@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1346: (2016-04-30 )
MTAGSDLDDFRGLLAKAFDERVVAWTAEAEAQERFPRQLIEHLGVCGVFDAKWATDARPDVGKLVELAFALGQLASAGIGVGVSLHDSAIAILRRFGKSDYLRDICDQAIRGAAVLCIGASEESGGSDLQIVETEIRSRDGGFEVRGVKKFVSLSPIADHIMVVARSVDHDPTSRHGNVAVVAVPAAQVSVQTPYRKVGAGPLDTAAVCIDTWVPADALVARAGTGLAAISWGLAHERMSIAGQIAASCQRAIGITLARMMSRRQFGQTLFEHQALRLRMADLQARVDLLRYALHGIAEQGRLELRTAAAVKVTAARLGEEVISECMHIFGGAGYLVDETTLGKWWRDMKLARVGGGTDEVLWELVAAGMTPDHDGYAAVVGASKA
Atome Classification :
(20 SA)
-----.........10........20........30.....--...40........50...-------..---...60.-------....-...70.....--...--80....--.---..-.-.90......----..100.......110.......120.......130.......-140.......150.......160.....-..170.---......180..--...--.--.190.......200.......210..-......220-.......230.......240.......250.......260.......270.......280.......290......---.---300........310.......320.......330......-.340.......350.......360.......370.......380....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----MTAGS
D
L
D
D
F
R
G
L
L
A
K
A
F
DER
V
V
A
W
TA
E
A
E
A
Q
E
R
F
P
--
R
Q
L
I
E
H
LGVCGVFDAKWA-------TD---ARP
D
V
G
-------
K
L
V
E
-
L
A
F
A
L
G
Q
L
A
S--AGI--
G
-
V
G
V
S
--L---
H
D
-
S
-
A
I
A
I
L
R
R
FG----K
S
D
Y
L
R
D
I
C
D
Q
A
IRG
A
A
V
L
C
I
GASEESGGSD
L
Q
I
V
E
T
E
IRSR-DGG
F
E
V
R
G
V
K
K
F
VSL
S
P
I
A
D
H
I
M
V
V
A
RS-VDHDPT---SRHG
N
V
A
V
V
A
V--PA
A
--
Q
--
V
S
VQTP
Y
R
KVGAGPLD
T
A
A
V
C
I-DTW-V
P
A
D
A
L
V
A
R-AGT
G
L
A
A
I
S
W
G
L
A
H
E
R
M
S
I
A
G
Q
I
A
A
S
C
Q
R
A
I
G
I
T
L
A
R
M
M
S
R
R
Q
F
G
Q
T
L
F
E
H
Q
A
L
R
L
R
M
A
D
L
Q
A
R
V
D
L
L
R
Y
A
L
H
G
I
A
---E---QG-
R
L
E
L
R
T
A
A
A
V
K
V
T
A
A
R
L
G
E
E
V
I
S
E
C
M
H
I
FGGA
G
Y
L
VD-E
T
T
L
G
K
W
W
R
D
M
K
L
A
RVGG
G
T
D
E
V
L
W
E
L
V
A
AGMTPDHDG
Y
A
A
V
VGASKA
1
PsiBlast_PDB
99.21
100%
-126
- C2 -
4XVX
3
MBTN_MYCTU
A:
[8-384]
---------
S
D
L
D
D
F
R
G
L
L
A
K
A
F
D
E
R
V
V
A
W
T
A
E
A
E
A
Q
E
R
F
P
--
R
Q
L
I
E
H
L
G
V
C
G
V
F
D
A
K
W
A
-------
T
D
---
A
R
P
D
V
G
-------
K
L
V
E
-
L
A
F
A
L
G
Q
L
A
S
--
A
G
I
--
G
-
V
G
V
S
--
L
---
H
D
-
S
-
A
I
A
I
L
R
R
F
G
----
K
S
D
Y
L
R
D
I
C
D
Q
A
I
R
G
A
A
V
L
C
I
G
A
S
E
E
S
G
G
S
D
L
Q
I
V
E
T
E
I
R
S
R
-
D
G
G
F
E
V
R
G
V
K
K
F
V
S
L
S
P
I
A
D
H
I
M
V
V
A
R
S
-
V
D
---------
H
G
N
V
A
V
V
A
V
--
P
A
A
--
Q
--
V
S
V
Q
T
P
Y
R
K
V
G
A
G
P
L
D
T
A
A
V
C
I
-
D
T
W
-
V
P
A
D
A
L
V
A
R
-
A
G
T
G
L
A
A
I
S
W
G
L
A
H
E
R
M
S
I
A
G
Q
I
A
A
S
C
Q
R
A
I
G
I
T
L
A
R
M
M
S
R
R
Q
F
G
Q
T
L
F
E
H
Q
A
L
R
L
R
M
A
D
L
Q
A
R
V
D
L
L
R
Y
A
L
H
G
I
A
---
E
---
Q
G
-
R
L
E
L
R
T
A
A
A
V
K
V
T
A
A
R
L
G
E
E
V
I
S
E
C
M
H
I
F
G
G
A
G
Y
L
V
D
-
E
T
T
L
G
K
W
W
R
D
M
K
L
A
R
V
G
G
G
T
D
E
V
L
W
E
L
V
A
A
G
M
T
P
D
H
D
G
Y
A
A
V
V
-----
21
PsiBlast_CBE
98.19
100%
-123
- C2 -
4XVX
3
MBTN_MYCTU
B:
[8-384]
---------
S
D
L
D
D
F
R
G
L
L
A
K
A
F
D
E
R
V
V
A
W
T
A
E
A
E
A
Q
E
R
F
P
--
R
Q
L
I
E
H
L
G
V
C
G
V
F
D
A
K
W
A
-------
T
D
---
A
R
P
D
V
G
-------
K
L
V
E
-
L
A
F
A
L
G
Q
L
A
S
--
A
G
I
--
G
-
V
G
V
S
--
L
---
H
D
-
S
-
A
I
A
I
L
R
R
F
G
----
K
S
D
Y
L
R
D
I
C
D
Q
A
I
R
G
A
A
V
L
C
I
G
A
S
E
E
S
G
G
S
D
L
Q
I
V
E
T
E
I
R
S
R
-
D
G
G
F
E
V
R
G
V
K
K
F
V
S
L
S
P
I
A
D
H
I
M
V
V
A
R
S
-
V
D
H
D
P
-------
G
N
V
A
V
V
A
V
--
P
A
A
--
Q
--
V
S
V
Q
T
P
Y
R
K
V
G
A
G
P
L
D
T
A
A
V
-
I
-
D
T
W
-
V
P
A
D
A
L
V
A
R
-
A
G
T
G
L
A
A
I
S
W
G
L
A
H
E
R
M
S
I
A
G
Q
I
A
A
S
C
Q
R
A
I
G
I
T
L
A
R
M
M
S
R
R
Q
F
G
Q
T
L
F
E
H
Q
A
L
R
L
R
M
A
D
L
Q
A
R
V
D
L
L
R
Y
A
L
H
G
I
A
---
E
---
Q
G
-
R
L
E
L
R
T
A
A
A
V
K
V
T
A
A
R
L
G
E
E
V
I
S
E
C
M
H
I
F
G
G
A
G
Y
L
V
D
-
E
T
T
L
G
K
W
W
R
D
M
K
L
A
R
V
G
G
G
T
D
E
V
L
W
E
L
V
A
A
G
M
T
P
D
H
D
G
Y
A
A
V
V
-----
22
HHSearch
94.13
96%
-121
- C2 -
4XVX
3
MBTN_MYCTU
A:
[8-384]
---------
S
D
L
D
D
F
R
G
L
L
A
K
A
F
D
E
R
V
V
A
W
T
A
E
A
E
A
Q
E
R
F
P
--
R
Q
L
I
E
H
L
G
V
C
G
V
F
D
A
K
W
A
TDARPD
V
G
K
---
L
V
E
L
A
F
-------
A
L
G
Q
-
L
-------
A
S
--
A
G
I
--
G
-
V
G
V
S
--
L
---
H
D
-
S
-
A
I
A
I
L
R
R
F
G
----
K
S
D
Y
L
R
D
I
C
D
Q
A
I
R
G
A
A
V
L
C
I
G
A
S
E
E
S
G
G
S
D
L
Q
I
V
E
T
E
I
R
S
R
-
D
G
G
F
E
V
R
G
V
K
K
F
V
S
L
S
P
I
A
D
H
I
M
V
V
A
R
S
----
V
D
------
H
G
N
V
A
V
V
A
V
--
P
A
A
--
Q
--
V
S
V
Q
T
P
Y
R
K
V
G
A
G
P
L
D
T
A
A
V
C
I
-
D
T
W
-
V
P
A
D
A
L
V
A
R
-
A
G
T
G
L
A
A
I
S
W
G
L
A
H
E
R
M
S
I
A
G
Q
I
A
A
S
C
Q
R
A
I
G
I
T
L
A
R
M
M
S
R
R
Q
F
G
Q
T
L
F
E
H
Q
A
L
R
L
R
M
A
D
L
Q
A
R
V
D
L
L
R
Y
A
L
H
G
I
A
---
E
---
Q
G
-
R
L
E
L
R
T
A
A
A
V
K
V
T
A
A
R
L
G
E
E
V
I
S
E
C
M
H
I
F
G
G
A
G
Y
L
-
V
D
E
T
T
L
G
K
W
W
R
D
M
K
L
A
R
V
G
G
G
T
D
E
V
L
W
E
L
V
A
A
G
M
T
P
D
H
D
G
Y
A
A
V
V
-----
42
Fugue
63.81
22%
-105
- C2 -
1IVH
5
IVD_HUMAN
A:
[6-392]
VDDAI
N
G
L
S
E
E
Q
R
Q
L
R
Q
T
M
A
K
F
L
Q
E
H
L
A
P
K
A
Q
E
I
D
R
S
N
E
F
K
N
L
R
E
F
W
K
Q
L
G
N
L
G
V
L
G
I
T
A
P
-------
V
Q
YGG
S
G
---
L
-------
G
Y
L
E
-
H
V
L
V
M
E
E
I
S
R
A
S
G
A
V
--
G
-
L
S
Y
G
--
A
---
H
S
-
N
L
C
I
N
Q
L
V
R
N
G
----
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
G
E
Y
I
G
A
L
A
M
S
E
P
N
A
G
S
D
V
V
S
M
K
L
K
A
E
K
K
G-
N
H
Y
I
L
N
G
N
K
F
W
I
T
N
G
P
D
A
D
V
L
I
V
Y
A
K
T
-
D
L
A
A
V
----
P
A
S
R
G
I
T
A
F
I
V
--
E
K
G
--
M
PG
F
S
T
S
K
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
I
F
E
D
C
K
-
I
P
A
A
N
I
L
G
H
-
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
K
A
C
D
---
E
G
-
H
C
T
A
K
D
C
A
G
V
I
L
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
-
I
N
-
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
V
R
R
L
V
I
G
R
A
F
N
A
D
-------------
37
HHSearch
62.12
23%
-100
- C2 -
4KTO
4
?
A:
[34-408]
--------
G
E
E
I
D
A
L
R
A
S
V
R
R
F
A
S
E
R
I
A
P
L
A
D
D
A
D
R
S
N
A
F
P
--
M
S
L
W
R
E
M
G
E
L
G
L
L
G
I
T
A
D
EAHGGAG
L
G
---
Y
L
A
H
C
V
-------
A
M
E
E
-
I
-------
S
R
--
A
S
A
S
V
G
-
L
S
Y
G
--
A
---
H
S
N
L
-
C
V
N
Q
I
N
R
N
G
----
K
P
A
Q
K
S
R
Y
L
P
K
L
I
S
G
E
H
V
G
A
L
A
M
S
E
P
G
-----
V
S
M
K
L
K
A
D
K
R
-
G
D
R
Y
V
L
N
G
S
K
M
W
I
T
N
G
P
D
A
D
V
L
V
V
Y
A
K
T
----
D
P
------
P
R
G
I
T
A
F
L
V
--
E
K
A
FP
G
--
F
S
A
G
Q
K
L
D
K
L
G
M
R
G
S
N
T
S
E
L
I
F
T
D
C
E
-
V
P
E
E
N
V
L
G
G
-
V
G
E
G
V
K
V
L
M
S
G
L
D
Y
E
R
V
V
L
S
A
G
P
L
G
I
M
A
A
C
L
D
V
V
V
P
Y
L
H
E
R
K
Q
F
G
Q
P
I
G
E
F
Q
L
M
Q
G
K
L
A
D
M
Y
V
T
M
N
A
A
R
A
Y
V
Y
A
V
A
A
A
C
D
---
R
G
-
E
T
A
R
K
D
A
A
G
C
I
L
Y
A
A
E
K
A
T
A
M
A
L
E
A
I
Q
A
L
G
G
N
G
Y
T
-
N
-
D
Y
P
A
G
R
L
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
I
R
R
M
L
I
G
R
E
L
F
A
E
-------------
33
HHSearch
61.56
23%
-98
- C2 -
1IVH
5
IVD_HUMAN
A:
[13-392]
-------
L
S
E
E
Q
R
Q
L
R
Q
T
M
A
K
F
L
Q
E
H
L
A
P
K
A
Q
E
I
D
R
S
N
E
F
K
N
L
R
E
F
W
K
Q
L
G
N
L
G
V
L
G
I
T
A
P
VQYGGSG
L
G
---
Y
L
E
H
V
L
-------
V
M
E
E
-
I
-------
S
R
--
A
S
G
A
V
G
-
L
S
Y
G
--
A
---
H
S
N
L
-
C
I
N
Q
L
V
R
N
G
----
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
G
E
Y
I
G
A
L
A
M
S
E
P
N
A
G
S
D
V
V
S
M
K
L
K
A
E
K
K
-
G
N
H
Y
I
L
N
G
N
K
F
W
I
T
N
G
P
D
A
D
V
L
I
V
Y
A
K
T
----
D
L
A
AV-
P
A
S
R
G
I
T
A
F
I
V
--
E
K
G
MP
G
--
F
S
T
S
K
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
I
F
E
D
C
K
-
I
P
A
A
N
I
L
G
H
-
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
K
A
C
D
---
E
G
-
H
C
T
A
K
D
C
A
G
V
I
L
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
I
-
N
-
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
V
R
R
L
V
I
G
R
A
F
N
A
D
-------------
30
HHSearch
61.27
19%
-95
- C2 -
3SWO
5
?
A:
[25-397]
------
L
L
D
Q
D
E
R
D
I
A
A
T
V
R
Q
F
V
D
T
R
L
K
P
N
V
E
G
W
F
E
S
A
T
L
P
--
S
E
L
A
K
E
F
G
N
L
G
V
L
G
M
H
L
Q
GYGCAG-
T
N
---
A
V
S
Y
G
L
-------
A
C
M
E
-
L
-------
E
A
--
G
D
S
G
F
R
-
S
F
V
S
--
V
---
Q
G
S
L
-
S
M
F
S
I
Y
R
Y
G
----
S
E
E
Q
K
N
E
W
L
P
R
L
A
A
G
D
A
I
G
C
F
G
L
T
E
P
D
F
G
S
N
P
A
G
M
R
T
R
A
R
R
D
-
G
S
D
W
I
L
N
G
T
K
M
W
I
T
N
G
N
L
A
D
V
A
T
V
W
A
Q
T
----
D
D
--------
G
I
R
G
F
L
V
--
P
T
D
TP
G
--
F
T
A
N
E
I
H
R
K
L
S
L
R
A
S
V
T
S
E
L
V
L
D
N
V
R
-
L
P
A
S
A
Q
L
P
L
--
A
E
G
L
S
A
P
L
S
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
S
L
E
T
T
I
A
Y
T
Q
S
R
E
V
F
D
K
P
L
S
N
Y
Q
L
T
Q
E
K
L
A
N
M
T
V
E
L
G
K
G
M
L
L
A
I
H
L
G
R
I
K
D
---
A
E
-
G
V
R
P
E
Q
I
S
L
G
K
L
N
N
V
R
E
A
I
A
I
A
R
E
C
R
T
L
L
G
G
S
G
I
T
-
L
-
E
Y
S
P
L
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
L
L
S
I
G
K
A
L
T
G
K
A
A
F
----------
8
PsiBlast_PDB
60.71
23%
-102
- C2 -
1IVH
5
IVD_HUMAN
A:
[20-380]
--------------
L
R
Q
T
M
A
K
F
L
Q
E
H
L
A
P
K
A
Q
E
I
D
R
S
N
E
F
K
N
L
R
E
F
W
K
Q
L
G
N
L
G
V
L
G
I
T
A
P
-------
V
Q
---
Y
G
G
S
G
L
-------
G
Y
L
E
-
H
V
L
V
M
E
E
I
S
R
--
A
S
G
--
A
-
V
G
L
S
--
Y
G
A
H
S
N
-
L
-
C
I
N
Q
L
V
R
N
G
----
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
G
E
Y
I
G
A
L
A
M
S
E
P
N
A
G
S
D
V
V
S
M
K
L
K
A
E
K
K
-
G
N
H
Y
I
L
N
G
N
K
F
W
I
T
N
G
P
D
A
D
V
L
I
V
Y
A
K
T
D
L
A
A
V
P
A
---
S
R
G
I
T
A
F
I
V
E
K
--
G
M
P
--
G
--
F
S
T
S
K
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
I
F
E
D
C
K
-
I
P
A
A
N
I
L
G
H
-
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
K
A
C
D
---
E
G
-
H
C
T
A
K
D
C
A
G
V
I
L
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
-
I
N
-
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
V
-------------------------
38
HHSearch
59.92
20%
-100
- C2 -
2JIF
9
ACDSB_HUMAN
A:
[29-403]
-------
F
T
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
S
K
M
E
--
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
PEYGGTG
A
S
---
F
L
S
T
V
L
-------
V
I
E
E
-
L
-------
A
K
--
V
D
A
S
V
A
-
V
F
C
E
--
I
---
Q
N
T
L
-
I
N
T
L
I
R
K
H
G
----
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
E
-
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
D
K
E
-
G
D
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
----
D
P
T
---
I
G
Y
K
G
I
T
S
F
L
V
--
D
R
D
TP
G
--
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
-
V
P
E
A
N
I
L
G
Q
-
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
---
A
G
-
K
P
F
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
-
K
-
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
D
A
E
-------------
36
HHSearch
59.89
23%
-99
- C2 -
2PG0
2
?
A:
[10-383]
-------
L
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
G
I
I
P
--
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
EKYGGLN
A
D
---
F
A
Y
S
V
V
-------
I
N
E
E
-
L
-------
E
K
--
V
G
S
--
S
L
V
G
I
G
--
L
---
H
N
D
I
-
V
T
P
Y
I
A
S
Y
G
----
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
D
-
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
----
D
P
Q
AK-
P
P
H
R
G
I
S
L
L
V
V
--
E
R
D
TP
G
--
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
-
V
P
A
Y
N
L
L
G
E
-
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
H
M
---
A
G
-
K
Q
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
-
E
-
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
----------------
13
PsiBlast_PDB
59.82
27%
-106
- C2 -
1WS9
-
?
A:
[39-380]
---------------------------------------
F
P
--
W
D
L
V
R
K
L
A
E
F
G
V
F
G
A
-
L
V
-------
P
E
---
A
Y
G
G
A
G
LS
T
R
L
F
A
R
M
V
E
A
I
A
Y
Y
D
G
A
L
A
----------
L
T
V
A
--
S
---
H
N
-
S
L
A
T
G
H
I
L
L
A
G
----
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
V
-
E
G
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
P
P
P
S
P
E
---
R
K
H
Q
G
I
S
A
F
A
F
F
R
P
E
R
--
G
--
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
-
V
P
E
E
A
L
L
G
E
-
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
---
E
L
K
D
A
G
-
R
P
F
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
--
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
-------------------
35
HHSearch
59.80
22%
-94
- C2 -
4IV6
2
?
A:
[7-385]
-------
L
T
A
E
E
E
T
I
V
K
T
V
H
D
F
V
E
K
Q
V
K
P
V
V
R
E
L
E
H
A
N
T
Y
P
--
E
E
L
I
E
T
M
K
E
I
G
I
F
G
L
A
I
P
EPYGFGA
V
S
---
M
P
C
Y
V
Q
-------
V
A
E
E
-
L
-------
A
R
--
G
W
M
S
L
A
-
G
A
M
G
--
G
---
H
T
-
V
-
V
S
K
L
L
L
L
F
G
----
T
E
E
Q
K
Q
K
Y
L
P
R
M
A
T
G
E
L
R
A
T
M
A
L
T
E
P
G
G
G
S
D
L
Q
A
M
R
T
V
A
R
R
D
-
G
D
D
Y
V
I
N
G
S
K
T
W
I
S
N
A
R
R
S
D
L
V
A
L
M
C
K
T
----
D
P
D
AQ-
P
A
H
K
G
V
S
I
L
L
V
--
E
K
V
P-
G
--
F
D
V
S
R
D
L
P
K
L
G
Y
K
G
V
E
S
C
E
L
N
F
T
D
A
R
-
V
P
V
S
S
L
L
G
D
D
E
G
R
G
F
A
Q
M
M
K
G
L
E
V
G
R
L
Q
V
A
A
R
A
T
G
V
A
R
A
A
F
E
D
A
L
R
Y
S
Q
E
R
E
S
F
G
K
P
I
W
Q
H
Q
S
V
G
N
M
L
A
D
M
G
T
K
L
Y
A
A
R
S
L
L
L
S
A
A
E
K
F
D
---
A
G
-
Q
R
C
D
M
E
A
G
M
A
K
L
F
A
S
E
T
A
M
Q
I
A
L
D
A
V
R
V
H
G
G
Y
G
Y
S
-
T
-
E
Y
D
V
E
R
Y
F
R
D
A
P
L
M
I
V
G
E
G
T
N
E
I
Q
R
N
V
I
A
K
Q
L
V
A
R
G
G
-----------
4
PsiBlast_PDB
59.65
26%
-101
- C2 -
4M9A
1
?
A:
[21-382]
-----------
L
D
A
A
R
A
F
C
A
E
V
L
A
P
N
A
A
Q
W
D
R
E
S
----
H
L
P
--
D
E
V
V
A
Q
M
G
E
L
G
F
L
G
M
I
V
P
-------
A
D
---
W
G
G
S
Y
T
-------
D
Y
V
A
-
Y
A
L
A
L
E
E
I
A
A
G
C
A
S
C
--
A
-
T
L
V
S
--
V
---
H
N
-
S
V
G
C
G
P
V
L
N
Y
G
T
T
E
Q
K
E
R
W
L
R
D
L
A
S
G
K
T
V
G
A
F
S
L
----
T
E
P
H
-----
H
N
L
R
T
R
A
E
L
R
-
D
G
K
W
I
L
N
G
S
K
Q
F
V
T
N
G
A
R
A
G
L
A
I
V
F
A
M
T
--
D
P
D
E
G
---
K
R
G
L
S
A
F
V
V
P
T
--
D
T
P
--
G
--
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
L
-
E
N
C
A
I
P
Q
E
N
L
L
G
K
-
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
T
G
I
A
R
A
A
F
D
R
A
R
R
Y
A
R
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
A
E
K
L
A
N
M
A
T
Q
I
N
A
A
R
L
L
T
H
H
A
A
---
R
L
R
T
A
G
-
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
A
V
C
S
D
A
I
Q
I
H
G
G
Y
G
F
L
V
D
--
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
-------------------
31
HHSearch
59.23
17%
-92
- C2 -
2IX5
5
ACOX4_ARATH
A:
[55-429]
-------
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
E
K
A
E
F
P
--
F
H
I
T
P
K
L
G
A
M
G
V
A
G
G
S
I
K
GYGCPG-
L
S
---
I
T
A
N
A
I
-------
A
T
A
E
-
I
-------
A
R
--
V
D
A
S
C
S
-
T
F
I
L
--
V
---
H
S
S
L
-
G
M
L
T
I
A
L
C
G
----
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
A
S
G
L
G
T
T
A
T
K
V
-
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
A
D
L
L
I
I
F
A
R
N
----
T
T
------
T
N
Q
I
N
G
F
I
V
--
K
K
D
AP
G
--
L
K
A
T
K
I
P
N
K
I
G
L
R
M
V
Q
N
G
D
I
L
L
Q
N
V
F
-
V
P
D
E
D
R
L
P
G
-
V
N
-
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
---
T
G
-
Q
M
T
P
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
-
A
-
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
F
K
---------
29
HHSearch
59.17
24%
-103
- C2 -
3NF4
1
?
A:
[15-386]
------
L
P
S
Q
E
A
A
E
L
I
E
L
T
R
E
I
A
D
K
V
L
D
P
I
V
D
R
H
E
K
D
E
T
Y
P
--
E
G
V
F
E
Q
L
G
A
A
G
L
L
S
L
P
Q
P
EEWGGGG
Q
P
---
Y
E
V
Y
L
Q
-------
V
L
E
E
-
I
-------
A
A
--
R
W
A
S
V
A
-
V
A
V
S
--
V
---
H
S
-
L
-
S
S
H
P
L
L
V
F
G
----
T
E
E
Q
K
K
R
W
L
P
G
M
L
S
G
E
Q
I
G
A
Y
S
L
S
E
P
Q
A
G
S
D
A
A
A
L
R
C
A
A
T
P
T
-
D
G
G
Y
V
I
N
G
S
K
S
W
I
T
H
G
G
K
A
D
F
Y
T
L
F
A
R
T
----
G
-------
S
R
G
V
S
C
F
L
V
--
P
A
D
QP
G
--
L
S
F
G
K
P
E
E
K
M
G
L
H
A
V
P
T
T
S
A
F
Y
D
N
A
R
-
I
D
A
D
R
R
I
G
E
-
E
G
Q
G
L
Q
I
A
F
S
A
L
D
S
G
R
L
G
I
A
A
V
A
T
G
L
A
Q
A
A
L
D
E
A
V
A
Y
A
N
E
------
K
I
I
D
H
-
G
L
G
F
L
L
A
D
M
A
A
A
V
A
T
A
R
A
T
Y
L
D
A
A
R
R
R
D
---
Q
G
-
R
P
Y
S
Q
Q
A
S
I
A
K
L
T
A
T
D
A
A
M
K
V
T
T
D
A
V
Q
V
F
G
G
V
G
Y
T
-
R
-
D
Y
R
V
E
R
Y
M
R
E
A
K
I
M
Q
I
F
E
G
T
N
Q
I
Q
R
L
V
I
A
R
G
L
T
---------------
15
PsiBlast_PDB
59.11
27%
-104
- C2 -
2D29
2
?
A:
[39-380]
---------------------------------------
F
P
--
W
D
L
V
R
K
L
A
E
F
G
V
F
G
A
-
L
V
-------
P
E
---
A
Y
G
G
A
G
LS
T
R
L
F
A
R
M
V
E
A
I
A
Y
Y
D
G
A
L
A
----------
L
T
V
A
--
S
---
H
N
-
S
L
A
T
G
H
I
L
L
A
G
----
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
V
-
E
G
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
P
P
P
S
P
E
---
R
K
H
Q
G
I
S
A
F
A
F
F
R
P
E
R
--
G
--
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
-
V
P
E
E
A
L
L
G
E
-
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
---
E
L
K
D
A
G
-
R
P
F
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
--
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
-------------------
41
HHSearch
58.95
24%
-99
- C2 -
3R7K
5
?
A:
[30-402]
--------
T
P
E
R
R
A
L
S
Q
M
A
R
S
F
V
E
R
E
I
A
P
K
L
A
E
W
E
H
V
G
E
I
P
--
R
D
L
H
L
N
A
A
E
V
G
L
L
G
I
G
F
P
EEVGGSG
G
N
---
A
I
D
S
A
L
-------
V
T
E
A
-
I
-------
L
A
--
A
G
G
S
T
G
-
V
C
A
A
L
F
T
---
H
G
-
I
-
A
L
P
H
I
A
A
N
G
----
S
D
A
L
I
E
R
Y
V
R
P
T
L
A
G
K
M
I
G
S
L
G
V
T
E
P
G
A
G
S
D
V
A
N
L
R
T
R
A
V
R
E
-
G
D
T
Y
V
V
N
G
A
K
T
F
I
T
S
G
V
R
A
D
F
V
T
T
A
V
R
T
----
G
G
P
----
G
Y
G
G
V
S
L
L
V
I
--
D
K
N
SP
G
--
F
E
V
S
R
R
L
D
K
M
G
W
R
C
S
D
T
A
E
L
S
F
V
D
V
R
-
V
P
A
D
N
L
V
G
A
-
E
N
S
G
F
L
Q
I
M
Q
Q
F
Q
A
E
R
L
G
I
A
V
Q
A
Y
A
T
A
G
R
A
L
D
L
A
K
S
W
A
R
E
R
E
T
F
G
R
P
L
T
G
R
Q
I
I
R
H
K
L
A
E
M
A
R
Q
V
D
V
A
C
T
Y
T
R
A
V
M
Q
R
W
L
---
A
G
-
E
D
V
V
A
E
V
S
M
A
K
N
T
A
V
Y
A
C
D
Y
V
V
N
E
A
V
Q
I
F
G
G
M
G
Y
M
-
R
-
E
S
E
I
E
R
H
Y
R
D
C
R
I
L
G
I
G
G
G
T
N
E
I
M
N
E
V
I
A
K
R
I
G
---------------
14
PsiBlast_PDB
58.93
27%
-104
- C2 -
2CX9
-
?
A:
[39-380]
---------------------------------------
F
P
--
W
D
L
V
R
K
L
A
E
F
G
V
F
G
A
-
L
V
-------
P
E
---
A
Y
G
G
A
G
LS
T
R
L
F
A
R
M
V
E
A
I
A
Y
Y
D
G
A
L
A
----------
L
T
V
A
--
S
---
H
N
-
S
L
A
T
G
H
I
L
L
A
G
----
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
V
-
E
G
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
P
P
P
S
P
E
---
R
K
H
Q
G
I
S
A
F
A
F
F
R
P
E
R
--
G
--
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
-
V
P
E
E
A
L
L
G
E
-
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
---
E
L
K
D
A
G
-
R
P
F
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
--
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
-------------------
25
HHSearch
58.82
20%
-100
- C2 -
1RX0
8
ACAD8_HUMAN
A:
[19-392]
-------
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
K
E
L
F
P
--
V
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
TDVGGSG
L
S
---
R
L
D
T
S
V
-------
I
F
E
A
-
L
-------
A
T
--
G
C
T
S
T
T
-
A
Y
I
S
--
I
---
H
N
-
M
-
C
A
W
M
I
D
S
F
G
----
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
K
K
Q
-
G
D
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
----
G
G
----
P
G
P
K
G
I
S
C
I
V
V
--
E
K
G
TP
G
--
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
-
V
P
V
A
N
R
I
G
S
-
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
V
A
L
Q
---
E
E
R
K
D
A
V
A
L
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
-
K
-
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
L
Q
--------------
34
HHSearch
58.75
20%
-92
- C2 -
4P13
3
ACADM_HUMAN
A:
[7-386]
-------
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
K
T
G
E
Y
P
--
V
P
L
I
R
R
A
W
E
L
G
L
M
N
T
H
I
P
ENCGGLG
L
G
---
T
F
D
A
C
L
-------
I
S
E
E
-
L
-------
A
Y
--
G
C
T
G
V
Q
-
T
A
I
E
--
G
---
N
S
-
L
-
G
Q
M
P
I
I
I
A
G
----
N
D
Q
Q
K
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
-
G
D
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
----
D
P
D
PKA
P
A
N
K
A
F
T
G
F
I
V
--
E
A
D
TP
G
--
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
-
V
P
K
E
N
V
L
I
G
-
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
E
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
---
S
G
-
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
-
T
-
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
Y
K
-----------