@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29930: (2016-07-18 )
MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFPLAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYYDGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLHGYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIYETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDFAGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVILDVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVVYWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAALANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALAPIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIHSGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSAADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLCDPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA
Atome Classification :
(20 SA)
.........10........20.......--.30.....-...40.---.......50........60.--.......70.........80.---.......90........100.--.-.....110--.--......120.......130---...-.-----...140...---.-..--.150.....-------.-----.160......----.170---------------------------......--.180....----------...190----------.--------------------------.------------....---...200---.----...----.-...-.----210.......220.......230..---......240.......250.......260.---......270.......280----.------.-------------------------------------------------------------.....290.......300......-----.310.......320....-...330.......340...----.----.-----..350------------..-.....360.-......370.......380.......390.......400.......410..------------..-------------------------------...420------------------------------.....--....-----430.......440-.-.-..-....450......--.460.......470...-------------....-----480.....--------..490--------------........500------------------....--------------..------------------.--510.........520.......530.....---.-.540---------------------------........-.550.......560.......570.....------------------------------.----------------------------------.580.......590....------..---------------------------------.600.......610.......620.......630..-------------.--------.--------...640.......650---.........660.......670..----..----...680.......690----------.---------------------.-......700.......710......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MV
S
I
R
R
S
F
E
A
Y
VDD
M
N
I
I
T
V
L
IPAEQKE--IMTPP
F
R
L
-ETEITD---FP
L
A
V
R
E
EYSLE
A
K
Y
K
Y
V
C
V--SDHPV
T
F
G
-
K
I
H
C
V
RASSGHK---T
D
L
Q
I
G
A
V
I
R
TAAFDD
E
F
Y
YD--G-EL
G
A
V
Y
TA--D--
H
T
V
F
K
V
WAPAAT
S
A
A
V
K
LS---HPN-K-----SG
R
T
F
Q
M
T
R---L-EK--
G
V
Y
A
V
T
V
TG-------D-----LHG
Y
E
Y
L
F
C
I
----CNN
S
---------------------------
E
W
M
E
T
V
--
D
Q
Y
A
K
A
V
T
----------VNGE------------K--------------------------
G
------------
V
V
LR---PDQ
M
-----
K
----WTA----P-LKP-F----SH
P
V
D
A
V
I
Y
E
THL
R
D
F
S
IHENS-GM---INKG
K
Y
L
A
L
TETDTQTANGSS
S
G
L
A
Y
V
K
EL---GV
T
H
V
E
L
L
PVNDFAGVDEE----K------P-------------------------------------------------------------LDAYNWGYN
P
L
H
F
FAPEGSYASNP-----HDP
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
KRE----N----S-----PFEKT------------VP-G
Y
F
F
RHDEC-GMPSNGTGVG
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
EYNVD
G
F
R
F
D
L
L
G
I
LDI
D
------------
T
V
-------------------------------
L
Y
M
K
--------------------------------EKATK--AKP
G
-----
I
L
L
F
GEGWDLAT--P-L-P
H
-
E
Q
K
A
A
LANAPRMP--GI
G
F
F
N
D
M
F
R
D
AVKG
N
T
-------------
F
H
L
K
-----
A
T
G
F
ALGN--------G
E
S
A
---------------
Q
A
V
M
H
G
IAGSS------------------GWKA--------------LA------------------P--I--VPEPSQSINYVESHDNH
T
F
W
D
K
M
SFAL---P-QE-----------------------------N
D
S
R
K
R
S
R
-
Q
R
L
A
A
A
I
I
L
L
AQGVPFIHS
G
Q
E
F
F
R
T
KQG------------------------------V----------------------------------ENSYQSSDSINQL
D
W
D
R
R
------
E
T
---------------------------------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
KAH
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
L
-------------
T
--------
L
--------
K
E
H
L
I
A
Y
RLY
D
L
D
E
-----
V
DEWK
D
I
I
V
I
HHASPD
S
V
E
W
RLPN----DI----
P
Y
R
L
L
CDPSGFQE
D
P
-----------
T
---------------------
E
-
I
K
K
T
V
A
VN
G
I
G
T
V
I
L
Y
L
A
S
D
L
K
SFA
2
PsiBlast_PDB
99.44
99%
-82
- C1 -
2E8Z
4
PULA_BACSU
A:
[1-712]
M
V
S
I
R
R
S
F
E
A
Y
V
D
D
M
N
I
I
T
V
L
I
P
A
E
Q
K
E
--
I
M
T
P
P
F
R
L
-
E
T
E
I
T
D
---
F
P
L
A
V
R
E
E
Y
S
L
E
A
K
Y
K
Y
V
C
V
--
S
D
H
P
V
T
F
G
-
K
I
H
C
V
R
A
S
S
G
H
K
---
T
D
L
Q
I
G
A
V
I
R
T
A
A
F
D
D
E
F
Y
Y
D
--
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
---
H
P
N
-
K
-----
S
G
R
T
F
Q
M
T
R
---
L
-
E
K
--
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
----
C
N
N
S
---------------------------
E
W
M
E
T
V
--
D
Q
Y
A
K
A
V
T
----------
V
N
G
E
------------
K
--------------------------
G
------------
V
V
L
R
---
P
D
Q
M
-----
K
----
W
T
A
----
P
-
L
K
P
-
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
-
G
M
---
I
N
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
---
G
V
T
H
V
E
L
L
P
V
N
D
F
A
G
V
D
E
E
----
K
------
P
-------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
----
S
-----
P
F
E
K
T
------------
V
P
-
G
Y
F
F
R
H
D
E
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
------------
T
V
-------------------------------
L
Y
M
K
--------------------------------
E
K
A
T
K
--
A
K
P
G
-----
I
L
L
F
G
E
G
W
D
L
A
T
--
P
-
L
-
P
H
-
E
Q
K
A
A
L
A
N
A
P
R
M
P
--
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
T
-------------
F
H
L
K
-----
A
T
G
F
A
L
G
N
--------
G
E
S
A
---------------
Q
A
V
M
H
G
I
A
G
S
S
------------------
G
W
K
A
--------------
L
A
------------------
P
--
I
--
V
P
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
L
---
P
-
Q
E
-----------------------------
N
D
S
R
K
R
S
R
-
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
G
------------------------------
V
----------------------------------
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
T
---------------------------------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
L
-------------
T
--------
L
--------
K
E
H
L
I
A
Y
R
L
Y
D
L
D
E
-----
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
W
R
L
P
N
----
D
I
----
P
Y
R
L
L
C
D
P
S
G
F
Q
E
D
P
-----------
T
---------------------
E
-
I
K
K
T
V
A
V
N
G
I
G
T
V
I
L
Y
L
A
S
------
38
HHSearch
99.30
100%
-82
- C1 -
2E8Y
3
PULA_BACSU
A:
[1-712]
M
V
S
I
R
R
S
F
E
A
Y
V
D
D
M
N
I
I
T
V
L
I
P
A
E
Q
K
E
--
I
M
T
P
P
F
R
L
-
E
T
E
I
T
D
---
F
P
L
A
V
R
E
E
Y
S
L
E
A
K
Y
K
Y
V
C
V
--
S
D
H
P
V
T
F
G
-
K
I
H
C
V
R
A
S
S
G
H
K
---
T
D
L
Q
I
G
A
V
I
R
T
A
A
F
D
D
E
F
Y
Y
D
--
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
---
H
P
N
-
K
-----
S
G
R
T
F
Q
M
T
R
---
L
-
E
K
--
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
----
C
N
N
S
---------------------------
E
W
M
E
T
V
--
D
Q
Y
A
K
A
V
T
----------
V
N
G
E
------------
K
--------------------------
G
------------
V
V
L
R
---
P
D
Q
M
-----
K
----
W
T
A
----
P
-
L
K
P
-
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
-
G
M
---
I
N
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
---
G
V
T
H
V
E
L
L
P
V
N
D
F
A
G
V
D
E
E
----
K
------
P
-------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
----
S
-----
P
F
E
K
T
------------
V
P
-
G
Y
F
F
R
H
D
E
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
------------
T
V
-------------------------------
L
Y
M
K
--------------------------------
E
K
A
T
K
--
A
K
P
G
-----
I
L
L
F
G
E
G
W
D
L
A
T
--
P
-
L
-
P
H
-
E
Q
K
A
A
L
A
N
A
P
R
M
P
--
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
T
-------------
F
H
L
K
-----
A
T
G
F
A
L
G
N
--------
G
E
S
A
---------------
Q
A
V
M
H
G
I
A
G
S
S
------------------
G
W
K
A
--------------
L
A
------------------
P
--
I
--
V
P
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
L
---
P
-
Q
E
-----------------------------
N
D
S
R
K
R
S
R
-
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
G
------------------------------
V
----------------------------------
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
T
---------------------------------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
L
-------------
T
--------
L
--------
K
E
H
L
I
A
Y
R
L
Y
D
L
D
E
-----
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
W
R
L
P
N
----
D
I
----
P
Y
R
L
L
C
D
P
S
G
F
Q
E
D
P
-----------
T
---------------------
E
-
I
K
K
T
V
A
V
N
G
I
G
T
V
I
L
Y
L
A
S
------
3
PsiBlast_PDB
99.14
99%
-85
- C1 -
2E9B
6
PULA_BACSU
A:
[1-712]
M
V
S
I
R
R
S
F
E
A
Y
V
D
D
M
N
I
I
T
V
L
I
P
A
E
Q
K
E
--
I
M
T
P
P
F
R
L
-
E
T
E
I
T
D
---
F
P
L
A
V
R
E
E
Y
S
L
E
A
K
Y
K
Y
V
C
V
--
S
D
H
P
V
T
F
G
-
K
I
H
C
V
R
A
S
S
G
H
K
---
T
D
L
Q
I
G
A
V
I
R
T
A
A
F
D
D
E
F
Y
Y
D
--
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
---
H
P
N
-
K
-----
S
G
R
T
F
Q
M
T
R
---
L
-
E
K
--
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
----
C
N
N
S
---------------------------
E
W
M
E
T
V
--
D
Q
Y
A
K
A
V
T
----------
V
N
G
E
------------
K
--------------------------
G
------------
V
V
L
R
---
P
D
Q
M
-----
K
----
W
T
A
----
P
-
L
K
P
-
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
-
G
M
---
I
N
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
---
G
V
T
H
V
E
L
L
P
V
N
D
F
A
G
V
D
E
E
----
K
------
P
-------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
----
S
-----
P
F
E
K
T
------------
V
P
-
G
Y
F
F
R
H
D
E
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
------------
T
V
-------------------------------
L
Y
M
K
--------------------------------
E
K
A
T
K
--
A
K
P
G
-----
I
L
L
F
G
E
G
W
D
L
A
T
--
P
-
L
-
P
H
-
E
Q
K
A
A
L
A
N
A
P
R
M
P
--
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
T
-------------
F
H
L
K
-----
A
T
G
F
A
L
G
N
--------
G
E
S
A
---------------
Q
A
V
M
H
G
I
A
G
S
S
------------------
G
W
K
A
--------------
L
A
------------------
P
--
I
--
V
P
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
L
---
P
-
Q
E
-----------------------------
N
D
S
R
K
R
S
R
-
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
G
------------------------------
V
----------------------------------
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
T
---------------------------------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
L
-------------
T
--------
L
--------
K
E
H
L
I
A
Y
R
L
Y
D
L
D
E
-----
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
W
R
L
P
N
----
D
I
----
P
Y
R
L
L
C
D
P
S
G
F
Q
E
D
P
-----------
T
---------------------
E
-
I
K
K
T
V
A
V
N
G
I
G
T
V
I
L
Y
L
A
S
------
21
PsiBlast_CBE
99.11
99%
-84
* C1 *
2E9B
3
PULA_BACSU
B:
[1-712]
M
V
S
I
R
R
S
F
E
A
Y
V
D
D
M
N
I
I
T
V
L
I
P
A
E
Q
K
E
--
I
M
T
P
P
F
R
L
-
E
T
E
I
T
D
---
F
P
L
A
V
R
E
E
Y
S
L
E
A
K
Y
K
Y
V
C
V
--
S
D
H
P
V
T
F
G
-
K
I
H
C
V
R
A
S
S
G
H
K
---
T
D
L
Q
I
G
A
V
I
R
T
A
A
F
D
D
E
F
Y
Y
D
--
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
---
H
P
N
-
K
-----
S
G
R
T
F
Q
M
T
R
---
L
-
E
K
--
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
----
C
N
N
S
---------------------------
E
W
M
E
T
V
--
D
Q
Y
A
K
A
V
T
----------
V
N
G
E
------------
K
--------------------------
G
------------
V
V
L
R
---
P
D
Q
M
-----
K
----
W
T
A
----
P
-
L
K
P
-
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
-
G
M
---
I
N
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
---
G
V
T
H
V
E
L
L
P
V
N
D
F
A
G
V
D
E
E
----
K
------
P
-------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
----
S
-----
P
F
E
K
T
------------
V
P
-
G
Y
F
F
R
H
D
E
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
------------
T
V
-------------------------------
L
Y
M
K
--------------------------------
E
K
A
T
K
--
A
K
P
G
-----
I
L
L
F
G
E
G
W
D
L
A
T
--
P
-
L
-
P
H
-
E
Q
K
A
A
L
A
N
A
P
R
M
P
--
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
T
-------------
F
H
L
K
-----
A
T
G
F
A
L
G
N
--------
G
E
S
A
---------------
Q
A
V
M
H
G
I
A
G
S
S
------------------
G
W
K
A
--------------
L
A
------------------
P
--
I
--
V
P
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
L
---
P
-
Q
E
-----------------------------
N
D
S
R
K
R
S
R
-
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
G
------------------------------
V
----------------------------------
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
T
---------------------------------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
L
-------------
T
--------
L
--------
K
E
H
L
I
A
Y
R
L
Y
D
L
D
E
-----
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
W
R
L
P
N
----
D
I
----
P
Y
R
L
L
C
D
P
S
G
F
Q
E
D
P
-----------
T
---------------------
E
-
I
K
K
T
V
A
V
N
G
I
G
T
V
I
L
Y
L
A
S
------
28
Fugue
99.10
99%
-82
- C1 -
2E8Y
3
PULA_BACSU
A:
[1-712]
M
V
S
I
R
R
S
F
E
A
Y
V
D
D
M
N
I
I
T
V
L
I
P
A
E
Q
K
E
--
I
M
T
P
P
F
R
L
-
E
T
E
I
T
D
---
F
P
L
A
V
R
E
E
Y
S
L
E
A
K
Y
K
Y
V
C
V
--
S
D
H
P
V
T
F
G
-
K
I
H
C
V
R
A
S
S
G
H
K
---
T
D
L
Q
I
G
A
V
I
R
T
A
A
F
D
D
E
F
Y
Y
D
--
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
---
H
P
N
-
K
-----
S
G
R
T
F
Q
M
T
R
---
L
-
E
K
--
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
----
C
N
N
S
---------------------------
E
W
M
E
T
V
--
D
Q
Y
A
K
A
V
T
----------
V
N
G
E
------------
K
--------------------------
G
------------
V
V
L
R
---
P
D
Q
M
-----
K
----
W
T
A
----
P
-
L
K
P
-
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
-
G
M
---
I
N
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
---
G
V
T
H
V
E
L
L
P
V
N
D
F
A
G
V
D
E
E
----
K
------
P
-------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
----
S
-----
P
F
E
K
T
------------
V
P
-
G
Y
F
F
R
H
D
E
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
------------
T
V
-------------------------------
L
Y
M
K
--------------------------------
E
K
A
T
K
--
A
K
P
G
-----
I
L
L
F
G
E
G
W
D
L
A
T
--
P
-
L
-
P
H
-
E
Q
K
A
A
L
A
N
A
P
R
M
P
--
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
T
-------------
F
H
L
K
-----
A
T
G
F
A
L
G
N
--------
G
E
S
A
---------------
Q
A
V
M
H
G
I
A
G
S
S
------------------
G
W
K
A
--------------
L
A
------------------
P
--
I
--
V
P
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
L
---
P
-
Q
E
-----------------------------
N
D
S
R
K
R
S
R
-
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
G
------------------------------
V
----------------------------------
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
T
---------------------------------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
L
-------------
T
--------
L
--------
K
E
H
L
I
A
Y
R
L
Y
D
L
D
E
-----
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
W
R
L
P
N
----
D
I
----
P
Y
R
L
L
C
D
P
S
G
F
Q
E
D
P
-----------
T
---------------------
E
-
I
K
K
T
V
A
V
N
G
I
G
T
V
I
L
Y
L
A
S
------
1
PsiBlast_PDB
99.10
99%
-82
- C1 -
2E8Y
3
PULA_BACSU
A:
[1-712]
M
V
S
I
R
R
S
F
E
A
Y
V
D
D
M
N
I
I
T
V
L
I
P
A
E
Q
K
E
--
I
M
T
P
P
F
R
L
-
E
T
E
I
T
D
---
F
P
L
A
V
R
E
E
Y
S
L
E
A
K
Y
K
Y
V
C
V
--
S
D
H
P
V
T
F
G
-
K
I
H
C
V
R
A
S
S
G
H
K
---
T
D
L
Q
I
G
A
V
I
R
T
A
A
F
D
D
E
F
Y
Y
D
--
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
---
H
P
N
-
K
-----
S
G
R
T
F
Q
M
T
R
---
L
-
E
K
--
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
----
C
N
N
S
---------------------------
E
W
M
E
T
V
--
D
Q
Y
A
K
A
V
T
----------
V
N
G
E
------------
K
--------------------------
G
------------
V
V
L
R
---
P
D
Q
M
-----
K
----
W
T
A
----
P
-
L
K
P
-
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
-
G
M
---
I
N
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
---
G
V
T
H
V
E
L
L
P
V
N
D
F
A
G
V
D
E
E
----
K
------
P
-------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
----
S
-----
P
F
E
K
T
------------
V
P
-
G
Y
F
F
R
H
D
E
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
------------
T
V
-------------------------------
L
Y
M
K
--------------------------------
E
K
A
T
K
--
A
K
P
G
-----
I
L
L
F
G
E
G
W
D
L
A
T
--
P
-
L
-
P
H
-
E
Q
K
A
A
L
A
N
A
P
R
M
P
--
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
T
-------------
F
H
L
K
-----
A
T
G
F
A
L
G
N
--------
G
E
S
A
---------------
Q
A
V
M
H
G
I
A
G
S
S
------------------
G
W
K
A
--------------
L
A
------------------
P
--
I
--
V
P
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
L
---
P
-
Q
E
-----------------------------
N
D
S
R
K
R
S
R
-
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
G
------------------------------
V
----------------------------------
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
T
---------------------------------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
L
-------------
T
--------
L
--------
K
E
H
L
I
A
Y
R
L
Y
D
L
D
E
-----
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
W
R
L
P
N
----
D
I
----
P
Y
R
L
L
C
D
P
S
G
F
Q
E
D
P
-----------
T
---------------------
E
-
I
K
K
T
V
A
V
N
G
I
G
T
V
I
L
Y
L
A
S
------
22
PsiBlast_CBE
98.94
99%
-81
- C1 -
2E8Z
4
PULA_BACSU
B:
[1-712]
M
V
S
I
R
R
S
F
E
A
Y
V
D
D
M
N
I
I
T
V
L
I
P
A
E
Q
K
E
--
I
M
T
P
P
F
R
L
-
E
T
E
I
T
D
---
F
P
L
A
V
R
E
E
Y
S
L
E
A
K
Y
K
Y
V
C
V
--
S
D
H
P
V
T
F
G
-
K
I
H
C
V
R
A
S
S
G
H
K
---
T
D
L
Q
I
G
A
V
I
R
T
A
A
F
D
D
E
F
Y
Y
D
--
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
---
H
P
N
-
K
-----
S
G
R
T
F
Q
M
T
R
---
L
-
E
K
--
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
----
C
N
N
S
---------------------------
E
W
M
E
T
V
--
D
Q
Y
A
K
A
V
T
----------
V
N
G
E
------------
K
--------------------------
G
------------
V
V
L
R
---
P
D
Q
M
-----
K
----
W
T
A
----
P
-
L
K
P
-
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
-
G
M
---
I
N
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
---
G
V
T
H
V
E
L
L
P
V
N
D
F
A
G
V
D
E
E
----
K
------
P
-------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
----
S
-----
P
F
E
K
T
------------
V
P
-
G
Y
F
F
R
H
D
E
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
------------
T
V
-------------------------------
L
Y
M
K
--------------------------------
E
K
A
T
K
--
A
K
P
G
-----
I
L
L
F
G
E
G
W
D
L
A
T
--
P
-
L
-
P
H
-
E
Q
K
A
A
L
A
N
A
P
R
M
P
--
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
T
-------------
F
H
L
K
-----
A
T
G
F
A
L
G
N
--------
G
E
S
A
---------------
Q
A
V
M
H
G
I
A
G
S
S
------------------
G
W
K
A
--------------
L
A
------------------
P
--
I
--
V
P
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
L
---
P
-
Q
E
-----------------------------
N
D
S
R
K
R
S
R
-
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
G
------------------------------
V
----------------------------------
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
T
---------------------------------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
L
-------------
T
--------
L
--------
K
E
H
L
I
A
Y
R
L
Y
D
L
D
E
-----
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
W
R
L
P
N
----
D
I
----
P
Y
R
L
L
C
D
P
S
G
F
Q
E
D
P
-----------
T
---------------------
E
-
I
K
K
T
V
A
V
N
G
I
G
T
V
I
L
Y
L
A
S
------
23
PsiBlast_CBE
97.94
99%
-81
- C1 -
2E8Y
3
PULA_BACSU
B:
[1-712]
M
V
S
I
R
R
S
F
E
A
Y
V
D
D
M
N
I
I
T
V
L
I
P
A
E
Q
K
E
--
I
M
T
P
P
F
R
L
-
E
T
E
I
T
D
---
F
P
L
A
V
R
E
E
Y
S
L
E
A
K
Y
K
Y
V
C
V
--
S
D
H
P
V
T
F
G
-
K
I
H
C
V
R
A
S
S
G
H
K
---
T
D
L
Q
I
G
A
V
I
R
T
A
A
F
D
D
E
F
Y
Y
D
--
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
---
H
P
N
-
K
-----
S
G
R
T
F
Q
M
T
R
---
L
-
E
K
--
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
I
----
C
N
N
S
---------------------------
E
W
M
E
T
V
--
D
Q
Y
A
K
A
V
T
----------
V
N
G
E
------------
K
--------------------------
G
------------
V
V
L
R
---
P
D
Q
M
-----
K
----
W
T
A
----
P
-
L
K
P
-
F
----
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
-
G
M
---
I
N
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
---
G
V
T
H
V
E
L
L
P
V
N
D
F
A
G
V
D
E
E
----
K
------
P
-------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
-
Q
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
----
S
-----
P
F
E
K
T
------------
V
P
-
G
Y
F
F
R
H
D
E
C
-
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
------------
T
V
-------------------------------
L
Y
M
K
--------------------------------
E
K
A
T
K
--
A
K
P
G
-----
I
L
L
F
G
E
G
W
D
L
A
T
--
P
-
L
-
P
H
-
E
Q
K
A
A
L
A
N
A
P
R
M
P
--
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
T
-------------
F
H
L
K
-----
A
T
G
F
A
L
G
N
--------
G
E
S
A
---------------
Q
A
V
M
H
G
I
A
G
S
S
------------------
G
W
K
A
--------------
L
A
------------------
P
--
I
--
V
P
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
L
---
P
-
Q
E
-----------------------------
N
D
S
R
K
R
S
R
-
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
G
------------------------------
V
----------------------------------
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
T
---------------------------------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
L
-------------
T
--------
L
--------
K
E
H
L
I
A
Y
R
L
Y
D
L
D
E
-----
V
D
E
W
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
W
R
L
P
N
----
D
I
----
P
Y
R
L
L
C
D
P
S
G
F
Q
E
D
P
-----------
T
---------------------
E
-
I
K
K
T
V
A
V
N
G
I
G
T
V
I
L
Y
L
A
S
------
6
PsiBlast_PDB
73.37
47%
-1
- C1 -
3WDH
1
?
A:
[10-707]
------
S
F
E
A
Y
L
D
E
L
T
M
I
T
I
L
F
P
C
H
V
D
Q
--
K
R
A
P
I
F
F
L
R
D
D
K
K
T
A
---
Y
R
L
T
I
R
S
S
E
K
H
H
S
F
I
K
Y
E
C
L
--
V
P
F
I
V
E
L
G
-
K
R
Y
V
V
Y
T
E
E
G
W
Q
---
V
P
L
Q
V
G
A
V
M
R
T
K
A
F
D
D
L
Y
A
Y
D
--
G
N
D
L
G
A
T
Y
D
P
--
E
--
K
T
T
F
K
V
W
A
P
T
A
T
D
V
L
L
K
L
I
---
H
P
T
T
K
-----
E
E
T
T
Y
V
M
T
R
---
E
-
K
K
--
G
L
W
T
Y
T
V
Y
D
-------
D
-----
V
E
R
F
L
Y
T
Y
M
T
----
Y
V
N
F
---------------------------
I
W
R
E
A
V
--
D
P
Y
A
K
S
V
S
----------
V
N
G
T
------------
Y
--------------------------
G
------------
V
V
V
D
---
L
A
K
T
-----
N
----
I
P
K
----
P
S
M
S
L
-
F
----
I
S
M
T
D
A
I
I
Y
E
M
H
I
R
D
F
T
I
H
H
E
S
-
G
V
---
R
Q
K
G
K
Y
V
G
L
T
E
R
G
T
T
G
P
N
G
T
L
T
G
L
S
Y
I
K
Q
L
---
G
V
T
H
V
Q
L
M
P
V
Q
D
F
E
G
V
D
E
L
----
Q
------
P
-------------------------------------------------------------
L
K
M
Y
N
W
G
Y
N
T
V
H
Y
N
A
P
E
G
S
Y
A
T
D
P
-----
D
D
P
Y
A
R
I
I
E
L
K
R
A
I
R
A
F
Q
-
Q
E
G
I
R
V
I
L
D
V
V
Y
N
H
V
Y
V
R
E
----
T
----
S
-----
S
F
E
H
L
------------
V
P
-
G
Y
Y
F
R
Y
E
R
N
-
G
Y
P
S
N
G
T
G
V
G
N
D
L
A
S
E
R
K
M
V
K
K
F
I
I
D
S
V
T
Y
W
L
K
E
Y
G
V
D
G
F
R
F
D
L
M
G
I
L
D
I
D
------------
T
M
-------------------------------
N
D
V
R
--------------------------------
R
A
I
D
E
--
I
D
P
T
-----
V
I
I
L
G
E
G
W
D
L
A
T
--
P
-
L
-
P
S
-
E
K
K
T
T
I
A
N
A
K
H
T
P
--
R
I
A
Y
F
N
D
R
F
R
D
Y
V
K
G
S
T
-------------
F
D
I
H
-----
E
R
G
F
A
L
G
D
--------
C
S
Y
K
---------------
E
A
V
I
G
A
I
R
G
S
--------------------------------------
I
------------------
H
--
L
--
F
F
S
P
R
Q
S
V
N
Y
V
E
C
H
D
N
H
T
L
W
D
K
M
A
V
A
N
---
A
-
H
E
-----------------------------
S
E
Y
I
R
R
K
R
-
Q
K
L
A
T
A
I
V
L
L
S
Q
G
I
P
F
L
H
S
G
Q
E
F
Y
R
T
K
K
G
------------------------------
V
----------------------------------
E
N
S
Y
N
S
P
D
E
V
N
Q
V
D
W
N
E
K
------
S
R
---------------------------------
W
E
E
D
V
R
E
I
M
K
L
I
E
L
R
K
K
H
G
A
F
R
F
L
T
A
D
Q
V
R
R
H
M
K
F
Y
-------------
D
--------
T
--------
H
P
S
V
I
A
Y
Q
L
V
D
V
G
V
-----
Y
G
P
W
K
Q
I
V
V
V
Y
H
N
E
E
K
K
A
M
L
P
L
A
D
----
G
K
----
W
K
V
M
F
S
S
E
---
L
G
N
V
-----------
C
---------------------
E
---
Q
F
I
E
I
N
G
I
G
A
W
V
L
----------
39
HHSearch
72.64
48%
14
- C1 -
3WDH
1
?
A:
[10-709]
------
S
F
E
A
Y
L
D
E
L
T
M
I
T
I
L
F
P
C
H
V
D
Q
--
K
R
A
P
I
F
F
L
-
R
D
D
K
K
T
A
Y
R
L
T
I
R
S
S
E
K
--
H
H
S
F
I
K
Y
E
C
L
--
V
P
F
I
V
E
L
G
-
K
R
Y
V
V
Y
T
E
E
G
W
Q
---
V
P
L
Q
V
G
A
V
M
R
T
K
A
F
D
D
L
Y
A
Y
D
--
G
N
D
L
G
A
T
Y
D
P
--
E
--
K
T
T
F
K
V
W
A
P
T
A
T
D
V
L
L
K
L
I
---
H
P
T
T
K
-----
E
E
T
T
Y
V
M
T
R
---
E
-
K
K
--
G
L
W
T
Y
T
V
Y
D
-------
D
-----
V
E
R
F
L
Y
T
Y
M
T
----
Y
V
N
F
---------------------------
I
W
R
E
A
V
--
D
P
Y
A
K
S
V
S
----------
V
N
G
T
------------
Y
--------------------------
G
------------
V
V
V
D
---
L
A
K
T
-----
N
----
I
P
K
P
---
S
-
M
S
L
-
F
----
I
S
M
T
D
A
I
I
Y
E
M
H
I
R
D
F
T
I
H
H
E
S
-
G
V
---
R
Q
K
G
K
Y
V
G
L
T
E
R
G
T
T
G
P
N
G
T
L
T
G
L
S
Y
I
K
Q
L
---
G
V
T
H
V
Q
L
M
P
V
Q
D
F
E
G
V
D
E
L
----
Q
------
P
-------------------------------------------------------------
L
K
M
Y
N
W
G
Y
N
T
V
H
Y
N
A
P
E
G
S
Y
A
T
D
P
-----
D
D
P
Y
A
R
I
I
E
L
K
R
A
I
R
A
F
Q
-
Q
E
G
I
R
V
I
L
D
V
V
Y
N
H
V
Y
V
R
E
----
T
----
S
-----
S
F
E
H
L
------------
V
P
-
G
Y
Y
F
R
Y
E
R
N
-
G
Y
P
S
N
G
T
G
V
G
N
D
L
A
S
E
R
K
M
V
K
K
F
I
I
D
S
V
T
Y
W
L
K
E
Y
G
V
D
G
F
R
F
D
L
M
G
I
L
D
I
D
------------
T
M
-------------------------------
N
D
V
R
--------------------------------
R
A
I
D
E
--
I
D
P
T
-----
V
I
I
L
G
E
G
W
D
L
A
T
--
P
-
L
-
P
S
-
E
K
K
T
T
I
A
N
A
K
H
T
P
--
R
I
A
Y
F
N
D
R
F
R
D
Y
V
K
G
S
T
-------------
F
D
I
H
-----
E
R
G
F
A
L
G
D
--------
C
S
Y
K
---------------
E
A
V
I
G
A
I
R
G
S
I
--------------------------------------------------------
H
--
L
--
F
F
S
P
R
Q
S
V
N
Y
V
E
C
H
D
N
H
T
L
W
D
K
M
A
V
A
N
---
A
-
H
E
-----------------------------
S
E
Y
I
R
R
K
R
-
Q
K
L
A
T
A
I
V
L
L
S
Q
G
I
P
F
L
H
S
G
Q
E
F
Y
R
T
K
K
G
------------------------------
V
----------------------------------
E
N
S
Y
N
S
P
D
E
V
N
Q
V
D
W
N
E
K
------
S
R
---------------------------------
W
E
E
D
V
R
E
I
M
K
L
I
E
L
R
K
K
H
G
A
F
R
F
L
T
A
D
Q
V
R
R
H
M
K
F
Y
-------------
D
--------
T
--------
H
P
S
V
I
A
Y
Q
L
V
D
V
G
V
-----
Y
G
P
W
K
Q
I
V
V
V
Y
H
N
E
E
K
K
A
M
L
P
L
A
-----
D
G
----
K
W
K
V
M
F
S
S
E
---
L
G
------------
N
---------------------
V
-
C
E
Q
F
I
E
I
N
G
I
G
A
W
V
L
I
Q
--------
5
PsiBlast_PDB
72.33
47%
-3
- C1 -
3WDI
5
?
A:
[9-707]
-----
Q
S
F
E
A
Y
L
D
E
L
T
M
I
T
I
L
F
P
C
H
V
D
Q
--
K
R
A
P
I
F
F
L
R
D
D
K
K
T
A
---
Y
R
L
T
I
R
S
S
E
K
H
H
S
F
I
K
Y
E
C
L
--
V
P
F
I
V
E
L
G
-
K
R
Y
V
V
Y
T
E
E
G
W
Q
---
V
P
L
Q
V
G
A
V
M
R
T
K
A
F
D
D
L
Y
A
Y
D
--
G
N
D
L
G
A
T
Y
D
P
--
E
--
K
T
T
F
K
V
W
A
P
T
A
T
D
V
L
L
K
L
I
---
H
P
T
T
K
-----
E
E
T
T
Y
V
M
T
R
---
E
-
K
K
--
G
L
W
T
Y
T
V
Y
D
-------
D
-----
V
E
R
F
L
Y
T
Y
M
T
----
Y
V
N
F
---------------------------
I
W
R
E
A
V
--
D
P
Y
A
K
S
V
S
----------
V
N
G
T
------------
Y
--------------------------
G
------------
V
V
V
D
---
L
A
K
T
-----
N
----
I
P
K
----
P
S
M
S
L
-
F
----
I
S
M
T
D
A
I
I
Y
E
M
H
I
R
D
F
T
I
H
H
E
S
-
G
V
---
R
Q
K
G
K
Y
V
G
L
T
E
R
G
T
T
G
P
N
G
T
L
T
G
L
S
Y
I
K
Q
L
---
G
V
T
H
V
Q
L
M
P
V
Q
D
F
E
G
V
D
E
L
----
Q
------
P
-------------------------------------------------------------
L
K
M
Y
N
W
G
Y
N
T
V
H
Y
N
A
P
E
G
S
Y
A
T
D
P
-----
D
D
P
Y
A
R
I
I
E
L
K
R
A
I
R
A
F
Q
-
Q
E
G
I
R
V
I
L
D
V
V
Y
N
H
V
Y
V
R
E
----
T
----
S
-----
S
F
E
H
L
------------
V
P
-
G
Y
Y
F
R
Y
E
R
N
-
G
Y
P
S
N
G
T
G
V
G
N
D
L
A
S
E
R
K
M
V
K
K
F
I
I
D
S
V
T
Y
W
L
K
E
Y
G
V
D
G
F
R
F
D
L
M
G
I
L
D
I
D
------------
T
M
-------------------------------
N
D
V
R
--------------------------------
R
A
I
D
E
--
I
D
P
T
-----
V
I
I
L
G
E
G
W
D
L
A
T
--
P
-
L
-
P
S
-
E
K
K
T
T
I
A
N
A
K
H
T
P
--
R
I
A
Y
F
N
D
R
F
R
D
Y
V
K
G
S
T
-------------
F
D
I
H
-----
E
R
G
F
A
L
G
D
--------
C
S
Y
K
---------------
E
A
V
I
G
A
I
R
G
S
--------------------------------------
I
------------------
H
--
L
--
F
F
S
P
R
Q
S
V
N
Y
V
E
C
H
D
N
H
T
L
W
D
K
M
A
V
A
N
---
A
-
H
E
-----------------------------
S
E
Y
I
R
R
K
R
-
Q
K
L
A
T
A
I
V
L
L
S
Q
G
I
P
F
L
H
S
G
Q
E
F
Y
R
T
K
K
G
------------------------------
V
----------------------------------
E
N
S
Y
N
S
P
D
E
V
N
Q
V
D
W
N
E
K
------
S
R
---------------------------------
W
E
E
D
V
R
E
I
M
K
L
I
E
L
R
K
K
H
G
A
F
R
F
L
T
A
D
Q
V
R
R
H
M
K
F
Y
-------------
D
--------
T
--------
H
P
S
V
I
A
Y
Q
L
V
D
V
G
V
-----
Y
G
P
W
K
Q
I
V
V
V
Y
H
N
E
E
K
K
A
M
L
P
L
A
D
----
G
K
----
W
K
V
M
F
S
S
-----
G
N
V
-----------
C
---------------------
E
---
Q
F
I
E
I
N
G
I
G
A
W
V
L
----------
4
PsiBlast_PDB
70.67
47%
-1
- C1 -
3WDJ
5
?
A:
[11-707]
-------
F
E
A
Y
L
D
E
L
T
M
I
T
I
L
F
P
C
---------
P
I
F
F
L
R
D
D
K
K
T
A
---
Y
R
L
T
I
R
S
S
E
----
F
I
K
Y
E
C
L
--
V
P
F
I
V
E
L
G
-
K
R
Y
V
V
Y
T
E
E
--
Q
---
V
P
L
Q
V
G
A
V
M
R
T
K
A
F
D
D
L
Y
A
Y
D
--
G
N
D
L
G
A
T
Y
D
P
--
E
--
K
T
T
F
K
V
W
A
P
T
A
T
D
V
L
L
K
L
I
---
H
P
T
T
K
-----
E
E
T
T
Y
V
M
T
R
---
E
-
K
K
--
G
L
W
T
Y
T
V
Y
D
-------
D
-----
V
E
R
F
L
Y
T
Y
M
T
----
Y
V
N
F
---------------------------
I
W
R
E
A
V
--
D
P
Y
A
K
S
V
S
----------
V
N
G
T
------------
Y
--------------------------
G
------------
V
V
V
D
---
L
A
K
T
-----
N
----
I
P
K
----
P
S
M
S
L
-
F
----
I
S
M
T
D
A
I
I
Y
E
M
H
I
R
D
F
T
I
H
H
E
S
-
G
V
---
R
Q
K
G
K
Y
V
G
L
T
E
R
G
T
T
G
P
N
G
T
L
T
G
L
S
Y
I
K
Q
L
---
G
V
T
H
V
Q
L
M
P
V
Q
D
F
E
G
V
D
E
L
----
Q
------
P
-------------------------------------------------------------
L
K
M
Y
N
W
G
Y
N
T
V
H
Y
N
A
P
E
G
S
Y
A
T
D
P
-----
D
D
P
Y
A
R
I
I
E
L
K
R
A
I
R
A
F
Q
-
Q
E
G
I
R
V
I
L
D
V
V
Y
N
H
V
Y
V
R
E
----
T
----
S
-----
S
F
E
H
L
------------
V
P
-
G
Y
Y
F
R
Y
E
R
N
-
G
Y
P
S
N
G
T
G
V
G
N
D
L
A
S
E
R
K
M
V
K
K
F
I
I
D
S
V
T
Y
W
L
K
E
Y
G
V
D
G
F
R
F
D
L
M
G
I
L
D
I
D
------------
T
M
-------------------------------
N
D
V
R
--------------------------------
R
A
I
D
E
--
I
D
P
T
-----
V
I
I
L
G
E
G
W
D
L
A
T
--
P
-
L
-
P
S
-
E
K
K
T
T
I
A
N
A
K
H
T
P
--
R
I
A
Y
F
N
D
R
F
R
D
Y
V
K
G
S
T
-------------
F
D
I
H
-----
E
R
G
F
A
L
G
D
--------
C
S
Y
K
---------------
E
A
V
I
G
A
I
R
G
S
--------------------------------------
I
------------------
H
--
L
--
F
F
S
P
R
Q
S
V
N
Y
V
E
C
H
D
N
H
T
L
W
D
K
M
A
V
A
N
---
A
-
H
E
-----------------------------
S
E
Y
I
R
R
K
R
-
Q
K
L
A
T
A
I
V
L
L
S
Q
G
I
P
F
L
H
S
G
Q
E
F
Y
R
T
K
K
G
------------------------------
V
----------------------------------
E
N
S
Y
N
S
P
D
E
V
N
Q
V
D
W
N
E
K
------
S
R
---------------------------------
W
E
E
D
V
R
E
I
M
K
L
I
E
L
R
K
K
H
G
A
F
R
F
L
T
A
D
Q
V
R
R
H
M
K
F
Y
-------------
D
--------
T
--------
H
P
S
V
I
A
Y
Q
L
V
D
V
G
V
-----
Y
G
P
W
K
Q
I
V
V
V
Y
H
N
E
E
K
K
A
M
L
P
L
A
D
----
G
K
----
W
K
V
M
F
S
S
----
L
G
N
V
-----------
C
---------------------
E
---
Q
F
I
E
I
N
G
I
G
A
W
V
L
----------
45
HHSearch
57.74
29%
30
- C1 -
2YA0
7
?
A:
[2-710]
--------------------------------------------------------------------------------------------------------
W
R
L
K
D
E
T
Y
S
Y
D
--
G
-
K
L
G
A
D
L
K
E
EG
K
--
Q
V
D
L
T
L
W
S
P
S
A
D
K
V
S
V
V
V
Y
---
D
K
N
-
D
PDK--
V
V
G
T
V
A
L
E
K
---
G
-
E
R
--
G
T
W
K
Q
T
L
D
S
TNKLGIT
D
-----
F
T
G
Y
Y
Y
Q
Y
Q
I
----
E
R
Q
G
---------------------------
K
T
V
L
A
L
--
D
P
Y
A
K
S
L
A
----------
A
W
N
S
DDSKIDDAHK
V
A
K
--------------------------
A
------------
A
F
V
D
---
P
A
K
L
-----
G
----
P
Q
D
L
T
Y
G
K
-
I
H
N
-
F
----
K
T
R
E
D
A
V
I
Y
E
A
H
V
R
D
F
T
S
D
P
A
I
-
A
K
DLT
K
P
F
G
T
F
E
A
F
I
-----------
E
K
L
D
Y
L
K
D
L
---
G
V
T
H
I
Q
L
L
P
V
L
S
Y
Y
F
V
N
E
L
----
K
------
N
HERLSDYASS---------------------------------------------------
N
S
N
Y
N
W
G
Y
D
P
Q
N
Y
F
S
L
T
G
M
Y
S
S
D
P
-----
K
N
P
E
K
R
I
A
E
F
K
N
L
I
N
E
I
H
-
K
R
G
M
G
A
I
L
D
V
V
Y
N
H
T
A
K
------
V
----
D
-----
L
F
E
D
L
------------
E
P
-
N
Y
Y
H
F
M
D
A
D
-
G
T
P
R
T
S
-
F
G
G
G
R
L
G
T
T
H
H
M
T
K
R
L
L
I
D
S
I
K
Y
L
V
D
T
Y
K
V
D
G
F
R
F
D
M
M
G
D
H
D
A
A
------------
S
I
-------------------------------
E
E
A
Y
--------------------------------
K
A
A
R
A
--
L
N
P
N
-----
L
I
M
L
G
E
G
W
R
T
Y
A
--
G
D
E
-
N
M
P
T
K
A
A
D
Q
D
W
M
K
H
T
D
--
T
V
A
V
F
S
D
D
I
R
N
N
L
K
S
G
Y
-------------
P
N
E
G
-----
Q
P
A
F
I
T
G
G
--------
K
R
D
V
---------------
N
T
I
F
K
N
L
I
A
Q
P
-------------------------------------
T
------------------
N
--
F
E-
A
D
S
P
G
D
V
I
Q
Y
I
A
A
H
D
N
L
T
L
F
D
I
I
A
Q
S
I
---
K
-
K
D
PSK
A
E
------------------------
N
Y
A
E
I
H
R
R
-
L
R
L
G
N
L
M
V
L
T
A
Q
G
T
P
F
I
H
S
G
Q
E
Y
G
R
T
K
Q
F
------------------------------
R
NPAYRTPVAEDKVPNK
S
H
L
L
R
D
KDGNPFDYPYFI
H
D
S
Y
D
S
S
D
A
V
N
K
F
D
W
T
K
A
------
T
D
GKAY
P
E
---------------------------
N
V
K
S
R
D
Y
M
K
G
L
I
A
L
R
Q
S
T
D
A
F
R
L
K
S
L
Q
D
I
K
D
R
V
H
L
I
-------------
T
VPGQNGVE
K
--------
E
D
V
V
I
G
Y
Q
I
T
A
P
N
---------
G
D
I
Y
A
V
F
V
N
A
D
E
K
A
R
E
F
N
L
G
T
AFAH
L
R
----
N
A
E
V
L
A
D
E
N
Q
A
G
P
V
G
IANPKG
L
----
E
---------------------
W
-
T
E
K
G
L
K
L
N
A
L
T
A
T
V
L
R
V
S
Q
N
G
T
S
--
43
HHSearch
55.53
30%
21
- C1 -
2FHF
5
PULA_ENTAE
A:
[271-1072]
----------------------------------------------------------------------------------------------
I
L
S
S
A
T
Q
V
Q
T
A
G
V
L
D
D
T
Y
A
A
A
A
E
A
L
S
Y
G
A
Q
L
T
D
--
S
--
G
V
T
F
R
V
W
A
P
T
A
Q
Q
V
E
L
V
I
Y
---
S
A
D
-
K
K----
V
I
A
S
H
P
M
T
R
---
D
S
A
S
--
G
A
W
S
W
Q
G
G
S
-------
D
-----
L
K
G
A
F
Y
R
Y
A
M
----
T
V
Y
H
PQSRKV---------------------
E
Q
Y
E
V
T
--
D
P
Y
A
H
S
L
S
----------
T
N
S
E
------------
Y
--------------------------
S
------------
Q
V
V
D
---
L
N
D
S
ALKPE
G
----
W
D
G
L---
T
-
M
P
H
-
A
QKT
K
A
D
L
A
K
M
T
I
H
E
S
H
I
R
D
L
S
A
W
D
Q
T
-
V
P
A--
E
L
R
G
K
Y
L
A
L
T
A
Q
E
S
----
N
M
V
Q
H
L
K
Q
L
S
A
S
---
G
V
T
H
I
E
L
L
P
V
F
D
L
A
T
V
N
E
F
----
S
------
D
KVADIQQP
F
S
R
L
C
E
V
N
SAVKSSEFAGYCDSGST
V
E
E
V
L
T
Q
L
KQNDSKDNP
Q
V
Q
A
L
N
T
L
V
A
Q
T
D
S
Y
N
W
G
Y
D
P
F
H
Y
T
V
P
E
G
S
Y
A
T
D
P
------
E
G
T
A
R
I
K
E
F
R
T
M
I
Q
A
I
K
Q
D
L
G
M
N
V
I
M
D
V
V
Y
N
H
T
N
A
A
-----
G
----
P
TDRTS
V
L
D
K
I
------------
V
P
-
W
Y
Y
Q
R
L
N
E
T
T
G
S
V
E
S
A
T
-
C
C
S
D
S
A
P
E
H
R
M
F
A
K
L
I
A
D
S
L
A
V
W
T
T
D
Y
K
I
D
G
F
R
F
D
L
M
L
Y
H
P
K
A
------------
Q
I
-------------------------------
L
S
A
W
--------------------------------
E
R
I
K
A
--
L
N
P
D
-----
I
Y
F
F
G
E
G
W
D
S
N
Q
--
S
-
D
--
R
-
F
E
I
A
S
Q
I
N
L
K
-
G
T
--
G
I
G
T
F
S
D
R
L
R
D
A
V
R
G
G
G
P------------
F
D
S
G
D
A
L
R
Q
N
Q
G
V
G
S
G
A
--------
G
V
L
P
NELTTLS
D
D
Q
A
R
H
L
A
D
L
T
R
L
G
M
A
G
N
L
AD
F
V
L
I
D
KDG
A
V
K
R
GSEI
D
Y
N
G
A-------------
P
G
------------------
G
--
Y
--
A
A
D
P
T
E
V
V
N
Y
V
S
K
H
D
N
Q
T
L
W
D
M
I
S
Y
K
A
---
A
Q
E
A
-----------------------------
D
L
D
T
R
V
R
M
-
Q
A
V
S
L
A
T
V
M
L
G
Q
G
I
A
F
D
Q
Q
G
S
E
L
L
R
S
K
S
F
------------------------------
T
----------------------------------
R
D
S
Y
D
S
G
D
W
F
N
R
V
D
Y
S
L
Q
------
D
N
NYNVGMPRSSDDGSN
Y
D
I
I
A
R
V
KDAVATPG
E
T
E
L
K
Q
M
T
A
F
Y
Q
E
L
T
A
L
R
K
S
S
P
L
F
T
L
G
D
G
A
T
V
M
K
R
V
D
F
R
-------------
N
--------
T
GADQ----
Q
T
G
L
L
V
M
T
I
D
D
G
M
Q
AGASL
D
S
R
V
D
G
I
V
V
A
I
N
A
A
P
E
S
R
T
L
Q
D
F
A
----
G
T
----
S
L
Q
L
S
A
I
Q
Q
A
A
G
D
R
S
LASG
V
Q
-----
V
---------------------
A
-
A
D
G
S
V
T
L
P
A
W
S
V
A
V
L
E
L
P
Q
G
E
----
30
Fugue
53.52
27%
3
- C1 -
3FAW
9
?
A:
[37-814]
---
Q
V
Q
L
K
D
A
Q
Q
T
D
L
T
S
I
Q
A
S
F
T
T
L
D
K
T
--
E
I
L
K
E
L
K
V
-
T
D
--
K
N
---
Q
N
A
I
Q
I
S
D
I
T
L
D
T
S
K
S
L
L
I
I
--
K
G
D
F
N
P
K
Q
-
G
H
F
N
I
S
Y
N
--------
G
N
N
V
T
T
R
Q
S
W
E
F
K
D
Q
L
Y
A
Y
S
--
G
-
N
L
G
A
V
L
N
Q
--
D
GS
K
V
E
A
S
L
W
S
P
S
A
D
S
V
T
M
I
I
Y
D
KD
N
Q
N
-
R
-----
V
V
A
T
T
P
L
V
K
---
N
-
N
K
--
G
V
W
Q
T
I
L
D
T
-------
K
LGIKN
Y
T
G
Y
Y
Y
L
Y
E
I
----
K
R
G
K
---------------------------
D
K
V
K
I
L
--
D
P
Y
A
K
S
L
A
EWDSNTVNDD
I
K
T
A
------------
K
--------------------------
A
------------
A
F
V
N
---
P
S
Q
L
-----
G
PQNL
S
F
A
----
K
-
I
A
N
-
F
----
K
G
R
Q
D
A
V
I
Y
E
A
H
V
R
D
F
T
S
D
Q
S
L
-
D
-----------
G
K
L
K
N
Q
L
G
T
F
A
A
F
S
E
K
L
D
Y
L
Q
K
L
---
G
V
T
H
I
Q
L
L
P
V
L
S
Y
F
Y
V
N
E
M
----
D
------
K
SRSTAYTSS----------------------------------------------------
D
N
N
Y
N
W
G
Y
D
P
Q
S
Y
F
A
L
S
G
M
Y
S
E
K
P
-----
K
D
P
S
A
R
I
A
E
L
K
Q
L
I
H
D
I
H
-
K
R
G
M
G
V
I
L
D
V
V
Y
N
H
T
A
K
------
T
----
Y
-----
L
F
E
D
I
------------
E
P
-
N
Y
Y
H
F
M
N
E
D
-
G
S
P
R
E
S
F
G
-
G
G
R
L
G
T
T
H
A
M
S
R
R
V
L
V
D
S
I
K
Y
L
T
S
E
F
K
V
D
G
F
R
F
D
M
M
G
D
H
D
A
A
------------
A
I
-------------------------------
E
L
A
Y
--------------------------------
K
E
A
K
A
--
I
N
P
N
-----
M
I
M
I
G
E
G
W
R
T
F
Q
G
D
Q
-
G
-
K
P
-
V
K
P
A
D
Q
D
W
M
K
S
T
D
--
T
V
G
V
F
S
D
D
I
R
N
S
L
K
S
G
F
-------------
P
N
E
G
-----
T
P
A
F
I
T
G
G
--------
P
Q
S
L
---------------
Q
G
I
F
K
N
I
K
A
Q
P
------------------
G
------------------
N
------------------
F
--
E
--
A
D
S
P
G
D
V
V
Q
Y
I
A
A
H
D
N
L
T
L
H
D
V
I
A
K
S
I
NKD
P
-
K
V
-----------------------------
A
E
E
D
I
H
R
R
-
L
R
L
G
N
V
M
I
L
T
S
Q
G
T
A
F
I
H
S
G
Q
E
Y
G
R
T
K
R
L
LNPDYMTKVSDDKLPNKATLIEAVKEYPYF
I
----------------------------------
H
D
S
Y
D
S
S
D
A
I
N
H
F
D
W
A
A
A
TDNNKH
P
I
---------------------------------
S
T
K
T
Q
A
Y
T
A
G
L
I
T
L
R
R
S
T
D
A
F
R
K
L
S
K
A
E
I
D
R
E
V
S
L
I
-------------
T
--------
E
VGQGDIKE
K
D
L
V
I
A
Y
Q
T
I
D
---------
S
K
G
D
I
Y
A
V
F
V
N
A
D
S
K
A
R
N
V
L
L
G
E
----
K
Y
K
H
L
L
K
G
Q
V
I
V
D
A
D
Q
A
G
I
K
P
-----------
I
---------------------
S
-
T
P
R
G
V
H
F
E
K
D
S
L
L
I
D
P
L
T
A
I
V
I
K
V
G
40
HHSearch
53.48
27%
25
- C1 -
3FAW
9
?
A:
[37-814]
---
Q
V
Q
L
K
D
A
Q
Q
T
D
L
T
S
I
Q
A
S
F
T
T
L
D
--K
T
E
I
L
K
E
L
K
V
-
T
D
K
N
Q
N
A
--
I
Q
I
S
D
I
T
----
L
D
T
S
K
S
L
L
I
--
I
K
G
D
F
N
P
K
Q
G
H
F
N
I
S
Y
N
G
N
N
V
--------
T
T
R
Q
S
W
E
F
K
D
Q
L
Y
A
Y
S
--
G
-
N
L
G
A
V
L
N
Q
DG
S
--
K
V
E
A
S
L
W
S
P
S
A
D
S
V
T
M
I
I
Y
---
D
K
D
-
N
QNR--
V
V
A
T
T
P
L
V
K
---
N
-
N
K
--
G
V
W
Q
T
I
L
D
T
KLGIK--
N
-----
Y
T
G
Y
Y
Y
L
Y
E
I
----
K
R
G
K
---------------------------
D
K
V
K
I
L
--
D
P
Y
A
K
S
L
A
----------
E
W
D
S
NTVNDDIK
T
A
--
K
--------------------------
A
------------
A
F
V
N
---
P
S
Q
L
-----
G
----
P
Q
N
LSFA
K
-
I
A
N
-
F
----
K
G
R
Q
D
A
V
I
Y
E
A
H
V
R
D
F
T
S
D
Q
S
L
-
D
G
KLK
N
Q
L
G
T
F
A
A
F
S
-----------
E
K
L
D
Y
L
Q
K
L
---
G
V
T
H
I
Q
L
L
P
V
L
S
Y
F
Y
V
N
E
M
----
D
------
K
SRSTAYTSS----------------------------------------------------
D
N
N
Y
N
W
G
Y
D
P
Q
S
Y
F
A
L
S
G
M
Y
S
E
K
P
-----
K
D
P
S
A
R
I
A
E
L
K
Q
L
I
H
D
I
H
-
K
R
G
M
G
V
I
L
D
V
V
Y
N
H
T
A
K
------
T
----
Y
-----
L
F
E
D
I
------------
E
P
-
N
Y
Y
H
F
M
N
E
D
-
G
S
P
R
E
S
F
G
-
G
G
R
L
G
T
T
H
A
M
S
R
R
V
L
V
D
S
I
K
Y
L
T
S
E
F
K
V
D
G
F
R
F
D
M
M
G
D
H
D
A
A
------------
A
I
-------------------------------
E
L
A
Y
--------------------------------
K
E
A
K
A
--
I
N
P
N
-----
M
I
M
I
G
E
G
W
R
T
F
Q
--
G
-
D
Q
G
K
P
V
K
P
A
D
Q
D
W
M
K
S
T
D
--
T
V
G
V
F
S
D
D
I
R
N
S
L
K
S
G
F
-------------
P
N
E
G
-----
T
P
A
F
I
T
G
G
--------
P
Q
S
L
---------------
Q
G
I
F
K
N
I
K
A
Q
P
-------------------------------------
G
------------------
N
--
F
E-
A
D
S
P
G
D
V
V
Q
Y
I
A
A
H
D
N
L
T
L
H
D
V
I
A
K
S
I
---
N
-
K
D
PKV--------------------------
A
E
E
D
I
H
R
R
-
L
R
L
G
N
V
M
I
L
T
S
Q
G
T
A
F
I
H
S
G
Q
E
Y
G
R
T
K
R
L
LNPDYMTKVSDDKLPNKATLIEAVKEYPYF
I
----------------------------------
H
D
S
Y
D
S
S
D
A
I
N
H
F
D
W
A
A
A
------
T
D
NNKH
P
I
---------------------------
S
T
K
T
Q
A
Y
T
A
G
L
I
T
L
R
R
S
T
D
A
F
R
K
L
S
K
A
E
I
D
R
E
V
S
L
I
-------------
T
EVGQGDIK
E
--------
K
D
L
V
I
A
Y
Q
T
I
D
S
K
---------
G
D
I
Y
A
V
F
V
N
A
D
S
K
A
R
N
V
L
L
G
E
KY
K
H
L
L
----
K
G
Q
V
I
V
D
A
D
Q
A
G
I
K
P
ISTPRG
V
----
H
---------------------
F
-
E
K
D
S
L
L
I
D
P
L
T
A
I
V
I
K
V
G
-------
17
PsiBlast_PDB
51.99
30%
6
- C1 -
4J3W
6
?
A:
[77-731]
-------------------------------------
L
-
Q
P
E
S
A
G
---
L
P
E
T
V
T
Q
K
F
P
F
I
S
S
Y
R
A
F
R
V
P
S
S
V
D
V
A
S
L
V
-
K
C
Q
L
V
V
A
S
F
---V
D
V
T
G
L
Q
L
P
G
V
L
-----
D
D
M
F
A
Y
T
--
G
-
P
L
G
A
V
F
S
E
--
D
--
S
V
S
L
H
L
W
A
P
T
A
Q
G
V
S
V
C
F
----
F
D
G
-
P
-----
A
G
P
A
L
E
T
V
Q
---
L
-
K
E
S
N
G
V
W
S
V
T
G
P
R
-------
E
-----
W
E
N
R
Y
Y
L
Y
E
V
D
V
Y
H
P
T
K
A
---------------------------
Q
V
L
K
C
L
A
G
D
P
Y
A
R
S
L
S
----------
A
N
G
A
------------
R
TWLVDIN-------------------
N
------------
E
T
L
K
---
P
A
S
W
-----
D
----
E
L
A
----
D
-
E
K
P
K
L
----
D
S
F
S
D
I
T
I
Y
E
L
H
I
R
D
F
S
A
H
D
G
T
V
D
S
---
D
S
R
G
G
F
R
A
F
-------
A
Y
Q
A
S
A
G
M
E
H
L
R
K
L
S
D
A
G
L
T
H
V
H
L
L
P
S
F
H
F
A
G
V
D
D
I
----
K
------
S
N
W
K
F
V
D
E
C
E
L
A
T
FPPGSD
M
Q
Q
A
A
V
V
A
I
Q
E--------------------------------
E
D
P
Y
N
W
G
Y
N
P
V
L
W
G
V
P
K
G
S
Y
A
S
D
P
-----
D
G
P
-
S
R
I
I
E
Y
R
Q
M
V
Q
A
L
N
-
R
I
G
L
R
V
V
M
D
V
V
Y
N
H
L
D
S
S
G
PCGI
S
----
S
-----
V
L
D
K
I
------------
V
P
-
G
Y
Y
V
R
R
D
T
N
-
G
Q
I
E
N
S
A
A
M
-
N
N
T
A
S
E
H
F
M
V
D
R
L
I
V
D
D
L
L
N
W
A
V
N
Y
K
V
D
G
F
R
F
D
L
M
G
H
I
M
K
R
------------
T
M
-------------------------------
M
R
A
K
S
A
L
-----------------------------
Q
S
L
T
T
--
D
A
H
G
VDGSK
I
Y
L
Y
G
A
G
W
D
F
A
E
----
V
-
A
R
-
N
Q
R
G
I
N
G
S
Q
L
N
M
S
GT
G
I
G
S
F
N
D
R
I
R
D
A
I
N
G
G
N
PFGNPLQQGFNTG
L
F
L
E
-----
P
N
G
F
Y
Q
G
N
EA
D
T
R
R
S
L
A
T
Y
A
---------------
D
Q
I
Q
I
G
L
A
G
N
L
------------------
R
D
Y
V
--------------
L
I
SHTG
E
A
K
K
GSEIHTFDGL
P
--
V
G
Y
T
A
S
P
I
E
T
I
N
Y
V
S
A
H
D
N
E
T
L
F
D
V
I
S
V
K
T
---
P
-
M
I
-----------------------------
L
S
V
D
E
R
C
R
I
N
H
L
A
S
S
M
M
A
L
S
Q
G
I
P
F
F
H
A
G
D
E
I
L
R
S
K
S
I
------------------------------
D
----------------------------------
R
D
S
Y
N
S
G
D
W
F
N
K
L
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
51.51
30%
4
- C1 -
4J3U
16
?
A:
[77-731]
-------------------------------------
L
-
Q
P
E
S
A
G
---
L
P
E
T
V
T
Q
K
F
P
F
I
S
S
Y
R
A
F
R
V
P
S
S
V
D
V
A
S
L
V
-
K
C
Q
L
V
V
A
S
F
---D
V
-
T
G
L
Q
L
P
G
V
L
-----
D
D
M
F
A
Y
T
--
G
-
P
L
G
A
V
F
S
E
--
D
--
S
V
S
L
H
L
W
A
P
T
A
Q
G
V
S
V
C
F
----
F
D
G
-
P
-----
A
G
P
A
L
E
T
V
Q
---
L
-
K
E
S
N
G
V
W
S
V
T
G
P
R
-------
E
-----
W
E
N
R
Y
Y
L
Y
E
V
D
V
Y
H
P
T
K
A
---------------------------
Q
V
L
K
C
L
A
G
D
P
Y
A
R
S
L
S
----------
A
N
G
A
------------
R
TWLVDIN-------------------
N
------------
E
T
L
K
---
P
A
S
W
-----
D
----
E
L
A
----
D
-
E
K
P
K
L
----
D
S
F
S
D
I
T
I
Y
E
L
H
I
R
D
F
S
A
H
D
G
T
V
D
S
---
D
S
R
G
G
F
R
A
F
-------
A
Y
Q
A
S
A
G
M
E
H
L
R
K
L
S
D
A
G
L
T
H
V
H
L
L
P
S
F
H
F
A
G
V
D
D
I
----
K
------
S
N
W
K
F
V
D
E
C
E
L
A
T
FPPGSD
M
Q
Q
A
A
V
V
A
I
Q
E--------------------------------
E
D
P
Y
N
W
G
Y
N
P
V
L
W
G
V
P
K
G
S
Y
A
S
D
P
-----
D
G
P
-
S
R
I
I
E
Y
R
Q
M
V
Q
A
L
N
-
R
I
G
L
R
V
V
M
D
V
V
Y
N
H
L
D
S
S
G
PCGI
S
----
S
-----
V
L
D
K
I
------------
V
P
-
G
Y
Y
V
R
R
D
T
N
-
G
Q
I
E
N
S
A
A
M
-
N
N
T
A
S
E
H
F
M
V
D
R
L
I
V
D
D
L
L
N
W
A
V
N
Y
K
V
D
G
F
R
F
D
L
M
G
H
I
M
K
R
------------
T
M
-------------------------------
M
R
A
K
S
A
L
-----------------------------
Q
S
L
T
T
--
D
A
H
G
VDGSK
I
Y
L
Y
G
E
G
W
D
F
A
E
----
V
-
A
R
-
N
Q
R
G
I
N
G
S
Q
L
N
M
S
GT
G
I
G
S
F
N
D
R
I
R
D
A
I
N
G
G
N
PFGNPLQQGFNTG
L
F
L
E
-----
P
N
G
F
Y
Q
G
N
E
A
D
T
R
R
S
L
A
T
Y
A
---------------
D
Q
I
Q
I
G
L
A
G
N
L
------------------
R
D
Y
V
--------------
L
I
SHTG
E
A
K
K
GSEIHTFDGL
P
--
V
G
Y
T
A
S
P
I
E
T
I
N
Y
V
S
A
H
D
N
E
T
L
F
D
V
I
S
V
K
T
---
P
-
M
I
-----------------------------
L
S
V
D
E
R
C
R
I
N
H
L
A
S
S
M
M
A
L
S
Q
G
I
P
F
F
H
A
G
D
E
I
L
R
S
K
S
I
------------------------------
D
----------------------------------
R
D
S
Y
N
S
G
D
W
F
N
K
L
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
51.43
26%
3
- C1 -
1BF2
1
ISOA_PSEAY
A:
[6-749]
-----------------------------------------------------------------------------------------------------------------------
S
L
G
A
S
Y
D
A
--
Q
QA
N
I
T
F
R
V
Y
S
S
Q
A
T
R
I
V
L
Y
L
Y
---
S
A
G
-
Y
GVQ--
E
S
A
T
Y
T
L
S
P
---
A
-
G
S
--
G
V
W
A
V
T
V
P
V
S
S
I
K
A
A
G
I
-----
T
G
A
V
Y
Y
G
Y
R
A
----
W
G
P
N
WPYASNWGKGSQAGFVSDVDANGDRFN
P
N
K
L
L
L
--
D
P
Y
A
Q
E
V
S
----------
Q
D
P
L
------------
N
PSNQNGNVFASGASYRTTDSGIY
A
P
K
G
------------
V
V
L
V
---
P
S
-------
T
----
Q
S
T
G---
T
-
K
P
T
------
R
A
Q
K
D
D
V
I
Y
E
V
H
V
R
G
F
T
E
Q
D
T
S
-
I
P
A--
Q
Y
R
G
T
Y
Y
G
A
G
-----------
L
K
A
S
Y
L
A
S
L
---
G
V
T
A
V
E
F
L
P
V
Q
E
T
Q
N
D
A
N
D
VVPN
S
------
D
-------------------------------------------------------------
A
N
Q
N
Y
W
G
Y
M
T
E
N
Y
F
S
P
D
R
R
Y
A
Y
N
K
-----
A
A
G
-
G
P
T
A
E
F
Q
A
M
V
Q
A
F
H
-
N
A
G
I
K
V
Y
M
D
V
V
Y
N
H
T
A
E
G
-----
G
----
T
-----
W
T
S
S
D
PT
T
A
T
I
Y
S
WRGL
D
N
A
T
Y
Y
E
L
T
S
G
N
-
Q
Y
F
Y
D
N
T
G
I
G
A
N
F
N
T
Y
N
T
V
A
Q
N
L
I
V
D
S
L
A
Y
W
A
N
T
M
G
V
D
G
F
R
F
D
L
A
S
V
L
G
N
S
------------
C
L
NGAYTASAPNCPNGG
Y
N
F
D
AADSNV
A
I
N
R
I
L
R
E
F
T
--------------------------------
V
R
P
A
A
--
G
G
S
G
-----
L
D
L
F
A
E
P
W
A
I
G
G
--
N
-
S
-
Y
Q
--
L
G
-
G
--
F
---
P
Q
--
G
W
S
E
W
N
G
L
F
R
D
S
L
R
Q
A
Q
-------------
N
E
L
G
S----
M
T
I
Y
V
T
Q
------------------------------
D
A
N
D
F
S
G
S
S
------------------
N
L
F
----------------
Q
------------------
S
--
S
--
G
R
S
P
W
N
S
I
N
F
I
D
V
H
D
G
M
T
L
K
D
V
Y
S
C
N
G
---
A
-
N
N
SQAWPYGPSDGGTSTNYSWDQGMSAGTG-
A
A
V
D
Q
R
R
A
-
A
R
T
G
M
A
F
E
M
L
S
A
G
T
P
L
M
Q
G
G
D
E
Y
L
R
T
L
Q
C
------------------------------
N
----------------------------------
N
N
A
Y
N
L
D
S
S
A
N
W
L
T
Y
S
W
T
------
T
D
---------------------------------
Q
S
N
F
Y
T
F
A
Q
R
L
I
A
F
R
K
A
H
P
A
L
R
P
S
S
W
Y
S
G
S
-
Q
L
T
W
Y
Q
PSGAVAD
S
N
Y
W
N
N
--------
T
--------
S
N
Y
A
I
A
Y
A
I
N
G
P
S
L
------
G
D
S
N
S
I
Y
V
A
Y
N
G
W
S
S
S
V
T
F
T
L
P
A
PPS-
G
T
----
Q
W
Y
R
V
T
D
T
C
D
W
N
D
G
A
STFVAPGSETL
I
---------------------
G
G
A
G
T
T
Y
G
Q
C
G
Q
S
L
L
L
L
I
S
--------
47
HHSearch
51.27
26%
11
- C1 -
4J7R
-
?
A:
[96-868]
-----------------------------------------------------------------------------------------------------------------
R
P
--
A
-
P
L
G
A
S
I
D
A
DT
G
--
A
I
N
F
S
V
F
S
S
S
A
E
S
V
S
L
V
L
F
---
T
E
A
-
D
L
N
A
GR
A
T
F
E
I
P
L
D
P
YVN
R
-
T
G
--
D
V
W
H
I
M
L
P
D
-------
L
-----
R
D
D
L
L
Y
G
Y
R
V
----
E
G
V
H
QEEDKDYPG
M
R
H
D
--------------
K
R
R
V
V
L
--
D
P
Y
A
V
A
V
L
----------
N
R
R
R
WGQMGPNLPYGE
E
--------------------------
G
V
L
G
V
M
PTW
P
Q
A
A
A
A
L
P
AAR
G
S
A
F
-----
D
----
W
E
G
----
D
-
T
P
L
-
N
----
L
P
M
E
S
L
V
I
Y
E
A
H
V
R
G
F
T
A
H
A
S
S
-
G
V
---
A
A
P
G
T
Y
A
G
M
V
-----------
E
R
L
D
Y
L
K
S
L
---
G
V
N
A
I
E
L
L
P
V
F
E
F
N
E
L
E
Y
Y
----
S
Q
I
PGSD
Q
-------------------------------------------------------------
Y
R
F
N
F
W
G
Y
S
T
V
N
Y
F
S
P
M
G
R
F
S
A
A
V
G
Q
GAP
A
R
A
--
S
C
D
E
F
K
Q
L
V
K
E
C
H
-
R
R
G
I
E
V
I
L
D
V
V
F
N
H
T
A
E
G
N
----
E
RGPT
I
-----
S
F
R
G
L
------------
D
N
-
R
V
Y
Y
M
L
A
P
G
-
G
E
Y
Y
N
Y
S
G
C
G
N
T
L
N
C
N
Q
P
V
V
R
Q
F
I
L
D
C
L
K
H
W
V
T
E
Y
H
V
D
G
F
R
F
D
L
A
S
I
L
T
R
A
H
S
A
W
H
P
QQYDQE
T
G
-------------------------------
Q
R
V
A
M
SSGGAIVTAEGIMTDGAGVPTGYPLADP
P
L
V
E
S
I
S
E
DP
V
L
R
N
-----
T
K
M
I
A
E
A
W
D
C
D
G
--
L
-
N
-
Q
---
V
G
A
F
P
H
---
Y
G
G
--
R
W
S
E
W
N
G
K
F
R
D
V
V
R
N
F
I
-------------
K
G
T
D
-----
G
-
P
W
---------------
A
---------------
G
D
F
A
S
A
I
C
G
S
P
------------------
N
I
Y
A
NNTPHETDWWANNG
G
R
------------------
Q
WK
G
--
G
R
G
P
H
A
S
I
N
F
V
A
A
H
D
G
F
T
L
A
D
M
V
A
Y
N
N
---
K
-
H
N
EANGENNRDGEQHNNSWNCGEEGPTTK
W
E
V
N
R
L
R
Q
R
Q
-
M
R
N
L
T
G
A
L
L
L
S
C
G
V
P
M
I
N
M
G
D
E
Y
G
H
S
K
N
G
------------------------------
N
----------------------------------
N
N
T
Y
C
H
D
S
E
L
N
Y
L
R
W
D
Q
L
------
A
E
D--------------------------------
P
H
G
F
N
R
F
V
R
L
L
I
H
F
R
R
A
T
P
A
L
Q
R
T
T
F
V
N
D
-
K
D
I
Q
W
H
G
ELPNTPDW----
T
--------
D
--------
T
S
R
L
V
A
F
T
L
H
D
G
K
---------
G
G
G
L
Y
V
A
F
N
T
S
H
L
P
K
L
L
Q
L
P
K
WG--
G
R
----
V
W
Q
P
L
V
D
T
S
K
V
A
P
Y
D
F----------
L
AVDGVLS
A
E
D
V
A
A
A
R
R
Q
M
A
M
W
T
-
A
D
H
T
Y
P
V
L
P
W
S
C
I
V
L
Q
S
A
P
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D
P
---