@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu10120: (2016-06-15 )
MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEKYGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQPIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGPSKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQADYRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARSKGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLKKLTAFVHEYSQNKKMGQYS
Atome Classification :
(23 SA)
.........10........20........30........40.-.-.....-.-50........60........70........80........90........100.......110.-....-.-.---120....---...130...-.-.--..140.......150....------.------.--.---160.......-170.......180.......190.......200.......210.......220---........230....-----.-------.---.-240.......250.......260.......270...-..-..280........290...-....300.......310--........320.......330.......340.......350.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSK
R
E
T
F
N
E
T
F
L
K
A
ARGEKADHTP
V
W
Y
M
R
QAGRS
Q
P
E
Y
R
K
L
K
-
E
-KYG
L
F
-
E
-ITHQ
P
E
L
C
A
Y
V
T
RL
P
V
E
Q
YGV
D
A
A
I
L
Y
K
D
I
MTPLPSI
G
V
D
V
E
IKNGI
G
P
V
I
D
Q
P
I
R
S
L
A
D
I
E
K
L-GQID-P-E---QD
V
P
Y
V
L
---
E
T
I
K
L
L
V
NE-Q-L--NV
P
L
I
GFSGA
P
F
T
L
A
S
Y
M
I------E------G--G---PSKNYNKT
K
A
-
F
M
YSMP
D
A
W
N
L
L
M
S
K
L
A
D
M
I
I
V
Y
V
K
A
Q
IEAG
A
K
A
I
Q
I
F
D
S
W
V
G
A
L
N
Q
A
D
Y
R
T
----
Y
I
K
P
V
M
N
R
I
F
S
E
L
A
K-----E-------N---V-
P
L
I
M
F
GVG
A
S
H
LAGDWHDLP
L
D
V
VGL
D
W
RLGI
D
E
A
R-SK-GITK-TVQGNLDP
S
I
L
LA
P
-
W
E
V
I
E
Q
K
T
K
E
I
L
D
QGM---ESD
G
F
I
F
NLGHGVFPDV
S
P
E
V
L
K
K
L
T
A
F
V
H
E
Y
SQNKKMGQYS
1
PsiBlast_PDB
91.81
99%
-123
- C2 -
2INF
-
DCUP_BACSU
A:
[6-349]
-----
T
F
N
E
T
F
L
K
A
A
R
G
E
K
A
D
H
T
P
V
W
Y
M
R
Q
A
G
R
S
Q
P
E
Y
R
K
L
K
-
E
-
K
Y
G
L
F
-
E
-
I
T
H
Q
P
E
L
C
A
Y
V
T
R
L
P
V
E
Q
Y
G
V
D
A
A
I
L
Y
K
D
I
M
T
P
L
P
S
I
G
V
D
V
E
I
K
N
G
I
G
P
V
I
D
Q
P
I
R
S
L
A
D
I
E
K
L
-
G
Q
I
D
-
P
-
E
---
Q
D
V
P
Y
V
L
---
E
T
I
K
L
L
V
N
E
-
Q
-
L
--
N
V
P
L
I
G
F
S
G
A
P
F
T
L
A
S
Y
M
T
------
E
------
G
--
G
---
P
S
K
N
Y
N
K
T
K
A
-
F
M
Y
S
M
P
D
A
W
N
L
L
M
S
K
L
A
D
M
I
I
V
Y
V
K
A
Q
I
K
A
G
A
K
A
I
Q
I
F
D
S
W
V
G
A
L
N
Q
A
D
Y
R
T
----
Y
I
K
P
V
M
N
R
I
F
S
E
L
A
K
-----
E
-------
N
---
V
-
P
L
I
M
F
G
V
G
A
S
H
L
A
G
D
W
H
D
L
P
L
D
V
V
G
L
D
W
R
L
G
I
D
E
A
R
-
S
K
-
G
I
T
K
-
T
V
Q
G
N
L
D
P
S
I
L
L
A
P
-
W
E
V
I
E
Q
K
T
K
E
I
L
D
Q
G
M
---
E
S
D
G
F
I
F
N
L
G
H
G
V
F
P
D
V
S
P
E
V
L
K
K
L
T
A
F
V
H
E
Y
S
Q
N
K
K
M
----
27
HHSearch
89.57
94%
-127
- C2 -
2INF
-
DCUP_BACSU
A:
[6-349]
-----
T
F
N
E
T
F
L
K
A
A
R
G
E
K
A
D
H
T
P
V
W
Y
M
R
Q
A
G
R
S
Q
P
E
Y
R
K
L
K
-
E
-
K
Y
G
L
F
-
E
-
I
T
H
Q
P
E
L
C
A
Y
V
T
R
L
P
V
E
Q
Y
G
V
D
A
A
I
L
Y
K
D
I
M
T
P
L
P
S
I
G
V
D
V
E
I
K
N
G
I
G
P
V
I
D
Q
P
I
R
S
L
A
D
I
E
K
L
-
G
Q
I
D
-
P
-
E
---
Q
D
V
P
Y
V
L
---
E
T
I
K
L
L
V
N
E
-
Q
-
L
--
N
V
P
L
I
G
F
S
G
A
P
F
T
L
A
S
Y
M
T
------
E
GGPSKN
Y
--
N
---
K
T
------
K
A
-
F
M
Y
S
M
P
D
A
W
N
L
L
M
S
K
L
A
D
M
I
I
V
Y
V
K
A
Q
I
K
A
G
A
K
A
I
Q
I
F
D
S
W
V
G
A
L
N
Q
A
D
Y
R
T
----
Y
I
K
P
V
M
N
R
I
F
S
E
L
A
K
E
----
N
-------
V
---
P
-
L
I
M
F
G
V
G
A
S
-
H
L
A
G
D
W
H
D
L
P
L
D
V
V
G
L
D
W
R
L
G
I
D
E
A
R
-
S
K
-
G
I
T
K
-
T
V
Q
G
N
L
D
P
S
I
L
L
-
A
P
W
E
V
I
E
Q
K
T
K
E
I
L
D
Q
G
M
---
E
S
D
G
F
I
F
N
L
G
H
G
V
F
P
D
V
S
P
E
V
L
K
K
L
T
A
F
V
H
E
Y
S
Q
N
K
K
M
----
4
PsiBlast_PDB
79.47
41%
-138
- C2 -
2EJA
1
DCUP_AQUAE
A:
[4-335]
-------
N
D
L
L
L
R
S
L
R
G
E
P
I
G
R
F
P
V
W
L
M
R
Q
A
G
R
Y
M
P
E
Y
R
K
I
R
-
N
-
R
V
K
N
F
L
E
-
L
C
K
N
V
D
L
A
T
E
I
S
L
L
P
L
K
I
L
G
V
D
A
I
I
I
F
S
D
I
L
V
P
L
E
P
L
G
V
K
V
E
F
V
E
G
E
G
P
K
L
S
W
S
----
G
K
V
S
D
L
-
K
K
Y
D
-
P
-
S
---
Q
N
A
-
Y
V
Y
---
E
I
I
K
R
V
K
E
A
-
Q
-
D
--
E
V
P
V
I
G
F
A
G
A
P
F
T
L
L
S
Y
L
I
------
E
------
G
--
G
---
A
S
K
D
F
K
S
T
K
L
-
F
M
W
E
N
P
K
E
Y
K
R
L
M
D
I
L
T
E
T
V
L
A
Y
L
K
E
Q
I
K
A
G
A
D
V
V
Q
I
F
D
S
W
V
N
N
L
S
L
E
D
Y
G
E
----
Y
V
Y
P
Y
V
N
Y
L
I
S
E
L
K
D
F
----
S
-------
D
---
T
-
P
V
I
Y
F
F
R
G
S
S
S
F
I
D
L
A
V
D
Y
R
A
D
A
L
S
V
D
W
S
V
D
I
P
E
L
--
F
K
-
I
Y
D
K
-
G
F
Q
G
N
L
E
P
A
V
L
Y
A
S
-
E
E
V
I
E
E
K
T
L
G
L
L
R
R
I
P
---
V
K
T
R
Y
V
F
N
L
G
H
G
L
A
P
D
M
E
L
E
K
V
K
Y
L
V
D
L
V
K
S
F
----------
24
PsiBlast_CBE
78.09
37%
-130
- C2 -
1R3S
1
DCUP_HUMAN
A:
[13-362]
----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
G
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
-
P
-
E
V
V
A
S
E
L
G
Y
V
F
---
Q
A
I
T
-
L
T
R
Q
-
R
-
L
AG
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
FA
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
-----
A
-------
G
L
A
P
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
--------
18
PsiBlast_PDB
77.76
37%
-128
- C2 -
1R3W
1
DCUP_HUMAN
A:
[13-362]
----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
-
P
-
E
V
V
A
S
E
L
G
Y
V
F
---
Q
A
I
T
-
L
T
R
Q
-
R
-
L
AG
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
F
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
FA
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
-----
A
-------
G
L
A
P
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
--------
14
PsiBlast_PDB
77.69
37%
-129
- C2 -
3GW3
-
DCUP_HUMAN
A:
[13-362]
----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
-
P
-
E
V
V
A
S
E
L
G
Y
V
F
---
Q
A
I
T
-
L
T
R
Q
-
R
-
L
AG
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
FA
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
-----
A
-------
G
L
A
P
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
N
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
--------
9
PsiBlast_PDB
77.42
37%
-127
- C2 -
1R3Q
2
DCUP_HUMAN
A:
[13-362]
----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
-
P
-
E
V
V
A
S
E
L
G
Y
V
F
---
Q
A
I
T
-
L
T
R
Q
-
R
-
L
AG
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
FA
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
-----
A
-------
G
L
A
P
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
--------
20
PsiBlast_PDB
77.05
37%
-127
- C2 -
1R3V
2
DCUP_HUMAN
A:
[13-362]
----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
E
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
-
P
-
E
V
V
A
S
E
L
G
Y
V
F
---
Q
A
I
T
-
L
T
R
Q
-
R
-
L
AG
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
FA
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
-----
A
-------
G
L
A
P
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
--------
23
PsiBlast_CBE
77.00
37%
-128
- C2 -
1R3T
1
DCUP_HUMAN
A:
[13-362]
----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
G
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
-
P
-
E
V
V
A
S
E
L
G
Y
V
F
---
Q
A
I
T
-
L
T
R
Q
-
R
-
L
AG
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
FA
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
-----
A
-------
G
L
A
P
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
--------
11
PsiBlast_PDB
76.88
37%
-127
- C2 -
3GVQ
-
DCUP_HUMAN
A:
[13-362]
----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
-
P
-
E
V
V
A
S
E
L
G
Y
V
F
---
Q
A
I
T
-
L
T
R
Q
-
R
-
L
AG
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
FA
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
-----
A
-------
G
L
A
P
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
--------
10
PsiBlast_PDB
76.76
37%
-128
- C2 -
1R3Y
1
DCUP_HUMAN
A:
[13-362]
----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
-
P
-
E
V
V
A
S
E
L
G
Y
V
F
---
Q
A
I
T
-
L
T
R
Q
-
R
-
L
AG
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
FA
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
-----
A
-------
G
L
A
P
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
--------
8
PsiBlast_PDB
76.66
37%
-128
- C2 -
1URO
1
DCUP_HUMAN
A:
[13-362]
----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
-
P
-
E
V
V
A
S
E
L
G
Y
V
F
---
Q
A
I
T
-
L
T
R
Q
-
R
-
L
AG
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
FA
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
-----
A
-------
G
L
A
P
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
--------
48
Fugue
76.44
36%
-119
- C2 -
1URO
1
DCUP_HUMAN
A:
[10-366]
-
G
F
P
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
T
-
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
D
P
E
V
V
-
A
---
S
E
L
G
Y
V
F
---
Q
A
I
T
L
T
R
Q
R
L
A
-
G
--
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
-----
R
L
R
E
A
G
L
A
P
---
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
-
E
C
V
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
R
Q
----
25
PsiBlast_CBE
76.44
37%
-129
- C2 -
2Q71
1
DCUP_HUMAN
A:
[3-352]
----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
-
P
-
E
V
V
A
S
E
L
G
Y
V
F
---
Q
A
I
T
-
L
T
R
Q
-
R
-
L
AG
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
R
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
FA
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
-----
A
-------
G
L
A
P
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
--------
34
HHSearch
76.40
39%
-146
- C2 -
2EJA
1
DCUP_AQUAE
A:
[2-337]
-----
P
K
N
D
L
L
L
R
S
L
R
G
E
P
I
G
R
F
P
V
W
L
M
R
Q
A
G
R
Y
M
P
E
Y
R
K
I
R
-
N
R
V
K
N
F
L
-
E
-
L
C
K
N
V
D
L
A
T
E
I
S
L
L
P
L
K
I
L
G
V
D
A
I
I
I
F
S
D
I
L
V
P
L
E
P
L
G
V
K
V
E
F
V
E
G
E
G
P
K
----
L
S
W
S
G
K
V
S
D
L
-
K
K
Y
D
-
P
-
S
----
Q
N
A
Y
V
Y
---
E
I
I
K
R
V
K
E
A
-
Q
-
D
--
E
V
P
V
I
G
F
A
G
A
P
F
T
L
L
S
Y
L
I
E
GGASK
D
------
F
--
K
---
S
T
------
K
L
-
F
M
W
E
N
P
K
E
Y
K
R
L
M
D
I
L
T
E
T
V
L
A
Y
L
K
E
Q
I
K
A
G
A
D
V
V
Q
I
F
D
S
W
V
N
N
L
S
L
E
D
Y
G
E
----
Y
V
Y
P
Y
V
N
Y
L
I
S
E
L
K
D
F
----
S
-------
D
---
T
P
V
I
Y
F
F
R
G
S
-
S
S
F
I
D
L
A
V
D
Y
R
A
D
A
L
S
V
D
W
S
V
D
I
P
E
L
F
-
K
I
Y
D
--
K
-
G
F
Q
G
N
L
E
P
A
V
-
L
Y
A
S
E
E
V
I
E
E
K
T
L
G
L
L
R
R
I
P
---
V
K
T
R
Y
V
F
N
L
G
H
G
L
A
P
D
M
E
L
E
K
V
K
Y
L
V
D
L
V
K
S
F
P
L
--------
13
PsiBlast_PDB
76.17
37%
-125
- C2 -
1JPI
-
DCUP_HUMAN
A:
[13-362]
----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
-
P
-
E
V
V
A
S
E
L
G
Y
V
F
---
Q
A
I
T
-
L
T
R
Q
-
R
-
L
AG
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
LA
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
-----
A
-------
G
L
A
P
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
--------
28
HHSearch
76.01
36%
-128
- C2 -
1R3S
1
DCUP_HUMAN
A:
[11-366]
--
F
P
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
G
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
D
P
E
-
V
V
A
---
S
E
L
G
Y
V
F
---
Q
A
I
T
L
T
R
Q
R
-
L
A
G
--
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
GGGSST
M
--
A
---
Q
A
------
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
G
-------
L
A
P
-
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
-
E
C
V
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
-
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
F
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
R
Q
----
7
PsiBlast_PDB
75.81
37%
-125
- C2 -
3GW0
-
DCUP_HUMAN
A:
[13-362]
----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
-
P
-
E
V
V
A
S
E
L
G
Y
V
F
---
Q
A
I
T
-
L
T
R
Q
-
R
-
L
AG
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
FA
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
-----
A
-------
G
L
A
P
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
R
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
--------
49
Fugue
75.64
36%
-120
- C2 -
1URO
1
DCUP_HUMAN
A:
[10-366]
-
G
F
P
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
D
P
E
V
-
V
-
A
---
S
E
L
G
Y
V
F
---
Q
A
I
T
L
T
R
Q
R
L
A
-
G
--
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
-----
R
L
R
E
A
G
L
A
P
---
V
-
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
-
E
C
V
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
R
Q
----
15
PsiBlast_PDB
75.38
37%
-123
- C2 -
1JPH
-
DCUP_HUMAN
A:
[13-362]
----
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
-
A
-
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
-
P
-
E
V
V
A
S
E
L
G
Y
V
F
---
Q
A
I
T
-
L
T
R
Q
-
R
-
L
AG
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
------
E
------
G
--
G
---
G
S
S
T
M
A
Q
A
K
R
-
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
FA
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
-----
A
-------
G
L
A
P
V
-
P
M
I
T
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
-
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
-
F
---
G
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
--------
6
PsiBlast_PDB
73.42
39%
-121
- C2 -
4ZR8
6
?
A:
[14-360]
-------
N
D
R
F
L
R
A
L
L
R
E
P
V
D
T
T
P
I
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
E
T
R
-
S
-
K
A
G
--L
S
-
L
C
K
N
T
E
F
A
C
E
V
T
L
Q
P
L
R
R
Y
D
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
L
G
L
G
L
Y
F
E
T
G
E
G
P
K
F
H
K
T
V
R
T
E
Q
D
V
A
N
L
-
P
K
L
N
-
A
-
K
---
A
D
L
D
Y
V
M
N
A
V
S
T
I
R
S
A
L
G
G
-
Q
-----
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
------
E
------
G
--
G
---
S
S
K
E
F
R
F
T
K
Q
-
M
M
Y
A
Q
P
E
V
L
H
A
L
L
D
H
L
A
D
S
V
I
D
Y
L
N
A
Q
I
D
A
G
A
Q
A
I
Q
I
F
D
S
W
G
G
A
L
A
H
R
E
Y
V
E
----
F
S
L
N
Y
M
K
K
I
I
A
G
L
Q
R
-----
E
KDG
R
---
R
---
I
-
P
V
I
V
F
T
K
G
G
G
Q
W
L
E
P
M
I
T
T
G
A
D
A
L
G
L
D
W
T
T
P
L
N
T
A
R
-
T
T
-
V
A
G
R
V
A
L
Q
G
N
L
D
P
A
V
L
Y
G
S
-
A
A
S
I
E
K
A
V
K
A
M
L
D
D
A
Y
ANG
E
K
T
G
Y
V
A
N
L
G
H
G
I
T
Q
W
V
D
P
A
Q
P
K
I
F
V
D
T
V
H
E
Y
S
---------
22
PsiBlast_CBE
69.21
39%
-115
- C2 -
4ZR8
5
?
B:
[14-360]
-------
N
D
R
F
L
R
A
L
L
R
E
P
V
D
T
T
P
I
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
E
T
R
-
S
-
K
A
G
D
F
L
S
-
L
C
K
N
T
E
F
A
C
E
V
T
L
Q
P
L
R
R
Y
D
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
L
G
L
G
L
Y
F
E
T
G
E
G
P
K
F
H
K
T
V
R
T
E
Q
D
V
A
N
L
-
P
K
L
N
-
A
-
K
---
A
D
L
D
Y
V
M
N
A
V
S
T
I
R
S
A
L
G
G
-
Q
-----
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
------
E
------
G
--
G
---
S
S
K
E
F
R
F
T
K
Q
-
M
M
Y
A
Q
P
E
V
L
H
A
L
L
D
H
L
A
D
S
V
I
D
Y
L
N
A
Q
I
D
A
G
A
Q
A
I
Q
I
F
D
S
W
G
G
A
L
A
H
R
E
Y
V
E
----
F
S
L
N
Y
M
K
K
I
I
A
G
L
Q
R
-----
E
KDG
R
---
R
---
I
-
P
V
I
V
F
T
K
G
G
G
Q
W
L
E
P
M
I
T
T
G
A
D
A
L
G
L
D
W
T
T
P
L
N
T
A
R
-
T
T
-
V
A
G
R
V
A
L
Q
G
N
L
D
P
A
V
L
Y
G
S
-
A
A
S
I
E
K
A
V
K
A
M
L
D
D
A
Y
ANG
E
K
T
G
Y
V
A
N
L
G
H
G
I
T
Q
W
V
D
P
A
Q
P
K
I
F
V
D
T
V
H
E
Y
S
---------
32
HHSearch
68.79
36%
-117
* C2 *
4ZR8
6
?
A:
[11-363]
----
T
L
K
N
D
R
F
L
R
A
L
L
R
E
P
V
D
T
T
P
I
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
E
T
R
S
K
-
A
G
--
L
-
S
-
L
C
K
N
T
E
F
A
C
E
V
T
L
Q
P
L
R
R
Y
D
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
L
G
L
G
L
Y
F
E
T
G
E
G
P
K
F
H
K
T
V
R
T
E
Q
D
V
A
N
L
-
P
K
L
N
-
A
-
K
---
A
D
L
D
Y
V
M
---
N
A
V
S
T
I
R
S
A
-
L
G
G
--
Q
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
------
E
------
G
GS
S
KEF
R
F
------
T
K
Q
M
M
Y
A
Q
P
E
V
L
H
A
L
L
D
H
L
A
D
S
V
I
D
Y
L
N
A
Q
I
D
A
G
A
Q
A
I
Q
I
F
D
S
W
G
G
A
L
A
H
R
E
Y
V
E
----
F
S
L
N
Y
M
K
K
I
I
A
G
L
Q
R
E----
K
DG
R
----
R
I
--
P
-
V
I
V
F
T
K
G
G
-
G
Q
W
L
E
P
M
I
T
T
G
A
D
A
L
G
L
D
W
T
T
P
L
N
T
A
R
-
T
T
V
A
G
R
V
-
A
L
Q
G
N
L
D
P
A
V
L
-
Y
G
S
A
A
S
I
E
K
A
V
K
A
M
L
D
D
A
Y
ANG
E
K
T
G
Y
V
A
N
L
G
H
G
I
T
Q
W
V
D
P
A
Q
P
K
I
F
V
D
T
V
H
E
Y
S
A
K
Y
------