@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2540c: (2016-05-11 )
MLRWITAGESHGRALVAVVEGMVAGVHVTSADIADQLARRRLGYGRGARMTFERDAVTVLSGIRHGSTLGGPIAIEIGNTEWPKWETVMAADPVDPAELADVARNAPLTRPRPGHADYAGMLKYGFDDARPVLERASARETAARVAAGTVARAFLRQALGVEVLSHVISIGASAPYEGPPPRAEDLPAIDASPVRAYDKAAEADMIAQIEAAKKDGDTLGGVVEAVALGLPVGLGSFTSGDHRLDSQLAAAVMGIQAIKGVEIGDGFQTARRRGSRAHDEMYPGPDGVVRSTNRAGGLEGGMTNGQPLRVRAAMKPISTVPRALATVDLATGDEAVAIHQRSDVCAVPAAGVVVETMVALVLARAALEKFGGDSLAETQRNIAAYQRSVADREAPAARVSG
Atome Classification :
(20 SA)
.........10........20........30........40........50.-----.......60........70........80.-.-......90........100-.......110.......120.......130.......140.......150.......160.......170-.....-..180-.-..---.------...190---........200.......210.......220--......------.230.......240.......250.......260.......270.......280....-....290.......300.......310.......320.......330....-...340.......350.......360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
R
W
I
TAGESH
G
R
A
L
V
A
V
V
E
G
M
VAG
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
RLGYGRGA
R
M
T
F-----
E
R
D
A
V
T
V
L
S
G
IRHGSTLG
G
P
I
A
I
E
IGNTEW-P-KW
E
T
V
M
AADPV
D
P
A
E
L
A
D
V
-
A
RNAPLTRPRPGHA
D
Y
A
G
M
L
KYGFD
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
IGA-SAPYE-GPPPR-A-ED---L------PAIDA----S
P
V
R
A
Y
D
KAA
E
A
D
M
I
A
Q
I
E
AAKKDGD
T
L
G
G
V
--
V
E
A
V
A
L------GLPVGLGSFTSG
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
IK
G
V
EIG
D
G
F
Q
T
A
R
RRGSRAHDE-MYPGP-DG
V
V
RSTNRAGGLEGGMTNGQ
P
L
R
V
R
AAMK
P
I
S
T
VPR
A
L
A
T
V
DLATGD
E
A
V
-
A
I
HQRSDVCAVPA
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
KFGG
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
VADREAPAARVSG
4
PsiBlast_PDB
97.15
100%
-97
- C5 -
2O12
7
AROC_MYCTU
A:
[1-392]
M
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
R
-----------
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
E
L
A
D
V
-
A
R
N
A
P
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
-
G
P
P
P
R
-
A
-
E
D
---
L
------
P
A
I
D
A
----
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
--
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
-
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
---------
5
PsiBlast_PDB
96.79
100%
-93
- C5 -
2QHF
17
AROC_MYCTU
A:
[1-392]
M
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
R
G
A
R
M
T
F
-----
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
E
L
A
D
V
-
A
R
N
A
P
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
-
G
P
P
P
R
-
A
-
E
D
---
L
------
P
A
I
D
A
----
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
--
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
-
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
---------
25
HHSearch
96.75
100%
-98
- C5 -
2O11
7
AROC_MYCTU
A:
[1-392]
M
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
--------------
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
E
L
A
D
V
-
A
R
N
A
P
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
-
G
P
P
P
R
-
A
-
E
D
---
L
------
P
A
I
D
A
----
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
--
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
-
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
---------
3
PsiBlast_PDB
96.75
100%
-98
- C5 -
2O11
7
AROC_MYCTU
A:
[1-392]
M
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
--------------
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
E
L
A
D
V
-
A
R
N
A
P
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
-
G
P
P
P
R
-
A
-
E
D
---
L
------
P
A
I
D
A
----
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
--
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
-
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
---------
1
PsiBlast_PDB
96.50
100%
-90
- C5 -
1ZTB
-
AROC_MYCTU
A:
[1-392]
M
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
R
G
A
---------
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
E
L
A
D
V
-
A
R
N
A
P
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
-
G
P
P
P
R
-
A
-
E
D
---
L
------
P
A
I
D
A
----
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
--
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
-
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
---------
2
PsiBlast_PDB
96.46
100%
-97
- C5 -
2G85
-
AROC_MYCTU
A:
[1-392]
M
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
------
F
-----
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
E
L
A
D
V
-
A
R
N
A
P
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
-
G
P
P
P
R
-
A
-
E
D
---
L
------
P
A
I
D
A
----
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
--
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
-
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
---------
7
PsiBlast_PDB
95.25
97%
-99
- C5 -
4BAJ
2
AROC_MYCTU
A:
[2-392]
-
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
----------------
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
E
L
A
D
V
-
A
R
N
A
P
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
-
G
P
P
P
R
-
A
-
E
D
---
L
------
P
A
I
D
A
----
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
--
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
-
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
-----
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
---------
6
PsiBlast_PDB
95.20
97%
-100
- C5 -
4BAI
2
AROC_MYCTU
A:
[2-392]
-
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
----------------
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
E
L
A
D
V
-
A
R
N
A
P
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
-
G
P
P
P
R
-
A
-
E
D
---
L
------
P
A
I
D
A
----
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
--
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
-
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
----
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
---------
26
HHSearch
77.53
45%
-80
- C5 -
1QXO
9
AROC_STRPN
A:
[1-388]
-
M
R
Y
L
T
A
G
E
S
H
G
P
R
L
T
A
I
I
E
G
I
P
A
G
L
P
L
T
A
E
D
I
N
E
D
L
R
R
R
Q
G
G
Y
G
R
G
G
R
M
K
I
-----
E
N
D
Q
V
V
F
T
S
G
V
R
H
G
K
T
T
G
A
P
I
T
M
D
V
I
N
K
D
H
-
Q
-
K
W
L
D
I
M
S
-----
A
E
D
I
E
D
R
L
K
S
K
R
K
I
T
H
P
R
P
G
H
A
D
L
V
G
G
I
K
Y
R
F
D
D
L
R
N
S
L
E
R
S
S
A
R
E
T
T
M
R
V
A
V
G
A
V
A
K
R
L
L
A
E
-
L
D
M
E
I
A
N
H
V
V
V
F
G
G
-
K
E
I
D
V
-
P
E
N
L
T
-
V
A
E
I
---
K
------
Q
R
A
A
Q
----
S
E
V
S
I
V
N
Q
E
R
E
Q
E
I
K
D
Y
I
D
Q
I
K
R
D
G
D
T
I
G
G
V
--
V
E
T
V
V
G
------
G
V
P
V
G
L
G
S
Y
V
Q
W
D
R
K
L
D
A
R
L
A
Q
A
V
V
S
I
N
A
F
K
G
V
E
F
G
L
G
F
E
A
G
Y
R
K
G
S
Q
V
M
D
E
-
I
L
W
S
K
E
D
G
Y
T
R
R
T
N
N
L
G
G
F
E
G
G
M
T
N
G
Q
P
I
V
V
R
G
V
M
K
P
I
P
T
L
Y
K
P
L
M
S
V
D
I
E
T
H
E
P
Y
K
-
A
T
V
E
R
S
D
P
T
A
L
P
A
A
G
M
V
M
E
A
V
V
A
T
V
L
A
Q
E
I
L
E
K
F
S
S
D
N
L
E
E
L
K
E
A
V
A
K
H
R
D
Y
T
K
N
Y
---------
8
PsiBlast_PDB
77.12
44%
-82
- C5 -
1QXO
8
AROC_STRPN
A:
[2-382]
--
R
Y
L
T
A
G
E
S
H
G
P
R
L
T
A
I
I
E
G
I
P
A
G
L
P
L
T
A
E
D
I
N
E
D
L
R
R
R
Q
G
G
Y
G
R
G
G
R
M
K
I
-----
E
N
D
Q
V
V
F
T
S
G
V
R
H
G
K
T
T
G
A
P
I
T
M
D
V
I
N
K
D
H
-
Q
-
K
W
L
D
I
M
S
A
E
D
I
E
D
R
----
L
-
K
S
K
R
K
I
T
H
P
R
P
G
H
A
D
L
V
G
G
I
K
Y
R
F
D
D
L
R
N
S
L
E
R
S
S
A
R
E
T
T
M
R
V
A
V
G
A
V
A
K
R
L
L
A
E
-
L
D
M
E
I
A
N
H
V
V
V
F
G
G
-
K
---
E
-
I
D
V
P
E
-
N
-
L
T
---
V
------
A
E
I
K
Q
R
A
A
Q
S
E
V
S
I
V
N
Q
E
R
E
Q
E
I
K
D
Y
I
D
Q
I
K
R
D
G
D
T
I
G
G
V
--
V
E
T
V
V
G
------
G
V
P
V
G
L
G
S
Y
V
Q
W
D
R
K
L
D
A
R
L
A
Q
A
V
V
S
I
N
A
F
K
G
V
E
F
G
L
G
F
E
A
G
Y
R
K
G
S
Q
V
M
D
E
I
L
W
S
K
E
-
D
G
Y
T
R
R
T
N
N
L
G
G
F
E
G
G
M
T
N
G
Q
P
I
V
V
R
G
V
M
K
P
I
P
T
L
Y
K
P
L
M
S
V
D
I
E
T
H
E
P
Y
K
-
A
T
V
E
R
S
D
P
T
A
L
P
A
A
G
M
V
M
E
A
V
V
A
T
V
L
A
Q
E
I
L
E
K
F
S
S
D
N
L
E
E
L
K
E
A
V
A
K
H
R
---------------
32
HHSearch
72.69
34%
-83
- C5 -
1UM0
2
AROC_HELPY
A:
[7-357]
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
-----
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
R
S
K
D
Y
D
-
N
I
-------------------
K
N
L
F
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
-
I
K
A
K
N
-
Y
D
-----------
F
------
N
H
A
L
K
----
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
--
A
L
I
R
A
R
S
IKTNQ
K
L
P
I
G
L
G
--
Q
G
L
Y
A
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
-
M
D
Q
-----
K
G
F
L
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
-
G
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
K
I
E
Y
-------------------------
23
PsiBlast_CBE
71.74
32%
-79
- C5 -
1UM0
2
AROC_HELPY
C:
[7-348]
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
-----
Q
G
G
R
N
V
F
ITPRK
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
-----------
A
R
S
K
D
Y
D
N
I
K
N
L
-
F
--------
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
--------
G
I
K
A
K
-
N
-
Y
D
---
F
------
N
H
A
L
K
----
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
AL
I
R
A
R
S
I
KTNQ--
K
L
P
I
G
L
G
Q
G
L
Y
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
-
M
-----
D
Q
K
G
F
L
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
-
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
----------------------------------
24
PsiBlast_CBE
71.54
32%
-81
- C5 -
1UM0
2
AROC_HELPY
B:
[7-348]
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
-----
Q
G
G
R
N
V
F
ITPRK
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
-----------
A
R
S
K
D
Y
D
N
I
K
N
L
-
F
--------
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
--------
G
I
K
A
K
-
N
-
Y
D
---
F
------
N
H
A
L
K
----
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
AL
I
R
A
R
S
I
KTNQ--
K
L
P
I
G
L
G
Q
G
L
Y
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
-
M
-----
D
Q
K
G
F
L
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
-
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
----------------------------------
13
PsiBlast_PDB
71.15
32%
-77
- C5 -
1UM0
2
AROC_HELPY
A:
[7-348]
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
-----
Q
G
G
R
N
V
F
ITPRK
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
-----------
A
R
S
K
D
Y
D
N
I
K
N
L
-
F
--------
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
--------
G
I
K
A
K
-
N
-
Y
D
---
F
------
N
H
A
L
K
----
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
I
KTNQ--
K
L
P
I
G
L
G
Q
G
L
Y
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
-
M
-----
D
Q
K
G
F
L
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
-
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
----------------------------------
14
PsiBlast_PDB
71.03
32%
-76
- C5 -
1UMF
-
AROC_HELPY
A:
[7-348]
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
-----
Q
G
G
R
N
V
F
ITPRK
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
-----------
A
R
S
K
D
Y
D
N
I
K
N
L
-
F
--------
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
--------
G
I
K
A
K
-
N
-
Y
D
---
F
------
N
H
A
L
K
----
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
I
KTNQ--
K
L
P
I
G
L
G
Q
G
L
Y
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
-
M
-----
D
Q
K
G
F
L
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
-
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
----------------------------------
22
PsiBlast_CBE
71.01
32%
-75
- C5 -
1UM0
2
AROC_HELPY
D:
[7-348]
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
-----
Q
G
G
R
N
V
F
ITPRK
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
-----------
A
R
S
K
D
Y
D
N
I
K
N
L
-
F
--------
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
--------
G
I
K
A
K
-
N
-
Y
D
---
F
------
N
H
A
L
K
----
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
AL
I
R
A
R
S
I
KTNQ--
K
L
P
I
G
L
G
Q
G
L
Y
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
-
M
-----
D
Q
K
G
F
L
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
-
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
----------------------------------
30
HHSearch
68.32
36%
-101
- C5 -
4OB9
-
?
A:
[9-354]
L
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
-----
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
K--------------------------------------------------
G
G
-
G
R
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
N
-
E
V
A
E
K
-
L
--------
D
---
W
------
N
E
V
P
N
----
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
--
L
E
I
L
A
E
------
K
V
P
V
G
W
G
--
E
P
V
F
D
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
-
L
T
S
H
-----
G
F
L
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
A
---------------------
K
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
N
A
D
V
-------------------------
10
PsiBlast_PDB
66.81
35%
-97
- C5 -
4LJ2
-
?
A:
[9-340]
L
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
-----
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
-
K
-
S
------------
K
------------------------------
R
D
Y
R
G
G
-
G
R
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
N
-
E
V
-------
A
E
-
K
-
L
D
---
W
------
N
E
V
P
N
----
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
--
L
E
I
L
A
E
------
K
V
P
V
G
W
G
E
P
V
F
--
D
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
-
L
T
--
S
-
H
G
F
L
--
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
A
S
I
T
------------------
K
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
---------------------------------------
29
HHSearch
66.65
36%
-101
- C5 -
1R53
-
AROC_YEAST
A:
[7-371]
L
F
R
V
T
T
Y
G
E
S
H
C
K
S
V
G
C
I
V
D
G
V
P
P
G
M
S
L
T
E
A
D
I
Q
P
Q
L
T
R
R
R
P
-----------------
D
R
V
E
I
Q
S
G
T
E
F
G
K
T
L
G
T
P
I
A
M
M
I
K
N
--------------------------------------------------------------
R
E
T
I
G
R
V
A
S
G
A
I
A
E
K
F
L
A
Q
N
S
N
V
E
I
V
A
F
V
T
Q
I
G
E
-
I
K
M
N
R
D
S
F
D
P
E
F
Q
-
H
L
L
N
T
I
T
R
E
---
K
V
D
S
M
----
G
P
I
R
C
P
D
A
S
V
A
G
L
M
V
K
E
I
E
K
Y
R
G
N
K
D
S
I
G
G
V
--
V
T
C
V
V
R
------
N
L
P
T
G
L
G
--
E
P
C
F
D
K
L
E
A
M
L
A
H
A
M
L
S
I
P
A
S
K
G
F
E
I
G
S
G
F
Q
G
V
S
V
P
G
S
K
H
N
D
P
-
F
Y
-------
R
T
K
T
N
N
S
G
G
V
Q
G
G
I
S
N
G
E
N
I
Y
F
S
V
P
F
K
S
V
------------------------
R
H
D
P
A
V
T
P
R
A
I
P
I
V
E
A
M
T
A
L
V
L
A
D
A
L
L
I
Q
K
A
R
D
F
S
--------------------------
9
PsiBlast_PDB
66.57
34%
-108
- C5 -
1R53
-
AROC_YEAST
A:
[7-363]
L
F
R
V
T
T
Y
G
E
S
H
C
K
S
V
G
C
I
V
D
G
V
P
P
G
M
S
L
T
E
A
D
I
Q
P
Q
L
T
R
R
R
P
-----------------
D
R
V
E
I
Q
S
G
T
E
F
G
K
T
L
G
T
P
I
A
M
M
I
K
N
--------------------------------------------------------------
R
E
T
I
G
R
V
A
S
G
A
I
A
E
K
F
L
A
Q
N
S
N
V
E
I
V
A
F
V
T
Q
I
G
E
I
K
M
N
R
D
-
S
F
D
P
E
-
F
-
Q
H
---
L
L
N
TIT
R
E
K
V
D
S
M
---
G
P
I
R
C
P
D
A
S
V
A
G
L
M
V
K
E
I
E
K
Y
R
G
N
K
D
S
I
G
G
V
--
V
T
C
V
V
R
------
N
L
P
T
G
L
G
E
--
P
C
F
D
K
L
E
A
M
L
A
H
A
M
L
S
I
P
A
S
K
G
F
E
I
G
S
G
F
Q
G
V
S
V
P
G
S
K
H
N
D
P
-
F
Y
-------
R
T
K
T
N
N
S
G
G
V
Q
G
G
I
S
N
G
E
N
I
Y
F
S
V
P
F
K
S
V
------------------------
R
H
D
P
A
V
T
P
R
A
I
P
I
V
E
A
M
T
A
L
V
L
A
D
A
L
L
----------------------------------