@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu38040: (2016-08-03 )
MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDPNGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCYSGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHFRDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYMWECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELDQGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKLIQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTATFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSARYFPFPGNHEVTASATGKSEMNVGIWTLM
Atome Classification :
(25 SA)
.........10........20........30-----........40........50........60.......-.70........80........90....-..-..100......-.---------110--------.--..-......----120.---..--------...-.130...----....-----140..---...---..---..150.----.--.----------.---....-160..-..-..--.--170.......180.......190......-.200........210.......220...-----...------------------.---------------230----....--....240.......250..-.....260.......270-------.---------........280-.........---290-.........300----........310-.......320.......--330-.-.---.......340.....---..350--.-......360...--....370.-----...---..----------------------------.----------------------------380-------------.........390------........400---.---------.-------......410-----.-----..-----.--..--.420----.....------..430.......440.......450.....-.---.---460....-.----.---.470.......----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTA
H
D
Q
E
L
R
R
R
A
Y
E
E
V
E
KKEPIANSDPHR
Q
H
-----
F
HIMPPVGLLNDPN
G
V
I
Y
WKG
S
Y
H
V
F
F
Q
W
QPFQTGHG-A
K
F
W
G
HY
T
T
Q
D
V
VNW
K
R
E
E
I
ALAPSDW-FD-KNGCYSGSAVT-K---------D----------D--
R
L
-
Y
L
F
Y
TG----NVRD---QD--------GNR-
E
T
Y
Q
C
L
A
----VSDD-----G--LS---
F
E
K---KG---
V
V
A
R-L----P--E----------G---YTAH-FRDPK-VW-EH--E--G
T
W
Y
M
V
IGAQTENLKG
Q
A
V
L
F
ASDNLT
E
W
-
R
F
L-GPITGAGFNGLDDFGYMWECP
D
L
F-----SLQ------------------G---------------S
D
-----
V
L
I
V--SPQGLEADG
F
R
Y
Q
N
V
YQS
G
-
Y
F
V
G
RLDYNKPELKHG---------E---------FTELDQGFD---FYAPQTLED---D---QG
R
R
I
L
F
A
W
MA-----VPDQDEGSH
P
T
-
I
D
C
H
W
I
H
C
MTL
P
R
QLTL--
S
---
G
-
Q
---
K
L
I
QQP
L
P
E
L
K
A
M
RR---NE
K
K
I
--
H
-
I
N
M
HGSSGALPV--EKP
E
R
T
E
I
-----
L
L
E
---DI----------------------------H----------------------------T---------------ES
G
F
S
I
S
I
R
G
-
T
------
A
T
F
S
FHKDE
G
----
I
---------
V
-------
T
L
E
RKSFDG-----K-----RT-----E--A
R
--
H
C
R
I
----
K
D
L
H
T
------
V
H
M
F
LDA
S
S
V
E
I
F
I
NN
G
E
E
V
L
SARYFPFPG-N---H---
E
V
T
ASAT-G----K---SE
M
N
V
G
I
W
T
LM----
32
HHSearch
89.85
30%
-7
* C2 *
3PIJ
3
?
A:
[33-513]
---------------------
A
K
R
N
N
R
W
Y
P
K
-----
Y
H
I
A
S
N
G
G
W
I
N
D
P
N
G
L
C
F
Y
K
G
R
W
H
V
F
Y
Q
L
H
P
Y
G
T
Q
W
G
P
M
-
H
W
G
H
V
S
S
T
D
M
L
N
W
K
R
E
P
I
M
F
A
P
S
L
E
-
Q
E
-
K
D
G
V
F
S
G
S
A
V
I
-
D
D--------
N
----------
G
--
D
L
-
R
F
Y
Y
T
G
----
H
R
W
A
---
N
G
HDNT----
G
G
D
-
W
Q
V
Q
M
T
A
----
L
P
D
N
DE---
L
--
T
S
---
A
T
K
---
Q
G
M--
I
I
D
C
-
P
----
T
--
D
----------
K
---
V
D
H
H
-
Y
R
D
P
K
-
V
W
-
K
T
--
G
--
D
T
W
Y
M
T
F
G
V
S
S
A
D
K
R
G
Q
M
W
L
F
S
S
K
D
M
V
R
W
-
E
Y
E
-
R
V
L
F
Q
H
----
P
D
P
D
V
F
M
L
E
C
P
D
F
S
-----
P
I
K
D
KDG
N
-------------
E
---------------
K
W
-----
V
I
G
F
--
S
A
M
G
S
K
P
S
G
F
M
N
R
N
V
S
N
A
G
-
Y
M
I
G
T
W
E
P
G
-
G
E
F
K
P
E
T--------
E
---------
F
R
L
W
D
C
G
H
N
---
Y
Y
A
P
Q
S
F
N
V
-------
D
G
R
Q
I
V
Y
G
W
M
S
-----
P
F
V
Q
P
---
I
P
M
-
E
D
D
G
W
C
G
Q
L
T
L
P
R
E
I
T
L
--
G
D--
D
-
G
---
D
V
V
T
A
P
V
A
E
M
E
G
L
R
E
---
D
T
L
D
H
G
-
S
-
V
T
L
D
M
-
D
G
E
Q
I
I
A-
D
D
A
E
A
V
E
I
-----
E
M
T
I
--
D
L
----------------------------
A
AS--------------------------
T
---------------
A
E
R
A
G
L
K
I
H
A
-
T
EDG
A
Y
-
T
Y
V
A
Y
D
G
Q
I
G
----
R
---------
V
-------
V
V
D
R
Q
A
M
A
N
G
----
D
R
G
---
Y
R
A
A
---
P
--
L
T
--
D
A
E
L
A
---
S
G
K
L
D
------
L
R
V
F
V
D
R
G
S
V
E
V
Y
V
N
G
G
H
Q
V
L
S
S
Y
S
Y
A
S
E
G
-
P
---
R
---
A
I
K
L
V
A
E
-
S
----
G
S
L
-
K
V
D
S
L
K
L
H
H
M
K
----
36
HHSearch
79.97
24%
-28
- C2 -
3UGF
11
?
A:
[7-537]
----------------
P
Y
P
W
S
N
A
Q
L
S
W
Q
R
T
A
-----
F
H
F
Q
P
E
R
S
W
M
S
D
P
D
G
P
I
F
Y
K
G
W
Y
H
F
F
Y
Q
Y
N
P
D
N
P
V
W
G
N
N
-
T
W
G
H
T
V
S
R
D
L
I
H
W
L
Y
L
P
L
A
L
A
A
D
Q
W
-
Y
D
-
M
Q
G
V
F
S
G
S
A
T
C
L
P
---------
D
----------
G
--
R
I
-
M
M
L
Y
T
G
----
V
T
K
E
---------------
M
-
V
E
M
L
S
L
A
----
Y
P
A
D
LSDPL
L
--
V
E
---
W
V
K
---
Y
P
GN-
P
I
L
S
-
A
P
---
P
--
G
----------
V
---
S
P
T
E
-
F
R
D
A
S
-
T
G
-
W
Y
V
S
N
--
G
T
W
R
I
A
I
G
A
K
Y
N
-
T
T
G
I
A
M
V
Y
E
T
K
D
F
K
S
F
-
K
L
L
-
E
E
L
L
H
A
-----
V
P
D
T
G
L
W
E
C
V
D
L
Y
-----
P
V
S
------------------
T
TGE
K
G
L
E
TSVNGPK
V
K
H
-----
V
L
K
A
--
S
I
D
E
Q
----------
Q
R
D
Y
-
Y
A
I
G
T
Y
D
L
G
T
N
K
W
T
P
D
NPEEDVG--
I
---------
G
L
R
Y
D
W
G
-
K
---
Y
Y
A
S
K
T
F
Y
D
---
P
K--
K
Q
R
R
V
V
W
A
W
T
K
-----
E
L
D
S
E
---
V
A
D
-
R
E
K
G
W
A
N
V
Q
T
I
P
R
T
V
L
L
--
D
Q--
K
T
G
T--
N
V
L
L
W
P
V
E
E
V
E
S
L
R
L
---
S
S
K
E
F
S
-
K
-
V
K
A
G
A
-
G
S
V
V
P
L
D
V
G
T
A
T
Q
L
D
I
-----
I
A
E
F
--
E
I
----------------------------
D
----------------------------
K
GYNCTTSGGAAERGV
L
G
P
F
G
L
L
V
S
A
-
T
ENLS
E
Q
T
P
V
Y
F
Y
I
A
K
-N
F
K
T
F
---------
F
-------
C
L
D
E
S
R
S
S
K
AS---
D
-----
V
S
K----
Q
--
V
K
G
F
T
V
P
V
L
D--
G
E
K
F
T
------
M
R
L
L
V
D
H
S
I
V
E
S
F
A
Q
G
G
R
S
C
I
T
S
R
V
Y
P
T
E
A
-
I
YGA
A
---
K
L
F
L
F
N
N
A
T
----
G
A
S
-
I
T
A
S
L
K
I
W
E
M
N
----
1
PsiBlast_PDB
79.79
29%
26
- C2 -
3PIG
3
?
A:
[14-501]
-------
I
R
D
H
A
A
E
L
A
K
A
E
A
G
V
A
E
M
A
A
K
R
N
N
RWYPK
Y
H
I
A
S
N
G
G
W
I
N
D
P
N
G
L
C
F
Y
K
G
R
W
H
V
F
Y
Q
L
H
P
Y
G
T
Q
W
G
-
P
M
H
W
G
H
V
S
S
T
D
M
L
N
W
K
R
E
P
I
M
F
A
P
S
L
E
-
Q
E
-
K
D
G
V
F
S
G
S
A
V
I
-
D
---------
D
----------
N
G-
D
L
-
R
F
Y
Y
T
G
H
R
WA
N
G
H
D
---
N
T
--------
G
G
D
-
W
Q
V
Q
M
T
A
----
L
P
D
N
-----
D
EL
T
S
---
A
T
K
---
Q
G
---
M
I
I
D
-
C
----
P
T-
D
----------
K
---
V
D
H
H
-
Y
R
D
P
K
-
V
W
-
K
T
--
G
--
D
T
W
Y
M
T
F
G
V
S
S
A
D
K
R
G
Q
M
W
L
F
S
S
K
D
M
V
R
W
-
E
Y
E
-
R
V
L
----
F
Q
H
P
D
P
D
V
F
M
L
E
C
P
D
F
S
-----
P
I
K
------------------
D
---------------
K
D
G
N
E
K
W
V
I
G
F
--
S
A
M
G
S
K
P
S
G
F
M
N
R
N
V
S
N
A
G
-
Y
M
I
G
T
W
E
P
G
G
E
F
K
P
E
T
---------
E
---------
F
R
L
W
D
C
G
H
N
---
Y
Y
A
P
Q
S
F
N
V
---
D
----
G
R
Q
I
V
Y
G
W
M
S
PFVQP
I
P
M
E
D
D
G
---------
W
C
G
Q
L
T
L
P
R
E
I
T
L
--
G
---
D
-
D
G--
D
V
V
T
A
P
V
A
E
M
E
G
L
R
E
DTL
D
H
G
S
V
--
T
-
L
D
M
D
G
E
Q
--
I
I
A
--
D
D
A
E
A
V
E
I
E
M
T
I
D
L
A
A
---
S
T
----------------------------
A
----------------------------
E
---------------
R
A
G
L
K
I
H
A
T
E
-
D
------
G
A
Y
T
Y
V
A
Y
D
G
----
Q
IGR------
V
-------
V
V
D
R
Q
A
M
A
N
-----
G
-----
D
R
-----
G
--
Y
R
--
A
A
P
L
----
T
D
A
E
L
A
SG
K
L
D
L
R
V
F
V
D
R
G
S
V
E
V
Y
V
N
G
G
H
Q
V
L
S
S
Y
S
Y
A
S
E
G
-
P
---
R
---
A
I
K
L
V
A
E
-
S
----
G
---
S
--------------
2
PsiBlast_PDB
79.20
29%
24
- C2 -
3PIJ
3
?
A:
[14-501]
-------
I
R
D
H
A
A
E
L
A
K
A
E
A
G
V
A
E
M
A
A
K
R
N
N
RWYPK
Y
H
I
A
S
N
G
G
W
I
N
D
P
N
G
L
C
F
Y
K
G
R
W
H
V
F
Y
Q
L
H
P
Y
G
T
Q
W
G
-
P
M
H
W
G
H
V
S
S
T
D
M
L
N
W
K
R
E
P
I
M
F
A
P
S
L
E
-
Q
E
-
K
D
G
V
F
S
G
S
A
V
I
-
D
---------
D
----------
N
G-
D
L
-
R
F
Y
Y
T
G
H
R
WA
N
G
H
D
---
N
T
--------
G
G
D
-
W
Q
V
Q
M
T
A
----
L
P
D
N
-----
D
EL
T
S
---
A
T
K
---
Q
G
---
M
I
I
D
-
C
----
P
T-
D
----------
K
---
V
D
H
H
-
Y
R
D
P
K
-
V
W
-
K
T
--
G
--
D
T
W
Y
M
T
F
G
V
S
S
A
D
K
R
G
Q
M
W
L
F
S
S
K
D
M
V
R
W
-
E
Y
E
-
R
V
L
----
F
Q
H
P
D
P
D
V
F
M
L
E
C
P
D
F
S
-----
P
I
K
------------------
D
---------------
K
D
G
N
E
K
W
V
I
G
F
--
S
A
M
G
S
K
P
S
G
F
M
N
R
N
V
S
N
A
G
-
Y
M
I
G
T
W
E
P
G
G
E
F
K
P
E
T
---------
E
---------
F
R
L
W
D
C
G
H
N
---
Y
Y
A
P
Q
S
F
N
V
---
D
----
G
R
Q
I
V
Y
G
W
M
S
PFVQP
I
P
M
E
D
D
G
---------
W
C
G
Q
L
T
L
P
R
E
I
T
L
--
G
---
D
-
D
G--
D
V
V
T
A
P
V
A
E
M
E
G
L
R
E
D
T
L
D
H
G
S
V
--
T
-
L
D
M
D
G
E
Q
--
I
I
A
--
D
D
A
E
A
V
E
I
E
M
T
I
D
L
A
A
---
S
T
----------------------------
A
----------------------------
E
---------------
R
A
G
L
K
I
H
A
T
E
-
D
------
G
A
Y
T
Y
V
A
Y
D
G
----
Q
IG
R
------
V
-------
V
V
D
R
Q
A
M
A
N
-----
G
-----
D
R
-----
G
--
Y
R
--
A
A
P
L
----
T
D
A
E
L
A
SG
K
L
D
L
R
V
F
V
D
R
G
S
V
E
V
Y
V
N
G
G
H
Q
V
L
S
S
Y
S
Y
A
S
E
G
-
P
---
R
---
A
I
K
L
V
A
E
-
S
----
G
---
S
--------------
31
HHSearch
77.12
24%
2
- C2 -
3SC7
4
INU2_ASPFI
X:
[24-514]
-----------------------
Q
S
N
D
Y
R
P
S
-----
Y
H
F
T
P
D
Q
Y
W
M
N
E
P
N
G
L
I
K
I
G
S
T
W
H
L
F
F
Q
H
N
P
T
A
N
V
W
G
N
I
-
C
W
G
H
A
T
S
T
D
L
M
H
W
A
H
K
P
T
A
I
A
D
E
N
-----
G
V
E
A
F
T
G
T
A
Y
Y
-
D
P--------
N
NTSGLGDSAN
P
--
P
Y
-
L
A
W
F
T
G
----
Y
T
T
S
--------------
S
Q
-
T
Q
D
Q
R
L
A
----
F
S
V
D
N----
G
--
A
T
---
W
T
K
---
F
Q
GN-
P
I
I
S
-
T
SQEA
P
--
H
DI--------
T
---
G
G
L
E
-
S
R
D
P
K
-
V
F
-
F
H
RQ
S
--
G
N
W
I
M
V
L
A
H
G
G
---
Q
D
K
L
S
F
W
T
S
A
D
T
I
N
W
-
T
W
Q
-
S
D
L
K
S
T
S
I
N
G
L
S
S
D
I
T
G
W
E
V
P
D
M
F
-----
E
L
P
VEGTEE------------
T
---------------
T
W
-----
V
V
M
M
--
T
P
A
E
G
S
P
A
-----
G
G
N
G
V
L
-
A
I
T
G
S
F
D
G
K
S
--
F
T
A
D
PVDA-----
S
---------
T
M
W
L
D
N
G
R
D
---
F
D
G
A
L
S
W
V
N
---
V
PAS
D
G
R
R
I
I
A
A
V
M
N
-----
S
Y
G
S
---
N
P
P
T
---
T
T
W
K
G
M
L
S
F
P
R
T
L
S
L
--
K
K--
V
-
G
TQQ
H
F
V
Q
Q
P
I
T
E
L
D
T
I
S
T
---
S
L
Q
I
L
--
A
--
N
Q
T
I
T
P
G
Q
T
L
L
SS
I
R
G
T
A
L
D
V
-----
R
V
A
F--
Y
P
----------------------------
D
----------------------------
A
---------------
G
S
V
L
S
L
A
V
R
K
-
G
ASEQ--
T
V
I
K
Y
T
Q
S
D
A
----
T
---------
L
-------
S
V
D
R
T
E
S
G
D
ISYDP
A
-----
A
G
-----
G
--
V
H
--
T
A
K
L
EEDG
T
G
L
V
S
------
I
R
V
L
V
D
T
C
S
V
E
V
F
G
G
Q
G
E
A
V
I
S
D
L
I
F
P
S
D
S
-
S
---
D
---
G
L
A
L
E
V
T
-
G
----
G
NA-
V
L
Q
S
V
D
V
R
S
V
S
----
33
HHSearch
76.25
26%
24
- C2 -
1Y4W
6
INUE_ASPAW
A:
[3-514]
-----------------------
Y
D
Q
P
Y
R
G
Q
-----
Y
H
F
S
P
Q
K
N
W
M
N
D
P
N
G
L
L
Y
H
N
G
T
Y
H
L
F
F
Q
Y
N
P
G
G
I
E
W
G
N
I
-
S
W
G
H
A
I
S
E
D
L
T
H
W
E
E
K
P
V
A
L
L
A
R
G
F
G
S
D
V
T
E
M
Y
F
S
G
S
A
V
A
-
D
VNNTSGFGK
D
----------
G
KT
P
L
-
V
A
M
Y
T
S
----
Y
Y
P
V
---
A
Q
T
L
PSG
Q
T
V
Q
E
D
-
Q
Q
S
Q
S
I
A
----
Y
S
L
D
D----
G
--
L
T
---
W
T
T
---
Y
D
AAN
P
V
I
P
N
P
----
P
--
S
----------
P
YEA
E
Y
Q
N
-
F
R
D
P
F
-
V
F
-
W
H
--
D
ES
Q
K
W
V
V
V
T
S
I
A
E
---
L
H
K
L
A
I
Y
T
S
D
N
L
K
D
W
-
K
L
V
-
S
E
F
G
P
Y
-----
N
A
Q
G
G
V
W
E
C
P
G
L
V
-----
K
L
P
L
D
SGN
S
------------
T
---------------
K
W
-----
V
I
T
S
--
G
L
N
P
G
G
P
P
G
---
T
V
G
S
G
T
Q
-
Y
F
V
G
E
F
D
G
T
--
T
F
T
P
D
ADTVYPGNS
T
---------
A
N
W
M
D
W
G
P
D
---
F
Y
A
A
A
G
Y
N
G
---
L
S--
L
N
D
H
V
H
I
G
W
M
N
-----
N
W
Q
Y
G
A
-
N
I
P
---
T
Y
P
W
R
S
A
M
A
I
P
R
H
M
A
L
--
K
T--
I
-
G
SKA
T
L
V
Q
Q
P
Q
E
A
W
S
S
I
S
N
---
K
R
P
I
Y
--
S
R
T
F
K
T
L
S
E
G
S
T
N
T
T
-
T
T
G
E
T
F
K
V
-----
D
L
S
F
--
S
A
----------------------------
K
S---------------------------
K
---------------
A
S
T
F
A
I
A
L
R
A
-
S
ANFT
E
Q
T
L
V
G
Y
D
F
A
K
Q
----
Q
---------
I
-------
F
L
D
R
T
H
S
G
D
V----
S
-----
F
D
ETFA-
S
--
V
Y
H
G
P
L
T
P
D
S--
T
G
V
V
K
------
L
S
I
F
V
D
R
S
S
V
E
V
F
G
G
Q
G
E
T
T
L
T
A
Q
I
F
P
S
S
D
-
A
---
V
---
H
A
R
L
A
S
T
-
G
----
G
T
T
-
E
D
V
R
A
D
I
Y
K
I
A
----
40
HHSearch
75.62
25%
-3
- C2 -
1ST8
6
?
A:
[3-529]
-----------------------
I
E
Q
P
Y
R
T
G
-----
Y
H
F
Q
P
P
S
N
W
M
N
D
P
N
G
P
M
L
Y
Q
G
V
Y
H
F
F
Y
Q
Y
N
P
Y
A
A
T
F
G
D
V
I
I
W
G
H
A
V
S
Y
D
L
V
N
W
I
H
L
D
P
A
I
Y
P
T
Q
E
-
A
D
-
S
K
S
C
W
S
G
S
A
T
I
-
L
P--------
G
----------
N
--
I
P
-
A
M
L
Y
T
G
----
S
D
S
K
---------------
S
-
R
Q
V
Q
D
L
A
----
W
P
K
N
LSDPF
L
--
R
E
---
W
V
K
---
H
P
KN-
P
L
I
T
-
P
----
P
--
E
----------
G
V--
K
D
D
C
-
F
R
D
P
S
-
T
A
-
W
L
G
P
D
--
G
V
W
R
I
V
V
G
G
D
R
D
-
N
N
G
M
A
F
L
Y
Q
S
T
D
F
V
N
W
-
K
R
Y
D
Q
P
L
S
S
A
------
D
A
T
G
T
W
E
C
P
D
F
Y
-----
P
V
P
------------------
L
NST
N
G
L
D
TSVYGGS
V
R
H
-----
V
M
K
A
--
G
F
E
------------
G
H
D
W
-
Y
T
I
G
T
Y
S
P
D
R
E
N
F
L
P
Q
---------
N
GLSLTGSTL
D
L
R
Y
D
Y
G
-
Q
---
F
Y
A
S
K
S
F
F
D
---
D
A--
K
N
R
R
V
L
W
A
W
V
P
-----
E
T
D
S
Q
---
A
D
D
-
I
E
K
G
W
A
G
L
Q
S
F
P
R
A
L
W
I
--
D
R--
N
-
G
K--
Q
L
I
Q
W
P
V
E
E
I
E
E
L
R
Q
---
N
Q
V
N
L
Q
-
N
-
K
N
L
K
P
-
G
S
V
L
E
I
H
G
I
A
A
S
Q
A
D
V
-----
T
I
S
F
--
K
L
----------------------------
E
GLKEAEVLDTTLVD
P
Q
A
L
C
N
E
R
GASSRG
A
---------------
L
G
P
F
G
L
L
A
M
A
-
S
KDLK
E
Q
S
A
I
F
F
R
V
F
Q
N
----
Q
---------
L
G
R
Y
S
V
L
M
C
S
D
L
S
R
S
T
V
RS---
N
IDT
T
S
Y
G
-----
A
--
F
V
--
D
I
D
P
R---
S
E
E
I
S
------
L
R
N
L
I
D
H
S
I
I
E
S
F
G
A
G
G
K
T
C
I
T
S
R
I
Y
P
K
F
V
-
N
---
N
E
E
A
H
L
F
V
F
N
N
-
G
----
T
Q
N
V
K
I
S
E
M
S
A
W
S
M
K
----
37
HHSearch
75.35
25%
15
- C2 -
2AC1
7
INV1_ARATH
A:
[5-536]
------------------------
N
Q
P
Y
R
T
G
-----
F
H
F
Q
P
P
K
N
W
M
N
D
P
N
G
P
M
I
Y
K
G
I
Y
H
L
F
Y
Q
W
N
P
K
G
A
V
W
G
N
I
-
V
W
A
H
S
T
S
T
D
L
I
N
W
D
P
H
P
P
A
I
F
P
S
A
P
-
F
D
-
I
N
G
C
W
S
G
S
A
T
I
-
L
P--------
N
----------
G
--
K
P
-
V
I
L
Y
T
G
----
I
D
P
K
---------------
N
-
Q
Q
V
Q
N
I
A
----
E
P
K
N
LSDPY
L
--
R
E
---
W
K
K
---
S
P
LN-
P
L
M
A
-
P
----
D
AV
N
G---------
I
---
N
A
S
S
-
F
R
D
P
T
-
T
A
-
W
L
G
Q
D
--
K
K
W
R
V
I
I
G
S
K
I
H
-
R
R
G
L
A
I
T
Y
T
S
K
D
F
L
K
W
-
E
K
S
-
P
E
P
L
H
Y
-----
D
D
G
S
G
M
W
E
C
P
D
F
F
-----
P
V
T
RFGS
N
G
V
E
TS
S
F
G
E
PN
E
I
L
---------------
K
H
-----
V
L
K
I
--
S
L
D
D
----------
T
K
H
D
Y
-
Y
T
I
G
T
Y
D
R
V
K
D
K
F
V
P
D
NGFKMDG--
T
---------
A
P
R
Y
D
Y
G
-
K
---
Y
Y
A
S
K
T
F
F
D
---
S
A--
K
N
R
R
I
L
W
G
W
T
N
-----
E
S
S
S
V
---
E
D
D
-
V
E
K
G
W
S
G
I
Q
T
I
P
R
K
I
W
L
--
D
R--
S
-
G
K--
Q
L
I
Q
W
P
V
R
E
V
E
R
L
R
T
---
K
Q
V
K
N
L
R
N
-
K
V
L
K
S
-
G
S
R
L
E
V
Y
G
V
T
A
A
Q
A
D
V
-----
E
V
L
F
--
K
V
R
DLEKADVIEPSWTD
P
Q
L
I
C
S
K
M
NVSVK
S
----------------------------
G
---------------
L
G
P
F
G
L
M
V
L
A
-
S
KNLE
E
Y
T
S
V
Y
F
R
I
F
K
A
----
R
QNSN
K
Y
V
V
L
M
-------
C
S
D
Q
S
R
S
S
L
KE---
D
-----
N
D
K----
T
T
Y
G
A
--
F
V
D
I
NP--
H
Q
P
L
S
------
L
R
A
L
I
D
H
S
V
V
E
S
F
G
G
K
G
R
A
C
I
T
S
R
V
Y
P
K
L
A
I
G
---
K
---
S
S
H
L
F
A
F
-
N
YGY
Q
S
V
--
D
V
L
N
L
N
A
W
S
M
N
----
3
PsiBlast_PDB
75.35
33%
9
- C2 -
1UYP
6
BFRA_THEMA
A:
[3-396]
----------------------------
K
P
N
-----
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
-
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
---
E
-
T
H
G
V
F
S
G
S
A
V
E
-
K
---------
D
----------
G
--
K
M
-
F
L
V
Y
T
-----
Y
Y
R
D
P
T
H
N
K
--------
G
E
K
-
E
T
-
Q
C
V
V
----
M
S
E
N
-----
G
--
L
D
---
F
V
K
Y
DG
N
P
---
V
I
S
K
-
P
----
P
--
E
----------
E
---
G
T
H
A
-
F
R
D
P
K
-
V
N
-
R
S
--
N
--
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
-
K
Y
E
-
G
A
I
F
E
------
D
E
T
T
K
E
I
E
C
P
D
L
V
-----
R
I
G
------------------
E
---------------
K
D
-----
I
L
I
Y
--
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
E
------
G
K
L
N
V
E
K
R
G
L
-------------------------
L
D
H
G
T
D
---
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
-----
S
W
L
R
T
-
G
L
Y
P
T
-
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
--
E
---
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
K
-----
R
K
V
--
F
-
E
T
A
K
S
G
T
F
L
L
D
V
---
K
E
N
S
Y
E
I
-----
V
C
E
F
S
G
E
I
----------------------------
E
----------------------------
L
---------------
R
M
G
---
N
E
S
E
-
E
------
V
V
I
T
K
S
R
D
E
L
----
I
---------
V
-------
D
T
T
R
S
G
V
S
G
------------
G
-----
E
--
V
R
--
K
S
T
V
----
E
D
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
-------------------------------------------------------
51
Fugue
75.20
29%
19
- C2 -
1UYP
6
BFRA_THEMA
A:
[1-432]
--------------------------
L
F
K
P
N
-----
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
-
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
---
E
-
T
H
G
V
F
S
G
S
A
V
E
-
K
---------
D
----------
G
--
K
M
-
F
L
V
Y
T
Y
----
Y
R
D
P
---
T
H
--------
N
K
G
E
K
E
T
Q
C
V
V
----
M
S
E
N
-----
G
--
L
D
---
F
V
K
---
Y
D
GNP
V
I
S
K
-
P
----
P
--
E
----------
E
---
G
T
H
A
-
F
R
D
P
K
-
V
N
-
R
S
--
N
--
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
-
K
Y
E
-
G
A
I
F
E
D
------
E
T
T
K
E
I
E
C
P
D
L
V
-----
R
I
G
------------------
E
---------------
K
D
-----
I
L
I
Y
--
S
I
T
S
T
----------
N
S
V
L
-
F
S
M
G
E
L
K
E
G
--
K
L
N
V
E
---------
K
---------
R
G
L
L
D
H
G
T
D
---
F
Y
A
A
Q
T
F
F
G
---
T
----
D
R
V
V
V
I
G
W
L
Q
-----
S
W
L
R
T
G
L
-
Y
P
T
-
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
--
E
---
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
K
---
R
K
V
F
E
--
T
-
A
K
S
G
T
F
L
L
D
V
K
-----
E
N
S
Y
E
I
-----
V
C
E
---
F
S
----------------------------
G
----------------------------
E
---------------
I
E
L
R
M
G
N
E
S
E
-
E
------
V
V
I
T
K
S
R
D
E
L
----
I
---------
V
-------
D
T
T
R
S
G
V
S
G
-----
G
-----
E
V
-----
R
--
K
S
--
T
V
E
D
----
E
A
T
N
R
------
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
S
-
I
A
F
S
F
R
I
H
P
E
N
V
-
Y
---
N
---
I
L
S
V
K
S
N
-
Q
----------
V
K
L
E
V
F
E
L
E
NIWL
24
PsiBlast_CBE
75.03
33%
11
- C2 -
1UYP
4
BFRA_THEMA
C:
[3-396]
----------------------------
K
P
N
-----
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
-
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
---
E
-
T
H
G
V
F
S
G
S
A
V
E
-
K
---------
D
----------
G
--
K
M
-
F
L
V
Y
T
-----
Y
Y
R
D
PTH
N
K
--------
G
E
K
-
E
T
-
Q
C
V
V
----
M
S
E
N
-----
G
--
L
D
---
F
V
K
YDG
N
P
---
V
I
S
K
-
P
----
P
--
E
----------
E
---
G
T
H
A
-
F
R
D
P
K
-
V
N
-
R
S
--
N
--
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
-
K
Y
E
-
G
A
I
F
E
------
D
E
T
T
K
E
I
E
C
P
D
L
V
-----
R
I
G
------------------
E
---------------
K
D
-----
I
L
I
Y
--
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
E
------
G
K
L
N
V
E
K
R
G
L
-------------------------
L
D
H
G
T
D
---
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
-----
S
W
L
R
T
-
G
L
Y
P
T
-
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
--
E
---
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
K
-----
R
K
V
--
F
-
E
T
A
K
S
G
T
F
L
L
D
V
---
K
E
N
S
Y
E
I
-----
V
C
E
FSG
E
I
----------------------------
E
----------------------------
L
---------------
R
M
G
---
N
E
S
E
-
E
------
V
V
I
T
K
S
R
D
E
L
----
I
---------
V
-------
D
T
T
R
S
G
V
S
G
------------
G
-----
E
--
V
R
--
K
S
T
V
----
E
D
E
A
T
NR----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
-------------------------------------------------------
41
HHSearch
74.84
22%
-4
- C2 -
4FFH
1
?
A:
[2-479]
-----------------------------
A
V
-----
Y
H
M
T
P
P
S
G
W
L
C
N
P
Q
R
P
V
T
T
H
G
A
Y
Q
L
Y
Y
L
H
S
D
Q
N
N
-
G
P
-
G
-
G
W
D
H
A
S
T
T
D
G
V
A
F
T
H
H
G
T
V
M
P
L
R
P
-----
D
F
P
V
W
S
G
S
A
V
V
-
D
T--------
A
NTAGFGA---
G
--
A
V
-
V
A
L
A
T
Q
----
P
T
D
G
-------------
V
R
K
-
Y
Q
E
Q
Y
L
Y
----
W
S
T
D
G----
G
--
F
T
---
F
T
A
---
L
P
D--
P
V
I
V
-
N
----
T
--
D
G
R
A
ATT
P
A
E
I
E
---
N
A
E
W
-
F
R
D
P
K
-
I
H
-
W
D
TA
R
--
G
E
W
V
C
V
I
G
R
L
-----
R
Y
A
A
F
Y
T
S
P
N
L
R
D
W
-
T
L
R
-
R
N
F
D
Y
P
-----
N
H
A
L
G
G
I
E
C
P
D
L
F
-----
E
I
T
A
DDG
T
-------------
R
---------------
H
W
-----
V
L
A
A
--
S
M
D
A
Y
G
I
-----
G
L
P
M
T
Y
A
-
Y
W
T
G
T
W
D
G
E
--
Q
F
H
A
D
DL-------
T
---------
P
Q
W
L
D
W
G
W
D
---
W
Y
A
A
V
T
W
P
S
IDA
P
---
E
T
K
R
L
A
I
A
W
M
N
-----
N
W
K
Y
A
A
R
D
V
P
T
D
A
S
D
G
Y
N
G
Q
N
S
I
V
R
E
L
R
L
--
A
R
Q
P
G
-
G
W
Y
-
T
L
L
S
T
P
V
A
A
L
T
N
Y
V
T
---
A
T
T
T
L
--
P
D
R
T
V
D
--
G
S
A
V
L
P
--
W
N
G
R
A
Y
E
I
-----
E
L
D
I
--
A
W
----------------------------
D
----------------------------
T
---------------
A
T
N
V
G
I
S
V
G
R
-
S
PDGT
R
H
T
N
I
G
K
Y
--
G
A
----
D
---------
L
-------
Y
V
D
R
G
P
S
D
L
A----
G
-----
Y
S
LAPYS
R
A
-
A
A
--
P
I
D
P
G---
A
R
S
V
H
------
L
R
I
L
V
D
T
Q
S
V
E
V
F
V
N
A
G
H
T
V
L
S
Q
Q
V
H
F
A
E
G
-
D
---
T
---
G
I
S
L
Y
T
D
-
G
----
G
P
A
-
H
F
T
G
I
V
V
R
E
I
G
----
21
PsiBlast_CBE
74.82
33%
9
- C2 -
1UYP
5
BFRA_THEMA
F:
[3-396]
----------------------------
K
P
N
-----
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
-
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
---
E
-
T
H
G
V
F
S
G
S
A
V
E
-
K
---------
D
----------
G
--
K
M
-
F
L
V
Y
T
-----
Y
Y
R
D
PTH
N
K
--------
G
E
K
-
E
T
-
Q
C
V
V
----
M
S
E
N
-----
G
--
L
D
---
F
V
K
YDG
N
P
---
V
I
S
K
-
P
----
P
--
E
----------
E
---
G
T
H
A
-
F
R
D
P
K
-
V
N
-
R
S
--
N
--
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
-
K
Y
E
-
G
A
I
F
E
------
D
E
T
T
K
E
I
E
C
P
D
L
V
-----
R
I
G
------------------
E
---------------
K
D
-----
I
L
I
Y
--
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
E
------
G
K
L
N
V
E
K
R
G
L
-------------------------
L
D
H
G
T
D
---
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
-----
S
W
L
R
T
-
G
L
Y
P
T
-
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
--
E
---
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
K
-----
R
K
V
--
F
-
E
T
A
K
S
G
T
F
L
L
D
V
---
K
E
N
S
Y
E
I
-----
V
C
E
FSG
E
I
----------------------------
E
----------------------------
L
---------------
R
M
G
---
N
E
S
E
-
E
------
V
V
I
T
K
S
R
D
E
L
----
I
---------
V
-------
D
T
T
R
S
G
V
S
G
------------
G
-----
E
--
V
R
--
K
S
T
V
----
E
D
E
A
T
NR----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
-------------------------------------------------------
26
PsiBlast_CBE
74.58
32%
12
- C2 -
1W2T
1
BFRA_THEMA
F:
[3-396]
----------------------------
K
P
N
-----
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
-
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
---
E
-
T
H
G
V
F
S
G
S
A
V
E
-
K
---------
D
----------
G
--
K
M
-
F
L
V
Y
T
-----
Y
Y
R
D
PTH
N
K
--------
G
E
K
-
E
T
-
Q
C
V
V
----
M
S
E
N
-----
G
--
L
D
---
F
V
K
YDG
N
P
---
V
I
S
K
-
P
----
P
--
E
----------
E
---
G
T
H
A
-
F
R
D
P
K
-
V
N
-
R
S
--
N
--
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
-
K
Y
E
-
G
A
I
F
E
------
D
E
T
T
K
E
I
D
C
P
D
L
V
-----
R
I
G
------------------
E
---------------
K
D
-----
I
L
I
Y
--
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
E
------
G
K
L
N
V
E
K
R
G
L
-------------------------
L
D
H
G
T
D
---
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
-----
S
W
L
R
-
T
G
L
Y
P
T
-
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
--
E
---
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
K
---
R
K
-------
V
F
E
T
A
K
S
G
T
F
L
L
--
D
V
K
E
N
S
Y
E
-----
I
V
C
---
E
F
----------------------------
S
----------------------------
G
---------------
E
I
E
L
R
M
G
N
E
S
E
E
------
V
V
I
T
K
S
R
D
E
L
----
I
---------
V
-------
D
T
T
R
S
G
V
S
G
------------
G
-----
E
--
V
R
--
K
S
T
V
----
E
D
E
A
T
NR----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
-------------------------------------------------------
22
PsiBlast_CBE
74.28
33%
10
- C2 -
1UYP
1
BFRA_THEMA
E:
[3-396]
----------------------------
K
P
N
-----
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
-
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
---
E
-
T
H
G
V
F
S
G
S
A
V
E
-
K
---------
D
----------
G
--
K
M
-
F
L
V
Y
T
-----
Y
Y
R
D
PTH
N
K
--------
G
E
K
-
E
T
-
Q
C
V
V
----
M
S
E
N
-----
G
--
L
D
---
F
V
K
YDG
N
P
---
V
I
S
K
-
P
----
P
--
E
----------
E
---
G
T
H
A
-
F
R
D
P
K
-
V
N
-
R
S
--
N
--
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
-
K
Y
E
-
G
A
I
F
E
------
D
E
T
T
K
E
I
E
C
P
D
L
V
-----
R
I
G
------------------
E
---------------
K
D
-----
I
L
I
Y
--
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
E
------
G
K
L
N
V
E
K
R
G
L
-------------------------
L
D
H
G
T
D
---
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
-----
S
W
L
R
T
-
G
L
Y
P
T
-
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
--
E
---
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
K
-----
R
K
V
--
F
-
E
T
A
K
S
G
T
F
L
L
D
V
---
K
E
N
S
Y
E
I
-----
V
C
E
FSG
E
I
----------------------------
E
----------------------------
L
---------------
R
M
G
---
N
E
S
E
-
E
------
V
V
I
T
K
S
R
D
E
L
----
I
---------
V
-------
D
T
T
R
S
G
V
S
G
------------
G
-----
E
--
V
R
--
K
S
T
V
----
E
D
E
A
T
NR----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
-------------------------------------------------------
25
PsiBlast_CBE
74.16
33%
10
- C2 -
1UYP
5
BFRA_THEMA
B:
[3-396]
----------------------------
K
P
N
-----
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
-
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
---
E
-
T
H
G
V
F
S
G
S
A
V
E
-
K
---------
D
----------
G
--
K
M
-
F
L
V
Y
T
-----
Y
Y
R
D
PTH
N
K
--------
G
E
K
-
E
T
-
Q
C
V
V
----
M
S
E
N
-----
G
--
L
D
---
F
V
K
YDG
N
P
---
V
I
S
K
-
P
----
P
--
E
----------
E
---
G
T
H
A
-
F
R
D
P
K
-
V
N
-
R
S
--
N
--
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
-
K
Y
E
-
G
A
I
F
E
------
D
E
T
T
K
E
I
E
C
P
D
L
V
-----
R
I
G
------------------
E
---------------
K
D
-----
I
L
I
Y
--
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
E
------
G
K
L
N
V
E
K
R
G
L
-------------------------
L
D
H
G
T
D
---
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
-----
S
W
L
R
T
-
G
L
Y
P
T
-
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
--
E
---
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
K
-----
R
K
V
--
F
-
E
T
A
K
S
G
T
F
L
L
D
V
---
K
E
N
S
Y
E
I
-----
V
C
E
FSG
E
I
----------------------------
E
----------------------------
L
---------------
R
M
G
---
N
E
S
E
-
E
------
V
V
I
T
K
S
R
D
E
L
----
I
---------
V
-------
D
T
T
R
S
G
V
S
G
------------
G
-----
E
--
V
R
--
K
S
T
V
----
E
D
E
A
T
NR----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
-------------------------------------------------------
4
PsiBlast_PDB
73.95
32%
14
- C2 -
1W2T
2
BFRA_THEMA
A:
[3-396]
----------------------------
K
P
N
-----
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
-
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
---
E
-
T
H
G
V
F
S
G
S
A
V
E
-
K
---------
D
----------
G
--
K
M
-
F
L
V
Y
T
-----
Y
Y
R
D
P
T
H
N
K
--------
G
E
K
-
E
T
-
Q
C
V
V
----
M
S
E
N
-----
G
--
L
D
---
F
V
K
Y
DG
N
P
---
V
I
S
K
-
P
----
P
--
E
----------
E
---
G
T
H
A
-
F
R
D
P
K
-
V
N
-
R
S
--
N
--
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
-
K
Y
E
-
G
A
I
F
E
------
D
E
T
T
K
E
I
D
C
P
D
L
V
-----
R
I
G
------------------
E
---------------
K
D
-----
I
L
I
Y
--
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
E
------
G
K
L
N
V
E
K
R
G
L
-------------------------
L
D
H
G
T
D
---
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
-----
S
W
L
R
-
T
G
L
Y
P
T
-
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
--
E
---
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
K
---
R
K
-------
V
F
E
T
A
K
S
G
T
F
L
L
--
D
V
K
E
N
S
Y
E
-----
I
V
C
---
E
F
----------------------------
S
----------------------------
G
---------------
E
I
E
L
R
M
G
N
E
S
E
E
------
V
V
I
T
K
S
R
D
E
L
----
I
---------
V
-------
D
T
T
R
S
G
V
S
G
------------
G
-----
E
--
V
R
--
K
S
T
V
----
E
D
E
A
T
N
R
----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
-------------------------------------------------------
27
PsiBlast_CBE
73.66
32%
14
- C2 -
1W2T
2
BFRA_THEMA
E:
[3-396]
----------------------------
K
P
N
-----
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
-
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
---
E
-
T
H
G
V
F
S
G
S
A
V
E
-
K
---------
D
----------
G
--
K
M
-
F
L
V
Y
T
-----
Y
Y
R
D
PTH
N
K
--------
G
E
K
-
E
T
-
Q
C
V
V
----
M
S
E
N
-----
G
--
L
D
---
F
V
K
YDG
N
P
---
V
I
S
K
-
P
----
P
--
E
----------
E
---
G
T
H
A
-
F
R
D
P
K
-
V
N
-
R
S
--
N
--
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
-
K
Y
E
-
G
A
I
F
E
------
D
E
T
T
K
E
I
D
C
P
D
L
V
-----
R
I
G
------------------
E
---------------
K
D
-----
I
L
I
Y
--
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
E
------
G
K
L
N
V
E
K
R
G
L
-------------------------
L
D
H
G
T
D
---
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
-----
S
W
L
R
-
T
G
L
Y
P
T
-
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
--
E
---
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
K
---
R
K
-------
V
F
E
T
A
K
S
G
T
F
L
L
--
D
V
K
E
N
S
Y
E
-----
I
V
C
---
E
F
----------------------------
S
----------------------------
G
---------------
E
I
E
L
R
M
G
N
E
S
E
E
------
V
V
I
T
K
S
R
D
E
L
----
I
---------
V
-------
D
T
T
R
S
G
V
S
G
------------
G
-----
E
--
V
R
--
K
S
T
V
----
E
D
E
A
T
NR----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
-------------------------------------------------------
23
PsiBlast_CBE
73.21
33%
13
- C2 -
1UYP
2
BFRA_THEMA
D:
[3-396]
----------------------------
K
P
N
-----
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
-
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
---
E
-
T
H
G
V
F
S
G
S
A
V
E
-
K
---------
D
----------
G
--
K
M
-
F
L
V
Y
T
-----
Y
Y
R
D
PTH
N
K
--------
G
E
K
-
E
T
-
Q
C
V
V
----
M
S
E
N
-----
G
--
L
D
---
F
V
K
YDG
N
P
---
V
I
S
K
-
P
----
P
--
E
----------
E
---
G
T
H
A
-
F
R
D
P
K
-
V
N
-
R
S
--
N
--
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
-
K
Y
E
-
G
A
I
F
E
------
D
E
T
T
K
E
I
E
C
P
D
L
V
-----
R
I
G
------------------
E
---------------
K
D
-----
I
L
I
Y
--
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
E
------
G
K
L
N
V
E
K
R
G
L
-------------------------
L
D
H
G
T
D
---
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
-----
S
W
L
R
T
-
G
L
Y
P
T
-
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
--
E
---
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
K
-----
R
K
V
--
F
-
E
T
A
K
S
G
T
F
L
L
D
V
---
K
E
N
S
Y
E
I
-----
V
C
E
FSG
E
I
----------------------------
E
----------------------------
L
---------------
R
M
G
---
N
E
S
E
-
E
------
V
V
I
T
K
S
R
D
E
L
----
I
---------
V
-------
D
T
T
R
S
G
V
S
G
------------
G
-----
E
--
V
R
--
K
S
T
V
----
E
D
E
A
T
NR----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
-------------------------------------------------------
28
PsiBlast_CBE
73.06
32%
13
- C2 -
1W2T
1
BFRA_THEMA
D:
[3-396]
----------------------------
K
P
N
-----
Y
H
F
F
P
I
T
G
W
M
N
D
P
N
G
L
I
F
W
K
G
K
Y
H
M
F
Y
Q
Y
N
P
R
K
P
E
W
G
-
N
I
C
W
G
H
A
V
S
D
D
L
V
H
W
R
H
L
P
V
A
L
Y
P
D
D
---
E
-
T
H
G
V
F
S
G
S
A
V
E
-
K
---------
D
----------
G
--
K
M
-
F
L
V
Y
T
-----
Y
Y
R
D
PTH
N
K
--------
G
E
K
-
E
T
-
Q
C
V
V
----
M
S
E
N
-----
G
--
L
D
---
F
V
K
YDG
N
P
---
V
I
S
K
-
P
----
P
--
E
----------
E
---
G
T
H
A
-
F
R
D
P
K
-
V
N
-
R
S
--
N
--
G
E
W
R
M
V
L
G
S
G
K
D
E
K
I
G
R
V
L
L
Y
T
S
D
D
L
F
H
W
-
K
Y
E
-
G
A
I
F
E
------
D
E
T
T
K
E
I
D
C
P
D
L
V
-----
R
I
G
------------------
E
---------------
K
D
-----
I
L
I
Y
--
S
I
T
S
T
N
S
V
L
F
S
M
G
E
L
K
E
------
G
K
L
N
V
E
K
R
G
L
-------------------------
L
D
H
G
T
D
---
F
Y
A
A
Q
T
F
F
G
---
T
---
D
-
R
V
V
V
I
G
W
L
Q
-----
S
W
L
R
-
T
G
L
Y
P
T
-
K
R
E
G
W
N
G
V
M
S
L
P
R
E
L
Y
V
--
E
---
N
-
N
---
E
L
K
V
K
P
V
D
E
L
L
A
L
R
K
---
R
K
-------
V
F
E
T
A
K
S
G
T
F
L
L
--
D
V
K
E
N
S
Y
E
-----
I
V
C
---
E
F
----------------------------
S
----------------------------
G
---------------
E
I
E
L
R
M
G
N
E
S
E
E
------
V
V
I
T
K
S
R
D
E
L
----
I
---------
V
-------
D
T
T
R
S
G
V
S
G
------------
G
-----
E
--
V
R
--
K
S
T
V
----
E
D
E
A
T
NR----
I
R
A
F
L
D
S
C
S
V
E
F
F
F
N
D
-------------------------------------------------------
9
PsiBlast_PDB
58.99
30%
7
- C2 -
2ADD
2
?
A:
[6-345]
--------------------------
P
Y
R
T
G
-----
Y
H
F
Q
P
P
S
N
W
M
N
D
P
N
G
P
M
L
Y
Q
G
V
Y
H
F
F
Y
Q
Y
N
P
Y
A
A
T
F
G
D
V
I
I
W
G
H
A
V
S
Y
D
L
V
N
W
I
H
L
D
P
A
I
Y
P
T
Q
E
-
A
D
-
S
K
S
C
W
S
G
S
A
T
I
-
L
---------
P
----------
G
--
N
I
P
A
M
L
Y
T
G
----
S
-------
D
--------
S
K
S
-
R
Q
V
Q
D
L
A
W
P
KN
L
S
D
P
-----
F
--
L
R
E
W
V
K
H
P
---
K
N
---
P
L
I
T
-
P
----
P
--
E
----------
G
---
V
K
D
D
C
F
R
D
P
S
T
A
W
L
G
P
--
D
--
G
V
W
R
I
V
V
G
G
D
R
D
N
-
N
G
M
A
F
L
Y
Q
S
T
D
F
V
N
W
K
R
Y
D
-
Q
P
L
S
S
A
D
A
T
G
------
T
W
E
C
P
D
F
Y
P
V
P
L
N
S
T
N
------------------
G
---------------
L
D
-----
T
S
V
Y
GG
S
V
R
H
V
M
K
A
G
F
E
G
H
D
W
Y
T
I
G
T
Y
S
P
D
R
E
N
F
L
P
Q
N
G
L
S
L
---------
T
---------
G
S
T
L
D
L
R
Y
D
YGQ
F
Y
A
S
K
S
F
F
D
---
D
A--
K
N
R
R
V
L
W
A
W
-------
V
P
E
T
D
S
Q
A
D
-
D
-
I
E
K
G
W
A
G
L
Q
S
F
P
R
A
L
W
I
D
R
N
---
G
-
K
---
Q
L
I
Q
W
P
V
E
E
I
E
E
L
R
Q
---
N
Q
V
N
L
--
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
58.62
30%
9
- C2 -
2AEZ
2
?
A:
[6-345]
--------------------------
P
Y
R
T
G
-----
Y
H
F
Q
P
P
S
N
W
M
N
D
P
N
G
P
M
L
Y
Q
G
V
Y
H
F
F
Y
Q
Y
N
P
Y
A
A
T
F
G
D
V
I
I
W
G
H
A
V
S
Y
D
L
V
N
W
I
H
L
D
P
A
I
Y
P
T
Q
E
-
A
D
-
S
K
S
C
W
S
G
S
A
T
I
-
L
---------
P
----------
G
--
N
I
P
A
M
L
Y
T
G
----
S
-------
D
--------
S
K
S
-
R
Q
V
Q
D
L
A
W
P
KN
L
S
D
P
-----
F
--
L
R
E
W
V
K
H
P
---
K
N
---
P
L
I
T
-
P
----
P
--
E
----------
G
---
V
K
D
D
C
F
R
D
P
S
T
A
W
L
G
P
--
D
--
G
V
W
R
I
V
V
G
G
D
R
D
N
-
N
G
M
A
F
L
Y
Q
S
T
D
F
V
N
W
K
R
Y
D
-
Q
P
L
S
S
A
D
A
T
G
------
T
W
Q
C
P
D
F
Y
P
V
P
L
N
S
T
N
------------------
G
---------------
L
D
-----
T
S
V
Y
GG
S
V
R
H
V
M
K
A
G
F
E
G
H
D
W
Y
T
I
G
T
Y
S
P
D
R
E
N
F
L
P
Q
N
G
L
S
L
---------
T
---------
G
S
T
L
D
L
R
Y
D
YGQ
F
Y
A
S
K
S
F
F
D
---
D
A--
K
N
R
R
V
L
W
A
W
-------
V
P
E
T
D
S
Q
A
D
-
D
-
I
E
K
G
W
A
G
L
Q
S
F
P
R
A
L
W
I
D
R
N
---
G
-
K
---
Q
L
I
Q
W
P
V
E
E
I
E
E
L
R
Q
---
N
Q
V
N
L
--
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
58.00
30%
8
- C2 -
1ST8
5
?
A:
[6-345]
--------------------------
P
Y
R
T
G
-----
Y
H
F
Q
P
P
S
N
W
M
N
D
P
N
G
P
M
L
Y
Q
G
V
Y
H
F
F
Y
Q
Y
N
P
Y
A
A
T
F
G
D
V
I
I
W
G
H
A
V
S
Y
D
L
V
N
W
I
H
L
D
P
A
I
Y
P
T
Q
E
-
A
D
-
S
K
S
C
W
S
G
S
A
T
I
-
L
---------
P
----------
G
--
N
I
P
A
M
L
Y
T
G
----
S
-------
D
--------
S
K
S
-
R
Q
V
Q
D
L
A
W
P
KN
L
S
D
P
-----
F
--
L
R
E
W
V
K
H
P
---
K
N
---
P
L
I
T
-
P
----
P
--
E
----------
G
---
V
K
D
D
C
F
R
D
P
S
T
A
W
L
G
P
--
D
--
G
V
W
R
I
V
V
G
G
D
R
D
N
-
N
G
M
A
F
L
Y
Q
S
T
D
F
V
N
W
K
R
Y
D
-
Q
P
L
S
S
A
D
A
T
G
------
T
W
E
C
P
D
F
Y
P
V
P
L
N
S
T
N
------------------
G
---------------
L
D
-----
T
S
V
Y
GG
S
V
R
H
V
M
K
A
G
F
E
G
H
D
W
Y
T
I
G
T
Y
S
P
D
R
E
N
F
L
P
Q
N
G
L
S
L
---------
T
---------
G
S
T
L
D
L
R
Y
D
YGQ
F
Y
A
S
K
S
F
F
D
---
D
A--
K
N
R
R
V
L
W
A
W
-------
V
P
E
T
D
S
Q
A
D
-
D
-
I
E
K
G
W
A
G
L
Q
S
F
P
R
A
L
W
I
D
R
N
---
G
-
K
---
Q
L
I
Q
W
P
V
E
E
I
E
E
L
R
Q
---
N
Q
V
N
L
--
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.33
30%
9
- C2 -
2ADE
2
?
A:
[6-345]
--------------------------
P
Y
R
T
G
-----
Y
H
F
Q
P
P
S
N
W
M
N
D
P
N
G
P
M
L
Y
Q
G
V
Y
H
F
F
Y
Q
Y
N
P
Y
A
A
T
F
G
D
V
I
I
W
G
H
A
V
S
Y
D
L
V
N
W
I
H
L
D
P
A
I
Y
P
T
Q
E
-
A
D
-
S
K
S
C
W
S
G
S
A
T
I
-
L
---------
P
----------
G
--
N
I
P
A
M
L
Y
T
G
----
S
-------
D
--------
S
K
S
-
R
Q
V
Q
D
L
A
W
P
KN
L
S
D
P
-----
F
--
L
R
E
W
V
K
H
P
---
K
N
---
P
L
I
T
-
P
----
P
--
E
----------
G
---
V
K
D
D
C
F
R
D
P
S
T
A
W
L
G
P
--
D
--
G
V
W
R
I
V
V
G
G
D
R
D
N
-
N
G
M
A
F
L
Y
Q
S
T
D
F
V
N
W
K
R
Y
D
-
Q
P
L
S
S
A
D
A
T
G
------
T
W
E
C
P
D
F
Y
P
V
P
L
N
S
T
N
------------------
G
---------------
L
D
-----
T
S
V
Y
GG
S
V
R
H
V
M
K
A
G
F
E
G
H
D
W
Y
T
I
G
T
Y
S
P
D
R
E
N
F
L
P
Q
N
G
L
S
L
---------
T
---------
G
S
T
L
D
L
R
Y
D
YGQ
F
Y
A
S
K
S
F
F
D
---
D
A--
K
N
R
R
V
L
W
A
W
-------
V
P
E
T
D
S
Q
A
D
-
D
-
I
E
K
G
W
A
G
L
Q
S
F
P
R
A
L
W
I
D
R
N
---
G
-
K
---
Q
L
I
Q
W
P
V
E
E
I
E
E
L
R
Q
---
N
Q
V
N
L
--
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
57.15
30%
7
- C2 -
2AEY
2
?
A:
[6-345]
--------------------------
P
Y
R
T
G
-----
Y
H
F
Q
P
P
S
N
W
M
N
D
P
N
G
P
M
L
Y
Q
G
V
Y
H
F
F
Y
Q
Y
N
P
Y
A
A
T
F
G
D
V
I
I
W
G
H
A
V
S
Y
D
L
V
N
W
I
H
L
D
P
A
I
Y
P
T
Q
E
-
A
D
-
S
K
S
C
W
S
G
S
A
T
I
-
L
---------
P
----------
G
--
N
I
P
A
M
L
Y
T
G
----
S
-------
D
--------
S
K
S
-
R
Q
V
Q
D
L
A
W
P
KN
L
S
D
P
-----
F
--
L
R
E
W
V
K
H
P
---
K
N
---
P
L
I
T
-
P
----
P
--
E
----------
G
---
V
K
D
D
C
F
R
D
P
S
T
A
W
L
G
P
--
D
--
G
V
W
R
I
V
V
G
G
D
R
D
N
-
N
G
M
A
F
L
Y
Q
S
T
D
F
V
N
W
K
R
Y
D
-
Q
P
L
S
S
A
D
A
T
G
------
T
W
E
C
P
D
F
Y
P
V
P
L
N
S
T
N
------------------
G
---------------
L
D
-----
T
S
V
Y
GG
S
V
R
H
V
M
K
A
G
F
E
G
H
D
W
Y
T
I
G
T
Y
S
P
D
R
E
N
F
L
P
Q
N
G
L
S
L
---------
T
---------
G
S
T
L
D
L
R
Y
D
YGQ
F
Y
A
S
K
S
F
F
D
---
D
A--
K
N
R
R
V
L
W
A
W
-------
V
P
E
T
D
S
Q
A
D
-
D
-
I
E
K
G
W
A
G
L
Q
S
F
P
R
A
L
W
I
D
R
N
---
G
-
K
---
Q
L
I
Q
W
P
V
E
E
I
E
E
L
R
Q
---
N
Q
V
N
L
--
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------