@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3636: (2016-02-19 )
MAQKIVRVGDIQIGNDLPFVLFGGMNVLESRDLAMQVCEEYVRVTEKLGIPYVFKASFDKANRSSIHSFRGPGLEEGMKIFEEIKKTFKVPVITDVHEPFQAQPVAEVCDIIQLPAFLSRQTDLVVAMARTNAVINIKKAQFLAPQEMKHILTKCEEAGNDRLILCERGSSFGYNNLVVDMLGFGIMKQFEYPVFFDVTHALQMPGGRADSAGGRRAQVTDLAKAGLSQKLAGLFLEAHPDPEHAKCDGPCALRLNKLEAFLSQLKQLDELIKSFPAIETA
Atome Classification :
(43 SA)
.........10........20........30........40.......-.-50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......-190.--........200.......210.......220.......230........240.......250.......260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
Q
K
I
V
R
V
G
D
I
Q
IGNDL
P
F
V
L
FGG
M
N
V
LES
R
D
L
A
M
Q
V
C
E
E
Y
V
R
V
T
E
KL-G-I
P
Y
V
F
KASFDKANRSSIHSFRGP
G
L
E
E
G
M
K
I
F
E
E
I
K
K
T
FKV
P
V
I
TDVHEPFQAQ
P
V
A
E
V
C
D
I
I
Q
L
P
A
F
L
SRQT
D
L
V
V
A
M
ART
N
A
V
I
N
I
K
K
A
QFL
A
P
Q
E
M
K
H
I
L
T
K
C
E
EAGN
D
R
L
I
L
C
ERGSSFGY
N
N
L
V
V
D
M
L
G
F
G
I
M
K
Q-F--E--Y
P
V
F
F
D
V
T
H
A
LQMPGGRADSAGGR
R
A
Q
V
T
D
L
A
K
A
G
L
S
Q
K
-
L
A
G
L
F
LEAHPDPEHAKCDG
P
C
A
L
R
L
N
K
L
E
A
F
L
S
Q
L
K
Q
L
D
E
L
I
K
SFPAIETA-
1
PsiBlast_PDB
93.60
100%
-136
- C3 -
4LU0
-
KDSA_PSEAE
A:
[10-282]
---
K
I
V
R
V
G
D
I
Q
I
G
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
Q
V
C
E
E
Y
V
R
V
T
E
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
P
G
L
E
E
G
M
K
I
F
E
E
I
K
K
T
F
K
V
P
V
I
T
D
V
H
E
P
F
Q
A
Q
P
V
A
E
V
C
D
I
I
Q
L
P
A
F
L
S
R
Q
T
D
L
V
V
A
M
A
R
T
N
A
V
I
N
I
K
K
A
Q
F
L
A
P
Q
E
M
K
H
I
L
T
K
C
E
E
A
G
N
D
R
L
I
L
C
E
R
G
S
S
F
G
Y
N
N
L
V
V
D
M
L
G
F
G
I
M
K
Q
-
F
--
E
--
Y
P
V
F
F
D
V
T
H
A
L
------------
R
R
A
Q
V
T
D
L
A
K
A
G
L
S
Q
K
-
L
A
G
L
F
L
E
A
H
P
--------------
L
N
K
L
E
A
F
L
S
Q
L
K
Q
L
D
E
L
I
K
S
F
P
------
121
Fugue
89.14
70%
-125
- C3 -
1D9E
2
KDSA_ECOLI
A:
[1-284]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
S
G
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
------------
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
G
-
L
A
G
L
F
I
E
A
H
P
D
P
------
E
P
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
K
52
PsiBlast_CBE
88.61
66%
-133
- C3 -
3FYO
3
KDSA_NEIMB
D:
[3-277]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
C
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
F
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
CG
N
--
L
P
V
I
F
D
V
T
H
S
L
Q
T
----------
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
H
P
------
C
E
G
A
S
A
L
P
L
H
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
22
PsiBlast_CBE
88.51
68%
-129
- C3 -
1D9E
3
KDSA_ECOLI
C:
[1-283]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
SG
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
------------
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
G
-
L
A
G
L
F
I
E
A
H
P
D
P
E
------
P
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
-
2
PsiBlast_PDB
88.39
68%
-125
- C3 -
1D9E
2
KDSA_ECOLI
A:
[1-283]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
S
G
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
------------
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
G
-
L
A
G
L
F
I
E
A
H
P
D
P
E
------
P
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
-
58
PsiBlast_CBE
88.38
67%
-133
- C3 -
3STC
2
KDSA_NEIMB
D:
[3-266]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
F
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
CG
N
--
L
P
V
I
F
D
V
T
H
S
L
-----------
G
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
H
P
---------
P
S
A
L
P
L
H
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
21
PsiBlast_CBE
87.72
68%
-131
- C3 -
1D9E
2
KDSA_ECOLI
D:
[1-283]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
SG
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
------------
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
G
-
L
A
G
L
F
I
E
A
H
P
D
P
--------
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
-
42
PsiBlast_CBE
87.50
67%
-128
- C3 -
4JTL
1
KDSA_NEIMB
D:
[3-277]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
G
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
CG
N
--
L
P
V
I
F
D
V
T
H
S
L
Q
T
----------
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
-------------
A
L
P
L
H
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
3
PsiBlast_PDB
87.48
68%
-118
- C3 -
1GG0
2
KDSA_ECOLI
A:
[1-283]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
S
G
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
C
R
---------
R
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
G
-
L
A
G
L
F
I
E
A
H
P
D
P
E
H
A
K
C
D
G
P
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
-
70
PsiBlast_CBE
87.35
66%
-122
- C3 -
3STG
4
KDSA_NEIMB
B:
[3-265]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
P
-
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
F
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
CG
N
--
L
P
V
I
F
D
V
T
H
S
L
-----------
G
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
H
P
D
P
K
L
A
K
C
D
G
P
S
A
L
P
L
H
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
54
PsiBlast_CBE
87.16
66%
-130
- C3 -
4JTI
1
KDSA_NEIMB
D:
[3-277]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
R
L
A
Q
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
G
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
CG
N
--
L
P
V
I
F
D
V
T
H
S
L
Q
T
R
--------
G
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
H
P
-----------
A
L
P
L
H
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
50
PsiBlast_CBE
86.94
67%
-126
- C3 -
4JTG
1
KDSA_NEIMB
B:
[3-277]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
R
L
A
A
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
F
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
CG
N
--
L
P
V
I
F
D
V
T
H
S
L
Q
T
R
-------
G
G
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
----------------
L
H
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
12
PsiBlast_PDB
86.89
67%
-116
- C3 -
3E9A
1
KDSA_VIBC3
A:
[4-284]
M
E
H
K
I
V
H
V
G
D
I
P
V
A
N
D
K
P
F
T
L
F
A
G
M
N
V
L
E
S
R
D
L
A
M
Q
I
C
E
H
Y
V
K
V
T
D
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
V
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
E
T
F
G
V
K
I
I
T
D
V
H
T
E
A
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
M
S
P
G
Q
V
G
N
I
V
E
K
F
A
E
C
G
N
D
K
V
I
L
C
E
R
G
S
C
H
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
A
--
S
N
G
S
P
I
I
F
D
V
T
H
S
L
Q
-----------
R
R
E
Q
T
V
E
L
A
K
A
G
L
A
T
G
-
I
A
G
L
F
I
E
A
H
P
N
P
D
K
A
R
C
D
G
P
S
A
L
P
L
D
K
L
E
P
F
L
A
Q
M
K
A
L
D
D
L
I
K
S
F
A
H
I
D
---
65
PsiBlast_CBE
86.72
66%
-126
- C3 -
3FYP
2
KDSA_NEIMB
A:
[3-277]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
C
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
F
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
C
G
N
--
L
P
V
I
F
D
V
T
H
S
L
Q
T
-------
S
G
G
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
H
P
--------------
L
H
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
69
PsiBlast_CBE
86.60
66%
-129
- C3 -
3STG
2
KDSA_NEIMB
C:
[3-265]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
P
-
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
F
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
CG
N
--
L
P
V
I
F
D
V
T
H
S
L
-----------
G
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
H
P
D
P
--------
S
A
L
P
L
H
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
60
PsiBlast_CBE
86.51
67%
-126
- C3 -
3STC
2
KDSA_NEIMB
B:
[3-266]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
F
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
CG
N
--
L
P
V
I
F
D
V
T
H
S
L
-----------
G
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
------------
S
A
L
P
L
H
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
51
PsiBlast_CBE
86.51
67%
-131
- C3 -
4JTG
1
KDSA_NEIMB
A:
[3-277]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
R
L
A
A
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
F
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
C
G
N
--
L
P
V
I
F
D
V
T
H
S
L
Q
T
R
--------
G
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
----------------
L
H
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
23
PsiBlast_CBE
86.50
68%
-127
- C3 -
1D9E
3
KDSA_ECOLI
B:
[1-283]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
SG
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
------------
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
G
-
L
A
G
L
F
I
E
A
H
P
D
P
E
------
P
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
-
104
HHSearch
86.47
68%
-130
* C3 *
2QKF
-
KDSA_NEIMB
A:
[2-277]
----
D
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
F
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
T
C
G-
N
--
L
P
V
I
F
D
V
T
H
S
L
Q
----------
G
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
----------------
L
H
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
71
PsiBlast_CBE
86.45
66%
-128
- C3 -
3STG
3
KDSA_NEIMB
A:
[3-265]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
P
-
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
F
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
C
G
N
--
L
P
V
I
F
D
V
T
H
S
L
-----------
G
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
H
P
D
P
--------
S
A
L
P
L
H
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
9
PsiBlast_PDB
86.45
68%
-119
- C3 -
1X6U
1
KDSA_ECOLI
A:
[1-283]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
S
G
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
------------
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
G
-
L
A
G
L
F
I
E
A
H
P
D
P
E
H
A
K
C
D
G
P
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
-
62
PsiBlast_CBE
85.90
66%
-129
- C3 -
3FYP
4
KDSA_NEIMB
D:
[3-277]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
C
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
A
N
R
S
S
I
--
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
F
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
CG
N
--
L
P
V
I
F
D
V
T
H
S
L
Q
T
---------
G
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
H
P
-----------
A
L
P
L
H
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
11
PsiBlast_PDB
85.60
68%
-113
- C3 -
1G7U
1
KDSA_ECOLI
A:
[1-283]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
S
G
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
C
R
D
P
F
V
A
A
S
G
G
R
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
G
-
L
A
G
L
F
I
E
A
H
P
D
P
E
H
A
K
C
D
G
P
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
-
64
PsiBlast_CBE
85.42
66%
-125
- C3 -
3FYP
3
KDSA_NEIMB
B:
[3-277]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
C
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
F
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
C
G
N
--
L
P
V
I
F
D
V
T
H
S
L
Q
---------
G
G
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
H
-----------------
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
67
PsiBlast_CBE
85.12
68%
-123
- C3 -
3STF
2
KDSA_NEIMB
B:
[3-277]
-----
I
K
I
N
D
I
T
L
G
N
N
S
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
S
T
L
Q
T
C
A
H
Y
V
E
V
T
R
K
L
-
G
-
I
P
Y
I
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
E
E
G
L
K
I
F
E
K
V
K
A
E
F
G
I
P
V
I
T
D
V
H
E
P
H
Q
C
Q
P
V
A
E
V
C
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
V
A
M
A
K
T
G
N
V
V
N
I
K
K
P
Q
F
L
S
P
S
Q
M
K
N
I
V
E
K
F
H
E
A
G
N
G
K
L
I
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
G
V
M
K
Q
-
T
CG
N
--
L
P
V
I
F
D
V
T
H
S
L
Q
----------
G
R
R
A
Q
A
L
D
L
A
L
A
G
M
A
T
R
-
L
A
G
L
F
L
E
S
H
-----------------
L
L
E
D
F
L
I
R
I
K
A
L
D
D
L
I
K
S
Q
P
I
L
----
7
PsiBlast_PDB
84.74
68%
-119
- C3 -
1PL9
1
KDSA_ECOLI
A:
[1-283]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
S
G
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
------------
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
G
-
L
A
G
L
F
I
E
A
H
P
D
P
E
H
A
K
C
D
G
P
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
-
6
PsiBlast_PDB
84.67
68%
-115
- C3 -
1PHW
1
KDSA_ECOLI
A:
[1-283]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
S
G
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
------------
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
G
-
L
A
G
L
F
I
E
A
H
P
D
P
E
H
A
K
C
D
G
P
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
-
8
PsiBlast_PDB
83.85
68%
-116
- C3 -
1Q3N
1
KDSA_ECOLI
A:
[1-283]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
SG
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
------------
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
G
-
L
A
G
L
F
I
E
A
H
P
D
P
E
H
A
K
C
D
G
P
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
-
122
Fugue
83.59
69%
-116
- C3 -
1G7V
1
KDSA_ECOLI
A:
[1-284]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
S
G
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
C
R
D
P
F
G
A
A
S
G
G
R
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
-G
L
A
G
L
F
I
E
A
H
P
D
P
E
H
A
K
C
D
G
P
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
K
5
PsiBlast_PDB
83.37
68%
-113
- C3 -
1PHQ
1
KDSA_ECOLI
A:
[1-283]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
S
G
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
------------
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
G
-
L
A
G
L
F
I
E
A
H
P
D
P
E
H
A
K
C
D
G
P
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
-
77
PsiBlast_CBE
83.01
63%
-128
- C3 -
3TMQ
4
?
B:
[13-283]
----------
V
T
A
G
N
S
L
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
F
T
L
D
V
C
G
E
Y
V
A
V
T
R
K
L
-
G
-
I
P
F
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
D
E
G
L
K
I
F
A
E
V
K
A
R
F
G
V
P
V
I
T
D
V
H
E
A
E
Q
A
A
P
V
A
E
I
A
D
V
L
Q
V
P
A
F
L
A
R
Q
T
D
L
V
V
A
I
A
K
A
G
K
P
V
N
V
K
K
P
Q
F
M
S
P
T
Q
L
K
H
V
V
S
K
C
G
E
V
G
N
D
R
V
M
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
R
Q
M
A
E
-
T
--
T
GG
C
P
V
I
F
D
V
T
H
S
L
Q
C
R
D
P
---------
R
Q
V
L
D
L
A
R
A
G
I
A
V
G
-
I
A
G
L
F
L
E
A
H
P
D
P
D
R
A
R
C
---
S
A
L
P
L
H
Q
L
E
G
L
L
S
Q
M
K
A
I
D
D
L
V
K
R
M
P
A
L
E
---
4
PsiBlast_PDB
82.71
68%
-114
- C3 -
1G7V
1
KDSA_ECOLI
A:
[1-283]
M
K
Q
K
V
V
S
I
G
D
I
N
V
A
N
D
L
P
F
V
L
F
G
G
M
N
V
L
E
S
R
D
L
A
M
R
I
C
E
H
Y
V
T
V
T
Q
K
L
-
G
-
I
P
Y
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
P
G
L
E
E
G
M
K
I
F
Q
E
L
K
Q
T
F
G
V
K
I
I
T
D
V
H
E
P
S
Q
A
Q
P
V
A
D
V
V
D
V
I
Q
L
P
A
F
L
A
R
Q
T
D
L
V
E
A
M
A
K
T
G
A
V
I
N
V
K
K
P
Q
F
V
S
P
G
Q
M
G
N
I
V
D
K
F
K
E
G
G
N
E
K
V
I
L
C
D
R
G
A
N
F
G
Y
D
N
L
V
V
D
M
L
G
F
S
I
M
K
K
-
V
S
G
N
--
S
P
V
I
F
D
V
T
H
A
L
Q
C
R
D
P
F
G
A
A
S
G
G
R
R
A
Q
V
A
E
L
A
R
A
G
M
A
V
G
-
L
A
G
L
F
I
E
A
H
P
D
P
E
H
A
K
C
D
G
P
S
A
L
P
L
A
K
L
E
P
F
L
K
Q
M
K
A
I
D
D
L
V
K
G
F
E
E
L
D
T
S
-
78
PsiBlast_CBE
82.65
63%
-107
- C3 -
3TMQ
8
?
A:
[13-283]
----------
V
T
A
G
N
S
L
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
F
T
L
D
V
C
G
E
Y
V
A
V
T
R
K
L
-
G
-
I
P
F
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
D
E
G
L
K
I
F
A
E
V
K
A
R
F
G
V
P
V
I
T
D
V
H
E
A
E
Q
A
A
P
V
A
E
I
A
D
V
L
Q
V
P
A
F
L
A
R
Q
T
D
L
V
V
A
I
A
K
A
G
K
P
V
N
V
K
K
P
Q
F
M
S
P
T
Q
L
K
H
V
V
S
K
C
G
E
V
G
N
D
R
V
M
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
R
Q
M
A
E
-
T
--
T
GG
C
P
V
I
F
D
V
T
H
S
L
Q
C
R
D
P
L
G
D
A
S
G
G
R
R
R
Q
V
L
D
L
A
R
A
G
I
A
V
G
-
I
A
G
L
F
L
E
A
H
P
D
P
D
R
A
R
C
D
G
P
S
A
L
P
L
H
Q
L
E
G
L
L
S
Q
M
K
A
I
D
D
L
V
K
R
M
P
A
L
E
---
76
PsiBlast_CBE
82.57
63%
-105
- C3 -
3TMQ
9
?
C:
[13-283]
----------
V
T
A
G
N
S
L
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
F
T
L
D
V
C
G
E
Y
V
A
V
T
R
K
L
-
G
-
I
P
F
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
D
E
G
L
K
I
F
A
E
V
K
A
R
F
G
V
P
V
I
T
D
V
H
E
A
E
Q
A
A
P
V
A
E
I
A
D
V
L
Q
V
P
A
F
L
A
R
Q
T
D
L
V
V
A
I
A
K
A
G
K
P
V
N
V
K
K
P
Q
F
M
S
P
T
Q
L
K
H
V
V
S
K
C
G
E
V
G
N
D
R
V
M
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
R
Q
M
A
E
-
T
--
T
GG
C
P
V
I
F
D
V
T
H
S
L
Q
C
R
D
P
L
G
D
A
S
G
G
R
R
R
Q
V
L
D
L
A
R
A
G
I
A
V
G
-
I
A
G
L
F
L
E
A
H
P
D
P
D
R
A
R
C
D
G
P
S
A
L
P
L
H
Q
L
E
G
L
L
S
Q
M
K
A
I
D
D
L
V
K
R
M
P
A
L
E
---
73
PsiBlast_CBE
82.21
63%
-108
- C3 -
3UND
6
?
C:
[13-283]
----------
V
T
A
G
N
S
L
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
F
T
L
D
V
C
G
E
Y
V
A
V
T
R
K
L
-
G
-
I
P
F
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
D
E
G
L
K
I
F
A
E
V
K
A
R
F
G
V
P
V
I
T
D
V
H
E
A
E
Q
A
A
P
V
A
E
I
A
D
V
L
Q
V
P
A
F
L
A
R
Q
T
D
L
V
V
A
I
A
K
A
G
K
P
V
N
V
K
K
P
Q
F
M
S
P
T
Q
L
K
H
V
V
S
K
C
G
E
V
G
N
D
R
V
M
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
R
Q
M
A
E
-
T
--
T
GG
C
P
V
I
F
D
V
T
H
S
L
Q
C
R
D
P
L
G
D
A
S
G
G
R
R
R
Q
V
L
D
L
A
R
A
G
I
A
V
G
-
I
A
G
L
F
L
E
A
H
P
D
P
D
R
A
R
C
D
G
P
S
A
L
P
L
H
Q
L
E
G
L
L
S
Q
M
K
A
I
D
D
L
V
K
R
M
P
A
L
E
---
72
PsiBlast_CBE
81.98
63%
-110
- C3 -
3UND
5
?
D:
[13-283]
----------
V
T
A
G
N
S
L
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
F
T
L
D
V
C
G
E
Y
V
A
V
T
R
K
L
-
G
-
I
P
F
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
D
E
G
L
K
I
F
A
E
V
K
A
R
F
G
V
P
V
I
T
D
V
H
E
A
E
Q
A
A
P
V
A
E
I
A
D
V
L
Q
V
P
A
F
L
A
R
Q
T
D
L
V
V
A
I
A
K
A
G
K
P
V
N
V
K
K
P
Q
F
M
S
P
T
Q
L
K
H
V
V
S
K
C
G
E
V
G
N
D
R
V
M
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
R
Q
M
A
E
-
T
--
T
GG
C
P
V
I
F
D
V
T
H
S
L
Q
C
R
D
P
L
G
D
A
S
G
G
R
R
R
Q
V
L
D
L
A
R
A
G
I
A
V
G
-
I
A
G
L
F
L
E
A
H
P
D
P
D
R
A
R
C
D
G
P
S
A
L
P
L
H
Q
L
E
G
L
L
S
Q
M
K
A
I
D
D
L
V
K
R
M
P
A
L
E
---
74
PsiBlast_CBE
81.83
63%
-109
- C3 -
3UND
5
?
B:
[13-283]
----------
V
T
A
G
N
S
L
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
F
T
L
D
V
C
G
E
Y
V
A
V
T
R
K
L
-
G
-
I
P
F
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
D
E
G
L
K
I
F
A
E
V
K
A
R
F
G
V
P
V
I
T
D
V
H
E
A
E
Q
A
A
P
V
A
E
I
A
D
V
L
Q
V
P
A
F
L
A
R
Q
T
D
L
V
V
A
I
A
K
A
G
K
P
V
N
V
K
K
P
Q
F
M
S
P
T
Q
L
K
H
V
V
S
K
C
G
E
V
G
N
D
R
V
M
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
R
Q
M
A
E
-
T
--
T
GG
C
P
V
I
F
D
V
T
H
S
L
Q
C
R
D
P
L
G
D
A
S
G
G
R
R
R
Q
V
L
D
L
A
R
A
G
I
A
V
G
-
I
A
G
L
F
L
E
A
H
P
D
P
D
R
A
R
C
D
G
P
S
A
L
P
L
H
Q
L
E
G
L
L
S
Q
M
K
A
I
D
D
L
V
K
R
M
P
A
L
E
---
75
PsiBlast_CBE
81.45
63%
-108
- C3 -
3UND
6
?
A:
[13-283]
----------
V
T
A
G
N
S
L
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
F
T
L
D
V
C
G
E
Y
V
A
V
T
R
K
L
-
G
-
I
P
F
V
F
K
A
S
F
D
K
A
N
R
S
S
I
H
S
Y
R
G
V
G
L
D
E
G
L
K
I
F
A
E
V
K
A
R
F
G
V
P
V
I
T
D
V
H
E
A
E
Q
A
A
P
V
A
E
I
A
D
V
L
Q
V
P
A
F
L
A
R
Q
T
D
L
V
V
A
I
A
K
A
G
K
P
V
N
V
K
K
P
Q
F
M
S
P
T
Q
L
K
H
V
V
S
K
C
G
E
V
G
N
D
R
V
M
L
C
E
R
G
S
S
F
G
Y
D
N
L
V
V
D
M
L
G
F
R
Q
M
A
E
-
T
--
T
GG
C
P
V
I
F
D
V
T
H
S
L
Q
C
R
D
P
L
G
D
A
S
G
G
R
R
R
Q
V
L
D
L
A
R
A
G
I
A
V
G
-
I
A
G
L
F
L
E
A
H
P
D
P
D
R
A
R
C
D
G
P
S
A
L
P
L
H
Q
L
E
G
L
L
S
Q
M
K
A
I
D
D
L
V
K
R
M
P
A
L
E
---
105
HHSearch
73.95
46%
-106
- C3 -
2NWR
3
KDSA_AQUAE
A:
[2-264]
----------------
E
K
F
L
V
I
A
G
P
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
-
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
-
W
-----
A
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
------
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
-
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
S
D
A
S
T
Q
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
S
K
Y
Y
E
T
I
---
83
PsiBlast_CBE
73.70
47%
-100
- C3 -
2EF9
3
KDSA_AQUAE
B:
[4-260]
------------------
F
L
V
I
A
G
M
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
-
K
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
-
W
--
A
---
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
-
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
S
D
A
P
T
A
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
S
K
Y
-------
97
PsiBlast_CBE
73.27
47%
-105
- C3 -
2NXG
2
KDSA_AQUAE
B:
[3-259]
------------------
F
L
V
I
A
G
P
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
-
K
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
-
W
--
A
---
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
-
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
S
D
A
P
T
A
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
S
K
Y
-------
98
PsiBlast_CBE
72.96
47%
-100
- C3 -
2NXG
3
KDSA_AQUAE
A:
[3-259]
------------------
F
L
V
I
A
G
P
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
-
K
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
-
W
--
A
---
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
-
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
S
D
A
P
T
A
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
S
K
Y
-------
84
PsiBlast_CBE
72.94
47%
-99
- C3 -
2EF9
3
KDSA_AQUAE
A:
[4-260]
------------------
F
L
V
I
A
G
M
N
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
-
K
E
V
E
F
V
F
K
S
S
F
D
K
A
N
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
-
W
--
A
---
K
V
I
Y
D
A
T
H
S
V
Q
L
P
G
G
L
G
D
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
-
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
S
D
A
P
T
A
L
P
L
S
Q
L
E
G
I
I
E
A
I
L
E
I
R
E
V
A
S
K
Y
-------