@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu10850: (2016-06-17 )
MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAEQVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTLSLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGAPPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALTYIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDIIPDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLDVKRAYTGM
Atome Classification :
(20 SA)
.........10......-..20.......-.30........40........50.-.-......60........70........80........90........100.......110..-..-.-.-.-120.......130.......140.......150.......160----..---.-.--.-.---.-----.-----.170.......180.......190.......200.......210.----......220.......230.......240........250-.-......---260-..----.-......270--.-...----.-.-.-.280.......290.......300...-....310.......320.......330.......340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEH
Q
V
R
C
A
V
L
GLGRL
G
Y
-
Y
H
A
K
N
L
V
TSVP-G
A
K
L
V
C
VGDPLK
G
R
A
E
Q
V
A
R
E
LG
I
-
E
-KWSE
D
P
Y
E
V
L
EDPGI
D
A
V
I
I
V
TPTSTHG
D
M
I
I
K
AAENG
K
Q
I
F
V
EK
P
L
T
L
S
L
E
ESK
A
A
S
E
K
V
-
K
E-T-
G
-
V
-
I
C
Q
V
G
F
M
RRFD
P
A
Y
A
D
A
K
RRI
D
A
G
EIGK
P
I
Y
YKGFTRDQGA------
P
P
---
A
-
E
--
F
-
I
---K-----H-----SG
G
I
F
I
D
C
S
I
H
D
Y
D
I
A
R
Y
L
L
G
A
E
ITSVSGHGRILN
N
P
F
M
E
Q
YG
D
V
----
D
Q
A
L
T
Y
I
E
FDSGAAGDVEASRTSPYGH
D
-
I
R
A
E
V
IGTEG
S
-
I
-
F
I
G
T
LR---H---
Q
H
----
V
-
T
I
L
SAKG-S--S-
F
D
I----I-P-
D
-
F
Q
T
R
F
H
E
A
Y
C
L
E
L
Q
H
F
A
E
C
V
RNGKT
P
I
-
V
T
DI
D
A
T
I
N
L
E
V
G
I
A
A
TNSFRNGM
P
V
Q
L
D
V
K
R
AYTGM
1
PsiBlast_PDB
88.68
37%
-99
- C1 -
3EZY
2
?
A:
[2-332]
---
S
L
R
I
G
V
I
G
L
G
R
I
G
T
-
I
H
A
E
N
L
-
K
M
I
D
-
D
A
I
L
Y
A
I
S
D
V
R
E
D
R
L
R
E
M
K
E
K
L
G
V
-
E
-
K
A
Y
K
D
P
H
E
L
I
E
D
P
N
V
D
A
V
L
V
C
S
S
T
N
T
H
S
E
L
V
I
A
C
A
K
A
K
K
H
V
F
C
E
K
P
L
S
L
N
L
A
D
V
D
R
M
I
E
E
T
-
K
K
-
A
-
D
-
V
-
I
L
F
T
G
F
N
R
R
F
D
R
N
F
K
K
L
K
E
A
V
E
N
G
T
I
G
K
P
H
V
L
R
I
T
S
R
D
P
A
P
------
P
P
---
L
-
D
--
Y
-
I
---
R
-----
V
-----
S
G
G
I
F
L
D
M
T
I
H
D
F
D
M
A
R
Y
I
M
G
E
E
V
E
E
V
F
A
D
G
S
V
L
V
D
E
E
I
G
K
A
G
D
V
----
D
T
A
V
V
V
L
R
F
K
S
G
A
L
G
V
I
D
N
S
R
R
A
V
Y
G
Y
D
-
Q
R
I
E
V
F
G
S
K
G
R
-
I
-
F
A
D
N
V
R
---
E
---
T
T
----
V
-
V
L
T
D
E
Q
G
-
D
--
R
G
S
R
Y
----
L
-
Y
-
F
-
F
L
E
R
Y
R
D
S
Y
L
E
E
L
K
T
F
I
K
N
V
K
S
G
E
P
P
A
-
V
S
G
E
D
G
K
M
A
L
L
L
G
Y
A
A
K
K
S
L
E
E
K
R
S
V
K
L
E
--------
23
PsiBlast_CBE
88.44
37%
-99
- C1 -
3EZY
2
?
B:
[3-332]
----
L
R
I
G
V
I
G
L
G
R
I
G
T
-
I
H
A
E
N
L
-
K
M
I
D
-
D
A
I
L
Y
A
I
S
D
V
R
E
D
R
L
R
E
M
K
E
K
L
G
V
-
E
-
K
A
Y
K
D
P
H
E
L
I
E
D
P
N
V
D
A
V
L
V
C
S
S
T
N
T
H
S
E
L
V
I
A
C
A
K
A
K
K
H
V
F
C
E
K
P
L
S
L
N
L
A
D
V
D
R
M
I
E
E
T
-
K
K
-
A
-
D
-
V
-
I
L
F
T
G
F
N
R
R
F
D
R
N
F
K
K
L
K
E
A
V
E
N
G
T
I
G
K
P
H
V
L
R
I
T
S
R
D
P
A
P
------
P
P
---
L
-
D
--
Y
-
I
---
R
-----
V
-----
S
G
G
I
F
L
D
M
T
I
H
D
F
D
M
A
R
Y
I
M
G
E
E
V
E
E
V
F
A
D
G
S
V
L
V
D
E
E
I
G
K
A
G
D
V
----
D
T
A
V
V
V
L
R
F
K
S
G
A
L
G
V
I
D
N
S
R
R
A
V
Y
G
Y
D
-
Q
R
I
E
V
F
G
S
K
G
R
-
I
-
F
A
D
N
V
R
---
E
---
T
T
----
V
-
V
L
T
D
E
Q
G
-
D
--
R
G
S
R
Y
----
L
-
Y
-
F
-
F
L
E
R
Y
R
D
S
Y
L
E
E
L
K
T
F
I
K
N
V
K
S
G
E
P
P
A
-
V
S
G
E
D
G
K
M
A
L
L
L
G
Y
A
A
K
K
S
L
E
E
K
R
S
V
K
L
E
--------
22
PsiBlast_CBE
88.19
37%
-99
- C1 -
3EZY
4
?
C:
[3-332]
----
L
R
I
G
V
I
G
L
G
R
I
G
T
-
I
H
A
E
N
L
-
K
M
I
---
A
I
L
Y
A
I
S
D
V
R
E
D
R
L
R
E
M
K
E
K
L
G
V
-
E
-
K
A
Y
K
D
P
H
E
L
I
E
D
P
N
V
D
A
V
L
V
C
S
S
T
N
T
H
S
E
L
V
I
A
C
A
K
A
K
K
H
V
F
C
E
K
P
L
S
L
N
L
A
D
V
D
R
M
I
E
E
T
-
K
K
-
A
-
D
-
V
-
I
L
F
T
G
F
N
R
R
F
D
R
N
F
K
K
L
K
E
A
V
E
N
G
T
I
G
K
P
H
V
L
R
I
T
S
R
D
P
A
P
------
P
P
---
L
-
D
--
Y
-
I
---
R
-----
V
-----
S
G
G
I
F
L
D
M
T
I
H
D
F
D
M
A
R
Y
I
M
G
E
E
V
E
E
V
F
A
D
G
S
V
L
V
D
E
E
I
G
K
A
G
D
V
----
D
T
A
V
V
V
L
R
F
K
S
G
A
L
G
V
I
D
N
S
R
R
A
V
Y
G
Y
D
-
Q
R
I
E
V
F
G
S
K
G
R
-
I
-
F
A
D
N
V
R
---
E
---
T
T
----
V
-
V
L
T
D
E
Q
G
-
D
--
R
G
S
R
Y
----
L
-
Y
-
F
-
F
L
E
R
Y
R
D
S
Y
L
E
E
L
K
T
F
I
K
N
V
K
S
G
E
P
P
A
-
V
S
G
E
D
G
K
M
A
L
L
L
G
Y
A
A
K
K
S
L
E
E
K
R
S
V
K
L
E
--------
21
PsiBlast_CBE
87.52
37%
-101
- C1 -
3EZY
3
?
D:
[3-332]
----
L
R
I
G
V
I
G
L
G
R
I
G
T
-
I
H
A
E
N
L
-
K
M
I
---
A
I
L
Y
A
I
S
D
V
R
E
D
R
L
R
E
M
K
E
K
L
G
V
-
E
-
K
A
Y
K
D
P
H
E
L
I
E
D
P
N
V
D
A
V
L
V
C
S
S
T
N
T
H
S
E
L
V
I
A
C
A
K
A
K
K
H
V
F
C
E
K
P
L
S
L
N
L
A
D
V
D
R
M
I
E
E
T
-
K
K
-
A
-
D
-
V
-
I
L
F
T
G
F
N
R
R
F
D
R
N
F
K
K
L
K
E
A
V
E
N
G
T
I
G
K
P
H
V
L
R
I
T
S
R
D
P
A
P
------
P
P
---
L
-
D
--
Y
-
I
---
R
-----
V
-----
S
G
G
I
F
L
D
M
T
I
H
D
F
D
M
A
R
Y
I
M
G
E
E
V
E
E
V
F
A
D
G
S
V
L
V
D
E
E
I
G
K
A
G
D
V
----
D
T
A
V
V
V
L
R
F
K
S
G
A
L
G
V
I
D
N
S
R
R
A
V
Y
G
Y
D
-
Q
R
I
E
V
F
G
S
K
G
R
-
I
-
F
A
D
N
V
R
---
E
---
T
T
----
V
-
V
L
T
D
E
Q
G
-
D
--
R
G
S
R
Y
----
L
-
Y
-
F
-
F
L
E
R
Y
R
D
S
Y
L
E
E
L
K
T
F
I
K
N
V
K
S
G
E
P
P
A
-
V
S
G
E
D
G
K
M
A
L
L
L
G
Y
A
A
K
K
S
L
E
E
K
R
S
V
K
L
E
--------
36
HHSearch
81.75
36%
-99
- C1 -
3EZY
2
?
A:
[2-335]
---
S
L
R
I
G
V
I
G
L
G
R
I
G
T
-
I
H
A
E
N
L
K
M
-
I
D
-
D
A
I
L
Y
A
I
S
D
V
R
E
D
R
L
R
E
M
K
E
K
L
G
V
-
E
-
K
A
Y
K
D
P
H
E
L
I
E
D
P
N
V
D
A
V
L
V
C
S
S
T
N
T
H
S
E
L
V
I
A
C
A
K
A
K
K
H
V
F
C
E
K
P
L
S
L
N
L
A
D
V
D
R
M
I
E
E
T
-
K
K
-
A
-
D
-
V
-
I
L
F
T
G
F
N
R
R
F
D
R
N
F
K
K
L
K
E
A
V
E
N
G
T
I
G
K
P
H
V
L
R
I
T
S
R
D
P
A
-------
P
P
---
P
L
D
--
Y
-
I
---
R
-----
V
-----
S
G
G
I
F
L
D
M
T
I
H
D
F
D
M
A
R
Y
I
M
G
E
E
V
E
E
V
F
A
D
G
S
V
L
V
D
E
E
I
G
K
A
G
D
V
----
D
T
A
V
V
V
L
R
F
K
S
G
A
L
G
V
I
D
N
S
R
R
A
V
Y
G
-
Y
D
Q
R
I
E
V
F
G
S
K
G
R
-
I
F
A
D
N
V
R
E
---
T
----
T
----
V
-
V
L
T
D
E
Q
G
-
D
--
R
-
G
S
R
----
Y
L
Y
-
F
-
F
L
E
R
Y
R
D
S
Y
L
E
E
L
K
T
F
I
K
N
V
K
S
G
E
-
P
P
A
V
S
G
E
D
G
K
M
A
L
L
L
G
Y
A
A
K
K
S
L
E
E
K
R
S
V
K
L
E
E
V
I
-----
6
PsiBlast_PDB
79.91
31%
-107
- C1 -
3CEA
1
?
A:
[9-346]
----
L
R
A
A
I
I
G
L
G
R
L
G
E
-
R
H
A
R
H
L
V
N
K
I
Q
-
G
V
K
L
V
A
A
C
A
L
D
S
N
Q
L
E
W
A
K
N
E
L
G
V
-
E
-
T
T
Y
T
N
Y
K
D
M
I
D
T
E
N
I
D
A
I
F
I
V
A
P
T
P
F
H
P
E
M
T
I
Y
A
M
N
A
G
L
N
V
F
C
E
K
P
L
G
L
D
F
N
E
V
D
E
M
A
K
V
I
-
K
S
H
P
-
N
-
Q
-
I
F
Q
S
G
F
M
R
R
Y
D
D
S
Y
R
Y
A
K
K
I
V
D
N
G
D
I
G
K
I
I
Y
M
R
G
Y
G
I
D
P
I
S
------
G
M
---
E
-
S
--
F
-
T
---
K
-----
F
A
T
E
AD
S
G
G
I
F
V
D
M
N
I
H
D
I
D
L
I
R
W
F
T
G
Q
D
P
V
Q
A
Y
G
L
T
S
N
I
A
A
P
Q
L
A
D
I
G
E
F
----
E
T
G
V
A
Q
L
K
M
S
D
G
V
I
A
T
L
I
G
G
R
H
A
A
H
G
N
Q
-
V
E
L
E
V
M
G
S
N
G
W
-
V
-
R
I
G
--
E
---
H
PDL
N
R
----
V
-
T
V
F
N
D
Q
G
-
V
--
V
-
R
P
S
----
L
-
Q
-
S
-
F
G
E
R
F
D
T
A
F
T
D
E
V
Q
D
F
V
N
N
V
I
V
G
K
Q
P
E
-
V
T
V
D
D
G
I
K
A
L
K
I
A
K
A
C
Q
Q
S
A
N
I
G
K
L
V
D
I
Q
L
-------
33
HHSearch
76.64
35%
-108
- C1 -
4HKT
13
MI2D_RHIME
A:
[3-331]
---
T
V
R
F
G
L
L
G
A
G
R
I
G
K
-
V
H
A
K
A
V
S
G
-
N
A
-
D
A
R
L
V
A
V
A
D
A
F
P
A
A
A
E
A
I
A
G
A
Y
G
C
---
E
-
V
R
T
I
D
A
I
E
A
A
A
D
I
D
A
V
V
I
C
T
P
T
D
T
H
A
D
L
I
E
R
F
A
R
A
G
K
A
I
F
C
E
K
P
I
D
L
D
A
E
R
V
R
A
C
L
K
V
V
-
S
D
-
T
-
K
-
A
-
K
L
M
V
G
F
N
R
R
F
D
P
H
F
M
A
V
R
K
A
I
D
D
G
R
I
G
E
V
E
M
V
T
I
T
S
R
D
P
S
A
------
P
P
---
V
-
D
--
Y
-
I
---
K
-----
R
-----
S
G
G
I
F
R
D
M
T
I
H
D
F
D
M
A
R
F
L
L
G
E
E
P
V
S
V
T
A
T
A
A
V
L
I
D
K
A
I
G
D
A
G
D
Y
----
D
S
V
S
V
I
L
Q
T
A
S
G
K
Q
A
I
I
S
N
S
R
R
A
T
Y
G
-
Y
D
Q
R
I
E
V
H
G
S
K
G
A
-
V
A
A
E
N
Q
R
P
---
V
----
S
----
I
-
E
I
A
T
G
D
G
-
Y
--
T
R
P
P
L
----
H
-
D
-
F
-
F
M
T
R
Y
T
E
A
Y
A
N
E
I
E
S
F
I
A
A
I
E
K
G
A
-
E
I
A
P
S
G
N
D
G
L
A
A
L
A
L
A
D
A
A
V
R
S
V
A
E
K
R
Q
I
S
I
A
--------
34
HHSearch
75.20
31%
-107
- C1 -
3CEA
1
?
A:
[5-345]
T
R
K
P
L
R
A
A
I
I
G
L
G
R
L
G
E
-
R
H
A
R
H
L
V
N
K
I
Q
-
G
V
K
L
V
A
A
C
A
L
D
S
N
Q
L
E
W
A
K
N
E
L
G
V
-
E
-
T
T
Y
T
N
Y
K
D
M
I
D
T
E
N
I
D
A
I
F
I
V
A
P
T
P
F
H
P
E
M
T
I
Y
A
M
N
A
G
L
N
V
F
C
E
K
P
L
G
L
D
F
N
E
V
D
E
M
A
K
V
I
-
K
S
-
H
P
N
-
Q
-
I
F
Q
S
G
F
M
R
R
Y
D
D
S
Y
R
Y
A
K
K
I
V
D
N
G
D
I
G
K
I
I
Y
M
R
G
Y
G
I
D
P
I
S
G-----
M
E
---
S
-
F
T
K
F
A
T
E
--
A
-----
D
-----
S
G
G
I
F
V
D
M
N
I
H
D
I
D
L
I
R
W
F
T
G
Q
D
P
V
Q
A
Y
G
L
T
S
N
I
A
A
P
Q
L
A
D
I
G
E
F
----
E
T
G
V
A
Q
L
K
M
S
D
G
V
I
A
T
L
I
G
G
R
H
A
A
H
G
-
N
Q
V
E
L
E
V
M
G
S
N
G
W
-
V
-
R
I
G
E
H
P
-------
D
L
----
N
-
R
V
T
V
F
N
D
-
Q
--
G
-
V
V
R
----
P
S
L
Q
S
-
F
G
E
R
F
D
T
A
F
T
D
E
V
Q
D
F
V
N
N
V
I
V
G
K
-
Q
P
E
V
T
V
D
D
G
I
K
A
L
K
I
A
K
A
C
Q
Q
S
A
N
I
G
K
L
V
D
I
Q
--------
2
PsiBlast_PDB
74.38
30%
-94
- C1 -
4N54
2
?
A:
[15-350]
----
I
K
I
G
I
V
G
L
G
R
L
G
K
-
I
H
A
T
N
I
A
T
K
I
Q
-
H
A
K
L
Q
A
A
T
S
V
V
P
A
E
L
D
W
A
K
K
E
L
G
V
-
E
-
E
V
F
E
D
F
D
D
M
V
Q
H
A
D
I
D
A
V
F
I
V
S
P
S
G
F
H
L
Q
Q
I
E
S
A
L
N
A
G
K
H
V
F
S
E
K
P
I
G
L
D
I
E
A
I
E
H
T
Q
Q
V
I
-
A
Q
H
A
-
N
-
L
-
K
F
Q
L
G
F
M
R
R
F
D
D
S
Y
R
Y
A
K
Q
L
V
D
Q
G
K
I
G
D
I
T
L
I
R
S
Y
S
I
D
P
A
A
------
G
M
---
A
-
S
--
F
-
V
---
K
F
A
T
S
A
N
-----
S
G
G
L
F
L
D
M
S
I
H
D
I
D
V
I
R
W
F
T
G
K
E
I
D
K
V
W
A
I
G
L
N
R
A
Y
P
V
L
D
K
A
G
E
L
----
E
T
G
A
A
L
M
Q
L
E
D
K
T
M
A
I
L
V
A
G
R
N
A
A
H
G
Y
H
-
V
E
T
E
I
I
G
T
K
G
M
-
L
-
R
I
A
Q
V
P
---
E
---
K
N
L---
V
-
T
V
M
N
E
E
G
-
I
--
I
-
R
P
T
----
S
-
Q
-
N
-
F
P
E
R
F
A
Q
A
F
L
S
E
E
Q
A
F
V
N
S
I
L
N
N
Q
D
V
G
-
I
T
A
E
D
G
L
Q
G
T
K
A
A
L
A
L
Q
E
A
F
E
K
N
D
I
V
Q
V
---------
45
HHSearch
72.25
32%
-93
- C1 -
3EUW
1
?
A:
[3-335]
--
L
T
L
R
I
A
L
F
G
A
G
R
I
G
H
-
V
H
A
A
N
I
A
A
-
N
P
-
D
L
E
L
V
V
I
A
D
P
F
I
E
G
A
Q
R
L
A
E
A
N
G
A
---
E
A
V
A
S
P
D
E
V
F
A
R
D
D
I
D
G
I
V
I
G
S
P
T
S
T
H
V
D
L
I
T
R
A
V
E
R
G
I
P
A
L
C
E
K
P
I
D
L
D
I
E
M
V
R
A
C
K
E
K
I
-
G
D
-
G
-
A
-
S
-
K
V
M
L
G
F
N
R
R
F
D
P
S
F
A
A
I
N
A
R
V
A
N
Q
E
I
G
N
L
E
Q
L
V
I
I
S
R
D
P
A
P
------
A
P
---
K
-
D
--
Y
-
I
---
A
-----
G
-----
S
G
G
I
F
R
D
M
T
I
H
D
L
D
M
A
R
F
F
V
P
N
-
I
V
E
V
T
A
T
G
A
N
V
F
S
Q
E
I
A
E
F
N
D
Y
----
D
Q
V
I
V
T
L
R
G
S
K
G
E
L
I
N
I
V
N
S
R
H
C
S
Y
G
Y
D
-
Q
R
L
E
A
F
G
S
K
G
M
-
L
A
A
D
N
I
R
P
-------
T
T
----
V
-
R
K
H
N
A
E
S
-
T
--
E
-
Q
A
D
----
P
I
F
-
N
F
F
L
E
R
Y
D
A
A
Y
K
A
E
L
A
T
F
A
Q
G
I
R
D
G
Q
-
G
F
S
P
N
F
E
D
G
V
I
A
L
E
L
A
N
A
C
L
E
S
A
Q
T
G
R
T
V
T
L
N
P
A
------
41
HHSearch
71.75
27%
-110
- C1 -
3EC7
5
IOLG_SALTY
A:
[22-353]
--
M
T
L
K
A
G
I
V
G
I
G
M
I
G
S
-
D
H
L
R
R
L
A
N
T
V
S
-
G
V
E
V
V
A
V
C
D
I
V
A
G
R
A
Q
A
A
L
D
K
Y
A
I
-
E
A
K
D
Y
N
D
Y
H
D
L
I
N
D
K
D
V
E
V
V
I
I
T
A
S
N
E
A
H
A
D
V
A
V
A
A
L
N
A
N
K
Y
V
F
C
E
K
P
L
A
V
T
A
A
D
C
Q
R
V
I
E
A
E
-
Q
K
-
N
-
G
-
K
R
M
V
Q
I
G
F
M
R
R
Y
D
K
G
Y
V
Q
L
K
N
I
I
D
S
G
E
I
G
Q
P
L
M
V
H
G
R
H
Y
N
A
S
T
------
V
P
-----
E
--------
Y
-----
K
-----
T
P
Q
A
I
Y
E
T
L
I
H
E
I
D
V
M
H
W
L
L
N
E
D
Y
K
T
V
K
V
Y
F
P
R
Q
S
S
L
V
---
T
T
L
R
----
D
P
Q
L
V
V
M
E
T
T
S
G
I
N
I
V
V
E
V
F
V
N
C
Q
Y
G
-
Y
D
I
H
C
D
V
T
G
E
K
G
M
-
A
-
E
L
P
T
V
A
--------
S
----
A
-
A
V
R
K
A
A
K
-
Y
--
S
-
T
D
I
----
L
-
V
-
D
-
W
K
Q
R
F
I
D
A
Y
D
I
E
F
Q
D
F
F
D
R
L
N
A
G
L
P
P
A
G
P
T
S
W
D
G
Y
L
A
A
V
T
A
D
A
C
V
K
S
Q
E
T
G
N
T
E
I
V
E
L
P
S
K
P
---
4
PsiBlast_PDB
71.04
32%
-94
- C1 -
3EUW
1
?
A:
[5-333]
----
L
R
I
A
L
F
G
A
G
R
I
G
H
-
V
H
A
A
N
I
A
A
N
-
P
-
D
L
E
L
V
V
I
A
D
P
F
I
E
G
A
Q
R
L
A
E
A
N
G
A
-
E
-
A
V
A
S
-
P
D
E
V
F
A
R
D
D
I
D
G
I
V
I
G
S
P
T
S
T
H
V
D
L
I
T
R
A
V
E
R
G
I
P
A
L
C
E
K
P
I
D
L
D
I
E
M
V
R
A
C
K
E
K
I
-
G
D
-
G
-
A
-
S
-
K
V
M
L
G
F
N
R
R
F
D
P
S
F
A
A
I
N
A
R
V
A
N
Q
E
I
G
N
L
E
Q
L
V
I
I
S
R
D
P
A
P
------
A
P
---
K
-
D
--
Y
-
I
---
A
-----
G
-----
S
G
G
I
F
R
D
M
T
I
H
D
L
D
M
A
R
F
F
V
-
P
N
I
V
E
V
T
A
T
G
A
N
V
F
S
Q
E
I
A
E
F
N
D
Y
----
D
Q
V
I
V
T
L
R
G
S
K
G
E
L
I
N
I
V
N
S
R
H
C
S
Y
G
Y
D
-
Q
R
L
E
A
F
G
S
K
G
M
-
L
-
A
A
D
N
I
R
---
P
---
T
T
----
V
-
R
K
H
N
A
E
S
-
T
E
Q
A
-
D
P
I
----
F
-
N
-
F
-
F
L
E
R
Y
D
A
A
Y
K
A
E
L
A
T
F
A
Q
G
I
R
D
G
Q
G
F
S
-
P
N
F
E
D
G
V
I
A
L
E
L
A
N
A
C
L
E
S
A
Q
T
G
R
T
V
T
L
N
--------
3
PsiBlast_PDB
69.48
30%
-100
- C1 -
4MKZ
1
?
A:
[18-353]
----
I
K
I
G
I
V
G
L
G
R
L
G
K
-
I
H
A
T
N
I
A
T
K
I
Q
-
H
A
K
L
Q
A
A
T
S
V
V
P
A
E
L
D
W
A
K
K
E
L
G
V
-
E
-
E
V
F
E
D
F
D
D
M
V
Q
H
A
D
I
D
A
V
F
I
V
S
P
S
G
F
H
L
Q
Q
I
E
S
A
L
N
A
G
K
H
V
F
S
E
K
P
I
G
L
D
I
E
A
I
E
H
T
Q
Q
V
I
-
A
Q
H
A
-
N
-
L
-
K
F
Q
L
G
F
M
R
R
F
D
D
S
Y
R
Y
A
K
Q
L
V
D
Q
G
K
I
G
D
I
T
L
I
R
S
Y
S
I
D
P
A
A
------
G
M
---
A
-
S
--
F
-
V
---------------
S
G
G
L
F
L
D
M
S
I
H
D
I
D
V
I
R
W
F
T
G
K
E
I
D
K
V
W
A
I
G
L
N
R
A
Y
P
V
L
D
K
A
G
E
L
----
E
T
G
A
A
L
M
Q
L
E
D
K
T
M
A
I
L
V
A
G
R
N
A
A
H
G
Y
H
-
V
E
T
E
I
I
G
T
K
G
M
-
L
-
R
I
A
Q
V
P
---
E
---
K
N
L---
V
-
T
V
M
N
E
E
G
-
I
--
I
-
R
P
T
----
S
-
Q
-
N
-
F
P
E
R
F
A
Q
A
F
L
S
E
E
Q
A
F
V
N
S
I
L
N
N
Q
D
V
G
-
I
T
A
E
D
G
L
Q
G
T
K
A
A
L
A
L
Q
E
A
F
E
K
N
D
I
V
Q
V
---------
5
PsiBlast_PDB
63.50
38%
-110
- C1 -
4HKT
11
MI2D_RHIME
A:
[4-298]
----
V
R
F
G
L
L
G
A
G
R
I
G
K
-
V
H
A
K
-
A
V
S
G
N
A
-
D
A
R
L
V
A
V
A
D
A
F
P
A
A
A
E
A
I
A
G
A
Y
G
C
-
E
-
V
R
T
I
D
A
I
E
A
A
A
--
D
I
D
A
V
V
I
C
T
P
T
D
T
H
A
D
L
I
E
R
F
A
R
A
G
K
A
I
F
C
E
K
P
I
D
L
D
A
E
R
V
R
A
C
L
K
V
V
-
S
D
-
T
-
K
-
A
-
K
L
M
V
G
F
N
R
R
F
D
P
H
F
M
A
V
R
K
A
I
D
D
G
R
I
G
E
V
E
M
V
T
I
T
S
R
D
P
S
A
------
P
P
---
V
-
D
--
Y
-
I
---
K
-----
R
-----
S
G
G
I
F
R
D
M
T
I
H
D
F
D
M
A
R
F
L
L
G
E
E
P
V
S
V
T
A
T
A
A
V
L
I
D
K
A
I
G
D
A
G
D
Y
----
D
S
V
S
V
I
L
Q
T
A
S
G
K
Q
A
I
I
S
N
S
R
R
A
T
Y
G
Y
D
-
Q
R
I
E
V
H
G
S
K
G
A
-
V
-
A
A
E
N
Q
R
---
P
---
V
S
----
I
-
E
I
A
T
G
D
G
-
Y
--
T
-
R
P
P
----
L
-
H
-
D
F
F
M
T
R
Y
T
E
A
Y
A
N
E
I
E
S
F
I
A
A
I
E
K
G
------------------------------------------
44
HHSearch
62.85
25%
-107
- C1 -
3MZ0
8
IOLG_BACSU
A:
[1-333]
--
M
S
L
R
I
G
V
I
G
T
G
A
I
G
K
-
E
H
I
N
R
I
T
N
K
L
S
-
G
A
E
I
V
A
V
T
D
V
N
Q
E
A
A
Q
K
V
V
E
Q
Y
Q
L
-
N
A
T
V
Y
P
N
D
D
S
L
L
A
D
E
N
V
D
A
V
L
V
T
S
W
G
P
A
H
E
S
S
V
L
K
A
I
K
A
Q
K
Y
V
F
C
E
K
P
L
A
T
T
A
E
G
C
M
R
I
V
E
E
E
-
I
K
-
V
-
G
K
R
-
L
V
Q
V
G
F
M
R
R
Y
D
S
G
Y
V
Q
L
K
E
A
L
D
N
H
V
I
G
E
P
L
M
I
H
C
A
H
R
N
P
T
-------
V
G
---
D
-
N
--------
Y
-----
T
-----
T
D
M
A
V
V
D
T
L
V
H
E
I
D
V
L
H
W
L
V
N
D
D
Y
E
S
V
Q
V
I
Y
P
K
K
S
K
N
A
--
L
P
H
L
K
----
D
P
Q
I
V
V
I
E
T
K
G
G
I
V
I
N
A
E
I
Y
V
N
C
K
Y
G
-
Y
D
I
Q
C
E
I
V
G
E
D
G
I
-
I
-
K
L
P
E
P
S
--------
S
----
I
-
S
L
R
K
E
G
R
-
F
--
S
-
T
D
I
----
L
-
M
-
D
-
W
Q
R
R
F
V
A
A
Y
D
V
E
I
Q
D
F
I
D
S
I
Q
K
K
G
E
V
S
G
P
T
A
W
D
G
Y
I
A
A
V
T
T
D
A
C
V
K
A
Q
E
S
G
Q
K
E
K
V
E
L
K
E
K
P
---
37
HHSearch
57.73
22%
-100
* C1 *
4KOA
1
AFR_RHIME
A:
[1-332]
---
M
I
R
W
G
L
I
G
A
S
T
I
A
R
-
E
W
V
I
G
A
I
R
-
A
A
-
G
G
E
V
V
S
V
M
S
S
S
A
E
R
G
E
A
Y
A
A
E
N
G
I
-
A
-
K
A
V
T
S
V
D
D
L
V
G
D
P
D
V
D
A
V
Y
I
S
T
T
N
E
L
H
H
G
Q
A
L
A
A
I
R
A
G
K
H
V
L
C
E
K
P
L
A
M
N
L
N
D
G
C
E
M
V
L
K
A
-
C
E
-
A
-
G
-
V
-
V
L
G
T
N
H
H
L
R
N
A
A
T
H
R
A
M
R
E
A
I
A
A
G
R
I
G
R
P
I
A
A
R
V
F
H
A
V
Y
L
-------
P
P
HLQ
G
-
W
--
R
-
L
DKP
E
-----
A
-----
G
G
G
V
I
L
D
I
T
V
H
D
A
D
T
L
R
F
V
L
N
D
D
P
I
E
A
V
A
I
S
H
S
A
G
M
G
K
---
E
G
L
E
----
D
G
V
M
G
V
L
R
F
R
S
G
V
I
A
Q
F
H
D
A
F
T
T
K
F
A
-
E
-
T
G
L
E
V
H
G
T
A
G
S
-
L
I
G
R
N
V
M
T
---
Q
---
R
P
V
---
G
-
T
V
V
L
-
R
N
------
E
E
G
----
E
-
S
-
E
-
L
P
L
D
H
R
N
L
Y
E
T
A
I
A
A
F
H
S
A
I
G
G
N
G
-
R
P
S
A
S
G
E
D
G
V
W
S
L
A
T
G
L
A
V
V
K
A
A
A
T
G
G
A
V
E
I
E
T
G
------
40
HHSearch
55.25
24%
-106
- C1 -
1ZH8
7
?
A:
[16-338]
-
L
R
K
I
R
L
G
I
V
G
C
G
I
A
A
R
E
L
H
L
P
A
L
K
N
-
L
S
H
L
F
E
I
T
A
V
T
S
R
T
R
S
H
A
E
E
F
A
K
M
V
G
N
-
P
-
A
V
F
D
S
Y
E
E
L
L
E
S
G
L
V
D
A
V
D
L
T
L
P
V
E
L
N
L
P
F
I
E
K
A
L
R
K
G
V
H
V
I
C
E
K
P
I
S
T
D
V
E
T
G
K
K
V
V
E
L
S
-
E
K
-
S
-
E
-
K
-
T
V
Y
I
A
E
N
F
R
H
V
P
A
F
W
K
A
K
E
L
V
E
S
G
A
I
G
D
P
V
F
M
N
W
Q
I
W
V
G
M
D
ENNKYV
H
T
---
D
-
W
--
R
-
K
K
P-
K
-----
H
-----
V
G
G
F
L
S
D
G
G
V
H
H
A
A
A
M
R
L
I
L
G
E
-
I
E
W
I
S
A
V
A
K
D
L
-
S
P
L
---
L
G
G
M
----
D
F
L
S
S
I
F
E
F
E
N
G
T
V
G
N
Y
T
I
S
Y
S
L
K
G
N
---
E
R
F
E
I
T
G
T
K
G
K
-
I
S
I
S
W
D
K
I
---------------
V
L
N
-----------
E
E
----
E
-----
M
K
V
P
Q
E
N
S
Y
Q
K
E
F
E
D
F
Y
Q
V
V
A
E
G
K
P
N
D
L
G
S
P
V
Q
A
L
K
D
L
A
F
I
E
A
C
V
R
S
A
G
N
K
V
F
V
S
S
---------
38
HHSearch
55.18
24%
-94
- C1 -
3DB2
-
?
A:
[2-352]
M
Y
N
P
V
G
V
A
A
I
G
L
G
R
W
A
Y
-
V
M
A
D
A
Y
T
K
-
S
E
-
K
L
K
L
V
T
C
Y
S
R
T
E
D
K
R
E
K
F
G
K
R
Y
N
C
---
A
G
D
A
T
M
E
A
L
L
A
R
E
D
V
E
M
V
I
I
T
V
P
N
D
K
H
A
E
V
I
E
Q
C
A
R
S
G
K
H
I
Y
V
E
K
P
I
S
V
S
L
D
H
A
Q
R
I
D
Q
V
I
-
K
E
-
T
-
G
-
V
-
K
F
L
C
G
H
S
S
R
R
L
G
A
L
R
K
M
K
E
M
I
D
T
K
E
I
G
E
V
S
S
I
E
A
V
F
S
N
E
R
G
LELK--
K
G
---
N
-
W
--
R
-
G
EPA
T
-----
A
-----
P
G
G
P
L
T
Q
L
G
V
H
Q
I
D
N
L
Q
F
L
L
G
P
-
V
A
R
V
F
N
F
G
K
P
M
-
Y
T
E
---
V
E
N
I
----
T
V
N
Q
T
L
L
E
F
E
D
G
K
Q
A
Y
L
G
T
N
W
A
C
P
G
V
---
F
S
I
N
V
Y
G
T
K
A
N
L
F
-
Y
Q
L
D
F
S
WWS
N
---
S
D
VTDE
H
S
T
L
I
K
R
E
F
A
S
------
N
R
I
L
R
D
-
V
-
K
-
V
D
F
E
S
V
D
H
L
R
V
E
V
E
E
V
A
D
V
I
R
N
G
G
-
E
T
E
I
G
A
E
A
S
L
R
N
L
A
V
V
L
A
A
V
K
S
V
H
E
K
R
P
V
E
I
A
E
I
------
35
HHSearch
52.11
28%
-87
- C1 -
4MIY
9
?
A:
[1-333]
--
M
V
V
K
V
G
V
I
G
T
G
A
M
G
R
-
A
H
I
D
R
L
T
N
V
L
T
-
G
A
E
V
V
A
V
T
D
I
D
H
E
A
A
E
A
A
V
R
D
F
H
L
N
A
-
K
V
Y
P
D
D
T
S
L
L
Q
D
P
D
I
D
A
V
F
V
V
S
F
G
G
A
H
E
A
T
V
L
K
A
L
D
T
D
K
F
I
F
T
E
K
P
L
A
T
T
L
E
G
A
K
R
I
V
D
K
E
L
T
K
-
S
-
K
-
K
-
V
I
Q
V
G
F
M
R
R
Y
D
Q
G
I
R
A
L
K
E
K
L
D
T
G
I
I
G
A
P
L
V
V
R
A
S
H
I
N
P
N
-------
V
A
---
S
-
N
--------
Y
-----
S
-----
N
E
M
A
I
T
D
T
L
I
H
E
I
D
E
M
H
W
L
L
D
D
E
Y
T
S
I
Q
I
T
Y
P
R
Q
S
A
-
E
V
R
N
E
G
L
H
----
D
P
Q
L
A
T
L
T
T
K
K
G
T
V
I
Q
V
L
V
H
V
T
A
Q
Y
G
-
Y
E
V
K
L
E
V
I
G
E
T
G
E
L
Q
-
L
P
N
Y
G
L
--------
G
----
P
-
I
L
R
S
N
A
N
-
Q
--
Q
-
T
A
V
----
E
-
M
-
S
-
W
I
N
R
F
I
Q
A
Y
N
T
E
V
Q
E
F
I
D
E
V
A
K
S
E
P
P
V
G
P
S
A
W
D
G
Y
I
A
A
I
T
A
A
A
A
N
R
S
Q
K
D
Q
E
T
V
L
I
N
V
A
G
-----
7
PsiBlast_PDB
49.51
29%
-112
- C1 -
3EC7
4
IOLG_SALTY
A:
[38-317]
-------------------
H
L
R
R
L
A
N
T
V
S
-
G
V
E
V
V
A
V
C
D
I
V
A
G
R
A
Q
A
A
L
D
K
Y
A
I
-
E
A
K
D
Y
N
D
Y
H
D
L
I
N
D
K
D
V
E
V
V
I
I
T
A
S
N
E
A
H
A
D
V
A
V
A
A
L
N
A
N
K
Y
V
F
C
E
K
P
L
A
V
T
A
A
D
C
Q
R
V
I
E
A
E
-
Q
K
-
N
-
G
-
K
R
M
V
Q
I
G
F
M
R
R
Y
D
K
G
Y
V
Q
L
K
N
I
I
D
S
G
E
I
G
Q
P
L
M
V
H
G
--
R
H
Y
N
A
------
S
T
---
V
-
P
--
E
-
Y
---
K
-----
T
-----
P
Q
A
I
Y
-
E
T
L
I
H
E
I
D
V
M
H
W
L
L
N
E
D
Y
K
T
V
K
V
Y
-------
F
P
R
Q
S
S
L
V
TTLR
D
P
Q
L
V
V
M
E
T
T
S
G
I
N
I
V
V
E
V
F
V
N
C
Q
Y
G
Y
D
-
I
H
C
D
V
T
G
E
K
G
M
-
A
-
E
L
P
T
V
--------
A
S
----
A
-
A
V
R
K
A
A
K
-
Y
--
S
-
T
D
I
----
L
-
V
-
D
-
W
K
Q
R
F
I
D
A
Y
D
I
E
F
Q
D
F
F
D
R
L
N
A
G
L
P
P
---------------------------------------