I
G
I
L
K
G
K
I
V
A
-----------------------------
G
---
M
S
E
E
E
L
E
A
M
M
R
-
E
--
G
A
D
K
V
G
--------
T
R
E
------
I
P
I
V
V
A
E
G
K
N
A
A
T
T
V
S
A
T
I
F
L
S
R
R
I
G
I
E
-----
V
V
V
T
G
-
G
T
G
G
V
H
P
G
---
R
V
D
V
S
Q
D
-------------
L
T
E
M
S
S
S
R
--------
A
V
L
V
S
S
G
I
K
-----
S
I
L
D
V
E
A
T
F
E
M
L
E
T
L
E
I
P
L
V
G
F
R
T
---
N
E
F
P
L
F
F
S
R
K
S
--
G
R
R
V
P
--
R
I
E
N
V
-------
E
E
V
L
K
I
Y
E
S
M
K
E
-
M
E
L
-----
E
----
K
T
-----
L
M
V
L
N
P
V
P
E
E
Y
E
I
P
-
H
D
E
I
E
-
R
L
L
E
K
-----
I
E
L
E
V
E
G
K
E
V
T
P
F
L
L
K
K
L
V
E
M
T
N
-
G
R
T
L
K
A
--------
N
L
A
L
-----
L
E
E
N
V
K
L
A
G
---------------
E
I
A
V
K
L
K
R
----------------------------------------------
7
PsiBlast_PDB
78.98
36%
-95
- C4 -
1VKM
4
PSUG_THEMA
A:
[21-296]
--------------------------------
K
G
K
P
V
V
G
M
E
T
T
V
F
V
H
G
L
P
R
K
E
A
I
E
L
-
F
R
R
A
K
E
I
S
-------
R
E
K
G
F
Q
L
A
V
I
G
I
L
K
G
K
I
V
A
-----------------------------
G
---
M
S
E
E
E
L
E
A
-
M
M
-
R
E
-
G
A
D
K
V
G
--------
T
R
E
------
I
P
I
V
V
A
E
G
K
N
A
A
T
T
V
S
A
T
I
F
L
S
R
R
I
G
I
E
-----
V
V
V
T
G
-
G
T
G
G
V
H
P
G
---
R
V
D
V
S
Q
D
-------------
L
T
E
M
S
S
S
R
--------
A
V
L
V
S
S
G
I
K
-----
S
I
L
D
V
E
A
T
F
E
M
L
E
T
L
E
I
P
L
V
G
F
R
T
---
N
E
F
P
L
F
F
S
R
K
S
--
G
R
R
V
P
--
R
I
E
N
V
-------
E
E
V
L
K
I
Y
E
S
M
K
E
-
M
E
L
-----
E
----
K
T
-----
L
M
V
L
N
P
V
P
E
E
Y
E
I
P
-----
H
-
D
E
I
E
R
L
L
-
E
K
I
E
L
E
V
E
G
K
E
V
T
P
F
L
L
K
K
L
V
E
M
T
N
-
G
R
T
L
K
A
--------
N
L
A
L
-----
L
E
E
N
V
K
L
A
G
---------------
E
I
A
V
K
L
K
R
----------------------------------------------
51
Fugue
47.16
19%
-22
* C5 *
4N5H
5
?
X:
[1-315]
--------MADE
E
A
M
L
A
K
V
Q
A
S
----
W
A
Q
T
A
A
R
D
K
A
R
Y
A
D
E
R
V
P
E
D
V
H
W
E
T
E
Y
R
Y
E
Q
-
S
A
D
P
Q
Q
T
L
NLYYPAK
R
R
N
A
T
M
P
T
V
I
D
I
H
G
G
G
W
F
Y
-----------------------------
G
DRN
L
N
R
N
Y
C
R
Y
L
A
S
-
Q
G
Y
A
V
M
G
M
G
--------
Y
R
L
------
L
P
D
V
D
L
R
G
Q
I
Q
D
I
F
A
S
L
R
W
L
S
H
F
G
P
Q
R
G
FDLDH
V
L
L
T
G
D
S
A
G
G
H
L
A
S
L
V
A
C
I
Q
Q
S
A
E
-------------
L
Q
E
L
F
G
V
S
RVNFNFTL
V
A
L
V
C
P
V
A
E
-------------
P
S
K
L
P
E
A
A
----
G
D
M
S
---
D
M
A
A
F
Y
L
D
K
L
S
GG
D
Q
A
L
V
D
-
H
L
N
F
S
-------
Q
V
V
K
G
L
D
L
P
P
---
F
M
L
-----
I
----
G
G
QNDSF
Y
L
Q
S
Q
A
L
L
K
V
F
D
A
N
-
H
--
V
T
-
Y
T
T
K
L
W
P
A
S
A
G
P
H
L
K
H
V
F
N
V
Q
H
W
E
W
---------
P
E
S
I
E
T
--------
N
L
E
M
-----
L
R
T
F
D
A
L
S
K
---------------
Q
Q
D
Q
A
E
E
N
E
---------------------------------------------
47
Fugue
42.15
21%
-45
- C5 -
4C2E
-
CTPB_BACSU
A:
[2-436]
AD
S
E
R
D
K
A
M
D
K
I
E
K
A
Y
E
L
I
S
N
E
YVEK
V
D
R
E
K
L
L
E
G
A
I
Q
G
M
L
S
T
L
N
D
P
Y
S
V
Y
M
D
K
Q
T
A
-
K
Q
F
S
D
S
L
D
-------
S
S
F
E
G
I
G
A
E
V
G
M
E
D
G
K
I
I
I
VSPFKKS
P
A
E
K
A
GLKPNDEIISINGESMA
G
---
K
D
L
N
H
A
V
L
K
I
R
-
G
K
-
K
G
S
S
V
S
M
K
I
Q
R
P
GT
K
K
Q
------
L
S
F
R
I
K
R
A
E
I
P
L
E
T
V
F
A
S
E
K
K
V
Q
G
H
S
V
G
-----
Y
I
A
I
S
-
T
F
S
E
-----
H
T
T
E
D
F
A
K
A
-------------
L
R
E
L
E
K
K
E
--------
I
E
G
L
V
I
D
V
R
GNPGG
Y
I
Q
S
V
E
E
I
L
K
H
F
V
T
K
D
Q
P
Y
I
Q
I
A
E
RNG
D
K
K
R
Y
F
S
T
L
T
H
--
K
K
A
Y
P
V
-
N
V
I
T
D
KGSA
A
A
S
E
I
L
A
G
A
L
K
E
A
G
H
-
Y
D
V
V
G
DTS
F
----
G
K
-----
G
T
V
Q
Q
A
V
P
M
G
D
G
S
N
-
I
K
L
T
L
-
Y
K
W
L
T
P
----
N
G
N
W
I
H
K
K
G
I
E
P
T
I
A
I
K
Q
P
D
Y
F
S
-
A
G
P
L
Q
L
K
E
P
L
K
V
DM
N
N
E
D
-----
V
K
H
A
Q
V
L
L
K
G
L
SFDPGREDGYFS
K
D
M
K
K
A
V
M
A
F
Q
D
Q
N
KLNKTGIID
T
R
T
A
E
T
L
N
Q
Q
I
E
K
K
K
S
DEKND
L
Q
L
Q
T
A
L
K
S
L
F
46
Fugue
41.02
18%
-41
- C1 -
3G8Q
2
CDAT8_METKA
A:
[1-278]
------------
M
K
V
S
L
A
-
G
Q
T
----
V
D
V
K
K
I
L
N
E
I
P
K
R
T
V
T
A
A
L
L
E
G
G
E
I
V
A
V
E
E
A
D
D
E
H
A
E
R
K
L
-------
V
R
R
H
D
V
E
G
K
V
V
F
V
T
A
R
P
------------------------------------------
C
L
Y
C
-
A
R
-
E
L
A
E
A
G
--------
V
A
G
------
V
V
Y
L
G
R
G
R
G
L
G
P
Y
Y
L
A
R
S
G
V
--
E
V
V
E
V
H
-----
P
D
E
P
L
-
G
Y
D
P
V
D
R
-----
L
D
V
L
L
T
-------------
F
G
G
N
P
Y
L
T
--------
E
E
D
V
A
A
R
V
Y
-----
C
L
L
T
G
R
--------------
G
F
D
A
---
D
I
A
P
A
P
E
N
L
S
G
--
R
V
E
I
M
V
-
T
R
G
D
P
-------
D
E
A
V
E
L
L
K
E
E
L
P
V
F
R
I
-----
R
R
F
LI
S
G
-----
E
F
D
R
D
E
L
R
E
R
I
L
E
D
I
E
P
R
I
L
-
D
P
F
A
V
R
A
R
I
A
R
A
G
A
F
S
S
S
R
E
A
E
V
F
I
G
D
V
L
T
S
V
G
R
E
V
N
L
N
D
--------
P
R
T
V
-----
V
T
V
D
V
L
-
G
P
---------------
R
V
S
V
G
V
E
K
R
---------------------------------------------
50
Fugue
38.28
15%
-18
- C5 -
4BVA
3
CRYM_MOUSE
A:
[24-334]
----------K
R
A
P
A
F
L
S
A
E
E
V
----
Q
D
H
L
R
S
S
S
L
L
I
P
P
L
E
A
A
L
A
N
F
S
K
G
P
D
G
G
V
M
Q
-
P
V
R
T
V
V
P
V
-------
A
K
H
R
G
F
L
G
V
M
P
A
Y
S
A
A
-
E
D
-----------------------------
A
---
L
T
T
K
L
V
T
F
Y
---
E
S
-
H
Q
A
S
V
L
--------
L
F
D
PSNGSL
L
A
V
M
D
G
N
V
I
T
A
K
R
T
A
A
V
S
A
I
A
T
K
L
L
K
P
P
-----
G
S
D
V
L
-
C
I
L
G
A
G
V
Q
A
Y
S
H
Y
E
I
F
T
E
-------------
Q
F
S
F
--
K
E
--------
V
R
M
W
N
R
T
R
E
-----
N
A
E
K
F
A
S
T
V
Q
----
G
D
V
R
V
C
S
S
V
Q
---
E
A
V
T
-----
G
A
--
D
V
I
I
T
V
T
M
A
T
E
P
-------
I
L
F
G
E
W
V
K
P
G
A
H
-
I
N
A
-----
V
----
G
A
-----
S
R
P
D
W
R
E
L
D
D
E
L
M
R
-
Q
A
V
L
Y
V
D
S
R
E
A
A
L
K
E
S
G
D
V
L
L
S
G
A
D
I
-
F
A
E
L
G
E
V
I
S
G
A
K
-
P
A
H
C
E
K
--------
T
T
V
F
K
S
LGM
A
V
E
D
L
V
A
A
K
---------------
L
V
Y
D
S
W
S
S
G
---------------------------------------------
12
PsiBlast_PDB
35.44
20%
-69
- C4 -
4PZ0
5
?
A:
[18-123]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
G
V
G
-----
F
F
T
S
G
-
G
E
G
A
K
E
M
G
D
K
L
G
V
Q
V
K
Y
D
G
P
SEAS
V
S
G
Q
V
K
Y
I
N
N
F
I
N
Q
N
--------
Y
D
A
L
M
V
S
S
T
-----
S
V
D
G
L
S
Q
S
L
Q
R
A
K
K
K
G
M
T
V
L
T
W
D
S
---
D
V
N
P
------
K
--
D
R
S
F
Y
I
-
S
Q
G
T
P
-------
D
Q
L
A
N
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------