@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0007: (2015-12-17 )
MKRLKKTLHLSSLSLASLALSSAALAAAPVMLDQGKEWTESHRQDFYSRDQGSQVMPLPWLKALRQPDGTPFLADSLARYGYLPNPKAPAEGLPVGFTVAGTGARQMVGMTCSACHTRQIEVKGTAYRIDGGPAIVDFQAFLADLDRAVGPLTSDDAAFDAFAKPILGANPPPGARDALLAAVKEWYEPYHTLIERALPKDTWGPARLDAVSMIFNRLTGLDIGTAPPYLIPDNIKAADAPVRYPFLWNAARQNKTQWPGFAANGNDLLGLARNVGEVYGVFATFHPQKSKFHLLGMDYLKINSANFHGLGKLEDLIKKIGPPKWPWAVDKHLARKGALIFARKTDEGGCVECHGIRIKDLVLWDTPLRDVGSDSRQHAILDGQVQTGVMEGARMPFGQPLKATDGAFDVLAVAVAGSILQHFVPILGEKHDAKAAAVKPESVMTDETRQLLTAFQKPVRTQADPYPYESRVLQGIWAAAPYLHNGSVPTLEELLKPAAERVESFPVGSAYDVDKVGLAAQQTQFGSYVLKTTGCEQRDSGNSRCGHEYGTSLSAEEKRALLEYLKVL
Atome Classification :
(20 SA)
.........10........20........30........40........----50........60........70........80.-.......90........100.......110.......120.......130.......140.-......150.......160-........170.......180-------..---------..---..-..190.......200.....--..210....------------...220.......230.--......240.......250.------------..----------....260.....--..270.......280..-..-----.------.-------.-..290.....--..300.------..-.-...-310.......--320--......--------.330.......340..--------------.-....350....---------------...360..------.....370.......380.......390.......400.......410.......420..-.....430.......440........450.....---..460.......470------.......480---.........490.......500......-.510--.........520.......530.......540....-...550.......560......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
R
L
K
K
T
L
H
LS
S
L
S
L
A
S
L
A
L
S
S
A
A
L
A
AA
P
V
MLDQG
K
E
W
T
E
S
H
R
Q
D
F
YSR----DQGSQVMP
L
P
W
L
K
A
LRQPDGT
P
F
L
A
D
S
L
A
RYGY-LPNPKAPAEGLP
V
G
F
T
V
AGTGA
R
Q
M
V
G
M
T
CSAC
H
T
R
Q
I
E
V
KG
T
A
Y
R
IDGG
P
A
I
V
D
F
Q
A
F
L
A
-
D
L
D
R
AVGPLTSD
D
A
A
F
D
A
--
F
A
K
P
I
LGANPPP
G
A
R
D
A
L
L
A
--------
A
V
---------
K
E
---
W
Y
-
E
P
Y
H
T
L
I
E
R
ALPKDTWG
P
A
R
--
L
D
A
V
S
M
I
F
N
------------
R
LTGLDIGTAPPYLIPD--NIKAADAPVRY
P
F
LWNAARQ------------NK----------TQWPGFAANG
N
D
--
L
L
G
L
A
R
N
V
G
E
V
Y
G
--
V
F
-
A
T-----F------H-------P-QK
S
K
F
H
L
L
G
M
--
D
Y
L
K
IN------SA-N-FHG-
L
G
K
L
E
D
L
I
K
K--IGP--PKWP
W
A
--------
V
D
K
H
L
ARK
G
A
L
I
F
A
R
K--------------T-DEGG
C
V
E
C
H
G
I
---------------
R
I
K
D
L
V
LW------DT
P
L
R
DVGSDSR
Q
H
A
I
LDGQ
V
Q
T
G
V
MEGARMPFGQPLKATDG
A
F
D
V
L
A
V
A
V
A
G
S
I
L
Q
H
F
V
-
P
I
LGEKHDAKAAAVKP-ESVM
T
D
E
T
R
Q
L
L
T
A
F
Q
K
---PVRTQADPY
P
Y
E
S
R
V
------
L
Q
G
I
W
A
AA-----PYLHNGS
V
P
T
L
E
E
L
L
K
P
A
A
E
R
V
E
SFPVG-SA----YD
V
D
KVGL
A
A
Q
QTQFG
S
Y
V
L
KTTGCEQRDSGNSRCG-HEYGTSL
S
A
E
E
K
R
A
L
L
E
Y
L
K
VL-
51
Fugue
80.53
13%
-33
- C2 -
2BVL
8
TOXB_PEPDI
A:
[1-543]
-
M
S
L
V
N
R
K
Q
L
E
K
M
A
N
V
R
F
R
T
Q
E
D
E
Y
V
A
I
L
D
A
L
E
E
Y
H
N
M
S
E
N
T
V
V
E
K
Y
L
K
L
K
D
I
N
S
L
T
D
I
C
I
D
T
Y
K
K
S
G
R
N
K
A
L
K
K
F
K
E
Y
L
V
T
E
V
L
E
-
L
K
N
N
N
L
T
P
V
E
K
N
L
H
F
V
W
I
G
G
Q
I
N
-----
D
T
A
I
N
Y
I
N
Q
W
K
D
V
N
S
D
Y
N
V
N
---
V
F
Y
D
S
N
A
F
L
I
-
N
T
L
K
K
T
V
V
E
S
A
I
N
D
T
L
E
S
--
F
R
E
N
L
--
N
D
P
R
F
D
Y
N
K
F
F
R
K
--------
R
M
---------
E
I
---
I
Y
-
D
K
Q
K
N
F
I
N
Y
Y
K
A
Q
R
E
E
N
P
E
L
I
I
D
D
I
V
K
T
Y
L
S
------------
N
E
Y
S
K
E
I
D
E
L
N
T
Y
I
E
E
S
--
L
N
K
I
T
Q
N
S
G
N
D
V
R
N
F
G
E
F
K
N
------------
G
E
S
F
N
L
Y
E
Q
E
L
V
E
R
W
N
L
A
A
A
S
D
I
L
--
R
I
S
A
L
K
E
I
G
G
M
Y
---
L
D
-
V
D
-----
M
------
L
-------
P
-
G
I
Q
P
D
L
F
E
S
I
--
E
K
P
S
S
V
------
T
V
-
D
-
F
W
E
-
M
T
K
L
E
A
I
M
K
Y
--
K
E
Y
I-
P
E
Y
T
S
E
--------
H
F
D
M
L
D
E
E
V
Q
S
S
F
E
S
V
--------------
L
-
A
-----------------------------------------------
S
K
S
D
K
S
E
I
F
S
---
S
L
G
D
M
E
A
S
P
L
E
V
-
K
I
A
F
N
S
K
G
I
I
N
Q
G
L
I
S
V
K
D
S
Y
C
S
N
L
I
V
K
Q
I
E
N
R
Y
K
I
L
N
N
S
L
N
P
-
A
I
S
E
D
N
D
F
N
T
T
T
N
T
F
I
D
---
S
I
M
A
E
A
N
A
D
N
--
G
R
F
------
M
M
E
L
G
K
Y
L
RVGFF
P
D
V
K
T
T
I
N
L
S
G
P
E
A
Y
A
A
A
Y
Q
D
L
L
M
F
K
E
G
-
S
M
NIHL
I
E
A
D
L
R
N
F
E
I
S
K
T
N
----
I
S
Q
S
T
E
Q
E
M
----
A
S
L
W
S
-
F
D
D
A
R
A
K
A
Q
F
E
E
Y
K
R
N
Y
F
E
G
A
L
-
52
Fugue
72.87
18%
-26
- C2 -
4FDT
2
?
A:
[21-425]
------------------------------------------
M
Q
T
K
I
Q
K
----
Y
A
G
T
A
-
M
P
Y
P
N
----
R
T
D
G
M
T
P
F
Y
I
N
H
L
G
R
H
G
A
R
F
P
T
S
R
K
A
L
D
K
V
E
K
V
L
V
S
A
Q
Q
E
N
----
G
L
T
-----------------
S
E
G
M
A
L
L
S
M
I
R
R
L
S
R
-
L
F
D
G
Q
W
G
K
L
S
--------------
K
L
G
E
T
E
Q
E
G
I
A
G
R
M
I
R
--------
N
Y
---------
P
Q
---
L
F
-
S
N
S
A
K
I
E
A
I
A
----
T
Y
V
P
R
S
--
I
N
S
M
D
A
F
L
S
------------
C
M
I
R
H
--------------------------------------------------------------------
N
P
--
A
L
Q
V
Q
R
S
E
G
K
Q
Y
N
--
H
I
-
L
R
-----
F
------
F
-------
D
-
L
N
K
S
Y
V
N
Y
K
E
KG
D
W
L
P
I
Y
------
K
A
-
F
-
V
H
K
-
K
I
S
P
V
P
I
M
K
K
F
L
L
N
P
--
E
Q
Y
L
D
K
--------
E
A
E
E
F
V
M
A
L
F
S
V
A
A
I
L
--------------
P
-
D
T
S
I
------------------------------------
P
L
N
L
E
D
L
F
T
L
D
E
W
H
R
Y
W
Q
T
Q
N
L
R
Q
Y
M
S
K
S
S
A
P
V
G
K
----------
M
L
P
V
A
I
A
W
P
L
L
S
E
F
I
-
R
S
A
Q
E
V
I
S
G
K
S
D
Y
Q
A
N
-
F
R
F
A
H
A
E
T
V
I
P
F
V
S
L
M
G
---
I
E
K
T
--
D
V
Q
V
C
R
P
D
S
------
V
S
V
Y
W
K
------------------
D
Y
E
I
S
P
M
A
A
N
V
Q
W
L
F
Y
R
-
D
R
----
D
Q
--
R
I
W
V
K
I
L
L
N
E
E
A
A
A
L
P
I
S
T
A
C
F
P
Y
Y
S
-------
W
E
K
T
R
I
F
F
N
Q
R
I
E
M
A
K
K
T
L
S
V
F
N
31
HHSearch
68.71
21%
-35
- C4 -
3O5C
3
?
A:
[72-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
I
N
S
P
T
V
L
N
A
D
F
M
------------
L
A
----------
Q
F
W
D
G
R
A
S
N
L
K
-------
E
Q
A
A
G
P
I
A
N
PK
E
M
-
G
F
-----
T
H
E
L
A
T
E
T
-------
I
-
A
S
M
P
A
Y
R
A
R
F
--
A
K
V
Y
G
D
E-----
K
V
D
I
-
D
R
L
-
T
D
A
I
A
A
F
E
K
T
--
L
V
T
--
P
N
S
P
F
D
Q
Y
L
L
GKQD
A
I
S
G
D
A
K
A
G
Y
Q
L
F
K
D
-------------------
K
G
C
V
S
C
H
N
G
---------------
P
A
V
--
G
--------
G
T
M
F
M
K
M
G
L
I
K
P
F
-
H
T
N
--
N
P
--------------------------------------------------
A
E
G
R
------------
K
G
V
T
G
K
-------
D
--
A
D
K
F
V
F
K
V
P
T
------
L
R
N
I
E
L
T
Y
-----
P
Y
F
H
D
G
S
V
W
T
L
E
E
A
V
N
--------
T
M
A
-----------------------------
D
-----
I
Q
----------
L
G
Q
K
L
T
E
K
E
T
K
E
M
V
A
F
L
N
S
L
-
53
Fugue
67.82
13%
-19
- C2 -
4DGK
6
CRTI_PANAN
A:
[1-492]
M
K
P
-----------
T
T
V
I
G
A
G
F
G
G
L
A
L
A
I
R
L
Q
A
A
G
I
P
V
L
L
L
E
Q
R
Y
V
Y
E
D
----
Q
G
----------------------------------------------------------------------------
F
T
F
D
A
G
P
T
V
I
T
D
P
S
A
I
E
-
E
L
F
A
L
A
G
K
Q
L
K
E
Y
V
---------
E
L
L
P
V
T
P
F
-------------------------------------------------------------
Y
R
L
C
W
E
------------
S
G
K
V
F
N
Y
D
N
D
Q
T
R
L
E
A
Q
I
Q
Q
F
N
P
R
D
V
E
G
Y
R
Q
F
L
D
Y
S
R
A
V
------------
F
K
----------
E
G
Y
L
G
T
V
P
F
----------
L
S
F
R
D
M
L
R
--
A
A
-
P
Q
-----
L
------
A
-------
K
-
L
Q
A
W
R
S
V
Y
S
K
--
V
A
S
Y
I
E
------
D
E
-
H
-
L
R
Q
-
A
F
S
F
H
S
L
L
V
G
--
G
N
P
--
T
S
S
I
Y
T
--------
L
I
H
A
L
E
R
E
W
G
V
W
F
P
R
-------------------
G
G
T
G
A
L
V
Q
G
---------------
M
I
K
L
F
Q
D
L
------
G
G
E
V
V
------
L
N
A
R
V
S
H
M
E
T
T
G
N
K
I
E
A
V
H
L
E
D
G
R
R
F
L
T
Q
-------
A
V
A
S
N
A
D
S
N
S
L
F
V
-
L
Y
F
G
L
N
H
H
H
D
Q
L
A
H
H
T
-
V
C
F
G
P
R
L
A
E
D
F
S
L
Y
L
H
A
---
P
C
V
T
D
S
S
L
A
P
E
G
C
---------
G
S
Y
Y
V
L
A
-----
P
V
------
P
H
L
G
T
A
N
L
D
W
T
V
E
G
P
K
L
R
D
R
-
I
F
----
A
Y
L
E
Q
H
Y
M
P
G
L
R
S
Q
L
V
T
H
R
M
F
T
P
F
D
F
R
T
I
T
N
L
Y
L
V
G
-
A
G
I
P
G
V
I
G
S
A
K
A
T
A
G
L
M
L
E
D
L
I
-
32
HHSearch
65.21
18%
-34
- C4 -
1ZZH
5
?
A:
[79-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
R
N
A
P
T
A
L
N
A
V
F
N
------------
V
A
----------
Q
F
W
D
G
R
A
P
D
L
A
A
Q
A---------
M
-
N
N
--
T
P
E
N
L
-----
V
------
A
T
------
V
-
Q
S
M
P
G
Y
V
E
A
F
--
A
K
A
F
P
G
QKD---
P
I
-
S
-
F
D
N
F
A
L
A
V
E
A
F
E
A
T
--
L
I
T
--
P
N
S
K
F
D
Q
W
L
M
GADG
A
M
S
A
D
E
K
A
G
L
K
L
F
I
D
-------------------
T
G
C
A
A
C
H
N
G
---------------
I
N
I
--
G
G
--------
N
G
Y
Y
P
F
G
V
V
E
K
P
------------------------------------------------------------
G
R
F
------------
A
V
T
A
T
-------
A
--
D
D
E
Y
V
F
R
A
G
P
------
L
R
N
I
A
L
T
A
-----
P
Y
F
H
S
G
K
V
W
D
L
R
E
A
V
S
--------
V
M
A
N
----------------------------------
S
Q
L
----------
G
A
T
L
D
D
T
Q
V
D
Q
I
T
A
F
L
G
T
L
-
28
HHSearch
64.57
18%
-28
- C4 -
2VHD
3
CCPR_PSEAE
A:
[76-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
R
N
S
P
T
V
F
N
A
V
F
N
------------
A
A
----------
Q
F
W
D
G
R
A
K
D
L
G
-------
E
Q
A
K
G
P
I
Q
N
SV
E
M
-
H
S
T
P
Q
L
V
E
Q
-----
T
-------
L
-
G
S
I
P
E
Y
V
D
A
F
--
R
K
A
F
P
K
AGK---
P
V
-
S
F
D
N
M
-
A
L
A
I
E
A
Y
E
A
T
--
L
V
T
--
P
D
S
P
F
D
L
Y
L
K
GDDK
A
L
D
A
Q
Q
K
K
G
L
K
A
F
M
D
-------------------
S
G
C
S
A
C
H
N
G
---------------
I
N
L
--
G
G
--------
Q
A
Y
F
P
F
G
L
V
K
K
P
--------
D
A
S
V
L
P
S
------------------------------------------
G
D
K
G
R
F
------------
A
V
T
K
--------
T
-
Q
S
D
E
Y
V
F
R
A
A
P
------
L
R
N
V
A
L
T
A
-----
P
Y
F
H
S
G
Q
V
W
E
L
K
D
A
V
A
--------
I
M
G
N
----------------------------------
A
Q
----------
L
G
K
Q
L
A
P
D
D
V
E
N
I
V
A
F
L
H
S
L
-
27
HHSearch
58.42
16%
-14
* C4 *
3SJL
6
MAUG_PARDP
A:
[63-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
R
N
T
P
T
L
G
Y
A
A
L
V
PA
F
H
R
D
ANG
K
Y
K
G
G
----------
Q
F
W
D
G
R
A
D
D
L
K
-------
Q
Q
A
G
Q
S
M
L
N
PV
E
M
-
A
M
-----
P
------
D
R
A
A
V
A
A
R
L
-
R
D
D
P
A
Y
R
T
G
F
--
E
A
L
F
G
K
GVLDD
P
E
R
A
F
-
D
A
A
-
A
E
A
L
A
A
Y
Q
A
T
--
G
E
F
SP
F
D
S
K
Y
D
R
V
M
R
GE
E
-
K
F
T
P
L
E
E
F
G
Y
T
V
F
I
T
-------------------
W
N
C
R
L
C
H
M
Q
---------------
R
K
Q
--
G
V
A
ERETFT
N
F
E
Y
H
N
I
G
L
P
V
N
E
T
A
R
E
A
----
S
G
-
L
-
G
A
D
---------------------------------------
H
V
D
H
G
L
L
------------
A
R
P
G
I
E
------
D
-
P
A
Q
S
G
R
F
K
V
P
S
------
L
R
N
V
A
V
T
G
-----
P
Y
M
H
N
G
V
F
T
D
L
R
T
A
I
L
--------
F
Y
N
K
Y
T
S
----
R
R
P
E
-
A
K
I
N
P
E
T
--
G
-
A
P
W
G
E
P
-----
E
V
A
R
N
L
S
L
A
E
L
Q
S
G
L
M
L
D
D
G
R
V
D
A
L
V
A
F
L
E
T
L
-
33
HHSearch
56.30
17%
-36
- C4 -
1IQC
5
CCPR_NITEU
A:
[64-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
I
N
A
P
T
V
L
N
S
S
M
N
------------
L
A
----------
Q
F
W
D
G
R
A
K
D
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
A
S
T
--
H
E
-
I
A
-----
E
------
K
-------
V
V
A
S
M
P
Q
Y
R
E
R
F
--
K
K
V
F
G
S
D-----
E
V
-
T
I
D
R
I
-
T
T
A
I
A
Q
F
E
E
T
--
L
V
T
--
P
G
S
K
F
D
K
W
L
E
GDKN
A
L
N
Q
D
E
L
E
G
Y
N
L
F
K
G
-------------------
S
G
C
V
Q
C
H
N
G
---------------
P
A
V
--
G
G
S
--------
S
Y
Q
K
M
G
V
F
K
P
----
Y
--
E
-------
T
K
N
----------------------------------------
P
A
A
G
R
------------
M
D
V
T
G
--------
N
E
-
A
D
R
N
V
F
K
V
P
T
------
L
R
N
I
E
L
T
Y
-----
P
Y
F
H
D
G
G
A
A
T
L
E
Q
A
V
E
--------
T
M
G
R
----------------------------------
I
Q
----------
L
N
R
E
F
N
K
D
E
V
S
K
I
V
A
F
L
K
T
L
-
4
PsiBlast_PDB
50.25
26%
-41
- C3 -
1M9I
2
ANXA6_HUMAN
A:
[363-503]
-----------------------------------------------------------------------------------------
N
P
D
A
D
A
K
A
L
R
K
A
M
K
G
L
G
T
D
E
D
T
I
I
D
I
I
T
H
R
S
N
V
Q
R
Q
Q
I
R
Q
T
F
K
S
H
F
G
R
D
L
M
T
D
L
K
S
E
I
S
G
D
L
A
R
L
I
L
G
L
M
M
P
P
A
H
Y
D
A
K
Q
L
K
K
A
M
E
G
A
G
T
D
E
K
A
L
I
E
I
L
A
T
RT
N
A
E
I
R
A
I
---------
N
E
---
A
Y
K
E
D
Y
H
K
S
L
E
D
A
L
S
S
D
T
S
G
H
F
R
--
R
I
L
I
S
L
A
T
G
------------
H
R
E
E
G
G
E
N
L
D
Q
A
R
E
D
A
Q
--
V
A
A
E
I
L
E
I
A
D
T
P
S
G
D
K
T
S
L
E
------------
T
R
----------
F
M
T
I
L
C
T
R
S
Y
P
H
--
L
R
R
V
F
Q
E
F
I
K
M
T
N
--
Y
D
-
V
E
-----
H
------
T
-------
I
-
K
K
E
M
S
G
D
V
R
D
--
A
F
V
A
I
V
------
Q
S
-
V
-
K
N
K
-
P
L
F
F
A
D
K
L
Y
K
--
S
M
K
--
G
A
G
T
D
D
--------
K
T
L
T
R
I
M
V
S
R
S
E
I
D
L
L
--------------
N
-
I
R
R
E
F
I
E
K
Y
D
K
---------------
S
L
H
Q
A
I
E
G
------
D
T
S
G
D
F
L
K
A
L
L
A
L
C
G
G
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
47.55
24%
-34
- C3 -
1AVC
2
ANXA6_BOVIN
A:
[364-504]
-----------------------------------------------------------------------------------------
N
P
D
A
D
A
K
A
L
R
K
A
M
K
G
L
G
T
D
E
D
T
I
I
D
I
I
T
H
R
S
N
A
Q
R
Q
Q
I
R
Q
T
F
K
S
H
F
G
R
D
L
M
A
D
L
K
S
E
L
S
G
D
L
A
R
L
I
L
G
L
M
M
P
P
A
H
Y
D
A
K
Q
L
K
K
A
M
E
G
A
G
T
D
E
K
A
L
I
E
I
L
A
--------
T
R
T
N
A
E
I
Q
A
I
N
K
A
---
Y
K
-
E
D
Y
H
K
T
L
E
D
A
L
S
S
D
T
S
G
H
F
K
--
R
I
L
I
S
L
A
T
G
------------
N
R
E
E
G
G
E
D
R
E
R
A
R
E
D
A
Q
--
V
A
A
E
I
L
T
R
F
M
M
I
L
C
T
R
S
Y
P
D
------------
L
R
----------
R
V
F
Q
E
F
V
K
M
T
N
Y
--
D
V
E
H
T
I
K
K
E
M
S
G
D
--
V
R
-
D
V
-----
F
------
V
-------
A
-
I
V
Q
S
V
K
N
K
P
L
--
F
F
A
D
K
L
------
Y
K
-
S
-
M
K
G
-
A
G
T
E
E
K
T
L
T
R
--
I
M
V
--
S
R
S
E
I
D
--------
L
L
N
I
R
R
E
F
I
E
K
Y
D
K
S
L
--------------
H
-
Q
A
I
E
G
D
T
S
G
H
F
---------------
L
K
A
L
L
A
I
C
------
G
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
47.00
20%
-21
- C3 -
4B2N
2
?
A:
[339-531]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
N
F
L
I
S
--
L
S
P
--
A
T
Y
P
K
T
--------
I
N
T
A
L
A
E
Q
G
A
V
I
Y
H
E
R
DLWASGANGAIPKP
A
-
G
N
G
S
C
A
S
C
H
G
V
YS
P
R
H
A
A
DPNYLPDP
R
L
K
G
V
A
A
V
------
V
T
P
I
E
T
I
R
T
D
P
R
R
M
R
L
M
A
D
E
R
Q
R
R
A
W
N
S
G
W
W
-----------
A
Y
N
N
L
S
P
S
W
T
G
---------------------
Y
P
S
-
D
N
I
V
A
S
E
L
R
R
V
P
R
A
I
Y
N
N
GG
P
I
Y
S
P
L
G
P
N
I
W
E
E
P
T
GYIAPP
L
Y
G
A
W
A
T
A
-----
P
Y
F
H
N
G
S
V
P
N
L
W
G
V
L
K
P
S
D
R
P
K
L
W
K
R
P
Y
-
T
A
----
A
G
I
G
G
K
N
A
G
Y
D
Y
S
F
A
S
Y
D
W
Q
K
L
G
W
K
Y
T
A
V
A
C
N
N
S
I
F
-
T
S
P
F
L
P
C
T
H
N
M
A
T
I
D
I
L
Y
S
M
W
D
-
57
Fugue
46.92
16%
-6
- C1 -
4XB6
3
?
D:
[2-278]
-------------------------------------
A
N
L
S
G
Y
N
F
A
Y
L
D
----
E
Q
T
K
R
M
I
R
R
A
I
L
K
A
V
A
I
P
-------------
G
Y
-
Q
V
P
F
G
G
R
E
M
P
M
P
Y
G
W
---
G
T
G
G
I
Q
L
T
A
S
V
I
G
E
S
D
V
L
K
V
I
D
Q
G
A
----
D
D
T
T
N
A
V
S
I
R
N
F
F
K
-
R
V
T
G
V
N
T
T
E
R
T
D
D
A
T
V
I
Q
--
T
R
H
R
I
P
E
T
P
L
T
E
D
Q
I
I
I
F
Q
V
--------
P
I
---------
P
E
PLR
F
I
-
E
P
R
E
T
E
T
R
T
M
H
A
L
E
E
Y
G
V
M
Q
--
V
K
L
Y
E
D
I
A
R
FGHIATTYAY
P
V
K
V
N
G
R
Y
V
M
D
P
S
P
I
P
K
F
D
--
N
P
K
M
D
M
M
P
A
L
Q
L
F
G
A
G
R
E
K
R
------------
I
Y
----------
A
V
P
P
F
T
R
V
E
S
L
D
--
F
D
D
H
P
F
T
V
Q
Q
W
D
E
--
P
C
-
A
I
-----
C
------
G
-------
S
-
T
H
S
Y
L
D
E
V
V
L
--
D
----
D
------
A
G
-
N
-
R
M
F
-
V
C
S
D
T
D
Y
C
R
Q
--
Q
S
E
--
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
41.49
32%
-14
- C3 -
3OO2
1
ALR1_STAAC
B:
[17-96]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
L
N
A
V
A
S
N
----
F
K
--
V
F
-
S
T
-----
L
------
H
-------
P
-
N
K
T
----------
V
M
A
V
V
------
K
A
-
N
-
A
Y
G
-
L
G
S
V
K
--------------------------
V
A
R
H
L
M
E
N
G
A
T
F
F
A
V
A
--------------
T
L
D
E
A
I
E
L
R
M
H
G
I
---------------
T
A
K
I
L
V
L
G
------
V
L
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
E
A
I
K
N
I
S
K
K
L
W
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
D
T
K
T
Y
Q
E
V
-
I
E
I
I
Q
Q
Y
E
Q
L
V
F
E
G
V
F
-
T
H
F
A
C
A
D
E
P
G
D
M
T
T
E
Q
Y
---
Q
R
F
K
D
M
V
N
E
A
I
K
P
E
Y
------
I
H
C
Q
N
S
A
G
-----
S
L
L
M
D
C
Q
F
C
N
A
I
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
Q
-
Q
K
----
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
Q
A
D
P
T
T
I
A
L
L
P
I
G
Y
A
-
D
G
Y
L
R
I
M
Q
G
S
F
V
N
V
N
G
H
Q
C
E
V
I
-
20
PsiBlast_PDB
41.28
29%
5
- C4 -
4AAL
7
?
A:
[247-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
R
Y
K
---
V
T
S
T
A
A
D
K
Y
V
F
R
S
P
S
------
L
R
N
V
A
I
T
M
-----
P
Y
F
H
S
G
K
V
W
K
L
K
D
A
V
K
I
M
G
S
A
Q
L
G
I
S
I
T
-
D
A
-----
D
A
D
K
I
V
T
F
L
N
T
L
T
G
A
Q
P
K
V
M
H
P
V
L
P
P
N
S
D
D
T
P
R
P
V
-
S
N
---------------------
3
PsiBlast_PDB
40.97
32%
-14
- C3 -
3OO2
1
ALR1_STAAC
A:
[17-96]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
L
N
A
V
A
S
N
----
F
K
--
V
F
-
S
T
-----
L
------
H
-------
P
-
N
K
T
----------
V
M
A
V
V
------
K
A
-
N
-
A
Y
G
-
L
G
S
V
K
--------------------------
V
A
R
H
L
M
E
N
G
A
T
F
F
A
V
A
--------------
T
L
D
E
A
I
E
L
R
M
H
G
I
---------------
T
A
K
I
L
V
L
G
------
V
L
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
E
A
I
K
N
I
S
G
E
Q
E
K
K
L
W
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
D
T
K
T
-
Y
Q
E
V
I
E
I
I
Q
Q
Y
E
Q
L
V
F
-
E
G
V
F
T
H
F
A
C
A
D
E
P
G
D
M
T
---
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
A
I
------
K
P
E
Y
I
H
C
Q
-----
N
S
A
G
S
L
L
M
D
C
Q
F
C
N
A
I
R
P
G
I
S
L
Y
G
Y
Y
P
S
-
E
Y
----
V
Q
Q
K
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
Q
A
G
E
S
V
S
Y
G
Y
T
-
A
T
D
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
-
2
PsiBlast_PDB
40.76
32%
-21
- C3 -
4A3Q
4
ALR1_STAAM
A:
[14-93]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
L
N
A
V
A
S
N
----
F
K
--
V
F
-
S
T
-----
L
------
H
-------
P
-
N
K
T
----------
V
M
A
V
V
------
K
A
-
N
-
A
Y
G
-
L
G
S
V
K
--------------------------
V
A
R
H
L
M
E
N
G
A
T
F
F
A
V
A
--------------
T
L
D
E
A
I
E
L
R
M
H
G
I
---------------
T
A
K
I
L
V
L
G
------
V
L
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
E
A
I
K
N
I
S
G
E
Q
E
K
K
L
W
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
D
T
N
T
-
Y
Q
E
V
I
E
I
I
Q
Q
Y
E
Q
L
V
F
-
E
G
V
F
T
H
F
D
M
T
T
E
Q
Y
Q
R
F
---
K
D
M
V
N
E
A
I
K
P
E
Y
I
H
C
------
Q
N
S
A
G
S
L
L
-----
M
D
C
Q
F
C
N
A
I
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
Q
Q
K
V
-
K
V
----
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
S
F
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
-
7
PsiBlast_PDB
40.41
29%
21
- C4 -
3O5C
3
?
A:
[190-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
V
S
C
H
N
G
-
P
A
V
G
G
T
M
F
M
K
M
G
L
I
K
P
F
H
T
N
N
P
A
E
G
R
K
G
V
T
G
---------
K
D
A
D
K
F
V
F
K
V
P
T
------
L
R
N
I
E
L
T
Y
-----
P
Y
F
H
D
G
S
V
W
T
L
E
E
A
V
N
T
M
A
D
I
Q
L
G
Q
K
L
T
-
E
K
----
E
T
K
E
M
V
A
F
L
N
S
L
T
G
E
Q
P
Q
I
S
L
P
I
L
P
P
S
N
K
E
T
P
R
P
V
P
-
F
A
T
G
-------------------
19
PsiBlast_PDB
40.02
36%
49
- C4 -
2C1V
3
?
A:
[250-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
T
T
D
D
E
Y
V
F
R
A
A
P
------
L
R
N
V
A
L
T
A
-----
P
Y
F
H
S
G
V
V
W
E
L
A
E
A
V
K
I
M
S
S
A
Q
I
G
T
E
L
T
-
D
Q
----
Q
A
E
D
I
T
A
F
L
G
T
L
T
G
E
Q
P
V
I
D
H
P
I
L
P
V
R
T
G
T
T
P
L
P
T
P
-
M
----------------------
21
PsiBlast_CBE
39.98
32%
-17
- C3 -
4A3Q
4
ALR1_STAAM
B:
[14-93]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
L
N
A
V
A
S
N
----
F
K
--
V
F
-
S
T
-----
L
------
H
-------
P
-
N
K
T
----------
V
M
A
V
V
------
K
A
-
N
-
A
Y
G
-
L
G
S
V
K
--------------------------
V
A
R
H
L
M
E
N
G
A
T
F
F
A
V
A
--------------
T
L
D
E
A
I
E
L
R
M
H
G
I
---------------
T
A
K
I
L
V
L
G
------
V
L
P
A
K
D
I
D
K
A
I
Q
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
E
A
I
K
N
I
S
G
E
Q
E
K
K
L
W
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
D
T
N
T
-
Y
Q
E
V
I
E
I
I
Q
Q
Y
E
Q
L
V
F
-
E
G
V
F
T
H
F
T
T
E
Q
Y
Q
R
F
K
D
---
M
V
N
E
A
I
K
P
E
Y
I
H
C
Q
N
------
S
A
G
S
L
L
M
D
-----
C
Q
F
C
N
A
I
R
P
G
I
S
L
Y
G
Y
Y
P
S
E
Y
V
Q
Q
K
V
K
V
-
H
L
----
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
S
F
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
-
18
PsiBlast_PDB
38.37
36%
48
- C4 -
2C1U
3
?
A:
[250-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
T
T
D
D
E
Y
V
F
R
A
A
P
------
L
R
N
V
A
L
T
A
-----
P
Y
F
H
S
G
V
V
W
E
L
A
E
A
V
K
I
M
S
S
A
Q
I
G
T
E
L
T
-
D
Q
----
Q
A
E
D
I
T
A
F
L
G
T
L
T
G
E
Q
P
V
I
D
H
P
I
L
P
V
R
T
G
T
T
P
L
P
T
P
-
M
----------------------