@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0098: (2015-11-28 )
MVTKVEEIRSYLIASIQNGKLAPGDRLPSIRQLANQFSCNKDTVQRVLMELRFDNYVYAKPRSGYYVFDSHEEEVEEGVSLPNSEIANIAYDDFRLCLNETLIGREDYLFNYYYRQEGLLDLSKAVAKLMEETGVYVPLDDIVITAGTQQALFILTQVTFPNRKSRVLIEEPTYPRMIELIKTQNLPYETISRGTHGIDFQRLEEIFQTQSIKFFYVIPRMHNPLGTSYNPVEMKRLIEMAEKYDVYIVEDDYMSDFASQSPLHYYDTHGRVIYLKSFSKAIFPALRLAAICLPQALKSTFMAYKKLMDYDTNLILQKALALYIENGLYGKNSQYLKYRYQKDLANSKSILADQPNLPPYSLHHDSVLFDCSKLDNFKILRQYGDTLENYFCQKSHQSLLQVKNDSCLKQFLGSL
Atome Classification :
(20 SA)
-----------.........10........20........30........40........50........60......--..70........80..--.-------------------.....90........100.......110.....------------------..120.......130-.-...-...140.--........150.......160.......170.......180.......190.......200.....-------..-------210.......220.......230--.......240...-....250...----..----.----.260--.----.---......---.270.......280.......290.......300.......310--........320.......330........340.......350....---...360.......370..------..---...380........390.......400.......410...--------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MVT
K
V
E
E
I
R
S
Y
L
I
A
S
IQNGKLAPGDRL
P
S
I
R
Q
L
A
N
QFSC
N
K
D
T
V
Q
R
V
L
M
E
L
RFDN
Y
V
Y
AKPRS
G
Y
Y
V
--FDS
H
E
E
E
V
E
EGVSLPN--
S
-------------------
E
I
A
N
I
A
Y
D
D
F
R
L
C
L
N
E
T
LIGRED
Y
L
F
N
Y
Y
Y
R
QE------------------
G
L
L
D
L
S
K
A
V
A
K
L
M
E
E-T-G
V
Y
-
V
PLD--
D
--
I
V
I
TAGT
Q
Q
A
L
F
I
L
T
Q
VTFPNRK
S
R
V
L
I
EEPT
Y
P
R
M
I
E
L
I
KTQNL
P
Y
E
T
ISRGTHGI
D
F
Q
R
L
E
E
I
F
-------QT-------QS
I
K
F
F
Y
V
IPRMHNPLGTSY
N
P
V
--
E
M
K
R
L
I
E
M
A
E
KY
D
-
V
Y
I
VE
D
D
Y
M
S
----
D
F
----A----SQ----S----P---
L
H
Y
YDT---H
G
R
V
I
Y
L
K
S
F
S
K
A
I
F
P
A
L
R
L
A
A
I
C
L
P
Q
A
L
K
S
T
F
M
A
Y
K
K
L
MDYD---
T
N
L
I
L
Q
K
A
L
A
L
Y
I
ENGLYG-KNSQ
Y
L
K
Y
R
Y
Q
K
DLANSKSILADQPN---LPPYSLHHD
S
V
L
F
D
C
SKL------D
N
---
F
K
I
L
-
R
Q
Y
G
D
T
L
E
N
Y
F
C
Q
K
S
H
Q
S
L
L
Q
VK
N
D
S
C
L
K
Q
F
L
GSL--------------------
6
PsiBlast_PDB
83.52
27%
-115
- C2 -
4MGR
3
GABR_BACSU
A:
[18-373]
----------------
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
D
M
F
S
A
E
E
H
P
P
F
A
L
P
D
DL
K
-------------------
E
I
-
H
I
D
Q
S
D
W
-
I
S
F
S
H
M
S
S
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
YRTLGDMSHPQ
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
-
T
R
G
V
K
-
C
R
P
E
--
Q
--
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
L
-
L
P
-
K
E
A
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
M
S
---
I
A
E
I
T
-------
R
Q
-------
Q
P
-
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
-
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
-
R
Y
I
I
E
D
D
Y
D
S
----
E
F
----
T
YDVD
S
I
----
P
----
A
---
L
Q
S
L
D
R
---
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
---
L
R
A
Y
K
Q
-
R
G
Y
D
LQT
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
---
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
------
D
T
---
R
R
T
E
-
Q
D
I
L
S
H
A
A
G
L
Q
L
E
I
F
G
M
S
R
F
N
L
K
E
N
K
R
Q
T
G
R
P
A
L
I
--------------------
13
PsiBlast_PDB
83.34
27%
-118
- C2 -
4N0B
2
GABR_BACSU
A:
[18-373]
----------------
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
D
M
F
S
A
E
E
H
P
P
F
A
L
P
D
DL
K
-------------------
E
I
-
H
I
D
Q
S
D
W
-
I
S
F
S
H
M
S
S
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
YRTLGDMSHPQ
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
-
T
R
G
V
K
-
C
R
P
E
--
Q
--
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
L
-
L
P
-
K
E
A
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
M
S
---
I
A
E
I
T
-------
R
Q
-------
Q
P
-
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
-
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
-
R
Y
I
I
E
D
D
Y
D
S
----
E
F
----
T
YDVD
S
I
----
P
----
A
---
L
Q
S
L
D
R
---
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
---
L
R
A
Y
K
Q
-
R
G
Y
D
LQT
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
---
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
------
D
T
---
R
R
T
E
-
Q
D
I
L
S
H
A
A
G
L
Q
L
E
I
F
G
M
S
R
F
N
L
K
E
T
G
R
P
A
L
I
I
G
F
A
--------------------
82
Fugue
82.94
23%
-99
- C3 -
4MGR
3
GABR_BACSU
A:
[2-469]
D
I
T
I
T
L
DRSEQ
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
D
M
F
S
A
E
E
H
P
P
F
A
L
P
D
--
D
LKE
I
H
I
D
Q
S
DWISFSHMSS
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
R
T
L
G
D
M
S
H
P
Q
-------------------
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
-
T
R
G
V
K
-
C
R
P
E
--
Q
--
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
L
--
L
P
K
E
A
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
M
S
---
I
A
E
I
T
-------
R
Q
-------
Q
P
-
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
--
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
R
Y
I
I
E
D
D
Y
D
S
----
E
F
TYDV
D
----
S
I
----
P
----
A
---
L
Q
S
L
D
R
---
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
L
R
A
Y
K
Q
R
G
Y
D
L
Q
T
----
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
---
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
------
D
T
RRT
E
Q
D
I
-
L
S
H
A
A
G
L
Q
L
E
I
F
G
M
S
R
F
N
L
K
E
N
K
R
Q
T
G
R
P
A
L
I
I
G
F
ARLKEED
I
Q
E
G
V
Q
R
L
FKAVY
66
HHSearch
72.31
21%
-95
- C3 -
2ZC0
4
?
A:
[37-364]
-----------------------------------------------------------------------------------------
I
S
L
A
A
G
D
--
P
-------------------
D
P
E
L
I
P
R
A
V
L
G
E
I
A
K
E
V
L
E
K
E
P
-
K
S
V
-
M
Y
T
P
A
N
------------------
G
I
P
E
L
R
E
E
L
A
A
F
L
K
K
Y
D
-
H
L
E
-
V
S
P
E
--
N
--
I
V
I
T
I
G
G
T
G
A
L
D
L
L
G
R
V
L
I
-
D
P
G
D
V
V
I
T
E
N
P
S
Y
I
N
T
L
L
A
F
E
Q
L
G
A
K
I
E
G
V
P
V
D
N
D
G
M
R
V
D
L
L
E
E
K
I
-------
K
E
L
K
A
K
G--
Q
K
V
K
L
I
Y
T
I
P
T
G
Q
N
P
M
G
V
T
M
S
M
E
--
R
R
K
A
L
L
E
I
A
S
K
Y
D
-
L
L
I
I
E
D
T
A
Y
N
----
F
M
----
R
----
Y
E
G---
G
DIV-
P
---
L
K
A
L
D
N
---
E
G
R
V
I
V
A
G
T
L
S
K
V
L
G
T
G
F
R
I
G
W
I
I
A
E
G
E
I
L
K
K
V
L
M
Q
K
Q
P
I
D
F
C
---
A
P
A
I
S
Q
Y
I
A
L
E
Y
L
K
R
G
Y
F
E
K
Y
H
L
E
G
A
L
L
G
Y
K
E
K
R
D
I
M
L
K
A
L
E
N
H
L
P
---
N
A
E
F
T
K
P
I
A
G
M
F
V
M
F
F
L
P
EGAD
G
I
S
F
---
A
N
E
L
M
E
R
E
G
V
V
V
V
P
G
K
P
F
Y
T
D
E
S
G
K
N
A
I
R
L
N
F
S
R
P
S
K
E
E
I
--------------------
64
HHSearch
71.38
23%
-97
- C3 -
3AOW
4
?
A:
[75-405]
------------------------------------------------------------------------------------
T
S
D
I
-
I
S
L
A
G
G
L
--
P
-------------------
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
M
E
K
Y
A
D
K
A
L
Q
-
Y
G
T
T
K
------------------
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
Y
-
G
I
S
-
Q
-
D
N
--
D
--
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
-
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
-------
K
E
L
K
S
Q
G--
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
--
R
R
K
Y
L
L
E
L
A
S
E
Y
D
-
F
I
V
V
E
D
D
P
Y
G
----
E
L
----
R
----
Y
S
GNPE
K
----
K
---
I
K
A
L
D
N
---
E
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
---
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E--
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
DGIDSK
K
M
---
L
E
R
A
-
I
K
K
G
V
A
Y
V
P
G
E
A
F
Y
A
H
R
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
--------------------
68
HHSearch
68.40
22%
-95
- C3 -
2ZYJ
2
LYSN_THET2
A:
[35-353]
-----------------------------------------------------------------------------------------
L
S
F
A
G
G
L
--
P
-------------------
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
L
R
E
K
G
E
V
A
L
Q
-
Y
S
P
T
E
------------------
G
Y
A
P
L
R
A
F
V
A
E
W
I
G
--------
V
R
P
E
--
E
--
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
F
L
-
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
P
D
L
D
A
L
E
E
V
L
-------
K
R
-------
E
R
P
R
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
--
A
R
K
R
L
L
Q
M
V
M
E
R
G
-
L
V
V
V
E
D
D
A
Y
R
----
E
L
----
Y
----
F
G
----
E
ARLP
S
---
L
F
E
L
A
R
E
A
G
Y
P
G
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
V
Q
A
K
Q
G
A
D
L
H
---
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
K--
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
KGLS
A
E
G
L
---
F
R
R
A
-
L
E
E
N
V
A
F
V
P
G
G
P
F
F
A
N
G
G
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
--------------------
14
PsiBlast_PDB
68.00
30%
-125
- C3 -
1WST
1
?
A:
[79-302]
--------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
T
T
K
------------------
G
F
T
P
L
R
L
A
L
A
R
W
M
E
K
-
R
--
Y
D
-
I
P
M
S
K
V
E
--
I
M
T
V
A
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
P
I
V
V
E
A
P
T
Y
L
A
A
I
Q
A
F
K
Y
Y
D
P
E
F
I
S
I
P
L
D
D
K
G
M
R
V
D
L
L
E
E
K
L
E
E
L
R
K
--
Q
G
-------
K
R
V
K
I
V
Y
T
V
S
T
F
Q
N
P
A
G
V
T
M
S
V
D
--
R
R
K
K
L
L
E
L
A
N
E
Y
D
-
F
L
I
V
E
D
G
P
Y
S
----
E
L
RYSG
E
----
P
T
----
P
----
P
---
I
K
H
F
D
D
---
Y
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
V
A
A
H
P
H
L
I
R
K
M
E
I
A
K
Q
S
I
D
L
C
---
T
N
T
F
G
Q
A
I
A
W
K
Y
V
E
N
G
Y
L
D
-
E
H
I
P
K
I
I
E
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
Y
M
P
---
E
G
V
E
W
T
K
P
E
G
G
M
F
V
R
V
T
L
------
P
E
---
G
I
D
T
-
K
L
M
M
E
R
A
V
A
K
G
V
A
Y
V
P
G
E
A
F
F
V
H
R
D
K
K
N
T
M
R
L
N
F
T
--------------------
7
PsiBlast_PDB
66.21
31%
-135
- C3 -
3AOV
1
?
A:
[141-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
D
--
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
E
L
K
S
--
Q
G
-------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
--
R
R
K
Y
L
L
E
L
A
S
E
Y
D
-
F
I
V
V
E
D
D
P
Y
G
----
E
L
----
R
Y---
S
G
----
N
----
P
EKK
I
K
A
L
D
N
---
E
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
---
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
---
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
------
P
D
---
G
I
D
S
-
K
K
M
L
E
R
A
I
K
K
G
V
A
Y
V
P
G
E
A
F
Y
A
H
R
D
V
K
N
T
M
R
L
N
F
T
--------------------
63
HHSearch
66.00
21%
-102
* C3 *
1VP4
15
?
A:
[46-378]
-----------------------------------------------------------------------------------------
I
S
F
G
G
G
V
--
P
-------------------
D
P
E
T
F
P
R
K
E
L
A
E
I
A
K
E
I
I
E
K
E
Y
H
Y
T
L
Q
-
Y
S
T
T
E
------------------
G
D
P
V
L
K
Q
Q
I
L
K
L
L
E
R
M
Y
-
G
I
T
G
L
D
E
D
--
N
--
L
I
F
T
V
G
S
Q
Q
A
L
D
L
I
G
K
L
F
L
-
D
D
E
S
Y
C
V
L
D
D
P
A
Y
L
G
A
I
N
A
F
R
Q
Y
L
A
N
F
V
V
V
P
L
E
D
D
G
M
D
L
N
V
L
E
R
K
L
-------
S
E
F
D
K
N
GKI
K
Q
V
K
F
I
Y
V
V
S
N
F
H
N
P
A
G
V
T
T
S
L
E
--
K
R
K
A
L
V
E
I
A
E
K
Y
D
-
L
F
I
V
E
D
D
P
Y
G
----
A
L
----
R
----
Y
E
G
---
E
T
V
D-
P
---
I
F
K
I
G
G
---
P
E
R
V
V
L
L
N
T
F
S
K
V
L
A
P
G
L
R
I
G
M
V
A
G
S
K
E
F
I
R
K
I
V
Q
A
K
Q
S
A
D
L
C
---
S
P
A
I
T
H
R
L
A
A
R
Y
L
E
R
Y
D
L
L
-
E
Q
L
K
P
T
I
E
L
Y
R
R
K
R
T
V
M
L
N
A
L
E
E
Y
F
S
DIP
G
V
K
W
V
K
S
E
G
G
L
F
I
W
L
T
L
P
EGFDTW
E
M
---
F
E
Y
A
-
K
R
K
K
V
F
Y
V
P
G
R
V
F
K
V
Y
D
E
P
S
P
S
M
R
L
S
F
C
L
P
P
D
E
K
I
--------------------
36
PsiBlast_CBE
65.78
31%
-132
- C3 -
3AOV
2
?
C:
[141-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
D
--
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
KELKS--
Q
G
-------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
--
R
R
K
Y
L
L
E
L
A
S
E
Y
D
-
F
I
V
V
E
D
D
P
Y
G
----
E
L
----
R
Y---
S
G
----
N
----
P
EKK
I
K
A
L
D
N
---
E
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
---
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
---
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
------
P
D
---
G
I
D
S
-
K
K
M
L
E
R
A
I
K
K
G
V
A
Y
V
P
G
E
A
F
Y
A
H
R
D
V
K
N
T
M
R
L
N
F
T
--------------------
33
PsiBlast_CBE
65.53
31%
-132
- C3 -
3AV7
4
?
C:
[141-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
D
--
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
KELKS--
Q
G
-------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
--
R
R
K
Y
L
L
E
L
A
S
E
Y
D
-
F
I
V
V
E
D
D
P
Y
G
----
E
L
----
R
Y---
S
G
----
N
----
P
EKK
I
K
A
L
D
N
---
E
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
---
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
---
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
------
P
D
---
G
I
D
S
-
K
K
M
L
E
R
A
I
K
K
G
V
A
Y
V
P
G
E
A
F
Y
A
H
R
D
V
K
N
T
M
R
L
N
F
T
--------------------
10
PsiBlast_PDB
65.48
31%
-132
- C3 -
3AV7
5
?
A:
[141-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
D
--
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
E
L
K
S
--
Q
G
-------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
--
R
R
K
Y
L
L
E
L
A
S
E
Y
D
-
F
I
V
V
E
D
D
P
Y
G
----
E
L
----
R
Y---
S
G
----
N
----
P
E
K
K
I
K
A
L
D
N
---
E
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
---
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
---
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
------
P
D
---
G
I
D
S
-
K
K
M
L
E
R
A
I
K
K
G
V
A
Y
V
P
G
E
A
F
Y
A
H
R
D
V
K
N
T
M
R
L
N
F
T
--------------------
15
PsiBlast_PDB
65.23
26%
-122
- C3 -
1VP4
12
?
A:
[57-305]
--------------------------------------------------------------------------------------------
T
F
P
R
--
K
-------------------
E
L
A
E
I
A
---------
K
E
I
I
E
K
E
Y
H
Y
T
L
Q
Y
S
T
T
E
------------------
G
D
P
V
L
K
Q
Q
I
L
K
L
L
E
R
-
M
-
Y
G
I
-
T
G
L
D
--
E
DN
L
I
F
T
V
G
S
Q
Q
A
L
D
L
I
G
K
L
-
F
L
D
D
E
S
Y
C
V
L
D
D
P
A
Y
L
G
A
I
N
A
F
R
Q
Y
L
A
N
F
V
V
V
P
L
E
D
D
G
M
D
L
N
V
L
E
R
K
L
S
E
F
D
K
N
G
K
I
-------
K
Q
V
K
F
I
Y
V
V
S
N
F
H
N
P
A
G
V
T
T
S
L
E
--
K
R
K
A
L
V
E
I
A
E
K
Y
D
-
L
F
I
V
E
D
D
P
Y
G
ALRY
E
G
----
E
----
T
V
----
D
----
P
---
I
F
K
I
G
G
---
P
E
R
V
V
L
L
N
T
F
S
K
V
L
A
P
G
L
R
I
G
M
V
A
G
S
K
E
F
I
R
K
I
V
Q
A
K
Q
S
A
D
L
C
---
S
P
A
I
T
H
R
L
A
A
R
Y
L
E
R
Y
D
L
L
-
E
Q
L
K
P
T
I
E
L
Y
R
R
K
R
T
V
M
L
N
A
L
E
E
Y
F
S
---
D
I
P
G
V
K
W
V
K
S
E
G
G
L
F
I
W
L
------
T
L
---
P
E
G
F
-
D
T
W
E
M
F
E
Y
A
K
R
K
K
V
F
Y
V
P
G
R
V
F
K
V
Y
D
E
P
S
P
S
M
R
L
S
--------------------
9
PsiBlast_PDB
65.19
31%
-131
- C3 -
3ATH
3
?
A:
[141-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
D
--
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
E
L
K
S
--
Q
G
-------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
--
R
R
K
Y
L
L
E
L
A
S
E
Y
D
-
F
I
V
V
E
D
D
P
Y
G
----
E
L
----
R
Y---
S
G
----
N
----
P
E
K
K
I
K
A
L
D
N
---
E
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
---
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
---
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
------
P
D
---
G
I
D
S
-
K
K
M
L
E
R
A
I
K
K
G
V
A
Y
V
P
G
E
A
F
Y
A
H
R
D
V
K
N
T
M
R
L
N
F
T
--------------------
8
PsiBlast_PDB
65.13
31%
-133
- C3 -
3AOW
4
?
A:
[141-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
D
--
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
E
L
K
S
--
Q
G
-------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
--
R
R
K
Y
L
L
E
L
A
S
E
Y
D
-
F
I
V
V
E
D
D
P
Y
G
----
E
L
----
R
Y---
S
G
----
N
----
P
EKK
I
K
A
L
D
N
---
E
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
---
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
---
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
------
P
D
---
G
I
D
S
-
K
K
M
L
E
R
A
I
K
K
G
V
A
Y
V
P
G
E
A
F
Y
A
H
R
D
V
K
N
T
M
R
L
N
F
T
--------------------
35
PsiBlast_CBE
65.06
31%
-133
- C3 -
3AOW
4
?
C:
[141-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
D
--
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
KELKS--
Q
G
-------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
--
R
R
K
Y
L
L
E
L
A
S
E
Y
D
-
F
I
V
V
E
D
D
P
Y
G
----
E
L
----
R
Y---
S
G
----
N
----
P
EKK
I
K
A
L
D
N
---
E
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
---
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
---
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
------
P
D
---
G
I
D
S
-
K
K
M
L
E
R
A
I
K
K
G
V
A
Y
V
P
G
E
A
F
Y
A
H
R
D
V
K
N
T
M
R
L
N
F
T
--------------------
12
PsiBlast_PDB
64.89
31%
-134
- C3 -
1X0M
-
?
A:
[121-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
D
--
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
E
L
K
S
--
Q
G
-------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
--
R
R
K
Y
L
L
E
L
A
S
E
Y
D
-
F
I
V
V
E
D
D
P
Y
G
----
E
L
----
R
Y---
S
G
----
N
----
P
E
K
K
I
K
A
L
D
N
---
E
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
---
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
---
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
------
P
D
---
G
I
D
S
-
K
K
M
L
E
R
A
I
K
K
G
V
A
Y
V
P
G
E
A
F
Y
A
H
R
D
V
K
N
T
M
R
L
N
F
T
--------------------
32
PsiBlast_CBE
64.50
31%
-131
- C3 -
3WX9
5
?
C:
[141-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
D
--
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
KELKS--
Q
G
-------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
--
R
R
K
Y
L
L
E
L
A
S
E
Y
D
-
F
I
V
V
E
D
D
P
Y
G
----
E
L
----
R
Y---
S
G
----
N
----
P
EKK
I
K
A
L
D
N
---
E
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
---
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
---
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
------
P
D
---
G
I
D
S
-
K
K
M
L
E
R
A
I
K
K
G
V
A
Y
V
P
G
E
A
F
Y
A
H
R
D
V
K
N
T
M
R
L
N
F
T
--------------------
34
PsiBlast_CBE
64.48
31%
-134
- C3 -
3ATH
3
?
C:
[141-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
D
--
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
KELKS--
Q
G
-------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
--
R
R
K
Y
L
L
E
L
A
S
E
Y
D
-
F
I
V
V
E
D
D
P
Y
G
----
E
L
----
R
Y---
S
G
----
N
----
P
EKK
I
K
A
L
D
N
---
E
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
---
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
---
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
------
P
D
---
G
I
D
S
-
K
K
M
L
E
R
A
I
K
K
G
V
A
Y
V
P
G
E
A
F
Y
A
H
R
D
V
K
N
T
M
R
L
N
F
T
--------------------
11
PsiBlast_PDB
64.16
31%
-135
- C3 -
3WX9
6
?
A:
[141-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
D
--
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
E
L
K
S
--
Q
G
-------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
--
R
R
K
Y
L
L
E
L
A
S
E
Y
D
-
F
I
V
V
E
D
D
P
Y
G
----
E
L
----
R
Y---
S
G
----
N
----
P
EKK
I
K
A
L
D
N
---
E
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
---
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
---
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
------
P
D
---
G
I
D
S
-
K
K
M
L
E
R
A
I
K
K
G
V
A
Y
V
P
G
E
A
F
Y
A
H
R
D
V
K
N
T
M
R
L
N
F
T
--------------------