@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1692: (2016-05-04 )
MKSIAQEHDCLLIDLDGTVFCGRQPTGGAVQSLSQVRSRKLFVTNNASRSADEVAAHLCELGFTATGEDVVTSAQSAAHLLAGQLAPGARVLIVGTEALANEVAAVGLRPVRRFEDRPDAVVQGLSMTTGWSDLAEAALAIRAGALWVAANVDPTLPTERGLLPGNGSMVAALRTATGMDPRVAGKPAPALMTEAVARGDFRAALVVGDRLDTDIEGANAAGLPSLMVLTGVNSAWDAVYAEPVRRPTYIGHDLRSLHQDSKLLAVAPQPGWQIDVGGGAVTVCANGDVDDLEFIDDGLSIVRAVASAVWEARAADLHQRPLRIEAGDERARAALQRWSLMRSDHPVTSVGTQ
Atome Classification :
(23 SA)
.........10........20.--......-.---30---......---.---.40---........50........60.....-...70....-....80....-----.--...90........100.......110..------..---------------...--120----.........130.......140-.-......150.......160........170.......180.-.......190-.....--....200.--..----......210.......220.......230..--.....240.......250.......260.......270.......280......-.290.......300.......310.......320.......330.......340.......350.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKSIAQEH
D
C
L
L
I
DLDG
T
V
F
CG--RQPT
G
G
-
A
---
V
Q
---
S
L
S
Q
V
R---S---
R
K
L
---
F
V
TNNASR
S
A
D
E
V
A
A
H
L
C
ELGFTAT-
G
E
D
V
V
T
S
A
Q
-
S
A
A
H
L
L
A
GQL-----A--PG
A
R
V
L
I
V
G
T
E
A
L
A
N
E
V
A
A
VG
L
R
P
V
R
R
F------ED---------------R
P
D
--
A
------
V
V
QGLSMTT
G
W
S
D
L
A
E
A
A
L
A
IR-A-
G
A
L
W
V
AANVDPTLPTERG-LLPGNG
S
M
V
A
A
L
RTATGMDP-R-VAGKP
A
P
A
---
L
M
T
E
A
--
V
ARGD--
F
--
R
A
----
A
L
V
VGDRLDTDIEGANAAGL
P
S
L
M
V
L
TGV
N
S
--
A
W
D
A
V
Y
AEPVRRPTYI
G
H
D
L
R
S
L
HQDS
K
L
L
A
VAPQPG
W
Q
I
DVGG
G
A
V
T
V
CANGD-V
D
D
L
E
F
I
D
D
G
L
S
I
V
R
A
V
A
S
A
V
W
E
A
R
A
A
DLHQR
P
L
R
IEAG
D
E
R
A
R
A
A
L
Q
R
W
S
L
M
RSDHPVTSVGTQ
1
PsiBlast_PDB
98.26
100%
-110
- C2 -
4I9F
2
?
A:
[10-352]
-
K
S
I
A
Q
E
H
D
C
L
L
I
D
L
D
G
T
V
F
C
G
--
R
Q
P
T
G
G
-
A
---
V
Q
---
S
L
S
Q
V
R
---
S
---
R
K
L
---
F
V
T
N
N
A
S
R
S
A
D
E
V
A
A
H
L
C
E
L
G
F
T
A
T
-
G
E
D
V
V
T
S
A
Q
-
S
A
A
H
L
L
A
G
Q
L
-----
A
--
P
G
A
R
V
L
I
V
G
T
E
A
L
A
N
E
V
A
A
V
G
L
R
P
V
R
R
F
------
E
D
---------------
R
P
D
--
A
------
V
V
Q
G
L
S
M
T
T
G
W
S
D
L
A
E
A
A
L
A
I
R
-
A
-
G
A
L
W
V
A
A
N
V
D
P
T
L
P
T
E
R
G
-
L
L
P
G
N
G
S
M
V
A
A
L
R
T
A
T
G
M
D
P
-
R
-
V
A
G
K
P
A
P
A
---
L
M
T
E
A
--
V
A
R
G
D
--
F
--
R
A
----
A
L
V
V
G
D
R
L
D
T
D
I
E
G
A
N
A
A
G
L
P
S
L
M
V
L
T
G
V
N
S
--
A
W
D
A
V
Y
A
E
P
V
R
R
P
T
Y
I
G
H
D
L
R
S
L
H
Q
D
S
K
L
L
A
V
A
P
Q
P
G
W
Q
I
D
V
G
G
G
A
V
T
V
C
A
N
G
--------
I
D
D
G
L
S
I
V
R
A
V
A
S
A
V
W
E
A
R
A
A
D
L
H
Q
R
P
L
R
I
E
A
G
D
E
R
A
R
A
A
L
Q
R
W
S
L
M
R
S
D
---------
56
Fugue
97.99
99%
-109
- C2 -
4I9F
2
?
A:
[10-352]
-
K
S
I
A
Q
E
H
D
C
L
L
I
D
L
D
G
T
V
F
C
G
--
R
Q
P
T
G
G
-
A
---
V
Q
---
S
L
S
Q
V
R
---
S
---
R
K
L
---
F
V
T
N
N
A
S
R
S
A
D
E
V
A
A
H
L
C
E
L
G
F
T
A
T
-
G
E
D
V
V
T
S
A
Q
-
S
A
A
H
L
L
A
G
Q
L
-----
A
--
P
G
A
R
V
L
I
V
G
T
E
A
L
A
N
E
V
A
A
V
G
L
R
P
V
R
R
F
------
E
D
---------------
R
P
D
--
A
------
V
V
Q
G
L
S
M
T
T
G
W
S
D
L
A
E
A
A
L
A
I
R
-
A
-
G
A
L
W
V
A
A
N
V
D
P
T
L
P
T
E
R
G
-
L
L
P
G
N
G
S
M
V
A
A
L
R
T
A
T
G
M
D
P
-
R
-
V
A
G
K
P
A
P
A
---
L
M
T
E
A
--
V
A
R
G
D
--
F
--
R
A
----
A
L
V
V
G
D
R
L
D
T
D
I
E
G
A
N
A
A
G
L
P
S
L
M
V
L
T
G
V
N
S
--
A
W
D
A
V
Y
A
E
P
V
R
R
P
T
Y
I
G
H
D
L
R
S
L
H
Q
D
S
K
L
L
A
V
A
P
Q
P
G
W
Q
I
D
V
G
G
G
A
V
T
V
C
A
N
G
I
--------
D
D
G
L
S
I
V
R
A
V
A
S
A
V
W
E
A
R
A
A
D
L
H
Q
R
P
L
R
I
E
A
G
D
E
R
A
R
A
A
L
Q
R
W
S
L
M
R
S
D
---------
22
PsiBlast_CBE
96.98
100%
-112
- C2 -
4I9F
2
?
B:
[9-360]
M
K
S
I
A
Q
E
H
D
C
L
L
I
D
L
D
G
T
V
F
C
G
--
R
Q
P
T
G
G
-
A
---
V
Q
---
S
L
S
Q
V
R
---
S
---
R
K
L
---
F
V
T
N
N
A
S
R
S
A
D
E
V
A
A
H
L
C
E
L
G
F
T
A
T
-
G
E
D
V
V
T
S
A
Q
-
S
A
A
H
L
L
A
G
Q
L
-----
A
--
P
G
A
R
V
L
I
V
G
T
E
A
L
A
N
E
V
A
A
V
G
L
R
P
V
R
R
F
------
E
D
---------------
R
P
D
--
A
------
V
V
Q
G
L
S
M
T
T
G
W
S
D
L
A
E
A
A
L
A
I
R
-
A
-
G
A
L
W
V
A
A
N
V
D
P
T
L
P
T
E
R
G
-
L
L
P
G
N
G
S
M
V
A
A
L
R
T
A
T
G
M
D
P
-
R
-
V
A
G
K
P
A
P
A
---
L
M
T
E
A
--
V
A
R
G
D
--
F
--
R
A
----
A
L
V
V
G
D
R
L
D
T
D
I
E
G
A
N
A
A
G
L
P
S
L
M
V
L
T
G
V
N
S
--
A
W
D
A
V
Y
A
E
P
V
R
R
P
T
Y
I
G
H
D
L
R
S
L
H
Q
D
S
K
L
L
A
V
A
P
Q
P
G
W
Q
I
D
V
G
G
G
A
V
T
V
C
A
N
G
D
-
V
D
D
L
E
F
I
D
D
G
L
S
I
V
R
A
V
A
S
A
V
W
E
A
-------
R
P
L
R
I
E
A
G
D
E
R
A
R
A
A
L
Q
R
W
S
L
M
R
S
D
H
P
V
T
S
V
G
T
-
21
PsiBlast_CBE
96.32
100%
-113
- C2 -
4I9G
1
?
B:
[9-349]
M
K
S
I
A
Q
E
H
D
C
L
L
I
D
L
D
G
T
V
F
C
G
--
R
Q
P
T
G
G
-
A
---
V
Q
---
S
L
S
Q
V
R
---
S
---
R
K
L
---
F
V
T
N
N
A
S
R
S
A
D
E
V
A
A
H
L
C
E
L
G
F
T
A
T
-
G
E
D
V
V
T
S
A
Q
-
S
A
A
H
L
L
A
G
Q
L
-----
A
--
P
G
A
R
V
L
I
V
G
T
E
A
L
A
N
E
V
A
A
V
G
L
R
P
V
R
R
F
------
E
D
---------------
R
P
D
--
A
------
V
V
Q
G
L
S
M
T
T
G
W
S
D
L
A
E
A
A
L
A
I
R
-
A
-
G
A
L
W
V
A
A
N
V
D
P
T
L
P
T
E
R
G
-
L
L
P
G
N
G
S
M
V
A
A
L
R
T
A
T
G
M
D
P
-
R
-
V
A
G
K
P
A
P
A
---
L
M
T
E
A
--
V
A
R
G
D
--
F
--
R
A
----
A
L
V
V
G
D
R
L
D
T
D
I
E
G
A
N
A
A
G
L
P
S
L
M
V
L
T
G
V
N
S
--
A
W
D
A
V
Y
A
E
P
V
R
R
P
T
Y
I
G
H
D
L
R
S
L
H
Q
D
S
K
L
L
A
V
A
P
Q
P
G
W
Q
I
D
V
G
G
G
A
V
T
V
C
A
N
----------
D
D
G
L
S
I
V
R
A
V
A
S
A
V
W
E
A
------
Q
R
P
L
R
I
E
A
G
D
E
R
A
R
A
A
L
Q
R
W
S
L
M
------------
36
HHSearch
96.10
98%
-108
- C2 -
4I9F
2
?
A:
[11-352]
--
S
I
A
Q
E
H
D
C
L
L
I
D
L
D
G
T
V
F
C
G
--
R
Q
P
T
G
G
-
A
---
V
Q
---
S
L
S
Q
V
R
---
S
---
R
K
L
---
F
V
T
N
N
A
S
R
S
A
D
E
V
A
A
H
L
C
E
L
G
F
T
A
T
-
G
E
D
V
V
T
S
A
Q
-
S
A
A
H
L
L
A
G
Q
L
-----
A
--
P
G
A
R
V
L
I
V
G
T
E
A
L
A
N
E
V
A
A
V
G
L
R
P
V
R
R
F
------
E
D
---------------
R
P
D
--
A
------
V
V
Q
G
L
S
M
T
T
G
W
S
D
L
A
E
A
A
L
A
I
R
-
A
-
G
A
L
W
V
A
A
N
V
D
P
T
L
P
T
E
R
G
-
L
L
P
G
N
G
S
M
V
A
A
L
R
T
A
T
G
M
D
P
-
R
-
V
A
G
K
P
A
P
A
---
L
M
T
E
A
--
V
A
R
G
D
--
F
--
R
A
----
A
L
V
V
G
D
R
L
D
T
D
I
E
G
A
N
A
A
G
L
P
S
L
M
V
L
T
G
V
N
S
--
A
W
D
A
V
Y
A
E
P
V
R
R
P
T
Y
I
G
H
D
L
R
S
L
H
Q
D
S
K
L
L
A
V
A
P
Q
P
G
W
Q
I
D
V
G
G
G
--
A
V
T
V
C
A
N
G------
I
D
D
G
L
S
I
V
R
A
V
A
S
A
V
W
E
A
R
A
A
D
L
H
Q
R
P
L
R
I
E
A
G
D
E
R
A
R
A
A
L
Q
R
W
S
L
M
R
S
D
---------
43
HHSearch
61.71
29%
-80
- C2 -
1VJR
3
?
A:
[12-269]
--
H
V
L
D
K
I
E
L
F
I
L
D
M
D
G
T
F
Y
L
D
--
D
S
L
L
P
G
-
S
---
L
E
---
F
L
E
T
L
K
---
E
K
N
K
R
F
V
---
F
F
T
N
N
S
S
L
G
A
Q
D
Y
V
R
K
L
R
N
M
G
V
D
V
P
-
D
D
A
V
V
T
S
G
E
-
I
T
A
E
H
M
L
K
R
F
--------
G
R
C
R
I
F
L
L
G
T
P
Q
L
K
K
V
F
E
A
Y
G
H
V
I
D
---------
E
E
---------------
N
P
D
--
F
------
V
V
L
G
F
D
K
T
L
T
Y
E
R
L
K
K
A
C
I
L
L
R
-
K
-
G
K
F
Y
I
A
T
H
P
D
I
N
C
P
S
K
E
G
-
P
V
P
D
A
G
S
I
M
A
A
I
E
A
S
T
G
R
K
P
D
L
-
I
A
G
K
P
N
P
L
---
V
V
D
V
I
--
S
E
K
F
G
VP
K
--
E
R
----
M
A
M
V
G
D
R
L
Y
T
D
V
K
L
G
K
N
A
G
I
V
S
I
L
V
L
T
G
E
T
T
--
P
E
D
L
E
--
R
A
E
T
K
P
D
F
V
F
K
N
L
G
E
L
A
K
A
----------------------------------------------------------------------------------------------
18
PsiBlast_PDB
61.34
34%
-88
- C2 -
4BX0
2
?
A:
[12-263]
L
R
D
V
L
G
Q
A
Q
G
V
L
F
D
C
D
G
V
L
W
N
G
--
E
R
I
V
P
G
-
A
P
E
L
L
Q
---
R
L
A
R
A
G
---
K
---
N
T
L
---
F
V
S
N
N
S
R
R
A
R
P
E
L
A
L
R
F
A
R
L
G
F
A
G
L
R
A
E
Q
L
F
S
S
A
L
-
C
A
A
R
L
L
R
Q
R
L
SGP-----
S
G
A
-
V
F
V
L
G
G
E
G
L
R
A
E
L
R
A
A
G
L
R
L
A
G
D
P
------
G
E
---------------
D
P
R
VR
A
------
V
L
V
G
Y
D
E
Q
F
S
F
S
R
L
T
E
A
C
A
H
L
R
D
P
-
D
C
L
L
V
A
T
D
R
D
P
W
H
P
L
S
D
G
S
R
T
P
G
T
G
S
L
A
K
K
V
E
T
A
S
G
R
Q
A
-
L
-
V
V
G
K
P
S
P
----
Y
M
F
Q
C
--
I
T
E
-
D
--
F
--
S
V
DPAR
T
L
M
V
G
D
R
L
E
T
D
I
L
F
G
H
R
C
G
M
T
T
V
L
T
L
T
G
V
S
S
--
L
E
E
A
--------------------------------------------------------------------------------------------------------------------
39
HHSearch
60.58
30%
-70
- C2 -
1ZJJ
1
?
A:
[1-261]
-------
M
V
A
I
I
F
D
M
D
G
V
L
Y
R
G
--
N
R
A
I
P
G
-
V
---
R
E
---
L
I
E
F
L
K
---
E
R
G
I
P
F
A
---
F
L
T
N
N
S
T
K
T
P
E
M
Y
R
E
K
L
L
K
M
G
I
D
V
S
-
S
S
I
I
I
T
S
G
L
-
A
T
R
L
Y
M
S
K
H
L
--------
D
P
G
K
I
F
V
I
G
G
E
G
L
V
K
E
M
Q
A
L
G
W
G
I
V
T
L
D
E
A
R
Q
GS
W
K
---------------
E
V
K
--
H
------
V
V
V
G
L
D
P
D
L
T
Y
E
K
L
K
Y
A
T
L
A
I
R
-
N
-
G
A
T
F
I
G
T
N
P
D
A
T
L
P
G
E
E
G
-
I
Y
P
G
A
G
S
I
I
A
A
L
K
V
A
T
N
V
E
P
-
I
-
I
I
G
K
P
N
E
P
---
M
Y
E
V
V
--
R
E
M
F
P
--
G
--
E
E
----
L
W
M
V
G
D
R
L
D
T
D
I
A
F
A
K
K
F
G
M
K
A
I
M
V
L
T
G
V
S
S
--
L
E
D
I
K
--
K
S
E
Y
K
P
D
L
V
L
P
S
V
Y
E
L
I
D
Y
L
K
--------------------------------------------------------------------------------------------
14
PsiBlast_PDB
60.58
27%
-81
- C2 -
4JDP
5
?
A:
[23-281]
---
M
M
P
D
K
K
G
Y
I
I
D
I
D
G
V
I
G
K
S
--
V
T
P
I
P
E
-
G
---
V
E
---
G
V
K
K
L
K
E
L
G
K
---
K
I
I
---
F
V
S
N
N
S
T
R
S
R
R
I
L
L
E
R
L
R
S
F
G
L
E
V
G
-
E
D
E
I
L
V
A
T
Y
-
A
T
A
R
F
I
A
R
E
------
K
--
P
N
A
K
V
F
T
T
G
E
E
G
L
I
E
E
L
R
L
A
G
L
E
I
V
D
Y
--------
D
---------------
E
A
E
--
Y
------
L
V
V
G
S
N
R
K
I
N
F
E
L
M
T
K
A
L
R
A
C
L
-
R
-
G
I
R
Y
I
A
T
N
P
D
R
I
F
P
A
E
D
G
-
P
I
P
G
T
G
M
I
I
G
A
L
Y
W
M
T
G
R
E
P
-
D
V
V
V
G
K
P
S
E
V
---
I
M
R
E
A
L
D
I
L
G
L
D
--
A
--
K
D
----
V
A
V
V
G
D
Q
I
D
V
D
V
A
A
G
K
A
I
G
A
E
T
V
L
V
L
T
G
V
T
T
RE
N
L
D
Q
M
I
E
R
H
G
L
K
P
D
Y
V
F
N
S
L
K
D
M
-------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.00
32%
-88
- C2 -
3EPR
2
?
A:
[5-246]
-------
Y
K
G
Y
L
I
D
L
D
G
T
I
Y
K
G
KS
R
I
P
A
G
E
R
F
---
I
E
---
R
L
Q
E
K
G
---
I
---
P
Y
M
---
L
V
T
N
N
T
T
R
T
P
E
S
V
Q
E
M
L
R
G
F
N
V
E
T
P
-
L
E
T
I
Y
T
A
T
M
-
A
T
V
D
Y
M
-
N
D
M
-----
N
--
R
G
K
T
A
Y
V
I
G
E
E
G
L
K
K
A
I
A
D
A
G
Y
-----
V
------
E
D
TK-------------
N
P
A
--
Y
------
V
V
V
G
L
D
W
N
V
T
Y
D
K
L
A
T
A
T
L
A
I
Q
-
N
-
G
A
L
F
I
G
T
N
P
D
L
N
I
P
T
E
R
G
-
L
L
P
G
A
G
S
L
N
A
L
L
E
A
A
T
R
I
K
P
-
V
-
F
I
G
K
P
N
A
I
---
I
M
N
K
A
--
L
E
I
L
N
--
I
PR
N
Q
----
A
V
M
V
G
D
N
Y
L
T
D
I
M
A
G
I
N
N
D
I
D
T
L
L
V
T
T
G
F
T
T
--
V
-
E
E
V
P
D
L
P
I
-
Q
P
S
Y
V
--------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
59.70
31%
-84
- C2 -
4BKM
3
PGP_MOUSE (first)
A:
[16-280]
L
R
D
V
L
G
Q
A
Q
G
V
L
F
D
C
D
G
V
L
W
N
G
--
E
R
I
V
P
G
-
A
P
E
L
L
Q
---
R
L
A
R
A
G
---
K
---
N
T
L
---
F
V
S
N
N
S
R
R
A
R
P
E
L
A
L
R
F
A
R
L
G
F
A
G
L
R
A
E
Q
L
F
S
S
A
L
-
C
A
A
R
L
L
R
Q
R
L
-----
A
GV
P
D
P
K
A
Y
V
L
G
S
P
A
L
A
A
E
L
E
A
V
G
V
T
S
V
G
V
G
------
P
D
V
L
H
G
DG
P
S
D
W
L
A
VPL
E
P
D
VR
A
------
V
V
V
G
F
D
P
H
F
S
Y
M
K
L
T
K
A
V
R
Y
L
Q
-
Q
P
D
C
L
L
V
G
T
N
M
D
N
R
L
P
L
E
N
G
R
F
I
A
G
T
G
C
L
V
R
A
V
E
M
A
A
Q
R
Q
A
-
D
-
I
I
G
K
P
S
P
----
Y
M
F
Q
C
--
I
T
E
-
D
--
F
--
S
V
DPAR
T
L
M
V
G
D
R
L
E
T
D
I
L
F
G
H
R
C
G
M
T
T
V
L
T
L
T
G
V
S
S
--
L
E
E
A
--------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
59.61
31%
-82
- C2 -
4BKM
2
PGP_MOUSE (first)
B:
[16-280]
L
R
D
V
L
G
Q
A
Q
G
V
L
F
D
C
D
G
V
L
W
N
G
--
E
R
I
V
P
G
-
A
PEL
L
Q
---
R
L
A
R
A
G
---
K
---
N
T
L
---
F
V
S
N
N
S
R
R
A
R
P
E
L
A
L
R
F
A
R
L
G
F
A
G
L
R
A
E
Q
L
F
S
S
A
L
-
C
A
A
R
L
L
R
Q
R
L
-----
A
GV
P
D
P
K
A
Y
V
L
G
S
P
A
L
A
A
E
L
E
A
V
G
V
T
S
V
G
V
G
------
P
D
VLHGDGPSDWLAVPL
E
P
D
VR
A
------
V
V
V
G
F
D
P
H
F
S
Y
M
K
L
T
K
A
V
R
Y
L
Q
-
Q
P
D
C
L
L
V
G
T
N
M
D
N
R
L
P
L
E
N
G
R
F
I
A
G
T
G
C
L
V
R
A
V
E
M
A
A
Q
R
Q
A
-
D
-
I
I
G
K
P
S
P
----
Y
M
F
Q
C
--
I
T
E
-
D
--
F
--
S
V
DPAR
T
L
M
V
G
D
R
L
E
T
D
I
L
F
G
H
R
C
G
M
T
T
V
L
T
L
T
G
V
S
S
--
L
E
E
A
--------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
59.33
30%
-84
- C2 -
1VJR
-
?
A:
[18-266]
--------
E
L
F
I
L
D
M
D
G
T
F
Y
L
D
--
D
S
L
L
P
G
-
S
---
L
E
F
L
E
T
L
K
E
K
N
---
K
---
R
F
V
---
F
F
T
N
N
S
S
L
G
A
Q
D
Y
V
R
K
L
R
N
M
G
V
D
V
P
-
D
D
A
V
V
T
S
G
E
I
T
A
E
H
M
L
--
K
R
-----
F
--
G
R
C
R
I
F
L
L
G
T
P
Q
L
K
K
V
F
E
A
Y
G
H
V
I
D
---------
E
E
---------------
N
P
D
--
F
------
V
V
L
G
F
D
K
T
L
T
Y
E
R
L
K
K
A
C
I
L
L
R
-
K
-
G
K
F
Y
I
A
T
H
P
D
I
N
C
P
S
K
E
G
-
P
V
P
D
A
G
S
I
M
A
A
I
E
A
S
T
G
R
K
P
-
D
L
I
A
G
K
P
N
P
L
V
V
D
V
I
S
E
K
--
F
G
V
P
K
--
E
--
R
M
----
A
-
M
V
G
D
R
L
Y
T
D
V
K
L
G
K
N
A
G
I
V
S
I
L
V
L
T
G
E
T
T
--
P
E
D
L
E
R
A
E
--
T
K
P
D
F
V
F
K
N
L
G
E
L
-------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
59.21
31%
-83
- C2 -
4BKM
1
PGP_MOUSE (first)
D:
[16-280]
L
R
D
V
L
G
Q
A
Q
G
V
L
F
D
C
D
G
V
L
W
N
G
--
E
R
I
V
P
G
-
A
PEL
L
Q
---
R
L
A
R
A
G
---
K
---
N
T
L
---
F
V
S
N
N
S
R
R
A
R
P
E
L
A
L
R
F
A
R
L
G
F
A
G
L
R
A
E
Q
L
F
S
S
A
L
-
C
A
A
R
L
L
R
Q
R
L
-----
A
GV
P
D
P
K
A
Y
V
L
G
S
P
A
L
A
A
E
L
E
A
V
G
V
T
S
V
G
V
G
------
P
D
VLHGDGPSDWLAVPL
E
P
D
VR
A
------
V
V
V
G
F
D
P
H
F
S
Y
M
K
L
T
K
A
V
R
Y
L
Q
-
Q
P
D
C
L
L
V
G
T
N
M
D
N
R
L
P
L
E
N
G
R
F
I
A
G
T
G
C
L
V
R
A
V
E
M
A
A
Q
R
Q
A
-
D
-
I
I
G
K
P
S
P
----
Y
M
F
Q
C
--
I
T
E
-
D
--
F
--
S
V
DPAR
T
L
M
V
G
D
R
L
E
T
D
I
L
F
G
H
R
C
G
M
T
T
V
L
T
L
T
G
V
S
S
--
L
E
E
A
--------------------------------------------------------------------------------------------------------------------
46
HHSearch
59.19
33%
-78
- C2 -
4KN8
-
?
A:
[1-254]
----
M
R
K
Y
N
G
Y
L
I
D
L
D
G
T
M
Y
R
G
--
T
E
R
I
D
A
-
A
---
S
G
---
F
I
K
E
L
N
---
R
L
H
I
P
Y
L
---
F
V
T
N
N
S
T
R
T
P
E
Q
V
A
D
K
L
V
S
L
D
I
P
A
T
-
P
E
Q
I
F
T
S
S
M
-
A
T
A
N
Y
V
Y
D
L
D
--------
Q
N
A
M
I
Y
F
I
G
E
E
G
L
Y
K
A
L
K
E
K
G
F
S
F
A
---------
D
E
---------------
N
A
D
--
V
------
V
I
V
G
L
D
R
E
V
T
Y
E
K
L
A
V
A
C
L
A
V
R
-
N
-
G
A
K
L
I
S
T
N
G
D
L
A
L
P
T
E
R
G
-
F
M
P
G
N
G
A
F
T
A
L
I
S
H
S
T
Q
V
K
A
-
T
-
F
V
G
K
P
E
P
I
---
I
M
E
Q
A
--
L
K
V
L
G
TN
K
--
N
E
----
T
I
M
V
G
D
N
Y
D
T
D
I
L
A
G
I
R
A
G
L
D
T
L
L
V
H
T
G
V
T
T
--
V
E
K
L
K
--
E
Y
K
Q
Q
P
T
Y
S
M
K
S
L
D
D
W
K
F
-----------------------------------------------------------------------------------------------
28
PsiBlast_CBE
59.17
34%
-84
- C2 -
4BX2
3
?
B:
[13-264]
L
R
D
V
L
G
Q
A
Q
G
V
L
F
D
C
D
G
V
L
W
N
G
--
E
R
I
V
P
G
-
A
P
E
L
L
Q
---
R
L
A
R
A
G
---
K
---
N
T
L
---
F
V
S
N
N
S
R
R
A
R
P
E
L
A
L
R
F
A
R
L
G
F
A
G
L
R
A
E
Q
L
F
S
S
A
L
-
C
A
A
R
L
L
R
Q
R
L
PGPPD
A
--
S
G
A
-
V
F
V
L
G
G
E
G
L
R
A
E
L
R
A
A
G
L
R
L
A
G
D
P
------
G
E
---------------
D
P
R
VR
A
------
V
L
V
G
Y
D
E
Q
F
S
F
S
R
L
T
E
A
C
A
H
L
R
D
P
-
D
C
L
L
V
A
T
D
R
D
P
W
H
P
L
S
D
G
S
R
T
P
G
T
G
S
L
A
A
A
V
E
T
A
S
G
R
Q
A
-
L
-
V
V
G
K
P
S
P
----
Y
M
F
Q
C
--
I
T
E
-
D
--
F
--
S
V
DPAR
T
L
M
V
G
D
R
L
E
T
D
I
L
F
G
H
R
C
G
M
T
T
V
L
T
L
T
G
V
S
S
--
L
E
E
A
--------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
58.72
31%
-82
- C2 -
4BKM
1
PGP_MOUSE (first)
C:
[16-280]
L
R
D
V
L
G
Q
A
Q
G
V
L
F
D
C
D
G
V
L
W
N
G
--
E
R
I
V
P
G
-
A
PEL
L
Q
---
R
L
A
R
A
G
---
K
---
N
T
L
---
F
V
S
N
N
S
R
R
A
R
P
E
L
A
L
R
F
A
R
L
G
F
A
G
L
R
A
E
Q
L
F
S
S
A
L
-
C
A
A
R
L
L
R
Q
R
L
-----
A
GV
P
D
P
K
A
Y
V
L
G
S
P
A
L
A
A
E
L
E
A
V
G
V
T
S
V
G
V
G
------
P
D
VLHGDGPSDWLAVPL
E
P
D
VR
A
------
V
V
V
G
F
D
P
H
F
S
Y
M
K
L
T
K
A
V
R
Y
L
Q
-
Q
P
D
C
L
L
V
G
T
N
M
D
N
R
L
P
L
E
N
G
R
F
I
A
G
T
G
C
L
V
R
A
V
E
M
A
A
Q
R
Q
A
-
D
-
I
I
G
K
P
S
P
----
Y
M
F
Q
C
--
I
T
E
-
D
--
F
--
S
V
DPAR
T
L
M
V
G
D
R
L
E
T
D
I
L
F
G
H
R
C
G
M
T
T
V
L
T
L
T
G
V
S
S
--
L
E
E
A
--------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
58.55
33%
-82
- C2 -
1ZJJ
1
?
B:
[3-243]
---------
A
I
I
F
D
M
D
G
V
L
Y
R
G
--
N
R
A
I
P
G
-
V
---
R
E
---
L
I
E
F
L
K
---
E
---
R
G
I
PFA
F
L
T
N
N
S
T
K
T
P
E
M
Y
R
E
K
L
L
K
M
G
I
D
V
S
-
S
S
I
I
I
T
S
G
L
-
A
T
R
L
Y
M
S
K
H
L
-----
D
--
P
G
-
K
I
F
V
I
G
G
E
G
L
V
K
E
M
Q
A
L
G
W
G
I
V
T
L
D
------
E
A
---------------
R
Q
G
--
S
WKEVKH
V
V
V
G
L
D
P
D
L
T
Y
E
K
L
K
Y
A
T
L
A
I
R
-
N
-
G
A
T
F
I
G
T
N
P
D
A
T
L
P
G
E
E
G
-
I
Y
P
G
A
G
S
I
I
A
A
L
K
V
A
T
N
V
E
P
-
I
-
I
I
G
K
P
N
E
P
---
M
Y
--
E
--
V
V
R
E
M
--
F
PG
E
E
----
L
W
M
V
G
D
R
L
D
T
D
I
A
F
A
K
K
F
G
M
K
A
I
M
V
L
T
G
V
S
S
--
L
E
D
I
K
K
S
E
----------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
58.49
34%
-85
- C2 -
4BX2
4
PLPP_MOUSE
A:
[13-264]
L
R
D
V
L
G
Q
A
Q
G
V
L
F
D
C
D
G
V
L
W
N
G
--
E
R
I
V
P
G
-
A
P
E
L
L
Q
---
R
L
A
R
A
G
---
K
---
N
T
L
---
F
V
S
N
N
S
R
R
A
R
P
E
L
A
L
R
F
A
R
L
G
F
A
G
L
R
A
E
Q
L
F
S
S
A
L
-
C
A
A
R
L
L
R
Q
R
L
PGPPD
A
--
S
G
A
-
V
F
V
L
G
G
E
G
L
R
A
E
L
R
A
A
G
L
R
L
A
G
D
P
------
G
E
---------------
D
P
R
VR
A
------
V
L
V
G
Y
D
E
Q
F
S
F
S
R
L
T
E
A
C
A
H
L
R
D
P
-
D
C
L
L
V
A
T
D
R
D
P
W
H
P
L
S
D
G
S
R
T
P
G
T
G
S
L
A
A
A
V
E
T
A
S
G
R
Q
A
-
L
-
V
V
G
K
P
S
P
----
Y
M
F
Q
C
--
I
T
E
-
D
--
F
--
S
V
DPAR
T
L
M
V
G
D
R
L
E
T
D
I
L
F
G
H
R
C
G
M
T
T
V
L
T
L
T
G
V
S
S
--
L
E
E
A
--------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
58.40
34%
-84
- C2 -
4BX3
2
PLPP_MOUSE
A:
[13-264]
L
R
D
V
L
G
Q
A
Q
G
V
L
F
D
C
D
G
V
L
W
N
G
--
E
R
I
V
P
G
-
A
P
E
L
L
Q
---
R
L
A
R
A
G
---
K
---
N
T
L
---
F
V
S
N
N
S
R
R
A
R
P
E
L
A
L
R
F
A
R
L
G
F
A
G
L
R
A
E
Q
L
F
S
S
A
L
-
C
A
A
R
L
L
R
Q
R
L
PGPPD
A
--
S
G
A
-
V
F
V
L
G
G
E
G
L
R
A
E
L
R
A
A
G
L
R
L
A
G
D
P
------
G
E
---------------
D
P
R
VR
A
------
V
L
V
G
Y
D
E
Q
F
S
F
S
R
L
T
E
A
C
A
H
L
R
D
P
-
D
C
L
L
V
A
T
D
R
D
P
W
H
P
L
S
D
G
S
R
T
P
G
T
G
S
L
A
A
A
V
E
T
A
S
G
R
Q
A
-
L
-
V
V
G
K
P
S
P
----
Y
M
F
Q
C
--
I
T
E
-
D
--
F
--
S
V
DPAR
T
L
M
V
G
D
R
L
E
T
D
I
L
F
G
H
R
C
G
M
T
T
V
L
T
L
T
G
V
S
S
--
L
E
E
A
--------------------------------------------------------------------------------------------------------------------
38
HHSearch
58.12
34%
-83
- C2 -
3PDW
3
YUTF_BACSU
A:
[2-258]
---
S
L
K
T
Y
K
G
Y
L
I
D
L
D
G
T
M
Y
N
G
--
T
E
K
I
E
E
-
A
---
C
E
---
F
V
R
T
L
K
---
D
R
G
V
P
Y
L
---
F
V
T
N
N
S
S
R
T
P
K
Q
V
A
D
K
L
V
S
F
D
I
P
A
T
-
E
E
Q
V
F
T
T
S
M
-
A
T
A
Q
H
I
A
Q
Q
K
--------
K
D
A
S
V
Y
V
I
G
E
E
G
I
R
Q
A
I
E
E
N
G
L
T
F
G
---------
G
E
---------------
N
A
D
--
F
------
V
V
V
G
I
D
R
S
I
T
Y
E
K
F
A
V
G
C
L
A
I
R
-
N
-
G
A
R
F
I
S
T
N
G
D
I
A
I
P
T
E
R
G
-
L
L
P
G
N
G
S
L
T
S
V
L
T
V
S
T
G
V
Q
P
-
V
-
F
I
G
K
P
E
S
I
---
I
M
E
Q
A
--
M
R
V
L
G
TD
V
--
S
E
----
T
L
M
V
G
D
N
Y
A
T
D
I
M
A
G
I
N
A
G
M
D
T
L
L
V
H
T
G
--------
M
T
D
--
D
M
E
K
P
T
H
A
I
D
S
L
T
E
W
I
P
Y
I
---------------------------------------------------------------------------------------------
17
PsiBlast_PDB
57.89
34%
-84
- C2 -
5AES
2
PLPP_MOUSE
A:
[13-264]
L
R
D
V
L
G
Q
A
Q
G
V
L
F
D
C
D
G
V
L
W
N
G
--
E
R
I
V
P
G
-
A
P
E
L
L
Q
---
R
L
A
R
A
G
---
K
---
N
T
L
---
F
V
S
N
N
S
R
R
A
R
P
E
L
A
L
R
F
A
R
L
G
F
A
G
L
R
A
E
Q
L
F
S
S
A
L
-
C
A
A
R
L
L
R
Q
R
L
PGPPD
A
--
S
G
A
-
V
F
V
L
G
G
E
G
L
R
A
E
L
R
A
A
G
L
R
L
A
G
D
P
------
G
E
---------------
D
P
R
VR
A
------
V
L
V
G
Y
D
E
Q
F
S
F
S
R
L
T
E
A
C
A
H
L
R
D
P
-
D
C
L
L
V
A
T
D
R
D
P
W
H
P
L
S
D
G
S
R
T
P
G
T
G
S
L
A
A
A
V
E
T
A
S
G
R
Q
A
-
L
-
V
V
G
K
P
S
P
----
Y
M
F
Q
C
--
I
T
E
-
D
--
F
--
S
V
DPAR
T
L
M
V
G
D
R
L
E
T
D
I
L
F
G
H
R
C
G
M
T
T
V
L
T
L
T
G
V
S
S
--
L
E
E
A
--------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
57.54
34%
-81
- C2 -
5AES
3
PLPP_MOUSE
B:
[13-264]
L
R
D
V
L
G
Q
A
Q
G
V
L
F
D
C
D
G
V
L
W
N
G
--
E
R
I
V
P
G
-
A
P
E
L
L
Q
---
R
L
A
R
A
G
---
K
---
N
T
L
---
F
V
S
N
N
S
R
R
A
R
P
E
L
A
L
R
F
A
R
L
G
F
A
G
L
R
A
E
Q
L
F
S
S
A
L
-
C
A
A
R
L
L
R
Q
R
L
PGPPD
A
--
S
G
A
-
V
F
V
L
G
G
E
G
L
R
A
E
L
R
A
A
G
L
R
L
A
G
D
P
------
G
E
---------------
D
P
R
VR
A
------
V
L
V
G
Y
D
E
Q
F
S
F
S
R
L
T
E
A
C
A
H
L
R
D
P
-
D
C
L
L
V
A
T
D
R
D
P
W
H
P
L
S
D
G
S
R
T
P
G
T
G
S
L
A
A
A
V
E
T
A
S
G
R
Q
A
-
L
-
V
V
G
K
P
S
P
----
Y
M
F
Q
C
--
I
T
E
-
D
--
F
--
S
V
DPAR
T
L
M
V
G
D
R
L
E
T
D
I
L
F
G
H
R
C
G
M
T
T
V
L
T
L
T
G
V
S
S
--
L
E
E
A
--------------------------------------------------------------------------------------------------------------------