@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1843c: (2016-05-05 )
MMRFLDGHPPGYDLTYNDVFIVPNRSEVASRFDVDLSTADGSGTTIPVVVANMTAVAGRRMAETVARRGGIVILPQDLPIPAVKQTVAFVKSRDLVLDTPVTLAPDDSVSDAMALIHKRAHGVAVVILEGRPIGLVRESSCLGVDRFTRVRDIAVTDYVTAPAGTEPRKIFDLLEHAPVDVAVLTDADGTLAGVLSRTGAIRAGIYTPATDSAGRLRIGAAVGINGDVGAKARALAEAGVDVLVIDTAHGHQVKTLDAIKAVSALDLGLPLAAGNVVSAEGTRDLLKAGANVVKVGVGPGAMCTTRMMTGVGRPQFSAVLECASAARQLGGHIWADGGIRHPRDVALALAAGASNVMIGSWFAGTYESPGDLMRDRDDQPYKESYGMASKRAVVARTGADNPFDRARKALFEEGISTSRMGLDPDRGGVEDLIDHITSGVRSTCTYVGASNLAELHERAVVGVQSGAGFAEGHPLPAGW
Atome Classification :
(42 SA)
.......-..10........20........-30-.--.....--.--.---------40.........50........60........70.......-.80..---...-...-90.-....-....100.......110......-.120...---..--..--.130.......140....-..-.150..----------..---.------.------.160.......170.......180.......190.......200......--.-210-.-.......220.......230.--......240.......250.......260.....-..270.--......280.......290.......300.......310.......320......------.330.......340.......350.......360.......370.--........380--.......390.......400--------...--.....410.......420.......430.......440.......450.......-----460.......470.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MMRFLDG-HPPGYD
L
T
YN
D
V
F
I
VP
N
R
S
E
V
A
-
S
R-F--
D
V
D
L
S--T--A---------D-GSG
T
T
I
P
V
V
V
AN
M
T
A
V
A
G
R
R
M
A
E
T
V
A
RRG
G
I
V
I
LPQDL-P
I
P
A
V
---
K
Q
T
-
V
A
F
-
V
-K-SR
D
L
-
V
LDTPVTLAPDD
S
V
S
D
A
M
A
L
I
H
K-RA-H
G
V
A
---
V
V
--
I
L--EGRPI
G
L
V
RESSCLGV
D
R
-
F
T
-
R
V
R
D
I
A
----------
V
T
---
D
------
Y
------VTAPAGT
E
P
R
K
I
F
D
L
L
E
HAPV
D
V
A
V
L
TDAD
G
T
L
A
G
V
L
SRTG
A
I
R
A
G
I
YTP--A-T-D-S-AG
R
L
R
I
G
A
A
VGINGDVG
A
K
A
R
--
A
L
A
EAGV
D
V
L
V
I
DTAHG
H
Q
V
K
T
L
D
A
I
K
A
V
S
A
LDL-GLPLAA--G
N
V
VSAE
G
T
R
D
L
L
K
AGA
N
V
V
K
VGVGP
G
A
M
C
T
T
R
M
M
TGVG
R
P
Q
F
S
A
V
L
E
C
A
S
A
A
R
Q
------LG
G
H
I
WADGGIRHP
R
D
V
A
L
A
L
AAGASN
V
M
I
G
S
W
FAGTYES
P
G
--
D
--
L
MRDRDDQ
P
Y
K
--
E
SYGMAS
K
R
A
V
V
A
RTGADN---------
P
F
D
--
R
A
R
K
A
L
F
E
EGISTSRMGLDPDRG
G
V
E
D
L
I
D
H
I
T
S
G
V
R
S
T
C
T
YVG
A
S
N
L
A
E
L
H
E
R
A
-----
V
V
G
VQSGAGFAEGHPLPAGW
2
PsiBlast_PDB
94.95
38%
-90
- C1 -
3TSB
2
?
A:
[35-497]
--------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
----
E
V
S
V
K
--
T
VL
S
---------
E
-
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
-
S
I
E
Q
Q
---
A
E
Q
-
V
D
K
-
V
-
K
R
S
E
S
G
-
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
-
S
G
V
P
---
V
V
NN
L
D
--
E
R
K
L
V
G
I
I
T
N
R
D
M
----
R
-
F
I
-
Q
D
Y
S
I
K
----------
I
S
---
D
V
M
T
K
E
Q
L
------
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
-
I
K
D
I
E
K
V
I
E
F
P
N
S
A
-
K
-
D
-
K
-
Q
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
--
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
--
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
--
I
Y
Q
G
R
Q
F
K
V
Y
R
-----
G
M
G
S
V
G
A
-
M
E
K
G
S
K
D
R
---------
Y
F
Q
--
E
G
N
K
K
L
V
P
E
G
I
E
----
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
-----
118
HHSearch
93.65
35%
-92
- C1 -
1ZFJ
1
IMDH_STRPY
A:
[7-482]
---------
F
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
-
P
--
N
--
E
V
D
L
K
--
T
--
K
LA-------
D
-
N
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
-
S
I
T
E
Q
---
A
E
E
-
V
R
K
-
V
K
R
-
S
E
N
G
-
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
-
Y
R
I
S
G
V
P
---
I
V
--
E
T
LA
N
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
S
D
Y
N
A
-
P
I
S
E
H
M
----------
T
S
E--
H
------
L
------
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
H
--
A
A
K
-
D
-
E
-
F
G
R
L
L
V
A
A
A
V
G
V
T
S
D
T
F
E
R
A
E
--
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
-
N
R
T
L
I
A
--
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
------
Y
G
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
--
E
--
T
E
I
-
Y
Q
G
R
K
Y
K
--
T
Y
R
G
M
G
S
I
A
A
M
K
K
-----------------------
N
K
L
V
P
E
G
I
E
G
----
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
N
A
-----
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
3
PsiBlast_PDB
93.30
38%
-101
- C1 -
3TSD
1
?
A:
[35-497]
--------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
----
E
V
S
V
K
--
T
VL
S
---------
E
-
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
-
S
I
E
Q
Q
---
A
E
Q
-
V
D
K
-
V
-
K
R
S
E
S
G
-
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
-
S
G
V
P
---
V
V
NN
L
D
--
E
R
K
L
V
G
I
I
T
N
R
D
M
----
R
-
F
I
-
Q
D
Y
S
I
K
----------
I
S
---
D
VMK
E
Q
-
L
------
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
-
I
K
D
I
E
K
V
I
E
F
P
N
S
A
-
K
-
D
-
K
-
Q
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
--
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
--
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E--------
R
Q
F
K
V
Y
R
-----
G
----------------------------------------
E
----
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
-----
4
PsiBlast_PDB
92.71
36%
-108
- C1 -
3USB
4
?
A:
[35-493]
--------------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
----
E
V
S
V
K
--
T
VL
S
---------
E
-
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
-
S
I
E
Q
Q
---
A
E
Q
-
V
D
K
-
V
-
K
R
S
E
S
G
-
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
-
S
G
V
P
---
V
V
NN
L
D
--
E
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
-
Y
S
I
K
I
S
D
V
M
----------
T
K
---
E
Q
-----
L
------
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
-
I
K
D
I
E
K
V
I
E
F
P
N
S
A
-
K
-
D
-
K
-
Q
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
--
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
--
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
--
I
Y
Q
G
R
Q
F
K
V
-------------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
---------
117
HHSearch
92.16
36%
-103
- C1 -
3USB
4
?
A:
[29-493]
--------
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
----
E
V
S
V
K
--
T
--
V
LS-------
E
-
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
-
S
I
E
Q
Q
---
A
E
Q
-
V
D
K
V
K
-
R
-
S
E
S
G
-
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
-
Y
R
I
S
G
V
P
---
V
V
--
N
N
LD
E
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
Y
S
I
-
K
I
S
D
V
M
----------
T
K
E
--
Q
------
L
------
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
--
S
-
A
-
K
D
K
-
Q
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
--
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
--
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
--
E
--
T
E
I
-
Y
Q
G
R
Q
F
K
--
V
--------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
---------
121
HHSearch
91.48
34%
-96
- C1 -
4FXS
3
?
A:
[6-479]
---------
I
A
K
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
-
P
N
-
T
AD
L
R
T
R
L
--
T
--
K
---------
N
-
I
A
L
-
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
-
S
I
E
Q
Q
---
A
A
Q
-
V
H
Q
-
V
-
K
-
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
T
H
Y
-
H
G
F
A
G
F
P
---
V
V
--
T
E
--
N
N
E
L
V
G
I
I
T
G
R
D
V
R
F
V
T
D
L
T
K
-
S
V
A
A
V
M
----------
T
P
KE-
R
------
L
------
A
T
V
K
E
G
----
E
V
Q
E
K
M
H
---
V
E
K
I
L
V
V
N
D
E
F
Q
L
K
G
M
I
T
A
K
-----
E
S
K
P
N
--
A
-
C
K
D
-
E
-
Q
G
R
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
R
G
M
G
S
L
G
A
M
S
K
G
-
S
S
D
R
---------
Y
F
Q
T---
A
D
K
L
V
P
E
G
I
E
G
----
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
5
PsiBlast_PDB
90.57
35%
-89
- C1 -
1ZFJ
1
IMDH_STRPY
A:
[6-477]
--
K
F
L
----
K
K
G
Y
--
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
-
P
N
----
E
V
D
L
K
--
T
KL
A
---------
D
-
N
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
-
S
I
T
E
Q
---
A
E
E
-
V
R
K
-
V
-
K
R
S
E
N
G
-
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
-
S
G
V
P
---
I
V
ET
L
A
--
N
R
K
L
V
G
I
I
T
N
R
D
M
----
R
-
F
I
-
S
D
Y
N
A
P
----------
I
S
---
E
------
H
MTSEH
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
-
I
K
D
I
E
K
V
I
E
F
P
HA
A
-
K
-
D
-
E
-
F
G
R
L
L
V
A
A
A
V
G
V
T
S
D
T
F
E
R
A
E
--
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
-
N
R
T
L
I
A
--
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
------
Y
G
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
--
I
Y
Q
G
R
K
Y
K
T
Y
R
--
G
M
G
S
I
A
A
M
K
K
-------------------------
N
K
-
L
V
P
E
G
I
E
----
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
N
A
-----
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
-----
71
PsiBlast_CBE
88.23
32%
-111
- C1 -
4DQW
7
?
A:
[29-486]
--------------
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
-
P
K
----
D
V
S
L
K
--
T
RL
T
---------
R
-
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
-
G
I
E
Q
Q
---
A
A
E
-
V
R
K
-
V
-
K
-
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
-
Y
G
-
F
S
G
F
---
P
V
--
V
E
--
Q
G
E
L
V
G
I
V
-------
T
G
R
-
D
L
-
R
V
K
P
N
A
GDTVAAIMTP
K
D
---
K
------
L
------
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
--
A
-
S
K
D
-
E
-
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
--
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
--
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E---------------------------------------------------------------------
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
Q
P
-----
Q
F
V
R
I
T
G
-------------
8
PsiBlast_PDB
86.94
33%
-93
- C1 -
4FXS
3
?
A:
[11-473]
--------------
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
--
D
L
R
T
R
--
L
--
T
---------
K
-
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
-
S
I
E
Q
Q
---
A
A
Q
-
V
H
Q
-
V
-
K
-
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
T
H
Y
----
H
G
F
A
G
F
P
V
V
--
T
E
--
N
N
E
L
V
G
I
I
T
G
R
D
V
R
F
V
T
D
-
L
T
-
K
S
V
A
A
V
----------
M
T
PKE
R
------
L
------
A
T
V
K
E
G
----
E
V
Q
E
K
M
H
---
V
E
K
I
L
V
V
N
D
E
F
Q
L
K
G
M
I
T
A
K
-----
E
S
K
P
N
--
A
-
C
K
D
-
E
-
Q
G
R
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
K
G
S
S
D
R
Y
F
Q
T
------------
A
D
--
K
----
L
V
P
E
G
I
E
----
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
------
70
PsiBlast_CBE
85.85
32%
-114
- C1 -
4DQW
5
?
B:
[29-486]
--------------
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
-
P
K
----
D
V
S
L
K
--
T
RL
T
---------
R
-
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
-
G
I
E
Q
Q
---
A
A
E
-
V
R
K
-
V
-
K
-
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
-
Y
G
-
F
S
G
F
---
P
V
--
V
E
--
Q
G
E
L
V
G
I
V
-------
T
G
R
-
D
L
-
R
V
----DTVAAIMTP-
K
D
---
K
------
L
------
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
--
A
-
S
K
D
-
E
-
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
--
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
--
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
---------------------------------------------------------------------------
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
Q
P
-----
Q
F
V
R
I
T
G
-------------
133
HHSearch
84.00
38%
-89
- C1 -
4R7J
8
?
A:
[7-372]
----------
V
K
R
A
L
T
F
E
D
V
L
L
R
P
G
Y
S
E
V
L
-
P
--
K
--
E
V
K
I
H
--
T
--
K
L--------
T
K
N
I
T
L
N
M
P
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
R
L
G
G
L
G
V
I
H
K
N
M
-
D
I
A
S
Q
---
V
R
E
-
V
K
R
-
V
-----------------------------
K
K
-
S
E
-----------------------------------------------------------------------------------------
K
K
R
--
K
E
Y
P
--
D
-------------
A
N
K
------------
D
-
N
-
F
G
R
L
R
V
G
A
A
I
G
V
G
Q
--
M
D
R
V
D
--
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
-
N
L
D
L
I
A
--
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
D
E
C
V
E
E
A
N
K
------
F
G
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
--
E
--
L
F
T
-
Y
Q
G
R
Q
Y
K
--
S
Y
R
G
M
G
S
L
G
A
M
Q
K
-------------------------
L
V
P
E
G
I
E
G
----
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
F
Q
K
R
A
-----
E
F
V
E
I
T
T
A
G
L
K
E
S
H
V
H
D
V
T
-
119
HHSearch
81.16
29%
-86
- C1 -
1ME8
3
IMDH_TRIFO
A:
[5-492]
---------
Y
N
E
P
C
H
T
F
N
E
Y
L
L
I
P
G
L
S
T
V
D
C
I
P
-
S
--
N
V
N
L
S
--
T
--
P
L
V
K
F
Q
KGQQ
S
-
E
I
N
L
K
I
P
L
V
S
A
I
M
Q
S
V
S
G
E
K
M
A
I
A
L
A
R
E
G
G
I
S
F
I
F
G
S
Q
-
S
I
E
S
Q
A
A
M
V
H
A
-
V
K
N
-
F
-
K
-
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
H
N
--
E
L
V
-
D
-
S
-
Q
K
R
Y
L
V
G
A
G
I
N
T
R
-
D
F
R
E
R
V
P
--
A
L
V
E
A
G
A
D
V
L
C
I
D
S
S
D
G
F
S
E
W
Q
K
I
T
I
G
W
I
R
E
K
Y
G
D
K
V
K
V
G
A
--
G
N
I
V
D
G
E
G
F
R
Y
L
A
D
A
G
A
D
F
I
K
I
G
I
G
G
G
S
I
C
I
T
R
E
Q
K
G
I
G
R
G
Q
A
T
A
V
I
D
V
V
A
E
R
N
K
Y
F
E
ET
G
I
Y
I
P
V
C
S
D
G
G
I
V
Y
D
Y
H
M
T
L
A
L
A
M
G
A
D
F
I
M
L
G
R
Y
F
A
R
F
E
E
S
P
T
--
R
--
K
V
T
-
I
N
G
S
V
M
K
--
E
Y
W
G
E
G
S
S
R
A
R
N
W
----------------------------
E
G
V
D
S
----
Y
V
P
Y
A
G
K
L
K
D
N
V
E
A
S
L
N
K
V
K
S
T
M
C
N
C
G
A
L
T
I
P
Q
L
Q
S
K
A
-----
K
I
T
L
V
S
S
V
S
I
V
E
G
G
A
H
D
V
I
-
123
HHSearch
81.10
31%
-90
- C1 -
2CU0
1
IMDH_PYRHO
A:
[3-474]
--
K
F
V
E
K
L
E
K
A
I
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
--
P
-
K
--
D
V
D
V
S
--
T
--
R
IT-------
P
-
N
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
-
G
I
E
E
Q
---
V
E
Q
V
K
R
V
-
K
-
R
-
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
--
A
-
V
-
R
-
D
E
N
G
E
L
L
V
A
A
A
V
--
S
P
F
D
I
K
R
A
I
--
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
-
V
-
D
A
D
F
I
V
--
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
------
Y
G
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
--
K
--
E
V
I
-
I
N
G
R
K
Y
K
--
Q
Y
R
G
M
G
S
L
G
A
M
M
K
------------------Y-
M
K
T
R
K
F
V
P
E
G
V
E
G
----
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
K
E
K
G
-----
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
6
PsiBlast_PDB
80.99
32%
-85
- C1 -
2CU0
1
IMDH_PYRHO
A:
[8-469]
----
L
E
K
-
A
I
K
G
Y
--
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
-
P
K
----
D
V
D
V
S
--
T
RI
T
---------
P
-
N
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
-
G
I
E
E
Q
---
V
E
Q
-
V
K
R
-
V
-
K
R
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
--
A
-
V
R
D
-
E
-
N
G
E
L
L
V
A
A
A
V
S
-
P
F
D
I
-
K
R
A
I
--
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
-
K
V
-
D
A
D
F
I
V
--
G
N
I
A
N
P
K
A
V
D
D
L
T
F
A
D
A
--
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
------
Y
G
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
--
K
--
E
V
I
-
I
N
G
R
K
Y
K
--
Q
Y
R
G
M
G
S
L
G
A
M
M
-
K
-----------------YM
K
T
R
K
-
F
V
P
E
G
V
E
----
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
K
E
K
G
-----
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
-----
125
HHSearch
79.93
36%
-97
- C1 -
1VRD
-
?
A:
[1-457]
----------
M
K
E
A
L
T
F
D
D
V
L
L
V
P
Q
Y
S
E
V
L
-
P
K
-
D
---
V
K
I
D
--
T
--
R
LT-------
R
-
Q
I
R
I
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
A
L
A
K
A
L
A
R
E
G
G
I
G
I
I
H
K
N
L
-
T
P
D
E
Q
---
A
R
Q
-
V
S
I
-
V
K
K
-
T
------------------------------------------------------------------------------------------------------------------------------------------------
I
M
S
V
I
E
H
P
N
--
A
A
R
-
D
-
E
-
K
G
R
L
L
V
G
A
A
V
G
T
S
P
E
T
M
E
R
V
E
--
K
L
V
K
A
G
V
D
V
I
V
I
D
T
A
H
G
H
S
R
R
V
I
E
T
L
E
M
I
K
A
D
Y
P
-
D
L
P
V
V
A
--
G
N
V
A
T
P
E
G
T
E
A
L
I
K
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
M
E
C
S
E
V
A
R
K
------
Y
D
V
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
L
A
A
G
A
E
S
V
M
V
G
S
I
F
A
G
T
E
E
A
P
G
--
E
--
T
I
L
-
Y
Q
G
R
K
Y
K
--
A
Y
R
G
M
G
-------------------------------------
I
E
G
----
M
V
P
Y
K
G
T
V
K
D
V
V
H
Q
L
V
G
G
L
R
S
G
M
G
Y
I
G
A
R
T
I
K
E
L
Q
E
K
A
-----
V
F
V
K
I
T
--------------
1
PsiBlast_PDB
79.30
37%
-94
- C1 -
1VRD
-
?
A:
[5-457]
--------------
L
T
F
D
D
V
L
L
V
P
Q
Y
S
E
V
L
-
P
K
D
V
--
K
I
D
T
R
--
L
--
T
---------
R
-
Q
I
R
I
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
A
L
A
K
A
L
A
R
E
G
G
I
G
I
I
H
K
N
L
T
P
D
E
Q
A
---
R
Q
V
-
S
I
V
-
K
-
K
-
T
-------------------------------------------------------------------------------------------------------------------------------------------------
I
M
S
V
I
E
H
P
N
A
A
-
R
-
D
-
E
-
K
G
R
L
L
V
G
A
A
V
G
T
S
P
E
T
M
E
R
V
E
--
K
L
V
K
A
G
V
D
V
I
V
I
D
T
A
H
G
H
S
R
R
V
I
E
T
L
E
M
I
K
A
D
Y
P
-
D
L
P
V
V
A
--
G
N
V
A
T
P
E
G
T
E
A
L
I
K
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
M
E
C
S
E
V
A
R
K
------
Y
D
V
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
L
A
A
G
A
E
S
V
M
V
G
S
I
F
A
G
T
E
E
A
P
G
--
E
--
T
I
L
-
Y
Q
G
R
K
Y
K
--
A
Y
R
G
M
G
-------------------------------------
I
E
----
G
M
V
P
Y
K
G
T
V
K
D
V
V
H
Q
L
V
G
G
L
R
S
G
M
G
Y
I
G
A
R
T
I
K
E
L
Q
E
K
A
-----
V
F
V
K
I
T
--------------
126
HHSearch
79.28
32%
-99
- C1 -
1EEP
1
IMDH_BORBU
A:
[5-390]
---------
I
T
K
E
A
L
T
F
D
D
V
S
L
I
P
R
K
S
S
V
L
--
P
-
S
--
E
V
S
L
K
--
T
--
Q
LT-------
K
-
N
I
S
L
N
I
P
F
L
S
S
A
M
D
T
V
T
E
S
Q
M
A
I
A
I
A
K
E
G
G
I
G
I
I
H
K
N
M
-
S
I
E
A
Q
---
R
K
E
-
I
E
K
-
V
-
K
---
T
Y
-
K
------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
N
A
-
C
-
K
-
D
-
L
-
N
N
K
L
R
V
G
A
A
V
S
I
D
I
D
T
I
E
R
V
E
--
E
L
V
K
A
H
V
D
I
L
V
I
D
S
A
H
G
H
S
T
R
I
I
E
L
I
K
K
I
K
T
K
Y
P
-
N
L
D
L
I
A
--
G
N
I
V
T
K
E
A
A
L
D
L
I
S
V
G
A
D
C
L
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
I
C
D
V
Y
E
A
C
N
N
------
T
N
I
C
I
I
A
D
G
G
I
R
F
S
G
D
V
V
K
A
I
A
A
G
A
D
S
V
M
I
G
N
L
F
A
G
T
K
E
S
P
S
--
E
--
E
I
I
-
Y
N
G
K
K
F
K
--
S
-------------------------------------------------
M
V
P
Y
S
G
K
L
K
D
I
L
T
Q
L
K
G
G
L
M
S
G
M
G
Y
L
G
A
A
T
I
S
D
L
K
I
N
S
-----
K
F
V
K
I
S
H
S
------------
128
HHSearch
77.77
35%
-98
- C1 -
3FFS
-
IMDH_CRYPV
A:
[5-379]
---------
N
I
G
K
G
L
T
F
E
D
I
L
L
V
P
N
Y
S
E
V
L
--
P
-
R
--
E
V
S
L
E
--
T
--
K
LT-------
K
-
N
V
S
L
K
I
P
L
I
S
S
A
M
D
T
V
T
E
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
H
K
N
M
-
D
M
E
S
Q
---
V
N
E
-
V
L
K
-----
V
K
N
W
-
I
------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
S
N
E
-
N
-
L
-
D
-
N
-
K
G
R
L
R
V
G
A
A
I
G
V
N
---
I
E
R
A
K
--
L
L
V
E
A
G
V
D
V
I
V
L
D
S
A
H
G
H
S
L
N
I
I
R
T
L
K
E
I
K
S
K
-
M
-
N
I
D
V
I
V
--
G
N
V
V
T
E
E
A
T
K
E
L
I
E
N
G
A
D
G
I
K
V
G
I
---------
I
V
A
G
V
G
V
P
Q
I
T
A
I
E
K
C
S
S
V
A
S
K
------
F
G
I
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
V
G
A
S
S
V
M
I
G
S
I
L
A
G
T
E
E
S
P
G
--
E
--
K
E
L
-
I
G
D
T
V
Y
K
--
Y
-------------------------------------------------
R
V
K
Y
K
G
E
M
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
A
S
I
E
E
L
W
K
K
S
-----
S
Y
V
E
I
T
T
S
------------
122
HHSearch
77.49
34%
-104
- C1 -
5AHN
2
?
A:
[6-467]
-----------
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
-
P
K
-
D
---
V
S
L
K
--
T
--
R
LT-------
R
-
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
-
G
I
E
Q
Q
---
A
A
E
-
V
R
K
-
V
K
K
-
H
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
--
A
S
K
-
D
-
E
-
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
--
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
--
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
-------------------------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
Q
P
-----
Q
F
V
R
I
T
G
A
------------
120
HHSearch
77.16
28%
-88
- C1 -
4AF0
2
?
A:
[59-537]
-------------
G
L
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
-
A
S
-
D
---
V
S
L
Q
SK
A
--
T
---------
K
-
N
I
V
L
N
T
P
F
L
S
S
P
M
D
T
V
T
E
D
R
M
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
-
S
A
E
E
Q
---
A
A
M
-
V
R
R
V
K
-
K
-
Y
E
N
----------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
Y
--
A
-
S
K
V
-
P
E
S
K
Q
L
Y
C
G
A
A
I
G
T
R
P
G
D
K
D
R
L
K
--
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
Q
T
Y
P
-
K
I
D
V
I
A
--
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
E
F
A
S
R
------
F
G
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
M
M
G
G
L
L
A
G
T
T
E
S
P
G
--
E
--
Y
F
Y
-
H
E
G
K
R
V
K
--
V
Y
R
G
M
G
S
I
E
A
M
E
H
T
-----GLDNAATAR
Y
F
S
--
E
A
D
A
V
K
V
A
Q
G
V
S
G
----
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
F
T
G
L
Q
H
S
L
Q
D
A
A
I
K
S
V
S
E
L
H
S
C
A
R
S
GS
L
R
F
E
L
R
T
A
S
------------
69
PsiBlast_CBE
75.66
32%
-104
- C1 -
5AHN
2
?
A:
[9-467]
--------------
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
-
P
K
----
D
V
S
L
K
--
T
RL
T
---------
R
-
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
-
G
I
E
Q
Q
---
A
A
E
-
V
R
K
-
V
-
K
-
K
H
----------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
--
A
-
S
K
D
-
E
-
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
--
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
--
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
-------------------------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
Q
P
-----
Q
F
V
R
I
T
G
A
------------
31
PsiBlast_CBE
66.49
44%
-80
- C1 -
4MYA
3
?
B:
[115-370]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
--
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
--
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
--
I
Y
Q
G
R
Q
F
K
V
Y
R
-----
G
M
G
S
V
G
A
-
M
E
K
-----------------------
K
L
V
P
E
G
I
E
----
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
-----
41
PsiBlast_CBE
66.05
44%
-78
- C1 -
4MY8
7
?
B:
[115-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
--
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
--
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
ET
E
--
I
Y
Q
G
R
Q
F
K
V
Y
R
-----
G
M
G
S
V
G
A
-
M
E
K
------------------------
L
V
P
E
G
I
E
----
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
---------
40
PsiBlast_CBE
65.81
44%
-78
- C1 -
4MY8
4
?
C:
[115-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
--
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
--
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
ET
E
--
I
Y
Q
G
R
Q
F
K
V
Y
R
-----
G
M
G
S
V
G
A
-
M
E
K
-----------------------
K
L
V
P
E
G
I
E
----
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
---------
49
PsiBlast_CBE
65.20
43%
-77
- C1 -
4MZ1
6
?
C:
[111-367]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
N
-
F
G
R
L
R
V
G
A
A
I
G
----
V
G
Q
M
D
R
VD
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
-
N
L
D
L
I
A
--
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
D
E
C
V
E
E
A
N
K
------
F
G
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
--
E
--
L
F
T
Y
Q
G
R
Q
-
Y
K
--
S
Y
R
G
M
G
S
L
G
A
-
M
Q
K
------------------------
L
V
P
E
G
I
E
----
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
F
Q
K
R
A
-----
E
F
V
E
I
T
T
A
G
L
K
E
S
H
------
77
PsiBlast_CBE
65.13
41%
-80
- C1 -
4IX2
3
?
D:
[94-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
R
G
M
-----------------------------------
P
E
G
I
E
----
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
------
78
PsiBlast_CBE
64.93
41%
-77
- C1 -
4IX2
3
?
C:
[94-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
R
G
M
-----------------------------------
P
E
G
I
E
----
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
------
50
PsiBlast_CBE
64.89
43%
-80
- C1 -
4MZ1
5
?
B:
[111-367]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
N
-
F
G
R
L
R
V
G
A
A
I
G
----
V
G
Q
M
D
R
V
D
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
-
N
L
D
L
I
A
--
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
D
E
C
V
E
E
A
N
K
------
F
G
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
--
E
--
L
F
T
Y
Q
G
R
Q
-
Y
K
--
S
Y
R
G
M
G
S
L
G
A
-
M
Q
K
------------------------
L
V
P
E
G
I
E
----
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
F
Q
K
R
A
-----
E
F
V
E
I
T
T
A
G
L
K
E
S
H
------
82
PsiBlast_CBE
64.40
41%
-76
- C1 -
4FO4
3
?
A:
[94-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
R
G
M
G
S
L
G
A
-
M
S
------------------------
K
L
V
P
E
G
I
E
----
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
------
80
PsiBlast_CBE
64.09
41%
-77
- C1 -
4IX2
2
?
A:
[94-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
R
G
M
-----------------------------------
P
E
G
I
E
----
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
------
79
PsiBlast_CBE
64.00
41%
-76
- C1 -
4IX2
2
?
B:
[94-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
R
G
M
-----------------------------------
P
E
G
I
E
----
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
------
81
PsiBlast_CBE
63.59
41%
-76
- C1 -
4FO4
3
?
B:
[94-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
R
G
M
G
S
L
G
A
-
M
S
------------------------
K
L
V
P
E
G
I
E
----
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
------
74
PsiBlast_CBE
63.42
41%
-89
- C1 -
4QQ3
3
?
A:
[94-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
------------
G
R
S
Y
K
--
A
Y
R
G
M
G
--------------------------------------------
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
------------
76
PsiBlast_CBE
63.34
41%
-73
- C1 -
4QNE
3
?
A:
[94-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
R
G
M
G
S
L
G
A
-
M
S
-------------------------
L
V
P
E
G
I
E
----
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
------
73
PsiBlast_CBE
63.27
41%
-73
- C1 -
4X3Z
4
?
A:
[94-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
R
G
M
G
S
L
G
A
-
M
S
-------------------------
L
V
P
E
G
I
E
----
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
------
75
PsiBlast_CBE
63.15
41%
-75
- C1 -
4QNE
3
?
B:
[94-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
R
G
M
G
S
L
G
A
-
M
S
-------------------------
L
V
P
E
G
I
E
----
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
------
72
PsiBlast_CBE
62.56
41%
-73
- C1 -
4X3Z
3
?
B:
[94-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
R
G
M
G
S
L
G
A
-
M
S
------------------------
K
L
V
P
E
G
I
E
----
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
------
61
PsiBlast_CBE
62.02
42%
-80
- C1 -
4FEZ
5
?
B:
[114-366]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
E
-
Q
G
R
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
-----------------------------------------------
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
------------
19
PsiBlast_PDB
61.96
42%
-82
- C1 -
4FEZ
6
?
A:
[114-366]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
E
-
Q
G
R
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
R
------------------------------------------------
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
------------
134
HHSearch
61.35
44%
-73
- C1 -
4MYA
4
?
A:
[131-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
R
I
D
--
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
--
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
--
E
--
T
E
I
-
Y
Q
G
R
Q
F
K
--
V
Y
R
G
M
G
S
V
G
A
M
E
K
-----------------------
K
K
L
V
P
E
G
I
E
G
----
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
127
HHSearch
59.67
40%
-69
- C1 -
4X3Z
4
?
A:
[110-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
R
V
K
--
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
--
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
--
E
--
V
I
L
-
Y
Q
G
R
S
Y
K
--
A
Y
R
G
M
G
S
L
G
A
M
S
--------------------------
L
V
P
E
G
I
E
G
----
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
-
130
HHSearch
56.02
41%
-74
* C1 *
4ZQM
2
A:
[144-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
R
A
M
--
M
L
V
D
A
G
V
D
V
L
V
V
D
T
A
H
A
H
N
R
L
V
L
D
M
V
G
K
L
K
S
E
V
--
G
D
R
V
E
V
V
G
G
N
V
A
T
R
S
A
A
A
A
L
V
D
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
A
P
Q
I
T
A
I
L
E
A
V
A
A
C
R
P
------
A
G
V
P
V
I
A
D
G
G
L
Q
Y
S
G
D
I
A
K
A
L
A
A
G
A
S
T
A
M
L
G
S
L
L
A
G
T
A
E
A
P
G
--
E
--
L
I
F
-
V
N
G
K
Q
Y
K
--
S
Y
R
G
M
G
S
L
G
A
M
---------------------------
L
V
P
E
G
I
E
G
----
R
V
P
F
R
G
P
L
S
S
V
I
H
Q
L
T
G
G
L
R
A
A
M
G
Y
T
G
S
P
T
I
E
V
L
Q
-
Q
A
-----
Q
F
V
R
I
T
P
A
G
L
----------