@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0129: (2015-11-28 )
MSKITTSLFQEMVQAASTRLSKQAEYVNSLNVFPVPDGDTGTNMGMTMENGAKEVSDKPATTVGEVGQILSKGVLMGARGNSGVITSQLFRGFGQSIKDKEELTGQDLAHAFQNGVEVAYKAVMKPVEGTILTVSRGAATAALKKAEETDDAVEVMRATLKGAKRALAKTPEMLPVLKEVGVVDSGGQGLVFIYEGFLSALTGEYIASEDFKATPATMTEMVNAEHHKAVVGHVATEDIKYGYCTEVMVGLKQGPTYVKEFNYEEFQGYLSNLGDSLLVVNDDEIVKVHVHTEDPGLVMQEGLKYGSLVKVKVENMRNQHDAQMQKVEVEETVKETKEYGIIAVVAGDGLAEIFKSQGVDYIISGGQTMNPSTEDIVKAIEKVNARNVIILPNNKNIFMAAQSAADVVDIPAAVVETRTVPQGFTSLLAFDPAKSLETNVADMTNSLSDVISGSVTLAVRDTTIDGLEIHENDILGMVDGKILVSTPDMEKALKDTFDKMIDEDSEIVTIYVGEDGKQALAETLSEYLEETYEDVEVEIHQGDQPVYPYLMSVE
Atome Classification :
(20 SA)
---.........10....------------------....20........30........40........50....-----...--.60........70.---.......80........90........100.......110.....-..120-.-....--..130.......140.......150.......160.......170.-.....------.--180.......190.......200.......210.......220.......230.......240......----.250.......260.......270----.......280.......290.......300.......310.......320.......330.......340......-.350.......-----360---.....---------------------------...370.......380----.---......390.....---..400......----.-----410.......420.........---430...------------------------.-.....440......--.450.......460.......470--------.-----------.-----------....-.-.480.......490.........500.------......510.......520.......530........540.......550..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MS
K
I
T
T
S
L
F
Q
E
M
V
Q
A
------------------
A
S
T
R
L
S
K
Q
A
E
Y
V
NSLN
V
F
PVPDGDTGTNM
G
M
TMENG
A
K
EV-----SDK--PAT
T
V
G
E
V
G
Q
I
L
S
K---G
V
L
MGARGNS
G
V
I
T
S
Q
L
F
R
GF
G
Q
SIK
D
K
E
EL
T
G
Q
D
L
A
H
A
F
QN
G
V
E
-
V
A
Y
K
A
-
V
-MKPV--E
G
T
I
L
T
VSRGA
A
T
A
A
L
KKAEET
D
D
A
V
E
V
M
R
A
T
L
K
G
A
K
R
A
L
AKT
P
E
M
-
L
P
V
L
K
------E--VGVVDSGG
Q
G
L
V
F
I
Y
E
G
F
L
S
A
L
TG
E
Y
IASEDFKAT
P
A
T
M
T
E
M
VN
A
E
H
H
K
A
V
V
G
HVATEDIKY
G
Y
C
T
E
V
M
----
V
GLKQG
P
T
Y
V
K
EF
N
Y
E
E
F
Q
G
Y
L
S
N----LGD
S
L
L
V
VNDD
E
I
V
K
V
H
V
HTEDP
G
L
V
M
Q
EGLKYG
S
L
V
K
V
K
V
E
N
MR
N
Q
H
D
A
Q
M
Q
K
V
E
V
E
E
T
V
K
E
T
KEY
G
I
I
A
V
VAGD-
G
L
A
E
I
F
K
SQGV-----
D
Y
----
I
ISGG---------------------------QTMNP
S
T
E
D
I
V
K
A
I
E
K----V---NAR
N
V
I
I
LPNNK
N
I
---
F
M
AAQSAADVV----D-----I
P
A
A
V
V
ETRTV--
P
Q
G
F
T
S
L
LA---F--D
P
A
------------------------
K
-
S
L
E
T
N
V
A
D
M
T
N
S
L
S
--
D
V
ISG
S
V
T
L
A
V
RDTTID
G
L
E
IHE---------N-----------D-----------
I
L
G
M-V-D
G
K
I
L
V
ST
P
D
M
E
--
K
A
L
K
D
T
F
D
K
M
IDE------DS
E
I
V
T
I
Y
VGED
G
K
Q
A
L
A
E
T
L
S
E
Y
L
E
E
T
-
Y
ED
V
E
V
E
I
HQGDQP
V
Y
P
Y
L
M
SVE
41
Fugue
74.22
16%
-14
- C1 -
4JE5
5
ARO8_YEAST
A:
[5-502]
T
L
P
E
S
K
D
F
S
Y
L
F
S
D
E
T
N
A
RKPSPLKLFQDPNIIFLG
G
G
L
P
L
K
D
Y
F
P
W
D
N
L
S
V
D
S
P
K
P
P
F
P
Q
G
I
G
A
P
I
D
E
Q
N
C
I
K
Y
T
V
N
KDY
A
D
K
--
S
A
N
P
S
N
D
I
P
--
L
S
R
---
A
L
Q
Y
G
--
F
S
A
G
--
Q
P
E
L
L
N
F
I
R
D
H
T
K
I
I
H
D
L
K
Y
K
D
W
D
V
L
A
T
A
G
N
T
-
N
A
W
E
S
-
T
-
L
R
V
F
CN
R
G
D
V
I
L
V
E
A
H
S
F
S
S
S
L
A
S
A
E
A
Q
G
------
V
I
T
F
P
V
P
I
D
A
D
G
I
I
P
E
K
-
L
A
K
V
M
------
E
--
N
W
T
P
G
A
P
K
P
K
L
L
Y
T
------
I
P
T
G
Q
N
P
T
G
T
S
I
A
D
H
R
K
E
A
I
Y
K
I
A
Q
K
Y
-----
D
F
L
I
V
E
D
E
P
Y
Y
F
L
Q
M
N
P
YIKD
L
K
E
R
E
K
A
Q
S
S
P
K
Q
D
H
D
E
F
L
K
S
L
A
N
T
FLS
L
D
T
E
G
R
V
I
R
M
D
S
F
S
K
V
L
A
P
G
T
R
L
G
W
I
T
G
S
--------
S
K
I
L
K
P
Y
L
S
L
H
E
M
T
I
Q
A
P
A
-----------
G
F
T
Q
V
L
V
N
A
-
T
L
S
R
W
G
Q
K
G
Y
L
-----
D
W
----
L
L
G
L
R
---------------------------
H
E
Y
T
L
K
R
D
C
A
I
D
A
L
Y
K
----
Y
----------
L
P
Q
S
D
A
F
---
V
I
N
P
P
I
A
G
M
F
F
----
T
-----
V
N
I
D
A
S
V
H
P
E
F
--
K
T
K
Y
N
S
---------
D
P
Y
------------------------
Q
-
L
E
Q
S
L
Y
H
K
V
V
E
R
G
V
--
L
V
V
P
G
S
W
F
K
S
E
G
E
T
E
--------------------------------------------------------
P
P
Q
P
--
A
E
S
K
E
V
S
N
P
----------
N
I
I
F
F
R
G
T
Y
A
A
V
S
P
E
K
L
T
E
G
L
K
R
L
G
D
T
L
-
Y
E
E
F
G
I
S
----------------
29
HHSearch
71.94
19%
-54
- C4 -
1MGP
1
Y1468_THEMA
A:
[25-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
K
V
K
I
L
V
D
S
T
A
D
-
V
P
F
S
W
M
E
K
Y
D
I
-----
D
S
I
P
L
Y
V
V
W
E
D
G
R
S
E
P
DERE
P
E
E
I
M
N
F
Y
K
R
I
R
E
AG
S
V
P
K
T
S
Q
P
S
V
E
D
F
K
K
R
Y
L
K
Y
---
K
E
E
-
D
Y
D
V
V
L
V
L
T
L
S
S
K
L
SG
T
Y
N
S
A
V
L
A
S
K
E
V
----
D
-----
I
P
V
Y
V
V
D
T
L
L
A
S
G
A
I
P
L
P
A
R
V
A
R
E
M
L
--
E
N
G
------------------------
A
-
T
I
E
E
V
L
K
K
L
D
E
R
M
K
N
K
D
F
K
A
-
I
F
Y
V
S
N
F
D
Y
L
V
K
G
G
R
V
------------LLK
I
R
------
V
-----------
C
L
H
I
-
E
-
N
G
E
L
I
P
Y
R
K
V
R
G
D
K
K
A
I
E
A
L
I
E
K
L
R
E
D
TPEG--
S
K
L
R
V
I
G
V
H
A
D
N
E
--
A
G
V
V
E
L
L
N
T
L
R
K
S
-
Y
E
V
V
D
E
I
I
S
P
M
G
K
V
I
T
T
H
V
G
P
G
T
22
HHSearch
70.49
20%
-21
- C5 -
1UN8
1
DHAK_CITFR
A:
[353-550]
------
S
A
N
A
L
V
A
G
I
V
E
L
------------------
V
T
A
T
L
S
D
L
E
T
H
L
N
A
L
D
A
-
K
V
G
D
G
D
T
G
S
T
F
A
A
A
A
R
E
I
A
S
L
L
-----
H
R
Q
QL
P
L
N
N
L
A
T
L
F
A
L
I
G
E
---
R
L
T
V
V
M
G
G
S
S
G
V
L
M
S
I
F
F
T
A
A
G
Q
K
L
E
Q
-----
G
A
N
V
V
E
A
L
N
T
G
L
A
-
Q
M
K
F
Y
-
G
G
A
D
E
G
--
D
R
T
M
I
D
A
L
Q
P
A
L
T
S
L
L
A
Q
P
-------
K
N
L
Q
A
A
F
D
A
A
Q
A
G
A
E
R
T
C
L
S
S
K
A
N
A
-ES----
L
--
L
G
N
M
D
P
G
A
Q
R
L
A
M
V
F
K
A
L
A
E
S
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
68.69
17%
-56
- C4 -
2DT8
3
?
A:
[1-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
I
T
L
V
T
D
S
T
S
D
-
L
P
Q
D
L
R
G
R
L
G
V
-----
R
V
V
P
L
Y
V
N
L
S
G
A
I
Y
R
D
WEEIT
P
T
E
I
F
Q
K
V
R
E
GAA
F
P
--
T
T
S
Q
P
S
P
E
D
F
A
R
V
Y
R
E
----
A
L
E-
E
A
D
H
V
L
S
L
H
I
S
G
K
L
SG
T
V
Q
S
A
E
L
A
A
Q
E
F
----
P
-----
G
R
V
T
V
V
D
T
Q
A
A
SL
G
V
G
M
M
V
L
R
A
K
E
L
L
--
E
E
G
------------------------
Q
-
S
L
E
A
V
L
A
E
L
E
R
L
R
R
--
D
H
F
V
-
R
F
S
V
A
T
L
E
F
L
K
R
G
G
R
I
G
G
---------
A
QAFLGTLLN
L
K
P
-----------
V
L
T
L
-
K
-
E
G
R
V
E
A
A
G
R
A
R
G
E
K
K
A
R
E
E
I
L
K
A
F
R
A
W
A
EGR--
K
R
I
R
A
Y
F
L
Y
S
G
D
E
--
D
A
V
A
A
L
R
Q
E
V
L
A
S
G
L
P
V
E
E
A
L
V
N
E
L
G
A
V
I
A
S
H
T
G
P
G
T
30
HHSearch
68.08
16%
-50
- C4 -
3JR7
5
?
A:
[18-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
M
S
Y
K
V
I
V
D
S
C
G
E
-
F
T
P
E
M
K
A
D
G
G
F
-----
E
H
V
A
L
G
I
Q
I
E
D
T
Q
W
T
DDDSLK
Q
E
E
L
L
L
K
I
A
E
ST
S
C
A
--
K
T
S
C
P
S
P
E
R
Y
M
E
S
Y
H
C
--------
D
A
E
R
I
Y
V
V
T
L
S
A
E
L
SG
S
Y
N
S
A
V
L
G
K
N
L
Y
----
E
E
E
YGE
K
Q
I
H
V
F
N
S
R
S
A
S
V
G
E
T
L
I
A
L
K
V
Q
Q
C
E
--
K
A
G
------------------------
M
-
T
F
E
E
V
V
E
S
V
E
C
Y
I
E
--
E
Q
H
T
-
Y
F
V
L
E
N
L
D
T
L
R
K
N
G
R
L
T
G
IKSAGALNI
K
-----------
P
-----------
I
M
G
S
T
P
-
Q
G
T
I
C
Q
K
E
K
A
R
G
M
K
K
A
L
V
K
M
A
D
C
V
A
A
D
VVNA--
G
D
K
I
L
A
I
A
H
C
N
C
E
--
E
R
A
K
E
V
Q
R
L
L
K
E
R
-
F
A
V
K
S
S
F
I
V
D
T
S
G
I
S
T
V
Y
A
N
D
G
G
24
HHSearch
64.59
15%
-69
* C4 *
1PZX
1
?
A:
[3-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
I
E
I
I
T
D
S
G
A
D
-
L
P
Q
S
Y
I
R
E
H
R
I
-----
A
F
L
P
L
V
V
H
W
N
G
Q
D
Y
K
DGITIE
P
K
Q
V
Y
D
A
M
R
Q
GHT
V
---
K
T
A
Q
P
S
P
L
A
M
K
E
L
F
L
P
----
Y
A
K
-
E
N
R
P
C
L
Y
I
A
F
S
S
K
L
SG
T
Y
Q
T
A
M
A
V
R
S
E
L
----
L
D
E
Y
PE
F
R
L
T
I
I
D
S
K
C
A
S
L
G
Q
G
L
A
V
M
K
A
V
E
L
A
--
K
Q
N
------------------------
T
-
P
Y
N
L
L
C
E
T
I
E
S
Y
C
R
--
H
M
E
H
-
I
F
T
V
D
N
L
D
Y
L
A
R
G
G
R
I
S
-----------N
I
K
--------
P
-----------
L
L
H
V
-
E
-
D
G
A
L
I
P
L
E
K
W
R
G
R
K
K
V
L
K
R
M
V
E
L
M
G
E
R
GDDL--
Q
K
Q
T
I
G
I
S
H
A
D
D
E
--
E
T
A
L
E
L
K
Q
M
I
E
E
T
-
H
G
C
T
R
F
F
L
S
D
I
G
S
A
I
G
A
H
A
G
P
G
T
25
HHSearch
63.25
16%
-70
- C4 -
3FYS
9
DEGV_BACSU
A:
[34-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
N
I
A
V
V
T
D
S
T
A
Y
-
I
P
K
E
M
R
E
Q
H
Q
I
-----
H
M
I
P
L
Q
V
V
F
R
E
ETYREEIELD
W
K
S
F
Y
E
E
V
K
K
H
NEL
P
--
T
T
S
Q
P
P
I
G
E
L
V
A
L
Y
E
E
----
L
G
K
-
S
Y
D
A
V
I
S
I
H
L
S
S
G
I
SG
T
F
S
S
A
A
A
A
D
S
M
V
----
D
N----
I
D
V
Y
P
F
D
S
E
I
S
C
L
A
Q
G
F
Y
A
L
K
A
A
E
L
I
--
K
N
G
------------------------
A
S
S
P
E
D
I
I
K
E
L
E
E
M
K
K
--
T
V
R
A
-
Y
F
M
V
D
D
L
A
H
L
Q
R
G
G
R
L
S
S
---------
A
Q
A
F
I
GSLLKVK
P
-----------
I
L
H
F
-
D
-
N
K
V
I
V
P
F
E
K
I
R
T
R
K
K
A
I
S
R
I
Y
E
L
L
D
E
D
ASKG--
L
P
M
R
A
A
V
I
H
A
N
R
E
--
E
E
A
A
K
I
I
E
E
L
S
A
K
-
Y
P
H
V
E
F
Y
N
S
Y
F
G
A
V
I
G
T
H
L
G
E
G
A
31
HHSearch
61.81
18%
-67
- C4 -
3NYI
1
?
A:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Y
K
I
V
S
D
S
A
C
D
-
L
S
K
E
Y
L
E
K
H
D
V
-----
T
I
V
P
L
S
V
S
F
D
G
E
T
Y
Y
R
DGVDIT
R
D
E
C
Y
Q
R
M
V
D
D
PK
L
F
P
K
T
S
L
P
S
V
E
S
Y
A
D
V
F
R
S
----
F
V
E
-
Q
G
F
P
V
V
C
F
T
I
T
T
L
F
SG
S
Y
N
S
A
I
N
A
K
S
L
V
L
E
D
Y
P
D----
A
N
I
C
V
I
D
S
K
Q
N
T
V
T
Q
A
L
L
I
D
Q
F
V
R
M
L
--
E
D
G
------------------------
L
-
S
F
E
Q
A
M
S
K
L
D
A
L
M
A
--
S
A
R
I
-
F
F
T
V
G
S
L
D
Y
L
K
M
G
G
R
I
G
K
---------
V
ATAATGKLGVK
P
-----------
V
I
I
M
-
K
-
D
G
D
I
G
L
G
G
I
G
R
N
R
N
K
L
K
N
S
V
L
Q
V
A
K
K
Y
L
D
E
N
NK
D
N
F
I
V
S
V
G
Y
G
Y
D
K
--
E
E
G
F
E
F
M
K
E
V
E
S
T
-
L
D
V
K
L
D
S
E
T
N
V
A
I
G
I
V
S
A
V
H
T
G
P
32
HHSearch
61.22
13%
-58
- C4 -
2G7Z
15
Y1493_STRP1
A:
[4-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
T
I
K
I
V
T
D
S
S
I
T
-
I
E
P
E
L
I
K
A
L
D
I
-----
T
V
V
P
L
S
V
M
I
D
S
K
L
Y
S
DNDLKEEG
H
F
L
S
L
M
K
A
SK
S
L
P
--
K
T
S
Q
P
P
V
G
L
F
A
E
T
Y
E
N
L
---
V
K
K
-
G
V
T
D
I
V
A
I
H
L
S
P
A
L
SG
T
I
E
A
S
R
Q
G
A
E
I
A
----
E
-----
A
P
V
T
V
L
D
S
G
F
T
D
Q
A
M
K
F
Q
V
V
E
A
A
K
M
A
--
K
A
G
------------------------
A
-
S
L
N
E
I
L
A
A
V
Q
A
I
K
S
--
K
T
E
L
-
Y
I
G
V
S
T
L
E
N
L
V
K
G
G
R
I
G
R
VTGL
N
V
---
K
-----------
V
-----------
V
M
A
L
-
K
-
N
D
E
L
K
T
L
V
K
G
R
G
N
K
T
F
T
K
W
L
D
S
Y
L
A
K
N
SHR---
P
I
A
E
I
A
I
S
Y
A
G
E
A
--
S
L
A
L
T
L
K
E
R
I
A
A
Y
-
Y
N
-
H
S
I
S
V
L
E
T
G
S
I
I
Q
T
H
T
G
E
G
A
35
Fugue
60.88
13%
-15
- C5 -
1K4G
2
TGT_ZYMMO
A:
[11-382]
---
R
P
R
F
S
F
S
I
A
A
R
E
G
K
A
------------------
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
-----------
A
A
T
V
K
A
L
-----
K
P
E
--
T
V
R
A
T
G
-
A
D
I
I
L
G
N
---
T
Y
H
L
M
L
R
------------------
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
---------------
W
--
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
-
S
P
E
R
S
-
I
E
I
Q
H
------
L
--
L
G
S
------
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
-----------
A
A
L
----
F
G
I
Q
Q
G
S
V
F
------------------------------------------------------------
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
------------
G
Y
A
V
G
--
G
L
A
V
---
G
E
G
----------------
Q
---------------------------
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
----
D
---
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
---
V
G
A
V
E
R
G
I
D
M
F
----
D
-----
C
V
L
P
T
R
S
G
R
N
-------------------------------------------------------------------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
---------
D
-----------
L
-----------
K
P
L
D
-
S
-
E
C
H
C
A
V
C
Q
K
W
S
R
--
A
Y
I
H
H
L
I
R
A
G
E
I
L
------
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
-
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----------
21
HHSearch
59.59
18%
-28
- C5 -
3CR3
3
DHAL_LACLA
A:
[2-192]
------
L
T
I
D
T
T
I
E
W
L
G
K
------------------
F
N
E
K
I
Q
E
N
K
A
Y
L
S
E
L
D
-
G
P
I
G
D
G
D
H
G
A
N
M
A
R
G
M
S
E
T
M
K
A
L
-----
E
V
S
--
N
F
G
N
V
S
E
I
F
K
K
V
A
M
---
T
L
M
S
K
V
G
G
A
S
G
P
L
Y
G
S
A
F
L
A
M
S
K
T
A
I
E
-----
T
L
D
T
S
E
L
I
Y
A
G
L
E
-
A
I
Q
K
R
G
K
-
A
Q
V
G
--
E
K
T
M
V
D
I
W
S
A
F
L
N
D
L
Q
T
D
S
A
-----------
S
K
D
N
L
E
K
V
V
K
A
S
A
G
L
-
L
A
T
K
G
R
A
S
Y
L
G
E
RS
I
G
H
I
D
P
G
T
Q
S
S
A
Y
L
F
E
T
L
L
E
V
V
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
59.52
13%
-52
- C4 -
3FDJ
5
?
A:
[3-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
L
V
A
D
S
A
C
D
-
I
K
E
L
--
R
G
M
V
F
-----
K
A
V
P
L
T
I
S
T
D
N
E
E
F
C
DDGQLD
I
H
R
M
L
D
I
L
E
K
HK
G
R
S
--
Y
T
A
C
P
G
I
D
A
W
L
E
A
F
G
D
---------
D
D
E
I
F
V
V
T
I
T
A
G
M
SG
T
Y
N
S
A
M
A
A
R
A
V
Y
----
L
E
E
H
P
Q
A
K
V
R
V
I
D
S
K
S
T
G
P
Q
M
R
I
I
L
E
Q
L
Q
Q
M
I
--
E
E
G
------------------------
K
-
K
F
E
E
I
D
G
A
I
D
A
Y
M
Q
--
K
T
R
L
-
F
C
S
L
K
S
L
H
N
L
A
Q
N
G
R
V
S
K
---------
V
V
A
S
A
A
EVLG
I
S
V
-----------
I
G
T
A
S
S
-
H
G
T
L
E
A
I
G
K
C
R
G
D
K
K
L
L
V
K
L
Q
A
L
L
D
D
A
GY----
E
G
G
K
L
R
I
C
H
V
E
N
E
--
A
L
A
D
K
I
A
D
M
I
K
Q
A
-
Y
G
T
T
D
V
C
V
Y
K
A
G
G
L
C
S
Y
Y
A
E
R
G
G
26
HHSearch
59.49
15%
-65
- C4 -
3PL5
1
?
A:
[36-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
K
I
L
T
D
S
T
A
D
-
L
P
E
S
W
T
Q
E
N
D
V
-----
Q
V
L
G
L
T
V
Q
L
D
G
I
T
Y
E
TVGPDRLT
S
R
V
L
L
E
K
I
A
A
G
S
K
P
-
T
T
S
Q
V
N
V
G
Q
F
E
S
Y
F
R
Q
----
S
A
E
-
N
G
Q
E
V
L
Y
I
A
F
S
S
V
L
SG
T
Y
Q
S
A
V
M
A
R
D
I
V
----
L
E
E
Y
PQ
A
S
I
E
I
V
D
T
L
A
A
T
G
G
E
G
Y
L
A
M
L
A
A
Q
A
R
--
E
E
G
------------------------
K
-
S
L
K
E
T
K
E
L
I
L
D
V
G
P
--
R
L
R
T
-
F
F
L
V
D
N
L
Y
H
L
M
R
G
G
R
L
S
-LVN
I
-----
K
-----------
P
-----------
L
L
W
L
-
D
A
S
G
K
L
V
P
I
A
K
L
R
G
R
K
K
G
M
K
E
M
L
K
R
A
T
A
D
V-----
A
H
D
T
A
V
V
A
Y
A
N
D
S
--
E
A
A
E
N
L
K
E
Q
L
L
A
N
-
E
K
I
K
N
V
V
T
L
P
L
G
P
V
I
S
T
H
V
G
P
N
T
33
HHSearch
55.59
18%
-62
- C4 -
3LUP
2
?
A:
[3-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
K
L
A
L
I
T
D
T
S
A
Y
-
L
P
E
A
I
E
N
H
E
D
V
-----
Y
V
L
D
I
P
I
I
I
D
G
KTYIEGQNLT
L
D
Q
Y
Y
D
K
L
A
A
SK
E
L
P
--
K
T
S
Q
P
S
L
A
E
L
D
D
L
L
C
Q
L
---
E
K
E
-
G
Y
T
H
V
L
G
L
F
I
A
A
G
I
SG
F
W
Q
N
I
Q
F
L
I
E
E
H
----
P
N----
L
T
I
A
F
P
D
T
K
I
T
S
A
P
Q
G
N
L
V
R
N
A
L
M
C
S
--
R
E
G
------------------------
M
-
D
F
D
V
I
V
N
K
I
Q
S
Q
I
E
--
K
I
E
G
-
F
I
V
V
N
D
L
N
H
L
V
K
G
G
R
L
S
N
---------
G
-----------
S
AIIGNLLS
I
K
P
V
L
H
F
-
N
E
E
G
K
I
V
V
Y
E
K
V
R
T
E
K
K
A
L
K
R
L
A
E
I
V
K
E
M
T
AD---
G
E
Y
D
I
A
I
I
H
S
R
A
Q
--
D
K
A
E
Q
L
Y
N
L
L
A
K
A
-
G
L
K
D
D
L
E
I
V
S
F
G
G
V
I
A
T
H
L
G
E
G
A
14
PsiBlast_PDB
50.57
26%
-82
- C6 -
2D8A
3
TDH_PYRHO
A:
[188-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
S
G
A
Y
P
V
I
V
S
E
P
S
D
-
F
R
R
E
L
A
K
K
V
G
A
-----
D
Y
----
V
I
---------------------------------
N
P
F
E
E
D
V
V
K
E
V
M
D
----
I
---
T
D
G
N
G
V
------
D
V
---
F
L
E
F
S
G
A
P
K
A
L
----
E
-----
Q
G
L
Q
A
V
----
T
--
P
A
G
R
V
S
L
L
G
---
L
--
Y
P
G
------------------------
K
-
V
T
I
D
F
N
N
L
I
I
F
K
A
L
--
T
I
Y
G
I
T
G
R
H
L
W
E
T
W
Y
T
V
S
R
L
L
Q
S
---------
G
-----------
K
-----------
L
N
L
D
-
P
-
I
I
T
H
K
Y
K
G
F
D
K
Y
--
E
E
A
F
E
L
M
R
A
G
K
T
G
------
K
V
V
F
M
L
----------------------------------------------
15
PsiBlast_PDB
48.35
26%
-87
- C6 -
2DFV
1
TDH_PYRHO
A:
[187-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
S
G
A
Y
P
V
I
V
S
E
P
S
D
-
F
R
R
E
L
A
K
K
V
G
A
-----
D
Y
----
V
I
---------------------------------
N
P
F
E
E
D
V
V
K
E
V
M
D
----
I
---
T
D
G
N
G
V
------
D
V
---
F
L
E
F
S
G
A
P
K
A
L
----
E
-----
Q
G
L
Q
A
V
----
T
--
P
A
G
R
V
S
L
L
G
---
L
--
Y
P
G
------------------------
K
-
V
T
I
D
F
N
N
L
I
I
F
K
A
L
--
T
I
Y
G
I
T
G
R
H
L
W
E
T
W
Y
T
V
S
R
L
L
Q
S
---------
G
-----------
K
-----------
L
N
L
D
-
P
-
I
I
T
H
K
Y
K
G
F
D
K
Y
--
E
E
A
F
E
L
M
R
A
G
K
T
G
------
K
V
V
F
M
L
K
---------------------------------------------
34
HHSearch
48.23
8%
-51
- C4 -
3GDW
-
?
A:
[3-123]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
V
G
V
F
V
L
M
H
G
D
S
T
A
S
S
M
L
K
T
A
Q
E
L
L
GTS
I
G
----
T
A
M
N
----------------------------
M
P
L
T
M
E
V
Q
T
M
Y
E
Q
L
R
N
Q
V
I
T
Q
KES
L
N
N
G
I
L
L
L
T
D
M
G
S
L
---
N
S
F
G
N
M
L
F
E
E
T
----
G
-----
I
R
T
K
A
I
T
M
T
S
T
--
M
I
V
L
E
A
I
R
M
---
A
--
S
V
G
------------------------
R
-
S
L
E
D
I
Y
Q
N
I
Q
L
S
F
E
--
S
V
V
R
E
Q
F
R
S
-------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
43.78
26%
8
- C5 -
2BTD
3
DHAL_ECOLI
A:
[19-133]
----------------------------------------
F
S
T
E
S
E
Y
L
T
G
L
D
R
-
E
I
G
D
A
D
H
G
L
N
----
M
N
R
G
F
S
K
V
-----
V
E
K
L-
P
A
I
A
D
K
D
I
G
F
I
L
K
N
T
G
M
T
L
L
S
S
V
G
G
A
S
G
P
L
F
G
T
F
F
I
R
A
A
Q
A
T
Q
A
R
Q
S
L
T
L
E
E
L
Y
Q
M
F
R
D
G
A
D
G
V
I
S
R
G
-
K
-
A
E
P
G
--
D
K
T
M
C
D
V
W
V
P
V
V
E
S
L
R
Q
S
S
E
Q
N
L
S
V
P
V
A
L
E
A
A
S
S
I
A
E
S
A
A
Q
S
T
I
T
M
-
Q
A
R
K
G
------
R
--
A
S
Y
L
G
E
R
S
I
G
H
Q
D
P
G
A
T
S
V
M
F
M
M
Q
M
L
A
L
A
A
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
43.23
26%
13
- C5 -
3PNL
3
DHAL_ECOLI
B:
[20-134]
----------------------------------------
F
S
T
E
S
E
Y
L
T
G
L
D
R
-
E
I
G
D
A
D
H
G
L
N
----
M
N
R
G
F
S
K
V
-----
V
E
K
L-
P
A
I
A
D
K
D
I
G
F
I
L
K
N
T
G
M
T
L
L
S
S
V
G
G
A
S
G
P
L
F
G
T
F
F
I
R
A
A
Q
A
T
Q
A
R
Q
S
L
T
L
E
E
L
Y
Q
M
F
R
D
G
A
D
G
V
I
S
R
G
-
K
-
A
E
P
G
--
D
K
T
M
C
D
V
W
V
P
V
V
E
S
L
R
Q
S
S
E
Q
N
L
S
V
P
V
A
L
E
A
A
S
S
I
A
E
S
A
A
Q
S
T
I
T
M
-
Q
A
R
K
G
------
R
--
A
S
Y
L
G
E
R
S
I
G
H
Q
D
P
G
A
T
S
V
M
F
M
M
Q
M
L
A
L
A
A
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
42.80
25%
7
- C5 -
1CI8
3
ESTB_BURGA
A:
[232-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
G
Q
P
E
P
V
R
M
R
D
G
I
E
-------
V
P
L
P
E
G
H
-
G
A
A
V
R
F
A
P
S
R
V
FEP--
G
A
----
Y
P
S
G
G
---------------------------
A
G
M
Y
G
S
A
D
D
V
L
R
A
L
E
A
----
I
---
R
A
-
N
P
G
F
L
P
E
T
-------
L
A
D
A
A
R
R
D
Q
A
----
G
-----
V
G
A
---
E
T
R
G
P
--
G
W
G
F
G
Y
L
S
A
---
V
LD
D
P
A
AAGTPQHAG
T
L
Q
W
G
G
VY
G
H
S
W
F
V
D
R
-
A
L
G
L
S
V
L
L
L
T
N
T
A
Y
--
E
G
M
S
G
P
L
T
I
A
L
R
D
A
V
Y
A
-----------------------------------------------------------------------------------------------------------------------------------