@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1887: (2016-05-05 )
MDTVLGLSITPTTLGWVLAEGHGADGAILDRNELELHSGRNAQAIHTAEQLAAEVLLAHEVAAAGDHRLRVIGVTWNAEASAQAALLVESLTGAGFDNVVPVRRLRAIETLAQAIAPVIGYEQIAVCVLEHESATVVMVDTHDGKTQIAVKHVCRGLSGLTSWLTGMFGRDAWRPAGVVVVGSDSEVSEFSWQLERVLPVPVFAQTMAQVTVARGAALAAAQSTEFTDAQLVADSVSQPTVAPRRSRHYAGAAAALAAAAVTFVASLSLAVGIQLAPHNDTGTAKHGAHKPTPRIAKAVAPAVPPPPTVTPPVPARAPRPAAQHEPPARVTSGEALTEPNPPEEQPNASAPQQDRNDSQPITRVLEHIPGAYGDSAPPAE
Atome Classification :
(20 SA)
----------------------.........10........20..-...------...30-.......-..40........50........60...--.--.----...70........80........90-........100----------........110-......-----..120-.......130..---------.....-------140.----...-.---.---.---150------.....-----------------------------------------------------------------------------------.--------------------------------------------------------------------------------------.160.......170----.----...--....180.......190-.......-.--------200..--------.-------....210.......220.......230.......240.......250..---------------.....260.......270.......280....--...290.......300.......310.......320.......330.......340....---...350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------MD
T
V
L
G
L
S
ITPT
T
L
G
W
V
L
AEGHG-AD
G
------
A
I
LD--RN
E
L
E
LH-SGRN
A
Q
A
I
H
T
A
E
Q
L
A
A
E
V
L
L
A
H
E
V
AAA--G--D----
H
R
L
R
V
I
G
V
T
WNAEAS
A
Q
A
A
L
L
V
E
S
L
-TGAGFDNV
V
P
-----------
V
R
R
L
R
A
I
E
T
L
--
A
Q
A
I
A
P
-----VI
G
Y
E
-
Q
I
A
V
C
V
L
EHES
A
---------
T
V
V
M
V
-------DTHD----GK
T
-
Q
---
I
---
A
---
V
K
H
------
V
C
R
G
L
-----------------------------------------------------------------------------------
S
--------------------------------------------------------------------------------------
G
L
T
S
W
L
T
G
M
FGRD-----A----WRP--A
G
V
V
V
VGSDS
E
V
S
E
F
S
--
W
Q
L
E
RVL-P--------V
P
V
F
A
--------
Q
-------
T
M
A
Q
V
T
VARG
A
A
L
AAAQSTEFT
D
A
Q
L
V
A
DSVSQPTVAPRRSRHYA
G
A
A
A
---------------
A
L
A
A
A
A
V
T
F
V
A
S
L
S
L
A
V
G
I
Q
LAPHNDTGTAKH--GAHKP
T
P
R
I
A
K
A
VAPAVPPPPTVTPPVPARAPRPAAQHEPPARVTSGEALTEPNPPEEQP---NASAPQQDRNDSQ
P
I
T
R
V
L
E
HIPGAYGDSAPPAE
32
HHSearch
71.68
19%
-98
- C6 -
1HUX
2
HGDC_ACIFV
A:
[2-258]
----------------------
S
I
Y
T
L
G
I
D
V
G
S
T
A
S
K
C
I
I
L
K
D
G
----
K
------
E
I
V
A
--
K
S
L
V
A
V
G
-
T
G
-
T
S
G
P
----
A
R
S
I
S
E
V
L
E
---
N
A
H
M
--
K
--
K
----
E
D
M
A
F
T
L
A
T
G
Y
G
R
N
S
-----
L
-----
E
--
G
I
-
A
D
K
Q
-----------
M
S
E
L
S
C
H
A
M
G
--
A
S
F
I
W
---------
P
N
-
V
H
T
V
I
D
I
G
G
Q
D
V
---------
K
V
I
H
V
-------
E
N
G
T
----
M
T
N
-
F
---
Q
---
M
---
N
D
K
------
C
A
A
G
T
G
R
F
L
D
V
M
A
N
I
L
EVKVSD
L
A
E
L
G
A
K
ST
K
R
V
A
ISSTC
T
V
F
A
E
S
E
V
I
S
Q
L
S
K
GTD
K
I
D
I
I
A
G
I
H
----------------------
R
--------------------------------------------------------------------------------------
S
V
A
S
R
V
I
G
L
A
N
R
V
----------
G
I
V
--
K
D
V
V
M
T
G
G
V
A
Q
N
Y
G
V
R
--
G
A
L
E
E
G
L
-
G
--------
V
E
I
K
T
--------
S
-------
P
L
A
Q
Y
N
G
A
L
G
A
A
L
Y
A
Y
K
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
69.05
16%
-102
- C6 -
3D2F
3
?
A:
[114-390]
------------------------------------------------------------------------------
S
A
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
--
K
ANIT
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
-
Y
--
N
I
A
D
A
A
-
R
I
A
G
L
N
P
V
R
I
-----------
V
N
D
V
T
A
A
G
V
S
--
Y
G
I
F
K
T
DLPEG
E
E
K
P
R
-
I
V
A
F
V
D
I
G
H
S
S
Y
---------
T
C
S
I
M
-------
A
F
K
K
----
G
Q
L
-
K
---
V
L
G
T
A
---
C
D
K
------
H
F
G
G
R
D
F
---------------------------------------------------------------------------------
D
L
A
I
T
E
H
F
A
D
E
F
K
T
K
YKIDIREN
P
K
A
Y
N
R
I
L
T
A
A
E
K
L
K
K
V
L
S
A
N
T
N
A
P
F
S
V
E
SVMND
V
D
V
S
S
Q
L
S
R
E
E
L
E
E
L
V
K
PLLE---------
R
V
T
E
P
V
T
K
A
L
A
Q
A
-----
K
LSA-
E
E
V
--
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
--
Q
S
I
S
E
A
F
-
G
--------
K
P
L
S
T
--------
T
-------
L
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
68.50
16%
-102
- C6 -
4FL9
3
HSP7C_BOVIN
A:
[116-392]
-------------------------------------------------------------------------------
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
--
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
-
Q
--
A
T
K
D
A
G
-
T
I
A
G
L
N
V
L
R
I
-----------
I
N
E
P
T
A
A
A
I
A
--
Y
G
L
D
K
K
-----
V
G
A
E
R
-
N
V
L
I
F
D
L
G
G
G
T
F
---------
D
V
S
I
L
-------
T
I
A
A
----
G
I
F
-
E
---
V
K
S
T
A
---
G
D
T
------
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
HKKDISEN
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
SLYEG
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
----
R
--------------------------------------------------------------------------------------
G
T
L
D
P
V
E
K
A
L
R
D
A
KLD--
K
----
S
Q
I
--
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
--
K
L
L
Q
D
F
F
-
N
G-------
K
E
L
N
K
--------
S
-------
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
68.47
17%
-111
- C6 -
3QFU
3
GRP78_YEAST
A:
[158-392]
-------------------------------------------------------------------------------------------------------------
V
T
V
P
A
Y
F
N
D
A
Q
R
-
Q
--
A
T
K
D
A
G
-
T
I
A
G
L
N
V
L
R
I
-----------
V
N
E
P
T
A
A
A
I
A
--
Y
G
L
D
K
------
S
D
K
E
H
-
Q
I
I
V
Y
D
L
G
G
G
T
F
---------
D
V
S
L
L
-------
S
I
E
N
----
G
V
F
-
E
VQ
A
T
---
S
---
G
D
T
------
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
HGIDVSDN
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
SQM
S
T
R
I
E
I
D
SFVDG
I
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
----
K
--------------------------------------------------------------------------------------
K
T
L
K
P
V
E
K
V
L
Q
D
S
GLE--
K
----
K
D
V
--
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
--
Q
L
L
E
S
Y
F
D
G
--------
K
K
A
S
K
--------
G
-------
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
67.63
15%
-101
- C6 -
2V7Y
2
DNAK_GEOKA
A:
[113-351]
------------------------------------------------------------------------------------------------------------
V
I
T
V
P
A
Y
F
N
D
A
Q
R
-
Q
--
A
T
K
D
A
G
-
R
I
A
G
L
E
V
E
R
I
-----------
I
N
E
P
T
A
A
A
L
A
--
Y
G
L
D
K
-------
E
E
D
Q
-
T
I
L
V
Y
D
L
G
G
G
T
F
---------
D
V
S
I
L
-------
E
L
G
D
----
G
V
F
-
E
V
K
A
T
---
A
---
G
D
N
------
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
HGIDLSKD
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
VTQTQISLPFISANEN
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
--------------------------------------------------------------------------------------
R
T
M
G
P
V
R
Q
A
L
Q
D
A
GLT--
P
----
A
D
I
--
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
--
E
A
I
K
R
E
L
-
G
--------
K
E
P
H
K
--------
G
-------
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
67.31
16%
-113
- C6 -
4GNI
1
?
A:
[154-402]
------------------------------------------------------------------------------------------------------------
V
I
T
I
P
T
N
F
T
E
K
Q
K
-
A
--
A
L
I
A
A
A
-
A
A
A
D
L
E
V
L
Q
L
-----------
I
S
E
P
A
A
A
V
L
A
--
Y
D
A
----------
S
D
K
-
I
I
V
V
A
D
L
G
G
S
R
S
---------
D
V
T
V
L
-------
A
S
R
S
----
G
M
Y
-
T
I
L
A
T
---
V
---
H
D
Y
------
E
Y
H
G
I
A
L
D
K
V
L
I
D
H
F
S
K
E
F
L
K
K
N
PGAKDPREN
P
R
S
L
A
K
L
R
L
E
A
E
S
T
K
R
A
L
S
R
ST
N
A
S
F
S
V
E
SLIDG
L
D
F
A
S
T
I
N
R
L
R
Y
E
T
I
A
R
T
V
F
--
E
--------------------------------------------------------------------------------------
G
F
N
R
L
V
E
S
A
V
K
K
A
-----
G
LDP-
L
D
V
--
D
E
V
I
M
S
G
G
T
S
N
T
P
R
I
A
--
A
N
F
R
Y
I
F
-
P
--------
E
S
T
R
I
LAPSTDPS
A
-------
L
N
P
S
E
L
Q
A
R
G
A
A
L
Q
A
S
L
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
66.51
15%
-104
- C6 -
3I33
3
HSP72_HUMAN
A:
[163-401]
-------------------------------------------------------------------------------------------------------------
I
T
V
P
A
Y
F
N
D
S
Q
R
-
Q
--
A
T
K
D
A
G
-
T
I
T
G
L
N
V
L
R
I
-----------
I
N
E
P
T
A
A
A
I
A
--
Y
G
L
D
K
K
GC---
A
G
G
E
K
-
N
V
L
I
F
D
L
G
G
G
T
F
---------
D
V
S
I
L
-------
T
I
E
D
----
G
I
F
-
E
---
V
---
K
S
T
A
G
D
T
------
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
K
HKKDIGPN
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
ST
Q
A
S
I
E
I
D
SLYEG
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
----
R
--------------------------------------------------------------------------------------
G
T
L
E
P
V
E
K
A
L
R
D
A
KLD--
K
----
G
Q
I
--
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
--
K
L
L
Q
D
F
F
N
G
--------
K
E
L
N
K
--------
S
-------
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
66.14
16%
-99
- C6 -
5E84
6
GRP78_HUMAN
A:
[118-383]
------------------------------------------------------------------------------
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
--
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
-
Q
--
A
T
K
D
A
G
-
T
I
A
G
L
N
V
M
R
I
-----------
I
N
E
P
T
A
A
A
I
A
--
Y
G
L
D
-
K
-----
R
E
G
E
K
-
N
I
L
V
F
D
L
G
G
G
A
F
---------
D
V
S
L
L
-------
T
I
D
N
----
G
V
F
-
E
V
V
A
T
---
N
---
G
D
T
------
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
TGKDVRKD
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
SQH
Q
A
R
I
E
I
E
SFYEG
E
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
----
R
--------------------------------------------------------------------------------------
S
T
M
K
P
V
Q
K
V
L
E
D
S
-----
D
LKK-
S
D
I
--
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
--
Q
L
V
K
E
F
F
-
N
G-------
K
E
P
S
R
--------
G
-------
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
64.75
15%
-35
- C3 -
3J9O
-
?
B:
[79-505]
------------V
I
D
K
L
I
D
L
Q
V
N
S
I
I
S
N
D
E
F
R
A
L
E
Q
E
W
L
K
V
Q
E
V
C
-
Q
E
D
YDN
V
E
V
S
I
L
D
V
K
K
E
E
L
Q
Y
D
-
F
E
R
N
L
Y
D
I
S
S
S
D
F
F
K
K
--
V
Y
V
S
E
F
D
Q
Y
--
G
--
G
----
E
P
Y
G
A
I
L
G
L
Y
N
F
E
N
T
T
N
D
I
I
W
L
T
G
M
-
G
M
V
A
K
N
S
H
A
P
F
I
A
S
I
D
KSFFG
V
K
D
L
S
E
I
T
H
I
KS
F
E
A
L
L
E
-----
H
P
R
Y
K
-
E
W
N
D
F
R
N
L
D
V
A
A
---------
Y
I
G
L
T
V
G
DFMLR
Q
P
Y
N
----
P
E
N
-
N
---
P
---
V
---
Q
Y
K
------
L
M
E
G
F
-----------------------------------------------------------------------------------
N
--------------------------------------------------------------------------------------
E
F
V
D
Y
--
D
K
N
E
S
Y
-----
L
----
W
G
P
--
A
S
I
H
L
V
K
N
M
M
R
S
Y
D
K
T
RW
F
Q
Y
I
R
G
V
-
E
--------
S
G
G
Y
V
--------
K
-------
N
L
V
A
C
V
Y
D
N
K
G
I
L
E
T
K
S
P
L
N
V
L
F
A
D
Y
M
E
L
S
L
A
N
I
G
L
I
P
F
V
S
E
K
G
T
S
N
A
C
F
FSVNSAKKVEEFVD
G
F
D
S
A
N
S
R
L
I
A
N
L
S
Y
T
M
C
I
S
R
I
S
H
Y
I
K
C
V
I
R
D
KI
G
S
I
V
D
V
E
S
I
Q
K
I
L
S
D
W
I
S
E
F
V
T
T
V
Y
Q
-----
P
T
P
L
E
M
A
R
Y
P
F
R
N
V
S
I
E
V
K
T
I
P
G
K
P
G
W
Y
S
C
K
I
N
V
I
P
H
I
Q
F
E
G
M
N
T
T
M
T
I
D
T
R
L
E
P
E
L
F
G
T
N
N
----
36
HHSearch
62.22
15%
-109
- C6 -
4J8F
11
F10A1_RAT (first)
A:
[150-386]
------------------------------------------------------------------------------------------------------------
V
I
T
V
P
A
Y
F
N
D
S
Q
R
-
Q
--
A
T
K
D
A
G
-
V
I
A
G
L
N
V
L
R
I
-----------
I
N
E
P
T
A
A
A
I
A
--
Y
G
L
D
R
T
-----
G
K
G
E
R
-
N
V
L
I
F
D
L
G
G
G
T
F
---------
D
V
S
I
L
-------
T
I
D
D
----
G
I
F
-
E
---
V
K
A
T
A
---
G
D
T
------
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
HKKDISQN
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
SLFEG
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
----
R
--------------------------------------------------------------------------------------
S
T
L
E
P
V
E
K
A
L
R
D
A
KLD--
K
----
A
Q
I
--
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
--
K
L
L
Q
D
F
F
-
N
G-------
R
D
L
N
K
--------
S
-------
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
60.43
15%
-102
- C6 -
4RTF
2
?
D:
[148-388]
-------------------------------------------------------------------------------------------------------------
I
T
T
P
A
Y
F
N
D
A
Q
R
-
Q
--
A
T
K
D
A
G
-
Q
I
A
G
L
N
V
L
R
I
-----------
V
N
E
P
T
A
A
A
L
A
--
Y
G
L
D
-
K
-------
K
E
Q
-
R
I
L
V
F
D
L
G
G
G
T
F
---------
D
V
S
L
L
-------
E
I
G
-----
G
V
V
-
E
VRA
T
---
S
---
G
D
N
------
H
L
G
G
D
DWDQRVVDWLVDKFKGTSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDNPLFLDEQLTRAEF----------
Q
RITQDLLD------------------------------------------------------------------------------
R
T
R
K
P
F
Q
S
V
I
A
D
T
GIS--
V
----
S
E
I
--
D
H
V
V
L
V
G
G
S
T
R
M
P
A
V
T
--
D
L
V
K
E
L
T
-
G
G-------
K
E
P
N
K
--------
G
-------
V
N
P
D
E
V
V
A
V
G
A
A
L
Q
A
G
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
59.12
14%
-28
- C4 -
2VDU
-
TRM82_YEAST
B:
[2-436]
SVIHPLQ
N
L
L
T
S
RDGS
L
V
F
A
I
I
K
N
C
I
L
S
F
K
Y
Q
S
P
N
-
H
W
E
F
A
-
G
K
W
-
S
D
D
------
F
P
I
Y
--
S
Y
I
R
N
L
R
L
T
S
D
E
S
R
L
I
A
C
A
D
S
D
--
K
S
L
L
V
F
D
V
D
K
T
--
S
--
K
NVL-
K
L
R
K
R
F
C
F
S
K
R
P
N
A
I
S
I
A
E
D
D
T
T
V
I
-
I
A
D
K
F
G
D
V
Y
S
-----------
I
D
-
I
N
S
I
P
E
E
--
K
F
T
Q
E
P
-----
I
L
G
H
V
S
M
L
T
D
V
H
L
I
K
D
S
D
---------
G
H
Q
F
I
-------
I
T
S
D
----
R
D
E
-
H
---
I
---
K
---
I
S
H
Y
PQCFI
V
D
K
W
L
-----------------------------------------------------------------------------------
F
--------------------------------------------------------------------------------------
G
H
K
H
F
V
S
S
I
C
C
G
K
-----
D
----
Y
-----
L
L
L
S
A
G
G
D
D
K
I
F
A
W
D
--
W
K
T
G
K
N
L
-
S
----------------------------------
T
F
D
Y
N
S
L
I
K
P
Y
L
N
D
Q
H
L
--
A
I
I
E
F
A
V
S
K
I
I
K
S
K
N
L
P
---------------------------
F
V
A
F
F
V
E
A
T
K
C
I
I
I
L
E
M
S
E
K
Q
K
G
D
L
A
L
K
--
Q
I
I
T
F
P
Y
N
V
I
S
L
S
A
H
--
N
D
E
F
Q
V
T
L
D
N
K
E
S
S
G
V
Q
K
N
F
A
K
F
I
E
Y
N
L
N
E
N
S
F
V
V
N
N
E
K
S
N
E
F
---
D
S
A
I
I
Q
S
V
Q
G
D
S
N
L
V
T
K
-
K
E
E
I
Y
P
L
Y
N
V
S
S
L
---
26
HHSearch
57.45
13%
-97
- C6 -
4JNE
7
DNAK_ECOLI
A:
[140-382]
-------------------------------------------------------------------------------------------------------------
I
T
V
P
A
Y
F
N
D
A
Q
R
-
Q
--
A
T
K
D
A
G
-
R
I
A
G
L
E
V
K
R
I
-----------
I
N
E
P
T
A
A
A
L
A
--
Y
G
L
D
-
K
-----
G
T
G
N
R
-
T
I
A
V
Y
D
L
G
G
G
A
F
---------
D
I
S
I
I
-------
E
I
D
E
V
DG
E
K
T
F
-
E
V
L
A
T
---
N
---
G
D
T
------
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
QGIDLRND
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
AQ
Q
T
D
V
N
L
P
YITADAT
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
--------------------------------------------------------------------------------------
R
S
I
E
P
L
K
V
A
L
Q
D
A
-----
G
LSV-
S
D
I
--
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
--
K
K
V
A
E
F
F
-
G
--------
K
E
P
R
K
--------
D
-------
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
56.44
10%
-88
- C6 -
3WQT
3
FTSA_STAAR
A:
[183-389]
-----------------------------------------------------------------------------------------------------------------------------
N
M
I
K
C
V
-
E
A
C
G
V
D
V
L
D
V
-----------
Y
S
D
A
Y
N
Y
G
S
I
--
L
T
---
A
-----
T
E
K
E
L
-
G
A
C
V
I
D
I
G
E
D
V
T
---------
Q
V
A
F
Y
-------
E
R
------
G
E
L
-
V
---
D
---
A
---
D
S
I
------
E
M
A
G
R
D
I
T
D
D
I
A
Q
G
LNTS
Y
E
T
A
E
K
V
K
H
Q
YGHAFYDSASDQD
I
F
T
V
E
Q
VDSD
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
-------------------
E
--------------------------------------------------------------------------------------
E
I
F
F
E
V
F
D
V
L
Q
D
L
-----
G
LT--
K
V
N
--
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
--
E
L
L
S
D
M
V
-
S
--------
E
K
V
R
I
--------
H
T
P
SQMGI
R
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
55.85
11%
-102
- C6 -
4CZG
3
?
A:
[101-327]
------------------------------------------------------------------------------------------------------------
I
V
C
V
P
S
G
A
T
A
V
E
R
-
R
--
A
I
N
D
S
C
-
L
N
A
G
A
R
R
V
G
L
-----------
I
D
E
P
M
A
A
A
I
G
--
A
G
L
P
I
-------
H
E
P
T
-
G
S
M
V
V
D
I
G
G
G
T
T
---------
E
V
A
V
L
-------
S
L
S
G
----
I
V
Y
---------
S
---
R
S
V
------
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
HHN
L
L
I
G
E
T
T
A
E
R
I
K
K
E
IGTARAPG
L
S
I
D
V
K
G
R
D
LMQG
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
-------------
G
--------------------------------------------------------------------------------------
Q
I
V
E
A
V
K
V
A
L
E
A
T
-----
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
--
A
E
I
R
D
H
T
-
G
--------
L
P
V
T
V
--------
A
-------
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
55.81
13%
-51
- C6 -
1WOQ
3
?
A:
[11-263]
----------------------
N
A
P
L
I
G
I
D
I
G
G
T
G
I
K
G
G
I
V
D
L
----
K
K
------
G
K
L
L
--
G
E
R
F
R
V
P
-
T
P
Q
P
A
T
P
E
S
V
A
E
A
V
A
L
V
V
A
E
L
S
A
R
P
E
A
--
P
--
A
----
A
G
S
P
-
V
G
V
T
F
P
G
I
I
Q
H
G
V
V
H
S
A
A
N
--------
V
D
K
S
-----------
W
L
N
T
D
I
D
A
L
L
--
T
A
R
L
G
R
-----
P
V
E
V
I
-
N
D
A
D
A
A
G
L
A
E
A
R
YGAGAGVK
G
T
V
L
V
I
-------
T
L
G
T
----
G
I
G
-
S
---
A
---
F
---
I
F
D
------
G
K
L
V
P
-----------------------------------------------------------------------------------
N
--------------------------------------------------------------------------------------
A
E
L
G
H
L
E
I
D
G
H
D
A
-----
E
----
T
K
A
--
S
A
V
A
R
E
R
D
G
L
S
W
D
E
Y
S
--
V
L
L
Q
R
Y
F
-
S
--------
H
V
E
F
L
--------
F
-------
S
P
E
L
F
I
V
G
G
G
I
S
K
R
A
D
E
Y
-----
L
P
N
L
R
L
R
T
P
I
V
P
A
V
L
R
N
E
A
G
I
V
G
A
A
I
---------------
E
I
A
L
Q
H
-----------------------------------------------------------------------------------------------------------------------------
47
Fugue
53.14
16%
-60
- C4 -
3DNF
2
ISPH_AQUAE
A:
[1-281]
----------------------------------
M
V
D
I
I
I
A
E
H
A
G
F
C
F
G
------
V
K
R
A
--
V
K
L
A
E
E
S
-
L
K
E
S
Q
G
K
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
--
G
------------
V
F
P
S
Q
G
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
-----------
K
K
G
L
K
V
I
D
------
A
T
C
P
-----
Y
V
K
A
V
-
H
E
A
V
C
Q
L
T
R
E
G
Y
---------
F
V
V
L
V
-------
G
E
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
E
V
I
G
T
L
G
Y
L
-----
R
----
A
C
N
--
G
K
G
I
V
V
E
T
L
E
D
I
G
E
A
L
--
K
H
E
-----
R
--------
V
G
I
V
A
--------
Q
-------
T
--------------
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
K
V
I
N
T
I
C
N
A
T
S
L
R
---------------
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
-------------
G
--
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
--
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
-----------------
A
S
T
P
------
D
W
I
I
E
Q
V
K
S
R
I
Q
E
I
---------
43
Fugue
52.85
11%
-52
- C6 -
2E2O
1
?
A:
[1-299]
----------------------
M
M
I
I
V
G
V
D
A
G
G
T
K
T
K
A
V
A
Y
D
C
E
G
-
N
F
I
------
G
E
G
S
--
S
G
P
G
N
Y
H
-
N
V
G
L
T
R
A
I
E
N
I
K
E
A
V
K
I
A
A
-------------
K
----
G
E
A
D
V
V
G
M
G
V
A
G
L
D
S
K
F
D
W
E
N
F
T
P
L
-
A
S
-------
L
-----------
I
A
P
K
V
I
I
Q
H
D
--
G
V
I
A
L
F
-----
A
E
T
L
G
-
E
P
G
V
V
V
I
A
-
G
T
G
---------
S
V
V
E
G
-------
Y
N
G
K
----
E
F
L
-
R
---
V
---
G
---
G
R
G
------
W
L
L
S
D
-----------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------
G
S
----
A
Y
W
V
G
R
K
-----
A
----
L
R
K
--
V
L
K
M
M
D
G
L
E
N
K
T
-------
I
L
Y
N
K
V
-
L
--------
K
T
I
N
V
--------
K
-------
D
L
D
E
L
V
M
W
S
Y
T
S
S
C
Q
I
D
L
V
A
S
I
A
K
A
V
D
E
A
A
N
E
G
D
T
V
A
M
D
I
L
K
Q
G
A
E
L
L
A
---------------
S
Q
A
V
Y
L
A
R
K
I
G
T
N
K
V
Y
L
K
----------------
G
G
M
F
R
S
N
I
Y
H
K
F
F
T
L
Y
L
E
K
E
G
I
I
S
D
L
G
K
R
S
P
E
I
G
A
V
I
L
A
Y
K
E
V
G
C
D
I
K
K
L
I
S
D
--------------------------------------------
40
HHSearch
52.57
10%
-112
* C6 *
4PL7
1
ACT_PICPG (first)
A:
[106-378]
--------------------------------------------------------------------------------------------------------------
T
E
A
P
M
N
P
K
S
N
R
-
E
--
K
M
T
Q
I
M
F
E
T
F
N
V
P
A
F
Y
V
-----------
S
I
Q
A
V
L
S
L
Y
A
--
S
G
------------
R
T
-
T
G
I
V
L
D
S
G
D
G
V
T
---------
H
V
V
P
I
-------
Y
A
------
G
F
S
L
P
H--
A
---
I
---
L
R
I
------
D
L
A
G
R
D
L
---------------------------------------------------------------------------------
T
D
Y
L
M
K
I
L
S
E
R
GYTFST
S
A
E
R
E
I
V
R
D
I
K
E
K
L
C
Y
V
A
LD
F
D
Q
E
L
Q
T
S
S
Q
SSSI
E
K
S
Y
E
L
PDG
Q
V
I
T
I
G
NERFRAPEALFHPSVLGLEAS
G
I
D
Q
T
T
Y
N
S
I
M
K
C
DVDV
R
K
----
E
L
Y
--
S
N
I
V
M
S
G
G
T
T
M
F
P
G
I
A
--
E
R
M
Q
K
E
L
-
T
A
L
APSS
M
K
V
K
I
S
A
--------
P
-------
P
E
R
K
Y
S
V
W
I
G
G
S
I
L
A
S
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
52.41
8%
-91
- C6 -
3WT0
1
FTSA_STAAW
A:
[176-390]
-----------------------------------------------------------------------------------------------------------------
I
A
I
Q
K
S
I
L
-
I
--
N
M
I
K
C
V
-
E
A
C
G
V
D
V
L
D
V
-----------
Y
S
D
A
Y
N
Y
G
S
I
--
L
T
---
A
-----
T
E
K
E
L
-
G
A
C
V
I
D
I
G
E
D
V
T
---------
Q
V
A
F
Y
-------
E
R
G
------
E
L
-
V
---
D
---
A
---
D
S
I
------
E
M
A
G
R
D
I
T
D
D
I
A
Q
G
L
NTS
Y
E
T
A
E
K
V
K
H
Q
YGHAFYDSASDQ
D
I
F
T
V
E
Q
VDSD
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
-------------------
E
--------------------------------------------------------------------------------------
E
I
F
F
E
V
F
D
V
L
Q
D
L
-----
G
LT--
K
V
N
--
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
--
E
L
L
S
D
M
V
-
S
--------
E
K
V
R
I
--------
H
T
P
SQMGI
R
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------