@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu33440: (2016-07-26 )
MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSAQEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSMSDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDSSYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAAPAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDSLGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQAAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPARLYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQNFKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEWQNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAHDVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY
Atome Classification :
(73 SA)
.........10........20........30........40........50........60........70........80........90.........100.....---..---110-..----..-----.-----.-..--120.......130.......140.---------------......150.......160.......170.......180....--..--.190--..--.--.....200.......210.-....---------------.---------------.220--.----.--.-----.---------------.---------------...230------------------------.-----------........240.......250.......260....-..-.270.......280.......290.......-----------300------.--....------------------...310--------------------.--.------.-----....320...------..-..330........340.----...---...--350-.---........360.-----.-----.--.--.--....370.......380.......390.......400-...---......410------...---.---..---.--420---......-.430.......-----440---...--......450....-....460.......470...-----..-----..480-.-..-----.----..-----.----.----.490.......500.......510......--.520....----..-.----530--.........540...-.....-550...-.....560........570.......580.......590.......600...--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Q
L
Q
VMNSPF
N
Q
E
Q
A
E
L
L
N
R
L
L
P
TLTES
Q
K
I
W
L
S
G
YLSAQSVS
A
Q
EAAGTPAAAVSAEAPAPAVS
K
E
V
T
V
L
Y
GSQTGNAQG
L
A
E
N
A
G
K
Q
L
-
E
QSG
F
Q
V
T
V
S
SMSDFK
P
---
N
Q
---
L
K
--
K
V
----T
N
-----
L
-----
L
-
I
V
--
V
STHGEGEPPD
N
A
L
S
F
H
E
F
L
HGRR---------------AP
K
L
E
D
L
R
F
S
V
L
A
LGDS
S
Y
E
F
F
C
Q
T
G
K
E
F
D
Q
R
L
E
E
LGGKRISP--RV--DCD---LD--Y--DE
P
A
A
E
W
L
E
G
V
L
K
G
L
N
EAG-GGSA---------------A---------------PA-P--A----A--A-----S---------------Q---------------TGES--------------------------S-----------YSRTN
P
F
R
A
E
V
L
E
NLNLNGRGSNK
E
T
R
H
V
E
L
S
LEG-SG-LTYEPGDSLGVYPEN
D
P
E
L
V
E
L
L
L
K
EMNW
D
P
-----------
E
E
-------
I
--
V
T
LN------------------KQGD
V
R
--------------------
P
--
L
------
K
-----
E
A
L
ISH
Y
E
I
T
------
V
L
-
T
K
P
L
-
L
E
Q
A
A
Q
LTG
N
D
E
----
L
R
E
---
L
LA--P---G---
N
E
E
N
V
K
A
Y
I--E-----G-----
R
--
D
--
L
--
L
D
L
V
R
DYGPFSV
S
A
Q
E
F
V
S
I
L
R
KM
P
A
R
L
Y
S
I
A
S
S
L---SAN---P
D
E
V
H
L
T
I
G
------
A
V
R
---Y---DA---H--GRE---RK
G
V
C
S
-
I
L
C
A
E
RLQPGD-----
T
-----
L
P
V
--
Y
V
QHNQN-FKLPK-DPET
P
I
I
M
VGPGTG
V
A
P
F
R
S
-----
F
M
-----
Q
E
R
---
E
-ET-----G----AE-----G----
K
----
A
W
M
F
FGD
Q
H
F
V
T
D
F
L
Y
Q
T
E
W
Q
N
W
L
K
DGVL
T
--
K
M
D
V
AFSR----DT-
E
----
E
----
K
V
Y
V
Q
H
R
M
L
E
H
-
S
A
E
-
L
F
E
W
L
-QE-G
A
A
-
V
Y
I
CGDE-
K
H
M
A
H
D
V
H
N
T
L
L
E
I
I
E
KEGNM
S
R
E
E
A
E
A
Y
L
A
D
M
Q
Q
Q
K
R
Y
QRDVY--
100
Fugue
80.20
32%
39
- C2 -
1JA1
4
NCPR_RAT
A:
[7-622]
--------------------------------------------------
P
V
K
E
S
S
F
V
E
K
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
----
P
E
IDK
S
L
V
-----
V
-
F
C
--
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
----------------
V
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
L
G
L
G
--
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
C
E
F
F
-
G
V
E
A
---------------
T
---------------
G
E
-
E
--
S
----
S
--
I
-----
R
---------------
Q
---------------
Y
E
L
V
V
H
EDMDVAKVYTGEMGRLKSYENQKP
P
-----------
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
------------------
N
L
D
E
E
S
NKKHPFPCPT----------
T
--
Y
------
R
-----
T
A
L
T
Y
Y
L
D
I
T
N-----
P
P
-
R
T
N
V
-
L
Y
E
L
A
Q
Y
A
S
E
P
S
----
E
Q
E
---
H
L
H
--
K
---
M
ASS
S
G
E
G
K
E
L
Y
L
--
S
WVVEA
R
-----
R
--
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
A
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
G
E
NGGRA
L
-----
V
P
M
--
F
V
R
K
S
-
Q
-
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
---
A
-
W
L
-----
R
----
E
Q
-----
G
----
K
E
V
G
E
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
H
E
G
-
G
A
H
-
I
Y
V
A
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
N
V
W
S-
5
PsiBlast_PDB
79.90
31%
39
- C2 -
3FJO
2
NCPR_HUMAN (first)
A:
[38-636]
----------------------------------------------------------------
N
K
N
Y
L
V
L
Y
A
S
Q
T
G
T
A
E
D
Y
A
K
K
F
S
K
E
L
V
A
K
F
N
L
N
V
M
C
A
D
V
E
N
Y
D
F
---
E
S
---
L
N
--
D
V
----
P
V
-----
I
-----
V
S
I
F
--
I
S
T
Y
G
E
G
D
F
P
D
G
A
V
N
F
E
D
F
I
C
N
A
E
---------------
A
G
A
L
S
N
L
R
Y
N
M
F
G
L
G
N
S
T
Y
E
F
F
N
G
A
A
K
K
A
E
K
H
L
S
A
A
G
A
I
R
L
G
K
--
L
G
--
E
A
D
DGA
G
T
--
T
--
D
E
D
Y
M
A
W
K
D
S
I
L
E
V
L
K
D
E
L
-
G
V
E
A
---------------
T
GEESSIRQ
Y
E
L
V
V
HT
D
I
-
D
--
A
----
A
--
K
-----
V
---------------
Y
---------------
M
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
G
A
D
L
-----------
D
V
-------
V
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTS
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
---
L
A
Q
Y
A
S
E
P
S
E
Q
E
----
L
L
R
---
K
M
A
--
S
---
S
---
S
G
E
G
K
E
L
Y
L
--
S
WVVEA
R
-----
R
--
H
--
I
--
L
A
I
L
Q
D
C
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
V
V
E
---
Y
---
E
T
---
K
A-
G
R
I
---
N
K
G
V
A
T
-
N
W
L
R
A
K
E
P
A
--------R
A
L
--
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
A
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
Q
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
------------
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
-
R
E
H
-
L
W
K
L
I
-
E
G
-
G
A
H
-
I
Y
V
C
G
D
A
-
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
110
HHSearch
79.82
31%
17
- C2 -
1TLL
4
NOS1_RAT
A:
[9-654]
--------------------------------------------------------------
A
K
R
V
K
A
T
I
L
Y
A
T
E
T
G
K
S
Q
A
Y
A
K
T
L
C
E
I
F
-
K
-
H
A
F
D
A
K
A
M
S
M
E
E
Y
D
I
---
V
H
---
L
E
--
H
E
----
A
L
-----
V
-----
L
-
V
V
--
T
S
T
F
G
N
G
D
P
P
E
N
G
E
K
F
G
C
A
L
M
E
M
R
HE
E
R
K
S
YKVRFNSVS-
G
P
L
A
N
V
R
F
S
V
F
G
L
G
S
R
A
Y
P
H
F
C
A
F
G
H
A
V
D
T
L
L
E
E
L
G
G
E
R
I
L
K
--
M
R
--
E
G
D
---
E
L
CG
Q
--
E
E
A
F
R
T
W
A
K
K
V
F
K
A
A
C
D
V
F
C
V
G
D
D
---------------
V
---------------
N
I
E----SN--
D
--
R
SWKRN
K
F
R
L
T
Y
V
AEAPD
L
---
T
---------------
Q
G
L
S
--------------------------
N
-----------
V
H
K
K
R
V
S
A
A
R
L
L
S
R
Q
N
L
Q
S
P
K
S
S
R
S
T
I
F
V
R
L
H
T
N
G
N
Q
E
-
L
Q
Y
Q
P
G
D
H
L
G
V
F
P
G
N
H
E
D
L
V
N
A
L
I
E
R
L
E
D
A
P
-----------
P
A
-------
N
HV
V
K
V
E
M
L
E
E
R
N
T
AL
G
V
I
S
N
W
K
D
E
S
R
L
P
P
C
--------------------
T
--
I
------
F
-----
Q
A
F
K
Y
Y
L
D
I
T
------
T
P
P
T
P
L
Q
-
L
Q
Q
F
A
S
L
A
T
N
E
K
E
K
Q
R
L
L
V
---
L
S
-------
K
---
G
L
Q
E
Y
E
E
W
K
W
G
K
-----
N
-----
P
--
T
--
M
--
V
E
V
L
E
E
F
P
S
I
Q
M
P
A
T
L
L
L
T
Q
L
S
L
L
Q
P
R
Y
Y
S
I
S
S
S
P
---
D
M
Y
---
P
D
E
V
H
L
T
V
A
------
I
V
S
---
Y
---
H
T
RDG
E
--
G
P
V
---
H
H
G
V
C
S
-
S
W
L
N
R
-
I
Q
A
D
D
-----
V
-----
V
P
C
--
F
V
R
G
A
P
S
-
F
H
L
P
R
-
N
P
Q
V
P
C
I
L
V
G
P
G
T
G
I
A
P
F
R
S
-----
F
W
-----
Q
Q
R
---
Q
-
F
D
I
Q
HKG
M
----
N
P
-----
C
----
P
----
M
V
L
V
F
G
C
R
Q
S
K
I
D
H
I
Y
R
E
E
T
L
Q
A
K
N
K
G
V
F
R
--
E
L
Y
T
A
Y
S
R
----
E
P
-
D
R---
P
----
K
K
Y
V
Q
D
V
L
Q
E
Q
L
A
E
S
-
V
Y
R
A
L
K
E
Q
-
G
G
H
-
I
Y
V
C
G
D
V
-
T
-
M
A
A
D
V
L
K
A
I
Q
R
I
M
T
Q
Q
G
K
L
S
E
E
D
A
G
V
F
I
S
R
L
R
D
D
N
R
Y
H
E
D
I
F
--
109
HHSearch
79.65
32%
34
- C2 -
3QE2
4
NCPR_HUMAN
A:
[12-617]
----------------------------------------------------------
E
K
M
K
K
T
G
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
LSS
L
P
EI
D
N
----
A
L
-----
V
-----
V
-
F
C
--
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
----------------
V
D
L
S
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
K
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
--
L
G
D
---
D
D
--
G
N
L
E
E
D
F
I
T
W
R
E
Q
F
W
L
A
V
C
E
H
F
G
V
E
A
T
----------------------------------
S
SI
R
Q
Y
E
L
V
V
H
T
DI---
D
AAKVYMGEMGRLKSY
E
---------------
N
Q
K
P
--------------------------
P
-----------
F
D
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
Q
G
-
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
G
A
D
L
-----------
D
V
-------
V
--
M
S
L
N
N
LDEESNKKH--------
P
F
P
C
P
T
--------------------
S
--
Y
------
R
-----
T
A
L
T
Y
Y
L
D
I
T
------
N
P
P
R
T
N
V
-
L
Y
E
L
A
Q
Y
A
S
E
P
S
E
Q
E
L
L
R
K
---
M
A
S
SS
G
---
E
---
G
K
E
L
Y
L
S
W
V
VE
A
-----
R
-----
R
--
H
--
I
--
L
A
I
L
Q
D
C
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
V
V
E
---
Y
---
E
T
K--
A
--
G
R
I
---
N
K
G
V
A
T
-
N
W
L
R
A
K
E
P
V
--R
A
---
L
-----
V
P
M
--
F
V
-
R
K
S
Q
-
F
R
L
P
F
-
K
A
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
---
A
-
W
L
-----
R
Q
Q
G
K
E
V
-----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
S
----
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
-
R
E
H
-
L
W
K
L
I
-
E
G
-
G
A
H
-
I
Y
V
C
G
D
A
R
N
-
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
31
PsiBlast_CBE
79.47
31%
37
- C2 -
1JA1
4
NCPR_RAT
B:
[22-621]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
----
P
E
-----
I
DK
S
L
V
V
-
F
C
--
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
L
G
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
C
E
F
F
-
G
V
E
A
---------------
T
---------------
G
E
-
E
--
S
----
S
--
I
-----
R
---------------
Q
Y
E
L
V
V
H
EDMDVAKVY
T
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTT
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
E
H
----
L
H
K
---
M
A
S
--
S
SG
E
G
---
K
E
L
Y
L
S
W
V
V
--
E
-----
A
-----
R
R-
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
A
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
G
E
-----
N
GG
R
A
L
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
E
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
-
H
E
-
G
G
A
H
I
Y
V
A
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
N
V
W
--
16
PsiBlast_PDB
79.37
31%
38
- C2 -
1JA1
4
NCPR_RAT
A:
[22-621]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
----
P
E
-----
I
DK
S
L
V
V
-
F
C
--
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
L
G
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
C
E
F
F
-
G
V
E
A
---------------
T
---------------
G
E
-
E
--
S
----
S
--
I
-----
R
---------------
Q
Y
E
L
V
V
H
EDMDVAKVY
T
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTT
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
E
H
----
L
H
K
---
M
A
S
--
S
SG
E
G
---
K
E
L
Y
L
S
W
V
V
--
E
-----
A
-----
R
R-
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
A
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
G
E
-----
N
GGRA
L
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
E
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
-
H
E
-
G
G
A
H
I
Y
V
A
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
N
V
W
--
18
PsiBlast_PDB
79.30
31%
34
- C2 -
4YAU
5
?
A:
[22-620]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
PEID
K
S
-----
L
-----
V
-
V
F
--
C
M
A
T
Y
N
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
L
G
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
C
E
F
F
-
G
V
E
A
---------------
T
---------------------
S
----
S
--
I
-----
R
---------------
Q
Y
E
L
V
V
H
EDMDVAKVY
T
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTT
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
E
H
----
L
H
K
---
M
A
S
--
S
SG
E
G
---
K
E
L
Y
L
S
W
V
V
--
E
-----
A
-----
R
R-
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
G
-------RAL--
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
E
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
-
H
E
-
G
G
A
H
I
Y
V
C
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
9
PsiBlast_PDB
79.04
31%
47
- C2 -
3OJW
2
NCPR_RAT
A:
[22-621]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
----
P
E
-----
I
DK
S
L
V
V
-
F
A
--
M
A
T
Y
G
E
G
D
P
T
C
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
L
G
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
A
E
F
F
-
G
V
E
A
---------------
T
---------------
G
E
-
E
--
S
----
S
--
I
-----
R
---------------
Q
Y
E
L
V
V
H
EDMDVAKVY
T
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PTPTT
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
E
H
----
L
H
K
---
M
A
S
--
S
S
G
E
G
---
K
E
L
Y
L
S
W
V
V
--
E
-----
A
-----
R
R-
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
L
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
T
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
G
-------
R
A
L
--
V
P
M
--
F
V
C
K
S
Q
--
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
E
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
A
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
-
H
E
-
G
G
A
H
I
Y
V
C
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
11
PsiBlast_PDB
78.98
31%
34
- C2 -
3QE2
4
NCPR_HUMAN
A:
[19-617]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
ADL
S
S
---
L
P
--
E
I
----
D
N
-----
A
-----
L
-
V
V
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
S
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
K
R
L
E
Q
L
G
A
Q
R
I
F
E
L
G
L
G
--
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
L
A
V
C
E
H
F
-
G
V
E
A
TSSIRQ
Y
E
L
V
V
H---
T
---------------
D
I
-
D
--
A
----
A
--
K
-----
V
---------------
Y
---------------
M
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
G
A
D
L
-----------
D
V
-------
V
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTS
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
---
L
A
Q
Y
A
S
E
P
S
E
Q
E
----
L
L
R
---
K
M
A
--
S
---
S
---
S
G
E
G
K
E
L
Y
L
--
S
-----
W
VVEAR
R
--
H
--
I
--
L
A
I
L
Q
D
C
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
V
V
E
---
Y
---
E
T
---
K
A-
G
R
I
---
N
K
G
V
A
T
-
N
W
L
R
A
K
E
P
V
--------R
A
L
--
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
A
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
Q
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
S
----
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
-
R
E
H
-
L
W
K
L
I
-
E
G
-
G
A
H
-
I
Y
V
C
G
D
A
-
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
10
PsiBlast_PDB
78.95
31%
44
- C2 -
3OJX
3
NCPR_RAT
A:
[22-621]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
----
P
E
-----
I
DK
S
L
V
V
-
F
A
--
M
A
T
Y
G
E
G
D
P
T
C
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
L
G
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
A
E
F
F
-
G
V
E
A
---------------
T
---------------
G
E
-
E
--
S
----
S
--
I
-----
R
---------------
Q
Y
E
L
V
V
H
EDMDVAKVY
T
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PTPTT
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
E
H
----
L
H
K
---
M
A
S
--
S
S
G
E
G
---
K
E
L
Y
L
S
W
V
V
--
E
-----
A
-----
R
R-
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
L
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
T
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
--------R
A
L
--
V
P
M
--
F
V
C
K
S
Q
--
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
E
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
A
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
-
H
E
-
G
G
A
H
I
Y
V
C
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
17
PsiBlast_PDB
78.92
31%
39
- C2 -
4Y7C
3
?
A:
[22-620]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
PEID
K
S
-----
L
-----
V
-
V
F
--
C
M
A
T
Y
N
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
L
G
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
C
E
F
F
-
G
V
E
A
---------------
T
----------------
E
-
E
--
S
----
S
--
I
-----
R
---------------
Q
Y
E
L
V
V
H
EDMDVAKVY
T
G
E
M
--------------------------
G
RLKSYE
N
Q
K
P
P
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTT
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
E
H
----
L
H
K
---
M
A
S
--
S
SG
E
G
---
K
E
L
Y
L
S
W
V
V
--
E
-----
A
-----
R
R-
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
G
-------RA
L
--
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
E
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
-
H
E
-
G
G
A
H
I
Y
V
C
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
32
PsiBlast_CBE
78.90
31%
36
- C2 -
4YAU
6
?
B:
[22-620]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
PEID
K
S
-----
L
-----
V
-
V
F
--
C
M
A
T
Y
N
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
L
G
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
C
E
F
F
-
G
V
E
A
---------------
T
-----------------------------
I
-----
R
---------------
Q
Y
E
L
V
V
H
EDMDVAKVY
T
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
NLDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTT
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
E
H
----
L
H
K
---
M
A
S
--
S
SG
E
G
---
K
E
L
Y
L
S
W
V
V
--
E
-----
A
-----
R
R-
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
G
-------RA
L
--
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
E
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
-
H
E
-
G
G
A
H
I
Y
V
C
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
19
PsiBlast_PDB
78.73
31%
41
- C2 -
4Y9U
3
?
A:
[22-620]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
----
P
E
-----
I
DK
S
L
V
V
-
F
C
--
M
A
T
Y
----
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
L
G
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
C
E
F
F
-
G
V
E
A
---------------
T
----------------
E
-
E
--
S
----
S
--
I
-----
R
---------------
Q
Y
E
L
V
V
H
EDMDVAKVY
T
G
E
M
--------------------------
G
RLKSYE
N
Q
K
P
P
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTT
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
E
H
----
L
H
K
---
M
A
S
--
S
SG
E
G
---
K
E
L
Y
L
S
W
V
V
--
E
-----
A
-----
R
R-
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
G
-------
R
A
L
--
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
E
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
-
H
E
-
G
G
A
H
I
Y
V
C
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
27
PsiBlast_CBE
78.59
31%
52
- C2 -
3QE2
4
NCPR_HUMAN
B:
[19-617]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
ADL
S
S
---
L
P
--
E
I
----
D
N
-----
A
-----
L
-
V
V
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
S
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
K
R
L
E
Q
L
G
A
Q
R
I
F
E
L
G
L
G
--
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
L
A
V
C
E
H
F
-
G
V
E
A
TRQ
Y
E
L
V
V
H
------
T
---------------
D
I
-
D
--
A
----
A
--
K
-----
V
---------------
Y
---------------
M
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
G
A
D
L
-----------
D
V
-------
V
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTS
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
---
L
A
Q
Y
A
S
E
P
S
E
Q
E
----
L
L
R
---
K
M
A
--
S
---
S
---
S
G
E
G
K
E
L
Y
L
--
S
-----
W
VVEAR
R
--
H
--
I
--
L
A
I
L
Q
D
C
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
V
V
E
---
Y
---
E
T
---
K
A-
G
R
I
---
N
K
G
V
A
T
-
N
W
L
R
A
K
E
P
V
G
E
-----
N
GGRA
L
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
A
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
Q
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
S
----
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
-
R
E
H
-
L
W
K
L
I
-
E
G
-
G
A
H
-
I
Y
V
C
G
D
A
-
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
33
PsiBlast_CBE
78.51
31%
35
- C2 -
4Y7C
4
?
B:
[22-620]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
PEID
K
S
-----
L
-----
V
-
V
F
--
C
M
A
T
Y
N
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
L
G
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
C
E
F
F
-
G
V
E
A
---------------
T
-----------------------------
I
-----
R
---------------
Q
Y
E
L
V
V
H
EDMDVAKVY
T
G
E
M
--------------------------
G
RLKSYE
N
Q
K
P
P
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTT
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
E
H
----
L
H
K
---
M
A
S
--
S
SG
E
G
---
K
E
L
Y
L
S
W
V
V
--
E
-----
A
-----
R
R-
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
G
-------R
A
L
--
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
E
Q
-----
G
----
K
E
V----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
-
H
E
-
G
G
A
H
I
Y
V
C
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
28
PsiBlast_CBE
78.47
31%
45
- C2 -
3QFR
3
NCPR_HUMAN
B:
[19-617]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
ADL
S
S
---
L
P
--
E
I
----
D
N
-----
A
-----
L
-
V
V
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
S
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
K
R
L
E
Q
L
G
A
Q
R
I
F
E
L
G
L
G
--
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
C
E
H
F
-
G
V
E
A
T
GSSIRQ
Y
E
L
V
V
H
--
T
---------------
D
I
-
D
--
A
----
A
--
K
-----
V
---------------
Y
---------------
M
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
G
A
D
L
-----------
D
V
-------
V
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTS
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
---
L
A
Q
Y
A
S
E
P
S
E
Q
E
----
L
L
R
---
K
M
A
--
S
---
S
---
S
G
E
G
K
E
L
Y
L
--
S
-----
W
VVEAR
R
--
H
--
I
--
L
A
I
L
Q
D
C
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
H
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
V
V
E
---
Y
---
E
T
---
K
A-
G
R
I
---
N
K
G
V
A
T
-
N
W
L
R
A
K
E
P
---------RAL--
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
A
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
Q
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
S
----
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
-
R
E
H
-
L
W
K
L
I
-
E
G
-
G
A
H
-
I
Y
V
C
G
D
A
-
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
25
PsiBlast_CBE
78.27
31%
46
- C2 -
1J9Z
3
NCPR_RAT
B:
[22-620]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
----
P
E
-----
I
DK
S
L
V
V
-
F
C
--
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
L
G
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
C
E
F
F
-
G
V
E
A
---------------
T
---------------
G
E
-
E
--
S
----
S
--
I
-----
R
---------------
Q
Y
E
L
V
V
H
EDMDVAKVY
T
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTT
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
E
H
----
L
H
K
---
M
A
S
--
S
SG
E
G
---
K
E
L
Y
L
S
W
V
V
--
E
-----
A
-----
R
R-
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
G
-------RA
L
--
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
E
Q
-----
G
----
K
E
V----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
-
H
E
-
G
G
A
H
I
Y
V
C
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
---
20
PsiBlast_PDB
78.14
31%
40
- C2 -
4YAO
5
?
A:
[22-620]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
----
P
E
-----
I
DK
S
L
V
V
-
F
C
--
M
A
T
Y
---
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
L
G
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
C
E
F
F
-
G
V
E
A
---------------------------------------------------
R
---------------
Q
Y
E
L
V
V
H
EDMDVAKVY
T
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
NLDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTT
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
E
H
----
L
H
K
---
M
A
S
--
S
SG
E
G
---
K
E
L
Y
L
S
W
V
V
--
E
-----
A
-----
R
R-
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
--------R
A
L
--
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
E
Q
-----
G
----
K
E
V----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
-
H
E
-
G
G
A
H
I
Y
V
C
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
23
PsiBlast_CBE
77.97
31%
46
- C2 -
4YAL
5
?
B:
[22-621]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
----
P
E
-----
I
DK
S
L
V
V
-
F
C
--
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
L
G
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
C
E
F
F
-
G
V
E
A
---------------
T
-----------------------------
I
-----
R
---------------
Q
Y
E
L
V
V
H
E
DMDVAKVY
T
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
NLDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTT
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
E
H
----
L
H
K
---
M
A
S
--
S
SG
E
G
---
K
E
L
Y
L
S
W
V
V
--
E
-----
A
-----
R
R-
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
G
-------RA
L
--
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
E
Q
-----
G
----
K
E
V----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
-
H
E
-
G
G
A
H
I
Y
V
C
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
14
PsiBlast_PDB
77.93
31%
38
- C2 -
4YAW
6
?
A:
[22-620]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
---
A
D
---
L
S
--
S
L
PEID
K
S
-----
L
-----
V
-
V
F
--
C
M
A
T
Y
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
T
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
Q
R
L
E
Q
L
G
A
Q
R
I
F
E
--
L
G
L
G
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
P
A
V
C
E
F
F
-
G
V
E
A
---------------
T
---------------------
S
----
S
--
I
-----
R
---------------
Q
Y
E
L
V
V
H
E
DMDVAKVY
T
G
E
M
--------------------------
G
RLKSYE
N
Q
K
P
P
F
D
A
K
N
P
F
L
A
A
V
T
A
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
I
G
E
I
L
G
A
D
L
-----------
D
V
-------
I
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTT
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
-
L
-
A
Q
Y
A
S
E
P
S
E
Q
E
H
----
L
H
K
---
M
A
S
--
S
SG
E
G
---
K
E
L
Y
L
S
W
V
V
--
E
-----
A
-----
R
R-
H
--
I
--
L
A
I
L
Q
D
Y
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
A
V
E
---
Y
---
E
A
---
K
S-
G
R
V
---
N
K
G
V
A
T
-
S
W
L
R
A
K
E
P
A
G
-------RA
L
--
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
S
T
T
P
V
I
M
V
G
P
G
T
G
I
A
P
F
M
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
E
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
R
F
H
K
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
A
----
H
----
K
V
Y
V
Q
H
L
L
K
R
D
-
R
E
H
-
L
W
K
L
I
-
H
E
-
G
G
A
H
I
Y
V
C
G
D
A
-
R
N
M
A
K
D
V
Q
N
T
F
Y
D
I
V
A
E
F
G
P
M
E
H
T
Q
A
V
D
Y
V
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
15
PsiBlast_PDB
77.33
31%
47
- C2 -
3QFC
4
NCPR_HUMAN
A:
[19-617]
-----------------------------------------------------------------
R
N
I
I
V
F
Y
G
S
Q
T
G
T
A
E
E
F
A
N
R
L
S
K
D
A
-
H
R
Y
G
M
R
G
M
S
A
D
P
E
E
Y
D
L
ADL
S
S
---
L
P
--
E
I
----
D
N
-----
A
-----
L
-
V
V
F
C
M
A
T
Y
G
E
G
D
P
T
D
N
A
Q
D
F
Y
D
W
L
Q
E
T
D
---------------
V
-
D
L
S
G
V
K
F
A
V
F
G
L
G
N
K
T
Y
E
H
F
N
A
M
G
K
Y
V
D
K
R
L
E
Q
L
G
A
Q
R
I
F
E
L
G
L
G
--
D
D
D
---
G
N
--
L
--
E
E
D
F
I
T
W
R
E
Q
F
W
L
A
V
C
E
H
F
-
G
V
E
A
TGEESSIRQ
Y
E
L
V
V
H
T
---------------
D
I
-
D
--
A
----
A
--
K
-----
V
---------------
Y
---------------
M
G
E
M
--------------------------
G
RLKSYENQKPP
F
D
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
G
A
D
L
-----------
D
V
-------
V
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTS
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
---
L
A
Q
Y
A
S
E
P
S
E
Q
E
----
L
L
R
---
K
M
A
--
S
---
S
---
S
G
E
G
K
E
L
Y
L
--
S
-----
W
VVEAR
R
--
H
--
I
--
L
A
I
L
Q
D
C
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
V
V
E
---
Y
---
E
T
---
K
A-
G
R
I
---
N
K
G
E
A
T
-
N
W
L
R
A
K
E
P
V
--------R
A
L
--
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
A
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
Q
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
S
----
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
-
R
E
H
-
L
W
K
L
I
-
E
G
-
G
A
H
-
I
Y
V
C
G
D
A
-
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
1
PsiBlast_PDB
76.19
46%
-105
- C2 -
1DDG
1
CYSJ_ECOLI
A:
[4-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------
P
-----------
Y
S
K
D
A
P
L
V
A
S
L
S
V
N
Q
K
I
T
G
R
N
S
E
K
D
V
R
H
I
E
I
D
L
G
D
-
S
G
-
L
R
Y
Q
P
G
D
A
L
G
V
W
Y
Q
N
D
P
A
L
V
K
E
L
V
E
L
L
W
L
K
G
-----------
D
E
-------
P
--
V
T
V
--------------------
E
G
K
T
L
--------------------
P
--
L
------
N
-----
E
A
L
Q
W
H
F
E
L
T
------
V
N
-
T
A
N
I
-
V
E
N
Y
A
T
L
T
R
S
E
T
----
L
L
P
---
L
V
-------
G
---
D
K
A
K
L
Q
H
Y
A
--
A
-----
T
-----
T
--
P
--
I
--
V
D
M
V
R
-
F
S
P
A
Q
L
D
A
E
A
L
I
N
L
L
R
P
L
T
P
R
L
Y
S
I
A
S
S
Q
---
A
E
V
---
E
N
E
V
H
V
T
V
G
------
V
V
R
---
Y
---
D
V
---
E
--
G
R
A
---
R
A
G
G
A
S
-
S
F
L
A
D
R
V
E
E
E
G
-----
E
-----
V
R
V
--
F
I
E
H
N
D
N
-
F
R
L
P
A
-
N
P
E
T
P
V
I
M
I
G
P
G
T
G
I
A
P
F
R
A
-----
F
M
-----
Q
Q
R
---
A
-
A
D
-----
E
----
A
P
-----
G
----
K
----
N
W
L
F
F
G
N
P
H
F
T
E
D
F
L
Y
Q
V
E
W
Q
R
Y
V
K
E
G
V
L
T
--
R
I
D
L
A
W
S
R
----
D
Q
-
K
----
E
----
K
V
Y
V
Q
D
K
L
R
E
Q
-
G
A
E
-
L
W
R
W
I
-
N
D
-
G
A
H
-
I
Y
V
C
G
D
A
-
N
R
M
A
K
D
V
E
Q
A
L
L
E
V
I
A
E
F
G
G
M
D
T
E
A
A
D
E
F
L
S
E
L
R
V
E
R
R
Y
Q
R
D
V
Y
--
21
PsiBlast_CBE
75.64
46%
-100
- C2 -
1DDG
2
CYSJ_ECOLI
B:
[4-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------
P
-----------
Y
S
K
D
A
P
L
V
A
S
L
S
V
N
Q
K
I
T
G
R
N
S
E
K
D
V
R
H
I
E
I
D
L
G
D
-
S
G
-
L
R
Y
Q
P
G
D
A
L
G
V
W
Y
Q
N
D
P
A
L
V
K
E
L
V
E
L
L
W
L
K
G
-----------
D
E
-------
P
--
V
T
V
--------------------
E
G
K
T
L
--------------------
P
--
L
------
N
-----
E
A
L
Q
W
H
F
E
L
T
------
V
N
-
T
A
N
I
-
V
E
N
Y
A
T
L
T
R
S
E
T
----
L
L
P
---
L
V
-------
G
---
D
K
A
K
L
Q
H
Y
A
--
A
-----
T
-----
T
--
P
--
I
--
V
D
M
V
R
-
F
S
P
A
Q
L
D
A
E
A
L
I
N
L
L
R
P
L
T
P
R
L
Y
S
I
A
S
S
Q
---
A
E
V
---
E
N
E
V
H
V
T
V
G
------
V
V
R
---
Y
---
D
V
---
E
--
G
R
A
---
R
A
G
G
A
S
-
S
F
L
A
D
R
V
E
E
E
G
-----
E
-----
V
R
V
--
F
I
E
H
N
D
N
-
F
R
L
P
A
-
N
P
E
T
P
V
I
M
I
G
P
G
T
G
I
A
P
F
R
A
-----
F
M
-----
Q
Q
R
---
A
-
A
D
-----
E
----
A
P
-----
G
----
K
----
N
W
L
F
F
G
N
P
H
F
T
E
D
F
L
Y
Q
V
E
W
Q
R
Y
V
K
E
G
V
L
T
--
R
I
D
L
A
W
S
R
----
D
Q
-
K
----
E
----
K
V
Y
V
Q
D
K
L
R
E
Q
-
G
A
E
-
L
W
R
W
I
-
N
D
-
G
A
H
-
I
Y
V
C
G
D
A
-
N
R
M
A
K
D
V
E
Q
A
L
L
E
V
I
A
E
F
G
G
M
D
T
E
A
A
D
E
F
L
S
E
L
R
V
E
R
R
Y
Q
R
D
V
Y
--
113
HHSearch
75.51
46%
-94
- C2 -
1DDG
1
CYSJ_ECOLI
A:
[4-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------
P
-----------
Y
S
K
D
A
P
L
V
A
S
L
S
V
N
Q
K
I
T
G
R
N
S
E
K
D
V
R
H
I
E
I
D
L
G
D
-
S
G
-
L
R
Y
Q
P
G
D
A
L
G
V
W
Y
Q
N
D
P
A
L
V
K
E
L
V
E
L
L
W
L
K
G
-----------
D
E
-------
P
--
V
T
V
E
--------------------
G
K
T
L
--------------------
P
--
L
------
N
-----
E
A
L
Q
W
H
F
E
L
T
------
V
N
-
T
A
N
I
-
V
E
N
Y
A
T
L
T
R
S
E
T
----
L
L
P
---
L
V
G
----------
D
K
A
K
L
Q
H
Y
A
--
A
-----
T
-----
T
--
P
--
I
--
V
D
M
V
R
-
F
S
P
A
Q
L
D
A
E
A
L
I
N
L
L
R
P
L
T
P
R
L
Y
S
I
A
S
S
Q
---
A
E
V
---
E
N
E
V
H
V
T
V
G
------
V
V
R
---
Y
---
D
V
---
E
--
G
R
A
---
R
A
G
G
A
S
-
S
F
L
A
D
R
V
E
E
E
G
-----
E
-----
V
R
V
--
F
I
E
H
N
D
N
-
F
R
L
P
A
-
N
P
E
T
P
V
I
M
I
G
P
G
T
G
I
A
P
F
R
A
-----
F
M
-----
Q
Q
R
---
A
-
A
D
-----
E
----
A
P
-----
G
----
K
----
N
W
L
F
F
G
N
P
H
F
T
E
D
F
L
Y
Q
V
E
W
Q
R
Y
V
K
E
G
V
L
T
--
R
I
D
L
A
W
S
R
----
D
Q
-
K
----
E
----
K
V
Y
V
Q
D
K
L
R
E
Q
-
G
A
E
-
L
W
R
W
I
-
N
D
-
G
A
H
-
I
Y
V
C
G
D
A
N
R
-
M
A
K
D
V
E
Q
A
L
L
E
V
I
A
E
F
G
G
M
D
T
E
A
A
D
E
F
L
S
E
L
R
V
E
R
R
Y
Q
R
D
V
Y
--
2
PsiBlast_PDB
75.15
46%
-100
- C2 -
1DDI
2
CYSJ_ECOLI
A:
[4-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------
P
-----------
Y
S
K
D
A
P
L
V
A
S
L
S
V
N
Q
K
I
T
G
R
N
S
E
K
D
V
R
H
I
E
I
D
L
G
D
-
S
G
-
L
R
Y
Q
P
G
D
A
L
G
V
W
Y
Q
N
D
P
A
L
V
K
E
L
V
E
L
L
W
L
K
G
-----------
D
E
-------
P
--
V
T
V
--------------------
E
G
K
T
L
--------------------
P
--
L
------
N
-----
E
A
L
Q
W
H
F
E
L
T
------
V
N
-
T
A
N
I
-
V
E
N
Y
A
T
L
T
R
S
E
T
----
L
L
P
---
L
V
-------
G
---
D
K
A
K
L
Q
H
Y
A
--
A
-----
T
-----
T
--
P
--
I
--
V
D
M
V
R
-
F
S
P
A
Q
L
D
A
E
A
L
I
N
L
L
R
P
L
T
P
R
L
Y
S
I
A
S
S
Q
---
A
E
V
---
E
N
E
V
H
V
T
V
G
------
V
V
R
---
Y
---
D
V
---
E
--
G
R
A
---
R
A
G
G
A
S
-
S
F
L
A
D
R
V
E
E
E
G
-----
E
-----
V
R
V
--
F
I
E
H
N
D
N
-
F
R
L
P
A
-
N
P
E
T
P
V
I
M
I
G
P
G
T
G
I
A
P
F
R
A
-----
F
M
-----
Q
Q
R
---
A
-
A
D
-----
E
----
A
P
-----
G
----
K
----
N
W
L
F
F
G
N
P
H
F
T
E
D
F
L
Y
Q
V
E
W
Q
R
Y
V
K
E
G
V
L
T
--
R
I
D
L
A
W
S
R
----
D
Q
-
K
----
E
----
K
V
Y
V
Q
D
K
L
R
E
Q
-
G
A
E
-
L
W
R
W
I
-
N
D
-
G
A
H
-
I
Y
V
C
G
D
A
-
N
R
M
A
K
D
V
E
Q
A
L
L
E
V
I
A
E
F
G
G
M
D
T
E
A
A
D
E
F
L
S
E
L
R
V
E
R
R
Y
Q
R
D
V
Y
--
112
HHSearch
68.69
34%
-1
- C2 -
3QFS
2
NCPR_HUMAN
A:
[55-457]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--------------------------
P
-----------
F
D
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
Q
G
-
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
G
A
D
L
-----------
D
V
-------
V
--
M
S
L
N
N
LDEESNKKH--------
P
F
P
C
P
T
--------------------
S
--
Y
------
R
-----
T
A
L
T
Y
Y
L
D
I
T
------
N
P
P
R
T
N
V
-
L
Y
E
L
A
Q
Y
A
S
E
P
S
E
Q
E
L
L
R
K
---
M
A
S
SS
G
---
E
---
G
K
E
L
Y
L
S
W
V
VE
A
-----
R
-----
R
--
H
--
I
--
L
A
I
L
Q
D
C
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
V
V
E
---
Y
---
E
T
K--
A
--
G
R
I
---
N
K
G
V
A
T
-
N
W
L
R
A
K
E
P
V
G
E
NGG
R
A
L
-----
V
P
M
--
F
V
-
R
K
S
Q
-
F
R
L
P
F
-
K
A
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
---
A
-
W
L
R
Q
Q
G-
K
----
E
V
-----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
S
----
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
-
R
E
H
-
L
W
K
L
I
-
E
G
-
G
A
H
-
I
Y
V
C
G
D
A
-
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
36
PsiBlast_CBE
68.55
33%
-11
- C2 -
3QFS
2
NCPR_HUMAN
A:
[57-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
G
A
D
L
-----------
D
V
-------
V
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTS
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
---
L
A
Q
Y
A
S
E
P
S
E
Q
E
----
L
L
R
---
K
M
A
--
S
---
S
---
S
G
E
G
K
E
L
Y
L
--
S
WVVEA
R
-----
R
--
H
--
I
--
L
A
I
L
Q
D
C
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
R
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
V
V
E
---
Y
---
E
T
---
K
A-
G
R
I
---
N
K
G
V
A
T
-
N
W
L
R
A
K
E
P
V
G
E
-----
N
GG
R
A
L
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
A
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
Q
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
S
----
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
-
R
E
H
-
L
W
K
L
I
-
E
G
-
G
A
H
-
I
Y
V
C
G
D
A
-
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
37
PsiBlast_CBE
67.59
33%
-11
- C2 -
3QFT
2
NCPR_HUMAN
A:
[57-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
A
K
N
P
F
L
A
A
V
T
T
N
R
K
L
N
-
Q
G
T
E
R
H
L
M
H
L
E
L
D
I
S
D
-
S
K
-
I
R
Y
E
S
G
D
H
V
A
V
Y
P
A
N
D
S
A
L
V
N
Q
L
G
K
I
L
G
A
D
L
-----------
D
V
-------
V
--
M
S
L
N
N
LDE--------------
E
S
N
K
K
H
--------------------
P
--
F
PCPTS
Y
R
-----
T
A
L
T
Y
Y
L
D
I
T
NPPR
T
N
V
L
-
Y
E
---
L
A
Q
Y
A
S
E
P
S
E
Q
E
----
L
L
R
---
K
M
A
--
S
---
S
---
S
G
E
G
K
E
L
Y
L
--
S
W
VVEA
R
-----
R
--
H
--
I
--
L
A
I
L
Q
D
C
P
S
L
R
P
P
I
D
H
L
C
E
L
L
P
R
L
Q
A
H
Y
Y
S
I
A
S
S
S
---
K
V
H
---
P
N
S
V
H
I
C
A
V
------
V
V
E
---
Y
---
E
T
---
K
A-
G
R
I
---
N
K
G
V
A
T
-
N
W
L
R
A
K
E
P
V
-------
N
G
G
R
A
L
V
P
M
--
F
V
R
K
S
Q
--
F
R
L
P
F
-
K
A
T
T
P
V
I
M
V
G
P
G
T
G
V
A
P
F
I
G
-----
F
I
-----
Q
E
R
A
W
L
R
-
Q
Q
-----
G
----
K
E
V
----
G
----
E
----
T
L
L
Y
Y
G
C
R
R
S
D
E
D
Y
L
Y
R
E
E
L
A
Q
F
H
R
D
G
A
L
T
--
Q
L
N
V
A
F
S
R
----
E
Q
-
S
----
H
----
K
V
Y
V
Q
H
L
L
K
Q
D
-
R
E
H
-
L
W
K
L
I
-
E
G
-
G
A
H
-
I
Y
V
C
G
D
A
-
R
N
M
A
R
D
V
Q
N
T
F
Y
D
I
V
A
E
L
G
A
M
E
H
A
Q
A
V
D
Y
I
K
K
L
M
T
K
G
R
Y
S
L
D
V
W
--
115
HHSearch
63.25
35%
40
- C2 -
4DQL
5
CPXB_BACME
A:
[5-391]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
F
S
T
N
V
V
A
S
K
E
L
Q
Q
P
G
S
A
R
S
T
R
H
L
E
I
E
L
P
K
--
E
-
A
S
Y
Q
E
G
D
H
L
G
V
I
P
R
N
Y
E
G
I
V
N
R
V
T
A
R
F
G
L
D
A
-----------
S
Q
-------
Q
--
I
R
L
E
A--------------------
K
T
V
--------------------
S
--
V
------
E
-----
E
L
L
-
Q
Y
V
E
L
Q
------
D
P
V
T
R
T
Q
-
L
R
A
M
A
A
K
T
V
C
P
P
H
K
V
E
L
E
A
---
L
L
-----------
E
K
Q
A
Y
K
E
Q
V
LA
K
-----
R
-----
L
--
T
--
M
--
L
E
L
L
E
K
Y
P
A
C
E
M
K
F
S
E
F
I
A
L
L
P
S
I
R
P
R
Y
Y
S
I
S
S
S
P
---
R
V
D
---
E
K
Q
A
S
I
T
V
S
------
V
V
S
---
G
---
E
A
---
W
SG
Y
G
E
---
Y
K
G
I
A
S
-
N
Y
L
A
E
-
L
Q
E
G
D
-----
T
-----
I
T
C
F
I
S
T
-
P
Q
S
E
-
F
T
L
P
K
-
D
P
E
T
P
L
I
M
V
G
P
G
T
G
V
A
P
F
R
G
-----
F
V
-----
Q
A
R
---
K
-
Q
L
K
E
Q
G-
Q
----
S
L
-----
G
----
E
----
A
H
L
Y
F
G
C
R
S
P
H
E
D
Y
L
Y
Q
E
E
L
E
N
A
Q
S
E
G
I
I
T
---
L
H
T
A
F
S
R
----
M
P
-
N
Q---
P
----
K
T
Y
V
Q
H
V
M
E
Q
D
-
G
K
K
-
L
I
E
L
L
-
D
Q
-
G
A
H
-
F
Y
I
C
G
D
G
-
S
Q
M
A
P
A
V
E
A
T
L
M
K
S
Y
A
D
V
H
Q
V
S
E
A
D
A
R
L
W
L
Q
Q
L
E
E
K
G
R
Y
A
K
D
V
W
--
101
Fugue
62.55
30%
35
- C2 -
1F20
10
A:
[1-435]
----------------------------------------------------------------------------------------
S
W
-
K
R
N
K
F
R
L
T
Y
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
A
----
P
--
D
-----
L
---------------
T
---------------
Q
G
L
S
--------------------------
N
-----------
V
H
K
K
R
V
S
A
A
R
L
L
S
R
Q
N
L
Q
S
P
K
S
S
R
S
T
I
F
V
R
L
H
T
N
G
N
Q
E
-
L
Q
Y
Q
P
G
D
H
L
G
V
F
P
G
N
H
E
D
L
V
N
A
L
I
E
R
L
E
D
A
P
-----------
P
A
-------
N
--
H
V
V
K
------------------
V
E
M
L
E
E
RNTALG
V
I
S
N
W
K
D
ESRLPPC
T
--
I
------
F
-----
Q
A
F
K
Y
Y
L
D
I
T
T-----
P
P
-
T
P
L
Q
-
L
Q
Q
F
A
S
L
A
T
N
E
K
----
E
K
Q
---
R
L
L
--
V
L
S
-
K
---
G
L
Q
E
Y
E
E
W
K
--
W
-----
G
-----
K
NP
T
--
M
--
V
E
V
L
E
E
F
P
S
I
Q
M
P
A
T
L
L
L
T
Q
L
S
L
L
Q
P
R
Y
Y
S
I
S
S
S
P
---
D
M
Y
---
P
D
E
V
H
L
T
V
A
------
I
V
S
---
Y
H
T
R
D
G
---
E
--
G
P
V
---
H
H
G
V
C
S
-
S
W
L
-
N
R
I
Q
A
D
D
-----
V
-----
V
P
C
--
F
V
R
G
A
P
S
-
F
H
L
P
R
-
N
P
Q
V
P
C
I
L
V
G
P
G
T
G
I
A
P
F
R
S
-----
F
W
-----
Q
Q
R
---
Q
-
F
D
-----
I
----
Q
H
KGMNP
C
----
P
----
M
V
L
V
F
G
C
R
Q
S
K
I
D
H
I
Y
R
E
E
T
L
Q
A
K
N
K
G
V
F
R
--
E
L
Y
T
A
Y
S
R
----
E
P
D
R
----
P
----
K
K
Y
V
Q
D
V
L
Q
E
Q
L
A
E
S
-
V
Y
R
A
L
K
E
Q
-
G
G
H
-
I
Y
V
C
G
D
--
V
T
M
A
A
D
V
L
K
A
I
Q
R
I
M
T
Q
Q
G
K
L
S
E
E
D
A
G
V
F
I
S
R
L
R
D
D
N
R
Y
H
E
D
I
F
GV
116
HHSearch
62.40
31%
44
- C2 -
1F20
10
A:
[24-433]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
H
K
K
R
V
S
A
A
R
L
L
S
R
Q
N
L
Q
S
P
K
S
S
R
S
T
I
F
V
R
L
H
T
N
G
N
Q
E
-
L
Q
Y
Q
P
G
D
H
L
G
V
F
P
G
N
H
E
D
L
V
N
A
L
I
E
R
L
E
D
A
P
-----------
P
A
-------
N
H
V
V
K
V
E
M
LEERNTALG
V
I
S
N
W
K
D
E
S
R
L
P
P
C
--------------------
T
--
I
------
F
-----
Q
A
F
K
Y
Y
L
D
I
T
------
T
P
P
T
P
L
Q
-
L
Q
Q
F
A
S
L
A
T
N
E
K
E
K
Q
R
L
L
V
---
L
S
-------
K
---
G
L
Q
E
Y
E
E
W
K
W
G
K
-----
N
-----
P
--
T
--
M
--
V
E
V
L
E
E
F
P
S
I
Q
M
P
A
T
L
L
L
T
Q
L
S
L
L
Q
P
R
Y
Y
S
I
S
S
S
P
---
D
M
Y
---
P
D
E
V
H
L
T
V
A
------
I
V
S
---
Y
---
H
T
RDG
E
--
G
P
V
---
H
H
G
V
C
S
-
S
W
L
N
R
-
I
Q
A
D
D
-----
V
-----
V
P
C
--
F
V
R
G
A
P
S
-
F
H
L
P
R
-
N
P
Q
V
P
C
I
L
V
G
P
G
T
G
I
A
P
F
R
S
-----
F
W
-----
Q
Q
R
---
Q
-
F
D
I
QHKG
M
----
N
P
-----
C
----
P
----
M
V
L
V
F
G
C
R
Q
S
K
I
D
H
I
Y
R
E
E
T
L
Q
A
K
N
K
G
V
F
R
--
E
L
Y
T
A
Y
S
R
----
E
P
-
D
R---
P
----
K
K
Y
V
Q
D
V
L
Q
E
Q
L
A
E
S
-
V
Y
R
A
L
K
E
Q
-
G
G
H
-
I
Y
V
C
G
D
V
-
T
-
M
A
A
D
V
L
K
A
I
Q
R
I
M
T
Q
Q
G
K
L
S
E
E
D
A
G
V
F
I
S
R
L
R
D
D
N
R
Y
H
E
D
I
F
--
41
PsiBlast_CBE
62.19
31%
46
- C2 -
1F20
10
A:
[33-433]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
L
S
R
Q
N
L
Q
S
P
K
S
S
R
S
T
I
F
V
R
L
H
T
N
G
-
N
Q
E
L
Q
Y
Q
P
G
D
H
L
G
V
F
P
G
N
H
E
D
L
V
N
A
L
I
E
R
L
E
D
A
P
PAN
H
V
V
K
V
E
M
L
E
E
RNTALG
V
I
--
S
N
W
K
------------------
D
E
S
R
L
P
--------------------
P
CT
I
------
F
-----
Q
A
F
K
Y
Y
L
D
I
T
------
T
P
-
P
T
P
L
Q
L
Q
Q
F
A
S
L
A
T
N
E
K
----
E
K
Q
R
L
L
V
L
S
--
K
---
G
---
L
Q
E
-
Y
E
E
W
K
--
W
-----
G
-----
K
--
N
PT
M
--
V
E
V
L
E
E
F
P
S
I
Q
M
P
A
T
L
L
L
T
Q
L
S
L
L
Q
P
R
Y
Y
S
I
S
S
S
P
---
D
M
Y
---
P
D
E
V
H
L
T
V
A
------
I
V
S
---
Y
H
T
R
D
G
---
E
--
G
P
V
---
H
H
G
V
C
S
-
S
W
L
-
N
R
I
Q
A
D
D
-----
V
-----
V
P
C
--
F
V
R
G
A
P
S
-
F
H
L
P
R
-
N
P
Q
V
P
C
I
L
V
G
P
G
T
G
I
A
P
F
R
S
-----
F
W
-----
Q
Q
R
---
Q
F
D
I
-----
Q
----
H
K
-----
G
MNPC
P
----
M
V
L
V
F
G
C
R
Q
S
K
I
D
H
I
Y
R
E
E
T
L
Q
A
K
N
K
G
V
F
R
--
E
L
Y
T
A
Y
S
R
----
E
P
-
D
----
R
P---
K
K
Y
V
Q
D
V
L
Q
E
Q
-
L
A
E
S
V
Y
R
A
L
-
K
E
Q
G
G
H
-
I
Y
V
C
G
D
V
-
T
-
M
A
A
D
V
L
K
A
I
Q
R
I
M
T
Q
Q
G
K
L
S
E
E
D
A
G
V
F
I
S
R
L
R
D
D
N
R
Y
H
E
D
I
F
--
40
PsiBlast_CBE
61.16
33%
44
- C2 -
4DQL
5
CPXB_BACME
A:
[7-391]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
T
N
V
V
A
S
K
E
L
Q
Q
P
G
S
A
R
S
T
R
H
L
E
I
E
L
P
K
-
E
A
--
S
Y
Q
E
G
D
H
L
G
V
I
P
R
N
Y
E
G
I
V
N
R
V
T
A
R
F
G
L
D
A
-----------
S
Q
-------
Q
--
I
R
L
E
------------------
A
------------------------------------
K
T
V
S
V
E
E
L
L
Q
Y
V
E
L
Q
DP----
V
T
-
R
T
Q
L
-
R
A
M
A
A
K
T
V
C
P
P
H
----
K
V
E
---
L
E
A
--
L
---
L
---
E
K
Q
A
Y
K
E
Q
V
--
L
-----
A
-----
K
--
R
--
L
T
M
L
E
L
L
E
K
Y
P
A
C
E
M
K
F
S
E
F
I
A
L
L
P
S
I
R
P
R
Y
Y
S
I
S
S
S
P
---
R
V
D
---
E
K
Q
A
S
I
T
V
S
------
V
V
S
GEA
W
---
S
G
---
Y
--
G
-
E
---
Y
K
G
I
A
S
-
N
Y
L
A
E
-
L
Q
E
G
D
-----
T
-----
I
T
C
--
F
I
S
T
P
Q
S
E
F
T
L
P
K
-
D
P
E
T
P
L
I
M
V
G
P
G
T
G
V
A
P
F
R
G
-----
F
V
-----
Q
A
R
---
K
-
Q
L
-----
K
----
E
Q
-----
G
----
Q
S
L
G
E
A
H
L
Y
F
G
C
R
S
P
H
E
D
Y
L
Y
Q
E
E
L
E
N
A
Q
S
E
G
I
I
T
---
L
H
T
A
F
S
R
M---
P
N
-
Q
----
P
----
K
T
Y
V
Q
H
V
M
E
Q
D
-
G
K
K
-
L
I
E
L
L
-
D
Q
-
G
A
H
-
F
Y
I
C
G
D
G
-
S
Q
M
A
P
A
V
E
A
T
L
M
K
S
Y
A
D
V
H
Q
V
S
E
A
D
A
R
L
W
L
Q
Q
L
E
E
K
G
R
Y
A
K
D
V
W
--
39
PsiBlast_CBE
59.65
33%
43
- C2 -
4DQL
5
B:
[7-391]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
T
N
V
V
A
S
K
E
L
Q
Q
P
G
S
A
R
S
T
R
H
L
E
I
E
L
P
K
-
E
A
--
S
Y
Q
E
G
D
H
L
G
V
I
P
R
N
Y
E
G
I
V
N
R
V
T
A
R
F
G
L
D
A
-----------
S
Q
-------
Q
--
I
R
L
--------------------------------------------------------KTVS
V
E
E
L
L
Q
Y
V
E
L
Q
DP----
V
T
-
R
T
Q
L
-
R
A
M
A
A
K
T
V
C
P
P
H
----
K
V
E
---
L
E
A
--
L
---
L
---
E
K
Q
A
Y
K
E
Q
V
--
L
-----
A
-----
K
--
R
--
L
T
M
L
E
L
L
E
K
Y
P
A
C
E
M
K
F
S
E
F
I
A
L
L
P
S
I
R
P
R
Y
Y
S
I
S
S
S
P
---
R
V
D
---
E
K
Q
A
S
I
T
V
S
------
V
V
S
G
EA
W
---
S
G
---
Y
--
G
-
E
---
Y
K
G
I
A
S
-
N
Y
L
A
E
-
L
Q
E
G
D
-----
T
-----
I
T
C
--
F
I
S
T
P
Q
S
E
F
T
L
P
K
-
D
P
E
T
P
L
I
M
V
G
P
G
T
G
V
A
P
F
R
G
-----
F
V
-----
Q
A
R
---
K
-
Q
L
-----
K
----
E
Q
-----
G
----
Q
S
L
G
E
A
H
L
Y
F
G
C
R
S
P
H
E
D
Y
L
Y
Q
E
E
L
E
N
A
Q
S
E
G
I
I
T
---
L
H
T
A
F
S
R
M---
P
N
-
Q
----
P
----
K
T
Y
V
Q
H
V
M
E
Q
D
-
G
K
K
-
L
I
E
L
L
-
D
Q
-
G
A
H
-
F
Y
I
C
G
D
G
-
S
Q
M
A
P
A
V
E
A
T
L
M
K
S
Y
A
D
V
H
Q
V
S
E
A
D
A
R
L
W
L
Q
Q
L
E
E
K
G
R
Y
A
K
D
V
W
--
42
PsiBlast_CBE
46.76
45%
-111
- C2 -
1YKG
1
CYSJ_ECOLI
A:
[12-154]
-------------------------------------------------------------------
I
T
I
I
S
A
S
Q
T
G
N
A
R
R
V
A
E
A
L
R
D
D
L
-
L
A
A
K
L
N
V
K
L
V
N
A
G
D
Y
K
F
---
K
Q
---
I
A
--
S
E
----
K
L
-----
L
-----
I
-
V
V
--
T
S
T
Q
G
E
G
E
P
P
E
E
A
V
A
L
H
K
F
L
F
S
K
K
---------------
A
P
K
L
E
N
T
A
F
A
V
F
S
L
G
D
T
S
Y
E
F
F
C
Q
S
G
K
D
F
D
S
K
L
A
E
L
G
G
E
R
L
L
D
--
R
V
--
D
A
D
---
V
E
--
Y
--
Q
A
A
A
S
E
W
R
A
R
V
V
D
A
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
41.44
34%
23
- C2 -
4AF6
1
FENR1_PEA
A:
[87-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T
--
N
D
---
A
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
V
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
58
PsiBlast_CBE
41.36
33%
24
- C2 -
3LVB
1
?
A:
[85-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
L
Y
S
I
A
S
T
R
---
Y
G
-----
D
N
F
D
G
R
T
G
S
L
C
V
R
R
A
V
Y
---
Y
---
D
P
---
E
T-
G
K
E
DPS
K
N
G
V
C
S
N
F
L
C
N
S
K
--
P
G
D
-----
K
-----
I
Q
L
--
T
G
P
S
G
K
I
-
M
L
L
P
E
E
D
P
N
A
T
H
I
M
I
A
T
G
T
G
V
A
P
F
R
G
Y
L
R
R
M
F
M
-----
E
D
V
---
P
-
N
Y
-----
R
----
F
G
-----
G
----
L
----
A
W
L
F
L
G
V
A
N
-
S
D
S
L
L
Y
D
E
E
F
T
S
Y
L
K
Q
Y
P
D
N
F
-
R
Y
D
K
A
L
S
R
----
E
Q
-
K
----
N
R
S
G
G
K
M
Y
V
Q
D
K
I
E
E
Y
-
S
D
E
-
I
F
K
L
L
-
D
G
-
G
A
H
-
I
Y
F
C
G
-
L
-
K
G
M
M
P
G
I
Q
D
T
L
K
K
V
A
E
R
R
G
----
E
S
W
D
Q
K
L
A
Q
L
K
K
N
K
Q
W
H
V
E
V
Y
--
74
PsiBlast_CBE
41.30
33%
20
- C2 -
1FND
3
FENR_SPIOL
A:
[93-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
LGD
F
G
D
---
A
K
S
V
S
L
C
V
K
------
R
L
I
---
Y
T
--
N
D
---
A
--
G
E
T
---
I
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
A
-----
E
-----
V
K
L
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
D
N
F
-
R
L
D
F
A
V
S
R
----
E
Q
-
T
NEKG
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
V
E
-
L
W
E
M
L
K
K
D
-
N
T
Y
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
A
E
G
---------------------------
57
PsiBlast_CBE
40.78
33%
21
- C2 -
1JB9
1
?
A:
[90-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
L
Y
S
I
A
S
T
R
---
Y
G
-----
D
N
F
D
G
R
T
G
S
L
C
V
R
R
A
V
Y
---
Y
---
D
P
---
E
T-
G
K
E
DPS
K
N
G
V
C
S
N
F
L
C
N
S
K
--
P
G
D
-----
K
-----
I
Q
L
--
T
G
P
S
G
K
I
-
M
L
L
P
E
E
D
P
N
A
T
H
I
M
I
A
T
G
T
G
V
A
P
F
R
G
Y
L
R
R
M
F
M
-----
E
D
V
---
P
-
N
Y
-----
R
----
F
G
-----
G
----
L
----
A
W
L
F
L
G
V
A
N
-
S
D
S
L
L
Y
D
E
E
F
T
S
Y
L
K
Q
Y
P
D
N
F
-
R
Y
D
K
A
L
S
R
----
E
Q
-
K
-----G---
K
M
Y
V
Q
D
K
I
E
E
Y
-
S
D
E
-
I
F
K
L
L
-
D
G
-
G
A
H
-
I
Y
F
C
G
-
L
-
K
G
M
M
P
G
I
Q
D
T
L
K
K
V
A
E
R
R
G
----
E
S
W
D
Q
K
L
A
Q
L
K
K
N
K
Q
W
H
V
E
V
Y
--
75
PsiBlast_CBE
40.52
33%
20
- C2 -
1FNC
3
FENR_SPIOL
A:
[93-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
LGD
F
G
D
---
A
K
S
V
S
L
C
V
K
------
R
L
I
---
Y
T
--
N
D
---
A
--
G
E
T
---
I
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
A
-----
E
-----
V
K
L
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
D
N
F
-
R
L
D
F
A
V
S
R
----
E
Q
-
T
NEKG
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
V
E
-
L
W
E
M
L
K
K
D
-
N
T
Y
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
A
E
G
---------------------------
84
PsiBlast_CBE
40.46
32%
11
- C2 -
1FRN
3
FENR_SPIOL
A:
[93-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
V
I
A
S
S
A
LGD
F
G
D
---
A
K
S
V
S
L
C
V
K
------
R
L
I
---
Y
T
--
N
D
---
A
--
G
E
T
---
I
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
A
-----
E
-----
V
K
L
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
D
N
F
-
R
L
D
F
A
V
S
R
----
E
Q
-
T
NEKG
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
V
E
-
L
W
E
M
L
K
K
D
-
N
T
Y
-
F
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
A
E
G
---------------------------
64
PsiBlast_CBE
40.26
34%
25
- C2 -
4AF6
1
FENR1_PEA
B:
[87-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T--
N
D
---
A
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
WKMFF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
V
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
63
PsiBlast_CBE
40.12
34%
26
- C2 -
1QFY
3
FENR1_PEA
A:
[87-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T
--
N
D
---
A
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
71
PsiBlast_CBE
40.09
34%
26
- C2 -
1QGA
3
FENR1_PEA
A:
[87-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T
--
N
D
---
A
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
67
PsiBlast_CBE
40.01
34%
23
- C2 -
3MHP
1
FENR1_PEA
A:
[74-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T
--
N
D
---
A
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
43
PsiBlast_CBE
40.00
35%
32
- C2 -
3VO1
1
?
B:
[93-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
LGD
F
G
D
---
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T--
N
D
---
Q
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
A
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
A
T
G
T
G
I
A
P
F
R
S
-----
F
L
WKMFF
E
E
H
---
E
-
D
Y
-----
K
----
Y
T
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
S
D
T
-
L
L
Y
K
E
E
L
E
K
-
M
K
E
M
A
P
D
NF
R
L
D
F
A
V
S
R
----
E
Q
-
T
NAAG
E
----
K
M
Y
I
Q
T
R
M
A
E
Y
-
K
E
E
-
L
W
E
L
L
K
K
D
-
N
T
Y
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
L
D
L
A
A
K
D
G
---------------------------
50
PsiBlast_CBE
39.97
34%
30
- C2 -
3W5V
1
?
A:
[92-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
I
---
Y
T
--
N
D
---
A
--
G
E
I
---
V
K
G
V
C
S
N
F
L
C
--
D
L
Q
P
G
D
-----
N
-----
V
Q
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
A
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
G
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
G
K
-
M
K
E
R
A
P
E
N
F
R
V
D
Y
A
V
S
R
----
E
Q
-
T
NAAG
E
----
R
M
Y
I
Q
T
R
M
A
E
Y
-
K
E
E
-
L
W
E
L
L
K
K
D
-
N
T
Y
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
E
K
D
G
---------------------------
44
PsiBlast_CBE
39.96
35%
30
- C2 -
3VO1
1
?
A:
[93-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
LGD
F
G
D
---
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T
--
N
D
---
Q
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
A
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
A
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
E
H
---
E
-
D
Y
-----
K
----
Y
T
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
S
D
T
-
L
L
Y
K
E
E
L
E
K
-
M
K
E
M
A
P
D
N
F
R
L
D
F
A
V
S
R
----
E
Q
-
T
NAAG
E
----
K
M
Y
I
Q
T
R
M
A
E
Y
-
K
E
E
-
L
W
E
L
L
K
K
D
-
N
T
Y
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
L
D
L
A
A
K
D
G
---------------------------
79
PsiBlast_CBE
39.92
33%
24
- C2 -
4AF7
1
FENR1_PEA
B:
[87-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T
--
N
D
---
A
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
M
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
76
PsiBlast_CBE
39.86
33%
20
- C2 -
1FNB
3
FENR_SPIOL
A:
[93-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
LGD
F
G
D
---
A
K
S
V
S
L
C
V
K
------
R
L
I
---
Y
T
--
N
D
---
A
--
G
E
T
---
I
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
A
-----
E
-----
V
K
L
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
D
N
F
-
R
L
D
F
A
V
S
R
----
E
Q
-
T
NEKG
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
V
E
-
L
W
E
M
L
K
K
D
-
N
T
Y
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
A
E
G
---------------------------
61
PsiBlast_CBE
39.76
34%
28
- C2 -
1QFZ
3
FENR1_PEA
A:
[87-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T
--
N
D
---
A
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
83
PsiBlast_CBE
39.72
33%
22
- C2 -
1BX1
3
FENR_SPIOL
A:
[93-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
LGD
F
G
D
---
A
K
S
V
S
L
C
V
K
------
R
L
I
---
Y
T
--
N
D
---
A
--
G
E
T
---
I
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
A
-----
E
-----
V
K
L
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
D
N
F
-
R
L
D
F
A
V
S
R
----
E
Q
-
T
NEKG
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
V
E
-
L
W
E
M
L
K
K
D
-
N
T
Y
-
F
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
A
E
G
---------------------------
68
PsiBlast_CBE
39.56
34%
24
- C2 -
1QG0
1
FENR1_PEA
B:
[87-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T--
N
D
---
A
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
WKMFF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
46
PsiBlast_CBE
39.43
34%
33
- C2 -
1GAW
1
?
A:
[92-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
I
---
Y
T
--
N
D
---
A
--
G
E
I
---
V
K
G
V
C
S
N
F
L
C
--
D
L
Q
P
G
D
-----
N
-----
V
Q
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
A
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
G
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
G
K
-
M
K
E
R
A
P
E
N
F
R
V
D
Y
A
V
S
R
----
E
Q
-
T
NAAG
E
----
R
M
Y
I
Q
T
R
M
A
E
Y
-
K
E
E
-
L
W
E
L
L
K
K
D
-
N
T
Y
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
E
K
D
G
---------------------------
66
PsiBlast_CBE
39.37
34%
26
- C2 -
3MHP
1
FENR1_PEA
B:
[74-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
-----------------
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
47
PsiBlast_CBE
39.29
34%
26
- C2 -
1GAQ
1
?
C:
[92-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
I
---
Y
T--
N
D
---
A
--
G
E
I
---
V
K
G
V
C
S
N
F
L
C
--
D
L
Q
P
G
D
-----
N
-----
V
Q
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
A
T
G
T
G
I
A
P
F
R
S
-----
F
L
WKMFF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
G
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
G
K
-
M
K
E
R
A
P
E
NF
R
V
D
Y
A
V
S
R
----
E
Q
-
T
NAAG
E
----
R
M
Y
I
Q
T
R
M
A
E
Y
-
K
E
E
-
L
W
E
L
L
K
K
D
-
N
T
Y
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
E
K
D
G
---------------------------
77
PsiBlast_CBE
39.27
33%
39
- C2 -
2XNC
2
FENR1_PEA
B:
[102-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
---
F
G
D
S
K
T
V
S
L
------
C
V
K
----------------
R
V
---
P
D
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
81
PsiBlast_CBE
39.22
33%
19
- C2 -
1FRQ
3
FENR_SPIOL
A:
[93-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
LGD
F
G
D
---
A
K
S
V
S
L
C
V
K
------
R
L
I
---
Y
T
--
N
D
---
A
--
G
E
T
---
I
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
A
-----
E
-----
V
K
L
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
D
N
F
-
R
L
D
F
A
V
S
R
----
E
Q
-
T
NEKG
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
V
E
-
L
W
E
M
L
K
K
D
-
N
T
Y
-
F
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
A
E
G
---------------------------
72
PsiBlast_CBE
39.18
33%
24
- C2 -
1SM4
2
?
B:
[75-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
LGD
F
G
D
---
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T--
N
D
---
K
--
G
E
E
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
A
-----
D
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
WKMFF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F-
R
L
D
F
A
V
S
R
----
E
Q
-
T
NEKG
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
T
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
Q
G
I
D
D
I
M
S
S
L
A
A
K
E
G
---------------------------
69
PsiBlast_CBE
39.12
34%
24
- C2 -
1QG0
1
FENR1_PEA
A:
[87-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T
--
N
D
---
A
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
59
PsiBlast_CBE
38.99
33%
22
- C2 -
3LO8
2
?
A:
[85-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
L
Y
S
I
A
S
T
R
---
Y
G
-----
D
N
F
D
G
R
T
G
S
L
C
V
R
R
A
V
Y
---
Y
---
D
P
---
E
T-
G
K
E
DPS
K
N
G
V
C
S
N
F
L
C
N
S
K
--
P
G
D
-----
K
-----
I
Q
L
--
T
G
P
S
G
K
I
-
M
L
L
P
E
E
D
P
N
A
T
H
I
M
I
A
T
G
T
G
V
A
P
F
R
G
Y
L
R
R
M
F
M
-----
E
D
V
---
P
-
N
Y
-----
R
----
F
G
-----
G
----
L
----
A
W
L
F
L
G
V
A
N
-
S
D
S
L
L
Y
D
E
E
F
T
S
Y
L
K
Q
Y
P
D
N
F
-
R
Y
D
K
A
L
S
R
----
E
Q
------------
M
Y
V
Q
D
K
I
E
E
Y
-
S
D
E
-
I
F
K
L
L
-
D
G
-
G
A
H
-
I
Y
F
C
G
-
L
-
K
G
M
M
P
G
I
Q
D
T
L
K
K
V
A
E
R
R
G
----
E
S
W
D
Q
K
L
A
Q
L
K
K
N
K
Q
W
H
V
E
V
Y
--
49
PsiBlast_CBE
38.80
34%
27
- C2 -
3W5V
1
?
C:
[92-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
I
---
Y
T--
N
D
---
A
--
G
E
I
---
V
K
G
V
C
S
N
F
L
C
--
D
L
Q
P
G
D
-----
N
-----
V
Q
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
A
T
G
T
G
I
A
P
F
R
S
-----
F
L
WKMFF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
G
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
G
K
-
M
K
E
R
A
P
E
NF
R
V
D
Y
A
V
S
R
----
E
Q
-
T
NAAG
E
----
R
M
Y
I
Q
T
R
M
A
E
Y
-
K
E
E
-
L
W
E
L
L
K
K
D
-
N
T
Y
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
E
K
D
G
---------------------------
82
PsiBlast_CBE
38.73
33%
22
- C2 -
1BX0
3
FENR_SPIOL
A:
[93-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
LGD
F
G
D
---
A
K
S
V
S
L
C
V
K
------
R
L
I
---
Y
T
--
N
D
---
A
--
G
E
T
---
I
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
A
-----
E
-----
V
K
L
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
D
N
F
-
R
L
D
F
A
V
S
R
----
E
Q
-
T
NEKG
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
V
E
-
L
W
E
M
L
K
K
D
-
N
T
Y
-
F
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
A
E
G
---------------------------
80
PsiBlast_CBE
38.50
33%
27
- C2 -
4AF7
1
FENR1_PEA
A:
[87-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T
--
N
D
---
A
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
M
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
56
PsiBlast_CBE
38.45
34%
23
- C2 -
3VO2
1
?
A:
[89-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
LGD
F
G
D
---
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T
--
N
D
---
Q
--
G
E
I
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
A
-----
D
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
A
T
G
T
G
I
A
P
F
R
S
F
L
W
K
M
F
L
-----
E
E
H
---
E
-
D
Y
-----
K
----
F
S
-----
G
----
L
----
A
W
L
F
L
G
-
V
P
T
S
D
S
L
L
Y
K
E
E
L
E
K
-
M
K
E
M
A
P
D
N
F
R
L
D
F
A
V
S
R
----
E
Q
-
T
NAAG
E
----
K
M
Y
I
Q
T
R
M
A
E
Y
-
R
E
E
-
L
W
E
L
L
K
K
D
-
N
T
Y
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
L
N
L
A
A
K
D
G
---------------------------
73
PsiBlast_CBE
38.43
33%
22
- C2 -
1SM4
2
?
A:
[75-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
LGD
F
G
D
---
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T--
N
D
---
K
--
G
E
E
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
A
-----
D
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
----
E
Q
-
T
NEKG
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
T
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
Q
G
I
D
D
I
M
S
S
L
A
A
K
E
G
---------------------------
60
PsiBlast_CBE
38.28
34%
30
- C2 -
1QFZ
2
FENR1_PEA
B:
[87-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T
--
N
D
---
A
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
48
PsiBlast_CBE
38.24
34%
30
- C2 -
1GAQ
1
?
A:
[92-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
I
---
Y
T
--
N
D
---
A
--
G
E
I
---
V
K
G
V
C
S
N
F
L
C
--
D
L
Q
P
G
D
-----
N
-----
V
Q
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
A
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
G
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
G
K
-
M
K
E
R
A
P
E
N
F
R
V
D
Y
A
V
S
R
----
E
Q
-
T
NAAG
E
----
R
M
Y
I
Q
T
R
M
A
E
Y
-
K
E
E
-
L
W
E
L
L
K
K
D
-
N
T
Y
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
E
K
D
G
---------------------------
55
PsiBlast_CBE
38.20
34%
25
- C2 -
3VO2
1
?
B:
[89-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
LGD
F
G
D
---
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T--
N
D
---
Q
--
G
E
I
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
A
-----
D
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
A
T
G
T
G
I
A
P
F
R
S
FLWKM
F
L
-----
E
E
H
---
E
-
D
Y
-----
K
----
F
S
-----
G
----
L
----
A
W
L
F
L
G
-
V
P
T
S
D
S
L
L
Y
K
E
E
L
E
K
-
M
K
E
M
A
P
D
NF
R
L
D
F
A
V
S
R
----
E
Q
-
T
NAAG
E
----
K
M
Y
I
Q
T
R
M
A
E
Y
-
R
E
E
-
L
W
E
L
L
K
K
D
-
N
T
Y
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
L
N
L
A
A
K
D
G
---------------------------
45
PsiBlast_CBE
38.07
34%
33
- C2 -
1GAW
1
?
B:
[92-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
I
---
Y
T
--
N
D
---
A
--
G
E
I
---
V
K
G
V
C
S
N
F
L
C
--
D
L
Q
P
G
D
-----
N
-----
V
Q
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
I
I
M
L
A
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
D
-
D
Y
-----
K
----
F
N
-----
G
----
L
----
G
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
G
K
-
M
K
E
R
A
P
E
N
F
R
V
D
Y
A
V
S
R
----
E
Q
-
T
NAAG
E
----
R
M
Y
I
Q
T
R
M
A
E
Y
-
K
E
E
-
L
W
E
L
L
K
K
D
-
N
T
Y
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
E
K
D
G
---------------------------
70
PsiBlast_CBE
37.83
34%
27
- C2 -
1QGA
2
FENR1_PEA
B:
[87-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T
--
N
D
---
A
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
62
PsiBlast_CBE
37.82
34%
30
- C2 -
1QFY
2
FENR1_PEA
B:
[87-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
FGD
S
K
T
V
S
L
C
V
K
------
R
L
V
---
Y
T
--
N
D
---
A
--
G
E
V
---
V
K
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------
78
PsiBlast_CBE
37.67
33%
40
- C2 -
2XNC
4
FENR1_PEA
A:
[102-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
Y
S
I
A
S
S
A
---
I
G
D
---
F
G
D
S
K
T
V
S
L
------
C
V
K
----------------
R
V
---
P
D
G
V
C
S
N
F
L
C
--
D
L
K
P
G
S
-----
E
-----
V
K
I
--
T
G
P
V
G
K
E
-
M
L
M
P
K
-
D
P
N
A
T
V
I
M
L
G
T
G
T
G
I
A
P
F
R
S
-----
F
L
W
K
M
FF
E
K
H
---
E
-
D
Y
-----
Q
----
F
N
-----
G
----
L
----
A
W
L
F
L
G
V
P
T
-
S
S
S
L
L
Y
K
E
E
F
E
K
M
K
E
K
A
P
E
N
F
-
R
L
D
F
A
V
S
R
EQVN
D
K
-
G
----
E
----
K
M
Y
I
Q
T
R
M
A
Q
Y
-
A
E
E
-
L
W
E
L
L
K
K
D
-
N
T
F
-
V
Y
M
C
G
-
L
-
K
G
M
E
K
G
I
D
D
I
M
V
S
L
A
A
K
D
G
---------------------------