@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1274: (2016-04-30 )
MRRKVRRLTLAVSALVALFPAVAGCSDSGDNKPGATIPSTPANAEGRHGPFFPQCGGVSDQTVTELTRVTGLVNTAKNSVGCQWLAGGGILGPHFSFSWYRGSPIGRERKTEELSRASVEDINIDGHSGFIAIGNEPSLGDSLCEVGIQFSDDFIEWSVSFSQKPFPLPCDIAKELTRQSIANSK
Atome Classification :
(16 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10-------.-.......-.20...-.....30---........40....-....50........60....----.---....70----.-.--......80.........90.----------.......100--..--.....110...-....120.......130.-.--....--.----140..---.....150----.....--...160-....-...170.......180...--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRR
K
V
R
R
L
T
L
--------
A
-
V
S
A
L
V
A
L
-
F
P
A
VAG-CSDSGDN---KPGATIPSTPANAE-GRHGPFFPQCGGVS
D
-
Q
T
V
T
----
E
---
L
T
R
V
T
G
----
L
-
V
--
N
TAKNSV-G
C
Q
W
LAGGGILG----------PHF
S
F
S
WYRG--SP--IGR
E
R
K
T
E
E
L
S-RASV
E
D
I
N
IDGHS
G
F
I
A
I-G--NEPS--L----
G
D
S
L
C
---
E
V
G
I
Q
FS-----DD
F
I
E
--
W
S
VSFS-QKPF-PL
P
C
D
I
A
K
E
L
T
R
Q
S
IANSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Fugue
83.55
22%
-25
* C8 *
4NUZ
1
?
A:
[1-892]
MKIPEKIPMKPLHGP
L
Y
G
G
Y
F
R
TWHDKTSDPTEKDKVNSMGELPKEVD
L
A
F
I
F
H
D
WTKDY
S
L
F
W
K
E
L
A
T
K
H
V
P
K
L
N
K
Q
G
T
R
V
I
R
T
I
P
W
R
F
L
A
GGDNSGIAEDTSKYPNT
P
E
G
N
K
A
L
A
K
A
I
V
D
E
YVYKYNLD
G
L
D
V
Q
VEHDS
I
P
K
V
DKKED
T
A
G
V
E
R
S
I
Q
V
F
E
E
I
G
K
L
IGPKGVDKS
R
L
F
I
M
D
S
TYMADKNPLIERGAPYIN
L
L
L
V
Q
VYGSQGEKGGWEPVSNRPEKT
M
E
E
R
W
Q
G
Y
SKYIRPEQ
Y
M
I
G
F
S
F
YEENAQEGNLWYDINSRKDEDKANGINTDITGT
R
A
E
R
Y
A
R
WQPKTGGVKG
G
I
F
S
Y
AIDRDGVAHQPKKYAKKDATDNIFHSDY
S
V
S
K
A
L
K
T
V
M
L
K
DKSYDLIDEKDFPD
K
A
L
R
E
A
V
M
A
Q
VGTR
K
G
D
L
E
RFN
G
T
L
R
LDNPAIQSLEGLN
K
F
K
K
L
A
Q
L
D
L
--------
I
G
L
S
R
I
T
K
L
D
R
S
V
L
P
A
-
N
M
K
P
G
K
D
---
T
L
E
T
V
L
E
T
Y
K
K
D
N
K
-
E
E
P
A
T
I
P
P
---------
V
S
L
----
K
---
V
S
G
L
T
G
----
L
-
K
--
E
L
D
L
S
G
F
-
D
R
E
T
L
A
G
-----------------------------------
L
D
A
A
T
L
T
---
S
L
E
K
V
D
I
S
G
N
K
L
D
L
A
P
-
G
T
E
N
R
Q
I
--
F
----
D
T
M
L
S
---
T
I
S
N
H
V
G
-----
S
N
--
E
--
Q
T
V
K
F
D
K
Q
K
P
T
G
H
Y
P
D
T
Y
G
K
T
S
L
R
L
P
V
A
N
E
K
VDLQSQ
L
L
F
G
T
V
T
NQGTLINS
E
A
D
Y
K
A
Y
Q
N
HKIAGRSFVDSNYHYNNFKVSYEN
Y
T
V
K
V
T
D
STLGTTTDKTLATDKE
E
T
Y
K
V
D
F
F
S
PADKTKAV
H
T
A
K
V
I
V
G
DEKTMMVNLAEG
A
T
V
I
G
GSAD
P
V
N
A
R
K
V
F
DGQLGSETDNISLGWDS
K
Q
S
I
I
F
K
L
KEDGLIK
H
W
R
F
F
N
DSARNPETTNKPIQ
E
A
S
L
Q
I
F
NIKDYN
L
D
N
L
L
E
NPNKFDDEKYWITV
D
T
Y
S
A
QGERAT
A
F
S
N
T
L
N
NITSK
Y
W
R
V
V
F
D
TKGDRYSSPVVP
E
L
Q
I
L
G
Y
PLPN
A
D
T
I
M
K
T
V
T
T
A
K
E
L
S
Q
QKDKFS
Q
K
M
L
D
E
L
K
I
K
E
M
A
L
E
T
S
L
N
SKIFD
V
T
A
I
N
A
N
A
G
V
L
K
D
C
I
EK
63
Fugue
68.41
14%
-28
- C8 -
2VT3
1
REX_BACSU
A:
[11-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
A
K
R
L
P
L
--------
Y
-
Y
R
F
L
K
N
L
-
H
A
S
G
K
Q
-
R
V
S
S
A
E
L
---
S
D
A
V
K
V
D
S
A
T
I
R
R
D
-
F
S
Y
------
F
G
A
L
G
Y
-
N
V
D
Y
----
L
---
L
S
F
F
R
K
----
T
-
L
--
D
Q
D
D
V
I
L
I
G
V
G
N
L
G
T
A
F
L
H
Y
----------
N
T
K
I
S
M
A
F
D
I
--
N
E
SK
I
G
T
E
V
G
G
V
P
V
Y
N
L
D
D
L
E
Q
H
V
K
D
E
S
V
A
I
L
T
V
-
P
--
A
V
A
A
Q
S
I
----
T
D
R
L
V
---
A
L
G
I
K
G
I
-----
L
N
F
T
P
--
A
R
L
N
V
P
-
E
H
I
R
-
I
H
H
I
D
L
A
V
E
L
Q
S
L
V
Y
F
L
K
H
YS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
67.70
15%
-26
- C7 -
2X7M
2
AMZA_METKA
A:
[14-193]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVP
R
G
S
H
M
K
L
C
L
V
A
FDGRIPM
L
-
S
S
I
V
D
R
F
-
E
E
H
V
S
E
-
Y
L
G
E
V
K
V
---
K
K
K
R
A
K
L
P
E
H
A
Y
S
K
-
V
R
G
Q
Y
L
A
R
A
L
L
D
T
L
R
-
G
M
K
G
----
E
---
Y
D
R
V
L
G
----
L
-
T
--
S
E
D
L
Y
A
P
-
G
L
N
F
V
F
--
G
Q
A
R
----------
C
P
G
R
E
A
V
V
S
V
--
A
R
--
L
L
D
P
D
P
E
L
Y
L
E
-
R
V
V
K
E
L
T
H
E
L
G
H
T
---------------
F
----
G
L
G
H
C
PDR
N
C
V
M
S
F
S
-----
S
-------
S
L
L
E
V
-
D
R
K
S
-
P
N
F
C
R
R
C
T
E
L
L
Q
R
N
L
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
67.48
12%
-30
* C7 *
1K8K
-
ARPC4_BOVIN
F:
[2-167]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAT
L
R
P
Y
L
S
A
V
R
A
--------
T
-
L
Q
A
A
L
C
L
-
E
N
F
S
S
Q
--
V
V
E
R
H
N
---
K
P
E
V
E
V
R
S
S
K
E
L
L
L
-
Q
P
--------------
V
T
I
S
----
R
---
N
E
K
E
K
V
----
L
-
I
--
E
G
S
I
N
--------------
S
----------
V
R
V
S
I
A
V
K
Q
A
--
D
E
--
I
E
K
I
L
C
H
K
F
M
R
-
F
M
M
M
R
------
A
E
N
F
F
I
L
-
R
--
R
K
P
V
--
E
----
G
Y
D
------
I
S
F
L
I
T
-----
N
F
H
T
E
Q
M
Y
K
H
K
L
V
-
D
F
V
I
-
H
F
M
E
E
I
D
K
E
I
S
E
M
K
L
S
V
N
A
R
A
R
I
V
A
E
E
F
L
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
66.46
12%
-52
- C8 -
1IGR
1
IGF1R_HUMAN
A:
[300-478]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
C
E
E
E
K
K
T
K
--------
T
-
I
D
-
S
V
T
S
-
A
Q
M
L
Q
G
-
C
T
I
F
K
G
--------
N
L
L
I
N
I
R
R
G
N
-
N
I
A
S
E
L
E
N
F
M
G
L
I
E
V
V
T
G
Y
V
----
K
---
I
R
H
S
H
A
----
L
-
V
--
S
L
S
-
F
L
K
-
N
L
R
L
I
L
G
E
E
Q
L
E
----------
G
N
Y
S
F
Y
V
L
D
N
--
Q
N
--
L
------
Q
Q
L
W
-
D
W
D
H
R
N
L
T
I
K
--
A
G
K
M
Y
F
-
A
--
F
N
P
K
--
L
CV
S
E
I
Y
R
M
E
---
E
V
T
G
T
K
G
-----
R
Q
S
-
K
--
G
D
I
N
T
R
-
N
N
G
E
-
R
A
S
C
E
K
E
Q
K
L
I
S
E
E
D
L
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
60.46
13%
-18
- C5 -
2YVS
-
?
A:
[1-219]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
V
H
A
A
D
Q
Y
L
--------
V
-
A
P
G
E
A
D
L
-
L
E
V
H
A
R
-
L
A
G
T
G
L
F
PPF
P
P
V
E
L
P
G
G
V
G
G
L
V
A
R
G
G
F
A
Q
T
F
F
F
P
A
E
V
L
G
-
L
T
F
R
T
PK
G
R
---
R
V
R
A
G
G
----
V
-
V
VK
N
V
Q
G
Y
D
L
-
V
R
L
F
V
G
S
F
G
L
L
G
RAE
E
V
V
L
R
L
R
P
G
R
A
Q
A
F
L
R
R
--
P
F
--
S
G
S
F
P
R
L
V
P
T
P
-
R
F
L
F
A
L
E
D
E
E
G
P
W
L
Y
A
Y
H
F
G
--
H
P
K
E
--
V
----
E
R
F
R
E
---
A
F
G
G
E
E
A
R
P
LDL
R
P
R
F
P
--
R
G
L
G
L
G
-
E
G
P
L
-
W
D
L
R
F
R
Y
Q
D
G
G
A
S
P
P
P
P
P
A
F
L
R
L
A
R
V
L------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Fugue
58.04
11%
-10
- C7 -
1TUJ
1
?
A:
[1-123]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
Q
D
T
V
--------
V
-
A
K
Y
M
E
Y
L
-
M
P
D
I
M
P
-
C
A
D
E
L
H
I
---
S
E
D
--
I
A
T
N
I
Q
A
A
---
K
N
G
A
D
M
S
Q
L
G
C
L
K
A
-
C
V
M
K
----
R
---
I
E
M
L
K
G
T---
E
-
L
--
Y
V
E
P
V
Y
K
-
M
I
E
V
V
H
A
G
N
A
D
D
----------
I
Q
L
V
K
G
I
A
N
E
C
I
E
N
--
A
K
G
E
T
D
E
C
N
I
G
-
N
K
Y
T
D
C
Y
I
E
K
L
F
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
55.20
37%
-1
- C3 -
4KH3
3
?
A:
[56-122]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
G
G
T
G
R
N
T
T
V
T
A
N
-
G
R
Q
---
I
V
Q
A
G
G
T
A
S
-
D
T
V
I
----
R
DG
G
G
Q
S
L
N
G
----
L
A
V
--
N
T
T
L
D
N
R
-
G
E
Q
W
V
H
G
G
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
54.41
15%
-14
- C6 -
1WIJ
-
EIL3_ARATH
A:
[162-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
V
L
Q
D
L
Q
-----------
D
A
T
L
G
S
L
-
L
S
S
L
M
Q
H
C
D
P
P
Q
R
K
---
Y
P
L
E
K
G
T
P
P
P
W
W
P
T
-
G
N
E
--------------------------------------------------
E
W
W
V
K
L
G
--
L
----------
P
K
S
Q
S
P
P
Y
R
K
--
P
H
--
D
L
K
K
M
W
K
V
G
V
L
-
T
A
V
I
N
H
M
L
P
D
I
A
K
I
K
R
H
V
-
R
--
Q
S
K
C
--
L
----
Q
D
K
M
T
---
A
-----------
K
E
S
A
I
--
W
L
A
V
L
N
-
Q
E
E
----------
S
L
I
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
40.87
13%
-72
- C9 -
3V7B
-
?
A:
[22-65]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
G
F
E
E
C
P
Y
L
D
S
-
Q
W
V
A
----
D
---
T
N
G
Q
R
M
T
G
Q
G
V
-
D
--
T
R
F
-
D
T
P
-
A
C
V
F
W
S
Y
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
30.32
11%
-64
- C9 -
3MK7
-
?
B:
[6-30]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
K
N
V
G
--------
L
-
L
T
L
F
M
I
L
-
A
V
S
I
G
G
-
L
T
Q
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
26.94
12%
76
- C9 -
2KXH
-
FUBP1_HUMAN
B:
[30-46]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
-
K
D
A
L
Q
R
A
R
Q
I
A
A
K
I
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
24.92
27%
135
- C4 -
3WOA
-
MALE_ECOLI (first)
A:
[35-49]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
A
-
D
K
M
G
M
G
-
Q
S
G
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
23.23
64%
211
- C1 -
2VDA
-
LAMB_ECOL6
B:
[6-16]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
R
R
K
L
P
L
--------
A
-
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
20.86
19%
59
* C9 *
2KZQ
-
A:
[1-36]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
----
L
---
P
A
L
S
T
G
----
L
-
L
--
H
L
H
Q
N
I
V
-
D
V
Q
Y
M
Y
G
L
S
P
A
I
----------
T
K
Y
V
V
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
1.00
0%
267
- C2 -
2AP3
-
?
A:
[3-19]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
-
I
Q
R
P
T
S
-
T
T
T
D
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------