@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3384: (2016-02-16 )
MSAVIRVDSLNKTFARKQALFNLRLEIQAGEMVALIGASGSGKSTLLRHVAGLARCDRDNGGSIDVLGRRLQASGRLSGEVRRLRADIGYIFQQFNLVNRLSVLDNVLLGFLGRMPRWRGSLGLFSAEQKRQALEALARVGLADFAGQRASTLSGGQQQRVAIARALTQKAEVILADEPIASLDPESARKVMDILADINRHDGKTVVVTLHQVDYALRYCPRAVALKGGRILFDGSSEYLSEGFLNELYGAEGDTPLLFSDRARRGAESQPELTLARA
Atome Classification :
(41 SA)
.........10....----.-----.----.----.20........30........40........50........60........70.----.....--------.----.80......-..90..----......100.......110........120.......130.......140..-..-...150.......160.......170.......180.......190.......200.......210.......220.......230--------.-...-...240------.........250.......260.......270......-----------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
A
V
I
R
VDSL
N
K
T
F
A
----
R
-----
K
----
Q
----
A
L
F
N
L
R
L
E
I
QAG
E
M
V
A
L
I
GASGS
G
K
S
T
L
L
R
H
V
A
G
L
A
RCDRDNGG
S
I
D
V
L
G
R
R
L
Q
----ASGRL--------
S
----
G
E
V
R
R
L
R
A
D
-
I
G
Y
I
F
Q
----
Q
F
N
L
V
N
R
L
S
V
L
D
N
V
L
L
G
F
-LGRMPRWRGSLGLF
S
A
E
Q
K
R
Q
A
L
E
A
L
A
RVG
L
A
D
-FA-GQRASTLSGG
Q
Q
Q
R
V
A
I
A
R
A
L
T
QKA
E
V
I
L
ADEPIASL
D
P
E
S
A
R
K
V
M
D
I
L
A
D
I
NRHDG
K
T
V
V
V
T
L
HQV
D
Y
A
L
R
YC
P
R
A
VALKG
G
R
I
L
--------F-DG
S
-
S
E
Y
L
--------
S
E
G
F
L
N
E
L
YGAEGDT
P
L
L
F
S
D
R
ARRGAESQP
E
L
TLARA-----------------------------------------------------------------
58
Fugue
91.82
35%
-110
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
QGTR
T
-----
I
----
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
---
G
S
V
L
V
D
G
Q
E
L
T
----
T
L
S
----------
E
----
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
----
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
-
E
L
D
--------
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
EQDTVSEV
F
-
S
H
P
-
K
T
P
L
--------
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
GQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV
29
PsiBlast_CBE
84.69
37%
-112
- C1 -
3TUI
1
METN_ECOLI
H:
[24-254]
---
M
I
K
L
S
N
I
T
K
V
F
H
----
Q
-----
G
TRTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
----
T
L
S
E
--------------
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
----
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
---------
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
-
S
E
V
F
--------
S
H
-----------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.62
37%
-114
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-254]
---
M
I
K
L
S
N
I
T
K
V
F
H
----
Q
-----
G
TRTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
----
T
L
S
E
--------------
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
----
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
---------
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
-
S
E
V
F
--------
S
H
-----------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
84.48
35%
-124
- C1 -
2OLJ
4
?
A:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
F
D
RPQH
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
73
HHSearch
84.16
38%
-112
- C1 -
3TUI
1
METN_ECOLI
C:
[23-252]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
----
Q
GTRT-
I
----
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
---
E
G
S
V
L
V
D
G
Q
E
L
T
----
T
L
S
----------
E
----
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
----
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
-
E
L
D
--------
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
-
Q
D
T
-
V
S
E
V
--------
F
------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
84.11
35%
-121
- C1 -
2OUK
1
?
A:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
F
D
RPQHE
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
31
PsiBlast_CBE
83.84
37%
-110
- C1 -
3TUI
1
METN_ECOLI
D:
[24-254]
---
M
I
K
L
S
N
I
T
K
V
F
H
----
Q
-----
G
TRTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
----
T
L
S
E
--------------
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
----
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
---------
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
-
S
E
V
F
--------
S
H
-----------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.59
37%
-109
- C1 -
3TUI
1
METN_ECOLI
C:
[24-254]
---
M
I
K
L
S
N
I
T
K
V
F
H
----
Q
-----
G
TRTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
----
T
L
S
E
--------------
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
----
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
---------
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
-
S
E
V
F
--------
S
H
-----------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
83.40
35%
-117
- C1 -
2OLK
1
?
D:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
FDRPQHER
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
32
PsiBlast_CBE
83.40
35%
-121
- C1 -
3C4J
4
?
B:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
FDRPQHER
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
39
PsiBlast_CBE
83.37
35%
-116
- C1 -
2OLK
2
?
B:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
FDRPQHER
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.15
37%
-111
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-254]
---
M
I
K
L
S
N
I
T
K
V
F
H
----
Q
-----
G
TRTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
----
T
L
S
E
--------------
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
----
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
---------
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
-
S
E
V
F
--------
S
H
-----------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
82.91
35%
-118
- C1 -
2OUK
1
?
C:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
FDRPQHER
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
13
PsiBlast_PDB
82.79
35%
-117
- C1 -
2Q0H
4
?
A:
[23-263]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
F
D
RPQH
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
38
PsiBlast_CBE
82.75
35%
-114
- C1 -
2OLK
1
?
C:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
FDRPQHER
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
26
PsiBlast_CBE
82.69
37%
-112
- C1 -
3TUZ
1
METN_ECOLI
H:
[24-254]
---
M
I
K
L
S
N
I
T
K
V
F
H
----
Q
-----
G
TRTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
----
T
L
S
E
--------------
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
----
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
---------
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
-
S
E
V
F
--------
S
H
-----------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.48
35%
-114
- C1 -
2OLK
1
?
A:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
F
DRPQH
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.13
39%
-108
- C1 -
4U02
1
?
A:
[1-225]
M
E
P
I
I
R
I
R
N
L
H
K
W
F
G
----
P
-----
L
----
H
----
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
---
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
----
D
D
R
A
L
----------------
R
E
I
R
R
E
-
V
G
M
V
F
Q
----
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
-
M
-
R
V
R
R
W
P
R
E
----
K
A
E
K
K
--
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
-
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
-
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
--------
E
-
E
G
R
-
P
E
E
I
---------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
81.66
37%
-122
- C1 -
3TIF
7
Y796_METJA
B:
[1-223]
---
M
V
K
L
K
N
V
T
K
T
Y
K
----
M
-----
G
----
E
EIIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
---
D
K
P
T
E
G
E
V
Y
I
--
D
N
I
K
----
T
N
D
L
D
--------
D
----
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
----
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
-
I
F
K
---
Y
R
G
A
M
S
--
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
----------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
81.54
37%
-107
- C1 -
3TUI
1
METN_ECOLI
G:
[24-254]
---
M
I
K
L
S
N
I
T
K
V
F
H
----
Q
-----
G
TRTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
---
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
----
T
L
S
E
--------------
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
----
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
---------
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
--------
E
Q
D
T
V
-
S
E
V
F
--------
S
H
-----------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
81.35
35%
-114
- C1 -
3C4J
3
?
A:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
F
D
RPQH
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
24
PsiBlast_CBE
81.25
38%
-119
- C1 -
1L2T
4
Y796_METJA
B:
[1-223]
---
M
I
K
L
K
N
V
T
K
T
Y
K
----
M
-----
G
----
E
EIIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
---
D
K
P
T
E
G
E
V
Y
I
--
D
N
I
K
----
T
N
D
L
D
--------
D
----
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
----
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
-
I
F
K
---
Y
R
G
A
M
S
--
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
----------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
81.12
35%
-115
- C1 -
3C41
3
?
J:
[3-242]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
FDRPQHER
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
41
PsiBlast_CBE
80.95
35%
-116
- C1 -
3C41
3
?
K:
[3-242]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
FDRPQHER
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.75
39%
-111
- C1 -
4U00
3
?
A:
[3-225]
--
P
I
I
R
I
R
N
L
H
K
W
F
G
----
P
-----
L
----
H
----
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
---
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
----
D
D
R
A
L
----------------
R
E
I
R
R
E
-
V
G
M
V
F
Q
----
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
-
M
-
R
V
R
R
W
P
R
E
----
K
A
E
K
K
--
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
-
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
-
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
--------
E
-
E
G
R
-
P
E
E
I
---------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
80.60
35%
-112
- C1 -
2OLJ
3
?
B:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
FDRPQHER
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
5
PsiBlast_PDB
80.21
38%
-109
- C1 -
1F3O
2
Y796_METJA
A:
[2-223]
----
I
K
L
K
N
V
T
K
T
Y
K
----
M
-----
G
----
E
EIIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
---
D
K
P
T
E
G
E
V
Y
I
--
D
N
I
K
----
T
N
D
L
D
--------
D
----
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
----
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
-
I
F
K
---
Y
R
G
A
M
S
--
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.38
37%
-112
- C1 -
3TIF
7
Y796_METJA
A:
[1-223]
---
M
V
K
L
K
N
V
T
K
T
Y
K
----
M
-----
G
----
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
---
D
K
P
T
E
G
E
V
Y
I
--
D
N
I
K
----
T
N
D
L
D
--------
D
----
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
----
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
-
I
F
K
---
Y
R
G
A
M
S
--
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
----------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.93
38%
-115
- C1 -
1L2T
4
Y796_METJA
A:
[1-223]
---
M
I
K
L
K
N
V
T
K
T
Y
K
----
M
-----
G
----
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
---
D
K
P
T
E
G
E
V
Y
I
--
D
N
I
K
----
T
N
D
L
D
--------
D
----
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
----
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
-
I
F
K
---
Y
R
G
A
M
S
--
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
----------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
78.78
34%
-121
- C1 -
4YMU
2
?
A:
[1-223]
---
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
-----
L
----
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
---
G
E
V
F
I
D
G
V
K
I
N
-----
N
G
K
V
--------
N
------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
----
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
------
P
V
K
V
K
K
M
N
K
K
E
A
E
E
--
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
--------
E
-
E
G
T
-
P
E
E
I
---------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
78.77
35%
-115
- C1 -
2Q0H
4
?
B:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
---
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
-
K
V
R
K
W
P
R
E
----
K
A
E
A
K
--
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
F
DRPQH
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
87
HHSearch
77.94
36%
-113
- C1 -
1B0U
4
HISP_SALTY
A:
[5-242]
--
N
K
L
H
V
I
D
L
H
K
R
Y
G
----
G
-----
H
----
E
----
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
---
E
G
A
I
I
V
N
G
Q
N
I
N
----
L
V
R
D
K
DGQLKVAD
K
----
N
Q
L
R
L
L
R
T
R
-
L
T
M
V
F
Q
----
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
-
I
Q
V
L
-------
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
-
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
--------
E
-
E
G
D
-
P
E
Q
V
--------
F
G
-----------------------------------------------------------------------------------------------------
82
HHSearch
77.76
37%
-117
* C1 *
2OLJ
4
?
A:
[22-248]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
-----
L
----
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
----
A
K
-----------
D
----
T
N
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R
-------
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
--------
E
-
E
G
K
-
P
E
D
L
--------
F
D
-----------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
77.16
34%
-120
- C1 -
4YMV
1
?
A:
[1-223]
---
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
-----
L
----
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
---
G
E
V
F
I
D
G
V
K
I
N
-----
N
G
K
V
--------
N
------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
----
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
------
P
V
K
V
K
K
M
N
K
K
E
A
E
E
--
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
--------
E
-
E
G
T
-
P
E
E
I
---------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
76.58
34%
-121
- C1 -
4YMU
2
?
J:
[1-223]
---
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
-----
L
----
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
---
G
E
V
F
I
D
G
V
K
I
N
-----
N
G
K
V
--------
N
------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
----
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
------
P
V
K
V
K
K
M
N
K
K
E
A
E
E
--
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
--------
E
-
E
G
T
-
P
E
E
I
---------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
76.42
34%
-119
- C1 -
4YMV
1
?
J:
[1-223]
---
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
-----
L
----
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
---
G
E
V
F
I
D
G
V
K
I
N
-----
N
G
K
V
--------
N
------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
----
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
------
P
V
K
V
K
K
M
N
K
K
E
A
E
E
--
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
--------
E
-
E
G
T
-
P
E
E
I
---------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
74.93
31%
-121
- C1 -
4HLU
2
ECFA2_THEMA
A:
[5-230]
----
I
E
V
V
N
V
S
H
I
F
H
----
R
GTPLE
K
----
K
----
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
---
T
S
G
D
V
L
Y
D
G
E
R
K
K
----
G
Y
-----------------
E
I
R
R
---
N
-
I
G
I
A
F
Q
YPED
Q
F
-
F
A
E
R
--
V
F
D
E
V
A
F
A
V
-
K
N
F
Y
P
D
-
R
D
P
V
P
L
V
-----
K
K
A
M
E
F
V
G
-
L
D
F
D
S
-
F
K
-
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
--------
F
-
D
G
T
R
M
E
F
L
--------
E
K
-----------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
74.12
31%
-121
- C1 -
4HLU
3
ECFA2_THEMA
B:
[5-230]
----
I
E
V
V
N
V
S
H
I
F
H
----
R
GTPLE
K
----
K
----
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
---
T
S
G
D
V
L
Y
D
G
E
R
K
K
----
G
Y
-----------------
E
I
R
R
---
N
-
I
G
I
A
F
Q
YPED
Q
F
-
F
A
E
R
--
V
F
D
E
V
A
F
A
V
-
K
N
F
Y
P
D
-
R
D
P
V
P
L
V
-----
K
K
A
M
E
F
V
G
-
L
D
F
D
S
-
F
K
-
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
--------
F
-
D
G
T
R
M
E
F
L
--------
E
K
-----------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
71.37
34%
-107
- C1 -
1B0U
4
HISP_SALTY
A:
[7-238]
----
L
H
V
I
D
L
H
K
R
Y
G
----
G
-----
H
----
E
----
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
---
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
K
D
G
Q
L
--------
K
VAD
K
N
Q
L
R
L
L
R
T
R
-
L
T
M
V
F
Q
----
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
-
I
Q
-------
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
-
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
--------
E
-
E
G
D
-
P
E
-----------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
67.40
31%
-116
- C1 -
4ZIR
5
ECFA2_THEMA
A:
[4-229]
----
I
E
V
V
N
V
S
H
I
F
H
----
R
GTPLE
K
----
K
----
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
---
T
S
G
D
V
L
Y
D
G
E
--
K
----
G
Y
-----------------
E
I
R
R
---
N
-
I
G
I
A
F
Q
YPED
Q
F
-
F
A
E
R
--
V
F
D
E
V
A
F
A
V
-
K
N
F
Y
P
D
-
R
D
P
V
P
L
V
-----
K
K
A
M
E
F
V
G
-
L
D
F
D
S
-
F
K
-
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
--------
F
-
D
G
T
R
M
E
F
L
--------
E
K
-----------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
66.68
32%
-112
- C1 -
2PCL
12
LOLD_AQUAE
A:
[2-218]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
----
G
-----
Y
----
E
----
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
-
Y
I
L
G
L
--
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
----
Y
T
N
E
K
--------
E
----
L
S
L
L
R
N
R
-
K
-
L
G
F
V
F
Q
----
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
P
M
-
L
--------
K
M
G
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
-
K
L
-
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
G
T
S
I
V
M
V
T
H
E
R
E
L
A
-
E
L
T
H
R
T
L
E
M
K
D
G
K
V
V
---------------------------------------------------------------------------------------------------------------------------------